Min-Seo Choi, Seongsung Kwak, Junhyung Kim, Mi-Sun Park, Soo Min Ko, Taehee Kim, Da Som Jeong, Chang-Hoon Rhee, Gi-Hyeok Yang, Woo-Chan Son, Won-Ho Kang
Purpose: Hyaluronic acid (HA)-based dermal fillers have been approved for various clinical indications, both cosmetic and medical. Previous studies that have assessed the performance of HA dermal fillers have primarily focused on evaluating filler durability, and only a few have studied their distribution within the tissues. The present study aimed to compare tissue integration of various types of HA dermal fillers having different clinical indications and varying injection depths. Methods: To examine the local inflammatory response and distribution pattern of 14 HA dermal fillers (six Neuramis [NEU], one Belotero [BEL], three Juvéderm [JUV], and four Restylane [RES]), each product was injected intradermally and subcutaneously at the backs of two male miniature pigs...
2021: Clinical, Cosmetic and Investigational Dermatology