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https://www.readbyqxmd.com/read/27602971/visual-ultrasonographic-and-microscopic-study-on-hyaluronic-acid-based-gel
#1
Patrick Micheels, Stéphanie Besse, Didier Sarrazin
BACKGROUND: Hyaluronic acid (HA) fillers are commonly used for enhancement of lips, and for softening fine lines and correcting skin depressions. OBJECTIVE: This study sought to investigate whether the Vycross<sup>™</sup> technology used for Volbella<sup>™</sup> gel resulted in a cohesive gel, as documented in our previous studies with three other HA fillers (Restylane<sup>®</sup> NASHA<sup>™</sup> [Q-MED, Uppsala, Sweden], Esthélis<sup>®</sup> Basic CPM™ [Anteis SA, Geneva, Switzerland], and Juvéderm<sup>®</sup> Ultra 3 using Hylacross technology [Allergan, Irvine, CA, USA])...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27602967/patient-reported-outcomes-from-hiv-facial-lipoatrophy-treatment-with-a-volumizing-hyaluronic-acid-filler-a-prospective-open-label-phase-i-and-ii-study
#2
Derek Ho, Jared Jagdeo
BACKGROUND: Human immunodeficiency virus (HIV) facial lipoatrophy (FLA) is associated with the use of highly active antiretroviral therapy (HAART) and HIV disease. HIV FLA is primarily characterized by midface (cheeks and temples) volume loss, resulting in a "sunken" and aged appearance. Filler agents for treatment of HIV FLA can provide midface volumization and improve quality-of-life (QOL). A 20 mg/ml hyaluronic acid (HA) filler (Juvéderm Voluma® XC, Allergan plc, Irvine, CA) may provide an immediate, natural appearing facial enhancement outcome in one treatment...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27363762/hyaluronic-acid-fillers-science-and-clinical-uses
#3
REVIEW
Karol A Gutowski
Hyaluronic acid soft tissue fillers include a range of products (Juvederm Ultra, Juvederm Ultra Plus, Voluma, Restylane Silk, Restylane, Restylane Lyft, and Belotero Balance) that are used commonly for facial rejuvenation and enhancement of facial features. Although these products are similar in many ways, they are not interchangeable and have unique characteristics that need to be considered. Injection sites and techniques for facial rejuvenation are discussed.
July 2016: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27301371/efficacy-and-safety-of-a-hyaluronic-acid-filler-to-correct-aesthetically-detracting-or-deficient-features-of-the-asian-nose-a-prospective-open-label-long-term-study
#4
Steven Liew, Terrence Scamp, Mauricio de Maio, Michael Halstead, Nicole Johnston, Michael Silberberg, John D Rogers
BACKGROUND: There is increasing interest among patients and plastic surgeons for alternatives to rhinoplasty, a common surgical procedure performed in Asia. OBJECTIVES: To evaluate the safety, efficacy, and longevity of a hyaluronic acid filler in the correction of aesthetically detracting or deficient features of the Asian nose. METHODS: Twenty-nine carefully screened Asian patients had their noses corrected with the study filler (Juvéderm VOLUMA [Allergan plc, Dublin, Ireland] with lidocaine injectable gel), reflecting individualized treatment goals and utilizing a standardized injection procedure, and were followed for over 12 months...
July 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27168268/effect-of-different-crosslinking-technologies-on-hyaluronic-acid-behavior-a-visual-and-microscopic-study-of-seven-hyaluronic-acid-gels
#5
Patrick Micheels, Didier Sarazin, Christian Tran, Denis Salomon
BACKGROUND: The mechanical, rheological, and pharmacological properties of hyaluronic acid (HA) gels differ by their proprietary crosslinking technologies.<BR /> OBJECTIVE: To examine the different properties of a range of HA gels using simple and easily reproducible laboratory tests to better understand their suitability for particular indications.<BR /> METHODS AND MATERIALS: Hyaluronic acid gels produced by one of 7 different crosslinking technologies were subjected to tests for cohesivity, resistance to stretch, and microscopic examination...
May 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27128246/a-comprehensive-approach-to-multimodal-facial-aesthetic-treatment-injection-techniques-and-treatment-characteristics-from-the-harmony-study
#6
Vic A Narurkar, Joel L Cohen, Steven Dayan, Michael S Kaminer, Alexander Rivkin, Ava Shamban, Jonathan M Sykes, Craig F Teller, Susan H Weinkle, W Philip Werschler, Adrienne Drinkwater, Michael L Pucci, Conor J Gallagher
BACKGROUND: The HARMONY study is the first clinical trial to assess the impact of a global approach to facial rejuvenation with several minimally invasive modalities, using patient-reported outcome measures. OBJECTIVE: Provide details of this treatment approach and describe investigators' experiences and recommendations based on this study. METHODS: This multicenter, 4-month study evaluated subject satisfaction with and psychological impact of combined treatment with VYC-20L (Juvéderm Voluma XC), HYC-24L (Juvéderm Ultra XC), HYC-24L+ (Juvéderm Ultra Plus XC), onabotulinumtoxinA (Botox), and bimatoprost 0...
May 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/26741384/safety-and-effectiveness-of-hyaluronic-acid-injectable-gel-in-correcting-moderate-nasolabial-folds-in-chinese-subjects
#7
RANDOMIZED CONTROLLED TRIAL
Yan Wu, Jinhua Xu, Yi Jia, Diane K Murphy
BACKGROUND: The hyaluronic acid (HA) dermal filler, Juvéderm® Ultra, which employs Hylacross® technology, produces a gel with a smooth consistency and has demonstrated effectiveness in correcting nasolabial folds (NLFs) in Caucasian populations. OBJECTIVE: To evaluate the safety and effectiveness of Juvéderm Ultra vs Restylane® for the correction of moderate NLFs in Chinese subjects. METHODS: In this double-blind randomized study, adult Chinese subjects with moderate NLFs received Juvéderm Ultra (24 mg/mL) in 1 NLF and Restylane injectable gel (20 mg/mL) in the other NLF...
January 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/26655699/resistant-and-recurrent-late-reaction-to-hyaluronic-acid-based-gel
#8
Ofir Artzi, Christoforos Loizides, Ines Verner, Marina Landau
BACKGROUND: Late reactions to hyaluronic acid (HA)-based fillers have a recorded rate of 0.02%. The recent experience with a newly introduced filler in the tear trough area and the lips showed higher rate of reactions with a tendency to persistency and recurrences. OBJECTIVE: To delineate the features of reactions to this newly introduced filler. MATERIALS AND METHODS: Medical records of 400 patients (360 women and 40 men; average age = 49...
January 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/26618465/the-myth-of-the-biphasic-hyaluronic-acid-filler
#9
J Åke Öhrlund, Katarina L M Edsman
BACKGROUND: The terms "biphasic" and "monophasic" have been used frequently as a means of differentiating hyaluronic acid (HA) fillers. This type of categorization is based on misinterpretations of the term "phase" and provides no help to the practitioner when selecting the most appropriate product for each indication, patient, and injection technique. OBJECTIVE: The purpose of this study was to analyze the properties of 2 HA filler families; Juvederm (JUV) (Allergan), often stated to be monophasic and Restylane (RES) (Galderma), often stated to be biphasic, and discuss what properties may have led to the use of the terms monophasic and biphasic...
December 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/26618456/safety-and-effectiveness-of-the-hyaluronic-acid-filler-hyc-24l-for-lip-and-perioral-augmentation
#10
RANDOMIZED CONTROLLED TRIAL
Steven Dayan, Suzanne Bruce, Suzanne Kilmer, Jeffrey S Dover, Jeanine B Downie, Susan C Taylor, Annette Skorupa, Diane K Murphy
BACKGROUND: Hyaluronic acid gels are increasingly used for augmentation of the lips. OBJECTIVE: To assess the safety and effectiveness of Juvéderm Ultra XC, a 24 mg/mL hyaluronic acid gel containing 0.3% (wt/wt) lidocaine (HYC-24L), for augmentation of the lips. METHODS: This ongoing, multicenter, single-blind study randomized 213 subjects to the treatment group (n = 157) or concurrent no-treatment control group that received delayed treatment (n = 56)...
December 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/26618455/volumizing-hyaluronic-acid-filler-for-midface-volume-deficit-results-after-repeat-treatment
#11
RANDOMIZED CONTROLLED TRIAL
Leslie Baumann, Rhoda S Narins, Kenneth Beer, Arthur Swift, Kimberly J Butterwick, Julius Few, Adrienne Drinkwater, Diane K Murphy
BACKGROUND: Juvéderm Voluma XC (VYC-20L; hyaluronic acid gel) is approved in the United States for correction of age-related midface volume deficit (MVD). OBJECTIVE: Assess safety and effectiveness of VYC-20L after repeat treatment. METHODS: Subjects with MVD underwent optional repeat treatment 12 to 24 months after initial treatment if correction was lost or at 24 months regardless of loss of correction (n = 167). Investigators rated outcomes on the Mid-Face Volume Deficit Scale (MFVDS) and the Global Aesthetic Improvement Scale (GAIS)...
December 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/26606435/hyc-24l-demonstrates-greater-effectiveness-with-less-pain-than-cpm-22-5-for-treatment-of-perioral-lines-in-a-randomized-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
Kimberly Butterwick, Ellen Marmur, Vic Narurkar, Sue Ellen Cox, John H Joseph, Neil S Sadick, Ruth Tedaldi, Sarah Wheeler, Julia K Kolodziejczyk, Conor J Gallagher
OBJECTIVE: This trial compares the effectiveness and safety of HYC-24L (Juvéderm Ultra XC; Allergan plc, Dublin, Ireland) (24 mg/mL of hyaluronic acid, 0.3% lidocaine) and CPM-22.5 (Belotero Balance; Merz Aesthetics, Raleigh, NC) (22.5 mg/mL of hyaluronic acid) for the treatment of perioral lines. MATERIALS AND METHODS: Men and women aged 35 years or older with moderate-to-severe perioral lines were recruited for this randomized controlled, rater-blinded, 2-arm trial...
December 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/26313675/aesthetic-policy-and-procedure-protocols-a-must-have-for-every-aesthetic-medical-provider
#13
Connie Brennan
Treatment guidelines are a crucial part of every medical aesthetic practice and must be in place before utilizing aesthetic medical injectables. An "Aesthetic Policy and Procedure Manual" features specific details (e.g., patient assessment, indication, contraindications, warnings and precautions, injection techniques, documentation, etc.) around dermal fillers (e.g., Restylane, Juvéderm, Voluma), hyaluronidase, neurotoxins (e.g., Botox Cosmetic, Dysport, and Xeomin) and Sculptra. This article describes why an "Aesthetic Policy and Procedure" manual is a necessary tool in every aesthetic provider's armamentarium, what it is composed of, as well as how these guidelines serve as a protective mechanism for the aesthetic provider's clinic if legal action is brought against their staff, their medical director, and/or their clinic...
July 2015: Plastic Surgical Nursing
https://www.readbyqxmd.com/read/26230330/clinical-experience-with-11-460-ml-of-a-20-mg-ml-smooth-highly-cohesive-viscous-hyaluronic-acid-filler
#14
Shannon Humphrey, Jean Carruthers, Alastair Carruthers
BACKGROUND: A 3-dimensional approach to facial rejuvenation restores volume lost over time. Hyaluronic acid (HA) filling agents provide long-lasting correction with minimal side effects and a high level of patient satisfaction. The newest HA formulation is a 20-mg/mL smooth cohesive filler (Juvéderm Voluma [HA-V]) that combines both low- and high-molecular-weight HA for more efficient cross-linking and greater lift capabilities. OBJECTIVE: To document the clinical experience with HA-V over the course of 68 months...
September 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/26218727/duration-of-effect-by-injection-volume-and-facial-subregion-for-a-volumizing-hyaluronic-acid-filler-in-treating-midface-volume-deficit
#15
RANDOMIZED CONTROLLED TRIAL
Dee Anna Glaser, Jeffrey M Kenkel, Deepali Paradkar-Mitragotri, Diane K Murphy, Linda Romagnano, Adrienne Drinkwater
BACKGROUND: Juvéderm Voluma XC (VYC-20L) is approved in the United States for correction of age-related volume loss in the midface region in adults. OBJECTIVE: To characterize the effects of VYC-20L in 3 midface subregions based on injection volumes. METHODS: In this single-blind controlled trial, subjects with midface volume deficit received VYC-20L in ≥1 of 3 facial subregions (zygomaticomalar, anteromedial cheek, and submalar), with touch-up treatment available 30 days later...
August 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/26166260/delayed-onset-nodules-secondary-to-a-smooth-cohesive-20-mg-ml-hyaluronic-acid-filler-cause-and-management
#16
Katie Beleznay, Jean D A Carruthers, Alastair Carruthers, Mark E Mummert, Shannon Humphrey
BACKGROUND: The shift from 2- to 3-dimensional soft tissue augmentation has allowed the development of hyaluronic acid (HA) fillers, which are long lasting and also reversible. Delayed-onset inflammatory nodules have recently been reported with the use of HA fillers. OBJECTIVE: The authors document their experience with delayed-onset nodules after 3-dimensional facial injection of Juvéderm Voluma (HA-V) over 68 months. MATERIALS AND METHODS: The authors conducted a retrospective chart review of patients who were treated with HA-V between February 1, 2009, and September 30, 2014, to evaluate for delayed-onset nodules...
August 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/25964628/a-multicenter-single-blind-randomized-controlled-study-of-a-volumizing-hyaluronic-acid-filler-for-midface-volume-deficit-patient-reported-outcomes-at-2-years
#17
RANDOMIZED CONTROLLED TRIAL
Julius Few, Sue Ellen Cox, Deepali Paradkar-Mitragotri, Diane K Murphy
BACKGROUND: Juvéderm Voluma XC is a volumizing hyaluronic acid filler used for correction of age-related midface volume deficit (MVD). OBJECTIVES: The effectiveness of Juvéderm Voluma XC was examined from the patient perspective. METHODS: Patients with moderate to severe age-related MVD (N = 235) received Juvéderm Voluma XC. At quarterly follow-up visits for 2 years, patients rated treatment outcomes on the Global Aesthetic Improvement Scale (GAIS), overall satisfaction with facial appearance, satisfaction with midfacial regions, achievement of treatment goal, Look and Feel of the Midface (LAFM), and Self-Perception of Age (SPA)...
July 2015: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/25878933/discussion-juv%C3%A3-derm-volbella-with-lidocaine-for-lip-and-perioral-enhancement-a-prospective-randomized-controlled-trial
#18
Alessandra Grassi Salles
No abstract text is available yet for this article.
March 2015: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/25878932/juv%C3%A3-derm-volbella-with-lidocaine-for-lip-and-perioral-enhancement-a-prospective-randomized-controlled-trial
#19
Hervé Raspaldo, Jonquille Chantrey, Lakdhar Belhaouari, Roy Saleh, Diane K Murphy
BACKGROUND: Juvéderm Volbella with Lidocaine is a new hyaluronic acid dermal filler. METHODS: In this prospective, randomized, multicenter study, 280 subjects desiring lip volume enhancement were treated with Juvéderm Volbella with Lidocaine or Restylane-L. Investigators rated treatment outcomes on Allergan's Lip Fullness Scale, Perioral Lines Scale, and Oral Commissures Severity Scale. A blinded independent central reviewer (ICR) assessed 3-dimensional digital photographs using these scales...
March 2015: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/25830247/filler-frontier-what-s-new-and-heading-west-to-the-us-market
#20
REVIEW
Melanie D Palm
The amount of fillers approved by the United States Food and Drug Administration (FDA) for use in facial volume augmentation is diminutive in comparison to filler products employed worldwide. In the near future, several new hyaluronic acid filler products will be available to the United States market. Already approved fillers include Belotero Balance for fine lines, Juvéderm Voluma XC for midfacial volume loss replacement, and Restylane Silk for perioral lines and lip augmentation. Volbella, currently under FDA evaluation, will be used for fine-line correction and lip augmentation...
December 2014: Seminars in Cutaneous Medicine and Surgery
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