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https://www.readbyqxmd.com/read/29742193/nodule-formation-following-treatment-with-hyaluronic-acid-fillers-a-report-of-two-challenging-cases
#1
Meredith L Orseth, Nicole Lee, Omer Ibrahim, Kenneth A Arndt, Michael Kaminer
Nodule formation can be a potentially disfiguring adverse event of soft tissue fillers. Limited treatment consensus exists regarding the optimal approach for addressing recurrent and persistent nodules. Here we describe two challenging cases of nodules that developed following injection with Restylane and Juvéderm Voluma. We review suspected pathophysiology and discuss our treatment approach. J Drugs Dermatol. 2018;17(5):580-581.
May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29701621/safety-and-effectiveness-of-the-hyaluronic-acid-dermal-filler-vyc-17-5l-for-nasolabial-folds-results-of-a-randomized-controlled-study
#2
Gary Monheit, Kenneth Beer, Bhushan Hardas, Pearl E Grimes, Barry M Weichman, Vince Lin, Diane K Murphy
BACKGROUND: Juvéderm Vollure XC (VYC-17.5L) belongs to a family of nonanimal hyaluronic acid (HA) gels based on the Vycross technology platform. OBJECTIVE: To evaluate the safety and effectiveness of VYC-17.5L for correction of moderate to severe nasolabial folds (NLFs) compared with a control HA dermal filler. METHODS: In this double-blind study, 123 adults with 2 moderate or severe NLFs as measured on the 5-point photonumeric NLF severity scale (NLFSS) were randomized to VYC-17...
May 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29621374/novel-use-of-a-volumizing-hyaluronic-acid-filler-for-treatment-of-infraorbital-hollows
#3
Michael B Hall, Sudeep Roy, Edward D Buckingham
Importance: Hyaluronic acid filler can be safely used as a soft-tissue filler for correction of infraorbital hollowing. It has a high overall patient satisfaction profile among patients. Objective: To report safety and patient satisfaction outcomes of Juvéderm Voluma XC for correction of infraorbital hollows. Design, Setting, and Patients: This was a retrospective observational study performed at a private ambulatory facial plastic and reconstructive surgery practice...
April 5, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29506034/safety-and-effectiveness-of-repeat-treatment-with-vyc-15l-for-lip-and-perioral-enhancement-results-from-a-prospective-multicenter-study
#4
Alexander Rivkin, Susan H Weinkle, Bhushan Hardas, Robert A Weiss, Dee Anna Glaser, Brian S Biesman, Andrew Schumacher, Diane K Murphy
Background: VYC-15L (Juvéderm Volbella XC) is a non-animal crosslinked hyaluronic acid (HA) gel with lidocaine. Objective: To evaluate safety and effectiveness of repeat treatment with VYC-15L administered 1 year after treatment for lip and perioral enhancement. Methods: In this prospective multicenter study, 124 subjects with minimal, mild, or moderate lip fullness on the validated 5-point Allergan Lip Fullness Scale (LFS) who received initial/touch-up treatment with VYC-15L received repeat treatment with VYC-15L 1 year after initial treatment...
January 30, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29390116/safety-and-effectiveness-of-repeat-treatment-with-vyc-15l-for-lip-and-perioral-enhancement-results-from-a-prospective-multicenter-study
#5
Alexander Rivkin, Susan H Weinkle, Bhushan Hardas, Robert A Weiss, Dee Anna Glaser, Brian S Biesman, Andrew Schumacher, Diane K Murphy
Background: VYC-15L (Juvéderm Volbella XC) is a non-animal crosslinked hyaluronic acid (HA) gel with lidocaine. Objective: To evaluate safety and effectiveness of repeat treatment with VYC-15L administered 1 year after treatment for lip and perioral enhancement. Methods: In this prospective multicenter study, 124 subjects with minimal, mild, or moderate lip fullness on the validated 5-point Allergan Lip Fullness Scale (LFS) who received initial/touch-up treatment with VYC-15L received repeat treatment with VYC-15L 1 year after initial treatment...
January 30, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29218476/google-trends-as-a-resource-for-informing-plastic-surgery-marketing-decisions
#6
Brittany Ward, Max Ward, Boris Paskhover
BACKGROUND: Celebrities have long influenced the medical decisions of the general population. By analyzing Google search data using Google Trends, we measured the impact of highly publicized plastic surgery-related events on the interest level of the general population in specific search terms. Additionally, we investigated seasonal and geographic trends around interest in rhinoplasties, which is information that physicians and small surgical centers can use to optimize marketing decisions...
April 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28858926/a-prospective-open-label-study-of-hyaluronic-acid-based-filler-with-lidocaine-vyc-15l-treatment-for-the-correction-of-infraorbital-skin-depressions
#7
Francois Niforos, Raj Acquilla, Patricia Ogilvie, Marva Safa, Massimo Signorini, Lela Creutz, Graeme Kerson, Michael Silberberg
BACKGROUND: Infraorbital skin depressions are one of the most troublesome facial areas for aesthetically aware patients. OBJECTIVE: Evaluate effectiveness and safety of Juvéderm Volbella with Lidocaine (VYC-15L; Allergan plc, Dublin, Ireland) for correction of bilateral infraorbital depressions. METHODS: In this 12-month, prospective, uncontrolled, open-label study, subjects aged ≥18 years with infraorbital depressions rated ≥1 on the Allergan Infra-oRbital Scale (AIRS) received injections of VYC-15L with optional touch-up treatment on Day 14...
October 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28595250/prospective-split-face-randomized-long-term-blinded-objective-comparison-of-the-performance-and-tolerability-of-two-new-hyaluronic-acid-fillers
#8
Patrick Trevidic, Pierre Andre, Laurent Benadiba, Jean-Jacques Deutsch, Olivier Galatoire, Philippe Garcia, Anne Grand-Vincent, Sylvie Boisnic, Jean-Charles Kerihuel, Catherine Salomon
BACKGROUND: There are requirements for long-term, objective comparisons of hyaluronic acid (HA) dermal fillers. OBJECTIVE: To compare efficacy and tolerability of ART FILLER Universal (AFU) and ART FILLER Fine lines (AFFL) with the existing HA fillers for the treatment of nasolabial folds and crow's feet. MATERIALS AND METHODS: Prospective, randomized, rater- and patient-blind, split-face comparison of AFU with JUVEDERM Ultra 3 (JUV) and AFFL with FIRST LINES PureSense (FLPS)...
June 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28538556/a-randomized-controlled-multicenter-study-of-juv%C3%A3-derm-voluma-for-enhancement-of-malar-volume-in-chinese-subjects
#9
RANDOMIZED CONTROLLED TRIAL
Dong Li, Xiaojun Wang, Yan Wu, Jiaming Sun, Qin Li, Shuzhong Guo, Yi Jia, Diane K Murphy
BACKGROUND: Hyaluronic acid gels are used to restore volume to the midface, but there are few data published on this use in Asian subjects. METHODS: This study evaluated the safety and effectiveness in Chinese subjects of Juvéderm Voluma, a 20-mg/ml hyaluronic acid gel formulated for midface volumizing. This prospective, multicenter study randomized 119 subjects aged 18 years or older to a treatment group and 27 subjects to a no-treatment control group. The primary effectiveness endpoint was the objectively measured magnitude of change from baseline in volume of the midface area (right and left combined) calculated by digital analysis at month 6 using three-dimensional images for all subjects in both groups...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28510696/autologous-adipose-derived-tissue-matrix-part-ii-implantation-biology
#10
Stephen A Schendel
Background: In part 1 of this study it was shown that liposuctioned fat could be a sufficient source of autologous collagen for use as a filler or in reconstruction. The collagen composition in liposuctioned fat was shown to form a cross-linked helical matrix composed of types II, III, and IV. Additionally, viable adipocytes and fibroblasts among other cells were found. Objectives: The purpose of this research was to study the biology of this matrix after subsequent implantation compared to Juvederm (Allergan, Parsippany, NJ) common soft tissue filler...
October 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28498207/the-kinetics-of-reversible-hyaluronic-acid-filler-injection-treated-with-hyaluronidase
#11
RANDOMIZED CONTROLLED TRIAL
Margit L W Juhász, Melissa K Levin, Ellen S Marmur
BACKGROUND: Hyaluronidase is an enzyme capable of dissolution of hyaluronic acid (HA). There is a lack of evidence-based research defining time- and concentration-dependent reversal of HA filler using hyaluronidase. OBJECTIVE: To explore the efficacy of different concentrations of hyaluronidase in digesting commercially available HA-based reversible fillers-Belotero Balance (BEL), Juvederm Ultra XC (JUVXC), Juvederm Ultra Plus (JUVX+), Juvederm Voluma XC (JUVV), Restylane-L (RESL), Restylane Silk (RESS), and Perlane/Restylane Lyft (RESLYFT)...
June 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28203492/safety-and-effectiveness-of-juv%C3%A3-derm-ultra-plus-injectable-gel-in-correcting-severe-nasolabial-folds-in-chinese-subjects
#12
Dong Li, Yun Xie, Qin Li, Jiaming Sun, Ping Jiang, Yi Jia, Diane K Murphy, Qingfeng Li
BACKGROUND: Hyaluronic acid dermal fillers are effective in correcting severe nasolabial folds (NLFs) in non-Asian populations. We assessed safety and effectiveness of Juvéderm Ultra Plus in a Chinese population. METHODS: This double-blind study randomized Chinese subjects with severe NLFs to Juvéderm Ultra Plus (24 mg/mL) in 1 NLF and Restylane injectable gel (20 mg/mL) in the other NLF. NLFs were evaluated using the validated 5-point photonumeric Allergan NLF Severity Scale (0 is "no wrinkle" and 4 is "very deep wrinkle")...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28157728/safety-and-effectiveness-of-vyc-15l-a-hyaluronic-acid-filler-for-lip-and-perioral-enhancement-one-year-results-from-a-randomized-controlled-study
#13
RANDOMIZED CONTROLLED TRIAL
Roy G Geronemus, David E Bank, Bhushan Hardas, Ava Shamban, Barry M Weichman, Diane K Murphy
BACKGROUND: VYC-15L (Juvéderm Volbella XC) is a nonanimal crosslinked hyaluronic acid (HA) gel with lidocaine. OBJECTIVE: To evaluate the safety and effectiveness of VYC-15L for lip and perioral enhancement versus a nonanimal stabilized HA with lidocaine (Restylane-L; NASHA). METHODS: This prospective multicenter study randomized 225 adults with minimal, mild, or moderate lip fullness on the validated 5-point Allergan Lip Fullness Scale (LFS) to treatment with VYC-15L or NASHA; optional touch-up was administered 30 days later...
March 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28095576/facial-contouring-with-fillers-neuromodulators-and-lipolysis-to-achieve-a-natural-look-in-patients-with-facial-fullness
#14
Chytra Anand
BACKGROUND: The desire for and use of nonsurgical injectable esthetic facial treatments is on a rise in Asia. Recent advances, including more versatile facial fillers, refined injection techniques, and adoption of a global facial approach, have in turn contributed to improved patient outcomes and increased patient satisfaction. The sought after nonsurgical treatments include the use of botulinum toxin, con- touring of the face with soft tissue fillers, and thinning of the face with injection lipolysis...
December 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27602971/visual-ultrasonographic-and-microscopic-study-on-hyaluronic-acid-based-gel
#15
Patrick Micheels, Stéphanie Besse, Didier Sarrazin
BACKGROUND: Hyaluronic acid (HA) fillers are commonly used for enhancement of lips, and for softening fine lines and correcting skin depressions. OBJECTIVE: This study sought to investigate whether the Vycross<sup>™</sup> technology used for Volbella<sup>™</sup> gel resulted in a cohesive gel, as documented in our previous studies with three other HA fillers (Restylane<sup>®</sup> NASHA<sup>™</sup> [Q-MED, Uppsala, Sweden], Esthélis<sup>®</sup> Basic CPM™ [Anteis SA, Geneva, Switzerland], and Juvéderm<sup>®</sup> Ultra 3 using Hylacross technology [Allergan, Irvine, CA, USA])...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27602967/patient-reported-outcomes-from-hiv-facial-lipoatrophy-treatment-with-a-volumizing-hyaluronic-acid-filler-a-prospective-open-label-phase-i-and-ii-study
#16
Derek Ho, Jared Jagdeo
BACKGROUND: Human immunodeficiency virus (HIV) facial lipoatrophy (FLA) is associated with the use of highly active antiretroviral therapy (HAART) and HIV disease. HIV FLA is primarily characterized by midface (cheeks and temples) volume loss, resulting in a "sunken" and aged appearance. Filler agents for treatment of HIV FLA can provide midface volumization and improve quality-of-life (QOL). A 20 mg/ml hyaluronic acid (HA) filler (Juvéderm Voluma® XC, Allergan plc, Irvine, CA) may provide an immediate, natural appearing facial enhancement outcome in one treatment...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27363762/hyaluronic-acid-fillers-science-and-clinical-uses
#17
REVIEW
Karol A Gutowski
Hyaluronic acid soft tissue fillers include a range of products (Juvederm Ultra, Juvederm Ultra Plus, Voluma, Restylane Silk, Restylane, Restylane Lyft, and Belotero Balance) that are used commonly for facial rejuvenation and enhancement of facial features. Although these products are similar in many ways, they are not interchangeable and have unique characteristics that need to be considered. Injection sites and techniques for facial rejuvenation are discussed.
July 2016: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27301371/efficacy-and-safety-of-a-hyaluronic-acid-filler-to-correct-aesthetically-detracting-or-deficient-features-of-the-asian-nose-a-prospective-open-label-long-term-study
#18
Steven Liew, Terrence Scamp, Mauricio de Maio, Michael Halstead, Nicole Johnston, Michael Silberberg, John D Rogers
BACKGROUND: There is increasing interest among patients and plastic surgeons for alternatives to rhinoplasty, a common surgical procedure performed in Asia. OBJECTIVES: To evaluate the safety, efficacy, and longevity of a hyaluronic acid filler in the correction of aesthetically detracting or deficient features of the Asian nose. METHODS: Twenty-nine carefully screened Asian patients had their noses corrected with the study filler (Juvéderm VOLUMA [Allergan plc, Dublin, Ireland] with lidocaine injectable gel), reflecting individualized treatment goals and utilizing a standardized injection procedure, and were followed for over 12 months...
July 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27168268/effect-of-different-crosslinking-technologies-on-hyaluronic-acid-behavior-a-visual-and-microscopic-study-of-seven-hyaluronic-acid-gels
#19
Patrick Micheels, Didier Sarazin, Christian Tran, Denis Salomon
BACKGROUND: The mechanical, rheological, and pharmacological properties of hyaluronic acid (HA) gels differ by their proprietary crosslinking technologies.<BR /> OBJECTIVE: To examine the different properties of a range of HA gels using simple and easily reproducible laboratory tests to better understand their suitability for particular indications.<BR /> METHODS AND MATERIALS: Hyaluronic acid gels produced by one of 7 different crosslinking technologies were subjected to tests for cohesivity, resistance to stretch, and microscopic examination...
May 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27128246/a-comprehensive-approach-to-multimodal-facial-aesthetic-treatment-injection-techniques-and-treatment-characteristics-from-the-harmony-study
#20
MULTICENTER STUDY
Vic A Narurkar, Joel L Cohen, Steven Dayan, Michael S Kaminer, Alexander Rivkin, Ava Shamban, Jonathan M Sykes, Craig F Teller, Susan H Weinkle, W Philip Werschler, Adrienne Drinkwater, Michael L Pucci, Conor J Gallagher
BACKGROUND: The HARMONY study is the first clinical trial to assess the impact of a global approach to facial rejuvenation with several minimally invasive modalities, using patient-reported outcome measures. OBJECTIVE: Provide details of this treatment approach and describe investigators' experiences and recommendations based on this study. METHODS: This multicenter, 4-month study evaluated subject satisfaction with and psychological impact of combined treatment with VYC-20L (Juvéderm Voluma XC), HYC-24L (Juvéderm Ultra XC), HYC-24L+ (Juvéderm Ultra Plus XC), onabotulinumtoxinA (Botox), and bimatoprost 0...
May 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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