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Hyaluronic acid

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https://www.readbyqxmd.com/read/29450988/salso-bromo-iodine-thermal-water-a-nonpharmacological-alternative-treatment-for-postnasal-drip-related-cough-in-children-with-upper-respiratory-tract-infections
#1
I La Mantia, G Ciprandi, A Varricchio, F Cupido, C Andaloro
Postnasal drip (PND)-related cough is a very common symptom in patients with upper respiratory tract infections (URTIs). At present, there is not a standard treatment for postnasal drip and postnasal drip-related cough. The aim of this pilot study was to evaluate the efficacy of a specific salso-bromo-iodine thermal water containing hyaluronic acid and grapefruit seed extract (SBI-H-GSE) comparing it with a normal saline solution in children with URTIs who refer PND-related symptoms. The study was randomized, single-blind, and controlled...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29450666/recent-advances-in-hyaluronic-acid-based-therapy-for-osteoarthritis
#2
REVIEW
Steven Bowman, Mohamed E Awad, Mark W Hamrick, Monte Hunter, Sadanand Fulzele
Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the progression of the disease, but none have been shown to ubiquitously treat and cure the disease. One of the strategies uses the high molecular weight molecule hyaluronic acid as either an injectable or oral supplement for treatment. Hyaluronic acid (HA) is a relatively new treatment that has shown varied results through several clinical trials...
February 16, 2018: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29445786/amplified-polarization-properties-of-electrospun-nanofibers-containing-fluorescent-dyes-and-helical-polymer
#3
N Kaerkitcha, T Sagawa
Nanofibers with the cationic fluorescent molecules, 1-pyrenemethylamine hydrochloride (PyrMA) and α,β,γ,δ-tetrakis(1-methylpyridinium-4-yl)porphyrin p-toluenesulfonate (TMPyP), in the presence of complementary anionic chiral polysaccharide, hyaluronic acid (HA) and transparent polymer, polyethylene oxide (PEO) were successfully prepared using an electrospinning technique. The results showed that the fluorescence spectra of electrospun nanofibers (ENFs) of PEO-HA-PyrMA exhibit a higher amount of pyrene excimer emission when the [PyrMA]/[HA] ratio was increased from 0...
February 15, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29442396/effect-of-hyaluronic-acid-enriched-transfer-medium-on-frozen-thawed-embryo-transfer-outcomes
#4
Wei Fu, Min Yu, Xiao-Jin Zhang
AIM: To determine if hyaluronic acid-enriched transfer medium (HETM) affects the implantation rate (IR) and clinical pregnancy rate (PR) in women undergoing frozen-thawed embryo transfer (FET). METHODS: The records of women who underwent FET from May 2014 to October 2014 were retrospectively reviewed. Outcome measures were IR and PR. RESULTS: In all 1721 cycles of 1632 patients were included in this study. HETM was used for 347 cycles of 342 patients, and standard medium for 1374 cycles of 1290 patients...
February 14, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29442167/real-time-monitoring-of-hyaluronic-acid-fermentation-by-in-situ-transflectance-spectroscopy
#5
Kirubhakaran Puvendran, Kozhiyalam Anupama, Guhan Jayaraman
Hyaluronic acid (HA) is a high-value polysaccharide with many biomedical applications. Microbial production of HA is now replacing the traditional extraction method from rooster combs. Production of medical-grade HA with defined characteristics requires controlled process conditions because there are many fermentation process parameters that affect the microbial synthesis of HA. This necessitates the development of online tools for monitoring multiple analytes during microbial fermentation. Here, we describe the application of in situ transflectance spectroscopy for online quantification of seven major fermentation analytes, viz...
February 13, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29441775/-hydrating-cleansing-efficacy-and-tolerability-of-new-formulations-with-hyaluronic-acid-0-2-for-intimate-hygiene-in-the-woman-in-fertile-age-and-menopause
#6
Francesca Albani, Adriana Bonfigli, Francesca Consolaro, Luigi Rigano, Monica Campisi
Dehydration of genital areas, known as vaginal dryness, frequently affects woman's life, from fertile to postmenopausal period, and must be treated with specific products, including proper intimate cleansing. Based on that, two new cleanser formulations, characterized by Hyaluronic Acid 0.2% as main ingredient, have been developed (Hyalo Gyn® Intimo Active and Hyalo Gyn® Intimo Advance), with the aim to provide an effective hydration of the vaginal, vulvar, perianal and anal areas beyond guaranteeing daily intimate hygiene...
April 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29441466/hyaluronic-acid-grafted-plga-nanoparticles-for-the-sustained-delivery-of-berberine-chloride-for-an-efficient-suppression-of-ehrlich-ascites-tumors
#7
Priyanka Bhatnagar, Manisha Kumari, Richa Pahuja, A B Pant, Y Shukla, Pradeep Kumar, K C Gupta
To promote the specific targeting and elimination of CD44-positive cancer cells, berberine chloride (BRB)-encapsulated hyaluronic acid-grafted poly(lactic-co-glycolic acid) copolymer (BRB-d(HA)-g-PLGA) nanoparticles (NPs) were prepared. The targeted action of these NPs was compared to non-targeted BRB-loaded PLGA NPs and bulk BRB. The in vitro studies demonstrated faster release of BRB and increased cytotoxicity of BRB-d(HA)-g-PLGA NPs in Hela and MCF-7 cells in comparison to BRB-PLGA NPs and bulk BRB. The uptake of BRB-d(HA)-g-PLGA NPs was increased in case of MCF-7 cells as compared to HeLa cells owing to the higher expression of CD44 receptors on MCF-7 cells...
February 13, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29440702/a-fluidic-device-for-the-controlled-formation-and-real-time-monitoring-of-soft-membranes-self-assembled-at-liquid-interfaces
#8
Arturo Mendoza-Meinhardt, Lorenzo Botto, Alvaro Mata
Membrane materials formed at the interface between two liquids have found applications in a large variety of technologies, from sensors to drug-delivery and catalysis. However, studying the formation of these membranes in real-time presents considerable challenges, owing to the difficulty of prescribing the location and instant of formation of the membrane, the difficulty of observing time-dependent membrane shape and thickness, and the poor reproducibility of results obtained using conventional mixing procedures...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440656/gold-nanoparticle-based-rapid-detection-and-isolation-of-cells-using-ligand-receptor-chemistry
#9
Pradipta Ranjan Rauta, Pavan M Hallur, Aditya Chaubey
Identification and isolation of low-frequency cells of interest from a heterogeneous cell mixture is an important aspect of many diagnostic applications (including enumeration of circulating tumor cells) and is integral to various assays in (cancer) biology. Current techniques typically require expensive instrumentation and are not amenable to high throughput. Here, we demonstrate a simple and effective platform for cell detection and isolation using gold nanoparticles (Au NPs) conjugated with hyaluronic acid (HA) i...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29438204/effects-of-hyaluronic-acid-and-hydroxyapatite-beta-tricalcium-phosphate-in-combination-on-bone-regeneration-of-a-critical-size-defect-in-an-experimental-model
#10
Nurettin Diker, Serap Gulsever, Taner Koroglu, Eda Yilmaz Akcay, Yener Oguz
Hyaluronic acid (HyA) is an outstanding new product in the field of oral and maxillofacial surgery. The aim of this study was to evaluate the effects of HyA on bone regeneration in critical-size calvarial defects. Twenty-four female Sprague-Dawley rats were used in the present study. In each rat, 4 critical-size defects received different treatments: no treatment (control); HyA; Graft; and HyA + Graft combination. New bone formation, defect closure, inflammation, vascular proliferation, immature bone formation, mature bone formation, and bone marrow existence were investigated based on histological findings...
February 12, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29436217/a-stealth-and-fully-laden-drug-carrier-self-assembled-nanogel-encapsulated-with-epigallocatechin-gallate-and-sirna-for-drug-resistant-breast-cancer-therapy
#11
Jie Ding, Tingxizi Liang, Qianhao Min, Li-Ping Jiang, Jun-Jie Zhu
For co-delivery of therapeutic genes and chemical agents in combined therapy, the ideal drug delivery system (DDS) entails high-capacity and low-body toxicity carriers, allowing adequate drug dose for tumor region while yielding low residue in normal tissue. To augment the gene/drug load capacity and circumvent the potential toxicity brought by traditional inorganic and polymeric nanocarriers, a "stealth" carrier was herein designed in a simple self-assembly of (-)-epigallocatechin-3-O-gallate (EGCG) and small interfering RNA (siRNA) by recruiting protamine as biodegradable medium for the treatment of drug-resistant triple-negative breast cancer (TNBC)...
February 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29436209/focus-on-gastroesophageal-reflux-ger-and-laryngopharyngeal-reflux-lpr-new-pragmatic-insights-in-clinical-practice
#12
M Gelardi, G Ciprandi
Gastroesophageal reflux (GER) is a common disease usually limited to the oesophagus. Laryngopharyngeal reflux (LPR) is an inflammatory reaction of the mucosa of pharynx, larynx, and other associated upper respiratory organs, caused by a reflux of stomach contents outside the oesophagus. LPR is considered to be a relatively new clinical entity with a vast number of clinical manifestations which are treated sometimes empirically and without a correct diagnosis. However, there is disagreement between specialists about its definition and management: gastroenterologists consider LPR to be a substantially rare manifestation of gastroesophageal reflux disease (GERD), whereas otolaryngologists believe that LPR is an independent, but common in their practice, disorder...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29433060/dual-tumor-targeted-multifunctional-magnetic-hyaluronic-acid-micelles-for-enhanced-mr-imaging-and-combined-photothermal-chemotherapy
#13
Shaohui Zheng, Jiwon Han, Zhen Jin, Chang-Sei Kim, Sukho Park, Kyu-Pyo Kim, Jong-Oh Park, Eunpyo Choi
Multifunctional polymeric micelles were developed as a promising dual tumor-targeted drug delivery platform for magnetic resonance (MR) imaging and combined photothermal-chemotherapy. HA-C16 copolymers were synthesized via peptide formation process with subsequent co-encapsulation of therapeutic agent docetaxel (DTX) and superparamagnetic iron oxide nanoparticles (SPIONs) to form the multifunctional micelles. The micelles exhibited uniform nanosize and remarkable colloidal stability in aqueous solution. The sustained drug release behavior from HA micelles was observed over the test period...
February 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29429747/treatment-of-corneal-chemical-alkali-burns-with-a-crosslinked-thiolated-hyaluronic-acid-film
#14
Gina L Griffith, Barbara Wirostko, Hee-Kyoung Lee, Lauren E Cornell, Jennifer S McDaniel, David O Zamora, Anthony J Johnson
PURPOSE: The study objective was to test the utilization of a crosslinked, thiolated hyaluronic acid (CMHA-S) film for treating corneal chemical burns. METHODS: Burns 5.5mm in diameter were created on 10 anesthetized, male New Zealand white rabbits by placing a 1N NaOH soaked circular filter paper onto the cornea for 30s. Wounds were immediately rinsed with balanced salt solution (BSS). CMHA-S films were placed in the left inferior fornix of five injured and five uninjured animals...
February 8, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29429372/anti-inflammatory-effects-of-intra-articular-hyaluronic-acid-a-systematic-review
#15
Roy Altman, Asheesh Bedi, Ajay Manjoo, Faizan Niazi, Peter Shaw, Philip Mease
Objective Osteoarthritis (OA) is one of the leading causes of disability in the adult population. Common nonoperative treatment options include nonsteroidal anti-inflammatory drugs (NSAIDs), intra-articular corticosteroids, and intra-articular injections of hyaluronic acid (HA). HA is found intrinsically within the knee joint providing viscoelastic properties to the synovial fluid. HA therapy provides anti-inflammatory relief through a number of different pathways, including the suppression of pro-inflammatory cytokines and chemokines...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29426836/combinatorial-hydrogels-with-biochemical-gradients-for-screening-3d-cellular-microenvironments
#16
Sebastián L Vega, Mi Y Kwon, Kwang Hoon Song, Chao Wang, Robert L Mauck, Lin Han, Jason A Burdick
3D microenvironmental parameters control cell behavior, but can be challenging to investigate over a wide range of conditions. Here, a combinatorial hydrogel platform is developed that uses light-mediated thiol-norbornene chemistry to encapsulate cells within hydrogels with biochemical gradients made by spatially varied light exposure. Specifically, mesenchymal stem cells are photoencapsulated in norbornene-modified hyaluronic acid hydrogels functionalized with gradients (0-5 mM) of peptides that mimic cell-cell or cell-matrix interactions, either as single or orthogonal gradients...
February 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29425717/localized-delivery-of-mirnas-targets-cyclooxygenases-and-reduces-flexor-tendon-adhesions
#17
Youlang Zhou, Qianqian Yang, Yingying Yan, Changlai Zhu, Luzhong Zhang, Jin Bo Tang
The formation of adhesions during healing of an injured tendon remains a difficult problem in clinical practice. Local anti-inflammation gene delivery provides high local gene concentration, reduces the inflammatory response of the injured tendon microenvironment, and decreases systemic side effects to enhance in vivo efficacy. In this study, we designed a novel local sustained gene delivery system by using cyclooxygenase (COX-1 and COX-2)-engineered miRNA plasmid/nanoparticles embedded in hyaluronic acid (HA) hydrogel to reduce flexor tendon adhesions...
February 6, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29424292/cross-linked-hyaluronan-films-loaded-with-acetazolamide-cyclodextrin-triethanolamine-complexes-for-glaucoma-treatment
#18
Javier Adrián Calles, Maria Julia Mora, Renée Onnainty, Luis Ignacio Tartara, Gladys Ester Granero, Marcela Raquel Longhi, Yolanda Diebold, Enrique Marcelo Vallés, Santiago Daniel Palma
AIM: This work aimed to design and characterize cross-linked hyaluronic acid-itaconic acid films loaded with acetazolamide-hydroxypropyl β cyclodextrin-triethanolamine complexes. MATERIALS & METHODS: Films were cross-linked with itaconic acid and poly(ethyleneglycol)-diglycidylether. Biopharmaceutical properties were assessed by evaluating in vitro drug release rate, biocompatibility in a human corneal epithelial cell line, bioadhesiveness with pig gastric mucin, in vivo bioadhesion and efficacy...
February 1, 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29423745/in-reply-to-commentary-to-endoscopic-and-clinical-benefits-of-hyaluronic-acid-in-children-with-chronic-adenoiditis-and-middle-ear-disease-by-zhengcai-lou
#19
S Torretta, P Marchisio, V Rinaldi, D Carioli, E Nazzari, L Pignataro
Some considerations will be expressed in consideration of the commentary previously published. In particular, we underline that no other medications were administered to the patients during the study period and any clinical evaluation was postponed in case of acute upper respiratory tract infection in the previous 14 days. We strongly advocate antibiotic treatment during any acute otitis media episode, and we agree that topically administered hyaluronic acid should be considered as a supporting treatment, "complementary to traditional therapies" in children with recurrent disease...
February 8, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29423470/a-turn-off-red-emitting-fluorophore-for-nanomolar-detection-of-heparin
#20
Palash Jana, Mithun Radhakrishna, Saumyakanti Khatua, Sriram Kanvah
A simple fluorophore bearing a diethylaminocoumarin donor and a pyridinium acceptor was synthesized and utilized for the ultra-sensitive detection of heparin. The synthesized dicationic push-pull coumarin derivative emits strongly in the red-region (665 nm) and detects nanomolar concentrations (14.8 nM to 148 nM) of heparin in HEPES buffer and FBS serum solutions. The dication exhibits excellent fluorescence selectivity and sensitivity towards heparin over its analogues such as chondroitin 4-sulfate (CS), hyaluronic acid (HA) and dextran...
February 9, 2018: Physical Chemistry Chemical Physics: PCCP
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