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Hyaluronic acid

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https://www.readbyqxmd.com/read/29222545/coefficient-of-friction-between-carboxymethylated-hyaluronic-acid-based-polymer-films-and-the-ocular-surface
#1
Jourdan Colter, Barbara Wirostko, Brittany Coats
Purpose: Hyaluronic acid-based polymer films are emerging as drug-delivery vehicles for local and continuous drug administration to the eye. The highly lubricating hyaluronic acid increases comfort, but displaces films from the eye, reducing drug exposure and efficacy. Previous studies have shown that careful control of the surface interaction of the film with the eye is critical for improved retention. Methods: In this study, the frictional interaction of a carboxymethylated, hyaluronic acid-based polymer (CMHA-S) with and without methylcellulose was quantified against ovine and human sclera at three axial loads (0...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29220165/photo-triggered-n2-generating-submicron-particles-for-selective-killing-of-cancer-cells
#2
Huiying Li, Wenbo Zhang, Ning He, Weijun Tong, Changyou Gao
Killing of cancer cells by applying mechanical disruption is an appealing emerging strategy for cancer treatment in recent years. In this study, photo-responsive submicron particles based on diazo-resin (DZR) which are able to release N2 under UV irradiation were prepared through a polyamine-salt aggregation method. After surface modification with hyaluronic acid (HA), the particles could be internalized selectively by cancer cells and mainly located in lysosomes after 6 h incubation. The viability of cancer cells decreased obviously after co-cultured with photo-responsive particles and UV irradiation due to the integrity damage of lysosomes by photo-triggered N2 generation and the subsequential increased reactive oxygen species...
December 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29219792/-unilateral-blindness-following-a-non-surgical-rhinoplasty-with-filler
#3
L W Schelke, M Fick, L J van Rijn, T Decates, P J Velthuis, F Niessen
BACKGROUND: A rare but known adverse event following a cosmetic filler treatment is unilateral blindness. In the Netherlands, this complication has not been reported in a patient before. CASE DESCRIPTION: A 26-year-old woman developed unilateral blindness after undergoing a cosmetic treatment of the dorsum nasi in which hyaluronic acid was used as filler. The blindness was caused by backflow of the filler via the ophthalmic artery into the carotid internal artery...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29219021/review-of-the-mechanism-of-action-for-supartz-fx-in-knee-osteoarthritis
#4
Roy D Altman, Vinod Dasa, Jun Takeuchi
Objective Summarize the biologic effects of Supartz FX for knee osteoarthritis (OA), the first worldwide clinically approved intra-articular (IA) hyaluronic acid (HA) product. Design To determine the mechanism of action from preclinical and clinical studies, a literature search was conducted of Supartz FX using academic databases from 1987 to 2016. Articles on Supartz FX that deal with its mechanisms of action were extracted, categorized, and reviewed. Results Supartz FX has 2 potential mechanisms of action: (1) biomechanical: IA Supartz FX directly improves the viscoelasticity and lubrication of synovial fluid; (2) physiologic: IA Supartz FX penetrates synovium and cartilage tissues to reach HA receptors on the surface of synoviocytes and chondrocytes...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29218478/the-rejuvenating-effect-and-tolerability-of-an-auto-cross-linked-hyaluronic-acid-on-d%C3%A3-colletage-a-pilot-prospective-study
#5
Andrea Alessandrini, Kseniya Tretyakova
BACKGROUND: A novel auto-cross-linked hyaluronic acid formulation (HA-ACP) has been proposed as a treatment for skin rejuvenation. This prospective pilot study aims to assess its tolerability and performance in the treatment of skin aging of the décolletage. METHODS: Fifteen women (mean age 49.0 ± 8.0  (range 30-65)) who complained about the appearance of their décolletage were prospectively enrolled and treated with three sets of HA-ACP (IAL-SYSTEM ACP®) intradermal injections, administered three weeks apart...
December 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29217906/liquid-paraffin-vs-hyaluronic-acid-in-preventing-intraperitoneal-adhesions
#6
Hanish Kataria, Vinod Prem Singh
Adhesion formation after abdominal and pelvic operations remains a challenging problem. Role of adjuvant barriers have been studied but there is no comparative study between liquid paraffin and hyaluronic acid as a barrier method. Hence, we planned to compare the effectiveness of 0.4 % hyaluronic acid and liquid paraffin in the prevention of postoperative intraperitoneal adhesions in rats. This prospective, randomized and controlled study was conducted in 60 adult Wistar albino rats. Surgical trauma by caecal abrasion and 1 g talcum powder was used in the rat model to induce adhesion formation...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29216721/alpha-2-macroglobulin-and-hyaluronic-acid-as-fibromarkers-in-patients-with-chronic-hepatitis-c
#7
B Pitekova, V Kupcova, E Uhlikova, V Mojto, L Turecky
BACKGROUND: Liver fibrosis is the final common pathway of chronic liver diseases of various etiology. From the practical standpoint, it would be ideal to have a noninvasive fibromarker. The aim of our study was to investigate the levels of alpha-2-macroglobulin, potential fibromarker, in correlation to histological staging and another potential fibromarker, hyaluronic acid, in patients with chronic hepatitis C. METHODS: Population groups in this study consisted of 51 healthy volunteers and 54 patients with chronic hepatitis C...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29215573/the-use-of-liposomes-and-nanoparticles-as-drug-delivery-systems-to-improve-cancer-treatment-in-dogs-and-cats
#8
REVIEW
Katarzyna Zabielska-Koczywąs, Roman Lechowski
BACKGROUND: Cancer remains a leading cause of death in companion animals. In human medicine, liposomes and nanoparticles have been extensively investigated as drug delivery systems (DDS) for anticancer agents due to their ability to target cancerous cells and reduce the negative side effects of free cytostatic drugs. In this review, the authors discuss the results of clinical trials using liposomes and polymer-based nanoparticles as DDS to improve cancer treatment in dogs and cats, indicating which ones seem worth further evaluation...
December 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29215050/tumor-necrosis-factor-alpha-regulates-photoreceptor-cell-autophagy-after-retinal-detachment
#9
Jia Xie, Ruilin Zhu, Yuan Peng, Wenna Gao, Jiantong Du, Liang Zhao, Ying Chi, Liu Yang
Photoreceptor cell death is the ultimate process underlying many retinal diseases, including retinal detachment (RD). Both autophagy and inflammatory factors, such as tumor necrosis factor-alpha (TNF-α), participate in photoreceptor cell death after RD. In this study, we examined whether TNF-α inhibition would impact the autophagy of photoreceptors and reduce the death of photoreceptors after retinal detachment (RD). RD models were created in C57BL/6J mice by a subretinal injection of 1% hyaluronic acid. The TNF-α inhibitor infliximab was administered via intraperitoneal injection two hours before RD...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214232/hybrid-protein-glycosaminoglycan-hydrogels-promote-chondrogenic-stem-cell-differentiation
#10
Vladimíra Moulisová, Sara Poveda-Reyes, Esther Sanmartín-Masiá, Luis Quintanilla-Sierra, Manuel Salmerón-Sánchez, Gloria Gallego Ferrer
Gelatin-hyaluronic acid (Gel-HA) hybrid hydrogels have been proposed as matrices for tissue engineering because of their ability to mimic the architecture of the extracellular matrix. Our aim was to explore whether tyramine conjugates of Gel and HA, producing injectable hydrogels, are able to induce a particular phenotype of encapsulated human mesenchymal stem cells without the need for growth factors. While pure Gel allowed good cell adhesion without remarkable differentiation and pure HA triggered chondrogenic differentiation without cell spreading, the hybrids, especially those rich in HA, promoted chondrogenic differentiation as well as cell proliferation and adhesion...
November 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/29212185/hyaluronic-acid-enhances-cell-migration-and-invasion-via-the-yap1-taz-rhamm-axis-in-malignant-pleural-mesothelioma
#11
Wataru Shigeeda, Masahiko Shibazaki, Shinji Yasuhira, Tomoyuki Masuda, Tatsuo Tanita, Yuka Kaneko, Tatsuhiro Sato, Yoshitaka Sekido, Chihaya Maesawa
Most malignant mesotheliomas (MPMs) frequently show activated forms of Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ), which transcriptionally regulates the receptor for hyaluronic acid-mediated motility (RHAMM). As RHAMM is involved in cell migration and invasion in various tumors, we speculated that hyaluronic acid (HA) in pleural fluid might affect the progression of mesothelioma by stimulating cell migration and invasion through RHAMM. The level of RHAMM expression was decreased by YAP1/TAZ knockdown, and conversely increased by forced expression of the active form of YAP1, suggesting that RHAMM was regulated by YAP1/TAZ in MPM cells...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29210138/endovascular-shedding-markers-in-patients-with-heart-failure-with-reduced-ejection-fraction
#12
Petra Nijst, Jirka Cops, Pieter Martens, Quirine Swennen, Matthias Dupont, W H Wilson Tang, Wilfried Mullens
BACKGROUND: Endothelial glycocalyx degradation has been associated with multiple pathophysiological processes in cardiovascular disease. AIMS: To explore the role of glycocalyx shedding markers in pathophysiology of heart failure with reduced ejection fraction (HFrEF). METHODS: In 123 HFrEF patients the concentration, prognostic value and association of glycocalyx shedding markers with other disease processes was investigated. RESULTS: Median hyaluronic acid (HA) levels and syndecan-1 levels in HFrEF patients were respectively 29...
December 6, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29209879/one-pot-analysis-of-sulfated-glycosaminoglycans
#13
C B Shrikanth, J Sanjana, Nandini D Chilkunda
Routine isolation, estimation, and characterization of glycosaminoglycans (GAGs) is quite challenging. This is compounded by the fact that the analysis is technique-intensive and more often there will be a limitation on the quantity of GAGs available for various structural, functional and biological studies. In such a scenario, the sample which can be made available for estimation and elucidation of disaccharide composition and species composition as well remains a challenge. In the present study, we have determined the feasibility where isolated sulfated GAGs (sGAG) that is estimated by metachromasia is recovered for further analysis...
December 5, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/29209316/complement-protein-c1q-binds-to-hyaluronic-acid-in-the-malignant-pleural-mesothelioma-microenvironment-and-promotes-tumor-growth
#14
Chiara Agostinis, Romana Vidergar, Beatrice Belmonte, Alessandro Mangogna, Leonardo Amadio, Pietro Geri, Violetta Borelli, Fabrizio Zanconati, Francesco Tedesco, Marco Confalonieri, Claudio Tripodo, Uday Kishore, Roberta Bulla
C1q is the first recognition subcomponent of the complement classical pathway, which acts toward the clearance of pathogens and apoptotic cells. C1q is also known to modulate a range of functions of immune and non-immune cells, and has been shown to be involved in placental development and sensorial synaptic pruning. We have recently shown that C1q can promote tumor by encouraging their adhesion, migration, and proliferation in addition to angiogenesis and metastasis. In this study, we have examined the role of human C1q in the microenvironment of malignant pleural mesothelioma (MPM), a rare form of cancer commonly associated with exposure to asbestos...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29208903/a-novel-bioreactor-system-for-biaxial-mechanical-loading-enhances-the-properties-of-tissue-engineered-human-cartilage
#15
Christoph Meinert, Karsten Schrobback, Dietmar W Hutmacher, Travis J Klein
The ex vivo engineering of autologous cartilage tissues has the potential to revolutionize the clinical management of joint disorders. Yet, high manufacturing costs and variable outcomes associated with tissue-engineered implants are still limiting their application. To improve clinical outcomes and facilitate a wider use of engineered tissues, automated bioreactor systems capable of enhancing and monitoring neotissues are required. Here, we developed an innovative system capable of applying precise uni- or biaxial mechanical stimulation to developing cartilage neotissues in a tightly controlled and automated fashion...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208701/interleukin-23-regulates-interleukin-17-expression-in-wounds-and-its-inhibition-accelerates-diabetic-wound-healing-through-the-alteration-of-macrophage-polarization
#16
James Lee, Mathieu Paul Rodero, Jatin Patel, Davide Moi, Roberta Mazzieri, Kiarash Khosrotehrani
Inflammation is a critical phase in the healing of skin wounds. Excessive inflammation and inflammatory macrophages are known to cause impaired wound closure and outcome. This prompted us to test the role of IL-23 in IL-17 expression and in modulating wound inflammation and macrophage polarization. Full-thickness wounds (4 × 6 mm) were created on the dorsal surface of multiple genetically modified mouse models. Obese diabetic mouse wounds were treated with anti-IL-17A, anti-IL-23, or isotype-matched antibodies...
December 5, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29208274/hemostatic-porous-sponges-of-cross-linked-hyaluronic-acid-cationized-dextran-by-one-self-foaming-process
#17
Jia-Ying Liu, Yang Li, Yang Hu, Gang Cheng, Enyi Ye, Chuanan Shen, Fu-Jian Xu
Effective hemostatic materials are very important for treating trauma cases. Natural polysaccharides have been particularly appealing in the development of new hemostatic materials due to their unique functions in human bodies. In this work, different polysaccharide-based hemostatic porous sponges (SHDP or SHDQ) of cross-linked hyaluronic acid (HA)/cationized dextran were readily prepared by the self-foaming process of HA and poly((2-dimethyl amino)-ethyl methacrylate)-grafted dextran (Dex-PDM) or partially-quaternized Dex-PDM in the presence of sodium trimetaphosphate crosslinkers...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29204575/healing-of-the-nasal-septal-mucosa-in-an-experimental-rabbit-model-of-mucosal-injury
#18
Kyu Young Choi, Sung Woo Cho, Jun-Jae Choi, Yu-Lian Zhang, Dae Woo Kim, Doo Hee Han, Hyun Jik Kim, Dong-Young Kim, Chae-Seo Rhee, Tae-Bin Won
Objective: The aim of this study was to investigate the regeneration process of the nasal mucosa after a surgically created mucosal defect in the rabbit nasal septum, and to evaluate the effects of different interventions. Methods: A 7 mm-diameter circular mucosal defect was made in the septum of forty New Zealand white rabbits. The rabbits were divided into four groups (ten rabbits in each group) according to the type of intervention; no treatment (control), silastic sheet (SS), hyaluronic acid (HA), and silastic sheet and hyaluronic acid (SS + HA) group...
March 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29204424/3-d-bioprinting-of-neural-tissue-for-applications-in-cell-therapy-and-drug-screening
#19
REVIEW
Michaela Thomas, Stephanie M Willerth
Neurodegenerative diseases affect millions of individuals in North America and cost the health-care industry billions of dollars for treatment. Current treatment options for degenerative diseases focus on physical rehabilitation or drug therapies, which temporarily mask the effects of cell damage, but quickly lose their efficacy. Cell therapies for the central nervous system remain an untapped market due to the complexity involved in growing neural tissues, controlling their differentiation, and protecting them from the hostile environment they meet upon implantation...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29202575/biorevitalization-an-in-vitro-study-on-gingival-fibroblast
#20
A Palmieri, A Avantaggiato, F Cura, M Casale, M A Lopez, F Bressi, L Scapoli
Bio-revitalization is a therapy commonly used in aesthetic medicine to improve skin quality by di¬rectly integrating hyaluronic acid alone or added to other molecules (i.e. vitamins) through intradermal injections. These injections are not aimed to fill roughness but to achieve extracellular matrix optimi¬zation. The injective medical devices used in aesthetic medicine differ for hyaluronic acid content and for the presence of additional molecules that characterize the formulation of a particular company...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
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