keyword
MENU ▼
Read by QxMD icon Read
search

Hyaluronic acid

keyword
https://www.readbyqxmd.com/read/28821122/-click-hyaluronan-based-nanohydrogels-as-multifunctionalizable-carriers-for-hydrophobic-drugs
#1
Giuliana Manzi, Nicole Zoratto, Silvia Matano, Rocchina Sabia, Claudio Villani, Tommasina Coviello, Pietro Matricardi, Chiara Di Meo
Highly hydrophilic and biocompatible nanocarriers based on polysaccharide hydrogels (nanohydrogels, NHs) were shown to be promising systems for drug delivery applications. Following the idea of these emerging drug carriers, the aim of the present work was to develop self-assembled hydrogel nanoparticles based on amphiphilic derivatives of hyaluronic acid (HA) and riboflavin (Rfv), synthesized by "click" Copper(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC) reaction. The obtained amphiphilic product (HA-c-Rfv) was able to form nanohydrogels in aqueous environments, in particular by applying an innovative autoclave-based method...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28817072/efficient-transdermal-delivery-of-alendronate-a-nitrogen-containing-bisphosphonate-using-tip-loaded-self-dissolving-microneedle-arrays-for-the-treatment-of-osteoporosis
#2
Hidemasa Katsumi, Yutaro Tanaka, Kaori Hitomi, Shu Liu, Ying-Shu Quan, Fumio Kamiyama, Toshiyasu Sakane, Akira Yamamoto
To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)-MN). We observed micron-scale pores in rat skin just after application of ALN(TIP)-MN, indicating that transdermal pathways for ALN were created by MN. ALN was rapidly released from the tip of MNs as observed in an in vitro release study...
August 17, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28816102/hydrodenticity-to-enhance-relaxivity-of-gadolinium-dtpa-within-crosslinked-hyaluronic-acid-nanoparticles
#3
Maria Russo, Alfonso Maria Ponsiglione, Ernesto Forte, Paolo Antonio Netti, Enza Torino
AIM: The efficacy of gadolinium (Gd) chelates as contrast agents for magnetic resonance imaging remains limited owing to poor relaxivity and toxic effects. Here, the effect of the hydration of the hydrogel structure on the relaxometric properties of Gd-DTPA is explained for the first time and called Hydrodenticity. RESULTS: The ability to tune the hydrogel structure is proved through a microfluidic flow-focusing approach able to produce crosslinked hyaluronic acid nanoparticles, analyzed regarding the crosslink density and mesh size, and connected to the characteristic correlation times of the Gd-DTPA...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28814892/treatment-of-a-traumatic-atrophic-depressed-scar-with-hyaluronic-acid-fillers-a-case-report
#4
Syed Nazim Hussain, Greg J Goodman, Eqram Rahman
BACKGROUND: Hyaluronic acid filler has been documented in the treatment of atrophic depressed acne scars relatively frequently in the literature but rarely in chronic depressed traumatic atrophic facial scars. METHODS: This case report discusses the use of hyaluronic acid fillers in the correction of a post-traumatic facial atrophic scar on the right cheek. RESULTS: The right cheek scar was substantially corrected with one session of two different hyaluronic acids injected in a deep and superficial plane...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28814137/pegylated-crosslinked-hyaluronic-acid-nanoparticles-designed-through-a-microfluidic-platform-for-nanomedicine
#5
Maria Russo, Anna Maria Grimaldi, Paolo Bevilacqua, Olimpia Tammaro, Paolo Antonio Netti, Enza Torino
AIM: A high versatile microfluidic platform is proposed to design, in a one-step strategy, PEGylated crosslinked hyaluronic acid nanoparticles (cHANPs) entrapping a magnetic resonance imaging contrast agent and a dye for multimodal imaging applications. MATERIALS & METHODS: Clinically relevant biomaterials were shaped in the form of spherical NPs through a microfluidic flow focusing approach. A comparison between post processing and simultaneous PEGylation is reported to evaluate the potentiality of the chemical decoration of the cHANPs in microfluidics...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28814113/intracytoplasmic-sperm-injection-using-hyaluronic-acid-or-polyvinylpyrrolidone-a-time-lapse-sibling-oocyte-study
#6
Yanhe Liu, Katie Feenan, Vincent Chapple, Peter Roberts, Phillip Matson
This study evaluated the effect of sperm selection and intracytoplasmic sperm injection (ICSI) on subsequent fertilization and embryo development using the hyaluronic acid-based SpermSlow™ (HA-ICSI) compared to injection with polyvinylpyrrolidone (PVP-ICSI). A total of 206 metaphase II oocytes were collected from 21 prospectively enrolled ICSI cycles at Fertility North between July 2014 and March 2015. Sibling oocytes were randomized into HA-ICSI and PVP-ICSI (n = 103 per group). Subsequent fertilization outcomes and embryo development in terms of qualitative and quantitative time-lapse measures following three-day culture in the Embryoscope™ were compared...
August 17, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28810851/chitosan-in-viscosupplementation-in-vivo-effect-on-rabbit-subchondral-bone
#7
R Rieger, C Boulocher, S Kaderli, T Hoc
BACKGROUND: To investigate the effect of intra-articular injection of Chitosan (Cs) added to hyaluronic acid (HA) on subchondral bone during osteoarthritis (OA), microarchitectural parameters and mineral density were measured in a rabbit model of early OA. A novel hybrid hydrogel adding reacetylated Cs of fungal origin to HA was compared to high molecular weight HA commercial formulation. METHOD: Eighteen rabbits underwent unilateral anterior cruciate ligament transection (ACLT) and were divided into three groups (Saline-group, HA-group and Hybrid-group) depending on the intra-articular injection compound...
August 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28810659/hyaluronic-acid-conjugation-facilitates-clearance-of-intracellular-bacterial-infections-by-streptomycin-with-neglectable-nephrotoxicity
#8
Yuanhao Qiu, Yilin Hou, Feifei Sun, Peng Chen, Dongdong Wang, Haibo Mu, Xiaoli Zhang, Kan Ding, Jinyou Duan
Antibiotics such as β-lactams and aminoglycosides are often subtherapeutic to intracellular infections due to their high hydrophilicity, resulting in low effectiveness against intracellular pathogens and the emergence of antibiotic resistance. Here we reported that an endogenous aminoglycan, hyaluronic acid could be an effective carbohydrate carrier of the aminoglycoside antibiotic, streptomycin against intracellular pathogens. This conjugation could enhance phagocytic activity, and facilitated the entry of streptomycin into host cells via a CD44-mediated pathway...
September 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28810560/effects-of-taohongsiwu-decoction-on-the-expression-of-%C3%AE-sma-and-tgf-%C3%AE-1-mrna-in-the-liver-tissues-of-a-rat-model-of-hepatic-cirrhosis
#9
Tongsheng Wang, Deling Wu, Peipei Li, Ke Zhang, Shanjun Tao, Zhu Li, Jun Li
The present study aimed to explore the treatment effects of Taohongsiwu decoction on the liver fibrosis in a rat model, as few prior studies have investigated the anti-fibrotic effects of Taohongsiwu decoction. High-performance liquid chromatography was used to measure the concentration of ferulic acid and hydrosafflower flavin A in the decoction. Male Sprague-Dawley rats were randomly divided into control, model, colchicine (positive group), Taohongsiwu-high, Taohongsiwu-moderate and Taohongsiwu-low groups; 50% carbon tetrachloride (CCl4) of peanut oil solution was subcutaneously injected to the rats except for the control group, and the drugs were intragastrically administered (10 ml/kg) starting at week 7 for 6 continuous weeks...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28807118/efficacy-of-autologous-platelet-rich-plasma-combined-with-hyaluronic-acid-on-skin-facial-rejuvenation-a-prospective-study
#10
Barbara Hersant, Mounia SidAhmed-Mezi, Jeremy Niddam, Simone La Padula, Warren Noel, Khaled Ezzedine, Anne Marie Rodriguez, Jean Paul Meningaud
No abstract text is available yet for this article.
September 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28806066/thiol-mediated-synthesis-of-hyaluronic-acid-epigallocatechin-3-o-gallate-conjugates-for-the-formation-of-injectable-hydrogels-with-free-radical-scavenging-property-and-degradation-resistance
#11
Chixuan Liu, Ki Hyun Bae, Atsushi Yamashita, Joo Eun Chung, Motoichi Kurisawa
Hyaluronic acid (HA)-based biomaterials have demonstrated only limited in vivo stability as a result of rapid degradation by hyaluronidase and reactive oxidative species. The green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG), has received considerable attention because of its powerful antioxidant and enzyme-inhibitory activities. We describe here the synthesis of HA-EGCG conjugate using a thiol-mediated reaction and its use for the preparation of a long-lasting injectable hydrogel. HA-EGCG conjugates with tunable degrees of substitution were synthesized by the nucleophilic addition reaction between EGCG quinone and thiolated HA under mild conditions...
August 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28805867/coumarin-containing-thermoresponsive-hyaluronic-acid-based-nanogels-as-delivery-systems-for-anticancer-chemotherapy
#12
Talitha F Stefanello, Benoit Couturaud, Anna Szarpak-Jankowska, David Fournier, Benoit Louage, Francielle P Garcia, Celso V Nakamura, Bruno G De Geest, Patrice Woisel, Boudewijn van der Sanden, Rachel Auzély-Velty
Multi-stimuli responsive nanogels based on biocompatible hydrophilic polymers have emerged as promising drug delivery systems to improve anticancer therapy with hydrophobic drugs, through increase of circulating-time in the bloodstream, tumor-targeting and reduction of systemic toxicity. This paper reports on the synthesis, characterization and biological perspectives of light- and thermoresponsive hyaluronic acid (HA)-based nanogels containing coumarin as the photocleavable group. Newly synthesized nanogels exhibited interesting features: formation by a temperature-triggered self-assembly process, successful incorporation of poorly water-soluble molecules, light-responsiveness as demonstrated by a significant shift in the critical aggregation temperature after light irradiation, efficient internalization by cancer cells overexpressing the CD44 receptor of HA, ability to circulate for a prolonged period of time in the bloodstream after intravenous injection in mice and considerable detection in tumor tissues...
August 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28805098/assessment-of-the-permeability-and-toxicity-of-polymeric-nanocapsules-using-the-zebrafish-model
#13
Carmen Teijeiro-Valiño, Elena Yebra-Pimentel, Jorge Guerra-Varela, Noemi Csaba, María J Alonso, Laura Sánchez
AIM: To assess the capacity of a new drug delivery nanocapsule (NC) with a double shell of hyaluronic acid and protamine to overcome biological barriers using the zebrafish model. MATERIALS & METHODS: NCs were prepared by the solvent displacement method, tagged with fluorescent makers and physicochemically characterized. Toxicity was evaluated according to the Fish Embryo Acute Toxicity test, and permeability was tested by exposing zebrafish, with and without chorion, to the fluorescent NCs...
August 14, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28804933/chemical-functionalization-of-polysaccharides-towards-biocompatible-hydrogels-for-biomedical-applications
#14
Andreas Kirschning, Gerald Dräger, Nick Dibbert
Hydrogels have emerged as a highly interdisciplinary topic as they play a significant role for a vast number of applications. They have been studied extensively as materials for contact lenses, wound dressing and as filler material in soft-tissue augmentation, in which classical polymer backbones such as hydroxyethylmethacrylate (HEMA) are typically employed. More recently, polysaccharides have received attention, particularly in the fields of regenerative medicine and tissue engineering, as ideal candidate materials for artificial extracellular matrices (ECM)...
August 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28804742/immunological-reaction-after-facial-hyaluronic-acid-injection
#15
Antoine Homsy, Eva Meia Rüegg, Peter Jandus, Brigitte Pittet-Cuénod, Ali Modarressi
We report two rare cases of inflammatory reactions with multiple subcutaneous facial painful collections after Hyaluronic acid injections, expose their management and discuss aetiologic hypothesis. Due to unfavourable evolution despite antibiotic treatment, surgical drainage was performed. Immune-mediated delayed hypersensitivity reactions were the most probable cause.
2017: Case Reports in Plastic Surgery & Hand Surgery
https://www.readbyqxmd.com/read/28801676/hyaluronic-acid-coatings-as-a-simple-and-efficient-approach-to-improve-msc-homing-toward-the-site-of-inflammation
#16
Bruna Corradetti, Francesca Taraballi, Jonathan O Martinez, Silvia Minardi, Nupur Basu, Guillermo Bauza, Michael Evangelopoulos, Sebastian Powell, Claudia Corbo, Ennio Tasciotti
A major challenge in regenerative medicine is to improve therapeutic cells' delivery and targeting using an efficient and simple protocol. Mesenchymal stem cells (MSC) are currently employed for the treatment of inflammatory-based diseases, due to their powerful immunosoppressive potential. Here we report a simple and versatile method to transiently overexpress the hyaluronic acid (HA) receptor, CD44, on MSC membranes, to improve their homing potential towards an inflammatory site without affecting their behavior...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28799225/hydrogels-with-reversible-mechanics-to-probe-dynamic-cell-microenvironments
#17
Adrianne Rosales, Sebastian L Vega, Frank W DelRio, Jason A Burdick, Kristi S Anseth
The relationship between ECM mechanics and cell behavior is dynamic, as cells remodel and respond to changes in their local environment. Most in vitro substrates are static and supraphysiologically stiff; thus, platforms with dynamic and reversible mechanical changes are needed. Here, we developed hyaluronic acid-based substrates capable of sequential photodegradation and photoinitiated crosslinking reactions to "soften" and then "stiffen" the hydrogels over a physiologically-relevant range of moduli. Reversible mechanical signaling to adhered cells was demonstrated with human mesenchymal stem cells...
August 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28798857/the-role-of-shear-stress-and-altered-tissue-properties-on-endothelial-to-mesenchymal-transformation-and-tumor-endothelial-cell-interaction
#18
Sara G Mina, Peter Huang, Bruce T Murray, Gretchen J Mahler
Tumor development is influenced by stromal cells in aspects including invasion, growth, angiogenesis, and metastasis. Activated fibroblasts are one group of stromal cells involved in cancer metastasis, and one source of activated fibroblasts is endothelial to mesenchymal transformation (EndMT). EndMT begins when the endothelial cells delaminate from the cell monolayer, lose cell-cell contacts, lose endothelial markers such as vascular endothelial-cadherin (VE-cadherin), gain mesenchymal markers like alpha-smooth muscle actin (α-SMA), and acquire mesenchymal cell-like properties...
July 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28796122/ocular-surface-lubricants
#19
Leonard Bielory, Preeti Wagle
PURPOSE OF REVIEW: The purpose of this article is to provide an overview of the ocular lubricants currently available, consider the components of the various formulations and highlight the status of preservative use in the treatment of anterior ocular surface diseases. RECENT FINDINGS: The primary components of ocular surface lubrication have been, in the past, based on various cellulose formulations that increase hydration. Advances in lubrication have come from areas of the human body requiring lubrication such as the skeletal joints as well as examining the use of natural components of the tear fluid...
August 8, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28795878/effects-of-prisma%C3%A2-skin-dermal-regeneration-device-containing-glycosaminoglycans-on-human-keratinocytes-and-fibroblasts
#20
Raffaella Belvedere, Valentina Bizzarro, Luca Parente, Francesco Petrella, Antonello Petrella
Prisma® Skin is a new pharmaceutical device developed by Mediolanum Farmaceutici S.p.a. It includes alginates, hyaluronic acid and mainly mesoglycan. The latter is a natural glycosaminoglycan preparation containing chondroitin sulfate, dermatan sulfate, heparan sulfate and heparin and it is used in the treatment of vascular disease. Glycosaminoglycans may contribute to the re-epithelialization in the skin wound healing, as components of the extracellular matrix. Here we describe, for the first time, the effects of Prisma® Skin in in vitro cultures of adult epidermal keratinocytes and dermal fibroblasts...
August 10, 2017: Cell Adhesion & Migration
keyword
keyword
13636
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"