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https://www.readbyqxmd.com/read/29779201/clinical-acceptability-of-trimetazidine-modified-release-80-mg-once-daily-versus-trimetazidine-modified-release-35-mg-twice-daily-in-stable-angina-pectoris
#1
Yuri M Pozdnyakov
INTRODUCTION: Trimetazidine (TMZ) is an anti-ischemic metabolic agent that has been shown to be efficacious in angina treatment, both in monotherapy and in combination. A new formulation of TMZ modified-release (MR) 80 mg was developed, which is to be taken once daily (od), instead of twice daily (bid) for the currently available TMZ MR 35 mg, with the aim of simplifying the medication regimen. METHODS: The present study was an international, multicenter, randomized, double-blind, parallel-group phase III study with a 12-week treatment period...
May 19, 2018: Cardiology and Therapy
https://www.readbyqxmd.com/read/29779182/locator%C3%A2-versus-ceramic-electroplated-double-crown-attachments-a-prospective-study-on-the-intraindividual-comparison-of-implant-supported-mandibular-prostheses
#2
Silvia Brandt, Jan Brandt, Ali-Reza Ketabi, Hans-Christoph Lauer, Anna Kunzmann
OBJECTIVES: Implant-supported overdentures are an established dental treatment mode. The aim of this prospective study was and interindividual comparison of patient satisfaction with restorations retained by a prefabricated and thus inexpensive attachment system (Locator®) or with a technologically complex and thus expensive attachment system (ceramic/electroplated double crowns) with similar retentive performance. MATERIALS AND METHODS: Twelve patients received a Locator and a double-crown prosthesis in a crossover study for test periods of 3 months each...
May 19, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29779154/the-effect-of-meteorological-conditions-and-air-pollution-on-the-occurrence-of-type-a-and-b-acute-aortic-dissections
#3
Nan Xie, Liqun Zou, Lei Ye
To explore the association of weather conditions and air pollutants with incidence risk of acute aortic dissection (AAD), we included patients who consecutively admitted to the emergency units of our hospital for AAD between Dec. 1, 2013, and Apr. 30, 2017. Their medical records were reviewed. The meteorological data (daily precipitation, minimal and maximal temperatures, mean atmospheric pressure, relative humidity) and air pollutants values [air daily index (AQI), aerodynamic diameter of 2.5 mm or less (PM2...
May 19, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29779096/the-status-of-the-hemostasis-system-under-the-influence-of-proline-peptides-during-the-development-of-experimental-metabolic-syndrome
#4
M E Grigorjeva, N F Myasoedov, L A Lyapina, T Y Obergan, L A Andreeva
A comparative study of the influence of regulatory proline peptides Pro-Gly-Pro, Pro-Arg-Pro, Pro-Gly-Pro-Leu, and Arg-Pro-Gly-Pro on the state of the hemostasis system was carried out in an experiment on male rats with metabolic syndrome. Under these conditions, repeated (7-fold) intranasal administration of the peptides in a daily dose of 50 μg/kg resulted in an increase in the anticoagulant potential of the blood, namely, in an increase in the anticoagulant, fibrinolytic, and antiplatelet activity 20 h and 7 days after the last peptide injection...
March 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29779075/gardening-for-health-patterns-of-gardening-and-fruit-and-vegetable-consumption-among-the-navajo
#5
India J Ornelas, Katie Osterbauer, Lisa Woo, Sonia K Bishop, Desiree Deschenie, Shirley A A Beresford, Kevin Lombard
American Indians, including Navajo, are disproportionately affected by obesity and diabetes, in part due to diet-related health behaviors. The purpose of this study was to assess the patterns of gardening and fruit and vegetable (FV) consumption among residents in two communities on the Navajo Nation in order to inform a community gardening intervention. We analyzed survey data collected from participants in the Yéego Gardening study conducted in two communities in the Navajo Nation (N = 169). We found that 51% of the sample gardened, and on average participants gardened 8...
May 19, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29779024/a-randomized-clinical-trial-of-metformin-to-treat-autosomal-dominant-polycystic-kidney-disease
#6
Stephen L Seliger, Kaleab Z Abebe, Kenneth R Hallows, Dana C Miskulin, Ronald D Perrone, Terry Watnick, Kyongtae Tae Bae
BACKGROUND: Metformin inhibits cyclic AMP generation and activates AMP-activated protein kinase (AMPK), which inhibits the cystic fibrosis transmembrane conductance regulator and Mammalian Target of Rapamycin pathways. Together these effects may reduce cyst growth in autosomal dominant polycystic kidney disease (ADPKD). METHODS: A phase II, double-blinded randomized placebo-controlled trial of 26 months duration. Participants will include nondiabetic adults (n = 96) aged 18-60 years, with an estimated glomerular filtration rate (eGFR) ≥50 mL/min/1...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29779012/adaptive-frameworks-of-chronic-pain-daily-remakings-of-pain-and-care-at-a-somali-refugee-women-s-health-centre
#7
Kari Campeau
Pain is an intensely subjective experience and one that is difficult for healthcare professionals to treat. Chronic pain, often diffuse, cyclical and involving many systems of the body, is often not well treated in a medical system that relies on discrete symptoms, identifiable causes, external pathogens and physician specialisation. Pain has its own problems specific to Somali diaspora populations, where chronic pain is prevalent but often undertreated, and where Somali patients face barriers of access to medicine...
May 19, 2018: Medical Humanities
https://www.readbyqxmd.com/read/29778956/health-risk-assessment-of-heavy-metals-in-atmospheric-deposition-in-a-congested-city-environment-in-a-developing-country-kandy-city-sri-lanka
#8
Lakshika Weerasundara, D N Magana-Arachchi, Abdul M Ziyath, Ashantha Goonetilleke, Meththika Vithanage
This research study which was undertaken in a congested city environment in a developing country provides a robust approach for the assessment and management of human health risk associated with atmospheric heavy metals. The case study area was Kandy City, which is the second largest city in Sri Lanka and bears the characteristics of a typical city in the developing world such as the urban footprint, high population density and traffic congestion. Atmospheric deposition samples were collected on a weekly basis and analyzed for nine heavy metals common to urban environments, namely, Al, Cr, Mn, Fe, Ni, Cu, Zn, Cd and Pb...
May 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29778950/efficacy-of-educational-intervention-to-improve-awareness-of-the-importance-of-iodine-use-of-iodized-salt-and-dietary-iodine-intake-in-northeastern-italian-schoolchildren
#9
Sara Watutantrige-Fernando, Susi Barollo, Loris Bertazza, Elisabetta Cavedon, Simona Censi, Jacopo Manso, Federica Vianello, Caterina Mian
OBJECTIVE: An educational program was conducted among school-aged children to improve their knowledge about iodine prophylaxis, their iodine status, and their dietary habits. METHODS: At the baseline (T0) and after 6 mo (T1), participants (970 at T0 and 949 at T1) answered questionnaires testing their knowledge about iodine prophylaxis and their eating habits. Urine samples were collected from a randomly selected subgroup of participants (313 at T0 and 312 at T1)...
March 23, 2018: Nutrition
https://www.readbyqxmd.com/read/29778936/timed-instrumental-activities-of-daily-living-in-multiple-sclerosis-the-test-of-everyday-cognitive-ability-teca
#10
Leigh E Charvet, Michael T Shaw, Kathleen Sherman, Shannon Haas, Lauren B Krupp
OBJECTIVE: Cognitive impairment is a common symptom of multiple sclerosis (MS) that can lead to declines in daily functioning. Timed instrumental activities of daily living (TIADLs) have been useful to bridge between cognitive testing and real-world functioning in disorders such as Alzheimer's disease and other dementias. However, these have not been standardized for general use, and the tasks that are typically employed have not been sensitive to the detection of milder forms of cognitive deficits...
May 3, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29778885/effects-of-hyperpolypharmacy-and-potentially-inappropriate-medications-pims-on-functional-decline-in-older-patients-discharged-from-acute-care-hospitals
#11
Paolo Fabbietti, Carmelinda Ruggiero, Federica Sganga, Sergio Fusco, Federica Mammarella, Norma Barbini, Laura Cassetta, Graziano Onder, Andrea Corsonello, Fabrizia Lattanzio, Mirko Di Rosa
AIM: To comparatively investigate the effects of hyperpolypharmacy and potentially inappropriate medications (PIMs) on functional decline in older patients after hospital discharge. METHODS: Our series consisted of 733 patients aged ≥65 consecutively enrolled in a multicenter observational longitudinal study. PIMs were defined on the basis of updated versions of Beers and STOPP criteria. The occurrence of functional decline was defined as the loss of independency in at least 1 basic activity of daily living (BADL) from discharge through 3-month follow-up visit...
May 16, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29778830/wearable-camera-derived-microenvironments-in-relation-to-personal-exposure-to-pm-2-5
#12
Maëlle Salmon, Carles Milà, Santhi Bhogadi, Srivalli Addanki, Pavitra Madhira, Niharika Muddepaka, Amaravathi Mora, Margaux Sanchez, Sanjay Kinra, V Sreekanth, Aiden Doherty, Julian D Marshall, Cathryn Tonne
Data regarding which microenvironments drive exposure to air pollution in low and middle income countries are scarce. Our objective was to identify sources of time-resolved personal PM2.5 exposure in peri-urban India using wearable camera-derived microenvironmental information. We conducted a panel study with up to 6 repeated non-consecutive 24 h measurements on 45 participants (186 participant-days). Camera images were manually annotated to derive visual concepts indicative of microenvironments and activities...
May 17, 2018: Environment International
https://www.readbyqxmd.com/read/29778819/detection-of-tem-and-ctx-m-genes-from-ciprofloxacin-resistant-proteus-mirabilis-and-escherichia-coli-isolated-on-urinary-tract-infections-utis
#13
Govindan Rajivgandhi, Muthuchamy Maruthupandy, Natesan Manoharan
The multidrug resistant Gram negative bacteria (MDRGNB) is an emerging burden and now represents a daily challenge for the management of antimicrobial therapy in healthcare settings. The present study was aimed to detect the prevalence of TEM and CTX-M type genes from GNB on urinary tract infection (UTIs). The ciprofloxacin resistant uropathogens were detected by HEXA UTI 5 disc diffusion method. The phenotypic detection of uropathogens producing extended spectrum beta lactamases (ESBLs) was confirmed by double disc combination (DDCT) and phenotype confirmation methods (PCT)...
May 17, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29778811/associations-between-daily-outpatient-visits-for-respiratory-diseases-and-ambient-fine-particulate-matter-and-ozone-levels-in-shanghai-china
#14
Yiyi Wang, Yaqun Zu, Lin Huang, Hongliang Zhang, Changhui Wang, Jianlin Hu
Air pollution in China has been very serious during the recent decades. However, few studies have investigated the effects of short-term exposure to PM2.5 and O3 on daily outpatient visits for respiratory diseases. We examined the effects of PM2.5 and O3 on the daily outpatient visits for respiratory diseases, explored the sensitivities of different population subgroups and analyzed the relative risk (RR) of PM2.5 and O3 in different seasons in Shanghai during 2013-2016. The generalized linear model (GLM) was applied to analyze the exposure-response relationship between air pollutants (daily average PM2...
May 17, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29778792/valproic-acid-attenuates-manganese-induced-reduction-in-expression-of-glt-1-and-glast-with-concomitant-changes-in-murine-dopaminergic-neurotoxicity
#15
James Johnson, Edward Pajarillo, Pratap Karki, Judong Kim, Deok-Soo Son, Michael Aschner, Eunsook Lee
Exposure to elevated levels of manganese (Mn) causes manganism, a neurological disorder with similar characteristics to those of Parkinson's disease (PD). Valproic acid (VPA), an antiepileptic, is known to inhibit histone deacetylases and exert neuroprotective effects in many experimental models of neurological disorders. In the present study, we investigated if VPA attenuated Mn-induced dopaminergic neurotoxicity and the possible mechanisms involved in VPA's neuroprotection, focusing on modulation of astrocytic glutamate transporters (glutamate aspartate transporter, GLAST and glutamate transporter 1, GLT-1) and histone acetylation in H4 astrocyte culture and mouse models...
May 17, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29778755/development-and-acceptability-assessment-of-a-self-management-intervention-to-prevent-acute-to-chronic-pain-transition-after-major-lower-extremity-trauma
#16
Mélanie Bérubé, Céline Gélinas, Géraldine Martorella, Nancy Feeley, José Côté, George-Yves Laflamme, Dominique M Rouleau, Manon Choinière
Transition from acute to chronic pain often occurs after major lower extremity trauma. Chronic pain has been found to negatively affect daily functioning, including the capacity to work and quality of life. Empirical data and an acceptability assessment were used to develop a self-management intervention aimed at preventing acute to chronic pain transition after major lower extremity trauma (i.e., iPACT-E-Trauma). Evidence from previous studies on preventive self-management interventions, combined with a biopsychosocial conceptual framework and clinical knowledge, helped define the key features of the preliminary version...
May 16, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29778752/tools-to-assess-living-with-a-chronic-illness-a-systematic-review
#17
Leire Ambrosio, Mari Carmen Portillo
OBJECTIVE: To analyse the currently available instruments to assess living with a chronic illness and related aspects. METHOD: A review of the evidence was made using the databases: Medline, CINHAL, PsycINFO, Cochrane Library, Embase and Cuiden. The criteria that limited the search were: the language, English and / or Spanish and studies carried out in an adult population. Years of article publication were not used as a limit. RESULTS: A total of 16 instruments were identified and analysed that apparently measured the concept of living with a chronic illness and/or related aspects...
May 16, 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29778680/land-use-regression-models-to-assess-air-pollution-exposure-in-mexico-city-using-finer-spatial-and-temporal-input-parameters
#18
Yeongkwon Son, Álvaro R Osornio-Vargas, Marie S O'Neill, Perry Hystad, José L Texcalac-Sangrador, Pamela Ohman-Strickland, Qingyu Meng, Stephan Schwander
The Mexico City Metropolitan Area (MCMA) is one of the largest and most populated urban environments in the world and experiences high air pollution levels. To develop models that estimate pollutant concentrations at fine spatiotemporal scales and provide improved air pollution exposure assessments for health studies in Mexico City. We developed finer spatiotemporal land use regression (LUR) models for PM2.5 , PM10 , O3 , NO2 , CO and SO2 using mixed effect models with the Least Absolute Shrinkage and Selection Operator (LASSO)...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29778628/environmentally-enriched-pigs-have-transcriptional-profiles-consistent-with-neuroprotective-effects-and-reduced-microglial-activity
#19
S M Brown, S J Bush, K M Summers, D A Hume, A B Lawrence
Environmental enrichment (EE) is widely used to study the effects of external factors on brain development, function and health in rodent models, but very little is known of the effects of EE on the brain in a large animal model such as the pig. Twenty-four young pigs (aged 5 weeks at start of study, 1:1 male: female ratio) were housed in environmentally enriched (EE) pens and provided with additional enrichment stimulation (a bag filled with straw) once daily. Litter, weight and sex matched controls n= (24) were housed in barren (B) conditions...
May 17, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29778606/avatrombopag-before-procedures-reduces-need-for-platelet-transfusion-in-patients-with-chronic-liver-disease-and-thrombocytopenia
#20
Norah Terrault, Yi-Cheng Chen, Namiki Izumi, Zeid Kayali, Paul Mitrut, Won Young Tak, Lee F Allen, Tarek Hassanein
BACKGROUND & AIMS: Patients with thrombocytopenia and chronic liver disease (CLD) may require platelet transfusions before scheduled procedures to decrease risk of bleeding. We performed 2 randomized, placebo-controlled, phase 3 trials in patients with thrombocytopenia and CLD undergoing scheduled procedures to evaluate the safety and efficacy of avatrombopag in increasing platelet counts in this patient population METHODS: In the ADAPT-1 and ADAPT-2 studies, adults with thrombocytopenia and CLD (n=231 and n= 204, respectively) were in 1 of 2 cohorts according to their baseline platelet count (below 40x109 /L or 40-50x109 /L) and within each cohort randomized (2:1) to 5 daily doses of avatrombopag (60 mg if baseline platelet count below 40x109 /L or 40 mg if 40-50x109 /L) or placebo...
May 17, 2018: Gastroenterology
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