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https://www.readbyqxmd.com/read/29353357/heath-risk-among-pesticide-sellers-in-bamenda-cameroon-and-peripheral-areas
#1
Jean Sonchieu, Edouard Nantia Akono, Cheche Tanwi Ngwamitang, Benoït Martin Ngassoum
In Bamenda and peripheral zones, studies have been focused on the effects of pesticides on farmers (pesticide users) while nothing has been done to assess the exposure of sellers to pesticides. This study aimed at evaluating the exposure of pesticide sellers in the same area. Thirty-two questionnaires were administered to 32 pesticide sellers systematically selected, and chi-square was used for statistical analysis. From each shop, a respondent was chosen among the workers according to its daily time spent in the workplace...
January 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29353349/daclatasvir-a-review-of-preclinical-and-clinical-pharmacokinetics
#2
REVIEW
Yash Gandhi, Timothy Eley, Aberra Fura, Wenying Li, Richard J Bertz, Tushar Garimella
Daclatasvir is a first-in-class, highly selective, hepatitis C virus, non-structural protein 5a polymerase replication complex inhibitor with picomolar potency and broad genotypic coverage in vitro. Daclatasvir undergoes rapid absorption, with a time to reach maximum plasma concentration of 1-2 h and an elimination half-life of ~ 10 to 14 h observed in single-ascending dose studies. Steady state was achieved by day 4 in multiple-ascending dose studies. Daclatasvir can be administered without regard to food or pH modifiers...
January 20, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29353315/whole-grain-intakes-in-irish-adults-findings-from-the-national-adults-nutrition-survey-nans
#3
Clare B O'Donovan, Niamh F Devlin, Maria Buffini, Janette Walton, Albert Flynn, Michael J Gibney, Anne P Nugent, Breige A McNulty
PURPOSE: Observational studies link high whole grain intakes to reduced risk of many chronic diseases. This study quantified whole grain intakes in the Irish adult population and examined the major contributing sources. It also investigated potential dietary strategies to improve whole grain intakes. METHODS: Whole grain intakes were calculated in a nationally representative sample of 1500 Irish adults using data from the most recent national food survey, the National Adult Nutrition Survey (NANS)...
January 20, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29353262/preterm-human-milk-macronutrient-concentration-is-independent-of-gestational-age-at-birth
#4
Jan Maly, Iva Burianova, Veronika Vitkova, Eva Ticha, Martina Navratilova, Eva Cermakova
OBJECTIVE: To evaluate the amount of macronutrients in aggregate of human milk samples after preterm delivery during the first 2 months of lactation. METHODS: Analysis of the donated single milk samples, gained by complete emptying of the whole breast at the same daytime between 24+0 and 35+6 gestational age (GA), was designed as prospective observational cohort trial. Two milk samples were analysed every postnatal week up to the discharge from the hospital, week 9 or loss of lactation...
January 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29353243/impact-of-order-set-design-on-urine-culturing-practices-at-an-academic-medical-centre-emergency-department
#5
Satish Munigala, Ronald R Jackups, Robert F Poirier, Stephen Y Liang, Helen Wood, S Reza Jafarzadeh, David K Warren
BACKGROUND: Urinalysis and urine culture are commonly ordered tests in the emergency department (ED). We evaluated the impact of removal of order sets from the 'frequently ordered test' in the computerised physician order entry system (CPOE) on urine testing practices. METHODS: We conducted a before (1 September to 20 October 2015) and after (21 October to 30 November 2015) study of ED patients. The intervention consisted of retaining 'urinalysis with reflex to microscopy' as the only urine test in a highly accessible list of frequently ordered tests in the CPOE system...
January 20, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29353159/trauma-attentional-dysregulation-and-the-development-of-posttraumatic-stress-an-investigation-of-risk-pathways
#6
Judith Schäfer, Ariel Zvielli, Michael Höfler, Hans-Ulrich Wittchen, Amit Bernstein
BACKGROUND: Fundamental questions regarding the nature and function of attentional bias (AB) to threat in the etiology of posttraumatic stress disorder (PTSD) remain unanswered. We tested the temporal interplay between trauma exposure, dysregulated attentional processing of threatening information pre- and post-trauma, and the development of posttraumatic intrusions. METHODS: Response time to trauma-related threat, trauma-unrelated threat, as well as to trauma-related but typically emotionally-neutral stimuli was assessed using the dot probe task before and one week after watching a violent movie scene that served as a trauma analogue...
January 11, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29353117/exposure-keratopathy-incidence-risk-factors-and-impact-of-protocolised-care-on-exposure-keratopathy-in-critically-ill-adults
#7
Obaid Kousha, Zubaid Kousha, Jonathan Paddle
PURPOSE: We aimed to determine the rate of exposure keratopathy (EK) in critically ill patients, identify risk factors for developing EK and ascertain the effectiveness of a protocol to prevent EK. MATERIALS AND METHODS: We undertook a two-phase prospective cohort study in a general adult ICU with first-phase being observational and an eye care protocol was introduced in the second-phase. Daily ophthalmic assessment was carried out along with recording of various risk factors...
November 28, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29353091/adding-vibrotactile-feedback-to-a-myoelectric-controlled-hand-improves-performance-when-online-visual-feedback-is-disturbed
#8
Eitan Raveh, Sigal Portnoy, Jason Friedman
We investigated whether adding vibrotactile feedback to a myoelectric-controlled hand, when visual feedback is disturbed, can improve performance during a functional test. For this purpose, able-bodied subjects, activating a myoelectric-controlled hand attached to their right hand performed the modified Box & Blocks test, grasping and manipulating wooden blocks over a partition. This was performed in 3 conditions, using a repeated-measures design: in full light, in a dark room where visual feedback was disturbed and no auditory feedback - one time with the addition of tactile feedback provided during object grasping and manipulation, and one time without any tactile feedback...
January 17, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29353060/parathyroid-hormone-related-protein-contributes-to-early-healing-of-habu-snakevenom-induced-glomerulonephritis-in-mice
#9
Mazène Hochane, Denis Raison, Catherine Coquard, Claire Béraud, Sabrina Danilin, Audrey Bethry, Thierry Massfelder, Mariette Barthelmebs
Proliferative glomerulonephritis is characterized by local inflammation and mesangial cell deterioration, followed by mesangial proliferation and glomerular healing. Parathyroid-hormone-related peptide (PTHrP) is a mesangial cytokine-like growth factor implicated in mesangial proliferation and survival. No data are available about its role in glomerulonephritis. Herein, we analyzed the expression and role of PTHrP in glomerular inflammation and healing in an experimental model of glomerulonephritis induced by intravenous injection of Habu-snake venom in mice...
January 15, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29353054/the-role-of-the-vasopressin-v1a-receptor-in-oxytocin-modulation-of-methamphetamine-primed-reinstatement
#10
Nicholas A Everett, Iain S McGregor, Sarah J Baracz, Jennifer L Cornish
The neuropeptide oxytocin has shown promise as an effective therapy in pre-clinical models of methamphetamine (METH) addiction. The nucleus accumbens core (NAcc) has been identified as an important site for oxytocin to inhibit METH behaviours, although previous findings suggest that the effects of oxytocin in the NAcc are mediated by receptors other than the oxytocin receptor (OTR). Oxytocin has high affinity for the vasopressin V1A receptor (V1AR) which has been implicated in numerous oxytocin-dependent social behaviours...
January 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29353026/efficacy-and-safety-of-lebrikizumab-an-anti-il-13-monoclonal-antibody-in-adults-with-moderate-to-severe-atopic-dermatitis-inadequately-controlled-by-topical-corticosteroids-a-randomized-placebo-controlled-phase-ii-trial-treble
#11
Eric L Simpson, Carsten Flohr, Lawrence F Eichenfield, Thomas Bieber, Howard Sofen, Alain Taïeb, Ryan Owen, Wendy Putnam, Marcela Castro, Kendra DeBusk, Chin-Yu Lin, Athina Voulgari, Karl Yen, Theodore A Omachi
BACKGROUND: Interleukin (IL)-13 plays a key role in type 2 inflammation and is an emerging pathogenic mediator in atopic dermatitis. OBJECTIVE: We investigated the efficacy and safety of lebrikizumab, an anti-IL-13 monoclonal antibody, as add-on to topical corticosteroid (TCS). METHODS: A randomized, placebo-controlled, double-blind, phase II study. Adults with moderate-to-severe AD were required to use twice-daily TCS, and randomized (1:1:1:1) to lebrikizumab 125 mg single dose (SD), 250 mg SD, 125 mg once every 4 weeks (Q4W), or placebo Q4W for 12 weeks, after 2-week TCS run-in...
January 15, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29353021/phosphoproteomics-unveils-stable-energy-supply-as-key-to-flooding-tolerance-in-kandelia-candel
#12
Dezhuo Pan, Lingxia Wang, Fanglin Tan, Si Lu, Xiaojie Lv, Madiha Zaynab, Chi-Lien Cheng, Yakubu Saddeeq Abubakar, Shipin Chen, Wei Chen
The mangrove Kandelia candel (L.) Druce experiences daily flooding cycles. To explore the molecular mechanism underlying the physiological adaptation of K. candel to flooding, the potential role of protein phosphorylation in flooding responses was investigated by a large-scale quantitative phosphoproteomic analysis using isobaric tag for relative and absolute quantitation. Total 2141 unique phosphopeptides and 2603 non-redundant phosphorylation sites were identified from 1516 phosphoproteins in K. candel leaves...
January 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29352909/a-review-of-polysaccharides-from-schisandra-chinensis-and-schisandra-sphenanthera-properties-functions-and-applications
#13
REVIEW
Zijian Li, Xin He, Fei Liu, Jue Wang, Juan Feng
Schisandra is an herbal plant resource with dual functions in medicine and food since ancient times. It has a variety of healthcare and therapeutic effects. Schisandra chinensis (Turcz.) Baill and Schisandra sphenanthera Rehd. et Wits are two of the most commonly used Schisandra. Traditional Chinese medicine experience has shown that water-soluble polysaccharide from Schisandra may be one of its main components with pharmacological effects. Progress in the industrial production and extraction process of plant polysaccharides, especially Chinese medicine polysaccharides in the past three decades, have led to many new discoveries about Schisandra polysaccharides in the fields of purification and identification...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352837/socio-economic-determinants-of-vitamin-d-deficiency-in-the-older-polish-population-results-from-the-polsenior-study
#14
Magdalena Wyskida, Aleksander Owczarek, Aleksandra Szybalska, Aniceta Brzozowska, Irena Szczerbowska, Katarzyna Wieczorowska-Tobis, Monika Puzianowska-Kuźnicka, Edward Franek, Małgorzata Mossakowska, Tomasz Grodzicki, Andrzej Więcek, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek
OBJECTIVE: Numerous studies have reported an association between vitamin D (25-hydroxyvitamin D; 25(OH)D) deficiency and low economic status, lower educational level, drugs exposure, smoking and reduced physical activity. Our study analysed the association between sociodemographic factors and 25(OH)D status in Polish (Caucasian) seniors. DESIGN: Cross-sectional study (part of the PolSenior study). Serum 25(OH)D concentration was measured by a solid-phase ELISA method; a standardized questionnaire evaluated educational level, economic status, alcohol consumption, current or past cigarette smoking, physical activity, activities of daily living (ADL) and instrumental activities of daily living...
January 21, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29352829/the-who-recommendation-of-home-fortification-of-foods-with-multiple-micronutrient-powders-in-children-under-2-years-of-age-and-its-effectiveness-on-anaemia-and-weight-a-pragmatic-cluster-randomized-controlled-trial
#15
Yassinmè Elysée Somassè, Michèle Dramaix, Boncana Traoré, Ildephonse Ngabonziza, Ousmane Touré, Mamadou Konaté, Mamadou Diallo, Philippe Donnen
OBJECTIVE: To assess under real community settings the effectiveness of the WHO strategy of home fortification of foods (HFF) with multiple-micronutrient powders on Hb change, anaemia and weight in children. DESIGN: A pragmatic cluster-randomized controlled trial. SETTING: Forty villages in the Nioro Circle in Mali and 722 children aged 6-23 months were randomized to the intervention or control group. The intervention consisted of a daily dose of multiple-micronutrient powder for 3 months; in the control group, no supplement was given...
January 21, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29352828/sensitivity-of-fatty-acid-desaturation-and-elongation-to-plasma-zinc-concentration-a-randomised-controlled-trial-in-beninese-children
#16
Tsitsi Chimhashu, Linda Malan, Jeannine Baumgartner, Paul J van Jaarsveld, Valeria Galetti, Diego Moretti, Cornelius M Smuts, Michael B Zimmermann
Zn status may affect fatty acid (FA) metabolism because it acts as a cofactor in FA desaturase and elongase enzymes. Zn supplementation affects the FA desaturases of Zn-deficient rats, but whether this occurs in humans is unclear. We evaluated the associations between baseline plasma Zn (PZn) concentration and plasma total phospholipid FA composition, as well as the effect of daily consumption of Zn-fortified water on FA status in Beninese children. A 20-week, double-blind randomised controlled trial was conducted in 186 school age children...
January 21, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29352738/persistent-pain-following-common-outpatient-surgeries-in-children-a-multicenter-study-in-italy
#17
Valeria Mossetti, Karen Boretsky, Marinella Astuto, Bruno G Locatelli, David Zurakowski, Rodolfo Lio, Roberta Nicoletti, Valter Sonzogni, Micol Maffioletti, Noemi Vicchio, Giorgio Ivani
INTRODUCTION: The prevalence of persistent postsurgical pain in children is over 20% after major surgeries; however, data are scarce on the prevalence, character, and risk factors among children undergoing common ambulatory surgeries. The primary aim of this study was to evaluate the prevalence of persistent pain following pediatric ambulatory surgery at 1, 3, and 6 months. Secondary aims were to identify risk factors and characterize the pain and consequences of persistent postsurgical pain...
January 20, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29352732/long-term-effects-of-crizotinib-in-alk-positive-tumors-excluding-nsclc-a-phase-1b-open-label-study
#18
Carlo Gambacorti-Passerini, Sergey Orlov, Li Zhang, Fadi Braiteh, Huiqiang Huang, Taito Esaki, Keizo Horibe, Jin-Seok Ahn, Joseph T Beck, William Jeffrey Edenfield, Yuankai Shi, Matthew Taylor, Kenji Tamura, Brian A Van Tine, Shang-Ju Wu, Jolanda Paolini, Paulina Selaru, Tae Min Kim
Crizotinib, an inhibitor of anaplastic lymphoma kinase (ALK), MET, and ROS1, is approved for treatment of patients with ALK-positive or ROS1-positive advanced non-small-cell lung cancer (NSCLC). However, ALK rearrangements are also implicated in other malignancies, including anaplastic large-cell lymphoma and inflammatory myofibroblastic tumors (IMTs). In this ongoing, multicenter, single-arm, open-label phase 1b study (PROFILE 1013; NCT01121588), patients with ALK-positive advanced malignancies other than NSCLC were to receive a starting dose of crizotinib 250 mg twice daily...
January 20, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29352722/daily-intake-of-mucuna-pruriens-in-advanced-parkinson-s-disease-a-16-week-noninferiority-randomized-crossover-pilot-study
#19
Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Benedetta Raspini, Michela Barichella, Gianni Pezzoli
BACKGROUND: Thousands of individuals with Parkinson's disease (PD) in low-income countries have limited access to marketed levodopa preparations. Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in tropical areas, may be a sustainable alternative therapy for indigent patients. Single-dose intake of MP proved noninferior to marketed levodopa preparations. METHODS: Fourteen PD patients with motor fluctuations and dyskinesias received MP powder (obtained from roasted seeds) and marketed levodopa/carbidopa (LD/CD) in a randomized order and crossover design over a 16-week period...
January 11, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29352714/effect-of-single-agent-daily-prednisone-on-outcomes-and-toxicities-in-metastatic-castration-resistant-prostate-cancer-pooled-analysis-of-prospective-studies
#20
REVIEW
Pooja Ghatalia, Gregory R Pond, Arnoud J Templeton, Guru Sonpavde
The clinical effect of prednisone in metastatic castration-resistant prostate cancer (mCRPC) is unknown. We performed a pooled analysis of control arms of randomized controlled trials that had or had not administered single-agent prednisone. Randomized controlled trials with a control arm that included single-agent placebo (or no anticancer therapy) or single-agent prednisone (with or without placebo) were eligible for analysis. Patients receiving prednisone combined with other agents in the control arm were excluded...
December 27, 2017: Clinical Genitourinary Cancer
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