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https://www.readbyqxmd.com/read/28743114/cervical-alpha-actinin-4-is-upregulated-in-women-with-threatened-preterm-labor-and-microbial-invasion-of-the-amniotic-cavity
#1
Teresa Cobo, Montse Palacio, Maribel Grande, Ana B Sánchez-García, Josep M Estanyol, Marta López, Jordi Bosch, Cristina Martí, Eduard Gratacós
OBJECTIVE: To characterize the proteome profile of women with threatened preterm labor (PTL) below 34;0 weeks with and without microbial invasion of the amniotic cavity (MIAC) using mass spectrometry in the amniotic fluid (AF) and Western blot analysis in the cervical mucus and the vaginal fluid. SUBJECTS AND METHODS: In the discovery phase, a case-control study including 8 women with MIAC and 7 without matched for gestational age at sampling was performed. Proteomic profile characterization was done using the LTQ VELOS Orbitrap mass spectrometer in the AF...
July 26, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28742955/bayesian-one-step-ipd-network-meta-analysis-of-time-to-event-data-using-royston-parmar-models
#2
Suzanne C Freeman, James R Carpenter
Network meta-analysis (NMA) combines direct and indirect evidence from trials to calculate and rank treatment estimates. While modelling approaches for continuous and binary outcomes are relatively well developed, less work has been done with time-to-event outcomes. Such outcomes are usually analysed using Cox proportional hazard (PH) models. However, in oncology with longer follow-up time, and time-dependent effects of targeted treatments, this may no longer be appropriate. Network meta-analysis conducted in the Bayesian setting has been increasing in popularity...
July 25, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/28742851/knowledge-attitude-and-practice-for-cervical-cancer-prevention-and-control-among-women-of-childbearing-age-in-hossana-town-hadiya-zone-southern-ethiopia-community-based-cross-sectional-study
#3
Yitagesu Habtu Aweke, Samuel Yohannes Ayanto, Tariku Laelago Ersado
BACKGROUND: Cervical cancer is the second most common female cancer which Ethiopia put a strategic goal to reduce its incidence and mortality by 2020. Lack of knowledge and poor attitude towards the disease and risk factors can affect screening practice and development of preventive behavior for cervical cancer. The aim of this study was to assess knowledge, attitude, practices and factors for each domain for cervical cancer among women of child bearing age in Hossana town, Southern, Ethiopia...
2017: PloS One
https://www.readbyqxmd.com/read/28742761/preparation-and-assessment-of-an-individualized-navigation-template-for-lower-cervical-anterior-transpedicular-screw-insertion-using-a-three-dimensional-printing-technique
#4
FengNing Li, Xuan Huang, Kun Wang, BeiEr Luo, Fan Zhang, Zhi Chen, Quan Li, YongJin Zhang, Ke Qi, ChengChun Jin, WangShenJie Chen, CangLong Hou, HongXing Shen
STUDY DESIGN: Prospective trial. OBJECTIVE: To establish an individualized navigation template for safe and accurate insertion of lower cervical anterior transpedicular screw (ATPS) based on a three-dimensional (3D) printing technique. SUMMARY OF BACKGROUND DATA: Conventional screw insertion manually under fluoroscopy easily leading to deviation of ATPS screw channel, cervical instrumentation procedures demand the need for a precise technique for screw placement...
July 24, 2017: Spine
https://www.readbyqxmd.com/read/28742760/a-randomized-trial-comparing-clinical-outcomes-between-zero-profile-and-traditional-multi-level-anterior-cervical-discectomy-and-fusion-surgery-for-cervical-myelopathy
#5
Shenghua He, Hualong Feng, Zhiming Lan, Lai Juyi, Zhitao Sun, Yeguang Wang, Jian Wang, Zhiqiang Ren, Feiqiang Huang, Fuguang Xu
STUDY DESIGN: Prospective randomized study from a single center OBJECTIVE.: The purpose of this study was to compare outcomes between a zero-profile (ZP) anterior cervical discectomy and fusion (ACDF) construct to a traditional ACDF with anterior plate (ACP) in the treatment of multilevel cervical spondylotic myelopathy. SUMMARY OF BACKGROUND DATA: Multi-level cervical spondylotic myelopathy can be treated by a variety of techniques, most commonly with corpectomy, ACDF, posterior cervical fusion or a combination of the three...
July 24, 2017: Spine
https://www.readbyqxmd.com/read/28742757/concurrent-validity-and-responsiveness-of-promis-health-domains-among-patients-presenting-for-anterior-cervical-spine-surgery
#6
Taylor E Purvis, Elena Andreou, Brian J Neuman, Lee H Riley, Richard L Skolasky
STUDY DESIGN: Prospective cohort study. OBJECTIVE: To determine validity and responsiveness of Patient-Reported Outcomes Measurement Information System (PROMIS) health domains. SUMMARY OF BACKGROUND DATA: PROMIS health domains (anxiety, depression, fatigue, pain, physical function, satisfaction with participation in social roles, sleep disturbance) may measure quality of care and determine minimal important differences (MIDs) after spine surgery...
July 24, 2017: Spine
https://www.readbyqxmd.com/read/28742697/are-thoracotomy-and-or-intrathoracic-anastomosis-still-predictors-of-postoperative-mortality-after-esophageal-cancer-surgery-a-nationwide-study
#7
Sébastien Degisors, Arnaud Pasquer, Florence Renaud, Hélène Béhal, Flora Hec, Anne Gandon, Marguerite Vanderbeken, Gilbert Caranhac, Alain Duhamel, Guillaume Piessen, Christophe Mariette
BACKGROUND: Intrathoracic (vs cervical) anastomosis and a thoracotomy (vs absence) have previously been associated with increasing postoperative mortality (POM). Recent improvements in surgical practices and perioperative management may have changed these dogmas. OBJECTIVES: The aim of this study was to evaluate the impact of performing intrathoracic anastomosis and/or thoracotomy on POM after esophageal cancer surgery in recent years. METHODS: All consecutive patients who underwent esophageal cancer surgery with reconstruction between 2010 and 2012 in France were included (n = 3286)...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742594/cervical-evaluation-in-pregnancy-proper-measurement-evaluation-and-management
#8
Joseph R Wax, Angelina Cartin, Michael G Pinette
Preterm birth is the leading cause of perinatal morbidity and mortality in developed nations. The heterogeneous causes of spontaneous preterm birth make prediction and prevention difficult. The primary importance of transvaginal cervical sonography and cervicovaginal fetal fibronectin lies in their high negative predictive values in assessing risk for preterm birth. Cervical length may be useful in identifying women who are candidates for cervical cerclage or progesterone therapy for preterm birth prevention...
September 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742592/pregnancy-in-an-abnormal-location
#9
Ana Monteagudo, Julie A Romero, Ilan E Timor-Tritsch
Cesarean scar pregnancy and cervical pregnancy are 2 relatively rare types of abnormally implanted pregnancies. Both if unrecognized can result in significant morbidity to the patient. The most important issue regarding cesarean scar pregnancy and cervical pregnancy is to establish the diagnosis early in order for the patient to be adequately counseled and appropriate management carried out. For both of these conditions early detection and treatment can result in preservation of fertility.
September 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742428/neck-and-upper-limb-dysfunction-in-patients-following-neck-dissection-looking-beyond-the-shoulder
#10
Elise M Gane, Shaun P O'Leary, Anna L Hatton, Benedict J Panizza, Steven M McPhail
Objective To measure patient-perceived upper limb and neck function following neck dissection and to investigate potential associations between clinical factors, symptoms, and function. Study Design Cross-sectional. Setting Two tertiary hospitals in Brisbane, Australia. Subjects and Methods Inclusion criteria: patients treated with neck dissection (2009-2014). EXCLUSION CRITERIA: aged <18 years, accessory nerve or sternocleidomastoid sacrifice, previous neck dissection, preexisting shoulder/neck injury, and inability to provide informed consent (cognition, insufficient English)...
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28742241/cervical-epidural-injection-in-management-of-refractory-pain-and-stiffness-in-spondyloarthropathy-a-case-report-series
#11
Semih Gungor, Rohit Aiyer, Doruk Erkan
In this case report series, we present the management of three patients with cervical epidural steroid injection, who presented with neck pain and stiffness secondary to spondyloarthropathy refractory to conservative management. This article is protected by copyright. All rights reserved.
July 25, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28742203/expression-levels-and-roles-of-emc-6-beclin1-and-rab5a-in-the-cervical-cancer
#12
M-X Shen, J-B Ding
OBJECTIVE: This study is to investigate the role of EMC-6 in the pathogenesis of cervical cancer, especially concerning its relationship with autophagy. PATIENTS AND METHODS: Totally 100 invasive cervical cancer, 80 cervical intraepithelial neoplasia (CIN), and 80 normal cervical tissue samples were obtained. Expression levels of EMC-6, Beclin1, and Rab5a in the tissues were detected by immunohistochemistry. RESULTS: Our results showed that positive staining of EMC-6 was mainly located in the nucleus...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28742156/ct-pattern-analysis-of-necrotizing-and-nonnecrotizing-lymph-nodes-in-kikuchi-disease
#13
Eun Jung Shim, Kyung Mi Lee, Eui Jong Kim, Hyug-Gi Kim, Ji Hye Jang
OBJECTIVE: The purpose of this study was to determine whether a CT interpretation with imaging pattern analysis differentiates Kikuchi disease (KD) from the two more frequently encountered differential lymph nodes diagnoses of tuberculous lymphadenopathy (TL) and reactive hyperplasia (RH). MATERIALS AND METHODS: Between January 2012 and July 2015, 20 patients with KD (6 men, 14 women; mean age, 27.80 years), 36 patients with RH (10 men, 26 women; mean age, 33.08 years) and 34 patients with TL (17 men, 17 women; mean age, 39...
2017: PloS One
https://www.readbyqxmd.com/read/28741742/dental-and-skeletal-maturation-in-female-adolescents-with-temporomandibular-joint-osteoarthritis
#14
Jeong-Hyun Kang, Ill-Hyung Yang, Hong-Keun Hyun, Jeong-Yun Lee
BACKGROUND: Occurrence of temporomandibular disorders (TMDs) and temporomandibular joint (TMJ) osteoarthritis (OA) during adolescence may have interactions with mandibular and dental development. OBJECTIVE: To investigate relationships between occurrence of TMD and TMJ OA and extents of dental and skeletal development in juvenile female patients. METHOD: In total, 95 female adolescents (age range, 11-15 years) were selected. Among them, 15 subjects (control) had no signs of TMD, 39 TMD patients did not have OA (TMDnoOA), 17 TMD patients were at initial stage of TMJ OA (TMJOA), and 27 patients showed progressive stage of TMJ OA (TMJOA)...
July 25, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28741286/interleukin-6-receptor-il-6r-was-an-independent-prognostic-factor-in-cervical-cancer
#15
Shaohong Luan, Zhijie An, Shuna Bi, Long Chen, Jun Fan
IL-6 has been found to be associated with poor response to chemoradiotherapy and poor overall prognosis of patients with cervical cancer. However, little is known about the clinicopathological significance of IL-6 receptor (IL-6R) expression in the setting of cervical cancer. To investigate the clinicopathological meaning of IL-6R in cervical cancer, expression of IL-6R was detected using immunohistochemistry in cervical cancer tissue microarray composed of 98 cases of cervical cancer and paired normal controls...
July 25, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28741147/constipation-in-degenerative-cervico-thoracic-spine-myelopathy-a-simple-co-existence-or-a-complex-inter-relationship
#16
Anant Mehrotra, Janmejay Jamdar, Pradeep Sharma, Chaitanya Godbole, Suyash Singh, Kuntal Kanti Das, Abhai Verma, Kamlesh Singh Bhaisora, Jayesh Sardhara, Awadhesh Kumar Jaiswal, Rabi Narayan Sahu, Arun Kumar Srivastava, Sanjay Behari, Raj Kumar
PURPOSE: Identify factors affecting constipation and post surgical improvement in patients of myelopathy. METHODS: Sixty-four patients with myelopathy due to extradural spine pathologies (47 cervical; 17 thoracic spine, male:female-5.4:1 with mean age 46.16) underwent evaluation including Bristol stool scale (BSS), PFT and uroflowmetry. All cases were evaluated by gastroenterologist to rule out any intrinsic bowel disease. Chi-square test, Kruskal-Wallis/Mann-Whitney U test and Wilcoxon signed rank test were employed to ascertain statistical significance...
July 24, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28741042/the-first-case-of-lymphogranuloma-venereum-in-a-woman-in-east-central-europe-and-its-multiple-co-infections
#17
Katerina Juzlova, Filip Rob, Hana Zakoucka, Andrea Kubatova, Zuzana Secnikova, Martina Krasova, Petr Bohac, Jana Hercogova
We are reporting the first case of lymphogranuloma venereum in women in East-Central Europe. A 22-year-old heterosexual woman attended our department of venereology. She complained about a burning sensation in the urethra and vaginal discharge. Many tests were performed, and lymphogranuloma venereum, syphilis, gonorrhea, chlamydial urethritis and cervicitis, genital herpes, genital warts, and hepatitis C were diagnosed. Lymphogranuloma venereum was originally endemic in tropical and subtropical areas, but since 2003, outbreaks of this infection have been reported in North America, Europe, and Australia in men who have sex with men (MSM) community...
July 24, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28740747/in-vitro-assessment-of-anti-proliferative-effect-induced-by-%C3%AE-mangostin-from-cratoxylum-arborescens-on-hela-cells
#18
Aisha I El Habbash, Najihah Mohd Hashim, Mohamed Yousif Ibrahim, Maizatulakmal Yahayu, Fatima Abd Elmutaal Omer, Mashitoh Abd Rahman, Noraziah Nordin, Gwendoline Ee Cheng Lian
Natural medicinal products possess diverse chemical structures and have been an essential source for drug discovery. Therefore, in this study, α-mangostin (AM) is a plant-derived compound was investigated for the apoptotic effect on human cervical cancer cells (HeLa). The cytotoxic effects of AM on the viability of HeLa and human normal ovarian cell line (SV40) were evaluated by using MTT assay. Results showed that AM inhibited HeLa cells viability at concentration- and time-dependent manner with IC50 value of 24...
2017: PeerJ
https://www.readbyqxmd.com/read/28740536/loca-lopa-myelopathy-is-prevention-better-than-cure
#19
Kamal Kishore Pandita, Sushil Razdan, Sarla Pandita
Manifestations of primary hypoparathyroidism are produced by neuromuscular irritability or by extraosseous calcifications. We present a patient of primary hypoparathyroidism who had extensive calcification of brain parenchyma, and was suffering from chronic, generalised and progressive stiffness of body due to cervical compressive myelopathy, caused by calcification of posterior longitudinal ligament and ligamentum flavum. By presenting this case we wanted to emphasize the usefulness of meticulous clinical examination to differentiate the stiffness caused by myelopathy from that which is caused by possible coexisting extrapyramidal disorder...
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28740435/barriers-and-facilitators-to-cervical-cancer-screening-among-pakistani-and-somali-immigrant-women-in-oslo-a-qualitative-study
#20
Abdi A Gele, Samera A Qureshi, Prabhjot Kour, Bernadette Kumar, Esperanza Diaz
Norway has a low incidence and mortality rate of cervical cancer, which is mainly due to the high participation rate of women in cervical cancer screening. However, the attendance of cervical cancer screening was reported to be low among immigrant women. For this reason, we conducted a qualitative study to obtain better insight into perceived barriers and challenges to cervical cancer screening among Somali and Pakistani women in the Oslo region. A convenient sample of 35 (18 Pakistani, 17 Somali) women were recruited for the study in collaboration with Somali and Pakistani community partners...
2017: International Journal of Women's Health
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