keyword
https://read.qxmd.com/read/37735856/comparison-of-serum-anti-m%C3%A3-llerian-hormone-between-unilateral-and-bilateral-ovarian-endometriomas-during-follicular-luteal-and-random-menstrual-phases-a-retrospective-study
#1
JOURNAL ARTICLE
Juhun Lee, Jong Mi Kim, Gun Oh Chong, Dae Gy Hong, Yoon Hee Lee
BACKGROUND: Over the last two decades, serum levels of anti-Müllerian hormone (AMH) have been shown to be reliable markers of ovarian reserve. This study aimed to compare baseline serum AMH levels and well-controlled clinical factors between patients with unilateral and bilateral ovarian endometriomas during the menstrual phase. METHODS: We conducted a retrospective study. We enrolled 136 patients aged 18 to 36 years who were diagnosed with unilateral or bilateral ovarian endometriomas...
September 22, 2023: J Yeungnam Med Sci
https://read.qxmd.com/read/37453692/sexually-dimorphic-expression-of-amh-facilitates-testis-differentiation-pathway-in-the-tropical-lizard-calotes-versicolor-daud
#2
JOURNAL ARTICLE
Rahul M Handi, Laxmi S Inamdar Doddamani
The Anti-mullerian hormone (AMH), also known as Mullerian inhibiting substance (MIS), is a glycoprotein that belongs to transforming growth factor β superfamily. The significance of AMH during gonadal differentiation is not clearly deciphered in reptiles. Hence, current study aims to know the onset of AMH secretion and its functional role in Mullerian duct regression gonadal differentiation in tropical lizard, Calotes versicolor which exhibits a. novel Female-Male-Female-Male (FMFM) pattern of temperature-dependent sex determination (TSD)...
July 13, 2023: Molecular and Cellular Endocrinology
https://read.qxmd.com/read/36923385/persistent-mullerian-duct-syndrome-with-polycystic-ovary-in-a-young-adult-a-rare-case-report
#3
Zuhal Y Hamd, Muthab A Mohammed Ali, Amal I Alorainy, Awadia Gareeballah, Anas Hamdoun, E Manssor, Basim Abdullah Alhomida
Persistent Mullerian Duct Syndrome (PMDS) is a type of pseudohermaphroditism that occurs in males. It is an autosomal recessive type of familial disease that is commonly associated with a history of consanguinity. We have documented this case of a 22-year-old adult male who came with acute right iliac pain; after an ultrasound scan and hormone investigations, he was diagnosed with polycystic ovarian syndrome (PCOS).
May 2023: Radiology Case Reports
https://read.qxmd.com/read/36495634/anti-m%C3%A3-llerian-hormone-in-queens-serum-concentrations-and-total-ovarian-follicle-population
#4
JOURNAL ARTICLE
C Lapuente, M Faya, P G Blanco, M Grisolia-Romero, C Marchetti, C Gobello
The objectives of this study were: a) To report anti-Müllerian hormone (AMH) serum concentrations in neonatal, pre and postpubertal female cats. b) To establish the relationship between serum AMH with either age and estrous cycle c) To correlate the total number of different ovarian follicle types with AMH in adult queens. A single blood sample was collected from 10 neonates (including 5 male), 15 prepubertal and 48 postpubertal female cats to measure AMH. Eight, 10, and 18 of this latter group were in follicular (FP), luteal phase (LP), and anestrus (AN), respectively...
November 24, 2022: Theriogenology
https://read.qxmd.com/read/36289767/anti-m%C3%A3-llerian-hormone-and-polycystic-ovary-syndrome-in-women-and-its-male-equivalent
#5
REVIEW
Nathalie di Clemente, Chrystèle Racine, Rodolfo A Rey
This article reviews the main findings on anti-Müllerian hormone (AMH) and its involvement in the pathogenesis of polycystic ovary syndrome (PCOS) and its male equivalent. In women, AMH is produced by granulosa cells from the mid-fetal life to menopause and is a reliable indirect marker of ovarian reserve. AMH protects follicles from atresia, inhibits their differentiation in the ovary, and stimulates gonadotrophin-releasing hormone neurons pulsatility. AMH overexpression in women with PCOS likely contributes to the increase of the follicle cohort and of androgen levels, leading to follicular arrest and anovulation...
October 7, 2022: Biomedicines
https://read.qxmd.com/read/36229588/breast-cancer-risk-coordinators-artificial-intelligence-based-density-measurement-and-mullerian-inhibiting-substance
#6
JOURNAL ARTICLE
Şevki Pedük, Sevcan Sarıkaya, Mustafa Tekin
BACKGROUND: Due to its increasing prevalence, breast cancer has become a serious public health problem. In addition to the models used to identify individuals at risk, the search for fast and accurate tools has continued for years. AIMS: In our study, we aimed to examine the correlation of mammographic density measurement and serum Mullerian-inhibiting substance (MIS) levels with an effective model such as Gail. METHODS: Of the women whose serum MIS levels were measured in the last 1 year, 214 participants who applied for routine breast examination were included in the study...
October 13, 2022: Irish Journal of Medical Science
https://read.qxmd.com/read/36186422/y-specific-amh-allele-amhy-is-the-master-sex-determining-gene-in-japanese-flounder-paralichthys-olivaceus
#7
JOURNAL ARTICLE
Ricardo Shohei Hattori, Keiichiro Kumazawa, Masatoshi Nakamoto, Yuki Nakano, Toshiya Yamaguchi, Takeshi Kitano, Eiichi Yamamoto, Kanako Fuji, Takashi Sakamoto
Japanese flounder ( Paralichthys olivaceus ) is an important marine fish species of both fisheries and aquaculture in Northeast Asia. The commercial interest for all-female progenies due to several sex-related traits has prompted basic research on the mechanisms of sex determination in this species. By conducting a linkage analysis of the sex-determining locus, we initially identified 12 microsatellite markers linked to sex in 11 scaffolds, whose localization was restricted to a specific region of linkage group 9...
2022: Frontiers in Genetics
https://read.qxmd.com/read/35916268/markers-of-ovarian-reserve-in-women-living-with-hiv-a-systematic-review
#8
REVIEW
Elizabeth M King, Shayda A Swann, Melanie C M Murray
BACKGROUND: Anti-Mullerian hormone (AMH) levels indicate ovarian reserve and are predictive of reproductive aging. Studies evaluating AMH levels in women with HIV have produced conflicting results, and reasons for inter-study differences have not been assessed. To understand reproductive aging in HIV, we conducted a systematic review of ovarian reserve among women with HIV. METHODS: We searched Ovid MEDLINE, Ovid EMBASE, and CAB Direct for studies including AMH in reproductive-aged women with HIV...
August 2, 2022: HIV Medicine
https://read.qxmd.com/read/35914480/lessons-learned-from-five-patients-of-persistent-mullerian-duct-syndrome-a-case-series
#9
JOURNAL ARTICLE
Shehryar Ahmed Khan Niazi, Muhammad Umer Mukhtar, Rameez Hassan, Qasim Mehmood
INTRODUCTION: Persistent Mullerian duct syndrome (PMDS) is a genetic disorder characterized by the persistence of Mullerian structures of fallopian tubes, uterus, and upper two-thirds of the vagina in a normal XY male. It is a rare genetic disorder that has been reported less than two hundred times. More rarely it may be seen in association with transverse testicular ectopia (TTE). PRESENTATION OF CASES: Four patients presented with swelling in the inguinal region and undescended testes...
July 27, 2022: International Journal of Surgery Case Reports
https://read.qxmd.com/read/35845134/human-umbilical-cord-mesenchymal-stem-cell-derived-extracellular-vesicles-carrying-microrna-29a-improves-ovarian-function-of-mice-with-primary-ovarian-insufficiency-by-targeting-hmg-box-transcription-factor-wnt-%C3%AE-catenin-signaling
#10
JOURNAL ARTICLE
Tian Gao, Yi Cao, Min Hu, Ying Du
Background: Primary ovarian insufficiency (POI) is a female disease characterized by ovarian function loss under 40 years old. Transplantation of exosomes is an encouraging regenerative medicine method that has the potential for restoring ovarian functions post-POI with high efficiency. Therefore, we investigate the therapeutic efficacy and potential mechanisms of human umbilical cord mesenchymal stem cell- (UCMSC-) derived exosomes on ovarian dysfunction post-POI. Methods: The model of POI was established by intraperitoneal injection with 5 mg/kg cisplatin...
2022: Disease Markers
https://read.qxmd.com/read/35380904/a-screen-of-repurposed-drugs-identifies-amhr2-misr2-agonists-as-potential-contraceptives
#11
JOURNAL ARTICLE
Yi Li, Lina Wei, Marie-Charlotte Meinsohn, Rana Suliman, Maeva Chauvin, Jim Berstler, Kate Hartland, Mark M Jensen, Natalie A Sicher, Nicholas Nagykery, Patricia K Donahoe, David Pepin
SignificanceThis study aims to identify drugs that activate the Mullerian inhibiting substance pathway to be used for contraception or other applications in women's health. We describe a high-throughput screening pipeline to identify small molecules that activate the Mullerian inhibiting substance type 2 receptor (MISR2) and validate their activity in bioassays. We identify five compounds from a repurposed drug library that specifically induce MISR2 signaling, trigger regression of the Mullerian duct, and inhibit follicle activation...
April 12, 2022: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/34900642/persistent-mullerian-duct-syndrome-a-rare-case-of-an-adult-infertile-male-with-bilateral-cryptorchidism
#12
Prakash Sankapal, Venkat Arjun Gite, Mayank Agrawal, Mahesh Sane, Atul Singal
Background: Persistent mullerian duct syndrome (PMDS) is a very rare form of internal male pseudohermaphroditism in individuals who are phenotypically males with 46 XY karyotypes harboring internal female reproductive organs which are Mullerian derivatives. It occurs as a defect in the genes coding for the Mullerian inhibiting substance (MIS) or the anti Mullerian hormone (AMH) receptor, ultimately leading to failure of regression of Mullerian ducts. Case Presentation: A 29-year-old male with PMDS presented with complaints of primary infertility...
July 2021: Journal of Reproduction & Infertility
https://read.qxmd.com/read/34539902/functional-profiles-of-m%C3%A3-llerian-inhibiting-substance-anti-m%C3%A3-llerian-hormone-mis-amh-in-primarily-cultured-endometrial-cancer-cells
#13
JOURNAL ARTICLE
Sang Il Kim, Joo Hee Yoon, Soo Young Hur
Background: Müllerian inhibiting substance/anti-Müllerian hormone (MIS/AMH) inhibits proliferation of MIS/AMH receptor-expressing gynecologic tumors in vivo and in vitro, but the underlying mechanisms have not been fully defined. This study aimed to investigate the expression of MIS/AMH type II receptor (MIS/AMHRII) in endometrial cancer, to identify the mechanism of growth inhibition in MIS/AMH-treated endometrial cancer cells, and to evaluate the clinical significance of MIS/AMH as an effective targeted therapy for MIS/AMH receptor-expressing tumors...
2021: Journal of Cancer
https://read.qxmd.com/read/34539570/variation-in-the-measurement-of-anti-m%C3%A3-llerian-hormone-what-are-the-laboratory-issues
#14
REVIEW
Rivak Punchoo, Sachin Bhoora
Anti-Müllerian Hormone (AMH) is a 140 kDa homodimeric glycoprotein consisting of two identical subunits linked by disulphide bonds and is synthesised by the testes and ovaries. Its clinical applications are prediction of ovarian response and gonadotropin dose selection upon in vitro fertilization. In males, AMH is used to investigate sexual developmental disorders and gonadal function. AMH is commonly assayed by enzyme-linked immunosorbent assay or automated immunoassay formats that show variation between methods...
2021: Frontiers in Endocrinology
https://read.qxmd.com/read/34315024/urinary-biomarkers-of-exposure-to-drinking-water-disinfection-byproducts-and-ovarian-reserve-a-cross-sectional-study-in-china
#15
JOURNAL ARTICLE
Yan-Ling Deng, Qiong Luo, Chong Liu, Jia-Yue Zeng, Ting-Ting Lu, Tian Shi, Fei-Peng Cui, Xiao-Qiong Yuan, Yu Miao, Min Zhang, Pan-Pan Chen, Yu-Feng Li, Wen-Qing Lu, Qiang Zeng
Experimental studies have demonstrated that disinfection byproducts (DBPs) can cause ovarian toxicity including inhibition of antral follicle growth and disruption of steroidogenesis, but there is a paucity of human evidence. We aimed to investigate whether urinary biomarkers of exposure to drinking water DBPs were associated with ovarian reserve. The present study included 956 women attending an infertility clinic in Wuhan, China from December 2018 to January 2020. Antral follicle count (AFC), ovarian volume (OV), anti-Mullerian hormone (AMH), and follicle-stimulating hormone (FSH) were measured as indicators of ovarian reserve...
July 21, 2021: Journal of Hazardous Materials
https://read.qxmd.com/read/34155118/structure-of-amh-bound-to-amhr2-provides-insight-into-a-unique-signaling-pair-in-the-tgf-%C3%AE-family
#16
JOURNAL ARTICLE
Kaitlin N Hart, William A Stocker, Nicholas G Nagykery, Kelly L Walton, Craig A Harrison, Patricia K Donahoe, David Pépin, Thomas B Thompson
Anti-Müllerian hormone (AMH), or Müllerian-inhibiting substance, is a protein hormone that promotes Müllerian duct regression during male fetal sexual differentiation and regulation of folliculogenesis in women. AMH is a member of the transforming growth factor beta (TGF-β) family, which has evolved to signal through its own dedicated type II receptor, AMH receptor type II (AMHR2). Structures of other TGF-β family members have revealed how ligands infer specificity for their cognate receptors; however, it is unknown how AMH binds AMHR2 at the molecular level...
June 29, 2021: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/34013359/anti-m%C3%A3-llerian-hormone-concentration-regulates-activin-receptor-like-kinase-2-3-expression-levels-with-opposing-effects-on-ovarian-cancer-cell-survival
#17
JOURNAL ARTICLE
Maëva Chauvin, Véronique Garambois, Sylvie Choblet, Pierre-Emmanuel Colombo, Myriam Chentouf, Laurent Gros, David-Paul De Brauwere, Martine Duonor-Cerutti, Karen Dumas, Bruno Robert, Marta Jarlier, Pierre Martineau, Isabelle Navarro-Teulon, David Pépin, Thierry Chardès, André Pèlegrin
Anti‑Müllerian hormone (AMH) type II receptor (AMHRII) and the AMH/AMHRII signaling pathway are potential therapeutic targets in ovarian carcinoma. Conversely, the role of the three AMH type I receptors (AMHRIs), namely activin receptor‑like kinase (ALK)2, ALK3 and ALK6, in ovarian cancer remains to be clarified. To determine the respective roles of these three AMHRIs, the present study used four ovarian cancer cell lines (COV434‑AMHRII, SKOV3‑AMHRII, OVCAR8, KGN) and primary cells isolated from tumor ascites from patients with ovarian cancer...
July 2021: International Journal of Oncology
https://read.qxmd.com/read/33980714/single-cell-sequencing-reveals-suppressive-transcriptional-programs-regulated-by-mis-amh-in-neonatal-ovaries
#18
JOURNAL ARTICLE
Marie-Charlotte Meinsohn, Hatice D Saatcioglu, Lina Wei, Yi Li, Heiko Horn, Maeva Chauvin, Motohiro Kano, Ngoc Minh Phuong Nguyen, Nicholas Nagykery, Aki Kashiwagi, Wesley R Samore, Dan Wang, Esther Oliva, Guangping Gao, Mary E Morris, Patricia K Donahoe, David Pépin
Müllerian inhibiting substance (MIS/AMH), produced by granulosa cells of growing follicles, is an important regulator of folliculogenesis and follicle development. Treatment with exogenous MIS in mice suppresses follicle development and prevents ovulation. To investigate the mechanisms by which MIS inhibits follicle development, we performed single-cell RNA sequencing of whole neonatal ovaries treated with MIS at birth and analyzed at postnatal day 6, coinciding with the first wave of follicle growth. We identified distinct transcriptional signatures associated with MIS responses in the ovarian cell types...
May 18, 2021: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/33851994/anti-m%C3%A3-llerian-hormone-in-female-reproduction
#19
REVIEW
Nathalie di Clemente, Chrystèle Racine, Alice Pierre, Joëlle Taieb
Anti-Müllerian hormone (AMH), also called Müllerian inhibiting substance, was shown to be synthesized by the ovary in the 1980s. This article reviews the main findings of the past 20 years on the regulation of the expression of AMH and its specific receptor AMHR2 by granulosa cells, the mechanism of action of AMH, the different roles it plays in the reproductive organs, its clinical utility, and its involvement in the principal pathological conditions affecting women. The findings in respect of regulation tell us that AMH and AMHR2 expression is mainly regulated by bone morphogenetic proteins, gonadotropins, and estrogens...
November 16, 2021: Endocrine Reviews
https://read.qxmd.com/read/33133021/transcriptional-regulation-of-m%C3%A3-llerian-inhibiting-substance-mis-and-establishment-of-a-gonadal-somatic-cell-line-using-mis-gfp-transgenic-medaka-oryzias-latipes
#20
JOURNAL ARTICLE
Toshiaki Kawabe, Hiroyuki Kariya, Seiji Hara, Tsuyoshi Shirozu, Eri Shiraishi, Koki Mukai, Takashi Yazawa, Seiya Inoue, Takeshi Kitano
In vertebrate germ cell differentiation, gonadal somatic cells and germ cells are closely related. By analyzing this relationship, it has recently been reported in mammals that primordial germ cells (PGCs), induced from pluripotent stem cells and germline stem cells, can differentiate into functional gametes when co-cultured in vitro with fetal gonadal somatic cells. In some fish species, differentiation into functional sperm by reaggregation or co-culture of gonadal somatic cells and germ cells has also been reported; however, the relationship between gonadal somatic cells and germ cells in these species is not well-understood...
2020: Frontiers in Endocrinology
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