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https://www.readbyqxmd.com/read/28222377/identification-of-autophagy-related-genes-lc3-and-atg4-from-yellow-catfish-pelteobagrus-fulvidraco-and-their-transcriptional-responses-to-waterborne-and-dietborne-zinc-exposure
#1
Chuan-Chuan Wei, Zhi Luo, Yu-Feng Song, Ya-Xiong Pan, Kun Wu, Wen-Jing You
Autophagy mediates the regulation of lipid metabolism. Moreover, our recent study indicated that waterborne and dietborne zinc (Zn) exposure differentially influenced lipid metabolism in a fish species of significance for aquaculture, yellow catfish Pelteobagrus fulvidraco, but further mechanism remained unknown. The hypothesis of the present study is that autophagy mediated the Zn-induced changes of lipid metabolism of yellow catfish subjected to different exposure pathways. To this end, we cloned key genes involved in autophagy in yellow catfish, explored their mRNA expressions in responses to different Zn exposure pathways...
February 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28222184/ecological-and-human-health-risks-associated-with-abandoned-gold-mine-tailings-contaminated-soil
#2
Veronica Mpode Ngole-Jeme, Peter Fantke
Gold mining is a major source of metal and metalloid emissions into the environment. Studies were carried out in Krugersdorp, South Africa, to evaluate the ecological and human health risks associated with exposure to metals and metalloids in mine tailings contaminated soils. Concentrations of arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), lead (Pb), manganese (Mn), nickel (Ni), and zinc (Zn) in soil samples from the area varied with the highest contamination factors (expressed as ratio of metal or metalloid concentration in the tailings contaminated soil to that of the control site) observed for As (3...
2017: PloS One
https://www.readbyqxmd.com/read/28222110/different-antibiotic-growth-promoters-induce-specific-changes-in-the-cecal-microbiota-membership-of-broiler-chicken
#3
Marcio C Costa, Jose A Bessegatto, Amauri A Alfieri, J Scott Weese, João A B Filho, Alexandre Oba
Antimicrobials are sometimes given to food animals at low doses in order to promote faster growth. However, the mechanisms by which those drugs improve performance are not fully understood. This study aimed to investigate the impact of zinc bacitracin (55g/ton), enramycin (10g/ton); halquinol® (30g/ton); virginiamycin (16,5g/ton) and avilamycin (10g/ton) on the cecal microbiota of broiler chicken, compared to a control group. Six hundred and twenty four chicks (Cobb 500) arriving to an experimental unit were randomly assigned into each treatment with four repetitions per treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28220918/cadmium-complexes-bearing-me2-n-e-o-e-s-se-organochalcogenoalkoxides-and-their-zinc-and-mercury-analogues
#4
Alexandra Pop, Clément Bellini, Răzvan Şuteu, Vincent Dorcet, Thierry Roisnel, Jean-François Carpentier, Anca Silvestru, Yann Sarazin
Heteroleptic zinc and cadmium complexes of the type [{(Me2)N^E^O(R2)}M-Nu]n (M = Zn, Cd; E = S, Se; R = CH3, CF3; Nu = N(SiMe3)2, I, Cl; n = 1-2) were prepared by reacting the alcohol proteo-ligands {(Me2)N^E^O(R2)}H with [M(N(SiMe3)2)2] (M = Zn, Cd) or [XMN(SiMe3)2] (M = Zn, X = Cl; M = Cd, X = I) in an equimolar ratio. These group 12 metal complexes were characterised in solution by multinuclear NMR spectroscopy and their solid-state structures were determined by X-ray diffractometry. The ligands {(Me2)N^E^O((CH3)2)}(-) bearing CH3 groups in α position to the alkoxide behave as κ(2)-O,E-bidentate moieties (E = S, Se) and form centro-symmetric dinuclear O-bridged heteroleptic alkoxo-amido complexes both with zinc and cadmium, with four-coordinate metal centres resting in tetrahedral environments...
February 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28220610/comparison-and-analysis-on-the-serum-binding-characteristics-of-aspirin-zinc-complex-and-aspirin
#5
Hua-Xin Zhang, Qun Zhang, Hong-Lin Wang, Li-Wei Li
This study was designed to compare the protein-binding characteristics of aspirin-zinc complex (AZN) with those of aspirin itself. AZN was synthesized and interacted with a model transport protein, human serum albumin (HSA). Three-dimensional fluorescence, ultraviolet-visible and circular dichroism (CD) spectra were used to characterize the interaction of AZN with HSA under physiological conditions. The interaction mechanism was explored using a fluorescence quenching method and thermodynamic calculation. The binding site and binding locality of AZN on HSA were demonstrated using a fluorescence probe technique and Förster non-radiation energy transfer theory...
February 21, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28220537/immobilization-of-horseradish-peroxidase-on-zno-nanowires-macroporous-sio2-composites-for-the-complete-decolorization-of-anthraquinone-dyes
#6
Huaiyan Sun, Xinyu Jin, Feng Jiang, Ruifeng Zhang
A Zinc Oxide (ZnO) nanowires/ macroporous Silicon dioxide (SiO2 ) composite was used as support to immobilize horseradish peroxidase (HRP) simply by in-situ cross-linking method. As cross-linker was adsorbed on the surface of ZnO nanowires, the cross-linked HRP was quite different from the traditional cross-linking enzyme aggregates (CLEAs) on both structure and catalytic performance. Among three epoxy compounds diethylene glycol diglycidyl ether (DDE) was the best cross-linker, with which the loading amount of HRP with pI of 5...
February 21, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28220462/genome-editing-for-the-study-of-cardiovascular-diseases
#7
REVIEW
Alexandra C Chadwick, Kiran Musunuru
PURPOSE OF REVIEW: The opportunities afforded through the recent advent of genome-editing technologies have allowed investigators to more easily study a number of diseases. The advantages and limitations of the most prominent genome-editing technologies are described in this review, along with potential applications specifically focused on cardiovascular diseases. RECENT FINDINGS: The recent genome-editing tools using programmable nucleases, such as zinc-finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9), have rapidly been adapted to manipulate genes in a variety of cellular and animal models...
March 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28220127/nitric-oxide-ameliorates-zinc-oxide-nanoparticles-phytotoxicity-in-wheat-seedlings-implication-of-the-ascorbate-glutathione-cycle
#8
Durgesh K Tripathi, Rohit K Mishra, Swati Singh, Samiksha Singh, Kanchan Vishwakarma, Shivesh Sharma, Vijay P Singh, Prashant K Singh, Sheo M Prasad, Nawal K Dubey, Avinash C Pandey, Shivendra Sahi, Devendra K Chauhan
The present study investigates ameliorative effects of nitric oxide (NO) against zinc oxide nanoparticles (ZnONPs) phytotoxicity in wheat seedlings. ZnONPs exposure hampered growth of wheat seedlings, which coincided with reduced photosynthetic efficiency (Fv/Fm and qP), due to increased accumulation of zinc (Zn) in xylem and phloem saps. However, SNP supplementation partially mitigated the ZnONPs-mediated toxicity through the modulation of photosynthetic activity and Zn accumulation in xylem and phloem saps...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28219956/mineral-status-in-canine-medial-coronoid-process-disease-a-cohort-study-using-analysis-of-hair-by-mass-spectrometry
#9
M Davies, J West, C Williams, D S Gardner
In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs with or without medial coronoid process disease (MCPD). Dogs with MCPD have a different profile of minerals known to influence metalloenzymes involved in endochondral ossification. After cleansing, chelation and acid digestion of hair samples (n=79 in total: control dogs, n=70 v MCPD, n=9), mineral profile (7 major and 25 trace elements) was determined by inductively coupled plasma-mass spectrometry...
February 20, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28219737/membrane-androgen-receptor-characteristics-of-human-zip9-slc39a-zinc-transporter-in-prostate-cancer-cells-androgen-specific-activation-and-involvement-of-an-inhibitory-g-protein-in-zinc-and-map-kinase-signaling
#10
Peter Thomas, Yefei Pang, Jing Dong
Characteristics of novel human membrane androgen receptor (mAR), ZIP9 (SLC39A9), were investigated in ZIP9-transfected PC-3 cells (PC3-ZIP9). Ligand blot analysis showed plasma membrane [(3)H]-T binding corresponds to the position of ZIP9 on Western blots which suggests ZIP9 can bind [(3)H]-T alone, without a protein partner. Progesterone antagonized testosterone actions, blocking increases in zinc, Erk phosphorylation and apoptosis, further evidence that ZIP9 is specifically activated by androgens. Pre-treatment with GTPγS and pertussis toxin decreased plasma membrane [(3)H]-T binding and blocked testosterone-induced increases in Erk phosphorylation and intracellular zinc, indicating ZIP9 is coupled to an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling...
February 17, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28219689/in-vitro-drug-release-profiles-of-ph-sensitive-hydroxyethylacryl-chitosan-sodium-alginate-hydrogels-using-paracetamol-as-a-soluble-model-drug
#11
Pitchaya Treenate, Pathavuth Monvisade
The aim of this study is to investigate in vitro drug release profiles of pH-sensitive hydrogels composed of hydroxyethylacryl chitosan (HC) and sodium alginate (SA). The hydrogels were crosslinked by dipping method using different ionic crosslinkers (e.g., Ca(2+), Zn(2+) and Cu(2+)). The crosslinking reaction was confirmed by FT-IR. Swelling behavior and stability of the hydrogels in simulated digestive media were investigated. The result indicated that the combination between HC and SA could delay the degradation time of the hydrogels...
February 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28219048/arylsulfonamides-and-selectivity-of-matrix-metalloproteinase-2-an-overview
#12
REVIEW
Nilanjan Adhikari, Avinaba Mukherjee, Achintya Saha, Tarun Jha
Uncontrolled regulation of specific metalloenzymes plays important roles in several diseases like tumor metastasis and inflammation. Therefore, selective metalloenzyme inhibition may be a potential target for drug design and development. Matrix metalloproteinase inhibitors (MMPIs) opened up a new horizon as the possible treatment of arthritis, cancer, and emphysema. However, due to adverse effects and poor pharmacokinetics, first generation MMPIs failed in clinical trials. Therefore, development of potential and selective MMPIs is still in demand...
February 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28218639/genetic-variations-as-modifying-factors-to-dietary-zinc-requirements-a-systematic-review
#13
REVIEW
Kaitlin J Day, Melissa M Adamski, Aimee L Dordevic, Chiara Murgia
Due to reduced cost and accessibility, the use of genetic testing has appealed to health professionals for personalising nutrition advice. However, translation of the evidence linking polymorphisms, dietary requirements, and pathology risk proves to be challenging for nutrition and dietetic practitioners. Zinc status and polymorphisms of genes coding for zinc-transporters have been associated with chronic diseases. The present study aimed to systematically review the literature to assess whether recommendations for zinc intake could be made according to genotype...
February 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28218528/a-water-stable-anionic-metal-organic-framework-constructed-from-columnar-zinc-adeninate-units-for-highly-selective-light-hydrocarbon-separation-and-efficient-separation-of-organic-dyes
#14
Hui-Fang Ma, Qing-Yan Liu, Yu-Ling Wang, Shun-Gao Yin
A metal-organic framework (MOF), {(Me2NH2)2[Zn6(μ4-O)(ad)4(BPDC)4]}n (JXNU-4; ad(-) = adeninate), with an anionic three-dimensional (3D) framework constructed from one-dimensional (1D) columnar [Zn6(ad)4(μ4-O)]n secondary building units (SBUs) and 4,4'-biphenyldicarboxylate (BPDC(2-)) ligand, was prepared. The anionic 3D framework has 1D square channels with an aperture of about 9.8 Å and exhibits a carboxylate-O-decorated pore environment. The microporous nature of JXNU-4 was established by the N2 adsorption data, which gives Langmuir and Brumauer-Emmett-Teller surface areas of 1800 and 1250 m(2) g(-1), respectively...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28218485/mechanically-milled-irregular-zinc-nanoparticles-for-printable-bioresorbable-electronics
#15
Bikram K Mahajan, Xiaowei Yu, Wan Shou, Heng Pan, Xian Huang
Bioresorbable electronics is predominantly realized by complex and time-consuming anhydrous fabrication processes. New technology explores printable methods using inks containing micro- or nano-bioresorbable particles (e.g., Zn and Mg). However, these particles have seldom been obtained in the context of bioresorbable electronics using cheap, reliable, and effective approaches with limited study on properties essential to printable electronics. Here, irregular nanocrystalline Zn with controllable sizes and optimized electrical performance is obtained through ball milling approach using polyvinylpyrrolidone (PVP) as a process control agent to stabilize Zn particles and prevent cold welding...
February 20, 2017: Small
https://www.readbyqxmd.com/read/28218276/natural-and-laboratory-mutations-in-kuzbanian-are-associated-with-zinc-stress-phenotypes-in-drosophila-melanogaster
#16
Hung Le Manh, Lain Guio, Miriam Merenciano, Quirze Rovira, Maite G Barrón, Josefa González
Organisms must cope with altered environmental conditions such as high concentrations of heavy metals. Stress response to heavy metals is mediated by the metal-responsive transcription factor 1 (MTF-1), which is conserved from Drosophila to humans. MTF-1 binds to metal response elements (MREs) and changes the expression of target genes. kuzbanian (kuz), a metalloendopeptidase that activates the evolutionary conserved Notch signaling pathway, has been identified as an MTF-1 target gene. We have previously identified a putatively adaptive transposable element in the Drosophila melanogaster genome, named FBti0019170, inserted in a kuz intron...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217951/cytotoxic-effect-of-zinc-oxide-nanoparticles-on-murine-photoreceptor-cells-via-potassium-channel-block-and-na-k-atpase-inhibition
#17
Chao Chen, Wenjuan Bu, Hongyan Ding, Qin Li, Dabo Wang, Hongsheng Bi, Dadong Guo
OBJECTIVE: Zinc oxide (ZnO) nanoparticles can exhibit toxicity towards organisms and oxidative stress is often hypothesized to be one of the most important factors. Nevertheless, the detailed mechanism of toxicity-induced by ZnO nanoparticles has not been completely addressed. The present study aimed to investigate the toxic effects of ZnO nanoparticles on the expression and activity of Na(+) /K(+) -ATPase and on potassium channel block. MATERIALS AND METHODS: In the present study, we explored the cytotoxic effect of ZnO nanoparticles on murine photoreceptor cells using lactate dehydrogenase (LDH) release assay, reactive oxygen species (ROS) determination, mitochondrial membrane potential (Δφm) measurement, delayed rectifier potassium current recordings and Na(+) /K(+) -ATPase expression and activity monitoring...
February 19, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28217840/a-comparison-of-us-and-japanese-dental-restorative-care-present-on-service-members-recovered-from-the-wwii-era
#18
Calvin Y Shiroma
The documentation of dental materials used in the USA during the WWII era is readily available, while references for the Japanese are minimal. It was therefore important to build a photographic database of Japanese restorative care which could be utilized as a comparison tool for the deployed odontologist. The dental restorative care of approximately 400 US and 100 Japanese sets of remains was evaluated. Both countries share many similar restorative techniques to include collared crowns, full-coverage restorations, cantilever bridge/pontics to close spaces; restorative materials such as amalgam, gold, and zinc phosphate (temporary) restorations; and removable prostheses...
February 20, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28217743/regulation-of-nitrogen-metabolism-by-gata-zinc-finger-transcription-factors-in-yarrowia-lipolytica
#19
Kyle R Pomraning, Erin L Bredeweg, Scott E Baker
Fungi accumulate lipids in a manner dependent on the quantity and quality of the nitrogen source on which they are growing. In the oleaginous yeast Yarrowia lipolytica, growth on a complex source of nitrogen enables rapid growth and limited accumulation of neutral lipids, while growth on a simple nitrogen source promotes lipid accumulation in large lipid droplets. Here we examined the roles of nitrogen catabolite repression and its regulation by GATA zinc finger transcription factors on lipid metabolism in Y...
January 2017: MSphere
https://www.readbyqxmd.com/read/28216891/effects-of-potassium-sulfate-k2so4-on-the-element-contents-polyphenol-content-antioxidant-and-antimicrobial-activities-of-milk-thistle-silybum-marianum
#20
Gulsum Yaldiz
BACKGROUND: Silybum marianum L. (Milk thistle) is native to the Mediterranean basin and is now widespread throughout the world. It's sprout is used as a herbal medicine for the treatment of liver disease for centuries. The seeds of milk thistle contain silymarin, an isomeric mixture of flavonolignans [silybin, silychristin, and silydianin]. Silymarin acts as a strong anti-hepatotoxic. OBJECTIVES: The objective of this study was to evaluate the influences of potassium sulfate [K2SO4] fertilizer doses on polyphenol content, some nutrient elements, antioxidant and antimicrobial activities of milk thistle at experimental fields of Ordu University in Turkey...
January 2017: Pharmacognosy Magazine
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