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https://www.readbyqxmd.com/read/29150958/inhibition-of-mir-200b-mir-429-contributes-to-neuropathic-pain-development-through-targeting-zinc-finger-e-box-binding-protein-1
#1
Xue-Tao Yan, Ying Zhao, Xiao-Li Cheng, Xiang-Hu He, Yu Wang, Wen-Zhong Zheng, Hu Chen, Yan-Lin Wang
Many studies have reported that microRNAs participate in neuropathic pain development. Previously, miR-200b and miR-429 are reported to be involved in various diseases. In our current study, we focused on their roles in neuropathic pain and we found that miR-200b and miR-429 were significantly decreased in chronic constriction injury (CCI) rat spinal cords and isolated microglials. miR-200b and miR-429 overexpression were able to relieve neuropathic pain through modulating PWT and PWL in CCI rats. Meanwhile, we observed that both miR-200b and miR-429 upregulation could repress neuroinflammation via inhibiting inflammatory cytokines such as IL-6, IL-1β and TNF-α in CCI rats...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150940/tumor-suppressive-roles-of-%C3%AE-np63%C3%AE-mir-205-axis-in-epithelial-mesenchymal-transition-of-oral-squamous-cell-carcinoma-via-targeting-zeb1-and-zeb2
#2
Yuma Hashiguchi, Shintaro Kawano, Yuichi Goto, Kaori Yasuda, Naoki Kaneko, Taiki Sakamoto, Ryota Matsubara, Teppei Jinno, Yasuyuki Maruse, Hideaki Tanaka, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Tamotsu Kiyoshima, Seiji Nakamura
We previously revealed that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β, a splicing variant of ΔNp63, in oral squamous cell carcinoma (OSCC). Recent studies have highlighted the involvement of microRNA (miRNA) in EMT of cancer cells, though the mechanism remains unclear. To identify miRNAs responsible for ΔNp63β-mediated EMT, miRNA microarray analyses were performed by ΔNp63β-overexpression in OSCC cells; SQUU-B, which lacks ΔNp63 expression and displays EMT phenotypes. miRNAs microarray analyses revealed miR-205 was the most up-regulated following ΔNp63β-overexpression...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150876/toxicological-characterization-of-zno-nanoparticles-in-malignant-and-non-malignant-cells
#3
Helena Moratin, Agmal Scherzad, Thomas Gehrke, Pascal Ickrath, Katrin Radeloff, Norbert Kleinsasser, Stephan Hackenberg
The increasing usage of zinc oxide nanoparticles (ZnO-NPs) in industrial applications as well as in consumer products raises concern regarding their potential adverse effects to a greater extend. Numerous studies have demonstrated toxic properties of NPs, however there is still a lack of knowledge concerning the underlying mechanisms. This study was designed to systematically investigate cytotoxicity, apoptosis, cell cycle alterations, and genotoxicity induced by ZnO-NP. Moreover, it was an aim of the investigations to specify the diverse effects of nanoparticle exposure in malignant in comparison with non-malignant cells...
November 18, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29150244/proteomic-analysis-of-follicular-fluid-from-tropically-adapted-goats
#4
Alexandre R Paula Junior, Mauricio F van Tilburg, Marina D P Lobo, Ana C O Monteiro-Moreira, Renato A Moreira, Carlos H S Melo, Joanna M G Souza-Fabjan, Airton A Araújo, Luciana M Melo, Dárcio I A Teixeira, Arlindo A Moura, Vicente J F Freitas
The present study was conducted to characterize the major proteome of ovarian follicular fluid from locally-adapted, "Canindé" goats in the northeast of Brazil. Eight estrous cycling goats received a hormonal treatment consisting of medroxyprogesterone acetate, D-cloprostenol and FSH. Fluid was collected by laparoscopy from small (<3mm), medium (3-4mm) and large (>4mm) follicles and then, proteins were analyzed by 2-D SDS-PAGE and tandem mass spectrometry. Thirty-six proteins were identified in the goat follicular fluid, including albumin, immunoglobulins, ceruloplasmin, complement factor B, alpha-1B-glycoprotein precursor, serotransferrin, complement C3 and serpins, among others...
November 6, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29149619/association-of-snps-in-genes-encoding-zinc-transporters-on-blood-zinc-levels-in-humans
#5
Junko Fujihara, Toshihiro Yasuda, Kaori Kimura-Kataoka, Yoshikazu Takinami, Masataka Nagao, Haruo Takeshita
Zinc homeostasis in cells depends on zinc transporters, which are divided into 2 families: ZnT (SLC30A) and ZIP (SLC39A). In this study, we examined the effect of 20 single nucleotide polymorphisms (SNPs) in 10 genes encoding zinc transporters on blood zinc concentration in Japanese subjects (n = 102). Blood zinc levels were determined by microwave plasma-atomic emission spectrometry, and SNPs were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism analysis. Among the 20 SNPs examined, 3 SNPs (SLC30A3 rs11126936, SLC39A8 rs233804, and SLC39A14 rs4872479) were significantly associated with blood zinc concentration...
November 9, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29149560/the-extended-zinc-amber-force-field-ezaff
#6
Zhuoqin Yu, Pengfei Li, Kenneth M Merz
An empirical approach based on the previously developed zinc AMBER force field (ZAFF) is proposed for the determination of the parameters for bonds and angles involving zinc. We call it the extended ZAFF (EZAFF) model because the original ZAFF model was only formulated for 4-coordinated systems, while EZAFF additionally can tackle 5- and 6-coordinated systems. Tests were carried out for 6 metalloproteins and 5 organometallic compounds with different coordination spheres. Results validated the reliability of the current model to handle a variety of zinc containing complexes...
November 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29149555/mapping-the-reactions-in-a-single-zero-valent-iron-nanoparticle
#7
Lan Ling, Xiao-Yue Huang, Meirong Li, Wei-Xian Zhang
Nanoscale zero-valent iron (nZVI) posseses unique functionalities for metal-metalloid removal and sequestration. So far, direct evidence on the heavy metal-iron reactions in the solid phase is still limited due to low concentration of heavy metals and small size of nanoparticles. In this work, angstrom-resolution spectral mappings on the reactions of nZVI with chromate, arsenate, nickel, silver, cesium, and zinc ions are presented. This work was achieved with spherical aberration-corrected scanning transmission electron microscopy integrated with high-sensitivity X-ray energy-dispersive spectroscopy scanning transmission electron microscopy (XEDS-STEM)...
November 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29149397/heavily-graphitic-nitrogen-self-doped-high-porosity-carbon-for-the-electrocatalysis-of-oxygen-reduction-reaction
#8
Tong Feng, Wenli Liao, Zhongbin Li, Lingtao Sun, Dongping Shi, Chaozhong Guo, Yu Huang, Yi Wang, Jing Cheng, Yanrong Li, Qizhi Diao
Large-scale production of active and stable porous carbon catalysts for oxygen reduction reaction (ORR) from protein-rich biomass became a hot topic in fuel cell technology. Here, we report a facile strategy for synthesis of nitrogen-doped porous nanocarbons by means of a simple two-step pyrolysis process combined with the activation of zinc chloride and acid-treatment process, in which kidney bean via low-temperature carbonization was preferentially adopted as the only carbon-nitrogen sources. The results show that this carbon material exhibits excellent ORR electrocatalytic activity, and higher durability and methanol-tolerant property compared to the state-of-the-art Pt/C catalyst for the ORR, which can be mainly attributed to high graphitic-nitrogen content, high specific surface area, and porous characteristics...
November 17, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29149209/correction-comparison-of-porous-and-nano-zinc-oxide-for-replacing-high-dose-dietary-regular-zinc-oxide-in-weaning-piglets
#9
Lina Long, Jiashun Chen, Yonggang Zhang, Xiao Liang, Hengjia Ni, Bin Zhang, Yulong Yin
[This corrects the article DOI: 10.1371/journal.pone.0182550.].
2017: PloS One
https://www.readbyqxmd.com/read/29149053/laser-induced-breakdown-spectroscopy-for-rapid-discrimination-of-heavy-metal-contaminated-seafood-tegillarca-granosa
#10
Guoli Ji, Pengchao Ye, Yijian Shi, Leiming Yuan, Xiaojing Chen, Mingshun Yuan, Dehua Zhu, Xi Chen, Xinyu Hu, Jing Jiang
Tegillarca granosa samples contaminated artificially by three kinds of toxic heavy metals including zinc (Zn), cadmium (Cd), and lead (Pb) were attempted to be distinguished using laser-induced breakdown spectroscopy (LIBS) technology and pattern recognition methods in this study. The measured spectra were firstly processed by a wavelet transform algorithm (WTA), then the generated characteristic information was subsequently expressed by an information gain algorithm (IGA). As a result, 30 variables obtained were used as input variables for three classifiers: partial least square discriminant analysis (PLS-DA), support vector machine (SVM), and random forest (RF), among which the RF model exhibited the best performance, with 93...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29148959/effect-of-measuring-%C3%AE-glutamyl-transpeptidase-and-using-smoflipid-in-a-parenteral-nutrition-infusion-in-a-patient-with-severe-malabsorption-and-overlapping-primary-sclerosing-cholangitis-and-ulcerative-colitis
#11
Merin Kinikini
Studies discussing inflammation and oxidative stress state that these conditions are known contributors in the pathogenesis of cholestatic diseases and ulcerative colitis, and studies examining patients with liver disease have found decreased antioxidant status and significant elevation of lipid peroxides as compared with healthy subjects. One hypothesis in liver disease is that deficient antioxidant defense mechanisms may lead to excess oxygen free radical formation, which promotes deleterious processes in the liver...
November 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29148794/preparation-and-formation-process-of-zn-ii-coordinated-nanovesicles
#12
Wuxiao Ding, Naohiro Kameta, Hiroyuki Minamikawa, Mitsutoshi Masuda, Masaki Kogiso
Mixing a glycylglycine-lipid and zinc acetate has been reported to form novel supramolecular Zn(II)-coordinated nanovesicles in ethanol. In this study, we investigate in detail the formation of nanovesicles by using three lipids at different temperatures and discuss their formation process. The original lipids show extremely low solubilities and appear as plate structures in ethanol. Within a small window of lipid solubility, the formation of lipid-Zn(II) complexes occurs mainly on the solid surfaces of plate structures...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29148741/controlling-association-and-separation-of-gold-nanoparticles-with-computationally-designed-zinc-coordinating-proteins
#13
Matthew J Eibling, Christopher M MacDermaid, Zhaoxia Qian, Christopher J Lanci, So-Jung Park, Jeffery G Saven
Functionalization of nanoparticles with biopolymers has yielded a wide range of structured and responsive hybrid materials. DNA provides the ability to program length and recognition using complementary oligonucleotide sequences. Nature more often leverages the versatility of proteins, however, where structure, assembly, and recognition are more subtle to engineer. Herein, a protein was computationally designed to present multiple Zn(2+) coordination sites and cooperatively self-associate to form an antiparallel helical homodimer...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29148143/leaf-cell-membrane-stability-based-mechanisms-of-zinc-nutrient-in-mitigation-of-salinity-stress-in-rice
#14
Abdullah Tufail, Hong Li, Asif Naeem, Tingxian Li
Excess salts affect about 955 million ha of total arable lands worldwide and 49% of agricultural lands are Zn deficient. Soil salinity and zinc deficiency can intensify plant abiotic stress. The mechanisms by which Zn nutrients can mitigate salinity effects on plant functions are not well understood. We conducted an experiment to determine the zinc and salinity effects on rice plant retention of Zn, macronutrient potassium (K) and salt ion Na, chlorophyll formation, leaf cell membrane stability and grain yield, and to examine the mechanisms of zinc nutrition in mitigating salinity stress on plant physiological and nutritional aspects...
November 16, 2017: Plant Biology
https://www.readbyqxmd.com/read/29147778/genome-wide-investigation-of-transcription-factors-provides-insights-into-transcriptional-regulation-in-plutella-xylostella
#15
Qian Zhao, Dongna Ma, Yuping Huang, Weiyi He, Yiying Li, Liette Vasseur, Minsheng You
Transcription factors (TFs), which play a vital role in regulating gene expression, are prevalent in all organisms and characterization of them may provide important clues for understanding regulation in vivo. The present study reports a genome-wide investigation of TFs in the diamondback moth, Plutella xylostella (L.), a worldwide pest of crucifers. A total of 940 TFs distributed among 133 families were identified. Phylogenetic analysis of insect species showed that some of these families were found to have expanded during the evolution of P...
November 16, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29147699/strain-relaxation-and-ambipolar-electrical-transport-in-gaas-insb-core-shell-nanowires
#16
Torsten Rieger, Patrick Zellekens, Natalia Demarina, Ali Al Hassan, Franz Josef Hackemüller, Hans Lüth, Ullrich Pietsch, Thomas Schäpers, Detlev Grützmacher, Mihail Ion Lepsa
The growth, crystal structure, strain relaxation and room temperature transport characteristics of GaAs/InSb core-shell nanowires grown using molecular beam epitaxy are investigated. Due to the large lattice mismatch between GaAs and InSb of 14%, a transition from island-based to layer-like growth occurs during the formation of the shell. High resolution transmission electron microscopy in combination with geometric phase analyses as well as X-ray diffraction with synchrotron radiation are used to investigate the strain relaxation and prove the existence of different dislocations relaxing the strain on zinc blende and wurtzite core-shell nanowire segments...
November 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/29147692/topological-transformation-of-a-trefoil-knot-into-a-2-catenane
#17
Thirumurugan Prakasam, Rana A Bilbeisi, Roberto El-Khoury, Loïc J Charbonnière, Mourad Elhabiri, Gennaro Esposito, John-Carl Olsen, Ali Trabolsi
Topological transformation of a zinc-templated trefoil knot, Zn-TK, into a zinc-templated [2]catenane, Zn-[2]C, was studied. The net reaction 2 Zn-TK → 3 Zn-[2]C was accomplished in 89% yield by heating a solution of Zn-TK in D2O. Kinetic investigation by (1)H NMR spectroscopy and high resolution mass spectrometry revealed that the mechanism is complex, involving a large pool of intermediates that form after imine bond cleavage. Bromide ions, which can occupy the central cavity of Zn-TK, inhibited the reaction...
November 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29147483/sonophotodynamic-therapy-mediated-by-liposomal-zinc-phthalocyanine-in-a-colon-carcinoma-tumor-model-role-of-irradiating-arrangement
#18
Maryam Bakhshizadeh, Toktam Moshirian, Habibollah Esmaily, Omid Rajabi, Hooriyeh Nassirli, Ameneh Sazgarnia
Objectives: Low penetration depth of light is the main defect of photodynamic therapy (PDT), which could be improved by sonodynamic therapy (SDT). In this study, a combination of PDT and SDT known as sonophotodynamic therapy (SPDT) was investigated using two reverse arrangements in CT26 tumor model. Materials and Methods: The liposomal zinc phthalocyanine was synthesized and characterized. It was then administered to CT26 tumor models as a sensitizer. The animal models were subjected to PDT, SDT, and the combined treatment in different groups...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29147139/insights-into-the-management-of-wilson-s-disease
#19
REVIEW
Mohmadshakil Kathawala, Gideon M Hirschfield
Wilson's disease is a rare, inherited autosomal recessive disease of copper metabolism, in which the causative gene, ATP7B, results in absent or reduced function of the ATP7B transporter important for biliary excretion of copper and incorporation of copper into caeruloplasmin. Affected patients accumulate excessive copper within the liver, brain and other tissues. A disease mainly of children, adolescents and young adults; clinical features vary from the asymptomatic state to chronic liver disease, acute liver failure, and neuropsychiatric manifestations...
November 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29146988/variations-in-nutrient-and-trace-element-composition-of-rice-in-an-organic-rice-frog-coculture-system
#20
Zhimin Sha, Qingnan Chu, Zheng Zhao, Yubo Yue, Linfang Lu, Jing Yuan, Linkui Cao
Introducing frogs into paddy fields can control pests and diseases, and organic farming can improve soil fertility and rice growth. The aim of this 2-year field study was compare the yield and elemental composition of rice between an organic farming system including frogs (ORF) and a conventional rice culture system (CR). The grain yields were almost the same in the ORF system and the CR system. The ORF significantly increased the contents of phosphorus (P), ion (Fe), zinc (Zn), molybdenum (Mo) and selenium (Se) in rice grain at one or both years...
November 16, 2017: Scientific Reports
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