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https://www.readbyqxmd.com/read/28749469/zinc-oxide-nanoparticles-harness-autophagy-to-induce-cell-death-in-lung-epithelial-cells
#1
Jun Zhang, Xia Qin, Bin Wang, Ge Xu, Zhexue Qin, Jian Wang, Lanxiang Wu, Xiangwu Ju, Diptiman D Bose, Feng Qiu, Honghao Zhou, Zhen Zou
Although zinc oxide nanoparticles (ZnONPs) are widely used, they have raised concerns of toxicity in humans. Previous studies have indicated that reactive oxygen species (ROS) and autophagy are involved in the cytotoxicity of ZnONPs, but the regulatory mechanisms between autophagy and ROS remain to be elucidated. Herein, we comprehensively investigated the regulatory mechanism of autophagy and the link between autophagy and ROS in ZnONPs-treated lung epithelial cells. We demonstrated that ZnONPs could induce autophagy, and this process could enhance the dissolution of ZnONPs in lysosomes to release zinc ions...
July 27, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28748977/solvent-dependent-photo-induced-dynamics-in-a-non-rigidly-linked-zinc-phthalocyanine-perylenediimide-dyad-probed-using-ultrafast-spectroscopy
#2
Bryan Kudisch, Margherita Maiuri, Vicente M Blas-Ferrando, Javier Ortiz, Ángela Sastre-Santos, Gregory D Scholes
In this work, we characterize the energy and electron transfer kinetics of a zinc phthalocyanine-perylenediimide dyad (ZnPc-PDI) in various solvents using steady-state and tunable narrowband pump-probe spectroscopy. We fit the ultrafast data with global analysis techniques and find that upon excitation of the PDI moiety (pump pulse at 540 nm), the excitation energy transfer (EET) rate to the ZnPc moiety displays a solvent sensitivity that we attribute to changes in the relative equilibrium moiety orientation...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28748607/simultaneous-detection-of-zinc-dimethyldithiocarbamate-and-zinc-ethylenebisdithiocarbamate-in-cabbage-leaves-by-capillary-electrophoresis-with-inductively-coupled-plasma-mass-spectrometry
#3
Jinfa Chen, Fengfu Fu, Siying Wu, Jing Wang, Zongwen Wang
Herein, a simple and highly sensitive method for the simultaneous detection of trace zinc dimethyldithiocarbamate and zinc ethylenebisdithiocarbamate by capillary electrophoresis with inductively coupled plasma mass spectrometry is reported. Zinc dimethyldithiocarbamate and zinc ethylenebisdithiocarbamate were chelated with trans-1,2-diaminocyclohexane-N,N,N´,N´-tetraacetic acid to form a macromolecule complex. Then, these two compounds were separated by α-cyclodextrin-modified capillary electrophoresis within 12 min at a separation voltage of 15 kV and measured by inductively coupled plasma mass spectrometry...
July 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28747546/inhibition-of-avian-tumor-virus-replication-by-ccch-type-zinc-finger-antiviral-protein
#4
Mingjun Zhu, Xiaoqian Ma, Xiyao Cui, Jing Zhou, Chengui Li, Libo Huang, Yingli Shang, Ziqiang Cheng
CCCH type zinc finger antiviral protein (ZAP) is a host restriction factor that inhibits the replication of a variety of viruses in mammals. However, little is known about its antiviral activity on avian tumor virus. Avian leukosis virus subgroup J (ALV-J), an oncogenic retrovirus, induces myelocytomas and various other tumors in meat and egg type chickens. Here, we identified a chicken ZAP (chZAP) that increased at early stage, and subsequently decreased after infection of ALV-J in DF-1 cells, indicating the inducible feature of the endogenous chZAP...
July 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747487/plasma-f2-isoprostanes-are-positively-associated-with-glycemic-load-but-inversely-associated-with-dietary-polyunsaturated-fatty-acids-and-insoluble-fiber-in-postmenopausal-women
#5
Andrea Y Arikawa, Hamed Samavat, Myron Gross, Mindy S Kurzer
Background: Dietary factors, such as antioxidant nutrients, contribute significantly to the maintenance of an appropriate balance between antioxidant defense and free radical production in the body.Objective: The objective of this study was to examine the relation between oxidative stress as assessed by plasma F2-isoprostane (IsoP) concentration, glycemic load (GL), glycemic index (GI), intake of antioxidant nutrients, dietary fiber, and polyunsaturated fatty acids (PUFAs).Methods: This study was a cross-sectional secondary analysis of baseline data collected from a random sample of 269 postmenopausal women participating in the Minnesota Green Tea Trial...
July 26, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28747437/crystal-structure-of-the-human-pol%C3%AF%C2%B5-b-subunit-in-complex-with-the-c-terminal-domain-of-the-catalytic-subunit
#6
Andrey G Baranovskiy, Jianyou Gu, Nigar D Babayeva, Igor Kurinov, Youri I Pavlov, Tahir H Tahirov
The eukaryotic B-family DNA polymerases include four members, Polα, Polδ, Polϵ, and Polζ, which share common architectural features, such as the exonuclease/polymerase and C-terminal domains (CTDs) of catalytic subunits bound to indispensable B-subunits, which serve as scaffolds that mediate interactions with other components of the replication machinery. Crystal structures for the B-subunits of Polα and Polδ/Polζ have been reported; the former within the primosome and separately with CTD, and the latter with the N-terminal domain (NTD) of the C-subunit...
July 26, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28747335/crosstalk-between-intracellular-zinc-rises-and-reactive-oxygen-species-accumulation-in-chemical-ischemia
#7
Kira G Slepchenko, Qiping Lu, Yang V Li
Both zinc (Zn(2+)) and reactive oxygen species (ROS) have been shown to accumulate during hypoxic-ischemic stress and play important roles in pathological processes. Here we studied Zn(2+) and ROS accumulations by employing fluorescent probes in HeLa cells to further the understanding of cause and effect relationship of these two important cellular signaling during chemical-ischemia, stimulated by oxygen and glucose deprivation (OGD). We observed two Zn(2+) rises that were divided into four phases in the course of 30 minutes OGD...
July 26, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28747224/regions-of-common-inter-individual-dna-methylation-differences-in-human-monocytes-genetic-basis-and-potential-function
#8
Christopher Schröder, Elsa Leitão, Stefan Wallner, Gerd Schmitz, Ludger Klein-Hitpass, Anupam Sinha, Karl-Heinz Jöckel, Stefanie Heilmann-Heimbach, Per Hoffmann, Markus M Nöthen, Michael Steffens, Peter Ebert, Sven Rahmann, Bernhard Horsthemke
BACKGROUND: There is increasing evidence for inter-individual methylation differences at CpG dinucleotides in the human genome, but the regional extent and function of these differences have not yet been studied in detail. For identifying regions of common methylation differences, we used whole genome bisulfite sequencing data of monocytes from five donors and a novel bioinformatic strategy. RESULTS: We identified 157 differentially methylated regions (DMRs) with four or more CpGs, almost none of which has been described before...
July 26, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28747081/fabrication-characterization-and-in%C3%A2-vitro-study-of-zinc-substituted-hydroxyapatite-silk-fibroin-composite-coatings-on-titanium-for-biomedical-applications
#9
Zhenyu Zhong, Jun Ma
Zinc substituted hydroxyapatite/silk fibroin composite coatings were deposited on titanium substrates at room temperature by electrophoretic deposition. Microscopic characterization of the synthesized composite nanoparticles revealed that the particle size ranged 50-200 nm, which increased a little after zinc substitution. The obtained coatings maintained the phase of hydroxyapatite and they could induce fast apatite formation in simulated body fluid, indicating high bone activity. The cell culturing results showed that the biomimetic hydroxyapatite coatings could regulate adhesion, spreading, and proliferation of osteoblastic cells...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28746891/long-term-variations-in-sediment-heavy-metals-of-a-reservoir-with-changing-trophic-states-implications-for-the-impact-of-climate-change
#10
Qiong Wu, Jun Qi, Xinghui Xia
Two dated sediment cores from the Miyun Reservoir of Beijing in China were analyzed to reconstruct the pollution history of heavy metals including cadmium (Cd), chromium (Cr), iron (Fe), nickel (Ni), and zinc (Zn) as well as phosphorus (P). Enrichment factor (EF) and geoaccumulation index (Igeo) were applied to assess the enrichment status of heavy metals. Average EF and Igeo values indicated that the studied heavy metals in the sediments mainly originated from non-point source pollution and soil-water erosion, showing low ecological risks...
July 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28746890/aged-engineered-nanoparticles-effect-on-sludge-anaerobic-digestion-performance-and-associated-microbial-communities
#11
Samuel Eduok, Robert Ferguson, Bruce Jefferson, Raffaella Villa, Frédéric Coulon
To investigate the potential effect of aged engineered nanoparticles (a-ENPs) on sludge digestion performance, 150L pilot anaerobic digesters (AD) were fed with a blend of primary and waste activated sludge spiked either with a mixture of silver oxide, titanium dioxide and zinc oxide or a mixture of their equivalent bulk metal salts to achieve a target concentration of 250, 2000, and 2800mgkg(-1) dry weight, respectively. Volatile fatty acids (VFA) were 1.2 times higher in the spiked digesters and significantly different (p=0...
July 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28746878/the-type-vi-secretion-system-engages-a-redox-regulated-dual-functional-heme-transporter-for-zinc-acquisition
#12
Meiru Si, Yao Wang, Bing Zhang, Chao Zhao, Yiwen Kang, Haonan Bai, Dawei Wei, Lingfang Zhu, Lei Zhang, Tao G Dong, Xihui Shen
The type VI secretion system was recently reported to be involved in zinc acquisition, but the underlying mechanism remains unclear. Here, we report that Burkholderia thailandensis T6SS4 is involved in zinc acquisition via secretion of a zinc-scavenging protein, TseZ, that interacts with the outer membrane heme transporter HmuR. We find that HmuR is a redox-regulated dual-functional transporter that transports heme iron under normal conditions but zinc upon sensing extracellular oxidative stress, triggered by formation of an intramolecular disulfide bond...
July 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28746739/characterization-and-influence-of-green-synthesized-of-nano-sized-zinc-complex-with-5-aminolevulinic-acid-on-bioactive-compounds-of-aniseed
#13
Vahid Tavallali, Sadegh Rahmati, Vahid Rowshan
A new water soluble zinc-aminolevulinic acid nano complex (n[Zn(ALA)2 ]), which characterized by TEM, IR and EDX spectra, has been prepared via sonochemical method under green conditions in water. In the current study, the effectiveness of foliar Zn amendment using synthetic Zn-ALA nano complex, as a new introduced Zn-fertilizer here, was evaluated. As the model plant, Pimpinella anisum, the most valuable spice and medicinal plant grown in warm regions, was used. By using zinc nano complex, further twenty compounds were obtained in the essential oil of anise plants...
July 26, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28746617/resistance-of-xanthomonas-euvesicatoria-strains-from-brazilian-pepper-to-copper-and-zinc-sulfates
#14
Maysa S Areas, Ricardo M Gonçalves, José M Soman, Ronaldo C Souza, Ricardo Gioria, Tadeu A F DA Silva, Antonio C Maringoni
Bacterial spot, caused by Xanthomonas spp., is one of the major bacterial diseases in pepper (Capsicum annuum L.). The infection results in reduced crop yield, particularly during periods of high rainfall and temperature, due to the low efficiency of chemical control with copper bactericides. This study evaluated the copper and zinc sulfate sensitivity of 59 pathogenic strains of Xanthomonas euvesicatoria isolated from pepper plants produced in various regions throughout Brazil. Both the respective sulfates and a mixture thereof was evaluated at 50, 100, 200 and 400 μg...
July 24, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28746059/nutrition-micronutrients-in-child-growth-and-development-a-systematic-review-on-current-evidence-recommendations-and-opportunities-for-further-research
#15
Mohammad Yawar Yakoob, Clifford W Lo
OBJECTIVE: An important aspect of malnutrition is deficiency of different micronutrients during pregnancy or early childhood. We systematically reviewed the role of nutrition in child growth (weight or height gain) and development. METHODS: A comprehensive literature search was done on PubMed/Cochrane Library browsing through 38,795 abstracts until December 31, 2016 to select systematic reviews/meta-analyses and individual randomized controlled trials (RCTs) of micronutrient supplementation...
July 25, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28745839/transcription-factor-agseb1-affects-development-osmotic-stress-response-and-secondary-metabolism-in-marine-derived-aspergillus-glaucus
#16
Yuan Wu, Yanna Ren, Xiangshan Zhou, Menghao Cai, Yuanxing Zhang
Fungi possess sophisticated regulatory systems to respond to a vast array of environmental signals. Among these responsive networks, some genes play critical roles in the regulation of various cellular processes. Here, we identified a putative transcriptional factor Agseb1 in Aspergillus glaucus, a marine-derived filamentous fungus. Agseb1 encodes a protein with two C2 H2 zinc fingers at the C-terminus, similar to the placement of these motifs in msn2/4 of Saccharomyces cerevisia, where they are positioned to allow binding to the CCCCT-box of stress-specific genes...
July 26, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28745731/zinc-coordination-and-c-peptide-complexation-a-potential-mechanism-for-the-endogenous-inhibition-of-iapp-aggregation
#17
Xinwei Ge, Aleksandr Kakinen, Esteban N Gurzov, Wen Yang, Lokman Pang, Emily H Pilkington, Praveen Govindan-Nedumpully, Pengyu Chen, Frances Separovic, Thomas P Davis, Pu Chun Ke, Feng Ding
Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion molecular complex with C-peptide might be important for the endogenous inhibition of IAPP aggregation.
July 26, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28745357/defect-induced-p-type-conductivity-in-zinc-oxide-at-high-temperature-electron-paramagnetic-resonance-spectroscopy
#18
Emre Erdem
High-temperature electron paramagnetic resonance (EPR) measurements were applied to a ZnO nanocrystalline (50 nm) sample, synthesized via a solid co-precipitation method, in order to understand the behavior of intrinsic defect centers at high temperatures. It has been observed that the defect centers on the surface play a crucial role in the conductivity behavior of ZnO. Above 300 °C only surface defects can be visible in EPR spectra for ZnO nanocrystals which indicate p-type conductivity.
July 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28744810/kr%C3%A3-ppel-like-factor-4-regulates-the-expression-of-inducible-nitric-oxide-synthase-induced-by-tnf-%C3%AE-in-human-fibroblast-like-synoviocyte-mh7a-cells
#19
Xuanrong Mo, Jie Chen, Xinjuan Wang, Zhenyu Pan, Yuping Ke, Zhidong Zhou, Jiangwen Xie, Guoju Lv, Xinjing Luo
Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, has been implicated in the inflammation mediated by macrophages and endothelial cells by regulating the expression of inflammatory mediators. Here, we investigated whether KLF4 affects the expression of inducible nitric oxide synthase (iNOS), an important inflammatory mediator, in the human RA fibroblast-like synovial cell line MH7A. A pcDNA3.1-KLF4 plasmid or short interfering RNA KLF4 was transfected into MH7A cells, and the iNOS expression and nitric oxide (NO) production were analyzed by quantitative PCR, immunoblotting, and nitrite measurement...
July 25, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28744681/an-analysis-of-variable-dissolution-rates-of-sacrificial-zinc-anodes-a-case-study-of-the-hamble-estuary-uk
#20
Aldous B Rees, Anthony Gallagher, Sean Comber, Laurence A Wright
Sacrificial anodes are intrinsic to the protection of boats and marine structures by preventing the corrosion of metals higher up the galvanic scale through their preferential breakdown. The dissolution of anodes directly inputs component metals into local receiving waters, with variable rates of dissolution evident in coastal and estuarine environments. With recent changes to the Environmental Quality Standard (EQS), the load for zinc in estuaries such as the Hamble, UK, which has a large amount of recreational craft, now exceeds the zinc standard of 7...
July 25, 2017: Environmental Science and Pollution Research International
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