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Piperine

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https://www.readbyqxmd.com/read/29772289/nose-to-brain-drug-delivery-an-update-on-clinical-challenges-and-progress-towards-approval-of-anti-alzheimer-drugs
#1
REVIEW
Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G Antimisiaris, Mahavir Chougule, Sunday A Shoyele, Amit Alexander
According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the year 2017 itself, the cost of AD treatment in the USA has been reported to rise to $259 billion. This statistic shows the severity of the disease in the USA which is very much similar across the globe. On the other hand, the treatment remains limited to a few conventional oral medications (approved by FDA). These are mainly acting superficially from mild to the moderate AD...
May 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29751738/transcriptomic-and-metabolomic-analyses-reveal-that-bacteria-promote-plant-defense-during-infection-of-soybean-cyst-nematode-in-soybean
#2
Wenshu Kang, Xiaofeng Zhu, Yuanyuan Wang, Lijie Chen, Yuxi Duan
BACKGROUND: Soybean cyst nematode (SCN) is the most devastating pathogen of soybean. Our previous study showed that the plant growth-promoting rhizobacterium Bacillus simplex strain Sneb545 promotes soybean resistance to SCN. Here, we conducted a combined metabolomic and transcriptomic analysis to gain information regarding the biological mechanism of defence enhancement against SCN in Sneb545-treated soybean. To this end, we compared the transcriptome and metabolome of Sneb545-treated and non-treated soybeans under SCN infection...
May 11, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29718714/development-and-evaluation-of-a-novel-drug-delivery-soluplus%C3%A2-tpgs-mixed-micelle-loaded-with-piperine-in-vitro-and-in-vivo
#3
Yingying Ding, Changyuan Wang, Yutong Wang, Youwei Xu, Jing Zhao, Meng Gao, Yanfang Ding, Jinyong Peng, Lei Li
BACKGROUND: Although piperine can inhibit cells of tumors, the poor water solubility restricted its clinical application. This paper aimed to develop mixed micelles based on Soluplus® and TPGS, to improve the aqueous solubility and anti-cancer effect. METHODS: Piperine -loaded mixed micelles were prepared using a thin- film hydration method, and their physicochemical properties were characterized. The cellular uptake of the micelles was confirmed by confocal laser scanning microscopy in A549 lung cancer cells and HepG2 liver cancer cells...
May 2, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29717031/piperine-functions-as-a-tumor-suppressor-for-human-ovarian-tumor-growth-via-activation-of-jnk-p38-mapk-mediated-intrinsic-apoptotic-pathway
#4
Lihui Si, Ruiqi Yang, Ruixin Lin, Shuli Yang
Piperine, a kind of natural alkaloid found in the fruit of black (Piper nigrum Linn) and long (Piper longum Linn), has shown antitumor activities toward various cancer cell lines. However, the antitumor effects of piperine on ovarian cancer and the underlying mechanism are not fully elucidated. Our result showed that piperine reduced the cell viability of A2780 cells in a concentration and time-dependent manner, but has not any effect on normal ovarian cells. Flow cytometric analysis revealed that piperine suppressed cells proliferation via induction of apoptosis, which was followed by release of mitochondrial cytochrome c to cytosol, activation of caspase-3, and -9, as well as cleaved PARP...
May 1, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29714135/natural-alkaloids-intervening-the-insulin-pathway-new-hopes-for-anti-diabetic-agents
#5
Maria-Ioanna Christodoulou, Job Tchoumtchoua, Alexios-Leandros Skaltsounis, Andreas Scorilas, Maria Halabalaki
BACKGROUND: Accumulating experimental data support the capacity of natural compounds to intervene in complicated molecular pathways underlying the pathogenesis of certain human morbidities. Among them, diabetes is now a world's epidemic associated with increased risk of death; thus, the detection of novel anti-diabetic agents and/or adjuvants is of vital importance. Alkaloids represent a diverse group of natural products with a range of therapeutic properties; during the last 20 years published research on their anti-diabetic capacity has been tremendously increased...
April 30, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29710511/piperine-alleviates-lipopolysaccharide-induced-inflammatory-injury-by-down-regulating-microrna-127-in-murine-chondrogenic-atdc5-cells
#6
Chunfeng Ren, Zhiyuan Liang
BACKGROUND: This study aimed to investigate whether piperine has anti-inflammatory activities in lipopolysaccharide (LPS)-induced inflammatory injury of murine chondrogenic ATDC5 cells and to explore the potential mechanisms. METHODS: ATDC5 cells were pretreated with piperine and then stimulated by LPS for 12 h. Cell Counting Kit-8 (CCK-8) and flow cytometry were used to assess cell viability and apoptosis, respectively. qRT-PCR, enzyme-linked immuno sorbent assay (ELISA) and western blotting were used to detect the expression levels of inflammatory cytokines, microRNA-127 (miR-127) and MyD88, as well as key factors involved in nuclear factor kappa B (NF-κB) and p38-mitogen activated protein kinase (p38MAPK) signaling pathways, respectively...
April 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29683271/piperine-promotes-glucose-uptake-through-ros-dependent-activation-of-the-camkk-ampk-signaling-pathway-in-skeletal-muscle
#7
Ayumi Maeda, Takeshi Shirao, Daishi Shirasaya, Yasukiyo Yoshioka, Yoko Yamashita, Mitsugu Akagawa, Hitoshi Ashida
SCOPE: The prevalence of type 2 diabetes mellitus (T2DM) is increasing yearly worldwide. Glycemic control is the basis for the treatment of T2DM, as it can prevent the progress of associated complications. Spices possess various health beneficial effects on humans. The aim of this study was to search for spices that can promote glucose uptake and to elucidate the underlying molecular mechanism(s). METHODS AND RESULTS: Among 24 spice extracts, the extracts from black and white pepper significantly increased glucose uptake in L6 myotubes...
April 23, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29643806/diverged-effects-of-piperine-on-testicular-development-stimulating-leydig-cell-development-but-inhibiting-spermatogenesis-in-rats
#8
Xianwu Chen, Fei Ge, Jianpeng Liu, Suhao Bao, Yong Chen, Dongli Li, Yong Li, Tongliang Huang, Xiaofang Chen, Qiqi Zhu, Qingquan Lian, Ren-Shan Ge
Background: Piperine is the primary pungent alkaloid isolated from the fruit of black peppercorns. Piperine is used frequently in dietary supplements and traditional medicines. The objective of the present study was to investigate the effects of piperine on the testis development in the pubertal rat. Methods: Piperine (0 or 5 or 10 mg/kg) was gavaged to 35-day-old male Sprague-Dawley rats for 30 days. Serum levels of testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29625099/sinergism-between-alkaloids-piperine-and-capsaicin-with-meglumine-antimoniate-against-leishmania-infantum
#9
Francisco Marcelo Vieira-Araújo, Fernanda Cristina Macedo Rondon, Ícaro Gusmão Pinto Vieira, Francisca Noelia Pereira Mendes, José Caludio Carneiro de Freitas, Selene Maia de Morais
The primary choice of drugs to treat Leishmaniasis are the pentavalent antimony-based compounds, nevertheless these drugs presented undesirable side effects. However, safe natural compounds could be used in combination with these drugs to enhance their activity. The aim of this study was to evaluate the sinergism of capsaicin and piperine, isolated from Capsicum frutescens and Piper nigrum, respectively, in combination with meglumine antimoniate against Leishmania infantum promastigote and amastigote forms...
April 3, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29606743/flavor-characteristics-and-antioxidant-capacities-of-hihatsumodoki-piper-retrofractum-vahl-fresh-fruit-at-three-edible-maturity-stages
#10
Makoto Takahashi, Naoto Hirose, Suguru Ohno, Mika Arakaki, Koji Wada
To determine the effect of maturity stage on the food attributes of hihatsumodoki ( Piper retrofractum Vahl) fresh fruit, the flavor characteristics and antioxidant capacities were investigated at green (GM), orange (OM), and red maturity (RM) stages. Total organic acids, total free amino acids (FAA), and piperine decreased with increasing fruit maturation, reaching minima at the RM stage. Conversely, total sugars and the FAA that contribute to both umami and sweetness were the highest RM stage. Principal component analysis revealed that the volatile composition of the fruit at the GM stage was clearly different from that at the other stages...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29597041/development-of-core-shell-nanocarrier-system-for-augmenting-piperine-cytotoxic-activity-against-human-brain-cancer-cell-line
#11
Abanoub S Sedeky, Islam A Khalil, Amr Hefnawy, Ibrahim M El-Sherbiny
Brain tumor has a low prognosis with only 15% survival rate (5 years after diagnosis). Many of the current therapeutics have limited activity due to their inability to cross the blood brain barrier which retards drug accumulation in tumor site and causes drug resistance. Piperine, a phytochemical drug with poor solubility, could be an alternative to current therapeutics after evading its solubility and permeability limitations. Piperine micellization was optimized to improve drug solubility. Positively charged trimethyl-chitosan was synthesized then electrostatically adsorbed onto piperine nanomicelles forming core-shell nanoparticles...
March 26, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29556123/curcumin-and-piperine-loaded-zein-chitosan-nanoparticles-development-and-in-vitro-characterisation
#12
Yücel Baspinar, Mehmet Üstündas, Oguz Bayraktar, Canfeza Sezgin
Curcumin as the active compound of turmeric has antioxidative, antiinflammatory, antimicrobial and anticancer properties among others. However, its disadvantageous properties like low solubility, poor bioavailability and rapid degradation under neutral or alkaline pH conditions or when exposed to light limit its clinical application. These problems can be solved by a smart combination of using a natural enhancer like piperine and preparing nanoparticles by a proper method like electrospray. Due to these facts it was aimed in this study to develop curcumin and piperine loaded zein-chitosan nanoparticles step by step...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29547277/high-throughput-effect-directed-analysis-using-downscaled-in-vitro-reporter-gene-assays-to-identify-endocrine-disruptors-in-surface-water
#13
Nick Zwart, Shan Li Nio, Corine J Houtman, Jacob De Boer, Jeroen Kool, Timo Hamers, Marja H Lamoree
Effect-Directed Analysis (EDA) is a commonly used approach for effect-based identification of endocrine disruptive chemicals in complex (environmental) mixtures. For routine toxicity assessment of e.g. water samples however, current EDA approaches are considered time consuming and laborious. We achieved faster EDA and identification, by downscaling of sensitive cell-based hormone reporter gene assays and increasing fractionation resolution to allow testing of smaller fractions with reduced complexity. The high-resolution EDA approach is demonstrated by analysis of four environmental passive sampler extracts...
March 16, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29543522/diet-therapy-for-cancer-prevention-and-treatment-based-on-traditional-persian-medicine
#14
Behjat Javadi
Cancer is the second leading cause of death with profound socio-economic consequences worldwide. Growing evidence suggests the crucial role of diet on cancer prevention and treatment. In Traditional Persian Medicine (TPM) there is a major focus on contribution of special diet and foods to cancer management. In the present article, the cytotoxic and antitumor activities of several food items including plants and animal products recommended by TPM as anticancer agents are discussed. Strong evidence supports the anticancer effects of beetroot (Beta vulgris) and its major compound betanin, cinnamon and cinnamaldehyde, barley (H...
April 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29537855/the-effect-of-piperine-pro-nano-lipospheres-on-direct-intestinal-phase-ii-metabolism-the-raloxifene-paradigm-of-enhanced-oral-bioavailability
#15
Dvora Izgelov, Irina Cherniakov, Gefen Aldouby Bier, Abraham J Domb, Amnon Hoffman
In recent years, Phase II metabolism, as a first pass metabolism process occurring to the parent drug, is gaining more and more attention. This is due to its acknowledged significance in drug development as well as drug-drug interactions. However, the predominant role of Phase I metabolism has always overshadowed Phase II metabolism, resulting in insufficient data regarding its mechanisms. In this paper, we investigate the effect of an advanced lipid based drug delivery system on Phase II metabolism at the intestinal level of the enterocytes monolayer...
March 14, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29527430/green-synthesis-of-fluorescent-carbon-dots-from-spices-for-in-vitro-imaging-and-tumour-cell-growth-inhibition
#16
Nagamalai Vasimalai, Vânia Vilas-Boas, Juan Gallo, María de Fátima Cerqueira, Mario Menéndez-Miranda, José Manuel Costa-Fernández, Lorena Diéguez, Begoña Espiña, María Teresa Fernández-Argüelles
Carbon dots have demonstrated great potential as luminescent nanoparticles in bioapplications. Although such nanoparticles appear to exhibit low toxicity compared to other metal luminescent nanomaterials, today we know that the toxicity of carbon dots (C-dots) strongly depends on the protocol of fabrication. In this work, aqueous fluorescent C-dots have been synthesized from cinnamon, red chilli, turmeric and black pepper, by a one-pot green hydrothermal method. The synthesized C-dots were firstly characterized by means of UV-vis, fluorescence, Fourier transform infrared and Raman spectroscopy, dynamic light scattering and transmission electron microscopy...
2018: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29498663/capsaicin-and-piperine-can-overcome-multidrug-resistance-in-cancer-cells-to-doxorubicin
#17
Hanmei Li, Sonja Krstin, Shihui Wang, Michael Wink
BACKGROUND: Multidrug resistance (MDR) can develop in cancer cells after treatment with anticancer drugs, mainly due to the overexpression of the ATP-binding cassette (ABC) transporters. We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum , respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters. METHODS: The MTT assay was first used to determine the cytotoxicity of doxorubicin, the alkaloids, and digitonin alone, and then their combinations...
March 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29497610/cancer-chemoprevention-and-piperine-molecular-mechanisms-and-therapeutic-opportunities
#18
REVIEW
Rafiq A Rather, Madhulika Bhagat
Cancer is a genetic disease characterized by unregulated growth and dissemination of malignantly transformed neoplastic cells. The process of cancer development goes through several stages of biochemical and genetic alterations in a target cell. Several dietary alkaloids have been found to inhibit the molecular events and signaling pathways associated with various stages of cancer development and therefore are useful in cancer chemoprevention. Cancer chemoprevention has long been recognized as an important prophylactic strategy to reduce the burden of cancer on health care system...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29488612/piperine-depresses-the-migration-progression-via-downregulating-the-akt-mtor-mmp%C3%A2-9-signaling-pathway-in-du145-cells
#19
Yuan Zeng, Ying Yang
Piperine, an alkaloid derived from natural products, has been demonstrated to exert antitumor activities in vivo and in vitro. However, its anti‑tumor effect has not yet been illustrated in the prostate cancer (PCa) metastatic process. Thus, the present study explored the influence of piperine on PCa and the underlying molecular mechanism. Cell migration was detected via the Transwell chamber model. Total protein was identified by western blot analysis. The data revealed that piperine markedly repressed cell proliferation and migration, and induced apoptosis in PCa DU145...
May 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29458218/effects-of-curcuminoids-plus-piperine-on-glycemic-hepatic-and-inflammatory-biomarkers-in-patients-with-type-2-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-trial
#20
Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Luis E Simental-Mendía, Muhammed Majeed, Amirhossein Sahebkar
INTRODUCTION: Curcuminoids have been shown to reduce glycemia and related complications in diabetes. In the present study, we evaluated the impact of curcuminoids plus piperine administration on glycemic, hepatic and inflammatory biomarkers in type 2 diabetes (T2D) patients. METHODS: T2D patients aged 18-65 years were enrolled in a randomized double-blind placebo-controlled trial and randomly allocated to standard-of-care treatment and dietary advises plus either curcuminoids (daily dose of 500 mg/day co-administered with piperine 5 mg/day) or placebo for a period of 3 months...
February 19, 2018: Drug Research
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