keyword
MENU ▼
Read by QxMD icon Read
search

Piperine

keyword
https://www.readbyqxmd.com/read/28330809/piperine-attenuates-pathological-cardiac-fibrosis-via-ppar-%C3%AE-akt-pathways
#1
Zhen-Guo Ma, Yu-Pei Yuan, Xin Zhang, Si-Chi Xu, Sha-Sha Wang, Qi-Zhu Tang
Mitogen-activated protein kinases (MAPKs) and AMP-activated protein kinase α (AMPKα) play critical roles in the process of cardiac hypertrophy. Previous studies have demonstrated that piperine activates AMPKα and reduces the phosphorylation of extracellular signal-regulated kinase (ERK). However, the effect of piperine on cardiac hypertrophy remains completely unknown. Here, we show that piperine-treated mice had similar hypertrophic responses as mice treated with vehicle but exhibited significantly attenuated cardiac fibrosis after pressure overload or isoprenaline (ISO) injection...
March 14, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28326461/toxicity-and-detoxification-mechanism-of-black-pepper-and-its-major-constituent-in-controlling-rhynchophorus-ferrugineus-olivier-curculionidae-coleoptera
#2
A Hussain, M Rizwan-Ul-Haq, H Al-Ayedh, A M Aljabr
The survival, feeding response, and detoxification mechanism of Rhynchophorus ferrugineus Olivier, a key pest responsible for destruction of date palm, was examined with different extracts of Piper nigrum and its major constituent (piperine) identified by GC-MS. In the present study, toxicity of different extracts of black pepper was evaluated by incorporating diffferent doses of extracts into the artificial diet of red palm weevil larvae. All extracts showed dose-dependent insecticidal activity to the tested eighth-instar red palm weevil larvae...
March 21, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28314475/pharmacokinetic-based-study-on-lagged-stimulation-of-curcumae-longae-rhizoma-piper-nigrum-couplet-in-their-main-active-components-metabolism-using-uplc-ms-ms
#3
Zhao Chen, Dongmei Sun, Xiaoli Bi, Xiaohui Zeng, Wenhui Luo, Dake Cai, Qiaohuang Zeng, Aili Xu
BACKGROUND: Curcumae Longae Rhizoma is one of the commonly used traditional Chinese medicines, which has multiple biological activities such as relieving stagnation and stasis, pain alleviation, curing amenorrhea and wounds. However, its main active component-curcumin has poor absorption and very fast metabolism in body. To solve this problem, Piper nigrum was introduced for its ability to strengthen bioavailability of other compounds. PURPOSE: In most cases of TCM couplets, all ingredients were prepared and taken simultaneously, which in our opinion did not take full advantage of their interactions...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28254575/in-vivo-cough-suppressive-activity-of-pectic-polysaccharide-with-arabinogalactan-type-ii-side-chains-of-piper-nigrum-fruits-and-its-synergistic-effect-with-piperine
#4
Sadhana Khawas, Gabriela Nosáľová, Sujay Kumar Majee, Kanika Ghosh, Washim Raja, Veronika Sivová, Bimalendu Ray
Piper nigrum L. fruits are not only a prized spice, but also highly valued therapeutic agent that heals many ailments including asthma, cold and respiratory problems. Herein, we have investigated structural features and in vivo antitussive activity of three fractions isolated from Piper nigrum fruits. The water extract (PN-WE) upon fractionation with EtOH yielded two fractions: a soluble fraction (PN-eSf) and a precipitated (PN-ePf) one. The existence of a pectic polysaccharide with arabinogalactan type II side chains (147kDa) in PN-ePf and piperine in PN-eSf were revealed...
February 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28224643/endophytic-phomopsis-sp-colonization-in-oryza-sativa-was-found-to-result-in-plant-growth-promotion-and-piperine-production
#5
Chithra S, Jasim B, Jyothis Mathew, Radhakrishnan E K
Endophytic fungi have been reported to have the acquired ability to synthesize host plant specific medicinal natural products. Many fungi with such properties have been characterized and optimized for the conditions which favor maximal production of desired products. However, the inherent plant colonization property of promising endophytic fungi is least studied. Exploiting the transgenome functioning of these fungi have immense applications to add beneficial features to non-host plants. In the present study, endophytic fungus Phomopsis sp...
February 22, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28224392/investigation-of-need-of-natural-bioenhancer-for-a-metabolism-susceptible-drug-raloxifene-in-a-designed-self-emulsifying-drug-delivery-system
#6
Poonam Singh Thakur, Narinder Singh, Abhay T Sangamwar, Arvind Kumar Bansal
Bioenhancers can increase the bioavailability of metabolism susceptible drugs. The present study was designed to understand the impact of bioenhancer on permeability and bioavailability of a biopharmaceutical drug disposition classification system (BDDCS) class II drug raloxifene (RLX). RLX undergoes extensive first pass metabolism by UGT enzymes in gastrointestinal tract (GIT) and has an oral bioavailability of about 2%. Self-emulsifying drug delivery system (SEDDS) of RLX was developed using a designed approach and this formulation was loaded with reported bioenhancers: quercetin and piperine...
February 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28185326/alkaloids-from-piper-nigrum-exhibit-antiinflammatory-activity-via-activating-the-nrf2-ho-1-pathway
#7
Quynh Mai Thi Ngo, Phuong Thao Tran, Manh Hung Tran, Jeong Ah Kim, Seong Soo Rho, Chi-Hwan Lim, Jin-Cheol Kim, Mi Hee Woo, Jae Sui Choi, Jeong-Hyung Lee, Byung Sun Min
In the present study, ten alkaloids, namely chabamide (1), pellitorine (2), retrofractamide A (3), pyrroperine (4), isopiperolein B (5), piperamide C9:1 (8E) (6), 6,7-dehydrobrachyamide B (7), 4,5-dihydropiperine (8), dehydropipernonaline (9), and piperine (10), were isolated from the fruits of Piper nigrum. Among these, chabamide (1), pellitorine (2), retrofractamide A (3), isopiperolein B (5), and 6,7-dehydrobrachyamide B (7) exhibited significant inhibitory activity on lipopolysaccharide-induced nitric oxide (NO) production in RAW264...
February 10, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28166943/cold-adaptive-thermogenesis-following-consumption-of-certain-pungent-spice-principles-a-validation-study
#8
Chaitanya Pandit, K R Anilakumar
Identifying a means to activate or potentiate thermogenic mechanisms through ingestion of dietary compounds have important implications in cold endurance and survival. Although many reports discuss the thermogenic potential of spices, it is surprising that none of the studies verify whether consumption of spices can improve cold endurance. In this study, we have attempted to evaluate if ingestion of certain spices can activate heat-generating mechanisms in the body such that a fall in. core body temperature (CBT) can be delayed or prevented when faced with a cold challenge...
February 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28165813/piperine-ameliorates-collagenase-induced-achilles-tendon-injury-in-the-rat
#9
Fengyan Gong, Lifeng Cui, Xiaona Zhang, Xiangbo Zhan, Xu Gong, Yan Wen
Tendinopathy is a common clinical pathology found in athletes and workers with mixed treatment results. Piperine, a major alkaloid found in the black and long pepper, has been demonstrated to have variety of pharmacological properties such as analgesic and anti-inflammatory effects. The present study was designed to investigate the effects of piperine on collagenase-induced Achilles tendon injury. Rats were intratendineously injected with collagenase in the right Achilles tendon, followed by intragastrical administration of piperine (100 mg/kg)...
February 6, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28161984/formulation-of-piperine-solid-lipid-nanoparticles-sln-for-treatment-of-rheumatoid-arthritis
#10
M R Bhalekar, A R Madgulkar, Puja S Desale, Gyce Marium
The purpose of this work was to formulate piperine solid lipid nanoparticle (SLN) dispersion to exploit its efficacy orally and topically. Piperine-SLN were prepared by melt emulsification method and formula was optimized by the application of 3(2) factorial design. The nanoparticulate dispersion was evaluated for particle size, entrapment efficiency (EE) and zeta potential(ZP). Optimized batch (128.80 nm average size, 78.71% EE and -23.34 Mv Zeta Potential) was characterized for differential scanning calorimetry (DSC), X-ray diffraction(XRD) which revealed amorphous nature of piperine in SLN...
February 6, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28160856/vasculoprotective-and-vasodilatation-effects-of-herbal-formula-sahatsatara-and-piperine-in-spontaneously-hypertensive-rats
#11
Suksalin Booranasubkajorn, Sukit Huabprasert, Jantanee Wattanarangsan, Pruksa Chotitham, Pinpilai Jutasompakorn, Tawee Laohapand, Pravit Akarasereenont, Pinpat Tripatara
BACKGROUND: The herbal formula (Sahatsatara, STF), the Thai traditional poly-herbal recipe, has been used for treatment of muscle pain, anti-flatulence and numbness on hands and feet, with the caution when used in hypertensive patients. However, there is no scientific evidence to prove its effects on cardiovascular system. Piperine is the proposed major active compound in STF. It is shown to have antihypertensive effect in the L-NAME-induced endothelial dysfunction rats. PURPOSE: This study investigated the pharmacokinetics, mechanism of action, as well as the hemodynamic and vasoactive effect and toxicity of STF and piperine using spontaneously hypertensive rats (SHR) and normal Wistar rats (NWR)...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28123572/solid-lipid-nanoparticles-with-tpgs-and-brij-78-a-co-delivery-vehicle-of-curcumin-and-piperine-for-reversing-p-glycoprotein-mediated-multidrug-resistance-in-vitro
#12
Jingling Tang, Hongyu Ji, Jinmei Ren, Mengting Li, Nannan Zheng, Linhua Wu
Multidrug resistance (MDR) is a main clinical hurdle for chemotherapy of cancer, and overexpression of P-glycoprotein (P-gp) is a key factor. In the present study, a new co-delivery system for reversing MDR was designed and developed. The system was composed of curcumin (Cur) and piperine (Pip) encapsulated in solid lipid nanoparticles (SLNs) with tocopheryl polyethylene glycol succinate (TPGS) and Brij 78 [(Cur+Pip)-SLNs]. TPGS and Brij 78 could sensitize MDR tumors by inhibiting the P-gp drug efflux system...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28117414/piperine-regulates-ucp1-through-the-ampk-pathway-by-generating-intracellular-lactate-production-in-muscle-cells
#13
Nami Kim, Miso Nam, Mi Sun Kang, Jung Ok Lee, Yong Woo Lee, Geum-Sook Hwang, Hyeon Soo Kim
This study characterizes the human metabolic response to piperine, a curcumin extract, and the details of its underlying molecular mechanism. Using (1)H-NMR-based metabolome analysis, we showed the metabolic effect of piperine on skeletal muscle and found that piperine increased the level of intracellular lactate, an important metabolic intermediate that controls expression of several genes involved in mitochondrial activity. Piperine also induced the phosphorylation of AMP-activated protein kinase (AMPK) and its downstream target, acetyl-CoA carboxylase (ACC), while additionally stimulating glucose uptake in an AMPK dependent manner...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102026/piperine-a-pungent-alkaloid-from-black-pepper-inhibits-b-lymphocyte-activation-and-effector-functions
#14
David A Soutar, Carolyn D Doucette, Robert S Liwski, David W Hoskin
Piperine has several well-documented anti-inflammatory properties; however, little is known regarding its effect on humoral immunity. In this study, we describe the immunosuppressive effect of piperine on B lymphocytes, which are integral to the humoral immune response. Mouse B cells were cultured in the absence or presence of non-cytotoxic concentrations (25, 50, and 100 μM) of piperine during T-dependent or T-independent stimulation. Piperine inhibited B cell proliferation by causing G0/G1 phase cell cycle arrest in association with reduced expression of cyclin D2 and D3...
January 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28088738/piperine-modulates-isoproterenol-induced-myocardial-ischemia-through-antioxidant-and-anti-dyslipidemic-effect-in-male-wistar-rats
#15
Velumani Dhivya, Lohanathan Bharathi Priya, Hilda T Chirayil, Swamiappan Sathiskumar, Chih-Yang Huang, Viswanadha Vijaya Padma
Myocardial infarction due to ischemia accounts for majority of deaths among cardiovascular disorders. Isoproterenol (ISO) induced myocardial infarction and the protection offered by piperine was investigated in the present report. Lipid profile analysis by determining the levels of cholesterol, phospholipids, triglycerides and lipoproteins in serum and heart tissues showed anti-dyslipidemic action of piperine against ISO induced myocardial injury by modulating the ISO induced altered lipid profiles, maintaining to near control values...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28068976/il-1%C3%AE-induced-modulation-of-gene-expression-profile-in-human-dermal-fibroblasts-the-effects-of-thai-herbal-sahatsatara-formula-piperine-and-gallic-acid-possessing-antioxidant-properties
#16
Onusa Thamsermsang, Pravit Akarasereenont, Tawee Laohapand, Uraiwan Panich
BACKGROUND: Pain is the main symptom of most musculoskeletal disorders and can be caused by inflammation in association with oxidative stress. Thai herbal Sahatsatara formula (STF), a polyherbal formula, has been traditionally used for relieving muscle pain and limb numbness. This study aimed to investigate biologically active compounds of STF and its pharmacological effects related to antioxidant and anti-inflammatory activities. METHODS: The identification of possibly active compounds of STF was performed by high performance liquid chromatography (HPLC)...
January 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28065397/sensory-active-piperine-analogues-from-macropiper-excelsum-and-their-effects-on-intestinal-nutrient-uptake-in-caco-2%C3%A2-cells
#17
Katja Obst, Barbara Lieder, Katharina V Reichelt, Michael Backes, Susanne Paetz, Katrin Geißler, Gerhard Krammer, Veronika Somoza, Jakob P Ley, Karl-Heinz Engel
The phytochemical profile of Macropiper excelsum (G.Forst.) Miq. subsp. excelsum (Piperaceae), a shrub which is widespread in New Zealand, was investigated by LC-MS-guided isolation and characterization via HR-ESI-TOF-MS and NMR spectroscopy. The isolated compounds were sensorily evaluated to identify their contribution to the overall taste of the crude extract with sweet, bitter, herbal and trigeminal impressions. Besides the known non-volatile Macropiper compounds, the lignans (+)-diayangambin and (+)-excelsin, four further excelsin isomers, (+)-diasesartemin, (+)-sesartemin, (+)-episesartemin A and B were newly characterized...
March 2017: Phytochemistry
https://www.readbyqxmd.com/read/28018704/synthesis-and-characterization-of-molecular-imprinting-polymer-microspheres-of-piperine-extraction-of-piperine-from-spiked-urine
#18
Rachel Marcella Roland, Showkat Ahmad Bhawani
Molecularly imprinted polymer (MIP) microspheres for Piperine were synthesized by precipitation polymerization with a noncovalent approach. In this research Piperine was used as a template, acrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and 2,2'-azobisisobutyronitrile (AIBN) as an initiator and acetonitrile as a solvent. The imprinted and nonimprinted polymer particles were characterized by using Fourier transform infrared spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM)...
2016: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28001214/a-biodegradable-device-for-the-controlled-release-of-piper-nigrum-piperaceae-standardized-extract-to-control-aedes-aegypti-diptera-culicidae-larvae
#19
Kauê Muller Custódio, Joice Guilherme de Oliveira, Diego Moterle, Karine Modolon Zepon, Josiane Somariva Prophiro, Luiz Alberto Kanis
INTRODUCTION: The significant increase in dengue, Zika, and chikungunya and the resistance of the Aedes aegypti mosquito to major insecticides emphasize the importance of studying alternatives to control this vector. The aim of this study was to develop a controlled-release device containing Piper nigrum extract and to study its larvicidal activity against Aedes aegypti. METHODS: Piper nigrum extract was produced by maceration, standardized in piperine, and incorporated into cotton threads, which were inserted into hydrogel cylinders manufactured by the extrusion of carrageenan and carob...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27995955/evidences-for-piperine-inhibiting-cancer-by-targeting-human-g-quadruplex-dna-sequences
#20
Arpita Tawani, Ayeman Amanullah, Amit Mishra, Amit Kumar
Piperine, a naturally occurring alkaloid, is well known as anti-oxidant, anti-mutagenic, anti-tumor and anti-proliferative agent. Piperine exerts such pharmacological activities by binding or interacting with various cellular targets. Recently, the first report for Piperine interaction with duplex DNA has been published last year but its interaction with G-quadruplex structures has not been studied yet. Herein, we report for the first time the interaction of Piperine with various DNA G-quadruplex structures...
December 20, 2016: Scientific Reports
keyword
keyword
13629
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"