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https://www.readbyqxmd.com/read/29688272/cellular-plasticity-in-the-adult-murine-piriform-cortex-continuous-maturation-of-dormant-precursors-into-excitatory-neurons
#1
Peter Rotheneichner, Maria Belles, Bruno Benedetti, Richard König, Dominik Dannehl, Christina Kreutzer, Pia Zaunmair, Maren Engelhardt, Ludwig Aigner, Juan Nacher, Sebastien Couillard-Despres
Neurogenesis in the healthy adult murine brain is based on proliferation and integration of stem/progenitor cells and is thought to be restricted to 2 neurogenic niches: the subventricular zone and the dentate gyrus. Intriguingly, cells expressing the immature neuronal marker doublecortin (DCX) and the polysialylated-neural cell adhesion molecule reside in layer II of the piriform cortex. Apparently, these cells progressively disappear along the course of ageing, while their fate and function remain unclear...
April 21, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29686048/fear-memory-recall-potentiates-opiate-reward-sensitivity-through-dissociable-dopamine-d1-vs-d4-receptor-dependent-memory-mechanisms-in-the-prefrontal-cortex
#2
Jing Jing Li, Hanna Szkudlarek, Justine Renard, Roger Hudson, Walter Rushlow, Steven R Laviolette
Disturbances in prefrontal cortical (PFC) dopamine (DA) transmission are well-established features of psychiatric disorders involving pathological memory processing, such as post-traumatic stress disorder (PTSD) and opioid addiction. Transmission through PFC DA D4 receptors (D4R) has been shown to potentiate the emotional salience of normally non-salient emotional memories whereas transmission through PFC DA D1 receptors (D1R) has been demonstrated to selectively block recall of reward or aversion-related associative memories...
April 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29682889/fkbp12-6-protects-heart-from-angii-induced-hypertrophy-through-inhibiting-ca-2-calmodulin-mediated-signalling-pathways-in-vivo-and-in-vitro
#3
Yun-Fei Xiao, Zhi-Xiong Zeng, Xiao-Hui Guan, Ling-Fang Wang, Chan-Juan Wang, Huidong Shi, Weinian Shou, Ke-Yu Deng, Hong-Bo Xin
We previously observed that disruption of FK506-binding protein 12.6 (FKBP12.6) gene resulted in cardiac hypertrophy in male mice. Studies showed that overexpression of FKBP12.6 attenuated thoracic aortic constriction (TAC)-induced cardiac hypertrophy in mice, whereas the adenovirus-mediated overexpression of FKBP12.6 induced hypertrophy and apoptosis in cultured neonatal cardiomyocytes, indicating that the role of FKBP12.6 in cardiac hypertrophy is still controversial. In this study, we aimed to investigate the roles and mechanisms of FKBP12...
April 22, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29673297/characterization-of-copk02-a-ca-2-calmodulin-dependent-protein-kinase-in-mushroom-coprinopsis-cinerea
#4
Masashi Yamashita, Noriyuki Sueyoshi, Hiroki Yamada, Syouichi Katayama, Yukako Senga, Yasuhiro Takenaka, Atsuhiko Ishida, Isamu Kameshita, Yasushi Shigeri
We surveyed genome sequences from the basidiomycetous mushroom Coprinopsis cinerea and isolated a cDNA homologous to CMKA, a calmodulin-dependent protein kinase (CaMK) in Aspergillus nidulans. We designated this sequence, encoding 580 amino acids with a molecular weight of 63,987, as CoPK02. CoPK02 possessed twelve subdomains specific to protein kinases and exhibited 43, 35, 40% identity with rat CaMKI, CaMKII, CaMKIV, respectively, and 40% identity with CoPK12, one of the CaMK orthologs in C. cinerea. CoPK02 showed significant autophosphorylation activity and phosphorylated exogenous proteins in the presence of Ca2+ /CaM...
April 20, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29669320/camkii-potentiates-store-operated-ca2-entry-through-enhancing-stim1-aggregation-and-interaction-with-orai1
#5
Shu Li, Jingyi Xue, Zhipeng Sun, Tiantian Liu, Lane Zhang, Limin Wang, Hongjie You, Zheng Fan, Yuanyuan Zheng, Dali Luo
BACKGROUND/AIMS: Upon Ca2+ store depletion, stromal interaction molecule 1 (STIM1) oligomerizes, redistributes near plasmalemma to interact with Ca2+ selective channel-forming subunit (Orai1) and initiates store-operated Ca2+ entry (SOCE). Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a regulator of SOCE, but how CaMKII regulates SOCE remains obscure. METHODS: Using Fura2, confocal microscopy, co-immunoprecipitation, specific blocker and overexpression/knockdown approaches, we evaluated STIM1 aggregation and its interaction with Orai1, and SOCE upon Ca2+ store depletion in thapsigargin (TG) treated HEK293 and HeLa cells...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29668881/hyperactive-ryanodine-receptors-in-human-heart-failure-and-ischemic-cardiomyopathy-reside-outside-of-couplons
#6
Eef Dries, Demetrio J Santiago, Guillaume Gilbert, Ilse Lenaerts, Bert Vandenberk, Chandan K Nagaraju, Daniel M Johnson, Patricia Holemans, H Llewelyn Roderick, Niall Macquaide, Piet Claus, Karin R Sipido
Aims: In ventricular myocytes from humans and large mammals, the transverse and axial tubular system (TATS) network is less extensive than in rodents with consequently a greater proportion of ryanodine receptors (RyRs) not coupled to this membrane system. TATS remodeling in heart failure (HF) and after myocardial infarction (MI) increases the fraction of non-coupled RyR. Here we investigate whether this remodeling alters the activity of coupled and non-coupled RyR sub-populations through changes in local signaling...
April 14, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29661832/kinase-activity-in-the-olfactory-bulb-is-required-for-odor-memory-consolidation
#7
Michelle T Tong, Tae-Young P Kim, Thomas A Cleland
Long-term fear memory formation in the hippocampus and neocortex depends upon brain-derived neurotrophic factor (BDNF) signaling after acquisition. Incremental, appetitive odor discrimination learning is thought to depend substantially on the differentiation of adult-born neurons within the olfactory bulb (OB)-a process that is closely associated with BDNF signaling. We sought to elucidate the role of neurotrophin signaling within the OB on odor memory consolidation. Male mice were trained on odor-reward associative discriminations after bilateral infusion of the kinase inhibitor K252a, or vehicle control, into the OB...
May 2018: Learning & Memory
https://www.readbyqxmd.com/read/29660932/neuroprotective-effects-of-ferruginol-jatrophone-and-junicedric-acid-against-amyloid-%C3%AE-injury-in-hippocampal-neurons
#8
Juan M Zolezzi, Carolina B Lindsay, Felipe G Serrano, Roxana C Ureta, Cristina Theoduloz, Guillermo Schmeda-Hirschmann, Nibaldo C Inestrosa
Soluble amyloid-β (Aβ) oligomers have been recognized as early neurotoxic intermediates with a key role in the synaptic dysfunction observed in Alzheimer's disease (AD). Aβ oligomers block hippocampal long-term potentiation (LTP) and impair rodent spatial memory. Additionally, the presence of Aβ oligomers is associated with imbalanced intracellular calcium levels and apoptosis in neurons. In this context, we evaluated the effects of three diterpenes (ferruginol, jatrophone, and junicedric acid) that are found in medicinal plants and have several forms of biological activity...
April 10, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29628206/odorant-receptor-might-be-related-to-sperm-dna-integrity-in-apis-cerana-cerana
#9
Lina Guo, Huiting Zhao, Bing Xu, Yusuo Jiang
Olfactory receptors (ORs) are important for insects to recognize and discriminate odorants in the environment and are mainly expressed in olfactory and gustatory organs. Little is known about the potential OR functions in non-olfactory tissues. In the present study, we evaluated the possibility of odorant receptors AcerOr1 and AcerOr2 (AcerOr2 is orthologous to the co-receptor) mediating sperm DNA integrity, and the relationship between sperm DNA integrity and semen parameters in Apis cerana cerana. Based on previous findings in mammals, we speculated that the Ca2+ /calmodulin (CaM)/CaM-dependent protein kinase II (CaMKII) signaling pathway might be involved in the regulation of sperm motility in A...
March 31, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29626161/extracellular-atp-activates-hyaluronan-synthase-2-has2-in-epidermal-keratinocytes-via-p2y-2-ca-2-signaling-and-mapk-pathways
#10
Leena Rauhala, Tiina Jokela, Riikka Kärnä, Geneviève Bart, Piia Takabe, Sanna Oikari, Markku I Tammi, Sanna Pasonen-Seppänen, Raija H Tammi
Extracellular nucleotides are used as signaling molecules by several cell types. In epidermis, their release is triggered by insults such as ultraviolet radiation, barrier disruption and wounding and by specific nerve terminals firing. Increased synthesis of hyaluronan, a ubiquitous extracellular matrix glycosaminoglycan, also occurs in response to stress, leading to the attractive hypothesis that nucleotide signaling and hyaluronan synthesis could also be linked. In HaCaT keratinocytes ATP caused a rapid and strong but transient activation of hyaluronan synthase 2 ( HAS2 ) expression via PKC-, CaMKII-, MAPK- and CREB-dependent pathways by activating the purinergic P2Y2 receptor...
April 6, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29620520/synapse-specific-and-compartmentalized-expression-of-presynaptic-homeostatic-potentiation
#11
Xiling Li, Pragya Goel, Catherine Chen, Varun Angajala, Xun Chen, Dion K Dickman
Postsynaptic compartments can be specifically modulated during various forms of synaptic plasticity, but it is unclear whether this precision is shared at presynaptic terminals. Presynaptic Homeostatic Plasticity (PHP) stabilizes neurotransmission at the Drosophila neuromuscular junction, where a retrograde enhancement of presynaptic neurotransmitter release compensates for diminished postsynaptic receptor functionality. To test the specificity of PHP induction and expression, we have developed a genetic manipulation to reduce postsynaptic receptor expression at one of the two muscles innervated by a single motor neuron...
April 5, 2018: ELife
https://www.readbyqxmd.com/read/29617678/increased-asics-expression-via-the-camkii-creb-pathway-in-a-novel-mouse-model-of-trigeminal-pain
#12
Yan Wang, Xiujuan Fu, Lifang Huang, Xi Wang, Zuneng Lu, Fan Zhu, Zheman Xiao
BACKGROUND/AIMS: Migraine is a disabling condition that severely impacts socioeconomic function and quality of life. The focus of this study was to develop a mouse model of trigeminal pain that mimics migraine. METHODS: After undergoing dural cannulation surgery, mice were treated with repeated dural doses of an acidic solution to induce trigeminal pain. RESULTS: The method elicited intermittent, head-directed wiping and scratching as well as the expression of both the c-FOS gene in the spinal trigeminal nucleus caudalis and calcitonin gene related peptide (CGRP) in the periaqueductal grey matter...
March 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29615706/analysis-of-the-camkii%C3%AE-and-%C3%AE-splice-variant-distribution-among-brain-regions-reveals-isoform-specific-differences-in-holoenzyme-formation
#13
Sarah G Cook, Ashley M Bourke, Heather O'Leary, Vincent Zaegel, Erika Lasda, Janna Mize-Berge, Nidia Quillinan, Chandra L Tucker, Steven J Coultrap, Paco S Herson, K Ulrich Bayer
Four CaMKII isoforms are encoded by distinct genes, and alternative splicing within the variable linker-region generates additional diversity. The α and β isoforms are largely brain-specific, where they mediate synaptic functions underlying learning, memory and cognition. Here, we determined the α and β splice-variant distribution among different mouse brain regions. Surprisingly, the nuclear variant αB was detected in all regions, and even dominated in hypothalamus and brain stem. For CaMKIIβ, the full-length variant dominated in most regions (with higher amounts of minor variants again seen in hypothalamus and brain stem)...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614493/propofol-disrupts-aerobic-glycolysis-in-colorectal-cancer-cells-via-inactivation-of-the-nmdar-camkii-erk-pathway
#14
Xiangyuan Chen, Qichao Wu, Pengfei Sun, Yanjun Zhao, Minmin Zhu, Changhong Miao
BACKGROUND/AIMS: To investigate the effect of propofol on glucose metabolism in colorectal cancer cells and in an in vivo xenograft model. METHODS: Glucose metabolism was assessed by measuring the extracellular acidification rate in HT29 and SW480 colorectal cancer cells. Quantitative real-time PCR and western blot analyses were used to detect mRNA and protein levels, respectively. Intracellular calcium was assessed by using a Fluo-3 AM fluorescence kit. Micro-positron emission tomography/computed tomography (microPET/CT) imaging was used to analyze glucose metabolism in the tumors of the xenograft model...
March 26, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29614314/glun2b-camkii-mediates-cfa-induced-hyperalgesia-via-hdac4-modified-spinal-cox2-transcription
#15
Cheng-Yuan Lai, Ming-Chun Hsieh, Yu-Cheng Ho, Gin-Den Chen, Dylan Chou, Ting Ruan, An-Sheng Lee, Hsueh-Hsiao Wang, Yat-Pang Chau, Hsien-Yu Peng, Cheng-Hung Lai
Histone deacetylase 4 (HDAC4), which actively shuttles between the nucleus and cytoplasm, is an attractive candidate for a repressor mechanism in epigenetic modification. However, the potential role of HDAC4-dependent epigenetics in the neural plasticity underlying the development of inflammatory pain has not been well established. By injecting complete Freund's adjuvant (CFA) into the hind-paw of Sprague-Dawley rats (200-250 g), we found animals displayed behavioral hyperalgesia was accompanied with HDAC4 phosphorylation and cytoplasmic redistribution in the dorsal horn neurons...
March 31, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29614261/the-novel-camkii-inhibitor-gs-680-reduces-diastolic-sr-ca-leak-and-prevents-camkii-dependent-pro-arrhythmic-activity
#16
S Lebek, A Plößl, M Baier, J Mustroph, D Tarnowski, C M Lücht, S Schopka, B Floerchinger, C Schmid, Y Zausig, N Pagratis, B Marchand, D O Koltun, W K Hung, S Ahmadyar, L Belardinelli, L S Maier, S Wagner
RATIONALE: Ca/calmodulin-dependent protein kinase II (CaMKII) was shown to increase diastolic sarcoplasmic reticulum (SR) Ca leak, which can result in delayed afterdepolarizations and triggered arrhythmias. Since increased CaMKII expression and activity has been mechanistically linked to arrhythmias in human heart failure (HF) and atrial fibrillation (AF), specific strategies aimed at CaMKII inhibition may have therapeutic potential. OBJECTIVE: We tested the antiarrhythmic and inotropic effects of a novel selective and ATP-competitive CaMKII inhibitor (GS-680)...
March 31, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29608040/muscle-restricted-nuclear-receptor-interaction-protein-knockout-causes-motor-neuron-degeneration-through-down-regulation-of-myogenin-at-the-neuromuscular-junction
#17
Hsin-Hsiung Chen, Li-Kai Tsai, Kuan-Yu Liao, Tung-Chien Wu, Yun-Hsin Huang, Yuan-Chun Huang, Szu-Wei Chang, Pei-Yu Wang, Yeou-Ping Tsao, Show-Li Chen
BACKGROUND: Nuclear receptor interaction protein (NRIP) is a calcium/calmodulin (CaM) binding protein. Nuclear receptor interaction protein interacts with CaM to activate calcineurin and CaMKII signalling. The conventional NRIP knockout mice (global knockout) showed muscular abnormality with reduction of muscle oxidative functions and motor function defects. METHODS: To investigate the role of NRIP on neuromuscular system, we generated muscle-restricted NRIP knockout mice [conditional knockout (cKO)]...
April 2, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29607715/hedgehog-signaling-contributes-to-bone-cancer-pain-by-regulating-sensory-neuron-excitability-in-rats
#18
Su Liu, You Lv, Xin-Xin Wan, Zhi-Jing Song, Yue-Peng Liu, Shuai Miao, Guang-Lei Wang, Gong-Jian Liu
Treating bone cancer pain continues to be a clinical challenge and underlying mechanisms of bone cancer pain remain elusive. Here, we reported that sonic hedgehog signaling plays a critical role in the development of bone cancer pain. Tibia bone cavity tumor cell implantation produces bone cancer-related mechanical allodynia, thermal hyperalgesia, and spontaneous and movement-evoked pain behaviors. Production and persistence of these pain behaviors are well correlated with tumor cell implantation-induced up-regulation and activation of sonic hedgehog signaling in primary sensory neurons and spinal cord...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29604078/maternal-undernutrition-in-late-gestation-increases-igf2-signalling-molecules-and-collagen-deposition-in-the-right-ventricle-of-the-fetal-sheep-heart
#19
Jack R T Darby, I Caroline McMillen, Janna L Morrison
Exposure of the fetus to a range of environmental stressors, including maternal undernutrition, is associated with an increased risk of death from cardiovascular disease (CVD) in adult life. This study aimed to determine the effect of maternal nutrient restriction in late gestation on the molecular mechanisms that regulate cardiac growth and development of the fetal heart. Maternal undernutrition resulted in a decrease in fetal glucose concentrations across late gestation, whilst fetal arterial PO2 remained unchanged between the control and late gestation undernutrition (LGUN) groups...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29603329/calcium-calmodulin-dependent-protein-kinaseii-in-occlusion-induced-degenerative-cartilage-of-rat-mandibular-condyle
#20
Qian Liu, Hong-Xu Yang, Xiang-Hong Wan, Mian Zhang, Jing Zhang, Lei Lu, Mianjiao Xie, Hao-Tian Ren, Shi-Bin Yu, Xiao-Dong Liu, Meiqing Wang
Activated calcium/calmodulin dependent protein kinaseII (CaMKII) is important to promote chondrocytes from proliferative to pre-hypertrophic state, which probably plays a role in osteoarthritis (OA), a wide-spread degeneration disease with enhanced aberrant chondrocyte differentiation. Our aim is to detect the role of CaMKII, and its relationship with Indian hedgehog (Ihh)-Parathyroid-related peptide (PTHrP) feedback loop in the temporomandibular joints (TMJs) OA. KN93, the competitive inhibitor of CaMKII, was added to the culture medium in vitro, and was locally injected to rats TMJs (n=54, female) every other day for 4 weeks from the beginning of the 5th and 9th week after installing of unilateral anterior crossbite (UAC), termed as 4wk+4wk and 8wk+4wk, accordingly...
March 30, 2018: Journal of Oral Rehabilitation
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