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JOURNAL ARTICLE
Benear Apollo Obanda, Cheryl L Gibbons, Eric M Fèvre, Lilly Bebora, George Gitao, William Ogara, Shu-Hua Wang, Wondwossen Gebreyes, Ronald Ngetich, Beth Blane, Francesc Coll, Ewan M Harrison, Samuel Kariuki, Sharon J Peacock, Elizabeth A J Cook
Abattoir workers have been identified as high-risk for livestock-associated Staphylococcus aureus carriage. This study investigated S. aureus carriage in abattoir workers in Western Kenya. Nasal swabs were collected once from participants between February-November 2012. S. aureus was isolated using bacterial culture and antibiotic susceptibility testing performed using the VITEK 2 instrument and disc diffusion methods. Isolates underwent whole genome sequencing and Multi Locus Sequence Types were derived from these data...
December 1, 2022: Antibiotics
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JOURNAL ARTICLE
Katherine I Swenson-Fields, Christopher J Ward, Micaila E Lopez, Shaneann Fross, Anna L Heimes Dillon, James D Meisenheimer, Adib J Rabbani, Emily Wedlock, Malay K Basu, Kyle P Jansson, Peter S Rowe, Jason R Stubbs, Darren P Wallace, Michael P Vitek, Timothy A Fields
We and others have previously shown that the presence of renal innate immune cells can promote polycystic kidney disease (PKD) progression. In this study, we examined the influence of the inflammasome, a key part of the innate immune system, on PKD. The inflammasome is a system of molecular sensors, receptors, and scaffolds that responds to stimuli like cellular damage or microbes by activating Caspase-1, and generating critical mediators of the inflammatory milieu, including IL-1β and IL-18. We provide evidence that the inflammasome is primed in PKD, as multiple inflammasome sensors were upregulated in cystic kidneys from human ADPKD patients, as well as in kidneys from both orthologous ( PKD1 RC/RC or RC/RC) and non-orthologous ( jck ) mouse models of PKD...
2022: Frontiers in Molecular Biosciences
#23
JOURNAL ARTICLE
Ajay K Verma, Ying Yu, Sergio F Acosta-Lenis, Tyler Havel, David Escobar Sanabria, Gregory F Molnar, Colum D MacKinnon, Michael J Howell, Jerrold L Vitek, Luke A Johnson
Excessive daytime sleepiness is a recognized non-motor symptom that adversely impacts the quality of life of people with Parkinson's disease (PD), yet effective treatment options remain limited. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for PD motor signs. Reliable daytime sleep-wake classification using local field potentials (LFPs) recorded from DBS leads implanted in STN can inform the development of closed-loop DBS approaches for prompt detection and disruption of sleep-related neural oscillations...
December 12, 2022: Neurobiology of Disease
#24
JOURNAL ARTICLE
D L Church, T Griener, D Gregson
BACKGROUND: Our large regional laboratory routinely provides a definitive identification (ID) for 800-1,200 anaerobic bacteria per annum that cause invasive human infections. An increasing number of isolates (i.e., 10-13%) recovered from clinical specimens from these cases were more unusual or rarely isolated genera and/or species (i.e., ≤5 individual cases/annum). METHODS: VITEK® MS (MALDI-TOF MS)is done initially on all anaerobic bacteria, but rare isolates undergo in-house PCR/sequencing when proteomics provides a wrong ID or no results despite repeat testing...
September 17, 2022: Anaerobe
#25
JOURNAL ARTICLE
Ajay K Verma, Sergio Francisco Acosta Lenis, Joshua E Aman, David Escobar Sanabria, Jing Wang, Amy Pearson, Meghan Hill, Remi Patriat, Lauren E Schrock, Scott E Cooper, Michael C Park, Noam Harel, Michael J Howell, Colum D MacKinnon, Jerrold L Vitek, Luke A Johnson
To elucidate the role of the basal ganglia during REM sleep movements in Parkinson's disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements...
September 12, 2022: NPJ Parkinson's Disease
#26
JOURNAL ARTICLE
X J Zhou, C R Chen, X M Wang, H Wu, T Huang, L N Wang, Lina Niu
There is a rare case of an elderly diabetic with diabetic foot infection at Hainan General Hospital in September 2021, which was diagnosed as Corynebacterium diphtheriae infection incidentally on routine culture with conventional methods and molecular biological approaches, to aid in diagnosis in clinical practice. Owing to smear staining, Albert staining and VITEK 2 system, automated identification systems viz matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) confirmed combing with 16S ribosomal RNA (16S rRNA) gene has been used for the taxonomic classification of bacteria...
August 6, 2022: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
#27
JOURNAL ARTICLE
David Escobar Sanabria, Joshua E Aman, Valentina Zapata Amaya, Luke A Johnson, Hafsa Farooqi, Jing Wang, Meghan Hill, Remi Patriat, Kelly Sovell-Brown, Gregory F Molnar, David Darrow, Robert McGovern, Scott E Cooper, Noam Harel, Colum D MacKinnon, Michael C Park, Jerrold L Vitek
Approaches to control basal ganglia neural activity in real-time are needed to clarify the causal role of 8-35 Hz ("beta band") oscillatory dynamics in the manifestation of Parkinson's disease (PD) motor signs. Here, we show that resonant beta oscillations evoked by electrical pulse with precise amplitude and timing can be used to predictably suppress or amplify spontaneous beta band activity in the internal segment of the globus pallidus (GPi) in the human. Using this approach, referred to as closed-loop evoked interference deep brain stimulation (eiDBS), we could suppress or amplify frequency-specific (16-22 Hz) neural activity in a PD patient...
July 31, 2022: Brain Stimulation
#28
JOURNAL ARTICLE
T D Verschuuren, T Bosch, V Mascaro, R J L Willems, J A J W Kluytmans
OBJECTIVE: To externally validate whole genome sequence-antimicrobial susceptibility testing (WGS-AST) phenotype prediction tools KOVER-AMR and ResFinder 4.1 for Escherichia coli clinical isolates from Dutch routine care. METHODS: A random sample of 234 E. coli, and 283 3rd generation cephalosporin-resistant E. coli isolates from urine and blood were collected (2014-17). Culture-AST was performed using VITEK 2 and BD Phoenix. Sequences were used as input for KOVER-AMR-SCM, KOVER-AMR-CART and ResFinder 4...
June 1, 2022: Clinical Microbiology and Infection
#29
JOURNAL ARTICLE
John-Paul Mutebi, André Barretto Bruno Wilke, Erik Ostrum, Chalmers Vasquez, Gabriel Cardenas, Augusto Carvajal, Maday Moreno, William D Petrie, Arturo Rodriguez, Henry Presas, Jesus Rodriguez, Fred Barnes, Gabriel L Hamer, Jose G Juarez, Ester Carbajal, Christopher J Vitek, Xochitl Estrada, Thalia Rios, Jeremy Marshall, John C Beier
The diel biting activity of Aedes (Stegomyia) aegypti (L) populations was extensively investigated in the early 1900s to gain more information on the biology of Ae. aegypti, and this information was used to devise effective approaches to controlling populations of this species and protect the human population from widespread arbovirus outbreaks. However, few contemporary studies are available regarding the diel activity patterns of Ae. aegypti. To assess the diel activity patterns of Ae. aegypti in southern Florida and Texas, we conducted 96-h uninterrupted mosquito collections once each month from May through November 2019 in Miami, Florida, and Brownsville, Texas, using BG-Sentinel 2 Traps...
March 29, 2022: Scientific Reports
#30
JOURNAL ARTICLE
Liewei Wang, Steven E Scherer, Suzette J Bielinski, Donna M Muzny, Leila A Jones, John Logan Black, Ann M Moyer, Jyothsna Giri, Richard R Sharp, Eric T Matey, Jessica A Wright, Lance J Oyen, Wayne T Nicholson, Mathieu Wiepert, Terri Sullard, Timothy B Curry, Carolyn R Rohrer Vitek, Tammy M McAllister, Jennifer L St Sauver, Pedro J Caraballo, Konstantinos N Lazaridis, Eric Venner, Xiang Qin, Jianhong Hu, Christie L Kovar, Viktoriya Korchina, Kimberly Walker, HarshaVardhan Doddapaneni, Tsung-Jung Wu, Ritika Raj, Shawn Denson, Wen Liu, Gauthami Chandanavelli, Lan Zhang, Qiaoyan Wang, Divya Kalra, Mary Beth Karow, Kimberley J Harris, Hugues Sicotte, Sandra E Peterson, Amy E Barthel, Brenda E Moore, Jennifer M Skierka, Michelle L Kluge, Katrina E Kotzer, Karen Kloke, Jessica M Vander Pol, Heather Marker, Joseph A Sutton, Adrijana Kekic, Ashley Ebenhoh, Dennis M Bierle, Michael J Schuh, Christopher Grilli, Sara Erickson, Audrey Umbreit, Leah Ward, Sheena Crosby, Eric A Nelson, Sharon Levey, Michelle Elliott, Steve G Peters, Naveen Pereira, Mark Frye, Fadi Shamoun, Matthew P Goetz, Iftikhar J Kullo, Robert Wermers, Jan A Anderson, Christine M Formea, Razan M El Melik, John D Zeuli, Joseph R Herges, Carrie A Krieger, Robert W Hoel, Jodi L Taraba, Scott R St Thomas, Imad Absah, Matthew E Bernard, Stephanie R Fink, Andrea Gossard, Pamela L Grubbs, Therese M Jacobson, Paul Takahashi, Sharon C Zehe, Susan Buckles, Michelle Bumgardner, Colette Gallagher, Kelliann Fee-Schroeder, Nichole R Nicholas, Melody L Powers, Ahmed K Ragab, Darcy M Richardson, Anthony Stai, Jaymi Wilson, Joel E Pacyna, Janet E Olson, Erica J Sutton, Annika T Beck, Caroline Horrow, Krishna R Kalari, Nicholas B Larson, Hongfang Liu, Liwei Wang, Guilherme S Lopes, Bijan J Borah, Robert R Freimuth, Ye Zhu, Debra J Jacobson, Matthew A Hathcock, Sebastian M Armasu, Michaela E McGree, Ruoxiang Jiang, Tyler H Koep, Jason L Ross, Matthew G Hilden, Kathleen Bosse, Bronwyn Ramey, Isabelle Searcy, Eric Boerwinkle, Richard A Gibbs, Richard M Weinshilboum
PURPOSE: The Mayo-Baylor RIGHT 10K Study enabled preemptive, sequence-based pharmacogenomics (PGx)-driven drug prescribing practices in routine clinical care within a large cohort. We also generated the tools and resources necessary for clinical PGx implementation and identified challenges that need to be overcome. Furthermore, we measured the frequency of both common genetic variation for which clinical guidelines already exist and rare variation that could be detected by DNA sequencing, rather than genotyping...
May 2022: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#31
JOURNAL ARTICLE
Dusten T Rose, Alexander Moskhos, Arya Wibisono, Kelly R Reveles
OBJECTIVES: Variability in minimum inhibitory concentration (MIC) with automated susceptibility testing instruments may influence methicillin-resistant Staphylococcus aureus (MRSA) treatment. The purpose of this study was to evaluate the difference in vancomycin MIC values and the impact on vancomycin alternative therapy for MRSA bacteremia using the MicroScan and Vitek 2 automated systems. METHODS: This was a retrospective multicenter cohort study of adult patients with MRSA bacteremia...
February 5, 2022: International Journal of Infectious Diseases: IJID
#32
JOURNAL ARTICLE
Chiahao Lu, Kenneth H Louie, Emily L Twedell, Jerrold L Vitek, Colum D MacKinnon, Scott E Cooper
BACKGROUND: Treadmills provide a safe and convenient way to study the gait of people with Parkinson's disease (PD), but outcome measures derived from treadmill gait may differ from overground walking. OBJECTIVE: To investigate how the relationships between gait metrics and walking speed vary between overground and treadmill walking in people with PD and healthy controls. METHODS: We compared 29 healthy controls to 27 people with PD in the OFF-medication state...
January 26, 2022: Gait & Posture
#33
REVIEW
Laurien De Roeck, Hiska L van der Weide, Daniëlle B P Eekers, Miranda C Kramer, Claire Alapetite, Malin Blomstrand, Neil G Burnet, Valentin Calugaru, Ida E M Coremans, Dario Di Perri, Semi Harrabi, Alberto Iannalfi, Yvonne L B Klaver, Johannes A Langendijk, Alejandra Méndez Romero, Frank Paulsen, Erik Roelofs, Dirk de Ruysscher, Beate Timmermann, Pavel Vitek, Damien C Weber, Gillian A Whitfield, Petra Witt Nyström, Jaap Zindler, Esther G C Troost, Maarten Lambrecht
PURPOSE: Treatment-related toxicity after irradiation of brain tumours has been underreported in the literature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim of this European Particle Network (EPTN) collaborative project is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy. METHODS: A Delphi method-based consensus was reached among 24 international radiation-oncology experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time points...
March 2022: Radiotherapy and Oncology
#34
JOURNAL ARTICLE
B Su, L Cao, J Zheng, L Zhang, Z Zhang, F Qiu
OBJECTIVE: To characterize the bacterial strain LGV03 isolated from the reproductive tract of healthy women and evaluate its safety. METHODS: The bacterial strains were isolated and purified using MRS agar by dilution plating and streak plate method. Gram staining was used to observe the morphology of the isolated strains and identify Gram-negative and -positive strains. The physiological and biochemical properties of the bacteria was assessed using VITEK ANC card...
December 20, 2021: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
#35
JOURNAL ARTICLE
Hiroshi Morioka, Keisuke Oka, Yosuke Yamada, Yoshimasa Nakane, Hitoshi Komiya, Chiaki Murase, Mitsutaka Iguchi, Tetsuya Yagi
A 93-year-old woman was diagnosed with Lysinibacillus fusiformis bacteremia complicated with coma blisters. Initial gram staining for L. fusiformis indicated the presence of gram-negative rods; however, subsequent staining of colonies from Mueller-Hinton agar revealed the presence of gram-positive and gram-negative rods with spherical endospores, and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (VITEK ® MS and microflex® LT/SH) definitively identified the organism as L. fusiformis...
December 2, 2021: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#36
JOURNAL ARTICLE
Lindsey E Nielsen, Ken Nguyen, Clinton K Wahl, Jodi L Huss, David Chang, Edward P Ager, Lynette Hamilton
BACKGROUND: In suspected bloodstream infections, accurate blood culture results are critical to timely diagnoses and appropriate antibiotic administration. AIM: An Initial Specimen Diversion Device®, Steripath®, (Magnolia Medical Technologies, Seattle, WA) was evaluated for efficacy in reducing blood culture contamination at Brooke Army Medical Center (6.8% six-month contamination rate prior to intervention) in a six-month quality improvement project. METHODS: Blood cultures in the emergency department were collected using either Steripath® or the standard method...
November 12, 2021: Journal of Hospital Infection
#37
JOURNAL ARTICLE
C Hickey, S Nguyen, J Anes, D Hurley, O O'Donoghue, S Fanning, K Schaffer
OBJECTIVES: IMP-type carbapenemases are rarely detected in Europe and limited information is available to guide the treatment of infections caused by carbapenemase-producing Enterobacterales (CPE) producing these carbapenemases. Accurate antimicrobial susceptibility testing (AST) results are essential for optimal antibiotic management. Here we report discrepancies in AST of IMP-producing Enterobacterales (IMP-CPE) complicating the management of severe sepsis. METHODS: Antimicrobial susceptibilities were analysed by in-house VITEK® 2, Etest and broth microdilution (BMD)...
November 11, 2021: Journal of Global Antimicrobial Resistance
#38
JOURNAL ARTICLE
Eric T Matey, Ashley Kate Ragan, Lance J Oyen, Carolyn R Vitek, Stacy L Aoudia, Ahmed K Ragab, Kelliann C Fee-Schroeder, John L Black, Ann M Moyer, Wayne T Nicholson, Sofia Shrestha, Tammy M McAllister, Jason P Sinnwell, Stephanie S Faubion, Konstantinos N Lazaridis
PURPOSE: The Pharmacogenomics (PGx) Profile Service was a proof-of-concept project to implement PGx in patient care at Mayo Clinic. METHODS: Eighty-two healthy individuals aged 18 and older underwent genotyping of CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, SLCO1B1, HLA-B*58:01, and VKORC1. A PGx pharmacist was involved in ordering, meeting with patients, interpreting, reviewing, and documenting results. RESULTS: Ninety three percent were CYP1A2 rapid metabolizers, 92% CYP3A4 normal metabolizers, and 88% CYP3A5 poor metabolizers; phenotype frequencies for CYP2C19 and CYP2D6 varied...
February 2022: Pharmacogenomics Journal
#39
JOURNAL ARTICLE
M H Huang, H Wu, L L Liu, X M Wang
Burkholderia pseudomallei (B. pseudomallei) is the etiologic agent of melioidosis. The aim of this study was to establish a SuperSpectrum of B. pseudomallei in Hainan and evaluate its application value in the rapid identification of clinical isolates of B. pseudomallei . In total, 99 isolates of B. pseudomallei were obtained between 2010-2019 in different regions of Hainan Province, multilocus sequence typing (MLST) was performed, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was applied for spectrum acquisition...
September 2021: New Microbes and New Infections
#40
JOURNAL ARTICLE
Sheriza Baksh, Anne Casper, Mindy S Christianson, Kate Devine, Kevin J Doody, Stephan Ehrhardt, Karl R Hansen, Ruth B Lathi, Fatmata Timbo, Rebecca Usadi, Wendy Vitek, David M Shade, James Segars, Valerie L Baker
BACKGROUND: Randomized trials of assisted reproductive technology (ART) have been designed for outcomes of clinical pregnancy or live birth and have not been powered for obstetric outcomes such as preeclampsia, critical for maternal and fetal health. ART increasingly involves frozen embryo transfer (FET). Although there are advantages of FET, multiple studies have shown that risk of preeclampsia is increased with FET compared with fresh embryo transfer, and the reason for this difference is not clear...
September 27, 2021: Trials
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