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Vitek, j.l.

J N Vieira, A M Feijó, M E Bueno, C L Gonçalves, R G Lund, J F Mendes, J P V Villarreal, M M Villela, P S Nascente
The aim of this study was to evaluate the frequency of Candida species between a non-hospitalized and a hospitalized population. For this purpose, samples of saliva were sampled through sterile swabs, moistened in peptone water and rubbed in the oral cavity of 140 individuals, from which, 70 were hospitalized patients from the Medical Clinic of a Teaching Hospital and the other 70 were non-hospitalized subjects. All saliva samples were plated in Sabouraud Dextrose agar added with Chloramphenicol and incubated at 36 °C for 48 hours...
February 15, 2018: Brazilian Journal of Biology, Revista Brasleira de Biologia
C H Freitas, J F Mendes, P V Villarreal, P R Santos, C L Gonçalves, H L Gonzales, P S Nascente
Mastitis is an inflammatory process of the udder tissue caused mainly by the bacteria Staphylococcus aureus. The indiscriminate use of antibiotics fosters conditions that favor the selection of resistant microorganisms, suppressing at the same time susceptible forms, causing a serious problem in dairy cattle. Given the importance in performing an antibiogram to select the most adequate antimicrobial therapy, the aim of this study was to identify bacteria isolated from cow's milk with mastitis, in dairy farms situated in the city of Pelotas, Rio Grande do Sul, and to determinate the susceptibility profile of these isolates against the antibiotics used to treat this illness...
January 8, 2018: Brazilian Journal of Biology, Revista Brasleira de Biologia
S J Zhao, Y Q Fu, M X Zhu, H Zhou, M Xu, R L Yan, Y X Shui, J Y Zhou
Objective: To analyze the drug resistance of Escherichia coli (E.coli) from bloodstream infection (BSI) and the predictors of mortality in E. coli bloodstream infection (BSI). Methods: The clinical data of 139 E. coli BSI cases diagnosed from January 2012 to December 2015 in The Second Affiliated Hospital of Zhejiang University School of Medicine, Lanxi Branch (Lanxi People's Hospital), Zhejiang Province, were retrospectively analyzed. The antimicrobial susceptibility testing was performed using Vitek 2 system...
August 22, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Sasha R Azar, Christopher M Roundy, Shannan L Rossi, Jing H Huang, Grace Leal, Ruimei Yun, Ildefonso Fernandez-Salas, Christopher J Vitek, Igor A D Paploski, Pamela M Stark, Jeremy Vela, Mustapha Debboun, Martin Reyna, Uriel Kitron, Guilherme S Ribeiro, Kathryn A Hanley, Nikos Vasilakis, Scott C Weaver
To evaluate the potential role of Aedes albopictu s (Skuse) as a vector of Zika virus (ZIKV), colonized mosquitoes of low generation number (≤ F5) from Brazil, Houston, and the Rio Grande Valley of Texas engorged on viremic mice infected with ZIKV strains originating from Senegal, Cambodia, Mexico, Brazil, or Puerto Rico. Vector competence was established by monitoring infection, dissemination, and transmission potential after 3, 7, and 14 days of extrinsic incubation. Positive saliva samples were assayed for infectious titer...
August 2017: American Journal of Tropical Medicine and Hygiene
C C Papagiannitsis, E Malli, Z Florou, M Medvecky, S Sarrou, J Hrabak, E Petinaki
OBJECTIVES: An Enterococcus faecium isolate (Efa-125) carrying both the vanA and vanB genes was recovered from a patient with bacteraemia treated in a Greek hospital. Since this is the first description in Europe of E. faecium carrying both vanA and vanB genes, the isolate was further studied. METHODS: Susceptibility to several antibiotics was determined using the VITEK® 2 automated system. The isolate was typed by multilocus sequence typing (MLST). To define the genetic units of the vanA and vanB genes, the plasmid content of Efa-125 was analysed by pulsed-field gel electrophoresis (PFGE) of total DNA digested with S1 nuclease followed by hybridisation with digoxigenin-labelled vanA and vanB probes...
December 2017: Journal of Global Antimicrobial Resistance
J F Mendes, C L Gonçalves, G F Ferreira, I A Esteves, C H Freitas, J P V Villarreal, J R B Mello, M C A Meireles, P S Nascente
Yeast infections have acquired great importance due to increasing frequency in immunocompromised patients or patients undergoing invasive diagnostic and therapeutic techniques, and also because of its high morbidity and mortality. At the same time, it has been seen an increase in the emergence of new pathogenic species difficult to diagnose and treat. The aim of this study was to determine the in vitro susceptibility of 89 yeasts from different sources against the antifungals amphotericin B, voriconazole, fluconazole and flucytosine, using the VITEK® 2 Compact system...
July 10, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
M Robin, R Porcher, W Zinke-Cerwenka, A van Biezen, L Volin, G Mufti, C Craddock, J Finke, C Richard, J Passweg, A Peniket, J Maertens, G Sucak, T Gedde-Dahl, A Vitek, A Nagler, D Blaise, D Beelen, N Maillard, R Schwerdtfeger, T de Witte, N Kroger
This corrects the article DOI: 10.1038/bmt.2016.266.
July 2017: Bone Marrow Transplantation
Madhan R Tirumalai, Fathi Karouia, Quyen Tran, Victor G Stepanov, Rebekah J Bruce, C Mark Ott, Duane L Pierson, George E Fox
Microorganisms impact spaceflight in a variety of ways. They play a positive role in biological systems, such as waste water treatment but can be problematic through buildups of biofilms that can affect advanced life support. Of special concern is the possibility that during extended missions, the microgravity environment will provide positive selection for undesirable genomic changes. Such changes could affect microbial antibiotic sensitivity and possibly pathogenicity. To evaluate this possibility, Escherichia coli (lac plus) cells were grown for over 1000 generations on Luria Broth medium under low-shear modeled microgravity conditions in a high aspect rotating vessel...
2017: NPJ Microgravity
Carolyn R Rohrer Vitek, Noura S Abul-Husn, John J Connolly, Andrea L Hartzler, Terrie Kitchner, Josh F Peterson, Luke V Rasmussen, Maureen E Smith, Sarah Stallings, Marc S Williams, Wendy A Wolf, Cynthia A Prows
Ten organizations within the Electronic Medical Records and Genomics Network developed programs to implement pharmacogenomic sequencing and clinical decision support into clinical settings. Recognizing the importance of informed prescribers, a variety of strategies were used to incorporate provider education to support implementation. Education experiences with pharmacogenomics are described within the context of each organization's prior involvement, including the scope and scale of implementation specific to their Electronic Medical Records and Genomics projects...
June 22, 2017: Pharmacogenomics
R Martino, A Henseler, M van Lint, N Schaap, J Finke, D Beelen, S Vigouroux, E P Alessandrino, G J Mufti, J H Veelken, B Bruno, I Yakoub-Agha, L Volin, J Maertens, R Or, V Leblond, M Rovira, P Kalhs, A F Alvarez, A Vitek, J Sierra, E Wagner, M Robin, T de Witte, N Kröger
This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0...
August 2017: Bone Marrow Transplantation
Christopher M Roundy, Sasha R Azar, Shannan L Rossi, Jing H Huang, Grace Leal, Ruimei Yun, Ildefonso Fernandez-Salas, Christopher J Vitek, Igor A D Paploski, Uriel Kitron, Guilherme S Ribeiro, Kathryn A Hanley, Scott C Weaver, Nikos Vasilakis
To test whether Zika virus has adapted for more efficient transmission by Aedes aegypti mosquitoes, leading to recent urban outbreaks, we fed mosquitoes from Brazil, the Dominican Republic, and the United States artificial blood meals containing 1 of 3 Zika virus strains (Senegal, Cambodia, Mexico) and monitored infection, dissemination, and virus in saliva. Contrary to our hypothesis, Cambodia and Mexica strains were less infectious than the Senegal strain. Only mosquitoes from the Dominican Republic transmitted the Cambodia and Mexica strains...
April 2017: Emerging Infectious Diseases
Susan Abbatiello, Bradley L Ackermann, Christoph Borchers, Ralph A Bradshaw, Steven A Carr, Robert Chalkley, Meena Choi, Eric Deutsch, Bruno Domon, Andrew N Hoofnagle, Hasmik Keshishian, Eric Kuhn, Daniel C Liebler, Michael MacCoss, Brendan MacLean, D R Mani, Hendrik Neubert, Derek Smith, Olga Vitek, Lisa Zimmerman
No abstract text is available yet for this article.
March 2017: Molecular & Cellular Proteomics: MCP
Ibdanelo Cortez, Christopher J Vitek, Michael W Persans, Kristine L Lowe
Atrazine is a widely-used herbicide that can impact non-target organisms in the environment but can be biologically degraded by several types of microorganisms. In this study, the gene atzA, which encodes for the initial step in bacterially-mediated atrazine degradation, was used as an indicator of atrazine pollution in agricultural canals located in Hidalgo County, Texas, USA. The concentration of atrazine and atzA were monitored once per month for 12 months during 2010-2011. Atrazine was measured using an enzyme-linked immunosorbent assay; atzA abundance was monitored using Quantitative Polymerase Chain Reaction (Q-PCR) analyses...
February 2017: World Journal of Microbiology & Biotechnology
J Schetelig, L C de Wreede, M van Gelder, N S Andersen, C Moreno, A Vitek, M Karas, M Michallet, M Machaczka, M Gramatzki, D Beelen, J Finke, J Delgado, L Volin, J Passweg, P Dreger, A Henseler, A van Biezen, M Bornhäuser, S O Schönland, N Kröger
For young patients with high-risk CLL, BTK-/PI3K-inhibitors or allogeneic stem cell transplantation (alloHCT) are considered. Patients with a low risk of non-relapse mortality (NRM) but a high risk of failure of targeted therapy may benefit most from alloHCT. We performed Cox regression analyses to identify risk factors for 2-year NRM and 5-year event-free survival (using EFS as a surrogate for long-term disease control) in a large, updated EBMT registry cohort (n= 694). For the whole cohort, 2-year NRM was 28% and 5-year EFS 37%...
April 2017: Bone Marrow Transplantation
Janet E Olson, Carolyn R Rohrer Vitek, Elizabeth J Bell, Michaela E McGree, Debra J Jacobson, Jennifer L St Sauver, Pedro J Caraballo, Joan M Griffin, Veronique L Roger, Suzette J Bielinski
PURPOSE: To examine predictors of understanding preemptive CYP2D6 pharmacogenomics test results and to identify key features required to improve future educational efforts of preemptive pharmacogenomics testing. METHODS: One thousand ten participants were surveyed after receiving preemptive CYP2D6 pharmacogenomics test results. RESULTS: Eighty-six percent (n = 869) of patients responded. Of the responders, 98% were white and 55% were female; 57% had 4 years or more of post-secondary education and an average age of 58...
July 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Nina J Hos, Nathalie Jazmati, Danuta Stefanik, Martin Hellmich, Halil AlSael, Winfried V Kern, Siegbert Rieg, Hilmar Wisplinghoff, Harald Seifert, Achim J Kaasch
OBJECTIVES: Elevated vancomycin minimum inhibitory concentrations (MIC) have been reported to adversely affect clinical outcome in methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI). We therefore examined the association between vancomycin MIC and outcome considering various potential confounders. METHODS: Clinical data and bacterial isolates were prospectively collected from patients with MRSA BSI from 2006 to 2012 as part of the Invasive Staphylococcus aureus Infection Cohort (INSTINCT) study...
March 2017: Journal of Infection
A Dvořák, J Zelenka, K Smolková, L Vítek, P JeŽek
Each cell types or tissues contain certain "physiological" levels of R-2-hydroxyglutarate (2HG), as well as enzymes for its synthesis and degradation. 2HG accumulates in certain tumors, possessing heterozygous point mutations of isocitrate dehydrogenases IDH1 (cytosolic) or IDH2 (mitochondrial) and contributes to strengthening their malignancy by inhibiting 2-oxoglutarate-dependent dioxygenases. By blocking histone de-methylation and 5-methyl-cytosine hydroxylation, 2HG maintains cancer cells de-differentiated and promotes their proliferation...
May 4, 2017: Physiological Research
M van Gelder, L C de Wreede, M Bornhäuser, D Niederwieser, M Karas, N S Anderson, M Gramatzki, P Dreger, M Michallet, E Petersen, D Bunjes, M Potter, D Beelen, J J Cornelissen, I Yakoub-Agha, N H Russell, J Finke, H Schoemans, A Vitek, Á Urbano-Ispízua, D Blaise, L Volin, P Chevallier, D Caballero, H Putter, A van Biezen, A Henseler, S Schönland, N Kröger, J Schetelig
Even with the availability of targeted drugs, allogeneic hematopoietic cell transplantation (allo-HCT) is the only therapy with curative potential for patients with CLL. Cure can be assessed by comparing long-term survival of patients to the matched general population. Using data from 2589 patients who received allo-HCT between 2000 and 2010, we used landmark analyses and methods from relative survival analysis to calculate excess mortality compared with an age-, sex- and calendar year-matched general population...
December 12, 2016: Bone Marrow Transplantation
M Robin, R Porcher, W Zinke-Cerwenka, A van Biezen, L Volin, G Mufti, C Craddock, J Finke, C Richard, J Passweg, A Peniket, J Maertens, G Sucak, T Gedde-Dahl, A Vitek, A Nagler, D Blaise, D Beelen, N Maillard, R Schwerdtfeger, T de Witte, N Kroger
We report a retrospective analysis of 246 myelodysplastic syndrome (MDS) patients in the EBMT (The European Society for Blood and Marrow Transplantation) database who were transplanted for International Prognostic Scoring System (IPSS) low or intermediate-1 disease. The majority of these patients (76%) were reclassified as intermediate or higher risk according to R-IPSS. The 3-year overall survival (OS) and PFS were 58% and 54%, respectively. In a multivariate analysis, adverse risk factors for PFS were marrow blast percentage (hazard ratio (HR): 1...
February 2017: Bone Marrow Transplantation
S J Bielinski, J L St Sauver, J E Olson, M L Wieland, C R Vitek, E J Bell, M E Mc Gree, D J Jacobson, J B McCormick, P Y Takahashi, J L Black, P J Caraballo, R R Sharp, T J Beebe, R M Weinshilboum, L Wang, V L Roger
No abstract text is available yet for this article.
January 2017: Pharmacogenomics Journal
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