keyword
MENU ▼
Read by QxMD icon Read
search

Vitek, j.l.

keyword
https://www.readbyqxmd.com/read/28319072/long-term-follow-up-of-a-retrospective-comparison-of-reduced-intensity-conditioning-and-conventional-high-dose-conditioning-for-allogeneic-transplantation-from-matched-related-donors-in-myelodysplastic-syndromes
#1
R Martino, A Henseler, M van Lint, N Schaap, J Finke, D Beelen, S Vigouroux, E P Alessandrino, G J Mufti, J H Veelken, B Bruno, I Yakoub-Agha, L Volin, J Maertens, R Or, V Leblond, M Rovira, P Kalhs, A F Alvarez, A Vitek, J Sierra, E Wagner, M Robin, T de Witte, N Kröger
This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0...
March 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28287375/variation-in-aedes-aegypti-mosquito-competence-for-zika-virus-transmission
#2
Christopher M Roundy, Sasha R Azar, Shannan L Rossi, Jing H Huang, Grace Leal, Ruimei Yun, Ildefonso Fernandez-Salas, Christopher J Vitek, Igor A D Paploski, Uriel Kitron, Guilherme S Ribeiro, Kathryn A Hanley, Scott C Weaver, Nikos Vasilakis
To test whether Zika virus has adapted for more efficient transmission by Aedes aegypti mosquitoes, leading to recent urban outbreaks, we fed mosquitoes from Brazil, the Dominican Republic, and the United States artificial blood meals containing 1 of 3 Zika virus strains (Senegal, Cambodia, Mexico) and monitored infection, dissemination, and virus in saliva. Contrary to our hypothesis, Cambodia and Mexica strains were less infectious than the Senegal strain. Only mosquitoes from the Dominican Republic transmitted the Cambodia and Mexica strains...
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28183812/new-guidelines-for-publication-of-manuscripts-describing-development-and-application-of-targeted-mass-spectrometry-measurements-of-peptides-and-proteins
#3
EDITORIAL
Susan Abbatiello, Bradley L Ackermann, Christoph Borchers, Ralph A Bradshaw, Steven A Carr, Robert Chalkley, Meena Choi, Eric Deutsch, Bruno Domon, Andrew N Hoofnagle, Hasmik Keshishian, Eric Kuhn, Daniel C Liebler, Michael MacCoss, Brendan MacLean, D R Mani, Hendrik Neubert, Derek Smith, Olga Vitek, Lisa Zimmerman
No abstract text is available yet for this article.
March 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28120308/seasonal-detection-of-atrazine-and-atza-in-man-made-waterways-receiving-agricultural-runoff-in-a-subtropical-semi-arid-environment-hidalgo-county-texas-usa
#4
Ibdanelo Cortez, Christopher J Vitek, Michael W Persans, Kristine L Lowe
Atrazine is a widely-used herbicide that can impact non-target organisms in the environment but can be biologically degraded by several types of microorganisms. In this study, the gene atzA, which encodes for the initial step in bacterially-mediated atrazine degradation, was used as an indicator of atrazine pollution in agricultural canals located in Hidalgo County, Texas, USA. The concentration of atrazine and atzA were monitored once per month for 12 months during 2010-2011. Atrazine was measured using an enzyme-linked immunosorbent assay; atzA abundance was monitored using Quantitative Polymerase Chain Reaction (Q-PCR) analyses...
February 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28112746/risk-factors-for-treatment-failure-after-allogeneic-transplantation-of-patients-with-cll-a-report-from-the-european-society-for-blood-and-marrow-transplantation
#5
J Schetelig, L C de Wreede, M van Gelder, N S Andersen, C Moreno, A Vitek, M Karas, M Michallet, M Machaczka, M Gramatzki, D Beelen, J Finke, J Delgado, L Volin, J Passweg, P Dreger, A Henseler, A van Biezen, M Bornhäuser, S O Schönland, N Kröger
For young patients with high-risk CLL, BTK-/PI3K-inhibitors or allogeneic stem cell transplantation (alloHCT) are considered. Patients with a low risk of non-relapse mortality (NRM) but a high risk of failure of targeted therapy may benefit most from alloHCT. We performed Cox regression analyses to identify risk factors for 2-year NRM and 5-year event-free survival (using EFS as a surrogate for long-term disease control) in a large, updated EBMT registry cohort (n= 694). For the whole cohort, 2-year NRM was 28% and 5-year EFS 37%...
April 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28055020/participant-perceived-understanding-and-perspectives-on-pharmacogenomics-the-mayo-clinic-right-protocol-right-drug-right-dose-right-time
#6
Janet E Olson, Carolyn R Rohrer Vitek, Elizabeth J Bell, Michaela E McGree, Debra J Jacobson, Jennifer L St Sauver, Pedro J Caraballo, Joan M Griffin, Veronique L Roger, Suzette J Bielinski
PURPOSE: To examine predictors of understanding preemptive CYP2D6 pharmacogenomics test results and to identify key features required to improve future educational efforts of preemptive pharmacogenomics testing. METHODS: One thousand ten participants were surveyed after receiving preemptive CYP2D6 pharmacogenomics test results. RESULTS: Eighty-six percent (n = 869) of patients responded. Of the responders, 98% were white and 55% were female; 57% had 4 years or more of post-secondary education and an average age of 58...
January 5, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28017826/determining-vancomycin-etest-mics-in-patients-with-mrsa-bloodstream-infection-does-not-support-switching-antimicrobials
#7
Nina J Hos, Nathalie Jazmati, Danuta Stefanik, Martin Hellmich, Halil AlSael, Winfried V Kern, Siegbert Rieg, Hilmar Wisplinghoff, Harald Seifert, Achim J Kaasch
OBJECTIVES: Elevated vancomycin minimum inhibitory concentrations (MIC) have been reported to adversely affect clinical outcome in methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI). We therefore examined the association between vancomycin MIC and outcome considering various potential confounders. METHODS: Clinical data and bacterial isolates were prospectively collected from patients with MRSA BSI from 2006 to 2012 as part of the Invasive Staphylococcus aureus Infection Cohort (INSTINCT) study...
March 2017: Journal of Infection
https://www.readbyqxmd.com/read/27982681/background-levels-of-neomorphic-2-hydroxyglutarate-facilitate-proliferation-of-primary-fibroblasts
#8
A Dvořák, J Zelenka, K Smolková, L Vítek, P JeŽek
Each cell types or tissues contain certain "physiological" levels of R-2-hydroxyglutarate (2HG), as well as enzymes for its synthesis and degradation. 2HG accumulates in certain tumors, possessing heterozygous point mutations of isocitrate dehydrogenases IDH1 (cytosolic) or IDH2 (mitochondrial) and contributes to strengthening their malignancy by inhibiting 2-oxoglutarate-dependent dioxygenases. By blocking histone de-methylation and 5-methyl-cytosine hydroxylation, 2HG maintains cancer cells de-differentiated and promotes their proliferation...
December 16, 2016: Physiological Research
https://www.readbyqxmd.com/read/27941763/long-term-survival-of-patients-with-cll-after-allogeneic-transplantation-a-report-from-the-european-society-for-blood-and-marrow-transplantation
#9
M van Gelder, L C de Wreede, M Bornhäuser, D Niederwieser, M Karas, N S Anderson, M Gramatzki, P Dreger, M Michallet, E Petersen, D Bunjes, M Potter, D Beelen, J J Cornelissen, I Yakoub-Agha, N H Russell, J Finke, H Schoemans, A Vitek, Á Urbano-Ispízua, D Blaise, L Volin, P Chevallier, D Caballero, H Putter, A van Biezen, A Henseler, S Schönland, N Kröger, J Schetelig
Even with the availability of targeted drugs, allogeneic hematopoietic cell transplantation (allo-HCT) is the only therapy with curative potential for patients with CLL. Cure can be assessed by comparing long-term survival of patients to the matched general population. Using data from 2589 patients who received allo-HCT between 2000 and 2010, we used landmark analyses and methods from relative survival analysis to calculate excess mortality compared with an age-, sex- and calendar year-matched general population...
December 12, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27819688/allogeneic-haematopoietic-stem-cell-transplant-in-patients-with-lower-risk-myelodysplastic-syndrome-a-retrospective-analysis-on-behalf-of-the-chronic-malignancy-working-party-of-the-ebmt
#10
M Robin, R Porcher, W Zinke-Cerwenka, A van Biezen, L Volin, G Mufti, C Craddock, J Finke, C Richard, J Passweg, A Peniket, J Maertens, G Sucak, T Gedde-Dahl, A Vitek, A Nagler, D Blaise, D Beelen, N Maillard, R Schwerdtfeger, T de Witte, N Kroger
We report a retrospective analysis of 246 myelodysplastic syndrome (MDS) patients in the EBMT (The European Society for Blood and Marrow Transplantation) database who were transplanted for International Prognostic Scoring System (IPSS) low or intermediate-1 disease. The majority of these patients (76%) were reclassified as intermediate or higher risk according to R-IPSS. The 3-year overall survival (OS) and PFS were 58% and 54%, respectively. In a multivariate analysis, adverse risk factors for PFS were marrow blast percentage (hazard ratio (HR): 1...
February 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27779246/are-patients-willing-to-incur-out-of-pocket-costs-for-pharmacogenomic-testing
#11
S J Bielinski, J L St Sauver, J E Olson, M L Wieland, C R Vitek, E J Bell, M E Mc Gree, D J Jacobson, J B McCormick, P Y Takahashi, J L Black, P J Caraballo, R R Sharp, T J Beebe, R M Weinshilboum, L Wang, V L Roger
No abstract text is available yet for this article.
January 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/27690120/discrepancy-in-vancomycin-auc-mic-ratio-targeted-attainment-based-upon-the-susceptibility-testing-in-staphylococcus-aureus
#12
Seenae Eum, Robert L Bergsbaken, Craig L Harvey, J Bryan Warren, John C Rotschafer
This study demonstrated a statistically significant difference in vancomycin minimum inhibitory concentration (MIC) for Staphylococcus aureus between a common automated system (Vitek 2) and the E-test method in patients with S. aureus bloodstream infections. At an area under the serum concentration time curve (AUC) threshold of 400 mg∙h/L, we would have reached the current Infectious Diseases Society of America (IDSA)/American Society of Health System Pharmacists (ASHP)/Society of Infectious Diseases Pharmacists (SIDP) guideline suggested AUC/MIC target in almost 100% of patients while using the Vitek 2 MIC data; however, we could only generate 40% target attainment while using E-test MIC data (p < 0...
September 27, 2016: Antibiotics
https://www.readbyqxmd.com/read/27650829/prognostic-pre-transplant-factors-in-myelodysplastic-syndromes-primarily-treated-by-high-dose-allogeneic-hematopoietic-stem-cell-transplantation-a-retrospective-study-of-the-mds-subcommittee-of-the-cmwp-of-the-ebmt
#13
E M P Cremers, A van Biezen, L C de Wreede, M Scholten, A Vitek, J Finke, U Platzbecker, D Beelen, R Schwerdtfeger, L Volin, N Harhalakis, N Blijlevens, A Nagler, N Kröger, T de Witte
Many pre-transplant factors are known to influence the outcome of allogeneic stem cell transplantation (SCT) treatment in myelodysplastic syndromes (MDS). However, patient cohorts are often heterogeneous by disease stage and treatment modalities, which complicates interpretation of the results. This study aimed to obtain a homogeneous patient cohort by including only de novo MDS patients who received upfront allogeneic SCT after standard high dose myelo-ablative conditioning. The effect of pre-transplant factors such as age, disease stage, transfusions, iron parameters and comorbidity on overall survival (OS), non-relapse mortality (NRM), and relapse incidence (RI) was evaluated in 201 patients...
December 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27643580/changes-in-liver-ganglioside-metabolism-in-obstructive-cholestasis-the-role-of-oxidative-stress
#14
V Šmíd, T Petr, K Váňová, J Jašprová, J Šuk, L Vítek, F Šmíd, L Muchová
Bile acids have been implicated in cholestatic liver damage, primarily due to their detergent effect on membranes and induction of oxidative stress. Gangliosides can counteract these harmful effects by increasing the rigidity of the cytoplasmic membrane. Induction of haem oxygenase (HMOX) has been shown to protect the liver from increased oxidative stress. The aim of this study was to determine the changes in the synthesis and distribution of liver gangliosides following bile duct ligation (BDL), and to assess the effects of HMOX both on cholestatic liver injury and ganglioside metabolism...
2016: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/27597652/treatment-of-inflammatory-arthritis-via-targeting-of-tristetraprolin-a-master-regulator-of-pro-inflammatory-gene-expression
#15
E A Ross, A J Naylor, J D O'Neil, T Crowley, M L Ridley, J Crowe, T Smallie, T J Tang, J D Turner, L V Norling, S Dominguez, H Perlman, N M Verrills, G Kollias, M P Vitek, A Filer, C D Buckley, J L Dean, A R Clark
OBJECTIVES: Tristetraprolin (TTP), a negative regulator of many pro-inflammatory genes, is strongly expressed in rheumatoid synovial cells. The mitogen-activated protein kinase (MAPK) p38 pathway mediates the inactivation of TTP via phosphorylation of two serine residues. We wished to test the hypothesis that these phosphorylations contribute to the development of inflammatory arthritis, and that, conversely, joint inflammation may be inhibited by promoting the dephosphorylation and activation of TTP...
September 5, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27539104/the-effect-of-colesevelam-treatment-on-bile-acid-and-lipid-metabolism-and-glycemic-control-in-healthy-men
#16
T Blahová, L Peterková, M Leníček, M Vlachová, K Zemánková, V Adámková, L Vítek, J Kovář
The treatment of hypercholesterolemia with bile acid (BA) sequestrants results in upregulation of BA synthesis through the classical pathway initiated by cholesterol 7alpha-hydroxylase (CYP7A1). To characterize the detailed dynamics of serum lipid and BA concentrations and the BA synthesis rate in response to treatment with BA sequestrants and to determine whether the -203A/C promoter polymorphism of the CYP7A1 encoding gene (CYP7A1) affects such a response, this pilot study was carried out in healthy men (8 homozygous for the -203A allele and 8 homozygous for the -203C allele of CYP7A1)...
December 13, 2016: Physiological Research
https://www.readbyqxmd.com/read/27454012/-correlation-between-maldi-tof-vitek-mstm-system-and-conventional-identification-methods-of-gastrointestinal-infection-causing-bacteria
#17
C Ruiz de Alegría-Puig, A Aguirre-Quiñonero, J Agüero-Balbín, M P Roiz-Mesones, L Martínez-Martínez
OBJECTIVE: Rapid identification of pathogens is essential for the diagnosis of gastrointestinal infections. Matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry has shown to be effective and fast for the identification of microorganisms. The objective of this study was to evaluate the correlation between Vitek-MSTM and conventional methods for bacterial identification causing gastrointestinal infection. METHODS: A total of 329 gastrointestinal pathogens were identified using Vitek-MSTM (v2 SARAMIS MS -ID, bioMérieux, Marcy-I´Étoile, France) and routine diagnostic methods simultaneously...
October 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/27330319/optimizing-the-detection-of-methicillin-resistant-staphylococcus-aureus-with-elevated-vancomycin-minimum-inhibitory-concentrations-within-the-susceptible-range
#18
Cameron J Phillips, Nicholas A Wells, Marianne Martinello, Simon Smith, Richard J Woodman, David L Gordon
BACKGROUND: Determination of vancomycin minimum inhibitory concentration (MIC) can influence the agent used to treat methicillin-resistant Staphylococcus aureus (MRSA) infection. We studied diagnostic accuracy using E-test and VITEK(®) 2 against a gold standard broth microdilution (BMD) methodology, the correlation between methods, and associations between vancomycin MIC and MRSA phenotype from clinical isolates. METHODS: MRSA isolates were obtained from April 2012 to December 2013...
2016: Infection and Drug Resistance
https://www.readbyqxmd.com/read/27175805/heme-oxygenase-is-not-involved-in-the-anti-proliferative-effects-of-statins-on-pancreatic-cancer-cells
#19
K Vanova, S Boukalova, H Gbelcova, L Muchova, J Neuzil, R Gurlich, T Ruml, L Vitek
BACKGROUND: Pancreatic cancer is recognized as one of the most fatal tumors due to its aggressiveness and resistance to therapy. Statins were previously shown to inhibit the proliferation of cancer cells via various signaling pathways. In healthy tissues, statins activate the heme oxygenase pathway, nevertheless the role of heme oxygenase in pancreatic cancer is still controversial. The aim of this study was to evaluate, whether anti-proliferative effects of statins in pancreatic cancer cells are mediated via the heme oxygenase pathway...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27155109/integrating-pharmacogenomics-into-clinical-practice-promise-vs-reality
#20
Jennifer L St Sauver, Suzette J Bielinski, Janet E Olson, Elizabeth J Bell, Michaela E Mc Gree, Debra J Jacobson, Jennifer B McCormick, Pedro J Caraballo, Paul Y Takahashi, Veronique L Roger, Carolyn R Rohrer Vitek
BACKGROUND: Limited information is available regarding primary care clinicians' response to pharmacogenomic clinical decision support (PGx-CDS) alerts integrated in the electronic health record. METHODS: In February 2015, 159 clinicians in the Mayo Clinic primary care practice were sent e-mail surveys to understand their perspectives on the implementation and use of pharmacogenomic testing in their clinical practice. Surveys assessed how the clinicians felt about pharmacogenomics and whether they thought electronic PGx-CDS alerts were useful...
October 2016: American Journal of Medicine
keyword
keyword
13614
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"