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https://www.readbyqxmd.com/read/29679542/treatments-for-diabetes-mellitus-type-ii-new-perspectives-regarding-the-possible-role-of-calcium-and-camp-interaction
#1
REVIEW
Diego Soares Carvalho, Alexandre Aparecido de Almeida, Aurélio Ferreira Borges, Diego Vannucci Campos
Diabetes mellitus (DM) is among the top ten causes of death worldwide. It is considered to be one of the major global epidemics of the 21st century, with a significant impact on public health budgets. DM is a metabolic disorder with multiple etiologies. Its pathophysiology is marked by dysfunction of pancreatic β-cells which compromises the synthesis and secretion of insulin along with resistance to insulin action in peripheral tissues (muscle and adipose). Subjects presenting insulin resistance in DM type 2 often also exhibit increased insulin secretion and hyperinsulinemia...
April 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29628173/-the-plague-an-overview-and-hot-topics
#2
A Galy, P Loubet, N Peiffer-Smadja, Y Yazdanpanah
Plague is a bacterial zoonosis caused by Yersinia pestis, usually found in fleas and small rodents that constitute the reservoir of the disease. It is transmitted to humans by flea bite, contact with rodents or inhalation of infected droplets. There are three clinical forms: bubonic plague, pulmonary plague and septicemic plague. The usual presentation is a flu-like syndrome possibly accompanied by an inflammatory lymphadenopathy which appears after 1 to 7days of incubation. Bubonic plague has a case fatality rate of about 50% while other forms of plague are almost always fatal without treatment...
April 5, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29627504/prioritizing-complex-disease-risk-genes-by-integrating-multiple-data
#3
Shanshan Guo, Benliang Wei, Bingchen Dong, Wan Li, Song Wu, Yuehan He, Yahui Wang, Xilei Zhao, Lina Chen, Weiming He
Complex diseases, such as obesity, type II diabetes and chronic obstructive pulmonary disease (COPD) as metabolic disorder-related diseases are major concern for worldwide public health in the 21st century. The identification of these disease risk genes has attracted increasing interest in computational systems biology. In this paper, a novel method was proposed to prioritize disease risk genes (PDRG) by integrating functional annotations, protein interactions and gene expression information to assess similarity between genes in a disease-related metabolic network...
April 5, 2018: Genomics
https://www.readbyqxmd.com/read/29605525/strengthening-the-public-health-workforce-an-estimation-of-the-long-term-requirements-for-public-health-specialists-in-serbia
#4
Milena Santric Milicevic, Milena Vasic, Matt Edwards, Cristina Sanchez, John Fellows
At the beginning of the 21st century, planning the public health workforce requirements came into the focus of policy makers. The need for improved provision of essential public health services, driven by a challenging non-communicable disease and causes of death and disability within Serbia, calls for a much needed estimation of the requirements of the public health professionals. Mid and long-term public health specialists' supply and demand estimations out to 2025were developed based on national staffing standards and regional distribution of the workforce in public health institutes of Serbia...
March 21, 2018: Health Policy
https://www.readbyqxmd.com/read/29588944/defeating-epilepsy-a-global-public-health-commitment
#5
Shekhar Saxena, Shichuo Li
This article points out that defeating epilepsy is a global public health commitment and a new challenge. This is because: epilepsy causes a heavy burden and very high treatment gap; in the field of life sciences and medicine, the 21st century would be the "Century of Brain Science"; a number of national brain research initiatives provide a great opportunity to reveal the secret of epilepsy; the Global Campaign against Epilepsy and the Mental Health Gap Action Programme made great contributions in the epilepsy control work worldwide; the historical WHA68...
June 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29559155/simple-but-not-easy-opportunities-and-challenges-from-teachers-and-students-perspectives-in-the-21st-century-of-veterinary-parasitology-teaching
#6
Christina Strube, Katharina Raue, Elisabeth Janecek
One of the main goals in academia is, and has been, high quality education of students to provide theoretical and practical knowledge essential for professional life. Achieving this goal is highly dependent on teaching procedures and, consequently, on a constant adaptation of teaching styles to align to technical advances and cutting-edge topics. Technical advances can strongly influence teaching and learning in the complex subject area of veterinary parasitology. Today's students are provided with extensive, digital lecture notes, and e-learning offers including virtual microscope technology to independently obtain intensified theoretical knowledge and understanding...
March 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29547810/entry-to-practice-public-health-nursing-competencies-a-delphi-method-and-knowledge-translation-strategy
#7
Ruth Schofield, Andrea Chircop, Cynthia Baker, Marie Dietrich Leurer, Susan Duncan, Donalda Wotton
BACKGROUND: Sustaining and strengthening nurses 'contributions to public and population health in the 21st century depends in part on nursing education. Clearly articulated entry-to-practice competencies will contribute to the capacity of undergraduate nursing education programs to prepare graduates to promote local, national and global population health. OBJECTIVES: The Canadian Association of Schools of Nursing created the Public Health Task Force to develop consensus on core, national entry-to-practice competencies in public health nursing for undergraduate nursing students and to support these competencies with corresponding online teaching strategies...
March 8, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29547371/looking-forward-to-the-next-70-years-from-a-national-ill-health-service-to-a-national-health-system
#8
David J Hunter
Amidst the NHS's (National Health Service) success lies its major weakness, although one that Klein overlooks in his reflections on the NHS as it approaches 70. The focus on, and investment in, curing ill-health has been at the expense of attending to the public's overall health and well-being. This preoccupation poses a greater threat to the NHS's future than privatisation. Despite the weakness having been diagnosed decades ago, redressing the imbalance has proved stubbornly hard to achieve. Rhetoric has not been translated into reality...
March 16, 2018: Health Economics, Policy, and Law
https://www.readbyqxmd.com/read/29544707/opioid-use-in-gynecologic-oncology-in-the-age-of-the-opioid-epidemic-part-ii-balancing-safety-accessibility
#9
REVIEW
Amin A Ramzan, Stacy Fischer, Mary K Buss, Renata R Urban, Bruce Patsner, Linda R Duska, Christine M Fisher, Carolyn Lefkowits
As the only oncologists that provide both medical and surgical care, gynecologic oncologists encounter an exceptionally broad range of indications for prescribing opioids in clinical situations ranging from management of acute post-operative pain to chronic cancer-related pain to end-of-life care. While opioids are essential to the practice of gynecologic oncology, they can also have significant side effects and can be misused. Due to the explosive growth of opioid prescriptions and opioid-related overdoses and deaths during the first decade of the 21st century, there has been a recent concerted public health effort to prevent and treat opioid misuse through both legislation and education [1]...
March 12, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29524950/human-dignity-as-leading-principle-in-public-health-ethics-a-multi-case-analysis-of-21st-century-german-health-policy-decisions
#10
Sebastian F Winter, Stefan F Winter
BACKGROUND: There is ample evidence that since the turn of the millennium German health policy made a considerable step towards prevention and health promotion, putting the strategies of 'personal empowerment' and 'settings based approach' high on the federal government's agenda. This phenomenon has challenged the role of ethics in health policy. Concurrently, increasing relevance of the Concept of Human Dignity for health and human rights has been discussed. However, a direct relationship between Human Dignity and Public Health Ethics (PHE) has surprisingly not yet been established...
June 10, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/29516447/an-agenda-for-21st-century-neurodevelopmental-medicine-lessons-from-autism
#11
A Klin, W Jones
The future of neurodevelopmental medicine has the potential of situating child neurology at the forefront of a broad-based public health effort to optimize neurodevelopmental outcomes of children born with high-prevalence and diverse genetic, pre- and peri-natal, and environmental burdens compromising early brain development and leading to lifetime disabilities. Building on advancements in developmental social neuroscience and in implementation science, this shift is already occurring in the case of emblematic neurodevelopmental disorders such as autism...
March 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29514332/availability-quality-and-relevance-of-toxicogenomics-data-for-human-health-risk-assessment-a-scoping-review-of-the-literature-on-trihalomethanes
#12
Julien Vachon, Florence Pagé-Larivière, Marc-André Sirard, Manuel J Rodriguez, Patrick Levallois, Céline Campagna
Human health risk assessment (HHRA) must be adapted to the challenges of the 21st century, and the use of toxicogenomics data in HHRA is among the changes that regulatory agencies worldwide are trying to implement. However, the use of toxicogenomics data in HHRA is still limited. The purpose of this study was to explore the availability, quality and relevance to HHRA of toxicogenomics publications as potential barriers to their use in HHRA. We conducted a scoping review of available toxicogenomics literature, using trihalomethanes as a case study...
March 5, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29506012/clinical-diagnosis-of-dental-caries-in-the-21st-century-introductory-paper-orca-saturday-afternoon-symposium-2016
#13
Vita Machiulskiene, Joana Christina Carvalho
Classifications employed to measure dental caries should first of all reflect the dynamics of the disease, in order to provide a solid basis for subsequent treatment decisions and for further monitoring of dental health of individual patients and populations. The contemporary philosophy of dental caries management implies that nonoperative treatment of caries lesions should be implemented whenever possible, limiting operative interventions to the severe and irreversible cases. The ORCA Saturday Afternoon Symposium 2016, held back-to-back to the 63rd ORCA Congress in Athens, Greece, was intended to provide an update on general requirements for clinical caries diagnosis and to overview caries diagnostic classifications including their rationale, validation, advantages, and limitations...
March 5, 2018: Caries Research
https://www.readbyqxmd.com/read/29486208/meat-in-the-post-truth-era-mass-media-discourses-on-health-and-disease-in-the-attention-economy
#14
Frédéric Leroy, Malaika Brengman, Wouter Ryckbosch, Peter Scholliers
The debate on meat's role in health and disease is a rowdy and dissonant one. This study uses the health section of the online version of The Daily Mail as a case study to carry out a quantitative and qualitative reflection on the related discourses in mass media during the first fifteen years of the 21st century. This period ranged from the fall-out of the bovine spongiform encephalopathy (BSE) crisis and its associated food safety anxieties, over the Atkins diet-craze in 2003 and the avian flu episode in 2007, to the highly influential publication of the report on colon cancer by the International Agency for Research on Cancer (IARC) in 2015...
June 1, 2018: Appetite
https://www.readbyqxmd.com/read/29485479/competency-based-time-variable-education-in-the-health-professions-crossroads
#15
Catherine R Lucey, George E Thibault, Olle Ten Cate
Health care systems around the world are transforming to align with the needs of 21st-century patients and populations. Transformation must also occur in the educational systems that prepare the health professionals who deliver care, advance discovery, and educate the next generation of physicians in these evolving systems. Competency-based, time-variable education, a comprehensive educational strategy guided by the roles and responsibilities that health professionals must assume to meet the needs of contemporary patients and communities, has the potential to catalyze optimization of educational and health care delivery systems...
March 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29448153/projecting-future-climate-change-impacts-on-heat-related-mortality-in-large-urban-areas-in-china
#16
Ying Li, Ting Ren, Patrick L Kinney, Andrew Joyner, Wei Zhang
Global climate change is anticipated to raise overall temperatures and has the potential to increase future mortality attributable to heat. Urban areas are particularly vulnerable to heat because of high concentrations of susceptible people. As the world's largest developing country, China has experienced noticeable changes in climate, partially evidenced by frequent occurrence of extreme heat in urban areas, which could expose millions of residents to summer heat stress that may result in increased health risk, including mortality...
February 12, 2018: Environmental Research
https://www.readbyqxmd.com/read/29444784/a-scoping-review-protocol-to-map-the-evidence-on-interventions-to-prevent-overweight-and-obesity-in-children
#17
Peer-Benedikt Vincent Bussiek, Chiara De Poli, Gwyn Bevan
INTRODUCTION: Obesity has become one of the biggest public health problems of the 21st century. Prevalence of obesity in children and adolescents has increased dramatically worldwide over the last 20 years, and this trend is expected to continue. Obesity in childhood is concerning as it predicts obesity in adulthood, a common risk factor for a wide array of chronic diseases and poor health outcomes. Obesity is preventable and a vast but fragmented body of evidence on preventative interventions is now available...
February 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29392186/environmental-toxicant-exposures-and-type-2-diabetes-mellitus-two-interrelated-public-health-problems-on-the-rise
#18
Marcelo G Bonini, Robert M Sargis
Rates of type 2 diabetes mellitus (T2DM) are rising rapidly across the globe and the impact of this devastating disease threatens to plague the 21st century. While some contributing factors are well-recognized (e.g. sedentary lifestyles and caloric excess), others diabetes-promoting risk factors are less established or poorly appreciated. The latter category includes environmental exposures to diabetogenic contaminants. Herein we review some of the latest concepts and mechanisms by which environmental exposures may contribute to rising rates of T2DM with a particular focus on mechanisms involving mitochondrial dysfunction and imbalances in reactive oxygen species (ROS)...
February 2018: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/29369815/marijuana-use-among-youths-in-mississippi-united-states
#19
REVIEW
Rasaki Aranmolate
Background Increased use of marijuana among youths in Mississippi, United States is of great concern to Public Health in the 21st century. This study examined the prevalence of marijuana use according to gender, race and ethnicity. Method The data for this study was obtained from Youth Risk Behavior Surveillance System (YRBSS) for 2015, a cross-sectional survey of the Mississippi High School Students, which examined the prevalence and trends in the use of marijuana according to gender, race and ethnicity. The trends in the percentage of students that reported the use of marijuana and its product was examined by univariate t-test statistical analysis at p < 0...
January 25, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29369690/antibiotic-resistance-profile-of-commensal-escherichia-coli-isolated-from-broiler-chickens-in-qatar
#20
Nahla O Eltai, Elmoubasher A Abdfarag, Hamad Al-Romaihi, Eman Wehedy, Mahmoud H Mahmoud, Osama K Alawad, Mohammed M Al-Hajri, Asmaa A Al Thani, Hadi M Yassine
Antibiotic resistance (AR) is a growing public health concern worldwide, and it is a top health challenge in the 21st century. AR among Enterobacteriaceae is rapidly increasing, especially in third-generation cephalosporins and carbapenems. Further, strains carrying mobilized colistin resistance ( mcr) genes 1 and 2 have been isolated from humans, food-producing animals, and the environment. The uncontrolled use of antibiotics in food-producing animals is a major factor in the generation and spread of AR. No studies have been done to evaluate AR in the veterinary sector of Qatar...
January 25, 2018: Journal of Food Protection
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