keyword
MENU ▼
Read by QxMD icon Read
search

Candida typing

keyword
https://www.readbyqxmd.com/read/29325080/dst659-genotype-of-candida-albicans-showing-positive-association-between-biofilm-formation-and-dominance-in-taiwan
#1
Jang-Jih Lu, Hsiu-Jung Lo, Yen-Mu Wu, Jia-Yuan Chang, Yin-Zhi Chen, Shao-Hung Wang
Based on multiple locus sequence typing, we previously found that DST659 and DST693 were dominant genotypes of Candida albicans among the bloodstream isolates at Chang-Gung Memorial Hospital at Linkou. Biofilm-forming activity, which is critical for C. albicans virulence, probably contributed to the dominance of antifungal sensitive isolates in hospital. Both in vitro membrane weighting and in vivo zebrafish egg infection assays were used to evaluate the biofilm-forming activity of DST659 and DST693 genotypes...
January 8, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29324336/new-1-5-and-2-5-disubstituted-tetrazoles-dependent-activity-towards-surface-barrier-of-candida-albicans
#2
Monika Staniszewska, Małgorzata Gizińska, Ewa Mikulak, Klaudia Adamus, Mirosława Koronkiewicz, Edyta Łukowska-Chojnacka
A series of novel tetrazole derivatives was synthetized using N-alkylation or Michael-type addition reactions, and screened for their fungistatic potential against Candida albicans (the lack of endpoint = 100%). Among them, the selected compounds 2d, 4b, and 6a differing in substituents at the tetrazole ring were non-toxic to Galleria mellonella larvae in vivo and exerted slight toxicity against Caco-2 in vitro (CC50 at 256 μg/mL). An antagonistic effect of tetrazole derivatives 2d, 4b, and 6a respectively in combination with Fluconazole was shown using the checker board and colorimetric methods (fractional inhibitory concentration indexes FICIs >1)...
December 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29318401/synthesis-anti-microbial-activity-cytotoxicity-of-some-novel-substituted-5-3-1h-benzo-d-imidazol-2-yl-4-hydroxybenzyl-benzofuran-2-yl-phenyl-methanone-analogs
#3
Bhookya Shankar, Pochampally Jalapathi, Balabadra Saikrishna, Shaym Perugu, Vijjulatha Manga
BACKGROUND: There is a dire need for the discovery and development of new antimicrobial agents after several experiments for a better resistance of microorganisms towards antimicrobial agents become a serious health problem for a few years in the past. As benzimidazole possess various types of biological activities, it has been synthesized, in the present study, a new series of (5-(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxybenzyl)benzofuran-2-yl)(phenyl)methanone analogs by using the condensation and screened for its in vitro antimicrobial activity and cytotoxicity...
January 9, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29318385/transcription-factor-network-efficiency-in-the-regulation-of-candida-albicans-biofilms-it-is-a-small-world
#4
Virginia E Glazier, Damian J Krysan
Complex biological processes are frequently regulated through networks comprised of multiple signaling pathways, transcription factors, and effector molecules. The identity of specific genes carrying out these functions is usually determined by single mutant genetic analysis. However, to understand how the individual genes/gene products function, it is necessary to determine how they interact with other components of the larger network; one approach to this is to use genetic interaction analysis. The human fungal pathogen Candida albicans regulates biofilm formation through an interconnected set of transcription factor hubs and is, therefore, an example of this type of complex network...
January 9, 2018: Current Genetics
https://www.readbyqxmd.com/read/29315506/optimization-of-voriconazole-therapy-for-the-treatment-of-invasive-fungal-infections-in-adults
#5
Naveen Mangal, Issam Hamadeh, Meghan J Arwood, Larisa H Cavallari, Tanay S Samant, Kenneth P Klinker, Jurgen Bulitta, Stephan Schmidt
Therapeutic concentrations of voriconazole in invasive fungal infections (IFIs) are ensured using drug monitoring approach, which relies on attainment of steady state pharmacokinetics. For voriconazole, time to reach steady state can vary from 5-7 days, not optimal for critically ill patients. We developed a population pharmacokinetic/pharmacodynamic model-based approach to predict doses which can maximize the net benefit (probability of efficacy - probability of adverse events) and ensure therapeutic concentrations, early on during treatment...
January 9, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29314280/fabrication-of-silver-chloride-nanoparticles-using-a-plant-serine-protease-in-combination-with-photo-activation-and-investigation-of-their-biological-activities
#6
Jaruwan Siritapetawee, Wanwisa Limphirat, Nawarat Nantapong, Dujdow Songthamwat
Recently, the development of 'green' methods for fabrication of silver nanoparticles (Ag-NPs) has been emphasized, in view of their environmental safety, feasibility and low cost. In this study, a serine protease, EuP-82 from Euphorbia cf. lactea latex, was used to fabricate silver chloride nanoparticles (AgCl-NPs) in phosphate-buffered saline (pH 7.2), under the influence of visible light. The fabricated nanoparticles had a maximal surface plasmon resonance absorption peak at 435 nm. The size of the AgCl-NPs, estimated by scanning electron microscopy, was 57 ± 14...
January 3, 2018: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29311082/deletion-of-ada2-increases-antifungal-drug-susceptibility-and-virulence-in-candida-glabrata
#7
Shang-Jie Yu, Ya-Lin Chang, Ying-Lien Chen
Candida glabrata, the second most frequent cause of candidiasis after Candida albicans, is an emerging human fungal pathogen that is intrinsically drug tolerant. Currently, studies of C. glabrata genes involved in drug tolerance are limited. Ada2, a component serving as a transcription adaptor of the Spt-Ada-Gcn5 acetyltransferase (SAGA) complex, is required for antifungal drug tolerance and virulence in C. albicans However, its roles in C. glabrata remain elusive. In this study, we found that ada2 mutants demonstrated severe growth defects at 40°C but only mild defects at 37°C or 25°C...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29311063/mutant-prevention-concentration-and-mutant-selection-window-of-micafungin-and-anidulafungin-in-clinical-candida-glabrata-isolates
#8
María Ángeles Bordallo-Cardona, Laura Judith Marcos-Zambrano, Carlos Sánchez-Carrillo, Elia Gómez G de la Pedrosa, Rafael Cantón, Emilio Bouza, Pilar Escribano, Jesús Guinea
Background: We report the mutant prevention concentration (MPC) and mutant selection window (MSW) for micafungin and anidulafungin administered to treat Candida glabrata We also determine the mutation frequency.Methods: We studied 20 echinocandin-susceptible, fluconazole-intermediate, and FKS wild-type C. glabrata isolates. Adjusted inocula were stroked directly onto Sabouraud agar plates containing different concentrations of micafungin or anidulafungin and visually inspected daily for up to 5 days of incubation...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29306553/knockout-of-autophagy-gene-atg5-in-mice-vaginal-cells-abrogates-cytokine-response-and-pathogen-clearance-during-vaginal-infection-of-candida-albicans
#9
Ankit Shroff, Roicy Sequeira, Vainav Patel, K V R Reddy
The female reproductive tract (FRT) presents a unique challenge to the mucosal immune system as it needs to monitor constantly for the presence of opportunistic pathogens amidst its commensal flora. During infection, autophagy plays a critical role in pathogen clearance, presentation of antigens and production of pro-inflammatory cytokines. However, no information is available that describes the role of autophagy in mouse vaginal infection of Candida albicans. The objective of our study is to evaluate the effect of autophagy gene, ATG5 knockout in vaginal cells in response to vaginal C...
December 28, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29305843/circulating-microparticles-levels-are-increased-in-patients-with-diabetic-kidney-disease-a-case-control-research
#10
Kathryna Fontana Rodrigues, Nathalia Teixeira Pietrani, Ana Paula Fernandes, Adriana Aparecida Bosco, Maira Cândida Rodrigues de Sousa, Ieda de Fátima Oliveira Silva, Josianne Nicácio Silveira, Fernanda Magalhães Freire Campos, Karina Braga Gomes
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with chronic lowgrade inflammation. Microparticles (MPs) are extracellular microvesicles released during apoptosis and cellular activation. The MP's pro-coagulant and pro-inflammatory activities are involved in endothelial dysfunction observed in T2DM patients. This study aimed to evaluate the circulating MPs profile in T2DM patients with diabetic kidney disease (DKD) and correlate it with clinical and laboratorial parameters. METHODS: MPs derived from platelets (PMPs), leukocytes (LMPs), endothelial cells (EMPs), and expressing tissue factor (TFMPs) were measured by flow cytometry, in plasma of 39 DKD patients and 30 non-diabetic controls...
January 3, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29303754/surface-treatment-of-implant-materials-with-antimicrobial-nanoparticulates
#11
Nathalia Ferraz Oliscovicz, Denise Tornavoi de Castro, Mariana Lima da Costa Valente, Evandro Watanabe, César Penazzo Lepri, Andréa Cândido Dos Reis
This study analyzed nanostructured silver vanadate (AgVO3) films on certain substrate surfaces found in dental implant devices in order to see if these films promote antimicrobial activity. Enamel and glaze vehicles were used to apply the nanomaterial (0.0% [control], 2.5%, 5.0%, and 10.0% concentrations) on 3 substrates (280 specimens per substrate): polytetrafluoroethylene (PTFE), polyacetal, and acrylic resin. An agar diffusion method was performed in triplicate to determine the antimicrobial activity against 8 microorganisms...
January 2018: General Dentistry
https://www.readbyqxmd.com/read/29274093/interactions-between-candida-albicans-and-candida-glabrata-in-biofilms-influence-of-the-strain-type-culture-medium-and-glucose-supplementation
#12
Thayse Yumi Hosida, Thamires Priscila Cavazana, Mariana Henriques, Juliano Pelim Pessan, Alberto Carlos Botazzo Delbem, Douglas Roberto Monteiro
The relationship among Candida species may be influenced by several factors. Thus, this study evaluated the interactions between Candida albicans and Candida glabrata in biofilms, varying the strain type, culture medium and glucose supplementation. Biofilms were formed for 48 h in SDB or RPMI 1640, supplemented with 0, 1 or 5% glucose. Each strain of C. albicans was combined with two strains of C. glabrata, generating 4 biofilm associations, which were quantified by colony-forming units (CFUs), total biomass and metabolic activity...
December 23, 2017: Mycoses
https://www.readbyqxmd.com/read/29261697/microbial-cells-can-cooperate-to-resist-high-level-chronic-ionizing-radiation
#13
Igor Shuryak, Vera Y Matrosova, Elena K Gaidamakova, Rok Tkavc, Olga Grichenko, Polina Klimenkova, Robert P Volpe, Michael J Daly
Understanding chronic ionizing radiation (CIR) effects is of utmost importance to protecting human health and the environment. Diverse bacteria and fungi inhabiting extremely radioactive waste and disaster sites (e.g. Hanford, Chernobyl, Fukushima) represent new targets of CIR research. We show that many microorganisms can grow under intense gamma-CIR dose rates of 13-126 Gy/h, with fungi identified as a particularly CIR-resistant group of eukaryotes: among 145 phylogenetically diverse strains tested, 78 grew under 36 Gy/h...
2017: PloS One
https://www.readbyqxmd.com/read/29250064/p17-an-original-host-defense-peptide-from-ant-venom-promotes-antifungal-activities-of-macrophages-through-the-induction-of-c-type-lectin-receptors-dependent-on-ltb4-mediated-ppar%C3%AE-activation
#14
Khaddouj Benmoussa, Hélène Authier, Mélissa Prat, Mohammad AlaEddine, Lise Lefèvre, Mouna Chirine Rahabi, José Bernad, Agnès Aubouy, Elsa Bonnafé, Jérome Leprince, Bernard Pipy, Michel Treilhou, Agnès Coste
Despite the growing knowledge with regard to the immunomodulatory properties of host defense peptides, their impact on macrophage differentiation and on its associated microbicidal functions is still poorly understood. Here, we demonstrated that the P17, a new cationic antimicrobial peptide from ant venom, induces an alternative phenotype of human monocyte-derived macrophages (h-MDMs). This phenotype is characterized by a C-type lectin receptors (CLRs) signature composed of mannose receptor (MR) and Dectin-1 expression...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29248721/the-3-phenylcoumarin-derivative-6-7-dihydroxy-3-3-4-methylenedioxyphenyl-coumarin-downmodulates-the-fc%C3%AE-r-and-cr-mediated-oxidative-metabolism-and-elastase-release-in-human-neutrophils-possible-mechanisms-underlying-inhibition-of-the-formation-and-release-of
#15
Micássio F Andrade, Luciana M Kabeya, Leandro O Bortot, Gabriela B Dos Santos, Everton O L Santos, Lucinéia R Albiero, Andréa S G Figueiredo-Rinhel, Camila A Carvalho, Ana Elisa C S Azzolini, Antonio Caliri, Mônica T Pupo, Flávio S Emery, Yara Maria Lucisano-Valim
In this study, we report the ability of a set of eight 3-phenylcoumarin derivatives bearing 6,7- or 5,7-dihydroxyl groups, free or acetylated, bound to the benzopyrone moiety, to modulate the effector functions of human neutrophils. In general, (i) 6,7-disubstituted compounds (5, 6, 19, 20) downmodulated the Fcγ receptor-mediated neutrophil oxidative metabolism more strongly than 5,7-disubstituted compounds (21, 22, 23, 24), and (ii) hydroxylated compounds (5, 19, 21, 23) downmodulated this neutrophil function more effectively than their acetylated counterparts (6, 20, 22, 24, respectively)...
December 14, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29244019/prevalence-healthcare-resource-utilization-and-overall-burden-of-fungal-meningitis-in-the-united-states
#16
Lefko T Charalambous, Alykhan Premji, Caroline Tybout, Anastasia Hunt, Drew Cutshaw, Aladine A Elsamadicy, Siyun Yang, Jichun Xie, Charles Giamberardino, Promila Pagadala, John R Perfect, Shivanand P Lad
PURPOSE: Previous epidemiological and cost studies of fungal meningitis have largely focused on single pathogens, leading to a poor understanding of the disease in general. We studied the largest and most diverse group of fungal meningitis patients to date, over the longest follow-up period, to examine the broad impact on resource utilization within the United States. METHODOLOGY: The Truven Health Analytics MarketScan database was used to identify patients with a fungal meningitis diagnosis in the United States between 2000 and 2012...
December 15, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29242451/world-catalogue-of-the-druid-flies-diptera-schizophora-clusiidae
#17
Owen Lonsdale
Family-, genus- and species-level groups in the family Clusiidae (Diptera: Schizophora) are catalogued, providing reference to occurrences of these taxa in the literature, including all those relevant to nomenclature. Full synonymies are provided, including generic combinations for species, and the collection locality, depository and sex of primary type specimens. Published species distributions are provided, noting country and biogeographic region; specimen data representing new country records for species are listed...
October 12, 2017: Zootaxa
https://www.readbyqxmd.com/read/29228797/in-situ-microstructure-and-rheological-behavior-of-yeast-biofilms-from-the-juice-processing-industries
#18
María C Tarifa, Diego Genovese, Jorge E Lozano, Lorena I Brugnoni
The factors affecting the mechanical properties of biofilms formed by yeast species (Rhodotorula mucilaginosa, Candida krusei, C. kefyr and C. tropicalis) isolated from the juice processing industries have been investigated. Variables studied were: the food matrix (apple/pear juice), the sugar concentration (6/12 °Bx) and the hydrodynamic conditions (static/turbulent flow). A range of environmental cues were included as the mechanical properties of biofilms are complex. Yeast counts were significantly higher in turbulent flow compared with under static conditions...
December 12, 2017: Biofouling
https://www.readbyqxmd.com/read/29228268/low-and-constant-micafungin-concentrations-may-be-sufficient-to-lead-to-resistance-mutations-in-fks2-gene-of-candida-glabrata
#19
María Ángeles Bordallo-Cardona, Pilar Escribano, Laura Judith Marcos-Zambrano, Judith Díaz-García, Elia Gómez de la Pedrosa, Rafael Cantón, Emilio Bouza, Jesús Guinea
We studied the ability of five echinocandin-susceptible C. glabrata isolates to acquire in vitro resistance to anidulafungin and micafungin. All isolates became phenotypically resistant after 2-4 days of exposure to low and constant micafungin concentrations (P < .05). Mutations in the HS1 region of the FKS2 gene were found in all isolates. The acquisition of resistance was not related to the previous use of antifungal treatment in the patients or the presence of mutations at MSH2 gene. We found differences (P < ...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29225105/interpretation-of-b-type-natriuretic-peptides-in-the-era-of-angiotensin-receptor-neprilysin-inhibitors
#20
Paulo Bettencourt, Cândida Fonseca, Fátima Franco, Aurora Andrade, Dulce Brito
Assessment of serum levels of natriuretic peptides, especially the amino-terminal portion (NT-proBNP) and the carboxy-terminal portion (BNP) of pro-B-type natriuretic peptide, has had a highly significant clinical impact on the diagnosis and prognostic stratification of patients with heart failure (HF). They are now an instrument with recognized value in this context and several studies have demonstrated their value in tailoring therapy for these patients. Following the recent advent of angiotensin receptor-neprilysin inhibitors (ARNIs), there is a need to review how these two biomarkers are interpreted in HF...
December 7, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
keyword
keyword
13610
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"