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Candida parapsilosis

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https://www.readbyqxmd.com/read/28527136/factors-influencing-non-albicans-candidemia-a-case-case-control-study
#1
Diamantis P Kofteridis, Antonis Valachis, Dimitra Dimopoulou, Angeliki M Andrianaki, Athanasia Christidou, Sofia Maraki, Nikolaos A Spernovasilis, George Samonis
The study identified factors predisposing to non-albicans candidemia with special interest to prior antimicrobial treatment. A retrospective, case-case-control study was performed at the University Hospital of Heraklion, Greece, from November 2007 through September 2011 including adult patients. The study had three groups. The first included 58 patients with non-albicans candidemia, the second 48 with C. albicans candidemia, while the third (control) 104 without candidemia. Each of the two candidemia groups was compared with the control using multivariate logistic regression model...
May 19, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28523422/usefulness-of-the-non-conventional-caenorhabditis-elegans-model-to-assess-candida-virulence
#2
Marcelo Ortega-Riveros, Iker De-la-Pinta, Cristina Marcos-Arias, Guillermo Ezpeleta, Guillermo Quindós, Elena Eraso
Invasive candidiasis is caused mainly by Candida albicans, but other Candida species have increasing etiologies. These species show different virulence and susceptibility levels to antifungal drugs. The aims of this study were to evaluate the usefulness of the non-conventional model Caenorhabditis elegans to assess the in vivo virulence of seven different Candida species and to compare the virulence in vivo with the in vitro production of proteinases and phospholipases, hemolytic activity and biofilm development capacity...
May 18, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28511380/fungal-profile-of-vulvovaginal-candidiasis-in-a-tertiary-care-hospital
#3
Krishnapriya Kalaiarasan, Rakesh Singh, Latha Chaturvedula
INTRODUCTION: Vulvovaginal Candidiasis (VVC) is a common medical health problem of adult women. It is most commonly caused by Candida albicans. But there is a change in fungal profile. Sabouraud's Dextrose Agar (SDA) is the most common culture medium used where mixed fungal infection may be missed. It can be detected easily by using chromogenic culture medium. AIM: To know the fungal profile of vulvovaginal candidiasis using Candida CHROMagar and antifungal susceptibility pattern in patients attending tertiary care hospital...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28506251/diversity-in-vitro-virulence-traits-and-antifungal-susceptibility-pattern-of-gastrointestinal-yeast-flora-of-healthy-poultry-gallus-gallus-domesticus
#4
Supram Hosuru Subramanya, Nawal Kishor Sharan, Bharat Prasad Baral, Deependra Hamal, Niranjan Nayak, Peralam Yegneswaran Prakash, Brijesh Sathian, Indira Bairy, Shishir Gokhale
BACKGROUND: Poultry farming and consumption of poultry (Gallus gallus domesticus) meat and eggs are common gastronomical practices worldwide. Till now, a detailed understanding about the gut colonisation of Gallus gallus domesticus by yeasts and their virulence properties and drug resistance patterns in available literature remain sparse. This study was undertaken to explore this prevalent issue. RESULTS: A total of 103 specimens of fresh droppings of broiler chickens (commercial G domesticus) and domesticated chickens (domesticated G domesticus) were collected from the breeding sites...
May 15, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28486529/ag-i-camphorimine-complexes-with-antimicrobial-activity-towards-clinically-important-bacteria-and-species-of-the-candida-genus
#5
João M S Cardoso, Soraia I Guerreiro, Andreia Lourenço, Marta M Alves, M Fátima Montemor, Nuno P Mira, Jorge H Leitão, M Fernanda N N Carvalho
The present work follows a previous report describing the antibacterial activity of silver camphorimine complexes of general formula [Ag(NO3)L]. The synthesis and demonstration of the antifungal and antibacterial activity of three novel [Ag(NO3)L] complexes (named 1, 2 and 3) is herein demonstrated. This work also shows for the first time that the previously studied complexes (named 4 to 8) also exert antifungal activity. The antibacterial activity of complexes was evaluated against Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia contaminans and Escherichia coli strains, while antifungal activity was tested against the Candida species C...
2017: PloS One
https://www.readbyqxmd.com/read/28483957/candida-parapsilosis-sensu-lato-in-pediatric-patients-identification-of-cryptic-species-and-antifungal-susceptibility-testing
#6
Maria Emilia Cattana, Catiana Dudiuk, Mariana Fernández, Florencia Rojas, Liliana Alegre, Susana Córdoba, Guillermo García-Effron, Gustavo Giusiano
A total of 59 C. parapsilosis sensu stricto and 1 C. orthopsilosis recovered from catheters and blood cultures of pediatric patients of the Northeastern region of Argentina were studied. Susceptibility to azoles, amphotericin B, and echinocandins were tested by broth microdilution method. According to CLSI clinical breakpoints, more than 91% of the strains were azole-susceptible while 15% showed high amphotericin B MICs.
May 8, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28459966/efficacy-of-anidulafungin-in-539-patients-with-invasive-candidiasis-a-patient-level-pooled-analysis-of-six-clinical-trials
#7
Bart Jan Kullberg, José Vasquez, Piroon Mootsikapun, Marcio Nucci, José-Artur Paiva, Jorge Garbino, Jean Li Yan, Jalal Aram, Maria Rita Capparella, Umberto Conte, Haran Schlamm, Robert Swanson, Raoul Herbrecht
Objectives: To evaluate the efficacy of anidulafungin for the treatment of candidaemia and invasive candidiasis in a large dataset, including patients with deep-seated tissue candidiasis, neutropenia and infection due to non- albicans Candida species. Methods: Data were pooled from six prospective, multicentre, multinational studies: four open-label, non-comparative studies of anidulafungin and two double-blind, double-dummy, randomized studies of anidulafungin versus caspofungin (clinical trial registrations: NCT00496197, NCT00548262, NCT00537329, NCT00689338, NCT00806351 and NCT00805740; ClinicalTrials...
April 28, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28458871/candida-parapsilosis-associated-with-cervical-necrotizing-fasciitis-and-descending-mediastinitis
#8
Chung-Ching Lee, Wing-Kei Choi, Jimmy Yu-Wai Chan
BACKGROUND: This report presents an immunocompetent lady suffering from Candida parapsilosis associated with polybacterial cervical necrotizing fasciitis and descending mediastinitis. A literature review and management of invasive candidiasis is discussed. METHODS: A 57-year-old healthy lady presented with cervical necrotizing fasciitis and descending mediastinitis. She was promptly managed with emergency debridement. Both blood and tissue culture yielded multiple microorganisms including C...
April 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28457646/-molecular-identification-and-in-vitro-antifungal-susceptibility-of-blood-isolates-of-the-candida-parapsilosis-species-complex-in-venezuela
#9
Xiomara Moreno, Vera Reviakina, María M Panizo, Giusseppe Ferrara, Nataly García, Víctor Alarcón, María F Garcés, Maribel Dolande
BACKGROUND: Candida parapsilosis is a species complex consisting of Candida parapsilosis sensu stricto, Candida orthopsilosis, and Candida metapsilosis. Studies worldwide have described its epidemiology and susceptibility to antifungal agents. AIMS: The aims of this study were to carry out the molecular identification of blood isolates belonging to the Candida parapsilosis species complex, and to determine their in vitro susceptibility to antifungals of systemic use...
April 27, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28440822/a-carbonyl-reductase-from-candida-parapsilosis-atcc-7330-substrate-selectivity-and-enantiospecificity
#10
Sneha Sudhakara, Anju Chadha
Candida parapsilosis ATCC 7330, a rich source of highly stereospecific oxidoreductases, catalyzes oxidation-reduction of a plethora of compounds yielding industrially important intermediates. An (S)-specific carbonyl reductase (SRED) purified and characterized from this yeast is reported here. (R)-Specific carbonyl reductase (CpCR) was reported by us earlier. SRED asymmetrically reduces ketones with excellent enantiospecificity (ee > 99%) and α-ketoesters with higher catalytic activity but moderate enantiospecificity (ee 70%) in the presence of NADPH...
May 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28434558/resistance-profiles-and-risk-factors-of-resistant-microorganisms-in-bacteraemia-of-abdominal-origin
#11
J Martín Jaramago, R Armero Ibáñez, J J Camarena Miñana, M Morales Suárez-Varela
OBJECTIVE: The presence of resistant microorganisms is a major cause of failure in initial empirical antimicrobial therapy. The objectives of this study are to determine the resistance profile of microorganisms that cause bacteraemia of abdominal origin and to identify whether the previous use of antibiotics and the place of acquisition of bacteraemia are risk factors associated with the presence of resistant organisms. MATERIAL AND METHODS: A clinical, observational, epidemiological, retrospective cohort study was conducted with all the adult patients admitted to a university hospital from 2011-2013...
April 20, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28421398/supradescemetic-voriconazole-injection-for-candida-parapsilosis-keratitis
#12
Nikolaos Mamas, Konstantinos Andreanos, Klio Chatzistefanou, Petros Petrou, Dimitrios Brouzas, George Kymionis, Chrysanthi Koutsandrea, Konstantinos Droutsas
PURPOSE: To describe a technique for intracorneal application of voriconazole into the supradescemetic space in a case of deep recalcitrant Candida parapsilosis keratitis of a penetrating cornea graft. METHODS: A deep intracorneal incision reaching the center of the corneal infiltrate was created with a 20-gauge MVR blade. Then, a 27-gauge hydrodissection cannula was inserted deep into the corneal pocket, and 0.1 ml of voriconazole 0.5 mg/ml was injected until a bullous detachment of Descemet membrane (DM) covered 1/3 of the graft's area...
April 18, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28419092/a-multi-centric-study-of-candida-bloodstream-infection-in-lima-callao-peru-species-distribution-antifungal-resistance-and-clinical-outcomes
#13
MULTICENTER STUDY
Lourdes Rodriguez, Beatriz Bustamante, Luz Huaroto, Cecilia Agurto, Ricardo Illescas, Rafael Ramirez, Alberto Diaz, Jose Hidalgo
BACKGROUND: The incidence of candidemia is increasing in developing countries. Very little is known about the epidemiology of candidemia in Peru. The aim of this study is to describe the incidence, microbiology, clinical presentation and outcomes of Candida bloodstream infections in three Lima-Callao hospitals. METHODS: Candida spp. isolates were identified prospectively at participant hospitals between November 2013 and January 2015. Susceptibility testing for amphotericin B, fluconazole, posaconazole, voriconazole and anidulafungin was performed using broth microdilution method...
2017: PloS One
https://www.readbyqxmd.com/read/28418628/catheter-related-fungal-endocarditis-caused-by-candida-parapsilosis-in-a-hemodialysis-patient
#14
Ying Shu, Shaobin Yu, Ling Zha, Ping Fu, Tianlei Cui
Fungal endocarditis (FE) is commonly regarded as a rare but fatal disease. The incidence of infective endocarditis (IE) in hemodialysis (HD) patients is thought to be obviously higher than that in the general population. Moreover, IE occurs more likely in HD patients with catheters. With the increase of HD population and extensive use of catheters in HD patients, FE, as a special form of IE, may increase and bring new challenges to clinicians. We reported a case of FE associated with catheter infection in a 44-year-old woman on HD...
April 18, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28417524/biofilms-of-candida-spp-from-the-ocular-conjunctiva-of-horses-with-reduced-azole-susceptibility-a-complicating-factor-for-the-treatment-of-keratomycosis
#15
Raimunda Sâmia Nogueira Brilhante, Paula Vago Bittencourt, Débora de Souza Collares Castelo-Branco, Glaucia Morgana de Melo Guedes, Jonathas Sales de Oliveira, Lucas Pereira Alencar, Rossana de Aguiar Cordeiro, Mariana Pinheiro, Evilázio Fernandes Nogueira-Filho, Waldemiro de Aquino Pereira-Neto, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
OBJECTIVES: This study aimed to assess the biofilm-forming ability of Candida spp. from the ocular conjunctiva of horses and to investigate the antifungal susceptibility of these biofilms. PROCEDURES: Initially, the biofilm-forming ability of 15 strains was assessed by crystal violet staining, which reveals the fungal biomass adhered to the polystyrene plates, and scanning electron microscopy. Then, the minimum inhibitory concentrations (MICs) of amphotericin B, fluconazole, itraconazole, and caspofungin were initially determined against strains in planktonic form...
April 18, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28415502/antimicrobial-textiles-biogenic-silver-nanoparticles-against-candida-and-xanthomonas
#16
Daniela Ballottin, Stephanie Fulaz, Flávia Cabrini, Junko Tsukamoto, Nelson Durán, Oswaldo L Alves, Ljubica Tasic
This paper introduces cotton fibers impregnated with biogenic silver nanoparticles (AgNPs), synthesized from a Fusarium oxysporum fungal filtrate (FF) solution, and open up the possibility for their use in medical environment and agriculture clothing as means to avoid microbial spreading. After thorough AgNPs characterization, regarding their physical, chemical and biochemical properties, Minimum Inhibitory Concentrations (MIC) against some human and orange tree pathogens were determined. We report the strong AgNPs activity against Candida parapsilosis and Xanthomonas axonopodis pv...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28409296/silver-i-complexes-with-chromone-derived-hydrazones-investigation-on-the-antimicrobial-and-cytotoxic-effects
#17
Lenka V Tamayo, Ane F Santos, Isabella P Ferreira, Verlane G Santos, Miriam T P Lopes, Heloisa Beraldo
Complexes [Ag(HCrPh)2]NO3·2H2O (1) and [Ag(HCrpClPh)2]NO3 (2) were obtained with 3-formyl-6-methylchromone-phenyl hydrazone (HCrPh, HL1) and 3-formyl-6-methylchromone-para-chloro-phenyl hydrazone (HCrpClPh, HL2). Although the hydrazones were inactive, upon coordination to silver(I) antifungal activity significantly improved against several Candida strains. Complexes (1-2) revealed to be more active than silver nitrate, silver sulfadiazine and the reference drug nystatin against Candida parapsilosis. The cytotoxic activities of the hydrazones and their silver(I) complexes were evaluated in comparison with cisplatin on B16F10 (metastatic melanoma) and Melan-a (non-tumorigenic melanocyte) cells...
June 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28400000/influence-of-growth-conditions-on-adhesion-of-yeast-candida-spp-and-pichia-spp-to-stainless-steel-surfaces
#18
Ružica Tomičić, Peter Raspor
An understanding of adhesion behavior of Candida and Pichia yeast under different environmental conditions is key to the development of effective preventive measures against biofilm-associated infection. Hence in this study we investigated the impact of growth medium and temperature on Candida and Pichia adherence using stainless steel (AISI 304) discs with different degrees of surface roughness (Ra = 25.20-961.9 nm), material typical for the food processing industry as well as medical devices. The adhesion of the yeast strains to stainless steel surfaces grown in Malt Extract broth (MEB) or YPD broth at three temperatures (7 °C, 37 °C, 43 °C for Candida strains and 7 °C, 27 °C, 32 °C for Pichia strains) was assessed by crystal violet staining...
August 2017: Food Microbiology
https://www.readbyqxmd.com/read/28396240/identification-of-proteins-involved-in-the-adhesionof-candida-species-to-different-medical-devices
#19
Arianna Núñez-Beltrán, Everardo López-Romero, Mayra Cuéllar-Cruz
Adhesion is the first step for Candida species to form biofilms on medical devices implanted in the human host. Both the physicochemical nature of the biomaterial and cell wall proteins (CWP) of the pathogen play a determinant role in the process. While it is true that some CWP have been identified in vitro, little is known about the CWP of pathogenic species of Candida involved in adhesion. On this background, we considered it important to investigate the potential role of CWP of C. albicans, C. glabrata, C...
April 7, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28394977/-clinical-and-epidemiological-changes-of-candidemia-among-adult-patients-from-2000-to-2013
#20
Leonardo Siri, Paulette Legarraga, Patricia García, Tamara González, Ricardo Rabagliati
BACKGROUND: Invasive Candida spp. infections have been described more frequently. AIM: To characterize the epidemiological data of candidemia in recent years. METHODS: A retrospective study of adult patients in a University Hospital in Santiago, Chile, with 1 or more documented episodes of candidemia, from January 2000 to December 2013. RESULTS: One hundred and twenty episodes of candidemia were identified in 120 patients, annual incidence of 0...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
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