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Candida parapsilosis

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https://www.readbyqxmd.com/read/29330691/bis-guanylhydrazones-as-efficient-anti-candida-compounds-through-dna-interaction
#1
Jelena Lazić, Vladimir Ajdačić, Sandra Vojnovic, Mario Zlatović, Marina Pekmezovic, Selene Mogavero, Igor Opsenica, Jasmina Nikodinovic-Runic
Candida spp. are leading causes of opportunistic mycoses, including life-threatening hospital-borne infections, and novel antifungals, preferably aiming targets that have not been used before, are constantly needed. Hydrazone- and guanidine-containing molecules have shown a wide range of biological activities, including recently described excellent antifungal properties. In this study, four bis-guanylhydrazone derivatives (BG1-4) were generated following a previously developed synthetic route. Anti-Candida (two C...
January 12, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29310582/identification-of-uncommon-oral-yeasts-from-cancer-patients-by-maldi-tof-mass-spectrometry
#2
Narges Aslani, Ghasem Janbabaei, Mahdi Abastabar, Jacques F Meis, Mahasti Babaeian, Sadegh Khodavaisy, Teun Boekhout, Hamid Badali
BACKGROUND: Opportunistic infections due to Candida species occur frequently in cancer patients because of their inherent immunosuppression. The aim of the present study was to investigate the epidemiology of yeast species from the oral cavity of patients during treatment for oncological and haematological malignancies. METHODS: MALDI-TOF was performed to identify yeasts isolated from the oral cavity of 350 cancer patients. Moreover, antifungal susceptibility testing was performed in according to CLSI guidelines (M27-A3)...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29302624/chemical-composition-and-antifungal-effect-of-hydroalcoholic-extract-of-allium-tripedale-tvautv-against-candida-species
#3
M Shirani, A Samimi, H Kalantari, M Madani, A Kord Zanganeh
Background and Purpose: Treatment of life-threatening fungal infections caused by Candida species has become a major problem. Candida spp. are the most important causative agents of candidiasis. Allium tripedale is a medicinal plant that has been traditionally used to treat infections. In the present study, we aimed to determine the chemical compounds and antimicrobial activity of hydroalcoholic extract of A. tripedale against different species of Candida. Materials and Methods: Phytochemical analysis was performed to identify the possible bioactive components of this extract by using gas chromatography and mass spectroscopy (GC-MS)...
March 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29287632/association-between-candida-biofilm-forming-bloodstream-isolates-and-the-clinical-evolution-in-patients-with-candidemia-an-observational-nine-year-single-center-study-in-mexico
#4
Rogelio de J Treviño-Rangel, Cynthia D Peña-López, Pedro A Hernández-Rodríguez, Dinael Beltrán-Santiago, Gloria M González
BACKGROUND: Candidemia is one of the most common nosocomial infections globally and it is associated with considerable excess mortality and costs. Abreast, biofilm-forming strains are associated with even higher mortality rates and poor prognosis for the patient. AIMS: To evaluate a possible association between the biofilm-forming capability of Candida bloodstream isolates and the clinical evolution in patients with candidemia. METHODS: An observational, retrospective study was conducted at a tertiary care university hospital during 9 years (2006-2015)...
December 26, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29274492/the-synthesis-antifungal-and-apoptotic-effects-of-triazole-oxadiazoles-against-candida-species
#5
Betül Kaya Çavuşoğlu, Leyla Yurttaş, Zerrin Cantürk
In search of potent and safe antifungal agents, herein, we report the synthesis, characterization and biological activities of triazole-oxadiazole compounds. The structural verification of the molecules was carried out by 1H NMR, 13C NMR and mass spectral data. The in vitro antifungal and apoptotic activity were investigated against C. albicans, C. parapsilosis, C. krusei and C. glabrata. The compounds namely N-(4-nitrophenyl)-2-[(5-(2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)ethyl)-1,3,4-oxadiazol-2-yl)thio]acetamide (4e) and N-(6-fluorobenzothiazol-2-yl)-2-[(5-(2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)ethyl)-1,3,4-oxadiazol-2-yl)thio]acetamide (4i) were detected as the most potent compounds against C...
December 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29261697/microbial-cells-can-cooperate-to-resist-high-level-chronic-ionizing-radiation
#6
Igor Shuryak, Vera Y Matrosova, Elena K Gaidamakova, Rok Tkavc, Olga Grichenko, Polina Klimenkova, Robert P Volpe, Michael J Daly
Understanding chronic ionizing radiation (CIR) effects is of utmost importance to protecting human health and the environment. Diverse bacteria and fungi inhabiting extremely radioactive waste and disaster sites (e.g. Hanford, Chernobyl, Fukushima) represent new targets of CIR research. We show that many microorganisms can grow under intense gamma-CIR dose rates of 13-126 Gy/h, with fungi identified as a particularly CIR-resistant group of eukaryotes: among 145 phylogenetically diverse strains tested, 78 grew under 36 Gy/h...
2017: PloS One
https://www.readbyqxmd.com/read/29228397/yeast-identification-by-sequencing-biochemical-kits-maldi-tof-ms-and-rep-pcr-dna-fingerprinting
#7
Ying Zhao, Chi-Ching Tsang, Meng Xiao, Jasper F W Chan, Susanna K P Lau, Fanrong Kong, Yingchun Xu, Patrick C Y Woo
No study has comprehensively evaluated the performance of 28S nrDNA and ITS sequencing, commercial biochemical test kits, MALDI-TOF MS platforms, and the emerging rep-PCR DNA fingerprinting technology using a cohort of yeast strains collected from a clinical microbiology laboratory. In this study, using 71 clinically important yeast isolates (excluding Candida albicans) collected from a single centre, we determined the concordance of 28S nrDNA and ITS sequencing and evaluated the performance of two commercial test kits, two MALDI-TOF MS platforms, and rep-PCR DNA fingerprinting...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29209074/in-vitro-and-in-vivo-antifungal-activities-and-mechanism-of-heteropolytungstates-against-candida-species
#8
Han Li, Hongwei Gong, Yanfei Qi, Juan Li, Xufeng Ji, Jiaheng Sun, Rui Tian, Hao Bao, Xiangfu Song, Qiang Chen, Guoliang Liu
The antifungal activities of heteropolytungstates, α-1,2,3-K6H[SiW9V3O40] (SiW-3), K13[Ce(SiW11O39)2]·17H2O (SiW-5), K13[Eu(SiW11O39)2]·25H2O (SiW-10), K6PV3W9O40 (PW-6), α-K4PVW11O40 (PW-8), were screened in 29 Candida albicans, 8 Candida glabrata, 3 Candida krusei, 2 Candida parapsilosis, 1 Candida tropicalis, and 1 Cryptococcus neoformans strains using the CLSI M27-A3 method. SiW-5 had the highest efficacy with a minimum inhibitory concentration (MIC) values of <0.2-10.2 μM in vitro. The antifungal mechanism, acute toxicity and in vivo antifungal activity of SiW-5 were then evaluated in C...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29206226/merging-ft-ir-and-ngs-for-simultaneous-phenotypic-and-genotypic-identification-of-pathogenic-candida-species
#9
Claudia Colabella, Laura Corte, Luca Roscini, Volha Shapaval, Achim Kohler, Valeria Tafintseva, Carlo Tascini, Gianluigi Cardinali
The rapid and accurate identification of pathogen yeast species is crucial for clinical diagnosis due to the high level of mortality and morbidity induced, even after antifungal therapy. For this purpose, new rapid, high-throughput and reliable identification methods are required. In this work we described a combined approach based on two high-throughput techniques in order to improve the identification of pathogenic yeast strains. Next Generation Sequencing (NGS) of ITS and D1/D2 LSU marker regions together with FTIR spectroscopy were applied to identify 256 strains belonging to Candida genus isolated in nosocomial environments...
2017: PloS One
https://www.readbyqxmd.com/read/29200950/isolation-and-determination-of-four-potential-antimicrobial-components-from-pseudomonas-aeruginosa-extracts
#10
Ling-Qing Xu, Jian-Wen Zeng, Chong-He Jiang, Huan Wang, Yu-Zhen Li, Wei-Hong Wen, Jie-Hua Li, Feng Wang, Wei-Jen Ting, Zi-Yong Sun, Chih-Yang Huang
Background:Pseudomonas aeruginosa can cause disease and also can be isolated from the skin of healthy people. Additionally, it exhibits certain antimicrobial effects against other microorganisms.Methods: We collected 60 strains of P. aeruginosa and screened their antimicrobial effects against Staphylococcus aureus (ATCC 25923) using the filter paper-disk method, the cross-streaking method and the co-culture method and then evaluated the antimicrobial activity of the chloroform-isolated S. aureus extracts against methicillin-resistant S...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29199660/a-study-of-changes-in-the-oral-fungal-flora-of-patients-on-radiotherapy-for-head-and-neck-malignancies-and-their-correlation-with-funguria-and-fungemia
#11
S Raj, D Sharma, P Mate, M R Capoor, K T Bhowmik
BACKGROUND: Patients of head and neck malignancies often develop oral mucositis and invite various pathogens to colonize over it. OBJECTIVES: The objective of this study is to identify the fungi isolated from patients undergoing radiotherapy (RT) for head and neck cancer, to determine the antifungal susceptibility of these isolates and to determine the time and week of fungal colonization. PATIENTS AND METHODS: Three specimens (throat, urine, and blood) were collected from each of the head and neck cancer patients, who were advised RT...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29195956/different-inoculation-methods-for-semi-dry-processed-coffee-using-yeasts-as-starter-cultures
#12
Silvia Juliana Martinez, Ana Paula Pereira Bressani, Maria Gabriela da Cruz Pedrozo Miguel, Disney Ribeiro Dias, Rosane Freitas Schwan
This study evaluates the behavior of Saccharomyces (S.) cerevisiae (CCMA 0543), Candida (C.) parapsilosis (CCMA 0544), and Torulaspora (T.) delbrueckii (CCMA 0684) as starter cultures for semi-dry processed coffee using two inoculation methods: (1) direct inoculation and (2) bucket inoculation. The microbial population was evaluated by plating and real-time polymerase chain reaction (qPCR). The microbial metabolic changes of both bucket and direct inoculation methods during fermentation were evaluated using high performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC-MS)...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29184547/zinc-limitation-induces-a-hyper-adherent-goliath-phenotype-in-candida-albicans
#13
Dhara Malavia, Laura E Lehtovirta-Morley, Omran Alamir, Elisabeth Weiß, Neil A R Gow, Bernhard Hube, Duncan Wilson
Pathogenic microorganisms often face acute micronutrient limitation during infection due to the action of host-mediated nutritional immunity. The human fungal pathogen Candida albicans is polymorphic and its morphological plasticity is one of its most widely recognized pathogenicity attributes. Here we investigated the effect of zinc, iron, manganese, and copper limitation on C. albicans morphology. Restriction of zinc specifically resulted in the formation of enlarged, spherical yeasts, a phenotype which we term Goliath cells...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29183771/comparative-study-for-147-candida-spp-identification-and-echinocandins-susceptibility-in-isolates-obtained-from-blood-cultures-in-15-hospitals-medellin-colombia
#14
Indira Berrio, Natalia Maldonado, Catalina De Bedout, Karen Arango, Luz Elena Cano, Yorlady Valencia, Cristina Jiménez-Ortigosa, David S Perlin, Beatriz L Gómez, Carlos Robledo, Jaime Robledo
INTRODUCTION: Invasive candidiasis has high impact on morbidity and mortality in hospitalized patients. Accurate and timely methods for identification of Candida species and determination of equinocandins susceptibility become a priority for laboratories of clinical microbiology. METHODS: A study was performed to compare MALDI-TOF MS identification to sequencing of D1/D2 region of rRNA gene complex 28 subunit, in 147 isolates obtained from patients with candidemia...
November 25, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29180990/the-n-terminus-of-human-lactoferrin-displays-anti-biofilm-activity-on-candida-parapsilosis-in-lumen-catheters
#15
Roberta Fais, Mariagrazia Di Luca, Cosmeri Rizzato, Paola Morici, Daria Bottai, Arianna Tavanti, Antonella Lupetti
Candida parapsilosis is a major cause of hospital-acquired infection, often related to parenteral nutrition administered via catheters and hand colonization of health care workers, and its peculiar biofilm formation ability on plastic surfaces. The mortality rate of 30% points to the pressing need for new antifungal drugs. The present study aimed at analyzing the inhibitory activity of the N-terminal lactoferrin-derived peptide, further referred to as hLF 1-11, against biofilms produced by clinical isolates of C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29173584/candida-parapsilosis-complex-in-veterinary-practice-a-historical-overview-biology-virulence-attributes-and-antifungal-susceptibility-traits
#16
REVIEW
Rossana de Aguiar Cordeiro, Jamille Alencar Sales, Débora de Souza Collares Maia Castelo-Branco, Raimunda Samia Nogueira Brilhante, Yago Brito de Ponte, Géssica Dos Santos Araújo, Patrícia Bruna Leite Mendes, Vandbergue Santos Pereira, Lucas Pereira de Alencar, Adriana de Queiroz Pinheiro, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
The Candida genus is composed by yeast that commensally live as part of human and animal microbiota. In the last years, C. parapsilosis complex, composed by the cryptic species C. parapsilosis sensu stricto, C. orthopsilosis and C. metapsilosis, has been frequently implicated in human nosocomial infections in Europe and Latin America. In veterinary medicine, C. parapsilosis sensu lato infections have been reported in different animal species. Several putative virulence factors have been associated with the pathogenicity of this species complex, including biofilm formation and the production of proteases, phospholipases, lipases and other hydrolytic enzymes...
December 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29147867/population-structure-of-candida-parapsilosis-no-genetic-difference-between-french-and-urugayan-isolates-using-microsatellite-length-polymorphism
#17
Marie Desnos-Ollivier, Victoria Bórmida, Philippe Poirier, Céline Nourrisson, Dinorah Pan, Stéphane Bretagne, Andrès Puime, Françoise Dromer
Candida parapsilosis is a human commensal yeast, frequently involved in infection worldwide and especially in neonates. It is the second species responsible for bloodstream infections in Uruguay and the third species in France. We were interested in knowing whether the population structure of isolates responsible for candidemia in France and in Uruguay was different. Genotyping methods based on microsatellite length polymorphism (MLP) have been described and are especially used for investigation of local outbreaks...
November 16, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29142743/anti-candida-activity-of-antimicrobial-impregnated-central-venous-catheters
#18
L Cobrado, A Silva-Dias, M M Azevedo, A Rodrigues
Background: Whenever the rate of central line-associated bloodstream infections (CLABSIs) remains high even after the implementation of preventive strategies, the use of chlorhexidine/silver sulfadiazine (CSS) or minocycline/rifampin (MR)-impregnated central venous catheters (CVCs) is currently recommended. Nevertheless, the efficacy of such CVCs against Candida albicans and other emerging non-albicans spp. has been insufficiently studied. This study aims to compare the activity of CSS and MR-impregnated CVCs against the yeasts most frequently isolated from CLABSIs...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29133157/microbiological-and-clinical-characteristics-of-biofilm-forming-candida-parapsilosis-isolates-associated-with-fungaemia-and-their-impact-on-mortality
#19
Silvia Soldini, Brunella Posteraro, Antonietta Vella, Elena De Carolis, Elisa Borghi, Monica Falleni, Angela Raffaella Losito, Giuseppe Maiuro, Enrico Maria Trecarichi, Maurizio Sanguinetti, Mario Tumbarello
OBJECTIVES: Biofilm formation (BF) by fungal isolates may dramatically complicate infection. We determined the ability of C. parapsilosis isolates from single fungaemia episodes to form biofilms and we analysed biofilm subgroups for antifungal susceptibility and pathogenic potential. We then correlated BF with clinical characteristics and outcomes of the episodes. METHODS: BF was measured using the crystal-violet biomass assay, antifungal susceptibility of preformed biofilms was assessed, and virulence was studied using the Galleria mellonella model...
November 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29132935/risk-factors-and-outcomes-of-candidemia-caused-by-candida-parapsilosis-complex-in-a-medical-center-in-northern-taiwan
#20
Yen-Mu Wu, Po-Yen Huang, Jang-Jih Lu, Shian-Sen Shie, Jung-Jr Ye, Ting-Shu Wu, Ching-Tai Huang
To investigate the risk factors and outcomes associated with Candida parapsilosis candidemia, a retrospective study was conducted at a tertiary medical center in northern Taiwan. Patients with C. parapsilosis candidemia and corresponding controls with C. albicans candidemia were chosen and their demographics, comorbidities, risk factors, and clinical outcomes were reviewed. Antifungal susceptibility tests were performed using the Sensititre YeastOne colorimetric system. Matrix-assisted laser desorption ionization-time of flight mass spectrometry was used to classify the genomic species...
October 6, 2017: Diagnostic Microbiology and Infectious Disease
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