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Candida parapsilosis

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https://www.readbyqxmd.com/read/28434558/resistance-profiles-and-risk-factors-of-resistant-microorganisms-in-bacteraemia-of-abdominal-origin
#1
J Martín Jaramago, R Armero Ibáñez, J J Camarena Miñana, M Morales Suárez-Varela
OBJECTIVE: The presence of resistant microorganisms is a major cause of failure in initial empirical antimicrobial therapy. The objectives of this study are to determine the resistance profile of microorganisms that cause bacteraemia of abdominal origin and to identify whether the previous use of antibiotics and the place of acquisition of bacteraemia are risk factors associated with the presence of resistant organisms. MATERIAL AND METHODS: A clinical, observational, epidemiological, retrospective cohort study was conducted with all the adult patients admitted to a university hospital from 2011-2013...
April 20, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28421398/supradescemetic-voriconazole-injection-for-candida-parapsilosis-keratitis
#2
Nikolaos Mamas, Konstantinos Andreanos, Klio Chatzistefanou, Petros Petrou, Dimitrios Brouzas, George Kymionis, Chrysanthi Koutsandrea, Konstantinos Droutsas
PURPOSE: To describe a technique for intracorneal application of voriconazole into the supradescemetic space in a case of deep recalcitrant Candida parapsilosis keratitis of a penetrating cornea graft. METHODS: A deep intracorneal incision reaching the center of the corneal infiltrate was created with a 20-gauge MVR blade. Then, a 27-gauge hydrodissection cannula was inserted deep into the corneal pocket, and 0.1 ml of voriconazole 0.5 mg/ml was injected until a bullous detachment of Descemet membrane (DM) covered 1/3 of the graft's area...
April 18, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28419092/a-multi-centric-study-of-candida-bloodstream-infection-in-lima-callao-peru-species-distribution-antifungal-resistance-and-clinical-outcomes
#3
Lourdes Rodriguez, Beatriz Bustamante, Luz Huaroto, Cecilia Agurto, Ricardo Illescas, Rafael Ramirez, Alberto Diaz, Jose Hidalgo
BACKGROUND: The incidence of candidemia is increasing in developing countries. Very little is known about the epidemiology of candidemia in Peru. The aim of this study is to describe the incidence, microbiology, clinical presentation and outcomes of Candida bloodstream infections in three Lima-Callao hospitals. METHODS: Candida spp. isolates were identified prospectively at participant hospitals between November 2013 and January 2015. Susceptibility testing for amphotericin B, fluconazole, posaconazole, voriconazole and anidulafungin was performed using broth microdilution method...
2017: PloS One
https://www.readbyqxmd.com/read/28418628/catheter-related-fungal-endocarditis-caused-by-candida-parapsilosis-in-a-hemodialysis-patient
#4
Ying Shu, Shaobin Yu, Ling Zha, Ping Fu, Tianlei Cui
Fungal endocarditis (FE) is commonly regarded as a rare but fatal disease. The incidence of infective endocarditis (IE) in hemodialysis (HD) patients is thought to be obviously higher than that in the general population. Moreover, IE occurs more likely in HD patients with catheters. With the increase of HD population and extensive use of catheters in HD patients, FE, as a special form of IE, may increase and bring new challenges to clinicians. We reported a case of FE associated with catheter infection in a 44-year-old woman on HD...
April 18, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28417524/biofilms-of-candida-spp-from-the-ocular-conjunctiva-of-horses-with-reduced-azole-susceptibility-a-complicating-factor-for-the-treatment-of-keratomycosis
#5
Raimunda Sâmia Nogueira Brilhante, Paula Vago Bittencourt, Débora de Souza Collares Castelo-Branco, Glaucia Morgana de Melo Guedes, Jonathas Sales de Oliveira, Lucas Pereira Alencar, Rossana de Aguiar Cordeiro, Mariana Pinheiro, Evilázio Fernandes Nogueira-Filho, Waldemiro de Aquino Pereira-Neto, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
OBJECTIVES: This study aimed to assess the biofilm-forming ability of Candida spp. from the ocular conjunctiva of horses and to investigate the antifungal susceptibility of these biofilms. PROCEDURES: Initially, the biofilm-forming ability of 15 strains was assessed by crystal violet staining, which reveals the fungal biomass adhered to the polystyrene plates, and scanning electron microscopy. Then, the minimum inhibitory concentrations (MICs) of amphotericin B, fluconazole, itraconazole, and caspofungin were initially determined against strains in planktonic form...
April 18, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28415502/antimicrobial-textiles-biogenic-silver-nanoparticles-against-candida-and-xanthomonas
#6
Daniela Ballottin, Stephanie Fulaz, Flávia Cabrini, Junko Tsukamoto, Nelson Durán, Oswaldo L Alves, Ljubica Tasic
This paper introduces cotton fibers impregnated with biogenic silver nanoparticles (AgNPs), synthesized from a Fusarium oxysporum fungal filtrate (FF) solution, and open up the possibility for their use in medical environment and agriculture clothing as means to avoid microbial spreading. After thorough AgNPs characterization, regarding their physical, chemical and biochemical properties, Minimum Inhibitory Concentrations (MIC) against some human and orange tree pathogens were determined. We report the strong AgNPs activity against Candida parapsilosis and Xanthomonas axonopodis pv...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28409296/silver-i-complexes-with-chromone-derived-hydrazones-investigation-on-the-antimicrobial-and-cytotoxic-effects
#7
Lenka V Tamayo, Ane F Santos, Isabella P Ferreira, Verlane G Santos, Miriam T P Lopes, Heloisa Beraldo
Complexes [Ag(HCrPh)2]NO3·2H2O (1) and [Ag(HCrpClPh)2]NO3 (2) were obtained with 3-formyl-6-methylchromone-phenyl hydrazone (HCrPh, HL1) and 3-formyl-6-methylchromone-para-chloro-phenyl hydrazone (HCrpClPh, HL2). Although the hydrazones were inactive, upon coordination to silver(I) antifungal activity significantly improved against several Candida strains. Complexes (1-2) revealed to be more active than silver nitrate, silver sulfadiazine and the reference drug nystatin against Candida parapsilosis. The cytotoxic activities of the hydrazones and their silver(I) complexes were evaluated in comparison with cisplatin on B16F10 (metastatic melanoma) and Melan-a (non-tumorigenic melanocyte) cells...
April 13, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28400000/influence-of-growth-conditions-on-adhesion-of-yeast-candida-spp-and-pichia-spp-to-stainless-steel-surfaces
#8
Ružica Tomičić, Peter Raspor
An understanding of adhesion behavior of Candida and Pichia yeast under different environmental conditions is key to the development of effective preventive measures against biofilm-associated infection. Hence in this study we investigated the impact of growth medium and temperature on Candida and Pichia adherence using stainless steel (AISI 304) discs with different degrees of surface roughness (Ra = 25.20-961.9 nm), material typical for the food processing industry as well as medical devices. The adhesion of the yeast strains to stainless steel surfaces grown in Malt Extract broth (MEB) or YPD broth at three temperatures (7 °C, 37 °C, 43 °C for Candida strains and 7 °C, 27 °C, 32 °C for Pichia strains) was assessed by crystal violet staining...
August 2017: Food Microbiology
https://www.readbyqxmd.com/read/28396240/identification-of-proteins-involved-in-the-adhesionof-candida-species-to-different-medical-devices
#9
Arianna Núñez-Beltrán, Everardo López-Romero, Mayra Cuéllar-Cruz
Adhesion is the first step for Candida species to form biofilms on medical devices implanted in the human host. Both the physicochemical nature of the biomaterial and cell wall proteins (CWP) of the pathogen play a determinant role in the process. While it is true that some CWP have been identified in vitro, little is known about the CWP of pathogenic species of Candida involved in adhesion. On this background, we considered it important to investigate the potential role of CWP of C. albicans, C. glabrata, C...
April 7, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28394977/-clinical-and-epidemiological-changes-of-candidemia-among-adult-patients-from-2000-to-2013
#10
Leonardo Siri, Paulette Legarraga, Patricia García, Tamara González, Ricardo Rabagliati
BACKGROUND: Invasive Candida spp. infections have been described more frequently. AIM: To characterize the epidemiological data of candidemia in recent years. METHODS: A retrospective study of adult patients in a University Hospital in Santiago, Chile, with 1 or more documented episodes of candidemia, from January 2000 to December 2013. RESULTS: One hundred and twenty episodes of candidemia were identified in 120 patients, annual incidence of 0...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28382297/candida-parapsilosis-protects-premature-intestinal-epithelial-cells-from-invasion-and-damage-by-candida-albicans
#11
Sara Gonia, Linda Archambault, Margaret Shevik, Marie Altendahl, Emily Fellows, Joseph M Bliss, Robert T Wheeler, Cheryl A Gale
Candida is a leading cause of late-onset sepsis in premature infants and is thought to invade the host via immature or damaged epithelial barriers. We previously showed that the hyphal form of Candida albicans invades and causes damage to premature intestinal epithelial cells (pIECs), whereas the non-hyphal Candida parapsilosis, also a fungal pathogen of neonates, has less invasion and damage abilities. In this study, we investigated the potential for C. parapsilosis to modulate pathogenic interactions of C...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28378240/candida-albicans-germ-tube-antibody-evaluation-of-a-new-automatic-assay-for-diagnosing-invasive-candidiasis-in-icu-patients
#12
Manuel Parra-Sánchez, Ismail Zakariya-Yousef Breval, Carmen Castro Méndez, Silvia García-Rey, Ana Loza Vazquez, Alejandro Úbeda Iglesias, Desiree Macías Guerrero, Ana Romero Mejías, Cristobal León Gil, Estrella Martín-Mazuelos
Testing for Candida albicans germ-tube antibody IFA IgG assay (CAGTA) is used to detect invasive candidiasis infection. However, most suitable assays lack automation and rapid single-sample testing. The CAGTA assay was adapted in an automatic monotest system (invasive candidiasis [CAGTA] VirClia(®) IgG monotest (VirClia(®)), a chemiluminescence assay with ready-to-use reagents that provides a rapid objective result. CAGTA assay was compared with the monotest automatic VirClia(®) assay in order to establish the diagnostic reliability, accuracy, and usefulness of this method...
April 4, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28377868/a-case-of-breakthrough-candida-parapsilosis-fungemia-during-micafungin-therapy-for-a-candida-glabrata-bloodstream-infection
#13
Yuta Norimatsu, Daiichi Morii, Asako Kogure, Taeko Hamanaka, Yoshihiro Kuwano, Takayuki Yokozawa, Toshimi Oda
We describe a case of breakthrough Candida parapsilosis fungemia in an 80-year-old woman with pyoderma gangrenosum and rheumatoid arthritis. C. parapsilosis was detected in blood culture while the patient was treated with micafungin for a Candida glabrata bloodstream infection. The breakthrough infection was successfully treated with liposomal amphotericin B.
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28373148/evaluation-of-the-in-vitro-activity-of-isavuconazole-and-comparator-voriconazole-against-2635-contemporary-clinical-candida-and-aspergillus-isolates
#14
K M T Astvad, R K Hare, M C Arendrup
OBJECTIVE: The in vitro activity of isavuconazole was determined for 1677 Candida and 958 Aspergillus isolates from 2012-2014 with voriconazole as comparator. METHODS: Aspergillus isolates were screened for resistance using azole-agar. Screening positive Aspergillus and all Candida isolates underwent EUCAST broth-microdilution testing. Isolates were categorised as wild-type (wt) or non-wt, adopting EUCAST ECOFFs (where available) or wt upper limits (wtULs; two 2-fold dilutions above the MIC50)...
March 31, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28370198/diclofenac-based-hydrazones-and-spirothiazolidinones-synthesis-characterization-and-antimicrobial-properties
#15
Ayşe Kocabalkanlı, Gökçe Cihan-Üstündağ, Lieve Naesens, Emel Mataracı-Kara, Mebble Nassozi, Gültaze Çapan
We report here the synthesis, structural characterization, and biological evaluation of novel diclofenac-based hydrazone (4a-f) and spirothiazolidinone (5a-f, 6a-f) derivatives designed as potential antimicrobial agents. The compounds were evaluated in vitro for their antiviral activity against a wide spectrum of DNA and RNA viruses. They were further screened in vitro against different strains of bacteria and fungi. The hydrazone derivatives, 4a and 4c-f, were found to be active against herpesviruses (HSV-1, HSV-2, and HSV-1 TK(-) ), vaccinia virus, and Coxsackie B4 virus, with EC50 values between 6...
March 30, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28368268/candida-blood-stream-infection-in-neonates-experience-from-a-tertiary-care-teaching-hospital-of-central-india
#16
Sriparna Basu Alam, Rajesh Kumar Mahfuz, Ragini Tilak Munirul Islam, Ashok Kumar Mondal
OBJECTIVE: To assess the epidemiology of neonatal Candida blood stream infection. METHODS: Medical records of neonates with Candida blood stream infection over five years (September 2010 to August 2015) were reviewed. Clinical details, species distribution and antifungal susceptibility were noted. RESULTS: 114 neonates developed Candida blood stream infection. Commonly isolated Candida species were C. tropicalis, C. albicans and C. parapsilosis...
March 29, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28364558/changing-epidemiology-of-candidaemia-in-australia
#17
Belinda Chapman, Monica Slavin, Debbie Marriott, Catriona Halliday, Sarah Kidd, Ian Arthur, Narin Bak, Christopher H Heath, Karina Kennedy, C Orla Morrissey, Tania C Sorrell, Sebastian van Hal, Caitlin Keighley, Emma Goeman, Neil Underwood, Krispin Hajkowicz, Ann Hofmeyr, Michael Leung, Nenad Macesic, Jeannie Botes, Christopher Blyth, Louise Cooley, C Robert George, Pankaja Kalukottege, Alison Kesson, Brendan McMullan, Robert Baird, Jennifer Robson, Tony M Korman, Stella Pendle, Kerry Weeks, Eunice Liu, Elaine Cheong, Sharon Chen
Objectives: Knowledge of contemporary epidemiology of candidaemia is essential. We aimed to identify changes since 2004 in incidence, species epidemiology and antifungal susceptibilities of Candida spp. causing candidaemia in Australia. Methods: These data were collected from nationwide active laboratory-based surveillance for candidaemia over 1 year (within 2014-2015). Isolate identification was by MALDI-TOF MS supplemented by DNA sequencing. Antifungal susceptibility testing was performed using Sensititre YeastOne™...
April 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28361527/clinical-presentation-of-candidaemia-in-elderly-patients-experience-in-a-single-institution
#18
A Lerma, E Cantero, M Soriano, B Orden, E Muñez, A Ramos-Martinez
OBJECTIVE: To analyse the clinical presentation of candidaemia in elderly patients. METHODS: A comparison of clinical presentation of candidaemia cases was carried out in a Spanish tertiary hospital between January 2010 and September 2015. RESULTS: Forty-five cases (32%) corresponded to elderly patients (≥ 75 years) and 95 cases (68%) to non-elderly patients (16-74 years). A higher proportion of elderly patients presented solid tumour (51% versus 32%, p=0...
March 31, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28361459/distribution-and-antifungal-susceptibility-of-yeasts-isolates-from-intensive-care-unit-patients
#19
Vladimír Hrabovský, Victoria Takáčová, Eva Schréterová, Lydia Pastvová, Zuzana Hrabovská, Katarina Čurová, Leonard Siegfried
Yeasts frequently colonize non-sterile sites in the body. The aim of the study was to determine distribution in clinical samples and antifungal susceptibility to five antifungals. From January 2013 through June 2015, 800 isolates were obtained from intensive care unit patients. Candida albicans (58.9%), Candida glabrata (20.4%), Candida krusei (8.6%), and Candida parapsilosis (3.6%) were the leading species. Majority of the C. albicans isolates were susceptible to the fluconazole. Elevated voriconazole minimal inhibitory concentrations (MICs) were observed in isolates exhibiting high fluconazole MICs, most frequently in C...
March 30, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28359611/risk-factors-characteristics-and-outcomes-of-candidemia-in-an-adult-intensive-care-unit-in-turkey
#20
Elif Tukenmez Tigen, Huseyin Bilgin, Hande Perk Gurun, Arzu Dogru, Beste Ozben, Nilgun Cerikcioglu, Volkan Korten
Thirty-six patients with candidemia and 37 control patients were included consecutively to determine the characteristics of candidemia episodes. The patients with candidemia had higher mortality with higher Sequential Organ Failure Assessment scores and frequency of use of a central venous catheter, total parenteral nutrition, and broad-spectrum antibiotics; chronic renal failure with replacement therapy; and longer stay in an intensive care unit. Candida albicans was the predominant species followed by Candida glabrata, Candida tropicalis, and Candida parapsilosis...
March 27, 2017: American Journal of Infection Control
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