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Candida drug resistance

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https://www.readbyqxmd.com/read/27927053/future-therapies-targeted-towards-eliminating-candida-biofilms-and-associated-infections
#1
H M H N Bandara, V H Matsubara, L P Samaranayake
Candida species are common human commensals and cause either superficial or invasive opportunistic infections. The biofilm form of Candida as opposed to its suspended, planktonic form, is predominantly associated with these infections. Alternative or adjunctive therapies are urgently needed to manage Candida infections as the currently available short arsenal of antifungal drugs has been compromised due to their systemic toxicity, cross-reactivity with other drugs, and above all, by the emergence of drug-resistant Candida species due to irrational drug use...
December 7, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27917162/activity-of-scorpion-venom-derived-antifungal-peptides-against-planktonic-cells-of-candida-spp-and-cryptococcus-neoformans-and-candida-albicans-biofilms
#2
Fernanda Guilhelmelli, Nathália Vilela, Karina S Smidt, Marco A de Oliveira, Alice da Cunha Morales Álvares, Maria C L Rigonatto, Pedro H da Silva Costa, Aldo H Tavares, Sônia M de Freitas, André M Nicola, Octávio L Franco, Lorena da Silveira Derengowski, Elisabeth F Schwartz, Márcia R Mortari, Anamélia L Bocca, Patrícia Albuquerque, Ildinete Silva-Pereira
The incidence of fungal infections has been increasing in the last decades, while the number of available antifungal classes remains the same. The natural and acquired resistance of some fungal species to available therapies, associated with the high toxicity of these drugs on the present scenario and makes an imperative of the search for new, more efficient and less toxic therapeutic choices. Antimicrobial peptides (AMPs) are a potential class of antimicrobial drugs consisting of evolutionarily conserved multifunctional molecules with both microbicidal and immunomodulatory properties being part of the innate immune response of diverse organisms...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27915303/candida-species-isolated-from-different-body-sites-and-their-antifungal-susceptibility-pattern-cross-analysis-of-candida-albicans-and-candida-glabrata-biofilms
#3
Valentina Cataldi, Emanuela Di Campli, Paolo Fazii, Tonino Traini, Luigina Cellini, Mara Di Giulio
Candida species are regular commensal in humans, but-especially in immunocompromised patients-they represent opportunistic pathogens giving rise to systemic infection. The aim of the present work was to isolate and characterize for their antifungal profile Candida species from different body sites and to analyze the biofilms produced by C. albicans and C. glabrata isolates. Eighty-one strains of Candida species from 77 patients were identified. Epidemiological study showed that the most isolated species were C...
December 2, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27904062/promising-therapies-for-fungal-infection-based-on-the-study-to-elucidate-mechanisms-to-cope-with-stress-in-candida-species
#4
Kazuyuki Hirai, Tatsuya Inukai, Hironobu Nakayama
In recent years, the incidence of fungal infections has been increasing, particularly among patients with immune systems compromised by human immunodeficiency virus infection, organ transplantation, and/or chemotherapy for cancer. Current therapies for treating systemic fungal infection have limited effectiveness and have created problems of adverse reactions and drug resistance. These issues therefore motivate us to develop novel antifungals. Elucidation of stress response mechanisms and virulence factors in pathogenic fungi is required in developing an effective antifungal strategy...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27895625/evaluation-of-virulence-factors-in-vitro-resistance-to-osmotic-stress-and-antifungal-susceptibility-of-candida-tropicalis-isolated-from-the-coastal-environment-of-northeast-brazil
#5
Diana L Zuza-Alves, Sayama S T Q de Medeiros, Luanda B F C de Souza, Walicyranison P Silva-Rocha, Elaine C Francisco, Maria C B de Araújo, Reginaldo G Lima-Neto, Rejane P Neves, Analy S de Azevedo Melo, Guilherme M Chaves
Several studies have been developed regarding human health risks associated with the recreational use of beaches contaminated with domestic sewage. These wastes contain various micro-organisms, including Candida tropicalis. In this context, the objective of this study was to characterize C. tropicalis isolates from the sandy beach of Ponta Negra, Natal, Rio Grande do Norte, Brazil, regarding the expression of in vitro virulence factors, adaptation to osmotic stress and susceptibility to antifungal drugs. We analyzed 62 environmental isolates and observed a great variation among them for the various virulence factors evaluated...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27889440/non-heat-shock-responsive-roles-of-hsf1-in-candida-albicans-are-essential-under-iron-deprivation-and-drug-defense
#6
Remya Nair, Mohd Shariq, Sanjiveeni Dhamgaye, Chinmay K Mukhopadhyay, Shamim Shaikh, Rajendra Prasad
Recently, we have reported that the conditional mutant of the heat shock factor-1 (HSF1) in Candida albicans displays enhanced susceptibility not only towards a plant alkaloid, berberine, but also to diverse antifungal drugs. The present study attempts to identify additional phenotypes highlighting the non-heat shock responsive roles of HSF1 that could be correlated with the enhanced drug susceptibility. We uncover an intricate relationship between cellular iron and HSF1 mediated drug susceptibility of C. albicans...
November 24, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27881617/can-a-multi-drug-resistant-candida-auris-be-reliably-identified-in-clinical-microbiology-laboratories
#7
Masako Mizusawa, Heather Miller, Rachel Green, Richard Lee, Mariann Durante, Rosalie Perkins, Caroline Hewitt, Patricia J Simner, Karen C Carroll, Randall T Hayden, Sean X Zhang
Candida auris, an emerging multi-drug resistant yeast associated with high mortality, has been increasingly reported from outside of the US to cause outbreaks in the hospital settings (1).….
November 23, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27880665/the-current-treatment-landscape-candidiasis
#8
Matteo Bassetti, Maddalena Peghin, Jean-Francois Timsit
The epidemiology of Candida species infection has changed over recent decades, influenced by local hospital-related factors, patient predisposing conditions and type of antifungal agents administered. A shift from Candida albicans as the predominant pathogen towards an increasing prevalence of the species Candida glabrata and Candida parapsilosis amongst critically ill patients has been documented. Changes in Candida species distribution may impact treatment recommendations due to differences in susceptibility to antifungal agents among species...
November 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27879678/new-thiazolyl-triazole-schiff-bases-synthesis-and-evaluation-of-the-anti-candida-potential
#9
Anca Stana, Alexandra Enache, Dan Cristian Vodnar, Cristina Nastasă, Daniela Benedec, Ioana Ionuț, Cezar Login, Gabriel Marc, Ovidiu Oniga, Brîndușa Tiperciuc
In the context of the dangerous phenomenon of fungal resistance to the available therapies, we present here the chemical synthesis of a new series of thiazolyl-triazole Schiff bases B1-B15, which were in vitro assessed for their anti-Candida potential. Compound B10 was found to be more potent against Candida spp. when compared with the reference drugs Fluconazole and Ketoconazole. A docking study of the newly synthesized Schiff bases was performed, and results showed good binding affinity in the active site of co-crystallized Itraconazole-lanosterol 14α-demethylase isolated from Saccharomyces cerevisiae...
November 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27870871/functional-genomic-analysis-of-candida-albicans-adherence-reveals-a-key-role-for-the-arp2-3-complex-in-cell-wall-remodelling-and-biofilm-formation
#10
Jason A Lee, Nicole Robbins, Jinglin L Xie, Troy Ketela, Leah E Cowen
Fungal biofilms are complex, structured communities that can form on surfaces such as catheters and other indwelling medical devices. Biofilms are of particular concern with Candida albicans, one of the leading opportunistic fungal pathogens of humans. C. albicans biofilms include yeast and filamentous cells that are surrounded by an extracellular matrix, and they are intrinsically resistant to antifungal drugs such that resolving biofilm infections often requires surgery to remove the contaminated device. C...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27868254/extensive-functional-redundancy-in-the-regulation-of-candida-albicans-drug-resistance-and-morphogenesis-by-lysine-deacetylases-hos2-hda1-rpd3-and-rpd31
#11
Xinliu Li, Nicole Robbins, Teresa R O'Meara, Leah E Cowen
Current treatment efforts for fungal infections are hampered by the limited availability of antifungal drugs and by the emergence of drug resistance. A powerful strategy to enhance the efficacy of antifungal drugs is to inhibit the molecular chaperone Hsp90. Hsp90 governs drug resistance, morphogenesis, and virulence in a leading fungal pathogen of humans, Candida albicans. Our previous work with Saccharomyces cerevisiae established acetylation as a novel mechanism of posttranslational control of Hsp90 function in fungi...
November 21, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27855078/echinocandin-resistance-in-candida-spp-isolated-from-liver-transplant-recipients
#12
Gwénolé Prigent, Nawel Aït-Ammar, Eric Levesque, Arnaud Fekkar, Jean-Marc Costa, Sarra El Anbassi, Françoise Foulet, Christophe Duvoux, Jean-Claude Merle, Eric Dannaoui, Françoise Botterel
Liver transplant recipients are at risk of invasive fungal infections, especially candidiasis. Echinocandin is recommended as prophylactic treatment but is increasingly associated with resistance. Our aim was to assess echinocandin drug resistance in Candida spp. isolated from liver transplant recipients treated with this antifungal class. For this, all liver-transplanted patients in a University Hospital (Créteil, France) between January and June of 2013 and 2015 were included. Susceptibilities of Candida isolates to echinocandins were tested by Etest® and EUCAST reference method...
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27853524/recent-advances-on-candida-albicans-biology-and-virulence
#13
REVIEW
Adnane Sellam, Malcolm Whiteway
Candida albicans is an important human fungal pathogen, in terms of both its clinical significance and its use as an experimental model for scientific investigation. Although this opportunistic pathogen is a natural component of the human flora, it can cause life-threatening infections in immunosuppressed patients. There are currently a limited number of antifungal molecules and drug targets, and increasing resistance to the front-line therapeutics, demonstrating a clear need for new antifungal drugs. Understanding the biology of this pathogen is an important prerequisite for identifying new drug targets for antifungal therapeutics...
2016: F1000Research
https://www.readbyqxmd.com/read/27845294/-antibiotic-sensitivity-resistance-of-microbial-strains-isolated-in-traumatological-department
#14
N Avazashvili, P Imnadze, I Mchedlishvili, Kh Gachechiladze
In this article, there are given data of study for antibiotic sensitivity/resistance of gram-positive and gram-negative representatives of different microbial species, isolated from patients after primary hip replacement and osteosynthesis of long bones, which had post operative infectious complications, and also isolated from samples of traumatology department environment. Identification of sensitivity/resistance to antibiotics was performed with use of two methods - disc diffusion and serial dilution on solid nutrient media...
October 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27842800/anti-candida-albicans-natural-products-sources-of-new-antifungal-drugs-a-review
#15
REVIEW
A Zida, S Bamba, A Yacouba, R Ouedraogo-Traore, R T Guiguemdé
INTRODUCTION: Candida albicans is the most prevalent fungal pathogen in humans. Due to the development of drug resistance, there is today a need for new antifungal agents for the efficient management of C. albicans infections. Therefore, we reviewed antifungal activity, mechanisms of action, possible synergism with antifungal drugs of all natural substances experimented to be efficient against C. albicans for future. METHODS: An extensive and systematic review of the literature was undertaken and all relevant abstracts and full-text articles analyzed and included in the review...
November 11, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/27837519/molecular-detection-of-resistance-to-azole-components
#16
Brunella Posteraro, Antonietta Vella, Elena De Carolis, Maurizio Sanguinetti
Fungal infections have increased significantly in the last few years, and their outcomes are in part complicated by the emergence of antifungal drug-resistant pathogens. Together with Candida species, the mould Aspergillus fumigatus is one of the most prevalent organisms to cause invasive fungal disease. The molecular detection of (tri)azole resistance in both Candida and Aspergillus species may represent a useful means of monitoring the incidence of clinical isolates with antifungal resistance-associated gene alterations...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27837518/molecular-detection-of-resistance-to-echinocandins
#17
Brunella Posteraro, Antonietta Vella, Elena De Carolis, Maurizio Sanguinetti
In the last years, life-threatening fungal diseases have increased significantly, due to the rising number of human individuals susceptible to fungal infections, which are in part complicated by the emergence of antifungal drug-resistant pathogens. Among yeasts, Candida albicans and Candida glabrata are the most common organisms responsible for invasive fungal diseases. The molecular detection of echinocandin resistance in Candida species may represent a useful means of monitoring the incidence of clinical isolates with antifungal resistance-associated gene alterations...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27837497/the-changing-epidemiology-of-invasive-fungal-infections
#18
David A Enoch, Huina Yang, Sani H Aliyu, Christianne Micallef
Invasive fungal infections (IFI) are an emerging problem worldwide with invasive candidiasis and candidemia responsible for the majority of cases. This is predominantly driven by the widespread adoption of aggressive immunosuppressive therapy among certain patient populations (e.g., chemotherapy, transplants) and the increasing use of invasive devices such as central venous catheters (CVCs). The use of new immune modifying drugs has also opened up an entirely new spectrum of patients at risk of IFIs. While the epidemiology of candida infections has changed in the last decade, with a gradual shift from C...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27832049/investigation-of-the-first-seven-reported-cases-of-candida-auris-a-globally-emerging-invasive-multidrug-resistant-fungus-united-states-may-2013-august-2016
#19
Snigdha Vallabhaneni, Alex Kallen, Sharon Tsay, Nancy Chow, Rory Welsh, Janna Kerins, Sarah K Kemble, Massimo Pacilli, Stephanie R Black, Emily Landon, Jessica Ridgway, Tara N Palmore, Adrian Zelzany, Eleanor H Adams, Monica Quinn, Sudha Chaturvedi, Jane Greenko, Rafael Fernandez, Karen Southwick, E Yoko Furuya, David P Calfee, Camille Hamula, Gopi Patel, Patricia Barrett, Patricia Lafaro, Elizabeth L Berkow, Heather Moulton-Meissner, Judith Noble-Wang, Ryan P Fagan, Brendan R Jackson, Shawn R Lockhart, Anastasia P Litvintseva, Tom M Chiller
Candida auris, an emerging fungus that can cause invasive infections, is associated with high mortality and is often resistant to multiple antifungal drugs. C. auris was first described in 2009 after being isolated from external ear canal discharge of a patient in Japan (1). Since then, reports of C. auris infections, including bloodstream infections, have been published from several countries, including Colombia, India, Israel, Kenya, Kuwait, Pakistan, South Africa, South Korea, Venezuela, and the United Kingdom (2-7)...
November 11, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27824006/white-opaque-switching-in-different-mating-type-like-locus-gene-types-of-clinical-candida-albicans-isolates
#20
Hou-Min Li, Yumi Shimizu-Imanishi, Reiko Tanaka, Ruo-Yu Li, Takashi Yaguchi
BACKGROUND: Candida albicans (C. albicans) can become a pathogen causing superficial as well as life-threatening systemic infections, especially in immunocompromised patients. Many phenotypic attributes contribute to its capacity to colonize human organs. In our study, 93 C. albicans isolates from patients of various candidiasis in a hospital of China were surveyed. We aimed to investigate the white-opaque (WO) switching competence, drug sensitivity, and virulence of mating type-like (MTL) a/α isolates...
2016: Chinese Medical Journal
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