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Candida drug resistance

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https://www.readbyqxmd.com/read/29138481/quadoctomycin-a-48-membered-macrolide-antibiotic-from-streptomyces-sp-mm168-141f8
#1
Ryuichi Sawa, Yumiko Kubota, Maya Umekita, Masaki Hatano, Chigusa Hayashi, Masayuki Igarashi
Drug-resistant bacteria are still emerging, and screening of new skeletal antibiotics is important. During our continuous screening for antimicrobial agents, we discovered a new antimicrobial, named quadoctomycin, from solid culture of Streptomyces sp. MM168-141F8. The substance was purified by solvent extraction, silica gel chromatography and HPLC. Structural elucidation of quadoctomycin was performed by MS and NMR analyses and chemical degradation. Quadoctomycin possesses a 48-membered polyol macrolide skeleton in which an α-D-mannoside is connected to C-22 by an O-glycosidic linkage...
November 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/29133552/cd101-a-novel-echinocandin-possesses-potent-anti-biofilm-activity-against-early-and-mature-candida-albicans-biofilms
#2
Jyotsna Chandra, Mahmoud A Ghannoum
Currently available echinocandins are generally effective against Candida biofilms, but recent emergence of resistance has underscored the importance of developing new antifungal agents that are effective against biofilms. CD101 is a long-acting, novel echinocandin with distinctive pharmacokinetic properties and improved stability and safety relative to other drugs in the same class. CD101 is currently being evaluated as a once-weekly IV infusion for the treatment of candidemia and invasive candidiasis. In this study, we determined: (1) the effect of CD101 against early and mature phase biofilms formed by C...
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29132828/lactoferrin-chitosan-and-melaleuca-alternifolia-natural-products-that-show-promise-in-candidiasis-treatment
#3
REVIEW
Lorena de Oliveira Felipe, Willer Ferreira da Silva Júnior, Katialaine Corrêa de Araújo, Daniela Leite Fabrino
The evolution of microorganisms resistant to many medicines has become a major challenge for the scientific community around the world. Motivated by the gravity of such a situation, the World Health Organization released a report in 2014 with the aim of providing updated information on this critical scenario. Among the most worrying microorganisms, species from the genus Candida have exhibited a high rate of resistance to antifungal drugs. Therefore, the objective of this review is to show that the use of natural products (extracts or isolated biomolecules), along with conventional antifungal therapy, can be a very promising strategy to overcome microbial multiresistance...
November 10, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29127020/does-the-use-of-antifungal-agents-in-agriculture-and-in-food-foster-polyene-resistance-development-a-reason-for-concern
#4
REVIEW
Axel Dalhoff
Environmental fungicides are used in agriculture to reduce fungal spoilage of crop to a minimum and the polyene macrolide natamycin is used as a food preservative. The use of natamycin in yoghurt has recently been authorized in the USA and some other countries. However, resistance development is a serious risk associated with the use of antimicrobials as food additives and environmental fungicides. Cross-resistance between agricultural and medical azoles and amphothericin B, respectively, not being used in agriculture has been demonstrated in clinical and environmental isolates...
November 7, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29126739/discovery-of-simplified-sampangine-derivatives-as-novel-fungal-biofilm-inhibitors
#5
Na Liu, Hua Zhong, Jie Tu, Zhigan Jiang, Yanjuan Jiang, Yan Jiang, Yuanying Jiang, Jian Li, Wannian Zhang, Yan Wang, Chunquan Sheng
Lack of novel antifungal agents and severe drug resistance have led to high incidence and associated mortality of invasive fungal infections. To tackle the challenges, novel antifungal agents with new chemotype, fungicidal activity and anti-resistant potency are highly desirable. On the basis of our previously identified simplified analogue of antifungal natural product sampangine, systemic structure-activity relationships were clarified and two novel derivatives showed promising features as novel antifungal lead compounds...
October 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29123398/triclosan-resistance-reversion-by-encapsulation-in-chitosan-coated-nanocapsule-containing-%C3%AE-bisabolol-as-core-development-of-wound-dressing
#6
João Guilherme B De Marchi, Denise S Jornada, Fernanda K Silva, Ana L Freitas, Alexandre M Fuentefria, Adriana R Pohlmann, Silvia S Guterres
The use of nanoparticles may be particularly advantageous in treating bacterial infections due to their multiple simultaneous mechanisms of action. Nanoencapsulation is particularly useful for lipophilic drugs. In this scenario, triclosan is considered a good candidate due to its lipophilicity, broad-spectrum activity, and safety. In the present study, we have developed and characterized an antimicrobial suspension of triclosan and α-bisabolol against pathogenic strains that are resistant (Pseudomonas aeruginosa) and susceptible (Escherichia coli, Staphylococcus aureus, and Candida albicans) to triclosan...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29112170/psn-pc-a-novel-antimicrobial-and-anti-biofilm-peptide-from-the-skin-secretion-of-phyllomedusa-camba-with-cytotoxicity-on-human-lung-cancer-cell
#7
Xianhui Wu, Jinhuo Pan, Yue Wu, Xinping Xi, Chengbang Ma, Lei Wang, Mei Zhou, Tianbao Chen
Peptides derived from amphibian skin secretion are promising drug prototypes for combating widespread infection. In this study, a novel peptide belonging to the phylloseptin family of antimicrobial peptides was isolated from the skin secretion of the Phyllomedusa camba, namely phylloseptin-PC (PSN-PC). The biosynthetic precursor was obtained by molecular cloning and the mature peptide sequence was confirmed through tandem mass spectrometry (MS/MS) fragmentation sequencing in the skin secretion. The synthetic replicate exhibited a broad spectrum antimicrobial activity against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus,Escherichia coli, Pseudomonas aeruginosa, Candida albicans at concentrations of 2, 2, 8, 32 and 2 µM, respectively...
November 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29111434/empiric-treatment-of-lower-urinary-tract-infections-in-the-face-of-spreading-multi-drug-resistance-in-vitro-study-of-nitroxoline-effectiveness
#8
A Sobke, O Makarewicz, M Baier, C Bär, W Pfister, S G Gatermann, M W Pletz, C Forstner
The spread of antimicrobial resistance challenges the empiric treatment in urinary tract infections (UTI). Among others, nitrofurantoin is recommended for first line treatment, but acceptance among clinicians is limited due to chronic nitrofurantoin-induced lung toxicity and insufficient coverage of Enterobacteriaceae other than Escherichia coli. Nitroxoline seems to be an alternative to nitrofurantoin due to its favourable safety profile but data on its current in vitro susceptibility are sparse. In this study susceptibility to nitroxoline was tested against 3,012 urinary clinical isolates (including multidrug-resistant bacteria and Candida spp...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29111389/antifungal-photosensitive-activity-of-porophyllum-obscurum-spreng-dc-correlation-of-the-chemical-composition-of-the-hexane-extract-with-the-bioactivity
#9
Agustina Postigo, Matías Funes, Elisa Petenatti, Hebe Bottai, Adriana Pacciaroni, Maximiliano Sortino
In this paper, we report Porophyllum obscurum as a source of new photosensitizers with potential use in Photodynamic Therapy as an alternative for oropharyngeal candidiasis treatment. The antifungal photosensitive activity of different extracts from P. obscurum was evaluated by using microdilution and bioautographic assays. The Minimum Fungicidal Concentration for hexanic extract under UV-A irradiation was 0.98μg/mL, but it was inactive in experiments without irradiation. The bioassay-guided fractionation of this extract led to the isolation of four thiophenes responsible for the photosensitive activity: 2,2':5'2″terthiophene, 5-(3-buten-1-ynyl)-2,2'-bithiophene, 5-(4-acetoxy-1-butenyl)-2,2'- bithiophene and 5-(4-hydroxy-1-butenyl)-2,2'- bithiophene, with Minimum Fungicidal Concentrations ranging 0...
October 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29104260/antimicrobial-and-anti-proliferative-effects-of-skin-mucus-derived-from-dasyatis-pastinaca-linnaeus-1758
#10
Virginia Fuochi, Giovanni Li Volti, Giuseppina Camiolo, Francesco Tiralongo, Cesarina Giallongo, Alfio Distefano, Giulio Petronio Petronio, Ignazio Barbagallo, Maria Viola, Pio Maria Furneri, Michelino Di Rosa, Roberto Avola, Daniele Tibullo
Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferative effects of skin mucus derived from Dasyatis pastinaca (Linnaeus, 1758). Our results showed that skin mucus exhibited a significant and specific antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria...
November 1, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29101485/the-in-vitro-in-vivo-antifungal-activity-and-the-action-mode-of-jelleine-i-against-candida-species
#11
Fengjing Jia, Jiayi Wang, Jinxiu Peng, Ping Zhao, Ziqing Kong, Kairong Wang, Wenjin Yan, Rui Wang
Recently, the mortality of life-threatening fungal infections increased dramatically. However, there are few antifungals existed. Antimicrobial peptides (AMPs) as promising antifungal candidates have attracted much attention. Here, we present a small antimicrobial peptide Jelleine-I that had potent in vitro and in vivo antifungal activity. Negligible hemolytic activity and in vivo toxicity were observed. Selectivity index (SI) of Jelleine-I is at least 4.6 times higher than amphotericin B. Jelleine-I could increase the production of cellular ROS and bind with genome DNA...
November 3, 2017: Amino Acids
https://www.readbyqxmd.com/read/29101061/antimicrobial-efficacy-of-drug-blended-biosynthesized-colloidal-gold-nanoparticles-from-justicia-glauca-against-oral-pathogens-a-nanoantibiotic-approach
#12
Rayappan Emmanuel, Muthupandian Saravanan, Muhammad Ovais, Sethuramasamy Padmavathy, Zabta Khan Shinwari, Periyakaruppan Prakash
Antimicrobial resistance is a challenging task for researchers to develop new strategies. Green synthesis of AuNPs is an eco-friendly approach, which can be utilized in the microbistatic and microbicidal activities. The current study is focused on Justicia glauca (aqueous leaf extract) mediated AuNPs synthesis at room temperature by treating chloroaurate ions, that shows an antagonistic effect with Azithromycin (AZM) and Clarithromycin (CLR) antibiotics against oral pathogenic bacteria and fungi (Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus, Streptococcus mutans, Lactobacillus acidophilus, Escherichia coli, Pseudomonas aeruginosa, Saccharomyces cerevisiae and Candida albicans)...
October 31, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29094611/the-carboxylic-acid-transporters-jen1-and-jen2-affect-the-architecture-and-fluconazole-susceptibility-of-candida-albicans-biofilm-in-the-presence-of-lactate
#13
Rosana Alves, Sandra Mota, Sónia Silva, Célia F Rodrigues, Alistair J P Brown, Mariana Henriques, Margarida Casal, Sandra Paiva
Candida albicans has the ability to adapt to different host niches, often glucose-limited but rich in alternative carbon sources. In these glucose-poor microenvironments, this pathogen expresses JEN1 and JEN2 genes, encoding carboxylate transporters, which are important in the early stages of infection. This work investigated how host microenvironments, in particular acidic containing lactic acid, affect C. albicans biofilm formation and antifungal drug resistance. Multiple components of the extracellular matrix were also analysed, including their impact on antifungal drug resistance, and the involvement of both Jen1 and Jen2 in this process...
November 2, 2017: Biofouling
https://www.readbyqxmd.com/read/29091404/incorporation-of-%C3%AE-peptides-enhances-the-antifungal-activity-and-selectivity-of-the-helical-antimicrobial-peptide-aurein-1-2
#14
Myung-Ryul Lee, Namrata Raman, Samuel H Gellman, David M Lynn, Sean P Palecek
Antimicrobial peptides (AMPs) are attractive antifungal drug candidates because they kill microbes via membrane disruption and are thus less likely to provoke development of resistance. Low selectivity for fungal vs. human cells and instability in physiological environments have limited the development of AMPs as therapeutics, but peptidomimetic AMPs can overcome these obstacles and also provide useful insight into AMP structure-function relationships. Here, we describe antifungal peptidomimetic α/β-peptides templated on the natural α-peptidic AMP aurein 1...
November 1, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29080032/anticandidal-activity-of-hetero-dinuclear-copper-ii-mn-ii-schiff-base-and-its-potential-action-of-the-mechanism
#15
Bekir Mustafa Yoğurtçu, Selami Demirci, Ayşegül Doğan, Ayla Burçin Asutay, Fikrettin Şahin
Invasive fungal infections are one of the major challenges especially for immunosuppressed patients since they are drug resistant and pathogen to patients. Therefore, developing new, efficient and nonresistant antifungal agents have been a primary focus of international research. In the current study, a novel Schiff base [hetero-dinuclear copper(II) Mn(II) complex] (SB) derivative was investigated for its anticandidal activity against Candida albicans and possible mechanisms inducing cell death. The results revealed that SB treatment induces apoptotic and necrotic pathways in C...
October 27, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29076804/chain-length-specific-anti-candida-activity-of-cationic-lipo-oxazoles-a-new-class-of-quaternary-ammonium-compounds
#16
Tushar Jain, Pratap Reddy Muktapuram, Satyanarayana Pochampalli, Komal Sharma, Garima Pant, Kalyan Mitra, Surendar Reddy Bathula, Dibyendu Banerjee
PURPOSE: Candida species have become resistant to commonly used anti-fungal drugs like fluconazole and echinocandins. In our screen, a series of quaternary ammonium compounds (QACs) emerged as an alternative treatment choice for drug-resistant Candida infections. METHODOLOGY: Medium alkyl chain cationic lipo-oxazoles comprising six to thirteen twin carbon chains and a quaternary ammonium unit were synthesized and evaluated for their in vitro anti-Candida and biofilm inhibition activity...
October 27, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29074435/the-natural-compound-magnolol-affects-growth-biofilm-formation-and-ultrastructure-of-oral-candida-isolates
#17
Jawad Behbehani, Sheikh Shreaz, Mohammad Irshad, Maribassapa Karched
The incidence of oral candidosis has increased in recent years due to the escalation in HIV-infection, cancer treatments, organ transplantation, and diabetes. In addition, corticosteroid use, dentures, and broad-spectrum antibiotic use have also contributed to the problem. Treatment of oral candidosis has continued to be problematic because of the potential toxicity of antifungals in clinical use, and, above all, development of drug resistance among patients. In this study, the antifungal effect of magnolol was investigated against 64 strains of Candida spp...
October 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29062309/ph-dependant-antifungal-activity-of-valproic-acid-against-the-human-fungal-pathogen-candida-albicans
#18
Julien Chaillot, Faiza Tebbji, Carlos García, Hugo Wurtele, René Pelletier, Adnane Sellam
Current antifungal drugs suffer from limitations including toxicity, the emergence of resistance and decreased efficacy at low pH that are typical of human vaginal surfaces. Here, we have shown that the antipsychotic drug valproic acid (VPA) exhibited a strong antifungal activity against both sensitive and resistant Candida albicans in pH condition similar to that encountered in vagina. VPA exerted a strong anti-biofilm activity and attenuated damage of vaginal epithelial cells caused by C. albicans. We also showed that VPA synergizes with the allylamine antifungal, Terbinafine...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29062048/nacre-mimic-reinforced-ag-reduced-graphene-oxide-sodium-alginate-composite-film-for-wound-healing
#19
Xu Yan, Fei Li, Kang-Di Hu, Jingzhe Xue, Xiao-Feng Pan, Tao He, Liang Dong, Xiang-Ying Wang, Ya-Dong Wu, Yong-Hong Song, Wei-Ping Xu, Yang Lu
With the emerging of drug-resistant bacterial and fungal pathogens, there raise the interest of utilizing versatile antimicrobial biomaterials to treat the acute wound. Herein, we report the spraying mediated assembly of a bio-inspired Ag@reduced graphene-sodium alginate (AGSA) composite film for effective wound healing. The obtained film displayed lamellar microstructures similar to the typical "brick-and-mortar" structure in nacre. In this nacre-mimic structure, there are abundant interfacial interactions between nanosheets and polymeric matrix, leading to remarkable reinforcement...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051092/a-study-on-the-targeted-surveillance-of-nosocomial-infection-in-intensive-care-units-of-177-hospitals-in-jiangsu-province-of-china
#20
Yang Li, Xiao-Li Cao, Hai Ge, Yi-Hong Jiang, Hong Zhou, Wei Zheng
BACKGROUND: Nosocomial infections (NIs) impact care and costs in hospitals across the globe. There are minimal data on targeted surveillance of NI in intensive care units (ICUs), and data specific to the risk factors for NI are especially limited. METHODS: One hundred seventy-seven secondary and tertiary hospitals performed NI targeted surveillance in their ICUs. The data were collected and summarized by Minke software, then fed back once per quarter. RESULTS: The incidence of NI appeared to decrease, and the incidence of NI per 1000 patient-days and adjusted incidence were 25...
October 16, 2017: Journal of Hospital Infection
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