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Radioembolization

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https://www.readbyqxmd.com/read/29116741/high-performance-plga-magnetic-microspheres-prepared-by-rotating-membrane-emulsification-for-transcatheter-arterial-embolization-and-magnetic-ablation-in-vx2-liver-tumors
#1
Yi-Jun Liang, Hui Yu, Guodong Feng, Linlin Zhuang, Wei Xi, Ming Ma, Jun Chen, Ning Gu, Yu Zhang
Interventional embolization is a popular minimally invasive vascular therapeutic technique and has been widely applied for hepatocellular carcinoma (HCC) therapy. However, harmful effects caused by transcatheter arterial chemoembolization (TACE) and radioembolization, such as the toxicity of chemotherapy or excessive radiation damage, are serious disadvantages and significantly reduce the therapeutic efficacy. Here, a synergistic therapeutic strategy combined transcatheter arterial embolization and magnetic ablation (TAEMA) by using PLGA-magnetic microspheres (MMs) has been successfully applied to orthotopic VX2 liver tumors of rabbits...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29108656/hepatocellular-carcinoma-treatment-ablation-and-arterial-embolization
#2
J I Bilbao, M Páramo, J M Madrid, A Benito
Percutaneous and endovascular techniques take an important role in the therapeutic management of patients with hepatocarcinoma. Different techniques of percutaneous ablation, especially indicated in tumors up to 2cm diameter offer, at least, similar results to surgical resection. Taking advantage of double hepatic vascularization and exclusive tumor nutrition by the artery, several endovascular techniques of treating the tumor have been developed. Intra-arterial administration of embolizing particles, alone or charged with drug (chemoembolization), will produce ischemia and consequent necrosis with excellent results in selected patients...
November 3, 2017: Radiología
https://www.readbyqxmd.com/read/29090997/safety-and-efficacy-outcomes-of-embolization-in-hepatic-sarcomas
#3
David B Pierce, Guy E Johnson, Eric Monroe, Elizabeth T Loggers, Robin L Jones, Seth M Pollack, Siddharth A Padia
OBJECTIVE: The outcome for patients with unresectable hepatic sarcoma is poor with a median survival period of 12-16 months. The purpose of this study was to evaluate liver-directed transcatheter therapies for the treatment of hepatic sarcomas. MATERIALS AND METHODS: In a retrospective study, the cases of patients with primary and metastatic hepatic sarcoma treated by transcatheter embolization, chemoembolization, and (90)Y radioembolization between 2004 and 2015 were identified...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29080006/local-arterial-therapies-in-the-management-of-unresectable-hepatocellular-carcinoma
#4
REVIEW
Samdeep K Mouli, Laura W Goff
Most patients with hepatocellular carcinoma present with intermediate to advanced disease, where curative therapies are no longer an option. These patients with intermediate to advanced disease represent a heterogeneous population with regard to tumor burden, liver function, and performance status. While the Barcelona Clinic Liver Cancer (BCLC) staging system offers guidelines for the management of these patients, strict adherence to these guidelines may limit treatment options for these patients. Several locoregional therapies exist for these patients, including conventional transarterial chemoembolization (cTACE), transarterial embolization (TAE), drug-eluting embolization (DEE), and radioembolization...
October 27, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29074347/management-consensus-guideline-for-hepatocellular-carcinoma-2016-updated-by-the-taiwan-liver-cancer-association-and-the-gastroenterological-society-of-taiwan
#5
(no author information available yet)
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality in Taiwan. To help clinical physicians to manage patients with HCC, the Taiwan Liver Cancer Association and the Gastroenterological Society of Taiwan produced the management consensus guideline for HCC. METHODS: The recommendations focus on nine important issues on management of HCC, including surveillance, diagnosis, staging, surgery, local ablation, transarterial chemoembolization/transarterial radioembolization/hepatic arterial infusion chemotherapy, systemic therapy, radiotherapy, and prevention...
October 23, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29072955/imaging-of-hepatocellular-carcinoma-response-after-90-y-radioembolization
#6
REVIEW
Sahar Semaan, Jasnit Makkar, Sara Lewis, Manjil Chatterji, Edward Kim, Bachir Taouli
OBJECTIVE: The purpose of this study is to discuss the imaging modalities and response criteria used for assessing hepatocellular carcinoma (HCC) response to (90)Y radioembolization, as well as the imaging appearances of treated tumors. CONCLUSION: An understanding of the appearance of HCC after (90)Y radioembolization is crucial for accurate evaluation of treatment response. Residual tumor necrosis and enhancement are essential for assessing response. Multiparametric MRI, including DWI and perfusion imaging, plays an emerging role in response assessment and outcome prediction...
November 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29067511/safety-and-efficacy-of-transarterial-radioembolization-combined-with-chemoembolization-for-bilobar-hepatocellular-carcinoma-a-single-center-retrospective-study
#7
Joon Ho Kwon, Gyoung Min Kim, Kichang Han, Jong Yun Won, Man Deuk Kim, Do Yun Lee, Junhyung Lee, Woosun Choi, Yong Seek Kim, Do Young Kim, Kwang-Hyub Han
BACKGROUND: Radioembolization induced liver disease (REILD) is a possible sequela of transarterial radioembolization (TARE), particularly in cases of whole-liver treatment. To mitigate this problem, the safety and efficacy of combined transarterial chemoembolization (TACE) and TARE were evaluated for patients with bilobar hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Nineteen patients (mean age 60 years; range 27-82 years) treated for HCC between June 2012 and September 2014 were included in the analysis...
October 24, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29063296/surgical-resection-does-not-improve-survival-in-multifocal-intrahepatic-cholangiocarcinoma-a-comparison-of-surgical-resection-with-intra-arterial-therapies
#8
G Paul Wright, Samantha Perkins, Heather Jones, Amer H Zureikat, J Wallis Marsh, Matthew P Holtzman, Herbert J Zeh, David L Bartlett, James F Pingpank
BACKGROUND: Multifocal intrahepatic cholangiocarcinoma (ICC) has traditionally been treated with surgical resection when amenable. Intra-arterial therapy (IAT) for multifocal ICC has not been directly compared with surgical resection. METHODS: A single-center, retrospective review of consecutive patients treated for multifocal ICC was conducted. Patients with distant metastases or treatment with systemic chemotherapy alone were excluded. Patients were divided into two groups: surgical resection versus IAT; IAT included transarterial chemoembolization (TACE), transarterial radioembolization (TARE), and hepatic arterial infusion (HAI) pump therapy...
October 23, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29057748/dosimetry-and-prescription-in-liver-radioembolization-with-90y-microspheres-3d-calculation-of-tumor-to-liver-ratio-from-global-99mtc-maa-spect-information
#9
Fernando Mañeru, Dolores Abós, Laura Bragado, Naiara Fuentemilla, Fernando Caudepón, Santiago Pellejero, Santiago Miquelez, Anastasio Rubio, Elena Goñi, Araceli Hernández-Vitoria
Dosimetry in liver radioembolization with <sup>90</sup>Y microspheres is a fundamental tool, both for the optimization of each treatment and for improving knowledge of the treatment effects in the tissues. Different options are available for estimating the administered activity and the tumor/organ dose, among them the so-called partition method. The key factor in the partition method is the tumor/normal tissue activity uptake ratio (T/N), which is obtained by a Single-Photon Emission Computed Tomography (SPECT) scan during a pre-treatment simulation...
October 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29056190/positron-emission-tomography-ct-to-localize-radioactivity-in-a-radioembolization-delivery-system
#10
Robert Drescher, Philipp Seifert, René Aschenbach, Martin Freesmeyer
No abstract text is available yet for this article.
November 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29052747/angiosomal-radiopathologic-analysis-of-transarterial-radioembolization%C3%A2-for-the-treatment-of-hepatocellular-carcinoma
#11
Altan F Ahmed, Naziya Samreen, Joseph R Grajo, Ivan Zendejas, Chris L Sistrom, Amy Collinsworth, Ashwini Esnakula, Jehan L Shah, Roniel Cabrera, Brian S Geller, Beau B Toskich
PURPOSE: To assess the radiopathologic correlation following Yttrium-90 transarterial radioembolization (TARE) of hepatocellular carcinoma (HCC) using variable radiodosimetry to identify imaging surrogates of histologic response. METHODS: Twelve patients with HCC underwent ablative (≥ 190 Gy) and/or non-ablative (< 190 Gy) TARE delivered in a segmental, lobar, or combined fashion as a surgical neoadjuvant or bridge to transplantation. Both targeted tumor and treatment angiosome were analyzed before and after TARE utilizing hepatocyte-specific contrast-enhanced MRI or contrast-enhanced CT...
October 20, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29049048/urinary-excretion-of-yttrium-90-after-radioembolization-with-yttrium-90-labeled-resin-based-microspheres
#12
Oliver S Grosser, Juri Ruf, Annette Pethe, Dennis Kupitz, Heiko Wissel, Christoph Benckert, Maciej Pech, Jens Ricke, Holger Amthauer
In radioembolic therapy (RET) of hepatic malignancies using yttrium-90 (Y)-labeled resin microspheres, radiation protection is primarily concerned with avoiding contamination by radioactive spheres. However, as Y is bound to the microsphere surface by a potentially reversible ion-exchange process, the aim of this study was to assess the extent of the potential excreted activity in urine. After RET with Y-labeled resin-based microspheres, urinary excretion of free Y was prospectively analyzed in 51 interventions (n = 45 patients) by sampling urine over 48 h (two 24-h intervals) consecutively...
October 18, 2017: Health Physics
https://www.readbyqxmd.com/read/29045224/is-segmentectomy-a-suitable-term-to-use-in-patients-undergoing-hepatic-segmental-90-y-radioembolization-for-the-treatment-of-hepatocellular-carcinoma-up-to-3-cm
#13
Olivier Seror, Jean-Charles Nault, Gisele N'Kontchou, Olivier Sutter, Pierre Nahon
No abstract text is available yet for this article.
November 2017: Radiology
https://www.readbyqxmd.com/read/29036038/the-evolving-role-of-radioembolization-in-hepatocellular-carcinoma
#14
Matthew S Johnson
No abstract text is available yet for this article.
August 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29036035/the-treatment-path-in-hepatocellular-carcinoma
#15
Hashem B El-Serag, Andrew X Zhu, Matthew S Johnson
The treatment approach for hepatocellular carcinoma (HCC) depends on the stage and extent of disease, the severity of the underlying liver disease, and the overall performance status of the patient. Treatment consists of 4 main strategies: surgery (eg, resection and liver transplant), locoregional procedures (eg, ablation and transarterial embolization), systemic therapies, and best supportive care. For patients with early-stage tumors, surgical treatment or ablation can be curative. Patients with intermediate-stage disease can be candidates for embolization, administered as either transarterial chemoembolization (TACE) or transarterial radioembolization (TARE)...
August 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29033589/yttrium-90-radioembolization-of-unresectable-hepatocellular-carcinoma-a-single-center-experience
#16
Carsten Meyer, Claus Christian Pieper, Hojjat Ahmadzadehfar, Nina Alexandra Lampe, Eva Maria E Matuschek, Thomas Adrian Maschke, Simon Jonas Enkirch, Markus Essler, Ulrich Spengler, Hans Heinz Schild
PURPOSE: To determine the value of radioembolization (RE) for treatment of unresectable hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Records of patients undergoing RE for unresectable HCC were retrospectively reviewed. Biochemical and clinical toxicities, imaging response (according to modified Response Evaluation Criteria In Solid Tumors), time-to-progression (TTP) and overall survival (OS) were analyzed. Data were stratified according to clinical and procedural parameters...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29028102/the-ten-commandments-of-hepatic-radioembolization-expert-discussion-and-report-from-mediterranean-interventional-oncology-miolive-congress-2017
#17
J L Bilbao, R Iezzi, S N Goldberg, A Sami, O Akhan, F Giuliante, M Pompili, L Crocetti, K Malagari, V Valentini, A Gasbarrini, C Colosimo, R Manfredi
Microsphere and particle technology represent the next-generation agents that have formed the basis of interventional oncology, an evolving subspecialty of interventional radiology. One of these platforms, yttrium-90 microspheres, is increasingly being used as a treatment modality for primary and secondary liver tumors. Due to the widespread use of radioembolization, a comprehensive review of the methodologic and technical considerations seems to be mandatory. This article summarizes the expert discussion and report from Mediterranean Interventional Oncology Live Congress (MIOLive 2017) that was held in Rome, Italy, integrating evidence-reported literature and experience-based perceptions, to assist not only residents and fellows who are training in interventional radiologists but also practicing colleagues who are approaching to this intra-arterial treatment...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29023925/radioembolization-for-hepatocellular-carcinoma-the-time-has-come
#18
EDITORIAL
Beau Toskich, Tushar Patel
No abstract text is available yet for this article.
October 12, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28955121/erratum-hepatic-radioembolization-complicated-by-abscess
#19
Neil Mascarenhas, Robert K Ryu, Riad Salem
[This corrects the article DOI: 10.1055/s-0031-1280669.].
September 2017: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/28940483/improved-quantitative-90-y-bremsstrahlung-spect-ct-reconstruction-with-monte-carlo-scatter-modeling
#20
Yuni K Dewaraja, Se Young Chun, Ravi N Srinivasa, Ravi K Kaza, Kyle C Cuneo, Bill S Majdalany, Paula M Novelli, Michael Ljungberg, Jeffrey A Fessler
PURPOSE: In (90) Y microsphere radioembolization (RE), accurate post-therapy imaging-based dosimetry is important for establishing absorbed dose versus outcome relationships for developing future treatment planning strategies. Additionally, accurately assessing microsphere distributions is important because of concerns for unexpected activity deposition outside the liver. Quantitative (90) Y imaging by either SPECT or PET is challenging. In (90) Y SPECT model based methods are necessary for scatter correction because energy window-based methods are not feasible with the continuous bremsstrahlung energy spectrum...
September 22, 2017: Medical Physics
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