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https://www.readbyqxmd.com/read/28229076/locoregional-therapies-of-cholangiocarcinoma
#1
REVIEW
Christof M Sommer, Hans U Kauczor, Philippe L Pereira
BACKGROUND: Cholangiocarcinoma (CC) is the second most primary liver malignancy with increasing incidence in Western countries. Currently, surgical R0 resection is regarded as the only potentially curative treatment. The results of systemic chemotherapy and best supportive care (BSC) in patients with metastatic disease are often disappointing in regard to toxicity, oncologic efficacy, and overall survival. In current practice, the use of different locoregional therapies is increasingly more accepted...
December 2016: Visceral Medicine
https://www.readbyqxmd.com/read/28206962/pi3k-pathway-mutations-are-associated-with-longer-time-to-local-progression-after-radioembolization-of-colorectal-liver-metastases
#2
Etay Ziv, Michael Bergen, Hooman Yarmohammadi, F Ed Boas, E Nadia Petre, Constantinos T Sofocleous, Rona Yaeger, David B Solit, Stephen B Solomon, Joseph P Erinjeri
PURPOSE: To establish the relationship between common mutations in the MAPK and PI3K signaling pathways and local progression after radioembolization. MATERIALS AND METHODS: Retrospective review of a HIPAA-compliant institutional review-board approved database identified 40 patients with chemo-refractory colorectal liver metastases treated with radioembolization who underwent tumor genotyping for hotspot mutations in 6 key genes in the MAPK/PI3K pathways (KRAS, NRAS, BRAF, MEK1, PIK3CA, and AKT1)...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28197686/pre-therapeutic-factors-for-predicting-survival-after-radioembolization-a-single-center-experience-in-389-patients
#3
K J Paprottka, F Schoeppe, M Ingrisch, J Rübenthaler, N N Sommer, E De Toni, H Ilhan, M Zacherl, A Todica, P M Paprottka
PURPOSE: To determine pre-therapeutic predictive factors for overall survival (OS) after yttrium (Y)-90 radioembolization (RE). METHODS: We retrospectively analyzed the pre-therapeutic characteristics (sex, age, tumor entity, hepatic tumor burden, extrahepatic disease [EHD] and liver function [with focus on bilirubin and cholinesterase level]) of 389 consecutive patients with various refractory liver-dominant tumors (hepatocellular carcinoma [HCC], cholangiocarcinoma [CCC], neuroendocrine tumor [NET], colorectal cancer [CRC] and metastatic breast cancer [MBC]), who received Y-90 radioembolization for predicting survival...
February 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28196771/liver-metastases-from-breast-cancer-what-role-for-surgery-indications-and-results
#4
REVIEW
Nicolas Golse, René Adam
Liver metastases from breast cancer (LMBC) have long been considered as a systemic disease because of the hematological route of dissemination, requiring noncurative management. In fact, despite recent advances in drug therapies personalized to tumor phenotype, the chances of a cure are nil and there is little hope of long-term survivors after nonsurgical management alone. By contrast, there is a growing evidence in the literature for satisfactory long-term results after a combination of chemotherapy and liver resection, with 5-year survival reaching >40% in some series...
January 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28190710/neutrophil-to-lymphocyte-ratio-predicts-disease-progression-following-intra-arterial-therapy-of-hepatocellular-carcinoma
#5
Matthew D Taussig, Mary Ellen Irene Koran, Samdeep K Mouli, Asma Ahmad, Sunil Geevarghese, Jennifer C Baker, Andrew J Lipnik, Fil Banovac, Daniel B Brown
BACKGROUND: Prospectively predicting response to intra-arterial therapy for hepatocellular carcinoma (HCC) is challenging. Neutrophil/lymphocyte ratio (NLR) is a serum biomarker that is associated with survival for multiple malignancies. It was hypothesized that increased NLR would be associated with early disease progression after intra-arterial therapy of HCC. METHODS: The outcomes of 86 treatment-naïve patients who had chemoembolization or radioembolization of HCC between July 2013-July 2014 were reviewed...
February 9, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28179284/the-evolving-role-of-local-treatments-for-hcc-in-the-third-millennium
#6
REVIEW
Paolo Magistri, Giuseppe Tarantino, Roberto Ballarin, Massimiliano Berretta, Annarita Pecchi, Giovanni Ramacciato, Fabrizio DI Benedetto
BACKGROUND: Hepatocellular carcinoma (HCC) represents the fifth most common malignancy and the third cancer-related cause of death worldwide. The aim of this review was to clarify the role of local treatments for HCC, analyzing the indications and defining future perspectives. MATERIALS AND METHODS: A systematic literature search was performed independently by two of the authors according to the PRISMA statement guidelines. The search was limited to studies reported in English between January 2005 and June 2016...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28154910/value-of-tumor-stiffness-measured-with-mr-elastography-for-assessment-of-response-of-hepatocellular-carcinoma-to-locoregional-therapy
#7
Sonja Gordic, Jad Bou Ayache, Paul Kennedy, Cecilia Besa, Mathilde Wagner, Octavia Bane, Richard L Ehman, Edward Kim, Bachir Taouli
PURPOSE: The aim of the study was to correlate tumor stiffness (TS) measured with MR elastography (MRE) with degree of tumor enhancement and necrosis on contrast-enhanced T1-weighted imaging (CE-T1WI) in hepatocellular carcinomas (HCC) treated with Yttrium-90 radioembolization (RE) or transarterial chemoembolization plus radiofrequency ablation (TACE/RFA). MATERIAL AND METHODS: This retrospective study was IRB-approved and the requirement for informed consent was waived...
February 2, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28154776/portal-vein-tumor-thrombus-is-a-bottleneck-in-the-treatment-of-hepatocellular-carcinoma
#8
Ju-Xian Sun, Jie Shi, Nan Li, Wei-Xing Guo, Meng-Chao Wu, Wan-Yee Lau, Shu-Qun Cheng
The effect of portal vein tumor thrombus (PVTT) on the prognosis of patients with hepatocellular carcinoma has become clear over the past several decades. However, identifying the mechanisms and performing the diagnosis and treatment of PVTT remain challenging. Therefore, this study aimed to summarize the progress in these areas. A computerized literature search in Medline and EMBASE was performed with the following combinations of search terms: "hepatocellular carcinoma" AND "portal vein tumor thrombus." Although several signal transduction or molecular pathways related to PVTT have been identified, the exact mechanisms of PVTT are still largely unknown...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28132407/single-institution-experience-of-radioembolization-with-yttrium-90-microspheres-for-unresectable-metastatic-neuroendocrine-liver-tumors
#9
Zhongzhi Jia, Ricardo Paz-Fumagalli, Gregory Frey, David M Sella, J Mark McKinney, Weiping Wang
PURPOSE: To assess the effectiveness of yttrium-90 ((90) Y) microspheres for the treatment of unresectable metastatic liver neuroendocrine tumors (NET). METHODS: From February 2006 to September 2015, 36 patients (19 male and 17 female, age, 63.6 ± 9.4 years) who underwent (90) Y therapy for unresectable liver metastases of NET were included and analyzed retrospectively. All patients received a variety of treatments prior to (90) Y therapy. The radiological response, symptoms improvement of carcinoid syndrome, tumor marker changes, complications, side effects/toxicity, survival and factors related to survival were evaluated and analyzed...
January 29, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28130578/-liver-metastases-of-colorectal-cancer
#10
R-T Hoffmann
Liver metastases are the most common cause of death in colorectal cancer patients. Nowadays, complete resection is considered to be the only curative treatment but only approximately 25% of patients are suitable candidates for surgery; therefore, many different interventional oncology techniques have been developed in recent years for the treatment of secondary liver metastases. The aim of interventional oncological procedures is either to provide a potentially curative treatment option for locally limited metastases with local ablative techniques, to enable nonresectable tumors to become accessible to surgical or local ablative techniques using transarterial procedures or to achieve improved survival in a palliative setting...
February 2017: Der Radiologe
https://www.readbyqxmd.com/read/28121731/differences-in-radiation-activity-between-glass-and-resin-90y-microspheres-in-treating-unresectable-hepatic-cancer
#11
Trent James, Jacqueline Hill, Thomas Fahrbach, Zachary Collins
The purpose of this study was to compare the difference in prescribed radiation activity between glass and resin yttrium-90 (Y) microspheres for radioembolization of unresectable hepatocellular carcinoma (HCC) or liver metastases at a tertiary care teaching institution. The authors performed a retrospective analysis on 126 patients with primary HCC and hepatic metastatic disease from extrahepatic primary cancers who underwent radioembolization with glass or resin particles between 2008 and 2013 at their institution...
March 2017: Health Physics
https://www.readbyqxmd.com/read/28099100/lung-shunting-an-indicator-of-survival-but-not-necessarily-a-tool-for-selecting-patients-for-radioembolization
#12
Maarten L J Smits, Remco Bastiaannet, Jip F Prince, Hugo W A M de Jong, Maurice A A J van den Bosch, Marnix G E H Lam
No abstract text is available yet for this article.
February 2017: Radiology
https://www.readbyqxmd.com/read/28078375/assessing-intra-arterial-complications-of-planning-and-treatment-angiograms-for-y-90-radioembolization
#13
Osman Ahmed, Mikin V Patel, Abdulrahman Masrani, Bradford Chong, Mohammed Osman, Jordan Tasse, Jayesh Soni, Ulku Cenk Turba, Bulent Arslan
PURPOSE: To report hepatic arterial-related complications encountered during planning and treatment angiograms for radioembolization and understand any potential-associated risk factors. MATERIALS AND METHODS: 518 mapping or treatment angiograms for 180 patients with primary or metastatic disease to the liver treated by Yttrium-90 radioembolization between 2/2010 and 12/2015 were retrospectively reviewed. Intra-procedural complications were recorded per SIR guidelines...
January 11, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28078110/radioembolization-with-90-y-glass-microspheres-for-the-treatment-of-unresectable-metastatic-liver-disease-from-chemotherapy-refractory-gastrointestinal-cancers-final-report-of-a-prospective-pilot-study
#14
Nicholas Fidelman, Robert K Kerlan, Randall A Hawkins, Miguel Pampaloni, Andrew G Taylor, Maureen P Kohi, K Pallav Kolli, Chloe E Atreya, Emily K Bergsland, R Kate Kelley, Andrew H Ko, W Michael Korn, Katherine Van Loon, Ryan M McWhirter, Jennifer Luan, Curt Johanson, Alan P Venook
BACKGROUND: This prospective pilot single-institution study was undertaken to document the feasibility, safety, and efficacy of radioembolization of liver-dominant metastatic gastrointestinal cancer using (90)Y glass microspheres. METHODS: Between June 2010 and October 2013, 42 adult patients (26 men, 16 women; median age 60 years) with metastatic chemotherapy-refractory unresectable colorectal (n=21), neuroendocrine (n=11), intrahepatic bile duct (n=7), pancreas (n=2), and esophageal (n=1) carcinomas underwent 60 lobar or segmental administrations of (90)Y glass microspheres...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28072623/effect-of-substituting-50-isovue-for-sterile-water-as-the-delivery-medium-for-sir-spheres-improved-dose-delivery-and-decreased-incidence-of-stasis
#15
Cherng Chao, S William Stavropoulos, Jeffrey I Mondschein, Mandeep Dagli, Deepak Sudheendra, Gregory Nadolski, Michael C Soulen
PURPOSE: The objective of this study was to evaluate the effect of substituting 50% Isovue (Bracco Diagnostics Inc, Monroe Township, NJ) for sterile water on the delivery of Y resin microspheres (SIR-Spheres [Sirtex Medical Limited, Sydney, Australia]). MATERIALS AND METHODS: The authors retrospectively reviewed all SIR-Spheres radioembolizations at the authors' institution from January 1, 2011, to February 10, 2014. From January 1, 2011, to April 30, 2013, all users performed SIR-Spheres radioembolization per the manufacturer's original instructions using sterile water in the B and D lines and intermittently checking the progress of the embolization by injecting contrast via the B line...
March 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28058660/hepatobiliary-scintigraphy-may-improve-radioembolization-treatment-planning-in-hcc-patients
#16
Manon N G J A Braat, Hugo W de Jong, Beatrijs A Seinstra, Mike V Scholten, Maurice A A J van den Bosch, Marnix G E H Lam
BACKGROUND: Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improve patient selection and treatment planning. A case series will be presented to illustrate the potential of this technique. Hepatocellular carcinoma patients with cirrhosis (Child-Pugh A and B) underwent hepatobiliary scintigraphy pre- and 3 months post-radioembolization as part of a prospective study protocol, which was prematurely terminated because of limited accrual...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28058021/prognostic-value-of-pre-treatment-f-18-fdg-pet-ct-in-patients-with-hepatocellular-carcinoma-undergoing-radioembolization
#17
Yazan Abuodeh, Arash O Naghavi, Kamran A Ahmed, Puja S Venkat, Youngchul Kim, Bela Kis, Junsung Choi, Benjamin Biebel, Jennifer Sweeney, Daniel A Anaya, Richard Kim, Mokenge Malafa, Jessica M Frakes, Sarah E Hoffe, Ghassan El-Haddad
AIM: To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization. METHODS: We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients were seen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control (LLC), distant liver control (DLC), time to distant metastases (DM), progression free survival (PFS) and overall survival (OS)...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28047827/su-c-204-01-a-dosimetric-investigation-into-the-effects-of-yttrium-90-radioembolization-on-the-gi-tract-in-vivo-and-histological-analysis-in-an-animal-model
#18
A Pasciak, L Nodit, A Bourgeois, B Paxton, A Arepally, Y Bradley
PURPOSE: In Yttrium-90 (90Y) radioembolization, non-target embolization (NTE) to the stomach or small bowel can result in ulceration, a rare but difficult to manage clinical complication. However, dosimetric thresholds for toxicity to these tissues from radioembolization have never been evaluated in a controlled setting. We performed an analysis of the effect of 90Y radioembolization in a porcine model at different absorbed-dose endpoints. METHODS: Under approval of the University of Tennessee IACUC, 6 female pigs were included in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047017/su-c-204-07-radiation-therapy-as-a-potential-treatment-for-obesity-initial-data-from-a-preclinical-investigation
#19
A Pasciak, Y Bradley, L Nodit, A Bourgeois, B Paxton, A Arepally
PURPOSE: To evaluate the feasibility of Yttrium-90 (90Y) radionuclide therapy as a potential treatment for obesity in a porcine model. As the only appetite-stimulating hormone, localized targeting of ghrelin-producing X/A cells in the fundus of the stomach using 90Y may reduce serum ghrelin levels and decrease hunger. METHODS: Under approval of the University of Tennessee IACUC, 8 young female pigs aged 12-13 weeks and weighing 21.8-28.1 Kg were included in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046903/su-f-t-687-comparison-of-spect-ct-based-methodologies-for-estimating-lung-dose-from-y-90-radioembolization
#20
S Kost, S Lin, N Yu
PURPOSE: To compare mean lung dose (MLD) estimates from 99mTc macroaggregated albumin (MAA) SPECT/CT using two published methodologies for patients treated with (90) Y radioembolization for liver cancer. METHODS: MLD was estimated retrospectively using two methodologies for 40 patients from SPECT/CT images of 99mTc-MAA administered prior to radioembolization. In these two methods, lung shunt fractions (LSFs) were calculated as the ratio of scanned lung activity to the activity in the entire scan volume or to the sum of activity in the lung and liver respectively...
June 2016: Medical Physics
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