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https://www.readbyqxmd.com/read/28435148/plasma-mediated-protein-immobilisation-enhances-the-vascular-compatibility-of-polyurethane-with-tissue-matched-mechanical-properties
#1
Irina Kondyurina, Steven Wise, Alan Ngo, Elysse Filipe, Alexey Kondyurin, Anthony Weiss, Shisan Bao, Marcela Bilek
Polyurethanes are a diverse class of polymers, with independently tunable mechanical and biodegradation properties making them a versatile platform material for biomedical implants. Previous iterations have failed to adequately embody appropriate mechanical and biological properties, particularly for vascular medicine where strength, compliance and multifaceted biocompatibility are required. We have synthesized a new polyurethane formulation with finely tuned mechanical properties, combining high strength and extensibility with a low Young's modulus...
April 24, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28432953/new-and-practical-mathematical-model-of-membrane-fouling-in-an-aerobic-submerged-membrane-bioreactor
#2
Mst Fazana Rahman Zuthi, Wenshan Guo, Huu Hao Ngo, Duc Long Nghiem, Faisal I Hai, Siqing Xia, Jianxin Li, Jixiang Li, Yi Liu
This study aimed to develop a practical semi-empirical mathematical model of membrane fouling that accounts for cake formation on the membrane and its pore blocking as the major processes of membrane fouling. In the developed model, the concentration of mixed liquor suspended solid is used as a lumped parameter to describe the formation of cake layer including the biofilm. The new model considers the combined effect of aeration and backwash on the foulants' detachment from the membrane. New exponential coefficients are also included in the model to describe the exponential increase of transmembrane pressure that typically occurs after the initial stage of an MBR operation...
April 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28431336/beam-induced-back-streaming-electron-suppression-analysis-for-an-accelerator-type-neutron-generator-designed-for-40-ar-39-ar-geochronology
#3
Cory Waltz, Mauricio Ayllon, Tim Becker, Lee Bernstein, Ka-Ngo Leung, Leo Kirsch, Paul Renne, Karl Van Bibber
A facility based on a next-generation, high-flux D-D neutron generator has been commissioned and it is now operational at the University of California, Berkeley. The current generator designed for (40)Ar/(39)Ar dating of geological materials produces nearly monoenergetic 2.45MeV neutrons at outputs of 10(8)n/s. The narrow energy range is advantageous relative to the (235)U fission spectrum neutrons due to (i) reduced (39)Ar recoil energy, (ii) minimized production of interfering argon isotopes from K, Ca, and Cl, and (iii) reduced total activity for radiological safety and waste generation...
April 13, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28430977/deep-mining-heterogeneous-networks-of-biomedical-linked-data-to-predict-novel-drug-target-associations
#4
Nansu Zong, Hyeoneui Kim, Victoria Ngo, Olivier Harismendy
Motivation: A heterogeneous network topology possessing abundant interactions between biomedical entities has yet to be utilized in similarity-based methods for predicting drug-target associations based on the array of varying features of drugs and their targets. Deep learning reveals features of vertices of a large network that can be adapted in accommodating the similarity-based solutions to provide a flexible method of drug-target prediction. Results: We propose a similarity-based drug-target prediction method that enhances existing association discovery methods by using a topology-based similarity measure...
April 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28429746/the-small-g-protein-arf6-expressed-in-keratinocytes-by-hgf-stimulation-is-a-regulator-for-skin-wound-healing
#5
Yuki Miura, Van Ngo Thai Bich, Momoko Furuya, Hiroshi Hasegawa, Satoru Takahashi, Naohiro Katagiri, Tsunaki Hongu, Yuji Funakoshi, Norihiko Ohbayashi, Yasunori Kanaho
The earlier step of cutaneous wound healing process, re-epithelialization of the wounded skin, is triggered by a variety of growth factors. However, molecular mechanisms through which growth factors trigger skin wound healing are less understood. Here, we demonstrate that hepatocyte growth factor (HGF)/c-Met signaling-induced expression of the small G protein Arf6 mRNA in keratinocytes is essential for the skin wound healing. Arf6 mRNA expression was dramatically induced in keratinocytes at the wounded skin, which was specifically suppressed by the c-Met inhibitor...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28427378/assessment-of-cardiac-function-in-children-with-congenital-adrenal-hyperplasia-a-case-control-study-in-cameroon
#6
J Tony Nengom, S Sap Ngo Um, D Chelo, R Mbono Betoko, J Boombhi, F Mouafo Tambo, A Chiabi, S Kingue, P Koki Ndombo
BACKGROUND: High level of androgens found in congenital adrenal hyperplasia (CAH) seems to have a deleterious effect on heart function. We therefore evaluate cardiac function of children with CAH in comparison with a healthy group. METHODS: We carried out a case-control study in the single endocrinology unit of the Mother and Child Center of Chantal Biya's Foundation. Cases were matched for age and genotypic sex to 2 healthy controls. We analyzed the ejection fraction (LVEF), fractional shortening and left ventricular mass; output and cardiac index; E and A waves velocities, E/A ratio and the mitral deceleration time and diameter of the left atrium; tricuspid annular plane systolic excursion and pulmonary artery systolic pressure were also measured...
April 20, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28417361/methods-for-determining-glycosyltransferase-kinetics
#7
Maria Ngo, Michael D L Suits
Glycosyltransferases are a class of biosynthetic enzymes that transfer individual activated monosaccharide units to specific acceptors. Colorimetric assays using the detection of released products such as para-nitrophenol and coupled assays for inorganic phosphate detection allow for convenient and quantifiable kinetic characterization. These techniques may be applied to determine the enzymatic activity of glycosyltransferases by indirectly measuring the transfer of nucleotide-activated donor carbohydrate units to various cognate acceptor molecules...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28416438/nsaid-use-in-intervertebral-disc-degeneration-what-are-the-effects-on-matrix-homeostasis-in-vivo
#8
Nicholas Vaudreuil, Tiffany Kadow, Takashi Yurube, Robert Hartman, Kevin Ngo, Qing Dong, Pedro Pohl, J Paulo Coelho, James Kang, Nam Vo, Gwendolyn Sowa
BACKGROUND CONTEXT: Non-steroidal anti-inflammatory (NSAID) agents are a widely utilized treatment for low back pain (LBP). Literature on NSAID use in articular cartilage has shown detrimental effects; however, minimal data exist to detail the effects of NSAIDs in intervertebral disc degeneration (IDD). As IDD is a major cause of LBP, we explored the effects of indomethacin, a commonly used NSAID, on disc matrix homeostasis in an animal model of IDD. PURPOSE: To determine the effects of oral indomethacin administration on IDD in an in vivo rabbit model...
April 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28411232/wnt5a-regulates-adipose-tissue-angiogenesis-via-anti-angiogenic-vegfa165b-in-obese-humans
#9
Shakun Karki, Doan Ngo, Melissa G Farb, Song-Young Park, Samantha M Saggese, Naomi M Hamburg, Brian Carmine, Donald T Hess, Kenneth Walsh, Noyan Gokce
Experimental studies suggest that Wingless-related integration site 5a (WNT5A) is a pro-inflammatory secreted protein that is associated with metabolic dysfunction in obesity. Impaired angiogenesis in fat has been implicated in the development of adipose tissue capillary rarefaction, hypoxia, inflammation and metabolic dysfunction. We recently demonstrated that impaired adipose tissue angiogenesis is associated with overexpression of anti-angiogenic factor VEGF-A165b in human fat and the systemic circulation...
April 14, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28411164/high-levels-of-local-inter-and-intra-host-genetic-variation-of-west-nile-virus-and-evidence-of-fine-scale-evolutionary-pressures
#10
Dylan J Ehrbar, Kiet A Ngo, Scott R Campbell, Laura D Kramer, Alexander T Ciota
West Nile virus (WNV; Flaviviridae, Flavivirus) has been endemic in New York State (NYS) since its 1999 introduction, yet prevalence in Culex mosquitoes varies substantially over small spatial and temporal scales. It is unclear if viral genetics plays a role in this variability, as genetic and phenotypic characterization on local scales has generally been lacking. In addition, intrahost diversity of circulating strains have not been fully characterized despite the documented role of minority variants in viral fitness and virulence...
April 12, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28409254/pediatric-brain-mri-part-1-basic-techniques
#11
REVIEW
Mai-Lan Ho, Norbert G Campeau, Thang D Ngo, Unni K Udayasankar, Kirk M Welker
Pediatric neuroimaging is a complex and specialized field that uses magnetic resonance (MR) imaging as the workhorse for diagnosis. Standard MR techniques used in adult neuroimaging are suboptimal for imaging in pediatrics because there are significant differences in the child's developing brain. These differences include size, myelination and sulcation. MR protocols need to be tailored to the specific indication and reviewed by the supervising radiologist in real time, and the specialized needs of this population require careful consideration of issues such as scan timing, sequence order, sedation, anesthesia and gadolinium administration...
May 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28409252/pediatric-brain-mri-part-2-advanced-techniques
#12
REVIEW
Mai-Lan Ho, Norbert G Campeau, Thang D Ngo, Unni K Udayasankar, Kirk M Welker
Pediatric neuroimaging is a complex and specialized field that uses magnetic resonance (MR) imaging as the workhorse for diagnosis. MR protocols should be tailored to the specific indication and reviewed by the supervising radiologist in real time. Targeted advanced imaging sequences can be added to provide information regarding tissue microstructure, perfusion, metabolism and function. In part 2 of this review, we highlight the utility of advanced imaging techniques for superior evaluation of pediatric neurologic disease...
May 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28408638/blindfolding-during-wakefulness-causes-decrease-in-sleep-slow-wave-activity
#13
Eva Magdalena Korf, Matthias Mölle, Jan Born, Hong-Viet V Ngo
Slow wave activity (SWA, 0.5-4 Hz) represents the predominant EEG oscillatory activity during slow wave sleep (SWS). Its amplitude is considered in part a reflection of synaptic potentiation in cortical networks due to encoding of information during prior waking, with higher amplitude indicating stronger potentiation. Previous studies showed that increasing and diminishing specific motor behaviors produced corresponding changes in SWA in the respective motor cortical areas during subsequent SWS Here, we tested whether this relationship can be generalized to the visual system, that is, whether diminishing encoding of visual information likewise leads to a localized decrease in SWA over the visual cortex...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28406734/effects-of-trang-phuc-linh-plus-food-supplement-on-irritable-bowel-syndrome-induced-by-mustard-oil
#14
Thong T Nguyen, Duong T Dau, Dung C Nguyen, Huong T T G Nguyen, Phuong T B Ngo, Thai Q Nguyen, Bo Han, Ba X Hoang
Trang phuc linh plus (TPLP) is a food supplement product derived from dried extracts of herbal agents Atractylodes macrocephala, Poria cocos, Paeonia lactiflora, Phellodendron amurense, and added lactobacillus fermentum lysate (ImmuneGamma(®)) and 5-hydroxytryptophan. TPLP is a functional food used as adjunctive treatment for treating irritable bowel syndrome (IBS). However the biological effect and its mechanism of action in IBS have not been elucidated. In this study, we aimed to determine the pharmacological activities and mode of action of TPLP on IBS animal models...
April 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28404785/moving-past-the-problematisation-of-tobacco-farming-insights-from-south-india
#15
Nithya Natarajan
INTRODUCTION: Tobacco control actors increasingly recognise the importance of supply-side issues in seeking to address the problem of global tobacco consumption. However, research in this field often depicts tobacco production as a problem for farmers and as a malaise of the global industry. This paper the case of chewing tobacco producers in South India to explore why tobacco remains so resilient in this region. METHODS: Semi-structured interviews with 68 tobacco farmers and traders in 38 villages across five districts of Tamil Nadu, triangulated with informal discussions with over 100 agrarian actors both connected and unconnected to tobacco, extensive ethnographic field notes, and interviews with state and NGO actors...
April 12, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28404592/accounting-for-oxygen-in-the-renal-cortex-a-computational-study-of-factors-that-predispose-the-cortex-to-hypoxia
#16
Chang-Joon Lee, Bruce S Gardiner, Jennifer P Ngo, Saptarshi Kar, Roger G Evans, David W Smith
We develop a pseudo-3D model of oxygen transport for the renal cortex of the rat, incorporating both the axial and radial geometry of the pre-glomerular circulation and quantitative information regarding the surface areas and transport from the vasculature and renal corpuscles. The computational model was validated by simulating four sets of published experimental studies of renal oxygenation in rats. Under the control conditions, the predicted cortical tissue oxygen tension (PtO2) or microvascular oxygen tension (µPO2) were within ± 1 standard error of the mean value (SEM) observed experimentally...
April 12, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28404512/a-new-approach-for-concurrently-improving-performance-of-south-korean-food-waste-valorization-and-renewable-energy-recovery-via-dry-anaerobic-digestion-under-mesophilic-and-thermophilic-conditions
#17
Dinh Duc Nguyen, Jeong Seong Yeop, Jaehoon Choi, Sungsu Kim, Soon Woong Chang, Byong-Hun Jeon, Wenshan Guo, Huu Hao Ngo
Dry semicontinuous anaerobic digestion (AD) of South Korean food waste (FW) under four solid loading rates (SLRs) (2.30-9.21kg total solids (TS)/m(3)day) and at a fixed TS content was compared between two digesters, one each under mesophilic and thermophilic conditions. Biogas production and organic matter reduction in both digesters followed similar trends, increasing with rising SLR. Inhibitor (intermediate products of the anaerobic fermentation process) effects on the digesters' performance were not observed under the studied conditions...
April 9, 2017: Waste Management
https://www.readbyqxmd.com/read/28403902/phylodynamics-of-foot-and-mouth-disease-virus-o-panasia-in-vietnam-2010-2014
#18
Barbara Brito, Steven J Pauszek, Michael Eschbaumer, Carolina Stenfeldt, Helena C de Carvalho Ferreira, Le T Vu, Nguyen T Phuong, Bui H Hoang, Nguyen D Tho, Pham V Dong, Phan Q Minh, Ngo T Long, Donald P King, Nick J Knowles, Do H Dung, Luis L Rodriguez, Jonathan Arzt
Foot-and-mouth disease virus (FMDV) is endemic in Vietnam, a country that plays an important role in livestock trade within Southeast Asia. The large populations of FMDV-susceptible species in Vietnam are important components of food production and of the national livelihood. In this study, we investigated the phylogeny of FMDV O/PanAsia in Vietnam, reconstructing the virus' ancestral host species (pig, cattle or buffalo), clinical stage (subclinical carrier or clinically affected) and geographical location...
April 13, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28403842/outcomes-of-autologous-bone-marrow-mononuclear-cells-for-cerebral-palsy-an-open-label-uncontrolled-clinical-trial
#19
Liem Thanh Nguyen, Anh Tuan Nguyen, Chinh Duy Vu, Doan V Ngo, Anh V Bui
BACKGROUND: Stem cell therapy has emerged as a promising method for improving motor function of patients with cerebral palsy. The aim of this study is to assess the safety and effectiveness of autologous bone marrow mononuclear stem cell transplantation in patients with cerebral palsy related to oxygen deprivation. METHODS: An open label uncontrolled clinical trial was carried out at Vinmec International Hospital. The intervention consisted of two administrations of stem cells, the first at baseline and the second 3 months later...
April 12, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28402906/applying-fermentation-liquid-of-food-waste-as-carbon-source-to-a-pilot-scale-anoxic-oxic-membrane-bioreactor-for-enhancing-nitrogen-removal-microbial-communities-and-membrane-fouling-behaviour
#20
Jialing Tang, Xiaochang C Wang, Yisong Hu, Huu Hao Ngo, Yuyou Li, Yongmei Zhang
Fermentation liquid of food waste (FLFW) was applied as an external carbon source in a pilot-scale anoxic/oxic-membrane bioreactor (A/O-MBR) system to enhance nitrogen removal for treating low COD/TN ratio domestic wastewater. Results showed that, with the FLFW addition, total nitrogen removal increased from lower than 20% to 44-67% during the 150days of operation. The bacterial metabolic activities were obviously enhanced, and the significant change in microbial community structure promoted pollutants removal and favored membrane fouling mitigation...
April 2, 2017: Bioresource Technology
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