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https://www.readbyqxmd.com/read/29148698/chelator-free-conjugation-of-99mtc-and-gd3-to-pegylated-nanographene-oxide-for-dual-modality-spect-mr-imaging-of-lymph-nodes
#1
Tianye Cao, Xiaobao Zhou, Yingying Zheng, Yuyun Sun, Jian Zhang, Wei Chen, Jianping Zhang, Zhiguo Zhou, Shi-Ping Yang, Yingjian Zhang, Hong Yang, Ming-Wei Wang
PEGylated ultra-small nanographene oxide (usNGO-PEG) has exhibited great potential in nanotheranostics due to its newly-discovered physicochemical properties derived from the rich functional groups and  bonds. Herein, we developed a general, simple and kit-like preparation approach for 99mTcI- and Gd-anchored NGO-PEG using a chelator-free strategy. In this strategy, [99mTcI(CO)3(OH2)3]+ (abbreviated to 99mTcI) and GdCl3 were mixed with usNGO-PEG to yield 99mTc- and Gd-usNGO-PEG via the synergistic coordination of N and O atoms from NGO and PEG with 99mTcI and Gd3+ without additional exogenous chelators...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148237/supraclavicular-flap-repair-in-the-free-flap-era
#2
REVIEW
Jodie Trautman, Sinclair Gore, Matthew Potter, Jonathan Clark, Dylan Hyam, Ngian C Tan, Quan Ngo, Bruce Ashford
BACKGROUND: Supraclavicular flap (SCF) repair is widely reported in head and neck surgery in select patients and defects. The authors' objective is to present our series of 30 patients who underwent SCF repair for varying defects and to review the scope and outcome of SCF repair in the literature. METHODS: The authors contributed primary evidence of 30 cases of SCF repair. Our outcomes are compared with those reported in the last 5 years' literature; 33 articles published between January 2012 and January 2017 that present original clinical experience of 528 SCFs...
November 17, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29145038/precision-medicine-for-patients-with-advanced-biliary-tract-cancers-an-effective-strategy-within-the-prospective-moscato-01-trial
#3
Loic Verlingue, David Malka, Adrien Allorant, Christophe Massard, Charles Ferté, Ludovic Lacroix, Etienne Rouleau, Nathalie Auger, Maud Ngo, Claudio Nicotra, Thierry De Baere, Lambros Tselikas, Bakar Ba, Stefan Michiels, Jean-Yves Scoazec, Valérie Boige, Michel Ducreux, Jean-Charles Soria, Antoine Hollebecque
BACKGROUND: Recommended treatments of patients with advanced biliary tract cancer (aBTC) are limited to one chemotherapy doublet. Nevertheless, efficacy of treatment personalisation for aBTCs is supported by accumulating evidences but remains to be evaluated. PATIENTS AND METHODS: Patients with aBTCs included in the prospective clinical trial MOSCATO-01 were treated by at least one previous systemic treatment, had an ECOG performance status of 0-1, and at least one tumour site accessible to biopsy...
November 13, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29144976/single-cell-profiling-of-an-in%C3%A2-vitro-model-of-human-interneuron-development-reveals-temporal-dynamics-of-cell-type-production-and-maturation
#4
Jennie L Close, Zizhen Yao, Boaz P Levi, Jeremy A Miller, Trygve E Bakken, Vilas Menon, Jonathan T Ting, Abigail Wall, Anne-Rachel Krostag, Elliot R Thomsen, Angel M Nelson, John K Mich, Rebecca D Hodge, Soraya I Shehata, Ian A Glass, Susan Bort, Nadiya V Shapovalova, N Kiet Ngo, Joshua S Grimley, John W Phillips, Carol L Thompson, Sharad Ramanathan, Ed Lein
No abstract text is available yet for this article.
November 15, 2017: Neuron
https://www.readbyqxmd.com/read/29143572/socio-economic-integration-of-the-informal-recycling-sector-through-an-ngo-intervention-at-the-andralanitra-dumpsite-in-antananarivo-madagascar
#5
Harinaivo A Andrianisa, Fanilo M Randriatsiferana, Serge L Rakotoson, Fanja Rakotoaritera
The social status improvement and the degree of integration of the informal recycling sector, by using InteRa, made by the AKAMASOA association interventions at the Andralanitra dumpsite (Antananarivo, Madagascar) was assessed. 20% of the workers from the three activities at the site were interviewed: 325 scavengers, 12 compost producers and three soap manufacturers. It was found that the incomes of Andralanitra workers are relatively low compared to that of people working in the same field in other countries (30-60 USD/month)...
November 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/29137673/a-cheap-and-open-hiv-viral-load-technique-applicable-in-routine-analysis-in-a-resource-limited-setting-with-a-wide-hiv-genetic-diversity
#6
Elodie Téclaire Ngo-Malabo, Paul Alain Ngoupo T, Martin Zekeng, Valérie Ngono, Laure Ngono, Serge Alain Sadeuh-Mba, Richard Njouom, Anfumbom Kfutwah
BACKGROUND: HIV infection in Cameroon is characterized by a great viral diversity with all HIV-1 groups (M, N, O, and P) and HIV-2 in circulation. HIV group determination is very important if tailored viral load analysis and treatments are to be applied. In our laboratory, HIV viral load is carried out using two platforms; Biocentric and Abbott depending on the HIV group identified. Biocentric which quantifies HIV-1 group M is a cheap and open system useful in resource limited settings...
November 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/29131583/constant-ph-accelerated-molecular-dynamics-investigation-of-the-ph-regulation-mechanism-of-dinoflagellate-luciferase
#7
Patrick H Donnan, Phong Duy Ngo, Steven O Mansoorabadi
The bioluminescence reaction in dinoflagellates involves the oxidation of an open-chain tetrapyrrole by the enzyme dinoflagellate luciferase (LCF). The activity of LCF is tightly regulated by pH, where the enzyme is essentially inactive at pH ~ 8 and optimally active at pH ~ 6. Little is known about the mechanism of LCF and the structure of the active form of the enzyme, although it has been proposed that several intramolecularly conserved histidine residues in the N-terminal region are important for the pH regulation mechanism...
November 13, 2017: Biochemistry
https://www.readbyqxmd.com/read/29130006/incidental-laparoscopic-discovery-of-an-intraperitoneal-plastic-catheter-16-years-after-an-unsafe-abortion-a-case-report-from-the-gynecologic-obstetric-and-pediatric-hospital-of-yaound%C3%A3-cameroon
#8
Ngandji Andre, Ngo Um Meka Esther Juliette, Fokom Joel, Wandji Brigitte, Foumane Pascal
In many developing countries like Cameroon, unsafe abortion is a major public health problem. It can be responsible for severe complications including damage to the digestive and/or urinary tract, sepsis, and uterine perforation. Uterine perforation could be caused by most of the instruments that are used to evacuate the uterus. We report a case of apparent uterine perforation and subsequent migration of the plastic or rubber catheter into the peritoneal cavity during an abortion procedure performed in a setting that may have been unsafe...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29127730/comprehensive-study-of-three-novel-cases-of-tfeb-amplified-renal-cell-carcinoma-and-review-of-the-literature-evidence-for-a-specific-entity-with-poor-outcome
#9
Lionel Mendel, Damien Ambrosetti, Yohan Bodokh, Mélanie Ngo-Mai, Matthieu Durand, Cécile Simbsler-Michel, Mickael Delhorbe, Jean Amiel, Florence Pedeutour
The first case of TFEB-amplified renal cell carcinoma was published in 2014. Since then, 29 additional cases have been described. The prognostic and therapeutic implications of this rare entity remain to be determined. We describe here the clinical, histological and genetic features of three novel cases, as well as the first complete literature review. Four tumors were examined from three patients selected from the large collection of genetically characterized renal tumors in our institution. The pathological and immunohistochemical features were centrally reviewed by a uropathologist...
November 11, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29127343/global-phylogenetic-analysis-of-escherichia-coli-and-plasmids-carrying-the-mcr-1-gene-indicates-bacterial-diversity-but-plasmid-restriction
#10
Sébastien Matamoros, Jarne M van Hattem, Maris S Arcilla, Niels Willemse, Damian C Melles, John Penders, Trung Nguyen Vinh, Ngo Thi Hoa, Menno D de Jong, Constance Schultsz
To understand the dynamics behind the worldwide spread of the mcr-1 gene, we determined the population structure of Escherichia coli and of mobile genetic elements (MGEs) carrying the mcr-1 gene. After a systematic review of the literature we included 65 E. coli whole genome sequences (WGS), adding 6 recently sequenced travel related isolates, and 312 MLST profiles. We included 219 MGEs described in 7 Enterobacteriaceae species isolated from human, animal and environmental samples. Despite a high overall diversity, 2 lineages were observed in the E...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126808/innovative-vaccine-delivery-strategies-in-response-to-a-cholera-outbreak-in-the-challenging-context-of-lake-chilwa-a-rapid-qualitative-assessment
#11
Leonard W Heyerdahl, Bagrey Ngwira, Rachel Demolis, Gabriel Nyirenda, Maurice Mwesawina, Florentina Rafael, Philippe Cavailler, Jean Bernard Le Gargasson, Martin A Mengel, Bradford D Gessner, Elise Guillermet
A reactive campaign using two doses of Shanchol Oral Cholera Vaccine (OCV) was implemented in 2016 in the Lake Chilwa Region (Malawi) targeting fish dependent communities. Three strategies for the second vaccine dose delivery (including delivery by a community leader and self-administration) were used to facilitate vaccine access. This assessment collected vaccine perceptions and opinions about the OCV campaign of 313 study participants, including: fishermen, fish traders, farmers, community leaders, and one health and one NGO officer...
November 7, 2017: Vaccine
https://www.readbyqxmd.com/read/29124454/evaluating-the-effectiveness-of-community-and-hospital-medical-record-integration-on-management-of-behavioral-health-in-the-emergency-department
#12
Stephanie Ngo, Mohammad Shahsahebi, Sean Schreiber, Fred Johnson, Mina Silberberg
This study evaluated the correlation of an emergency department embedded care coordinator with access to community and medical records in decreasing hospital and emergency department use in patients with behavioral health issues. This retrospective cohort study presents a 6-month pre-post analysis on patients seen by the care coordinator (n=524). Looking at all-cause healthcare utilization, care coordination was associated with a significant median decrease of one emergency department visit per patient (p < 0...
November 9, 2017: Journal of Behavioral Health Services & Research
https://www.readbyqxmd.com/read/29122935/in-vivo-measurements-of-interindividual-differences-in-dna-glycosylases-and-ape1-activities
#13
Isaac A Chaim, Zachary D Nagel, Jennifer J Jordan, Patrizia Mazzucato, Le P Ngo, Leona D Samson
The integrity of our DNA is challenged with at least 100,000 lesions per cell on a daily basis. Failure to repair DNA damage efficiently can lead to cancer, immunodeficiency, and neurodegenerative disease. Base excision repair (BER) recognizes and repairs minimally helix-distorting DNA base lesions induced by both endogenous and exogenous DNA damaging agents. Levels of BER-initiating DNA glycosylases can vary between individuals, suggesting that quantitating and understanding interindividual differences in DNA repair capacity (DRC) may enable us to predict and prevent disease in a personalized manner...
November 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29120291/how-they-see-it-young-women-s-views-on-early-marriage-in-a-post-conflict-setting
#14
Sonya Em Knox
Current understandings of early marriage in conflict and post-conflict settings are incomplete and under-researched, and do not sufficiently take into consideration the views and experiences of adolescent girls. While much of the literature, development reports and mainstream media emphasise the poverty, health risks and lack of agency of young women married early, they seldom provide these teenagers an open platform from which to speak. In 2007, a Palestinian refugee camp in North Lebanon was destroyed and its residents forced to flee...
October 2017: Reproductive Health Matters
https://www.readbyqxmd.com/read/29119872/adapting-operational-research-training-to-the-rwandan-context-the-intermediate-operational-research-training-programme
#15
Jackline Odhiambo, Cheryl L Amoroso, Peter Barebwanuwe, Christine Warugaba, Bethany L Hedt-Gauthier
BACKGROUND: Promoting national health research agendas in low- and middle-income countries (LMICs) requires adequate numbers of individuals with skills to initiate and conduct research. Recently, non-governmental organizations (NGOs) have joined research capacity building efforts to increase research leadership by LMIC nationals. Partners In Health, an international NGO operating in Rwanda, implemented its first Intermediate Operational Research Training (IORT) course to cultivate Rwandan research talent and generate evidence to improve health care delivery...
2017: Global Health Action
https://www.readbyqxmd.com/read/29119263/electronic-properties-of-the-polypyrrole-dopant-anions-clo4-and-moo4-2-a-density-functional-theory-study
#16
Nguyen Ngoc Ha, Ngo Tuan Cuong, Hoang Van Hung, Ha Manh Hung, Vu Quoc Trung
The conductive properties of polypyrrole chains doped with ClO4(-) or MoO4(2-) anions and the existence of polarons and bipolarons in these doped polypyrrole chains were investigated by performing computational calculations based on density functional theory (DFT). Doping with these anions was found to decrease the band gap of the polypyrrole. Theoretical calculations revealed that changing the type of oxidative agent applied does not affect the conversion of polypyrrole into a conducting polymer, but the conductivity of the doped polypyrrole does depend on the ratio of oxidant to polypyrrole...
November 8, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29117194/a-pre-operative-predictive-score-to-evaluate-the-feasibility-of-complete-cytoreductive-surgery-in-patients-with-epithelial-ovarian-cancer
#17
Marion Chesnais, Fabrice Lecuru, Myriam Mimouni, Charlotte Ngo, Arnaud Fauconnier, Cyrille Huchon
OBJECTIVE: Postoperative residual tumor is the major prognostic factor in ovarian cancer. The feasibility of complete cytoreductive surgery is assessed by laparoscopy. Our goal was to develop a predictive score prior to laparoscopy to evaluate the feasibility of complete cytoreductive surgery in patients with epithelial ovarian cancer. METHODS: We developed a score to predict incomplete cytoreductive surgery by performing multiple logistic regressions after bootstrap procedures on data from a retrospective cohort of 247 patients with advanced ovarian cancer...
2017: PloS One
https://www.readbyqxmd.com/read/29111908/misuse-of-antenatal-care-and-its-association-with-adverse-outcomes-of-pregnancy-in-a-southern-rural-area-of-vietnam
#18
Thi-Thuy-Dung Ngo, The-Dung Nguyen, Philippe Goyens, Annie Robert
Researchers in Vietnam reported a high percentage of pregnant women attending ANC at least once, but an insufficient utilization of ANC services remains. The evidence demonstrating how the utilization of these services affect pregnancy outcome is not documented in Vietnam. We investigated the association between the misuse of ANC services and pregnancy outcome, and assessed other determinants associated with ANC services utilization. We conducted a prospective community-based study in Trang Bom district, Dong Nai, during 12 consecutive months...
November 7, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/29110709/the-prevalence-incidence-and-prevention-of-plasmodium-falciparum-infections-in-forest-rangers-in-bu-gia-map-national-park-binh-phuoc-province-vietnam-a-pilot-study
#19
Do Hung Son, Nguyen Thuy-Nhien, Lorenz von Seidlein, Truong Le Phuc-Nhi, Ngo Thi Phu, Nguyen Thi Kim Tuyen, Nguyen Huyen Tran, Nguyen Van Dung, Bui Van Quan, Nicholas P J Day, Arjen M Dondorp, Nicholas J White, Guy E Thwaites, Tran Tinh Hien
BACKGROUND: Prophylaxis for high-risk populations, such as forest workers, could be one component for malaria elimination in the Greater Mekong Sub-region. A study was conducted to assess the malaria incidence in forest rangers and the feasibility of malaria prophylaxis for rangers sleeping in forest camps. METHODS: Forest rangers deployed in the Bu Gia Map National Park, Vietnam were invited to participate in the study. Plasmodium infections were cleared using presumptive treatment, irrespective of malaria status, with a 3-day course dihydroartemisinin/piperaquine (DP) and a 14-day course of primaquine...
November 6, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29107122/ebola-ag-k-set-rapid-test-field-evaluation-in-sierra-leone
#20
Francesca Colavita, Mirella Biava, Pascal Mertens, Quentin Gilleman, Céline Borlon, Michela Delli Guanti, Antonio Petrocelli, Gianluca Cataldi, Alhaji T Kamara, Santige A Kamara, Kelfala Konneh, Donatella Vincenti, Concetta Castilletti, Samir Abdurahman, Ali Mirazimi, Maria Rosaria Capobianchi, Giuseppe Ippolito, Rossella Miccio, Antonino Di Caro
OBJECTIVES: Efficient interruption of Ebola virus disease (EVD) transmission chains critically depends on reliable and fast laboratory diagnosis. We evaluated the performance of the EBOLA Virus Antigen Detection K-SeT (EBOLA Ag K-SeT), a new rapid diagnostic antigen test (RDT)in field settings. METHODS: The study was conducted in a field laboratory located in Freetown (Sierra Leone) by the Italian National Institute for Infectious Diseases "L. Spallanzani" and EMERGENCY Onlus NGO...
October 26, 2017: Clinical Microbiology and Infection
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