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https://www.readbyqxmd.com/read/29353423/polymerase-chain-reaction-based-detection-of-myc-transduction-in-feline-leukemia-virus-infected-cats
#1
Ryosuke Sumi, Ariko Miyake, Taiji Endo, Yoshiharu Ohsato, Minh Ha Ngo, Kazuo Nishigaki
Feline lymphomas are associated with the transduction and activation of cellular proto-oncogenes, such as c-myc, by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of myc transduction usable in clinical diagnosis. The assay targets c-myc exons 2 and 3, which together result in a FeLV-specific fusion gene following c-myc transduction. When this assay was conducted on FeLV-infected feline tissues submitted for clinical diagnosis of tumors, myc transduction was detected in 14% of T-cell lymphoma/leukemias...
January 20, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29349857/a-diazido-mannose-analog-as-a-chemoenzymatic-synthon-for-synthesizing-di-n-acetyllegionaminic-acid-containing-glycosides
#2
Abhishek Santra, An Xiao, Hai Yu, Wanqing Li, Yanhong Li, Linh Ngo, John B McArthur, Xi Chen
A novel strategy is developed to expand the scope of chemoenzymatic synthetic products by designing a chemoenzymatic synthon. The synthon is enzymatically converted to carbohydrate analogs which are readily derivatized chemically to produce desired targets. The strategy is demonstrated for synthesizing glycosides containing 7,9-di-N-acetyllegionaminic acid (Leg5,7Ac2), a bacterial nonulosonic acid (NulO) analog of sialic acid. A versatile library of a2-3/6-linked Leg5,7Ac2- glycosides is built using chemically synthesized 2,4-diazido-2,4,6-trideoxy mannose as a chemoenzymatic synthon for highly efficient one-pot multienzyme (OPME) sialylation followed by a downstream chemical conversion of the azido group to an acetamido group...
January 19, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29347926/handheld-ultrasound-to-avert-maternal-and-neonatal-deaths-in-2-regions-of-the-philippines-an-ibuntis%C3%A2-intervention-study
#3
Godofreda V Dalmacion, Ramon T Reyles, Antonia E Habana, Lalaine Mae V Cruz, Maricelle C Chua, Analyn T Ngo, Milagros J Tia-Jocson, Emmanuel S Baja
BACKGROUND: The major causes of maternal and neonatal mortality in the Philippines are hemorrhages and obstructed labor due to placental implantation abnormalities (PIAs), twin pregnancies and fetal malpresentations. All of which are all easily detected by ultrasound. However, women in rural areas and low-income groups do not have access to ultrasound during their prenatal care. We aimed to provide additional evidence on the benefits of handheld ultrasound (HU) for screening pregnancy related abnormalities in order to avert maternal and neonatal deaths...
January 18, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29344311/gilz-activin-a-as-a-novel-signaling-axis-orchestrating-mesenchymal-stem-cell-and-th17-cell-interplay
#4
Patricia Luz-Crawford, Gabriel Espinosa-Carrasco, Natacha Ipseiz, Rafael Contreras, Gautier Tejedor, Daniel A Medina, Ana-Maria Vega-Letter, Devi Ngo, Eric F Morand, Jérôme Pène, Javier Hernandez, Christian Jorgensen, Farida Djouad
Mesenchymal stem cells (MSC) are highly immunosuppressive cells able to reduce chronic inflammation through the active release of mediators. Recently, we showed that glucocorticoid-induced leucine zipper (Gilz) expression by MSC is involved in their therapeutic effect by promoting the generation of regulatory T cells. However, the mechanisms underlying this pivotal role of Gilz remain elusive. Methods and Results In this study, we have uncovered evidence that Gilz modulates the phenotype and function of Th1 and Th17 cells likely by upregulating the level of Activin A and NO2 secreted by MSC...
2018: Theranostics
https://www.readbyqxmd.com/read/29342134/chromosomal-instability-drives-metastasis-through-a-cytosolic-dna-response
#5
Samuel F Bakhoum, Bryan Ngo, Ashley M Laughney, Julie-Ann Cavallo, Charles J Murphy, Peter Ly, Pragya Shah, Roshan K Sriram, Thomas B K Watkins, Neil K Taunk, Mercedes Duran, Chantal Pauli, Christine Shaw, Kalyani Chadalavada, Vinagolu K Rajasekhar, Giulio Genovese, Subramanian Venkatesan, Nicolai J Birkbak, Nicholas McGranahan, Mark Lundquist, Quincey LaPlant, John H Healey, Olivier Elemento, Christine H Chung, Nancy Y Lee, Marcin Imielenski, Gouri Nanjangud, Dana Pe'er, Don W Cleveland, Simon N Powell, Jan Lammerding, Charles Swanton, Lewis C Cantley
Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome segregation during mitosis. Although chromosomal instability is a major driver of tumour evolution, its role in metastasis has not been established. Here we show that chromosomal instability promotes metastasis by sustaining a tumour cell-autonomous response to cytosolic DNA. Errors in chromosome segregation create a preponderance of micronuclei whose rupture spills genomic DNA into the cytosol. This leads to the activation of the cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes) cytosolic DNA-sensing pathway and downstream noncanonical NF-κB signalling...
January 17, 2018: Nature
https://www.readbyqxmd.com/read/29341827/editorial-focus-multitasking-a-challenge-for-the-kidney-focus-on-red-blood-cell-antibody-induced-anemia-causes-differential-degrees-of-tissue-hypoxia-in
#6
Jennifer P Ngo, Roger G Evans
No abstract text is available yet for this article.
January 17, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29322899/is-the-pelvis-stable-during-supine-total-hip-arthroplasty
#7
S M Shah, W L Walter, J Ngo
Intra- operative changes in pelvic position during total hip arthroplasty (THA) can affect acetabular orientation. We evaluated these changes during supine THA using a proprietary mobile application called PelvicTracker. Twenty- two patients undergoing THA using direct anterior approach were included in the study. In the sagittal plane, the pelvis was extended (anterior tilt) as compared to the start of surgery in 19/ 22 hips at the time of cup implantation (mean extension: 3.1°; range: 1°-6°). In the transverse plane, the pelvis was rolled to the opposite side of surgery in 12 hips (mean roll: 2...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29317470/network-guided-discovery-of-extensive-epistasis-between-transcription-factors-involved-in-aliphatic-glucosinolate-biosynthesis
#8
Baohua Li, Michelle Tang, Ayla Nelson, Hart Caligagan, Xue Zhou, Caitlin Clark Wiest, Richard Ngo, Siobhan M Brady, Daniel J Kliebenstein
Plants use diverse mechanisms influenced by vast regulatory networks of indefinite scale to adapt to their environment. These regulatory networks have an unknown potential for epistasis between genes within and across networks. To test for epistasis within an adaptive trait genetic network, we generated and tested 47 Arabidopsis thaliana double mutant combinations for 20 transcription factors, which all influence the accumulation of aliphatic glucosinolates, the defense metabolites that control fitness. The epistatic combinations were used to test if there is more or less epistasis depending on gene membership within the same or different phenotypic sub-networks...
January 9, 2018: Plant Cell
https://www.readbyqxmd.com/read/29316919/use-of-an-electronic-medical-record-reminder-improves-hiv-screening
#9
Colleen Kershaw, Jessica L Taylor, Gary Horowitz, Diane Brockmeyer, Howard Libman, Gila Kriegel, Long Ngo
BACKGROUND: More than 1 in 7 patients with human immunodeficiency virus (HIV) infection in the United States are unaware of their serostatus despite recommendations of US agencies that all adults through age 65 be screened for HIV at least once. To facilitate universal screening, an electronic medical record (EMR) reminder was created for our primary care practice. Screening rates before and after implementation were assessed to determine the impact of the reminder on screening rates...
January 10, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29306943/clinically-observed-estrogen-receptor-alpha-mutations-within-the-ligand-binding-domain-confer-distinguishable-phenotypes
#10
Shanhang Jia, Mark T Miedel, Marilyn Ngo, Ryan Hessenius, Ning Chen, Peilu Wang, Amir Bahreini, Zheqi Li, Zhijie Ding, Tong Ying Shun, Daniel M Zuckerman, D Lansing Taylor, Shannon L Puhalla, Adrian V Lee, Steffi Oesterreich, Andrew M Stern
OBJECTIVE: Twenty to fifty percent of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain. While most studies focused on the constitutive ER signaling activity commonly engendered by these mutations selected during estrogen deprivation therapy, our study was aimed at investigating distinctive phenotypes conferred by different mutations within this class. METHODS: We examined the two most prevalent mutations, D538G and Y537S, employing corroborative genome-edited and lentiviral-transduced ER+ T47D cell models...
January 6, 2018: Oncology
https://www.readbyqxmd.com/read/29304470/protein-s-and-gas6-induce-efferocytosis-of-hiv-1-infected-cells
#11
Bernadette Anne Chua, Jamie Ann Ngo, Kathy Situ, Christina M Ramirez, Haruko Nakano, Kouki Morizono
Efferocytosis, the phagocytic clearance of apoptotic cells, can provide host protection against certain types of viruses by mediating phagocytic clearance of infected cells undergoing apoptosis. It is known that HIV-1 induces apoptosis and HIV-1-infected cells are efferocytosed by macrophages, although its molecular mechanisms are unknown. To elucidate the roles that efferocytosis of HIV-1-infected cells play in clearance of infected cells, we sought to identify molecules that mediate these processes. We found that protein S, present in human serum, and its homologue, Gas6, can mediate phagocytosis of HIV-1-infected cells by bridging receptor tyrosine kinase Mer, expressed on macrophages, to phosphatidylserine exposed on infected cells...
January 2, 2018: Virology
https://www.readbyqxmd.com/read/29303204/a-versatile-platform-for-the-highly-efficient-preparation-of-graphene-quantum-dots-photoluminescence-emission-and-hydrophilicity-hydrophobicity-regulation-and-organelle-imaging
#12
Xiaolong Wu, Liling Ma, Shan Sun, Kai Jiang, Ling Zhang, Yuhui Wang, Haibo Zeng, Hengwei Lin
In this work, a versatile platform for the highly efficient preparation of graphene quantum dots (GQDs) with diverse properties was developed. First of all, an excess amount of oxidants and an additional high temperature step of the Hummers' method for the synthesis of graphene oxide (GO) was applied to obtain nanosized graphene oxide (NGO). Then, high quality GQDs (quantum yields up to 18.2%) with different photoluminescence emission wavelengths, adjustable hydrophilicity-hydrophobicity, and selective cell organelle imaging capacity can be facilely achieved through a one-pot hydrothermal reaction between the NGO and ammonia, fatty primary amines, or amino-substituted organelle targetable compounds, respectively...
January 5, 2018: Nanoscale
https://www.readbyqxmd.com/read/29302617/genetic-pathways-of-neuroregeneration-in-a-novel-mild-traumatic-brain-injury-model-in-adult-zebrafish
#13
Amanda L Maheras, Brian Dix, Olivia M S Carmo, Aleena E Young, Vanessa N Gill, Julia L Sun, Aleah R Booker, Helen A Thomason, Anastasia E Ibrahim, Lauren Stanislaw, Jennifer C Dallego, Cat N Ngo, Audrey Chen, Barbara K Fortini, Rory D Spence
Mild traumatic brain injuries (mTBIs) are one of the most prevalent neurological disorders, and humans are severely limited in their ability to repair and regenerate central nervous system (CNS) tissue postinjury. However, zebrafish (Danio rerio) maintain the remarkable ability to undergo complete and functional neuroregeneration as an adult. We wish to extend knowledge of the known mechanisms of neuroregeneration by analyzing the differentially expressed genes (DEGs) in a novel adult zebrafish model of mTBI...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29301010/diminished-capsule-exacerbates-virulence-blood-brain-barrier-penetration-intracellular-persistence-and-antibiotic-evasion-of-hyperhemolytic-group-b-streptococcus
#14
Claire Gendrin, Sean Merillat, Jay Vornhagen, Michelle Coleman, Blair Armistead, Lisa Ngo, Anjali Aggarwal, Phoenicia Quach, Jacob Berrigan, Lakshmi Rajagopal
Group B Streptococcus (GBS) are encapsulated, β-hemolytic bacteria that are a common cause of infections in human newborns and certain adults. Two virulence factors important for GBS virulence are the sialic acid capsular polysaccharide that promotes immune evasion and the hemolytic pigment that induces host cell cytotoxcity. These virulence factors are often oppositely regulated by the CovR/CovS two-component system. Clinical GBS strains exhibiting hyperhemolysis and low capsule due to pathoadaptive covR/S mutations have been isolated from patients...
January 2, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29300311/the-suppressive-activity-of-fucofuroeckol-a-derived-from-brown-algal-ecklonia-stolonifera-okamura-on-uvb-induced-mast-cell-degranulation
#15
Thanh Sang Vo, Se-Kwon Kim, BoMi Ryu, Dai Hung Ngo, Na-Young Yoon, Long Giang Bach, Nguyen Thi Nhat Hang, Dai Nghiep Ngo
UV light, especially UVB, is known as a trigger of allergic reaction, leading to mast cell degranulation and histamine release. In this study, phlorotannin Fucofuroeckol-A (F-A) derived from brown algal Ecklonia stolonifera Okamura was evaluated for its protective capability against UVB-induced allergic reaction in RBL-2H3 mast cells. It was revealed that F-A significantly suppress mast cell degranulation via decreasing histamine release as well as intracellular Ca2+ elevation at the concentration of 50 μM...
January 4, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29299881/-xe-international-congress-of-the-soci%C3%A3-t%C3%A3-de-pathologie-exotique-8-9-november-2017-haiphong-vietnam-surgery-access-in-tropical-areas
#16
Y Buisson, P Guyon, Y Buisson, N Osinki, C Tamames, J Leconte, M Jarry, J Robert, C Dumurgier, O Choua, M O Ahmat, K M Moussa, D Sabe, A Telniaret, A M Rabo, N Kitoko, B Allatombaye, Duong Bunn, Nguyen Hong Dao, Le Duc Huy, Hoang Le Bich Ngoc, Le Hong Tram, Tran Van Khoi, Pham Van Thuc, Pham Van Linh, K Kourouma, F T Gerald, K Kourouma, P O Saibou, G C Ngunyi, B Wombe, P Alessandroni, R Andrei, J Delmont, C Gasiglia, V V Haï, M Heng, T Heng, C Khampho, D Mekhalfa, S Marcaggi, M Pimontipa, J-R Plotton, N A The Ngo, T Vilayphone, Tran Xuan Duong, Nguyen Lam Hoa, J-F Pays, P Buchy, C Goujon, O Bouchaud, P-H Consigny, L de Gentile, E D'Ortenzio, Ph Gautret, F Sorge, C Strady, E Pichard, C Haddar, E Bégaud, Mook Yun Yuh, Eng Lim Law, Y Germani, O Bouchaud, S Houze, J Chandenier, J Jannin, P Solano, I Quick, P Debre, P Guyon, A Ensaf, P Bourée, B Fabre-Teste, M El Mouden, G Soula
No abstract text is available yet for this article.
December 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/29298090/variation-in-the-diagnosis-of-aspiration-pneumonia-and-association-with-hospital-pneumonia-outcomes
#17
Peter K Lindenauer, Kelly M Strait, Jacqueline N Grady, Chi K Ngo, Madeline L Parisi, Mark Metersky, Joseph S Ross, Susannah M Bernheim, Karen Dorsey
Rationale National efforts to compare hospital outcomes for patients with pneumonia may be biased by hospital differences in diagnosis and coding of aspiration pneumonia, a condition that has traditionally been excluded from pneumonia outcome measures. Objectives To evaluate the rationale and impact of including aspiration pneumonia patients in hospital mortality and readmission measures. Methods Using Medicare fee-for-service claims for patients > 65 years from July 2012 - June 2015, we characterized the proportion of hospitals' pneumonia patients diagnosed with aspiration pneumonia, calculated hospital-specific risk-standardized rates of 30-day mortality and readmission for pneumonia patients, analyzed the association between aspiration pneumonia coding frequency and these rates, and re-calculated these rates including aspiration pneumonia patients...
January 3, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29297934/assessment-of-the-conservation-measures-partnership-s-effort-to-improve-conservation-outcomes-through-adaptive-management
#18
Kent H Redford, Kristin B Hulvey, Matthew Williamson, Mark W Schwartz
Conservation practice has demonstrated an increasing desire for accountability of actions, particularly with respect to effectiveness, efficiency, and impact to specified objectives. This has been accompanied by increased attention to achieving adaptive management. In 2003 practitioners representing several prominent conservation non-governmental organizations (NGO's) launched a community of practice called the Conservation Measures Partnership (CMP). This organization has worked to establish standards of conservation practice to improve accountability of conservation actions through adaptive management...
January 3, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29295891/a-peptidylic-inhibitor-for-neutralizing-expanded-cag-rna-induced-nucleolar-stress-in-polyglutamine-diseases
#19
Qian Zhang, Zhefan Stephen Chen, Ying An, Haizhen Liu, Yonghui Hou, Wen Li, Kwok-Fai Lau, Alex Koon, Jacky Ngo, Edwin Chan
Polyglutamine (polyQ) diseases are a set of progressive neurodegenerative disorders ascribed by the expression of both expanded CAG RNA and misfolded polyQ protein. We previously reported that the direct interaction between expanded CAG RNA and nucleolar protein nucleolin (NCL) leads to impediment of pre-ribosomal RNA (pre-rRNA) transcription, and eventually triggers nucleolar stress-induced apoptosis in polyQ diseases. Here, we report a 21-amino acid peptide, named beta-structured inhibitor for neurodegenerative disease (BIND), effectively suppresses expanded CAG RNA toxicity...
January 2, 2018: RNA
https://www.readbyqxmd.com/read/29294643/gender-norms-and-beliefs-and-men-s-violence-against-women-in-rural-bangladesh
#20
Kazi Nazrul Fattah, Suborna Camellia
Prevention of violence against women requires understanding men's controlling attitudes and behaviors toward women. In Bangladesh, while the incidence of men's violence against women is alarmingly increasing, existing research to understand the determinants of men's violent behavior resulted in contradictory findings. The current study explores rural Bangladeshi men's support for gender norms, beliefs, and attitudes concerning violence against women, and looks at how these are influenced by men's age, marital status, education, and affiliation with organizations that promote gender equality...
February 1, 2017: Journal of Interpersonal Violence
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