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https://www.readbyqxmd.com/read/29792849/the-role-and-mechanism-of-k-ca-3-1-channels-in-human-monocyte-migration-induced-by-palmitic-acid
#1
Xiao-Zhen Ma, Zheng-Da Pang, Jun-Hong Wang, Zheng Song, Li-Mei Zhao, Xiao-Jun Du, Xiu-Ling Deng
Monocyte migration into diseased tissues contributes to the pathogenesis of diseases. Intermediate-conductance Ca2+ -activated K+ (KCa 3.1) channels play an important role in cell migration. However, the role of KCa 3.1 channels in mediating monocyte migration induced by palmitic acid (PA) is still unclear. Using cultured THP-1 cells and peripheral blood mononuclear cells from healthy subjects, we investigated the role and signaling mechanisms of KCa 3.1 channels in mediating the migration induced by PA. Using methods of Western blotting analysis, RNA interference, cell migration assay and ELISA, we found that PA-treated monocytes exhibited increment of the protein levels of KCa 3...
May 21, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29757251/integral-sensor-fault-detection-and-isolation-for-railway-traction-drive
#2
Fernando Garramiola, Jon Del Olmo, Javier Poza, Patxi Madina, Gaizka Almandoz
Due to the increasing importance of reliability and availability of electric traction drives in Railway applications, early detection of faults has become an important key for Railway traction drive manufacturers. Sensor faults are important sources of failures. Among the different fault diagnosis approaches, in this article an integral diagnosis strategy for sensors in traction drives is presented. Such strategy is composed of an observer-based approach for direct current (DC)-link voltage and catenary current sensors, a frequency analysis approach for motor current phase sensors and a hardware redundancy solution for speed sensors...
May 13, 2018: Sensors
https://www.readbyqxmd.com/read/29755916/a-case-of-sinonasal-undifferentiated-carcinoma-with-brain-metastases
#3
Julianna Sienna, Nhu-Tram Nguyen, Julie Arsenault, Ian Hodson, Brandon Meyers
Sinonasal undifferentiated carcinoma (SNUC) is a rare aggressive neoplasm arising in the nasal cavity and paranasal sinuses. We report a unique case of an 80-year-old man who presented with a locally advanced SNUC involving the ethmoid, sphenoid, and maxillary sinuses and bilateral lymph nodes, clinical T4N2M0. Given his age and the initial extent of his primary tumour, he was treated with neoadjuvant chemotherapy followed by chemoradiation with a split course of 50 Gray (Gy) in 40 fractions delivered twice a day...
March 13, 2018: Curēus
https://www.readbyqxmd.com/read/29743027/quantification-of-fdg-pet-ct-with-delayed-imaging-in-patients-with-newly-diagnosed-recurrent-breast-cancer
#4
Christina Baun, Kirsten Falch, Oke Gerke, Jeanette Hansen, Tram Nguyen, Abass Alavi, Poul-Flemming Høilund-Carlsen, Malene G Hildebrandt
BACKGROUND: Several studies have shown the advantage of delayed-time-point imaging with 18F-FDG-PET/CT to distinguish malignant from benign uptake. This may be relevant in cancer diseases with low metabolism, such as breast cancer. We aimed at examining the change in SUV from 1 h (1h) to 3 h (3h) time-point imaging in local and distant lesions in patients with recurrent breast cancer. Furthermore, we investigated the effect of partial volume correction in the different types of metastases, using semi-automatic quantitative software (ROVER™)...
May 9, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29740474/integrated-quantitative-transcriptome-maps-of-human-trisomy-21-tissues-and-cells
#5
Maria Chiara Pelleri, Chiara Cattani, Lorenza Vitale, Francesca Antonaros, Pierluigi Strippoli, Chiara Locatelli, Guido Cocchi, Allison Piovesan, Maria Caracausi
Down syndrome (DS) is due to the presence of an extra full or partial chromosome 21 (Hsa21). The identification of genes contributing to DS pathogenesis could be the key to any rational therapy of the associated intellectual disability. We aim at generating quantitative transcriptome maps in DS integrating all gene expression profile datasets available for any cell type or tissue, to obtain a complete model of the transcriptome in terms of both expression values for each gene and segmental trend of gene expression along each chromosome...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29727218/activated-no-pathway-in-uterine-arteries-during-pregnancy-in-iugr-rat-model
#6
Emilie Bigonnesse, Benoit Sicotte, Michele Brochu
Insufficient development of the utero-placental circulation may contribute to the development of intrauterine growth restriction (IUGR). We developed a rat model of IUGR by administering a low-sodium diet. This diet reduces maternal blood volume expansion and uteroplacental perfusion. We hypothesized that an impaired endothelial function in radial arteries decreases vasorelaxation and lowers placental perfusion in this IUGR model. The objective was to assess radial uterine artery responses to vasoactive agents in the IUGR model, versus controls...
May 4, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29723734/characteristics-of-single-vehicle-crashes-with-e-bikes-in-switzerland
#7
Patrizia Hertach, Andrea Uhr, Steffen Niemann, Mario Cavegn
In Switzerland, the usage and accident numbers of e-bikes have strongly increased in recent years. According to official statistics, single-vehicle accidents constitute an important crash type. Up to date, very little is known about the mechanisms and causes of these crashes. To gain more insight, a survey was conducted among 3658 e-cyclists in 2016. The crash risk and injury severity were analysed using logistic regression models. 638 (17%) e-cyclists had experienced a single-vehicle accident in road traffic since the beginning of their e-bike use...
April 30, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29718895/long-term-outcomes-of-patients-with-breast-cancer-after-nipple-sparing-mastectomy-skin-sparing-mastectomy-followed-by-immediate-transverse-rectus-abdominis-musculocutaneous-flap-reconstruction-comparison-with-conventional-mastectomy-in-a-single-center-study
#8
Sae Byul Lee, Jong Won Lee, Hee Jeong Kim, Beom Seok Ko, Byung Ho Son, Jin Sup Eom, Taik Jong Lee, Sei-Hyun Ahn
To evaluate the oncological outcomes of patients with breast cancer after nipple-sparing mastectomy (NSM)/skin-sparing mastectomy (SSM), followed by immediate reconstruction, as compared to conventional mastectomy (CM).SSM/NSM has been increasingly used to treat women with breast cancer who wish to preserve the overlying breast skin, but concern exist regarding its oncological safety due to the potential for residual breast tissue. We report our experience performing SSM/NSM for breast cancer treatment compared to CM with a long follow-up period...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29716774/dengue-vaccination-during-pregnancy-an-overview-of-clinical-trials-data
#9
Anna Skipetrova, Tram Anh Wartel, Sophia Gailhardou
BACKGROUND: The live, attenuated, tetravalent dengue vaccine (CYD-TDV) is licensed in several endemic countries and contraindicated during pregnancy. Inadvertent vaccination during pregnancy may occur during clinical trials that include women of childbearing age. The potential risk associated with dengue vaccination in pregnancy remains unknown. We describe pregnancy outcomes following inadvertent dengue vaccination in pregnancy from CYD-TDV trial data. METHODS: Data were collected from trials conducted as part of the CYD-TDV clinical development...
April 28, 2018: Vaccine
https://www.readbyqxmd.com/read/29692805/potential-use-of-essential-oil-isolated-from-cleistocalyx-operculatus-leaves-as-a-topical-dermatological-agent-for-treatment-of-burn-wound
#10
Gia-Buu Tran, Nghia-Thu Tram Le, Sao-Mai Dam
Several herbal remedies have been used as topical agents to cure burn wound, one of the most common injuries in worldwide. In this study, we investigated the potential use of Cleistocalyx operculatus essential oil to treat the burn wound. We identified a total of 13 bioactive compounds of essential oil, several of which exhibited the anti-inflammatory and antimicrobial activities. Furthermore, the essential oil showed the antibacterial effect against S. aureus but not with P. aeruginosa. The supportive effect of essential oil on burn wound healing process also has been proven...
2018: Dermatology Research and Practice
https://www.readbyqxmd.com/read/29683935/re-clinical-and-qualitative-isokinetic-comparison-of-abdominal-morbidity-and-dynamics-following-diep-verses-muscle-sparing-free-tram-flap-breast-reconstruction
#11
Jonas A Nelson, Joseph J Disa
No abstract text is available yet for this article.
March 31, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29677710/volatile-and-nonvolatile-characteristics-of-asymmetric-dual-gate-thyristor-ram-with-vertical-structure
#12
Hyun-Min Kim, Dae Woong Kwon, Sihyun Kim, Kitae Lee, Junil Lee, Euyhwan Park, Ryoongbin Lee, Hyungjin Kim, Sangwan Kim, Byung-Gook Park
In this paper, the volatile and nonvolatile characteristics of asymmetric dual-gate thyristor random access memory (TRAM) are investigated using the technology of a computer-aided design (TCAD) simulation. Owing to the use of two independent gates having different gate dielectric layers, volatile and nonvolatile memory functions can be realized in a single device. The first gate with a silicon oxide layer controls the one-transistor dynamic random access memory (1T-DRAM) characteristics of the device. From the simulation results, a rapid write speed (<8 ns) and a large on-off current ratio (>107) can be achieved...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29672891/glecaprevir-pibrentasvir-treatment-in-liver-or-kidney-transplant-patients-with-hepatitis-c-virus-infection
#13
Nancy Reau, Paul Y Kwo, Susan Rhee, Robert S Brown, Kosh Agarwal, Peter Angus, Edward Gane, Jia-Horng Kao, Parvez S Mantry, David Mutimer, K Rajender Reddy, Tram T Tran, Yiran B Hu, Abhishek Gulati, Preethi Krishnan, Emily O Dumas, Ariel Porcalla, Nancy S Shulman, Wei Liu, Suvajit Samanta, Roger Trinh, Xavier Forns
Well-tolerated, ribavirin-free, pangenotypic hepatitis C virus (HCV) treatments for transplant recipients remain a high priority. Once-daily glecaprevir/pibrentasvir demonstrates high rates of sustained virologic response for 12 weeks post-treatment (SVR12) across all major HCV genotypes (GT). This trial evaluated the safety and efficacy of glecaprevir/pibrentasvir for patients with chronic HCV GT1-6 infection who had received a liver or kidney transplant. MAGELLAN-2 was a phase 3, open-label trial conducted in patients who were ≥3 months post-transplant...
April 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29659511/quorum-sensing-and-quorum-quenching-in-agrobacterium-a-go-no-go-system
#14
REVIEW
Yves Dessaux, Denis Faure
The pathogen Agrobacterium induces gall formation on a wide range of dicotyledonous plants. In this bacteria, most pathogenicity determinants are borne on the tumour inducing (Ti) plasmid. The conjugative transfer of this plasmid between agrobacteria is regulated by quorum sensing (QS). However, processes involved in the disturbance of QS also occur in this bacteria under the molecular form of a protein, TraM, inhibiting the sensing of the QS signals, and two lactonases BlcC (AttM) and AiiB that degrade the acylhomoserine lactone (AHL) QS signal...
April 16, 2018: Genes
https://www.readbyqxmd.com/read/29659449/evolution-in-monitoring-of-free-flap-autologous-breast-reconstruction-after-nipple-sparing-mastectomy-is-there-a-best-way
#15
Jordan D Frey, John T Stranix, Michael V Chiodo, Michael Alperovich, Christina Y Ahn, Robert J Allen, Mihye Choi, Nolan S Karp, Jamie P Levine
BACKGROUND: Free flap monitoring in autologous reconstruction after nipple-sparing mastectomy remains controversial. The authors therefore examined outcomes in nipple-sparing mastectomy with buried free flap reconstruction versus free flap reconstruction incorporating a monitoring skin paddle. METHODS: Autologous free flap reconstructions with nipple-sparing mastectomy performed from 2006 to 2015 were identified. Demographics and operative results were analyzed and compared between buried flaps and those with a skin paddle for monitoring...
May 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29658531/preliminary-assessment-of-vibration-impacts-generated-by-the-public-transport-systems-on-pregnant-women-based-on-subjective-reactions
#16
Magdalena Kromka-Szydek, Zygmunt Dziechciowski, Paulina Tyrpin
PURPOSE: Research efforts summarised in this study were a part of preliminary investigation to evaluate the impact of pregnant women's exposure to vibrations generated by public transport system when using. METHODS: The assessment of the problem and discomfort for pregnant women, caused by the public transportation is based on a questionnaire including questions relating to the women's subjective feelings on well-being or discomfort when exposed to vibration during the ride in passenger cars or when using means of public transport...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29655708/salivary-flow-rate-after-conventional-and-intensity-modulated-radiation-therapy
#17
Caroline Tram Nguyen, Spencer Lin, Haley Clark, Allan Hovan, Jonn Wu
BACKGROUND: Conventional 3-dimensional conformal radiation therapy (3DCRT) for head and neck cancer (HNC) can cause hyposalivation, leading to caries and tooth extraction-related osteoradionecrosis. Intensity-modulated radiation therapy (IMRT) delivers more focused radiation than does 3DCRT. To reduce hyposalivation, the Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) guidelines limit salivary gland radiation dose. In this study, the authors compared the salivary flow rate in patients receiving 3DCRT and those receiving IMRT and evaluated the effect of their treatment satisfying the QUANTEC guidelines on hyposalivation...
April 11, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29655569/activation-of-the-porcine-alveolar-macrophages-via-toll-like-receptor-4-nf-%C3%AE%C2%BAb-mediated-pathway-provides-a-mechanism-of-resistin-leading-to-inflammation
#18
Bi Li, Jing Fang, Zhicai Zuo, Sirui Yin, Tingting He, Mingxian Yang, Junliang Deng, Liuhong Shen, Xiaoping Ma, Shumin Yu, Ya Wang, Zhihua Ren, Hengmin Cui
Resistin, a previously discovered cysteine-rich adipokine known to regulate glucose metabolism, has been emerged as a mediator in inflammation and immunity. Its level was supposed to be related to the expression of indicators, such as interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) in inflammation. Toll-like receptor 4 (TLR4) was reported to be a receptor for resistin in cells, like leukocytes and peripheral blood mononuclear cells (PBMC). However, the pro-inflammatory role of resistin and its intracellular mechanisms in alveolar macrophages have not been thoroughly validated...
April 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29621746/crocin-improves-the-endothelial-function-regulated-by-kca3-1-through-erk-and-akt-signaling-pathways
#19
Huike Yang, Xuemei Li, Yang Liu, Xinlei Li, Xiaodong Li, Mengnan Wu, Xiaohong Lv, Chun Chunhua, Xuansheng Ding, Yafang Zhang
BACKGROUND/AIMS: Based on the protective effect of crocin against cardiovascular diseases, we hypothesize that crocin could improve endothelial function through activating the eNOS(endothelial nitric oxide synthase) /NO pathway and/or the intermediate-conductance Ca2+-activated K+ channels (KCa3.1). METHODS: In this study, rat aortic rings were used to assess the regulatory effect of crocin on vascular tone and nitric oxide, prostacyclin, and KCa3.1, all endothelial vasodilators, were analyzed for effects by crocin...
March 29, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29588171/mechanism-of-adrenomedullin-2-intermedin-mediated-vasorelaxation-in-rat-main-pulmonary-artery
#20
Gokcen Telli, Yasemin Erac, Banu Cahide Tel, Bulent Gumusel
Adrenomedullin 2/intermedin (AM2/IMD) is a member of calcitonin related gene peptide family and an important nitric oxide mediated vasorelaxant in various vascular beds. However, the mechanism of post receptor-interaction is not clear and may differ depending on tissue type and species. In this study, we aimed to investigate the exact mechanism and the role of BKCa and calcium channels on the vasorelaxant effect of AM2/IMD in rat PA. Changes in the AM2/IMD-mediated vasorelaxation were evaluated in the presence of various inhibitors...
March 24, 2018: Peptides
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