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https://www.readbyqxmd.com/read/29331919/removal-of-pharmaceutical-pollutants-from-synthetic-wastewater-using-chemically-modified-biomass-of-green-alga-scenedesmus-obliquus
#1
Mohamed E M Ali, Azza M Abd El-Aty, Mohamed I Badawy, Rizka K Ali
Pharmaceutical compounds are considered emerging environmental pollutants that have a potential harmful impact on environment and human health. In this study, the biomass of alga (Scenedesmus obliquus) was modified using alkaline solution, and used for the biosorption of tramadol (TRAM) and other pharmaceuticals. The adsorption kinetics and isotherms were investigated. The obtained results reveal high adsorption capacity of tramadol over modified algal biomass (MAB) after 45min with removal percentage of 91%...
January 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29330011/mutations-in-pi3k110%C3%AE-cause-impaired-nk-cell-function-partially-rescued-by-rapamycin-treatment
#2
Raquel Ruiz-García, Alexander Vargas-Hernandez, Ivan K Chinn, Laura S Angelo, Tram N Cao, Zeynep Coban-Akdemir, Shalini N Jhangiani, Qingchang Meng, Lisa R Forbes, Donna M Muzny, Luis M Allende, Mohammed S Ehlayel, Richard A Gibbs, James R Lupski, Gulbu Uzel, Jordan S Orange, Emily M Mace
BACKGROUND: Heterozygous gain-of-function mutations in PI3K110 lead to lymphadenopathy, lymphoid hyperplasia, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) viremia, and sinopulmonary infections. OBJECTIVE: The known role of NK cell function in the control of EBV and CMV prompted us to investigate the functional and phenotypic effect of PI3K110δ mutations on NK cell subsets and cytotoxic function. METHODS: Patient mutations were identified by whole exome or targeted sequencing...
January 9, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29322432/renal-histopathological-findings-of-retinal-vasculopathy-with-cerebral-leukodystrophy
#3
Yutaka Tsubata, Takashi Morita, Tetsuo Morioka, Taiji Sasagawa, Kouzo Ikarashi, Noriko Saito, Hisaki Shimada, Shigeru Miyazaki, Shinji Sakai, Hajime Tanaka, Rie Saito, Yasuko Toyoshima, Hiroaki Nozaki, Ichiei Narita
Retinal vasculopathy with cerebral leukodystrophy (RVCL) is a rare autosomal dominant systemic microvascular disease. Neurological disorders and visual disturbance are highlighted as manifestations of RVCL; however, there are few reports focused on nephropathy. Herein, we describe detailed renal histopathological findings in a daughter and father with RVCL, proven by TREX1 genetic analysis. A kidney biopsy of the daughter, 35-year-old with asymptomatic proteinuria, revealed unique and various glomerular changes...
January 10, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29302714/development-of-a-procedure-for-evaluating-the-impacts-of-the-accidental-emission-of-hazardous-chemicals-case-study-in-ho-chi-minh-city-vietnam
#4
Do Thi Thu Huyen, Ly Thi Bich Tram
The study aims at developing a process to evaluate the impacts of the accidental emission of hazardous chemicals. The proposed process consists of four basic steps: i) identifying risks/hazards; ii) development of the worst-case scenario; iii) simulating the emission and dispersion of the toxic chemicals; and iv) assessing the severity of the impact to the people and the surroundings. It makes use of different techniques including accidental release source term, atmospheric dispersion modeling and results in the concentration and extent of the toxic chemicals in the atmosphere for either the direct evaporation of toxic chemicals as a primary emission or the dispersion of toxic chemicals as a domino effect of a fire or explosion accident...
January 4, 2018: Environmental Management
https://www.readbyqxmd.com/read/29301197/a-novel-segment-based-approach-for-improving-classification-performance-of-transport-mode-detection
#5
M Amac Guvensan, Burak Dusun, Baris Can, H Irem Turkmen
Transportation planning and solutions have an enormous impact on city life. To minimize the transport duration, urban planners should understand and elaborate the mobility of a city. Thus, researchers look toward monitoring people's daily activities including transportation types and duration by taking advantage of individual's smartphones. This paper introduces a novel segment-based transport mode detection architecture in order to improve the results of traditional classification algorithms in the literature...
December 30, 2017: Sensors
https://www.readbyqxmd.com/read/29299881/-xe-international-congress-of-the-soci%C3%A3-t%C3%A3-de-pathologie-exotique-8-9-november-2017-haiphong-vietnam-surgery-access-in-tropical-areas
#6
Y Buisson, P Guyon, Y Buisson, N Osinki, C Tamames, J Leconte, M Jarry, J Robert, C Dumurgier, O Choua, M O Ahmat, K M Moussa, D Sabe, A Telniaret, A M Rabo, N Kitoko, B Allatombaye, Duong Bunn, Nguyen Hong Dao, Le Duc Huy, Hoang Le Bich Ngoc, Le Hong Tram, Tran Van Khoi, Pham Van Thuc, Pham Van Linh, K Kourouma, F T Gerald, K Kourouma, P O Saibou, G C Ngunyi, B Wombe, P Alessandroni, R Andrei, J Delmont, C Gasiglia, V V Haï, M Heng, T Heng, C Khampho, D Mekhalfa, S Marcaggi, M Pimontipa, J-R Plotton, N A The Ngo, T Vilayphone, Tran Xuan Duong, Nguyen Lam Hoa, J-F Pays, P Buchy, C Goujon, O Bouchaud, P-H Consigny, L de Gentile, E D'Ortenzio, Ph Gautret, F Sorge, C Strady, E Pichard, C Haddar, E Bégaud, Mook Yun Yuh, Eng Lim Law, Y Germani, O Bouchaud, S Houze, J Chandenier, J Jannin, P Solano, I Quick, P Debre, P Guyon, A Ensaf, P Bourée, B Fabre-Teste, M El Mouden, G Soula
No abstract text is available yet for this article.
December 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/29291251/gaps-in-the-child-tuberculosis-care-cascade-in-32-rural-communities-in-uganda-and-kenya
#7
Florence Mwangwa, Gabriel Chamie, Dalsone Kwarisiima, James Ayieko, Asiphas Owaraganise, Theodore D Ruel, Albert Plenty, Khai Hoan Tram, Tamara D Clark, Craig R Cohen, Elizabeth A Bukusi, Maya Petersen, Moses R Kamya, Edwin D Charlebois, Diane V Havlir, Carina Marquez
Background: Reducing tuberculosis (TB) deaths among children requires a better understanding of the gaps in the care cascade from TB diagnosis to treatment completion. We sought to assess the child TB care cascade in 32 rural communities in Uganda and Kenya using programmatic data. Methods: This is a retrospective cohort study of 160,851 children (ages <15 years) living in 12 rural communities in Kenya and 22 in Uganda. We reviewed national TB registries from health centers in and adjacent to the 32 communities, and we included all child TB cases recorded from January 1, 2013 to June 30, 2016...
December 2017: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
https://www.readbyqxmd.com/read/29278444/%C3%AE-adrenergic-receptor-blocker-ici-118-551-selectively-increases-intermediate-conductance-calcium-activated-potassium-channel-ikca-mediated-relaxations-in-rat-main-mesenteric-artery
#8
Melike Hacer Ozkan, Serdar Uma
Endothelial IKCa and/or SKCa channels play an important role in the control of vascular tone by participating in endothelium-dependent relaxation. Whether β-AR antagonists, mainly used in hypertension, affect endothelial KCa channel function is unknown. In this study, we examined the effect of the β2-AR antagonist and inverse agonist ICI 118,551 on the IKCa /SKCa channel activity by assessing functional relaxation responses to several agonists that stimulate these channels. Mesenteric arterial rings isolated from male Spraque-Dawley mounted to organ baths...
December 26, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29259557/red-blood-cell-passage-of-small-capillaries-is-associated-with-transient-ca2-mediated-adaptations
#9
Jens G Danielczok, Emmanuel Terriac, Laura Hertz, Polina Petkova-Kirova, Franziska Lautenschläger, Matthias W Laschke, Lars Kaestner
When red blood cells (RBCs) pass constrictions or small capillaries they need to pass apertures falling well below their own cross section size. We used different means of mechanical stimulations (hypoosmotic swelling, local mechanical stimulation, passing through microfluidic constrictions) to observe cellular responses of human RBCs in terms of intracellular Ca2+-signaling by confocal microscopy of Fluo-4 loaded RBCs. We were able to confirm our in vitro results in a mouse dorsal skinfold chamber model showing a transiently increased intracellular Ca2+ when RBCs were passing through small capillaries in vivo...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29248421/m%C3%A3-nckeberg-medial-calcinosis-of-the-infraorbital-arteries-a-first-case-report
#10
John J Frazier, Regina Casian, Byron W Benson
Mönckeberg medial calcinosis describes calcifications affecting only the tunica media of medium-sized arteries. The entity is strongly associated with chronic kidney disease and diabetes mellitus. Radiographically, medial calcinosis presents as areas of linear calcifications in soft tissue; the linear calcifications are referred to as "tram tracks," "pipe stem," "rail tracking," or "tram line" when the affected vessel is viewed longitudinally. In oral and maxillofacial radiology, it is generally an incidental finding of the facial artery...
November 22, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29246953/ca2-dependent-regulation-of-nfatc1-via-kca3-1-in-inflammatory-osteoclastogenesis
#11
Eva M Grössinger, Mincheol Kang, Laura Bouchareychas, Ritu Sarin, Dominik R Haudenschild, Laura N Borodinsky, Iannis E Adamopoulos
In inflammatory arthritis, the dysregulation of osteoclast activity by proinflammatory cytokines, including TNF, interferes with bone remodeling during inflammation through Ca2+-dependent mechanisms causing pathological bone loss. Ca2+-dependent CREB/c-fos activation via Ca2+-calmodulin kinase IV (CaMKIV) induces transcriptional regulation of osteoclast-specific genes via NFATc1, which facilitate bone resorption. In leukocytes, Ca2+ regulation of NFAT-dependent gene expression oftentimes involves the activity of the Ca2+-activated K+ channel KCa3...
December 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29244735/development-of-the-precision-link-biobank-at-boston-children-s-hospital-challenges-and-opportunities
#12
REVIEW
Florence T Bourgeois, Paul Avillach, Sek Won Kong, Michelle M Heinz, Tram A Tran, Ramkrishna Chakrabarty, Jonathan Bickel, Piotr Sliz, Erin M Borglund, Susan Kornetsky, Kenneth D Mandl
Increasingly, biobanks are being developed to support organized collections of biological specimens and associated clinical information on broadly consented, diverse patient populations. We describe the implementation of a pediatric biobank, comprised of a fully-informed patient cohort linking specimens to phenotypic data derived from electronic health records (EHR). The Biobank was launched after multiple stakeholders' input and implemented initially in a pilot phase before hospital-wide expansion in 2016...
December 15, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29229731/activation-of-porcine-alveolar-macrophages-by-actinobacillus-pleuropneumoniae-lipopolysaccharide-via-the-tlr4-nf-%C3%AE%C2%BAb-mediated-pathway
#13
Bi Li, Jing Fang, Zhicai Zuo, Sirui Yin, Tingting He, Mingxian Yang, Junliang Deng, Liuhong Shen, Xiaoping Ma, Shumin Yu, Ya Wang, Zhihua Ren
Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is a causative agent of the porcine contagious pleuropneumonia. Overproduction of pro-inflammatory cytokines like IL-1β, IL-6, TNF-α and Resistin in lung is an important feature of A. pleuropneumoniae infection. These pro-inflammatory cytokines enhance inflammatory and immunological responses. However, the mechanism that leads to cytokines production remains unclear. As a major virulent factor of A. pleuropneumoniae, lipopolysaccharide (LPS) may act as a potent stimulator of TLR4, triggering a number of intracellular signaling pathways that lead to synthesis of pro-inflammatory cytokines...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29227815/meta-analysis-of-flap-perfusion-and-donor-site-complications-for-breast-reconstruction-using-pedicled-versus-free-tram-and-diep-flaps
#14
REVIEW
Woonhyeok Jeong, Seongwon Lee, Junhyung Kim
OBJECTIVES: The transverse rectus abdominis musculocutaneous (TRAM) flap is an important option for breast reconstruction. Several studies have recently evaluated whether a greater number of complications result from the use of pedicled TRAM (pTRAM) flaps versus either free TRAM (fTRAM) flaps or deep inferior epigastric artery perforator (DIEP) flaps. To clarify the evidence regarding this issue, we performed an objective meta-analysis of published studies. MATERIALS AND METHODS: A literature search of articles published between January 1, 1990, to January 1, 2017 was performed using the PubMed, EMBASE, Scopus, and Cochrane databases...
December 8, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29209302/influence-of-stress-and-antibiotic-resistance-on-cell-length-distribution-in-mycobacterium-tuberculosis-clinical-isolates
#15
Srinivasan Vijay, Dao N Vinh, Hoang T Hai, Vu T N Ha, Vu T M Dung, Tran D Dinh, Hoang N Nhung, Trinh T B Tram, Bree B Aldridge, Nguyen T Hanh, Do D A Thu, Nguyen H Phu, Guy E Thwaites, Nguyen T T Thuong
Mycobacterial cellular variations in growth and division increase heterogeneity in cell length, possibly contributing to cell-to-cell variation in host and antibiotic stress tolerance. This may be one of the factors influencing Mycobacterium tuberculosis persistence to antibiotics. Tuberculosis (TB) is a major public health problem in developing countries, antibiotic persistence, and emergence of antibiotic resistance further complicates this problem. We wanted to investigate the factors influencing cell-length distribution in clinical M...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29202331/using-the-icf-in-transition-research-and-practice-lessons-from-a-scoping-review
#16
REVIEW
Tram Nguyen, Debra Stewart, Peter Rosenbaum, Sue Baptiste, Olaf Kraus de Camargo, Jan Willem Gorter
BACKGROUND: The International Classification of Functioning, Disability and Health (ICF) and subsequent ICF-CY (child and youth version) recognize the importance of personal and environmental factors in facilitating holistic transition planning and service delivery for youth with chronic health conditions (YCHC). AIMS: The objective of this scoping review is to investigate the degree to which the ICF and ICF-CY have been used in transition research and practice since its initial publication...
January 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29197543/role-of-dopamine-d1-receptor-in-3-fluoromethamphetamine-induced-neurotoxicity-in-mice
#17
Phuong-Tram Nguyen, Eun-Joo Shin, Duy-Khanh Dang, Hai-Quyen Tran, Choon-Gon Jang, Ji Hoon Jeong, Yu Jeung Lee, Hyo Jong Lee, Yong Sup Lee, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Kim
3-Fluoromethamphetamine (3-FMA) is an illegal designer drug of methamphetamine (MA) derivative. Up to date, little is known about the neurotoxic potential of 3-FMA. In the present study, we investigated the role of dopamine receptors in neurotoxicity induced by 3-FMA in comparison with MA (35 mg/kg, i.p.) as a control drug. Here we found that 3-FMA (40, 60 or 80 mg/kg, i.p.) produced mortality in a dose-dependent manner in mice. Treatment with 3-FMA (40 mg/kg, i.p.) resulted in significant hyperthermia, oxidative stress and microgliosis (microglial differentiation into M1 phenotype) followed by pro-apoptotic changes and the induction of terminal deoxynucleotidyl transferase dUDP nick end labeling (TUNEL)-positive cells...
November 29, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29185556/online-tools-for-individuals-with-depression-and-neurologic-conditions-a-scoping-review
#18
REVIEW
Sara Lukmanji, Tram Pham, Laura Blaikie, Callie Clark, Nathalie Jetté, Samuel Wiebe, Andrew Bulloch, Jayna Holroyd-Leduc, Sophia Macrodimitris, Aaron Mackie, Scott B Patten
Background: Patients with neurologic conditions commonly have depression. Online tools have the potential to improve outcomes in these patients in an efficient and accessible manner. We aimed to identify evidence-informed online tools for patients with comorbid neurologic conditions and depression. Methods: A scoping review of online tools (free, publicly available, and not requiring a facilitator) for patients with depression and epilepsy, Parkinson disease (PD), multiple sclerosis (MS), traumatic brain injury (TBI), or migraine was conducted...
August 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29174207/detection-of-the-tram-track-lesion-in-the-ankle-joint-comparing-3-0-tesla-magnetic-resonance-imaging-and-arthroscopy
#19
Dong Woo Shim, Sungjun Kim, Yeokgu Hwang, Yunjae Lee, Jin Woo Lee, Seung Hwan Han
PURPOSE: To show the effectiveness of magnetic resonance imaging (MRI) for the detection of tram track lesions in the ankle compared with ankle arthroscopy. METHODS: We retrospectively assessed all patients who underwent arthroscopic ankle surgery between January 2013 and July 2015. Patients with anterior impingement spurs were included, but those with an osteochondral lesion or arthritis were excluded. Anterior ankle bony spurs on preoperative weight-bearing radiographs were scored using an impingement classification system...
November 21, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29155708/enrichment-of-detergent-insoluble-protein-aggregates-from-human-postmortem-brain
#20
Ian Diner, Tram Nguyen, Nicholas T Seyfried
In this study, we describe an abbreviated single-step fractionation protocol for the enrichment of detergent-insoluble protein aggregates from human postmortem brain. The ionic detergent N-lauryl-sarcosine (sarkosyl) effectively solubilizes natively folded proteins in brain tissue allowing the enrichment of detergent-insoluble protein aggregates from a wide range of neurodegenerative proteinopathies, such as Alzheimer's disease (AD), Parkinson's disease and amyotrophic lateral sclerosis, and prion diseases...
October 24, 2017: Journal of Visualized Experiments: JoVE
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