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https://www.readbyqxmd.com/read/28719300/chikungunya-and-zika-virus-cases-detected-against-a-backdrop-of-endemic-dengue-transmission-in-vietnam
#1
Nguyen Than Ha Quyen, Duong Thi Hue Kien, Maia Rabaa, Nguyen Minh Tuan, Tran Thuy Vi, Le Van Tan, Nguyen Thanh Hung, Ha Manh Tuan, Ta Van Tram, Nguyen Le Da Ha, Han Khoi Quang, Nguyen Quoc Doanh, Nguyen Van Vinh Chau, Bridget Wills, Cameron P Simmons
Between 2010 and 2014, four chikungunya and two Zika virus infections were identified among 8,105 febrile children in southern Vietnam. Zika viruses were linked to French Polynesian strains, chikungunya to Cambodian strains. Against a backdrop of endemic dengue transmission, chikungunya and Zika present an additional arboviral disease burden in Vietnam.
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28713703/comparative-perfusion-analysis-of-free-muscle-sparing-versus-pedicle-transverse-rectus-abdominis-myocutaneous-tram-flaps-in-vivo-in-the-peri-operative-and-late-post-operative-periods
#2
Richard McNally, Jonathan Rimler, Vincent Laurence, Keyianoosh Z Paydar, Garrett A Wirth
BACKGROUND: Current teaching suggests increased perfusion in free transverse rectus abdominis myocutaneous (TRAM) flaps over pedicled TRAM flaps, broadening indications for its use in high risk patients. This study compared perfusion analysis of free muscle-sparing versus pedicle TRAM flaps in vivo in the peri-operative and late post-operative periods. METHODS: The SPY-Elite system using indocyanine green dye was used to analyze flap perfusion intra-operatively and at 1 week and 3 months post-operatively...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28705620/application-of-continuous-twin-screw-granulation-for-the-metformin-hydrochloride-extended-release-formulation
#3
Su-Hyeon Kim, Kyu-Min Hwang, Cheol-Hee Cho, Thi-Tram Nguyen, Su Hyun Seok, Kyu-Mok Hwang, Ju-Young Kim, Chun-Woong Park, Yun-Seok Rhee, Eun-Seok Park
This study focuses on evaluating the potential of transferring from a batch process to continuous process for manufacturing of the extended release formulation. Metformin hydrochloride (HCl) was used in the model formulation which was intended to contain the high amount of hydrophilic drug. The effects of barrel temperature, binder type, powder feed rate, and screw speed on granule properties (size and strength) and torque value in twin screw granulation were investigated. Due to the high content of hydrophilic model drug, the granules prepared at a higher temperature with HPMC binding solution had the narrower size distribution and greater strength than the granules prepared with distilled water as a binding solution...
July 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28697187/can-semiquantitative-measurements-of-suvmax-and-cut-off-values-differentiate-malignant-from-benign-colorectal-cancer
#4
Tram Nguyen, Søren Hess, Henrik Petersen, Abass Alavi, Poul Flemming Høilund-Carlsen
OBJECTIVE: We investigated maximum standardized uptake value (SUVmax) and cut-off values for differentiation of malignant and benign lesions in colorectal cancer (CC) as multiple studies have questioned their validity. We also investigated more extended indices using common semi-quantification analysis in incidental colorectal findings (ICF). SUBJECTS AND METHODS: Fluorine-18-fluoro deoxy glucose positron emission tomography/computed tomography in 25 patients with a total of 30 focal ICF was retrospectively analysed using dedicated software...
July 12, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28688657/umbilical-necrosis-rates-after-abdominal-based-microsurgical-breast-reconstruction
#5
Joseph A Ricci, Parisa Kamali, Babette E Becherer, Daniel Curiel, Winona Wu, Adam M Tobias, Samuel J Lin, Bernard T Lee
BACKGROUND: Umbilical stalk necrosis represents a rare, yet important complication after abdominal-based microsurgical breast reconstruction, which is both underrecognized and understudied in the literature. Once identified, umbilical reconstruction can be an extremely challenging problem. METHODS: All consecutive breast free flaps at a single institution from February 2004 to February 2016 were reviewed, excluding non-abdominal-based flaps. Patients were divided based on the development of umbilical necrosis postoperatively...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28682914/multiple-pedicled-flaps-cover-for-large-defects-following-resection-of-malignant-tumors-with-partition-concept
#6
Chenyang Ji, Ruiting Li, Grace Shen, Jinming Zhang, Weiqiang Liang
Large defects after skin malignant tumors resection were difficult to repair. We introduced a partition concept, in which the large defects were divided into several subunits, and each subunit was repaired by a certain pedicled flap to achieve a complete coverage.Between May 2012 and Oct 2016, 8 patients with skin malignant tumors underwent radical resection. Prior to surgery, the dimension of the potential defect after tumor ablation was estimated and outlined. After evaluation, the partition concept was applied and the defects were divided into several subunits...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28679649/involvement-of-ca-2-activated-k-channel-3-1-in-hypoxia-induced-pulmonary-arterial-hypertension-and-therapeutic-effects-of-tram-34-in-rats
#7
Shujin Guo, Yongchun Shen, Guangming He, Tao Wang, Dan Xu, Fuqiang Wen
Pulmonary artery hypertension is an incurable disease associated with proliferation of pulmonary artery smooth cells (PASMCs) and vascular remodeling. This study examined whether TRAM-34, a highly selective blocker of calcium-activated potassium channel 3.1 (Kca3.1), can help prevent such hypertension by reducing proliferation of PASMCs. Rats were exposed to hypoxia (10% O2) for 3 weeks and treated daily with TRAM-34 intra-peritoneally from the first day of hypoxia. Animals were sacrificed and examined for vascular hypertrophy, Kca3...
July 5, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28677631/macromolecular-conjugate-and-biological-carrier-approaches-for-the-targeted-delivery-of-antibiotics
#8
REVIEW
Nhan Dai Thien Tram, Pui Lai Rachel Ee
For the past few decades, the rapid rise of antibiotic multidrug-resistance has presented a palpable threat to human health worldwide. Meanwhile, the number of novel antibiotics released to the market has been steadily declining. Therefore, it is imperative that we utilize innovative approaches for the development of antimicrobial therapies. This article will explore alternative strategies, namely drug conjugates and biological carriers for the targeted delivery of antibiotics, which are often eclipsed by their nanomedicine-based counterparts...
July 4, 2017: Antibiotics
https://www.readbyqxmd.com/read/28676010/kca3-1-channel-modulators-as-potential-therapeutic-compounds-for-glioblastoma
#9
Brandon M Brown, Brandon Pressley, Heike Wulff
The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is widely expressed in cells of the immune system such as T- and B-lymphocytes, mast cells, macrophages and microglia, but also found in dedifferentiated vascular smooth muscle cells, fibroblasts and many cancer cells including pancreatic, prostate, leukemia and glioblastoma. In all these cell types KCa3.1 plays an important role in cellular activation, migration and proliferation by regulating membrane potential and Ca2+ signaling. KCa3.1 therefore constitutes an attractive therapeutic target for diseases involving excessive proliferation or activation of one more of these cell types and researchers both in academia and in the pharmaceutical industry have developed several potent and selective small molecule inhibitors of KCa3...
June 30, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28673764/how-to-assess-sensory-recovery-after-breast-reconstruction-surgery
#10
Helena K Puonti, Taina A Broth, Seppo O Soinila, Helena K Hallikainen, Satu K Jääskeläinen
BACKGROUND: We evaluated clinical against psychophysical (tactile and thermal quantitative sensory test [QST]), neurophysiologic (somatosensory evoked potential [SEP]), and epithelial nerve fiber density (ENFD) examinations in detection and follow-up of sensory alterations after breast reconstruction done with or without nerve anastomoses. PATIENTS AND METHODS: In a prospective 2-year follow-up design, 56 breast cancer patients underwent innervated and 20 patients noninnervated free rectus abdominis muscle-sparing flap (ms-TRAM) breast reconstruction...
April 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28666390/exploiting-femtoliter-microwells-for-the-sensitive-measurement-of-protein-adsorption
#11
Gary M Nishioka, Reka Geczy, Kimberly S Huggler, Tram N Dao, Charles W Sokolik
A method is described for the sensitive measurement of adsorbed proteins using femtoliter microwells. Quantitative measurement of adsorbed protein is demonstrated at surface densities from 10 fg/cm(2) to 3 pg/cm(2). Determination of the efficacy of barrier coatings is also demonstrated using femtoliter microwells. Adsorption at low surface densities is measured, indicating the highest affinity sites on the surface and therefore the initial stages of adsorption. The femtoliter microwell method is shown to be useful in detecting differences between effective protective coatings...
July 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28660740/prolonged-first-line-peg-asparaginase-treatment-in-pediatric-acute-lymphoblastic-leukemia-in-the-nopho-all2008-protocol-pharmacokinetics-and-antibody-formation
#12
Louise Tram Henriksen, Sofie Gottschalk Højfeldt, Kjeld Schmiegelow, Thomas Leth Frandsen, Peder Skov Wehner, Henrik Schrøder, Birgitte Klug Albertsen
BACKGROUND: As pegylated asparaginase is becoming the preferred first-line asparaginase preparation in the chemotherapy regimens of childhood acute lymphoblastic leukemia (ALL), there is a need to evaluate this treatment. METHODS: The aim of this study was to evaluate the pharmacokinetics of prolonged upfront biweekly PEG-asparaginase (where PEG is polyethylene glycol) treatment by measuring serum l-asparaginase activity and formation of anti-PEG-asparaginase antibodies...
June 29, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28660401/individual-bayesian-information-matrix-for-predicting-estimation-error-and-shrinkage-of-individual-parameters-accounting-for-data-below-the-limit-of-quantification
#13
Thi Huyen Tram Nguyen, Thu Thuy Nguyen, France Mentré
PURPOSE: In mixed models, the relative standard errors (RSE) and shrinkage of individual parameters can be predicted from the individual Bayesian information matrix (MBF). We proposed an approach accounting for data below the limit of quantification (LOQ) in MBF. METHODS: MBF is the sum of the expectation of the individual Fisher information (MIF) which can be evaluated by First-Order linearization and the inverse of random effect variance. We expressed the individual information as a weighted sum of predicted MIF for every possible design composing of measurements above and/or below LOQ...
June 28, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28630139/functional-interfaces-between-ticam-2-tram-and-ticam-1-trif-in-tlr4-signaling
#14
REVIEW
Kenji Funami, Misako Matsumoto, Hiroyuki Oshiumi, Fuyuhiko Inagaki, Tsukasa Seya
Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS), produces pro-inflammatory cytokines and type I interferons, and associates with a trigger of endotoxin shock. TLR4 is interacted with a TIR domain-containing adaptor molecule-2 (TICAM-2)/TRAM [TRIF (TIR domain-containing adaptor-inducing interferon-β)-related adaptor molecule] via its Toll-interleukin-1 receptor homology (TIR) domain. TICAM-2 acts as a scaffold protein and activates TIR domain-containing adaptor molecule-1 (TICAM-1)/TRIF. According to the structural analysis by NMR, TICAM-2 interacts with TICAM-1 by the acidic amino acids motif, E87/D88/D89...
June 19, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28618735/three-layer-primary-closure-of-the-bipedicled-tram-flap-donor-site-for-unilateralbreast-reconstruction-a-15-year-experience-with-124-consecutive-patients
#15
Hüseyin Karagöz, Cihan Şahin, Celalettin Sever, Yalçın Külahçi, Fikret Eren, Ceyhun Cesur, Fuat Yüksel
BACKGROUND/AIM: The pedicled transverse rectus abdominis myocutaneous (TRAM) flap remains widely used as a breast reconstruction technique. The bipedicled TRAM flap is not as preferable as it was formerly, mainly because of its donor site complications. However, in a number of situations, a bipedicled TRAM flap may be the only alternative. Therefore, a three-layer primary closure technique used with bipedicled TRAM flap breast reconstructions that can avoid donor site complications without using a mesh is presented...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28615830/pedicled-transverse-rectus-abdominis-myocutaneous-flap-a-method-for-tunnelling-with-dilson-luz-vascular-dilation-wands-for-breast-reconstruction
#16
Christopher Tam Song, Joshua Perrett, Terence Goh, Bien Keem Tan
No abstract text is available yet for this article.
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28603785/patterns-of-gall-bladder-wall-thickening-in-dengue-fever-a-mirror-of-the-severity-of-disease
#17
Jitendra Premjibhai Parmar, Chander Mohan, Maulik Vora
BACKGROUND: Dengue fever is a major public health problem with an increased incidence in recent years. Gall bladder wall thickening has been reported as one of the most common findings in dengue fever. There is a paucity of literature regarding the various patterns of gall bladder wall thickening in dengue fever and their significance in predicting the severity of disease. METHODOLOGY AND SIGNIFICANT FINDINGS: Out of 93 seropositive patients included in the study, 54 patients with dengue fever had gall bladder wall thickening...
April 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/28602267/post-reconstruction-dermatitis-of-the-breast
#18
A C Rosen, C Goh, M E Lacouture, B J Mehrara, P G Cordeiro, P L Myskowski
BACKGROUND: Approximately one-third of women diagnosed with breast cancer undergo mastectomy with subsequent implant-based or autogenous tissue-based reconstruction. Potential complications include infection, capsular contracture, and leak or rupture of implants with necessity for explantation. Skin rashes are infrequently described complications of patients who undergo mastectomy with or without reconstruction. METHODS: A retrospective analysis of breast cancer patients referred to the Dermatology Service for diagnosis and management of a rash post-mastectomy and expander or implant placement or transverse rectus abdominis myocutaneous (TRAM) flap reconstruction was performed...
May 20, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28597927/the-prevalence-of-anxiety-and-associated-factors-in-persons-with-epilepsy
#19
Tram Pham, Khara M Sauro, Scott B Patten, Samuel Wiebe, Kirsten M Fiest, Andrew G M Bulloch, Nathalie Jetté
The objectives of this study were to estimate the prevalence of, and factors associated with, anxiety in epilepsy. We conducted a cross-sectional analysis using data from the Neurological Disease and Depression Study. The prevalence of anxiety and associated factors were assessed using descriptive statistics and logistic regression. Of the total sample (n = 250 patients), nearly 40.0% of participants had anxiety according to the Hospital Anxiety and Depression Scale. The most prevalent symptom of anxiety was "worrying thoughts" (35...
June 9, 2017: Epilepsia
https://www.readbyqxmd.com/read/28596600/detection-of-dna-amplicons-of-polymerase-chain-reaction-using-litmus-test
#20
Dingran Chang, Kha Tram, Ben Li, Qian Feng, Zhifa Shen, Christine H Lee, Bruno J Salena, Yingfu Li
We report on a new colorimetric DNA detection method that takes advantage of the power of polymerase chain reaction (PCR) and the simplicity of the classic litmus test. The strategy makes use of a modified set of primers for PCR to facilitate ensuing manipulations of resultant DNA amplicons: their tagging with urease and immobilization onto magnetic beads. The amplicon/urease-laden beads are then used to hydrolyze urea, resulting in the increase of pH that can be conveniently reported by a pH-sensitive dye...
June 8, 2017: Scientific Reports
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