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https://www.readbyqxmd.com/read/28217548/polygonum-multiflorum-root-extract-as-a-potential-candidate-for-treatment-of-early-graying-hair
#1
Nguyen Dinh Thang, Pham Ngoc Diep, Pham Thi Huong Lien, Le Thi Lien
Despite Polygonum multiflorum (PM) has been experiencely used as a drug to treat early graying hair phenomenon in Asian countries for a long time, there is limited study examined the real biological effects of PM on hair graying in vitro and in vivo. In this study, we investigated the effects of PM root extract (PM-RE) on melanin synthesis in human melanoma SKMEL-28 cells and embryos/larvae of wild-type strain AB zebrafish. We also preliminary revealed the molecular mechanism of early hair graying phenomenon in both in vitro and in vivo models...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28203495/correction-of-polymastia-vera-class-i-with-skin-sparing-mastectomy-and-immediate-rib-sparing-diep-flap-reconstruction
#2
Dominik Duscher, David Kiesl, Matthias Aitzetmüller, Manfred Schmidt, Georg M Huemer
No abstract text is available yet for this article.
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28195672/predictors-of-satisfaction-and-quality-of-life-following-post-mastectomy-breast-reconstruction
#3
Hannah Matthews, Natalie Carroll, Derek Renshaw, Andrew Turner, Alan Park, Jo Skillman, Kate McCarthy, Elizabeth A Grunfeld
OBJECTIVE: Breast reconstruction is associated with multiple psychological benefits. However, few studies have identified clinical and psychological factors associated with improved satisfaction and quality of life. This study examined factors which predict satisfaction with breast appearance, outcome satisfaction and quality of life following post-mastectomy breast reconstruction. METHODS: Women who underwent post-mastectomy breast reconstruction between 2010 and 2016 received a postal questionnaire consisting of: The BREAST-Q Patient Reported Outcomes Instrument, The European Organisation for Research and Treatment of Cancer QLQ-30 Questionnaire, The Patient and Observer Scar Assessment Scale and a series of Visual-Analogue Scales...
February 13, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28194879/ethanol-production-by-the-hyperthermophilic-archaeon-pyrococcus-furiosus-by-expression-of-bacterial-bifunctional-alcohol-dehydrogenases
#4
Matthew W Keller, Gina L Lipscomb, Diep M Nguyen, Alexander T Crowley, Gerrit J Schut, Israel Scott, Robert M Kelly, Michael W W Adams
Ethanol is an important target for the renewable production of liquid transportation fuels. It can be produced biologically from pyruvate, via pyruvate decarboxylase, or from acetyl-CoA, by alcohol dehydrogenase E (AdhE). Thermophilic bacteria utilize AdhE, which is a bifunctional enzyme that contains both acetaldehyde dehydrogenase and alcohol dehydrogenase activities. Many of these organisms also contain a separate alcohol dehydrogenase (AdhA) that generates ethanol from acetaldehyde, although the role of AdhA in ethanol production is typically not clear...
February 14, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28194591/complications-in-diep-flap-breast-reconstruction-after-mastectomy-for-breast-cancer-a-prospective-cohort-study-comparing-unilateral-and-bilateral-reconstructions
#5
EDITORIAL
Mark V Schaverien, Charles E Butler
No abstract text is available yet for this article.
February 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28187214/what-s-the-remedy-for-the-distal-necrosis-of-diep-flap-better-venous-drain-or-more-arterial-supply
#6
Yi Zhang, Tingliang Wang, Jiao Wei, Jinguang He, Tao Wang, Ying Liu, Hua Xu, Jiasheng Dong
BACKGROUND: We developed a novel pedicled DIEP flap model in rat to explore the possible remedy for the distal necrosis of the flap. METHODS: A deep inferior epigastric perforator (DIEP) flap, based on the second right cranial perforator (P2) as the main pedicle, was elevated in 48 Sprague-Dawley rats. The rats were randomized into 4 groups: group I, the left P2 remaining intact as supercharging; group II, the left P2 artery alone kept as supercharging; group III, the left P2 vein alone kept as supercharging; group IV, no supercharging...
2017: PloS One
https://www.readbyqxmd.com/read/28186875/freezing-of-gait-detection-in-parkinson-s-disease-a-subject-independent-detector-using-anomaly-scores
#7
Thuy T Pham, Steven T Moore, Simon J G Lewis, Diep N Nguyen, Eryk Dutkiewicz, Andrew J Fuglevand, Alistair L McEwan, Philip H W Leong
Freezing of gait (FoG) is common in Parkinsonian gait and strongly relates to falls. Current clinical FoG assessments are patients' self-report diaries and experts' manual video analysis. Both are subjective and yield moderate reliability. Existing detection algorithms have been predominantly designed in subject-dependent settings. In this work, we aim to develop an automated FoG detector for subject-independent. After extracting highly relevant features, we apply anomaly detection techniques to detect FoG events...
February 7, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28144996/audit-of-provincial-ivig-request-forms-and-efficacy-documentation-in-four-ontario-tertiary-care-centres
#8
A W Shih, E Jamula, C Diep, Y Lin, C Armali, N M Heddle, A Traore, J Doherty, N Shah, C M Hillis
OBJECTIVE: Retrospective audit of IVIG Request Forms in four Ontario tertiary care centres: to determine the case mix of new IVIG requests, to authenticate information provided, and to determine documentation of clinical efficacy. AIMS: To understand contributors to increases in IVIG utilisation and to determine whether IVIG is being used and monitored appropriately. INTRODUCTION: Intravenous immunoglobulin (IVIG) use in Canada is high compared with other developed countries...
January 31, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28137816/effects-of-tedizolid-phosphate-on-survival-outcomes-and-suppression-of-production-of-staphylococcal-toxins-in-a-rabbit-model-of-mrsa-necrotizing-pneumonia
#9
Vien T M Le, Hoan N Le, Marcos Gabriel Pinheiro, Kenneth J Hahn, Mary L Dinh, Kajal B Larson, Shawn D Flanagan, Cedric Badiou, Gerard Lina, Christine Tkaczyk, Bret R Sellman, Binh An Diep
The protective efficacy of tedizolid phosphate, a second-generation oxazolidinone that potently inhibits bacterial protein synthesis, was compared to those of linezolid, vancomycin, or saline in a rabbit model of Staphylococcus aureus necrotizing pneumonia. A rabbit dosing regimen of 6 mg/kg tedizolid phosphate IV twice daily, which yielded AUC0-24h values approximating those in humans, was used. Overall survival rate was 83% for rabbits treated with 6 mg/kg tedizolid phosphate twice daily and 83% for those treated with 50 mg/kg linezolid thrice daily (P=0...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28132712/the-triple-functions-of-d2-silencing-in-treatment-of-periapical-disease
#10
Jie Pan, Jue Wang, Liang Hao, Guochun Zhu, Diep N Nguyen, Qian Li, Yuehua Liu, Zhihe Zhao, Yi-Ping Li, Wei Chen
INTRODUCTION: Dental caries is the most widespread chronic infectious disease. Inflammation in pulp tissues caused by dental caries will lead to periapical granulomas, bone erosion, loss of the tooth, and severe pain. Despite numerous efforts in recent studies to develop effective treatments for dental caries, the need for a potent therapy is still urgent. METHODS: In this study, we applied a gene-based therapy approach by administering recombinant adeno-associated virus (AAV)-mediated Atp6v0d2 (d2) RNA interference knockdown of d2 gene expression to prevent periapical bone loss and suppress periapical inflammation simultaneously...
February 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28122466/blood-loss-and-duration-of-surgery-are-independent-risk-factors-for-complications-after-breast-reconstruction
#11
Andri Thorarinsson, Victoria Fröjd, Lars Kölby, Albert Modin, Richard Lewin, Anna Elander, Hans Mark
BACKGROUND: Complications after breast reconstructive surgery are common, and they can be caused by a wide range of factors. The aim of the present study was to identify independent perioperative risk factors for postoperative complications after breast reconstruction. METHODS: A retrospective study was performed of 623 consecutive breast cancer patients who had undergone deep inferior epigastric perforator (DIEP) flap, latissimus dorsi (LD) flap, lateral thoracodorsal flap (LTDF), or tissue expander with secondary implant (EXP)...
January 26, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28115346/targeting-alpha-toxin-to-mitigate-its-lethal-toxicity-in-ferret-and-rabbit-models-of-staphylococcus-aureus-necrotizing-pneumonia
#12
Binh An Diep, Jamese J Hillard, Vien T M Le, Christine Tkaczyk, Hoan N Le, Vuvi G Tran, Renee L Rao, Etyene Castro Dip, Eliane P Pereira-Franchi, Paulyn Cha, Scott Jacobson, Rosemary Broome, Lily I Cheng, William Weiss, Laszlo Prokai, Vien Nguyen, C Ken Stover, Bret R Sellman
The role broad spectrum antibiotics play in the spread of antimicrobial resistance, coupled with their effect on the healthy microbiome have led to advances in pathogen specific approaches for the prevention or treatment of serious bacterial infections. One approach in clinical testing is passive immunization with a monoclonal antibody (mAb) targeting alpha toxin for the prevention or treatment of Staphylococcus aureus pneumonia. Passive immunization with the human anti-alpha toxin mAb, MEDI4893* has been shown to improve disease outcome in murine S...
January 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28106882/combination-of-iap-antagonist-and-ifn%C3%AE-activates-novel-caspase-10-and-ripk1-dependent-cell-death-pathways
#13
Maria C Tanzer, Nufail Khan, James A Rickard, Nima Etemadi, Najoua Lalaoui, Sukhdeep Kaur Spall, Joanne M Hildebrand, David Segal, Maria Miasari, Diep Chau, WendyWei-Lynn Wong, Mark McKinlay, Srinivas K Chunduru, Christopher A Benetatos, Stephen M Condon, James E Vince, Marco J Herold, John Silke
Peptido-mimetic inhibitor of apoptosis protein (IAP) antagonists (Smac mimetics (SMs)) can kill tumour cells by depleting endogenous IAPs and thereby inducing tumour necrosis factor (TNF) production. We found that interferon-γ (IFNγ) synergises with SMs to kill cancer cells independently of TNF- and other cell death receptor signalling pathways. Surprisingly, CRISPR/Cas9 HT29 cells doubly deficient for caspase-8 and the necroptotic pathway mediators RIPK3 or MLKL were still sensitive to IFNγ/SM-induced killing...
January 20, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28097522/severe-aortic-valve-stenosis-in-adults-is-associated-with-increased-levels-of-circulating-intermediate-monocytes
#14
Bernd Hewing, Sebastian Chi-Diep Au, Antje Ludwig, Rena Ellerbroek, Phillip van Dijck, Lisa Hartmann, Herko Grubitzsch, Carolin Giannini, Michael Laule, Verena Stangl, Gert Baumann, Karl Stangl
Individual monocyte subsets have been associated with atherosclerotic disease, but their distribution has not been evaluated in aortic valve stenosis (AS) so far. In the present study, we have asked whether levels of the circulating intermediate monocyte subset are increased in AS. Classical (CD14++CD16-), intermediate (CD14++CD16+), and non-classical (CD14+CD16++) CD86-positive monocytes and monocyte activation (intensity of CD11b expression) were determined by flow cytometry in peripheral blood of patients with severe AS (n = 100) and matched AS-free controls (n = 75)...
January 17, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28095455/novel-porcine-epidemic-diarrhea-virus-pedv-variants-with-large-deletions-in-the-spike-s-gene-coexist-with-pedv-strains-possessing-an-intact-s-gene-in-domestic-pigs-in-japan-a-new-disease-situation
#15
Nguyen Van Diep, Junzo Norimine, Masuo Sueyoshi, Nguyen Thi Lan, Ryoji Yamaguchi
Since late 2013, after an absence of seven years, outbreaks of porcine epidemic diarrhea virus (PEDV) infection have reemerged and swept rapidly across Japan, resulting in significant economic losses. In this study, we report the emergence, mixed infection, and genetic characterization of 15 novel field PEDV variants with large genomic deletions. The sizes of deletion varied between 582 nt (194 aa) and 648 nt (216 aa) at positions 28-714 (10-238) on the S gene (protein). Among 17 PEDV samples isolated from individual pigs, all of them contained at least two distinct genotypes with large genomic deletions, and 94...
2017: PloS One
https://www.readbyqxmd.com/read/28092334/is-enhanced-recovery-the-new-standard-of-care-in-microsurgical-breast-reconstruction
#16
Anoushka Afonso, Sabine Oskar, Kay See Tan, Joseph J Disa, Babak J Mehrara, Jihan Ceyhan, Joseph H Dayan
BACKGROUND: Enhanced recovery pathways (ERPs) have been shown to aid in patient recovery and improve outcomes in many surgical settings. At present, there is limited data available regarding the use and feasibility of ERPs for patients undergoing microsurgical breast reconstruction. We sought to assess patient outcomes before and after the introduction of an ERP that was adopted by multiple surgeons at a single cancer center. METHODS: A multidisciplinary ERP was developed for patients undergoing deep inferior epigastric perforator (DIEP) or muscle-sparing free transverse rectus abdominis myocutaneous (TRAM) flap breast reconstruction...
January 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28092105/effectiveness-of-water-fluoridation-in-the-prevention-of-dental-caries-across-adult-age-groups
#17
Loc Do, Diep Ha, Marco A Peres, John Skinner, Roy Byun, A John Spencer
BACKGROUND: Lifetime access to fluoridated water (FW) is associated with lower caries experience. However, assessing this association in adults is likely affected by age. Cohort stratification and categorization of per cent lifetime access to fluoridated water (% LAFW) within cohorts are current approaches to this assessment. These approaches require an examination of the % LAFW and caries experience variation within and across age groups and their association to inform future analyses...
January 16, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28088025/residues-of-2-hydroxy-3-phenylpyrazine-a-degradation-product-of-some-%C3%AE-lactam-antibiotics-in-environmental-water-in-vietnam
#18
Nguyen Van Sy, Kazuo Harada, Megumi Asayama, Minae Warisaya, Le Hong Dung, Yoshinori Sumimura, Khong Thi Diep, Le Viet Ha, Nguyen Nam Thang, Tran Thi Tuyet Hoa, Tran Minh Phu, Pham Ngoc Khai, Nguyen Thanh Phuong, Le Danh Tuyen, Yoshimasa Yamamoto, Kazumasa Hirata
Antibiotic-resistant bacteria have become a serious problem worldwide, caused in part by the excessive use and discharge of antibiotics into the environment. Ampicillin (ABPC) is a widely used antibiotic. However, this chemical rapidly decomposes in water containing divalent cations like Ca(2+) and Mg(2+), thus, detection of ABPC in environmental water is difficult. This study was carried out to evaluate the presence of 2-hydroxy-3-phenylpyrazine (HPP), one of the degradation products of ABPC and β-lactam antibiotics with an ABPC substructure, in environmental water...
April 2017: Chemosphere
https://www.readbyqxmd.com/read/28079533/national-and-regional-differences-in-32-248-postmastectomy-autologous-breast-reconstruction-using-the-updated-national-inpatient-survey
#19
Parisa Kamali, Marek A Paul, Ahmed M S Ibrahim, Pieter G L Koolen, Winona Wu, Marc L Schermerhorn, Bernard T Lee, Samuel J Lin
BACKGROUND: The incidence of breast cancer (BC) cases has increased significantly. The number of breast reconstruction (BR) procedures performed has mirrored this trend. Although implant-only procedures remain the most commonly used type of immediate BR, autologous techniques involving donor sites account for approximately 20%. The aim of this study was to assess national and regional trends in different types of autologous BR. METHODS: Using the Nationwide Inpatient Sample database (2008 to 2012), data on BC and mastectomy rates, type of autologous BR, and sociodemographics were obtained and analyzed...
January 10, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28065827/gastric-bypass-surgery-recruits-a-gut-ppar-%C3%AE-striatal-d1r-pathway-to-reduce-fat-appetite-in-obese-rats
#20
Mohammed K Hankir, Florian Seyfried, Constantin A Hintschich, Thi-Ai Diep, Karen Kleberg, Mathias Kranz, Winnie Deuther-Conrad, Luis A Tellez, Michael Rullmann, Marianne Patt, Jens Teichert, Swen Hesse, Osama Sabri, Peter Brust, Harald S Hansen, Ivan E de Araujo, Ute Krügel, Wiebke K Fenske
Bariatric surgery remains the single most effective long-term treatment modality for morbid obesity, achieved mainly by lowering caloric intake through as yet ill-defined mechanisms. Here we show in rats that Roux-en-Y gastric bypass (RYGB)-like rerouting of ingested fat mobilizes lower small intestine production of the fat-satiety molecule oleoylethanolamide (OEA). This was associated with vagus nerve-driven increases in dorsal striatal dopamine release. We also demonstrate that RYGB upregulates striatal dopamine 1 receptor (D1R) expression specifically under high-fat diet feeding conditions...
February 7, 2017: Cell Metabolism
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