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https://www.readbyqxmd.com/read/28724662/the-role-of-antibiotics-in-modulating-virulence-in-staphylococcus-aureus
#1
REVIEW
Elisabeth Hodille, Warren Rose, Binh An Diep, Sylvain Goutelle, Gerard Lina, Oana Dumitrescu
Staphylococcus aureus is often involved in severe infections, in which the effects of bacterial virulence factors have great importance. Antistaphylococcal regimens should take into account the different effects of antibacterial agents on the expression of virulence factors and on the host's immune response. A PubMed literature search was performed to select relevant articles on the effects of antibiotics on staphylococcal toxin production and on the host immune response. Information was sorted according to the methods used for data acquisition (bacterial strains, growth models, and antibiotic concentrations) and the assays used for readout generation...
October 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28713853/factors-associated-with-acute-postoperative-pain-following-breast-reconstruction
#2
Anita R Kulkarni, Andrea L Pusic, Jennifer B Hamill, Hyungjin M Kim, Ji Qi, Edwin G Wilkins, Randy S Roth
INTRODUCTION: Post-mastectomy breast reconstruction has become an increasingly important component of breast cancer treatment. Unfortunately, some patients experience severe postoperative pain, placing them at risk for increased clinical morbidity and the development of disabling chronic pain. In an attempt to identify at-risk patients, we prospectively evaluated patient characteristics and medical/surgical variables associated with more severe acute post-reconstruction pain. METHODS: Women (N = 2207; one-week 82...
March 2017: JPRAS Open
https://www.readbyqxmd.com/read/28711861/healthcare-infrastructure-capacity-to-respond-to-severe-acute-respiratory-infection-sari-and-sepsis-in-vietnam-a-low-middle-income-country
#3
Vu Quoc Dat, Nguyen Thanh Long, Kim Bao Giang, Pham Bich Diep, Ta Hoang Giang, Janet V Diaz
PURPOSE: This study investigated the availability of relevant structural and human resources needed for the clinical management of patients with severe acute respiratory infections and sepsis in critical care units in Vietnam. MATERIAL AND METHODS: A questionnaire survey was conducted by purposive sampling of 128 hospitals (36% of total hospitals in surveyed provinces), including 25 provincial and 103 district level hospitals, from 20 provinces in Vietnam. Data on availability of hospital characteristics, structural resources and health care workers was then analyzed...
July 10, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28705956/rapid-recovery-gene-downregulation-during-excess-light-stress-and-recovery-in-arabidopsis
#4
Peter Alexander Crisp, Diep Ganguly, Aaron B Smith, Kevin D Murray, Gonzalo M Estavillo, Iain R Searle, Ethan Ford, Ozren Bogdanović, Ryan Lister, Justin O Borevitz, Steven R Eichten, Barry J Pogson
Stress recovery may prove to be a promising approach to increase plant performance, and theoretically, mRNA instability may facilitate faster recovery. Transcriptome (RNA-seq, qPCR, sRNA-seq, PARE) and methylome profiling during repeated excess-light stress and recovery was performed at intervals as short as three minutes. We demonstrate that 87% of the stress-upregulated mRNAs analysed exhibit very rapid recovery. For instance, HSP101 abundance declined two-fold every 5.1 minutes. We term this phenomenon Rapid Recovery Gene Downregulation (RRGD), whereby mRNA abundance rapidly decreases promoting transcriptome resetting...
July 13, 2017: Plant Cell
https://www.readbyqxmd.com/read/28705933/two-functionally-distinct-nadp-dependent-ferredoxin-oxidoreductases-maintain-the-primary-redox-balance-of-pyrococcus-furiosus
#5
Diep M N Nguyen, Gerrit J Schut, Oleg A Zadvornyy, Monika Tokmina-Lukaszewska, Saroj Poudel, Gina L Lipscomb, Leslie A Adams, Jessica T Dinsmore, William J Nixon, Eric S Boyd, Brian Bothner, John W Peters, Michael W W Adams
Electron bifurcation has recently gained acceptance as the third mechanism of energy conservation in which energy is conserved through the coupling of exergonic and endergonic reactions. A structure-based mechanism of bifurcation has been elucidated recently for the flavin-based enzyme NADH-dependent ferredoxin NADP+ oxidoreductase I (NfnI) from the hyperthermophillic archaeon Pyrococcus furiosus. NfnI is thought to be involved in maintaining the cellular redox balance, producing NADPH for biosynthesis by recycling the two other primary redox carriers, NADH and ferredoxin...
July 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28703885/use-of-a-72-cm-long-extended-bilateral-deep-inferior-epigastric-artery-perforator-free-flap-for-reconstruction-of-a-lower-leg-with-no-suitable-recipient-vessel-around-the-injury-zone-a-case-report
#6
Hidehiko Yoshimatsu, Takumi Yamamoto, Akitatsu Hayashi, Takuya Iida
In free-flap reconstruction of the lower extremity, due either to trauma or pre-existing vascular disease, healthy vessels may not be readily available in the proximity of the defect. A variety of options including a cross-leg free flap, vein grafts, arteriovenous loops, and "bridging" flaps have been used to address the issue. The purpose of this report is to present a case in which a 72-cm long extended bilateral deep inferior epigastric artery perforator (DIEP) free flap was used for coverage of a 20 × 25 cm soft tissue defect of the lower leg following a Gustilo grade IIIC fracture in a 29-year-old man...
July 13, 2017: Microsurgery
https://www.readbyqxmd.com/read/28699575/proposal-to-reclassify-ehrlichia-muris-as-ehrlichia-muris-subsp-muris-subsp-nov-and-description-of-ehrlichia-muris-subsp-eauclairensis-subsp-nov-a-newly-recognized-tick-borne-pathogen-of-humans
#7
Bobbi S Pritt, Michelle E J Allerdice, Lynne M Sloan, Christopher D Paddock, Ulrike G Munderloh, Yasuko Rikihisa, Tomoko Tajima, Susan M Paskewitz, David F Neitzel, Diep K Hoang Johnson, Elizabeth Schiffman, Jeffrey P Davis, Cynthia S Goldsmith, Curtis M Nelson, Sandor E Karpathy
We have previously described a novel taxon of the genus Ehrlichia (type strain WisconsinT), closely related to Ehrlichia muris, that causes human ehrlichiosis among patients with exposures to ticks in the upper midwestern USA. DNA from this bacterium was also detected in Ixodes scapularis and Peromyscus leucopus collected in Minnesota and Wisconsin. To determine the relationship between the E. muris-like agent (EMLA) and other species of the genus Ehrlichia phenotypic, genotypic and epidemiologic comparisons were undertaken, including sequence analysis of eight gene loci (3906 nucleotides) for 39 EMLA DNA samples and the type strain of E...
July 12, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28699133/survival-rates-for-patients-with-resected-gastric-adenocarcinoma-finally-have-increased-in-the-united-states
#8
Elliot G Arsoniadis, Schelomo Marmor, Gustave K Diep, Jane Yuet Ching Hui, Eric H Jensen, Todd M Tuttle
BACKGROUND: In the United States, the overall survival rates for gastric adenocarcinoma have remained low, with surgical resection as the only therapy for many patients. Given the advances in multimodality treatment and the development of guidelines recommending adequate lymph node evaluation, the authors determined whether overall survival rates for patients with gastric adenocarcinoma have increased in the United States. METHODS: The study used the Surveillance Epidemiology and End Results (SEER) database to examine overall survival for patients with the diagnosis of gastric adenocarcinoma between 1988 and 2013...
July 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28695998/co-surgeons-in-breast-reconstructive-microsurgery-what-do-they-bring-to-the-table
#9
Nicholas T Haddock, Samar Kayfan, Ronnie A Pezeshk, Sumeet S Teotia
INTRODUCTION: Current research within other surgical specialties suggests that a co-surgeon approach may reduce operative times and complications associated with complex bilateral procedures, possibly leading to improved patient and surgical outcomes. We sought to evaluate the role of the co-surgery team and its development in free flap breast reconstruction. METHODS: A retrospective review of free-flap breast reconstruction by two surgeons from 2011 to 2016 was conducted...
July 11, 2017: Microsurgery
https://www.readbyqxmd.com/read/28693999/-profunda-artery-perforator-flap-reliable-secondary-option-for-breast-reconstruction
#10
P Fosseprez, A Gerdom, M Servaes, C Deconinck, G Pirson, A Berners
BACKGROUND: In recent years, the DIEP-flap has become the standard for autologous breast reconstruction. However, when abdominal donor site is unavailable, secondary options are numerous. This report documents our experience with PAP-flap breast reconstruction. METHOD: We carried out a retrospective study of patients who underwent reconstructive breast surgery by PAP-flaps in our institution since 2014. RESULTS: Seventeen PAP-flaps were carried out in 15 patients, two of which received consecutive reconstruction of each breast at distinct intervals...
July 7, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28685899/prevention-and-recognition-of-abusive-head-trauma-training-for-healthcare-professionals-in-vietnam
#11
Jennifer A Fraser, Tara Flemington, Thi Ngoc Diep Doan, Minh Tu Van Hoang, Thi Le Binh Doan, Manh Tuan Ha
AIM: This paper presents results from an intervention designed to improve identification and response to abusive head trauma in a tertiary paediatric hospital in Vietnam. METHODS: One hundred and sixteen healthcare professionals (paediatric medical and nursing staff) completed a clinical training programme and participated in its evaluation. A pre-post-test and follow-up design was used to evaluate the outcomes. Questionnaires were used to collect data prior to training, at six-weeks and at six-months...
July 7, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28684286/donor-site-morbidity-in-diep-free-flap-breast-reconstructions-a-comparison-of-unilateral-bilateral-and-bipedicled-surgical-procedure-types
#12
Taj Tomouk, Anita T Mohan, Alex Azizi, Elena Conci, Elizabeth B Brickley, Charles M Malata
BACKGROUND: The use of abdominal tissue in post-mastectomy autologous breast reconstruction is a popular choice among reconstructive surgeons. This is the first study to evaluate donor complications comparing unilateral, bilateral, and bipedicled DIEP breast reconstructions. METHODS: A retrospective chart review was conducted of all women undergoing rib-preserving DIEP free flap breast reconstruction at a University Hospital between 2008 and 2015 by the senior surgeon (CMM)...
June 3, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28659507/pressor-response-to-angiotensin-ii-is-enhanced-in-aged-mice-and-associated-with-inflammation-vasoconstriction-and-oxidative-stress
#13
Quynh Nhu Dinh, Grant R Drummond, Barbara K Kemp-Harper, Henry Diep, T Michael De Silva, Hyun Ah Kim, Antony Vinh, Avril A B Robertson, Matthew A Cooper, Ashley Mansell, Sophocles Chrissobolis, Christopher G Sobey
Aging is commonly associated with chronic low-grade inflammation and hypertension but it is unknown whether a cause-effect relationship exists between them. We compared the sensitivity of young adult (8-12 w) and aged (23-31 mo) male C57Bl6J mice to develop hypertension in response to a slow-pressor dose of angiotensin II (Ang II; 0.28 mg/kg/d; 28 d). In young mice, the pressor response to Ang II was gradual and increased to 142±8 mmHg over 28 d. However, in aged mice, Ang II promptly increased SBP and reached 155±12 mmHg by 28 d...
June 28, 2017: Aging
https://www.readbyqxmd.com/read/28654607/discussion-selective-intraoperative-vasopressor-use-is-not-associated-with-increased-risk-of-diep-flap-complications
#14
Matthew M Hanasono, Peirong Yu
No abstract text is available yet for this article.
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654606/discussion-selective-intraoperative-vasopressor-use-is-not-associated-with-increased-risk-of-diep-flap-complications
#15
Joon Pio Jp Hong, Hyun Suk Peter Suh
No abstract text is available yet for this article.
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654605/selective-intraoperative-vasopressor-use-is-not-associated-with-increased-risk-of-diep-flap-complications
#16
Ashley Szabo Eltorai, Chuan-Chin Huang, Jeffrey T Lu, Asako Ogura, Stephanie A Caterson, Dennis P Orgill
BACKGROUND: During deep inferior epigastric perforator (DIEP) flap cases, anesthesiologists commonly avoid intravenous vasopressor administration because of the theoretical concern of inducing vasospasm, thrombosis, or congestion in the vessels of the anastomosis, potentially resulting in poor flap perfusion and ischemia and necessitating revision. In the setting of hypotension, however, vasopressor administration may actually improve outcomes by augmenting flap perfusion by means of increased mean arterial pressure...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654582/predictors-classification-and-management-of-umbilical-complications-in-diep-flap-breast-reconstruction
#17
Min-Jeong Cho, Sumeet S Teotia, Nicholas T Haddock
BACKGROUND: In recent years, the deep inferior epigastric perforator (DIEP) flap has become the workhorse flap for autologous breast reconstruction. Despite increased reports on DIEP flaps, umbilical complications have not been previously studied. The aesthetics of the umbilicus dictates the beauty of the abdomen, and it is critical for plastic surgeons to minimize the scarring of the umbilicus. In this study, we retrospectively reviewed patients who underwent DIEP flaps to determine the predictors of umbilical complications, and created a classification system of these wounds...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28643199/airway-arteriovenous-malformation-in-pregnancy
#18
Jack Diep, Kartik Dandu, Ming Xiong, Steven M Shulman, Antonio J Gonzalez-Fiol
No abstract text is available yet for this article.
June 22, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28615449/equilibrium-and-ultrafast-kinetic-studies-manipulating-electron-transfer-a-short-lived-flavin-semiquinone-is-not-sufficient-for-electron-bifurcation
#19
John P Hoben, Carolyn E Lubner, Michael W Ratzloff, Gerrit J Schut, Diep M N Nguyen, Karl W Hempel, Michael W W Adams, Paul W King, Anne-Frances Miller
Flavin-based electron transfer bifurcation is emerging as a fundamental and powerful mechanism for conservation and deployment of electrochemical energy in enzymatic systems. In this process, a pair of electrons is acquired at intermediate reduction potential (i.e. intermediate reducing power) and each electron is passed to a different acceptor, one with lower and the other with higher reducing power, leading to 'bifurcation'. It is believed that a strongly reducing semiquinone species is essential for this process, and it is expected that this species should be kinetically short-lived...
June 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28614316/rapid-direct-laser-writing-of-desired-plasmonic-nanostructures
#20
Quang Cong Tong, Mai Hoang Luong, Jacqueline Remmel, Minh Thanh Do, Dam Thuy Trang Nguyen, Ngoc Diep Lai
We demonstrate a direct way to realize arbitrary gold nanostructures via a local dewetting method. This technique was based on the optically induced local thermal effect at the focusing region of a direct laser writing (DLW) system employing a green continuous-wave laser. The local high temperature allowed the creation of gold nano-islands only at the focusing area of the optical system. By moving the focusing spot, this DLW method allowed us to "write" desired two-dimensional gold patterns with a feature size down to sub-lambda...
June 15, 2017: Optics Letters
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