keyword
https://read.qxmd.com/read/38546357/discussion-indocyanine-green-guided-near-infrared-fluorescence-enhances-vascular-anatomy-in-robot-assisted-diep-flap-harvest
#1
JOURNAL ARTICLE
Andres Mascaro Pankova, Lisandro Montorfano
No abstract text is available yet for this article.
April 1, 2024: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38540185/xylosyltransferase-deficiency-in-human-dermal-fibroblasts-induces-compensatory-myofibroblast-differentiation-and-long-term-ecm-reduction
#2
JOURNAL ARTICLE
Anika Kleine, Matthias Kühle, Thanh-Diep Ly, Vanessa Schmidt, Isabel Faust-Hinse, Cornelius Knabbe, Bastian Fischer
Desbuquois dysplasia type 2 (DBQD2) and spondylo-ocular syndrome (SOS) are autosomal recessive disorders affecting the extracellular matrix (ECM) and categorized as glycosaminoglycan (GAG) linkeropathies. Linkeropathies result from mutations within glycosyltransferases involved in the synthesis of the tetrasaccharide linker, a linker between the core protein of proteoglycan (PG) and GAG. DBQD2 and SOS are caused by the isolated mutations of the xylosyltransferase (XT) isoforms. In this work, we successfully generated XYLT1 - as well as XYLT2 -deficient GAG linkeropathy model systems in human dermal fibroblasts using a ribonucleoprotein-based CRISPR/Cas9-system...
March 4, 2024: Biomedicines
https://read.qxmd.com/read/38531037/daptomycin-induced-eosinophilic-pneumonia
#3
JOURNAL ARTICLE
Michael R Hassett
Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare complication of daptomycin use. Manifestations most commonly include fever, hypoxia, dyspnea, cough, eosinophilia, and lung changes on radiographs and CT. Patients typically have had recent daptomycin exposure and develop fever, dyspnea, infiltrates on chest radiograph, more than 25% eosinophils on bronchoalveolar lavage, and improvement of symptoms after withdrawal of daptomycin. Treatment includes discontinuation of daptomycin, corticosteroids, and supportive measures such as supplemental oxygen...
April 1, 2024: JAAPA: Official Journal of the American Academy of Physician Assistants
https://read.qxmd.com/read/38528844/initial-experience-with-unidirectional-barbed-suture-for-abdominal-donor-site-closure-in-deep-inferior-epigastric-perforator-flap-breast-reconstruction
#4
JOURNAL ARTICLE
Emily R Finkelstein, Abdel-Moneim Mohamed Ali, Tripp Holton, Benjamin Slavin, Susan Taghioff, Juan Mella-Catinchi, Devinder Singh
BACKGROUND: The deep inferior epigastric perforator (DIEP) flap is a predominant technique for autologous breast reconstruction. However, the best method of abdominal fascial closure in this technique is not well defined. This study details our initial experience with unidirectional barbed suture-only repair of abdominal donor site fascia. METHODS: Patients who underwent DIEP flap breast reconstruction and abdominal fascial closure with Stratafix Symmetric Polydioxanone PDS Plus were retrospectively reviewed...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38525531/optimization-of-mouse-kidney-digestion-protocols-for-single-cell-applications
#5
JOURNAL ARTICLE
Jake N Robertson, Henry Diep, Alexander Pinto, Christopher G Sobey, Grant R Drummond, Antony Vinh, Maria Jelinic
Single-cell technologies such as flow cytometry and single-cell RNA sequencing (scRNAseq) have allowed for comprehensive characterisation of the kidney cellulome. However, there is disparity in the various protocols for preparing kidney single-cell suspensions. We aimed to address this limitation by characterising kidney cellular heterogeneity using three previously published single-cell preparation protocols. Single-cell suspensions were prepared from male and female C57BL/6 kidneys using the following kidney tissue dissociation protocols: (P1) a scRNAseq protocol; (P2) a multi-tissue digestion kit from Miltenyi Biotec ; and (P3) a protocol established in our laboratory...
March 25, 2024: Physiological Genomics
https://read.qxmd.com/read/38519026/similar-risk-of-kidney-failure-among-patients-with-blinding-diseases-who-receive-ranibizumab-aflibercept-and-bevacizumab-an-ohdsi-network-study
#6
JOURNAL ARTICLE
Cindy X Cai, Akihiko Nishimura, Mary G Bowring, Erik Westlund, Diep Tran, Jia H Ng, Paul Nagy, Michael Cook, Jody-Ann McLeggon, Scott L DuVall, Michael E Matheny, Asieh Golozar, Anna Ostropolets, Evan Minty, Priya Desai, Fan Bu, Brian Toy, Michelle Hribar, Thomas Falconer, Linying Zhang, Laurence Lawrence-Archer, Michael V Boland, Kerry Goetz, Nathan Hall, Azza Shoaibi, Jenna Reps, Anthony G Sena, Clair Blacketer, Joel Swerdel, Kenar D Jhaveri, Edward Lee, Zachary Gilbert, Scott L Zeger, Deidra C Crews, Marc A Suchard, George Hripcsak, Patrick B Ryan
OBJECTIVE OR PURPOSE: A) To characterize the incidence of kidney failure associated with intravitreal anti-vascular endothelial growth factor (VEGF) exposure, and B) compare the risk of kidney failure in patients treated with ranibizumab, aflibercept, or bevacizumab. DESIGN: Retrospective cohort study across 12 databases in the Observational Health Data Sciences and Informatics (OHDSI) network. SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: Subjects aged ≥18 years with ≥3 monthly intravitreal anti-VEGF medications for a blinding disease (diabetic retinopathy, diabetic macular edema, exudative age-related macular degeneration, or retinal vein occlusion)...
March 20, 2024: Ophthalmology Retina
https://read.qxmd.com/read/38518931/effects-of-radiation-dose-and-dose-rate-on-alginate-and-the-use-of-radiation-degraded-alginate-for-peanut
#7
JOURNAL ARTICLE
Nguyen Van Binh, Hoang Dang Sang, Tran Bang Diep, Tran Xuan An, Hoang Phuong Thao, Tran Minh Quynh
Aqueous solutions of alginate (4 %) with or without hydrogen peroxide (0-2 % H2 O2 ) were irradiated under a gamma Co-60 source. The effect of dose rate on the radiation scission yield (Gs) of resulting irradiated alginate was determined. At the dose of 20 kGy, the G(s) value of irradiated alginate decreased with the increase dose rate, suggesting that the irradiation at a suitable dose rate could further improve the radiation chemical yield of degradation. For the alginate irradiated at the same dose rate, G(s) value increased with the increase of H2 O2 concentration...
March 20, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38516731/comtrifosides-a-and-b-two-new-triterpenoid-saponins-from-the-leaves-of-combretum-trifoliatum
#8
JOURNAL ARTICLE
Cong Thai Son Nguyen, Thanh Hoa Vo, Nguyen Kim Tuyen Pham, Bui Linh Chi Huynh, Trong Nghia Ngo, Van Son Dang, Thi Kim Chi Huynh, Trong Dat Bui, Diep Xuan Ky Nguyen, Nhat Minh Phan, Dinh Tri Mai, Kim Phi Phung Nguyen, Tan Phat Nguyen
The phytochemical composition of the Combretum trifoliatum leaves was studied for the first time. Two new triterpenoid saponins, named comtrifoside A ( 1 ) and comtrifoside B ( 2 ), together with two other saponins ( 3-4 ) were purified by variously chromatographic techniques. For the first time, compound 3 was informed from the Combretum genus, as well as all of the isolated compounds ( 1-4 ) were reported from C. trifoliatum . The chemical structures of them were clearly characterised using extensive UV-VIS, IR, HRMS-ESI, and NMR experimental data...
March 22, 2024: Natural Product Research
https://read.qxmd.com/read/38515559/an-effective-protocol-for-perioperative-venous-thromboembolism-prophylaxis-in-diep-flap-breast-reconstruction-a-single-institution-retrospective-review
#9
JOURNAL ARTICLE
Mathew L Moreno, Hunter Essex, Meredith Collins
BACKGROUND: Deep inferior epigastric artery perforator (DIEP) free flap breast reconstruction is one of the most highly used procedures for autologous breast reconstruction. Many venous thromboembolism (VTE) risk assessment models have been proposed in breast reconstructive surgery, including the widely used Caprini score. However, a paucity of data suggests an effective standardized VTE protocol. The purpose of this study was to determine the rate of VTE in our DIEP flap patients who were treated with this protocol...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38507549/-diep-flap-vs-pap-flap-vs-lap-flap-a-propensity-matched-analysis-of-aesthetic-outcomes-complications-and-satisfaction
#10
JOURNAL ARTICLE
Nicholas T Haddock, Alexis C Lakatta, Cyrus Steppe, Sumeet S Teotia
INTRODUCTION: As free breast reconstruction options evolve, a patient and body centric approach can distinguish refined aesthetic outcomes. While DIEP, PAP, and LAP flaps are all safe and effective options for breast reconstruction, a head-to-head analysis of these three flaps has not been performed. We aim to compare these three flaps based on outcomes, BREAST-Q, and aesthetic results. METHODS: After IRB approval, a retrospective review in a REDCap database guided analysis of patients who underwent simultaneous bilateral DIEP, PAP, or LAP flaps at a single academic institution...
March 19, 2024: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38503427/progress-towards-health-equity-in-vietnam-evidence-from-nationwide-official-health-statistics-2010-2020
#11
JOURNAL ARTICLE
Yikai Feng, Tran Diep Tuan, Junyi Shi, Zhuo Li, Mailikezhati Maimaitiming, Yinzi Jin, Zhijie Zheng
INTRODUCTION: One of the ultimate goals of strengthening the health system is to achieve health equity. Vietnam is considered one of the 'fast-track countries' to achieve the health-related Millennium Development Goals, but research on its equity strategies remains inadequate. METHODS: Using Vietnamese official health statistics, we investigated inequity in four dimensions including health resources, service delivery, service utilisation and residents' health status from the perspectives of income levels, poverty rates and subnational regions...
March 18, 2024: BMJ Global Health
https://read.qxmd.com/read/38500393/robotic-repair-an-alternative-technique-for-rectus-diastasis-and-abdominal-bulge-following-diep-flap-breast-reconstruction
#12
JOURNAL ARTICLE
Kaila Herold, Timothy Stoddard, Nelson Rodriguez-Unda, John LoGiudice, Patrick Hettinger, Rana M Higgins, Erin L Doren
BACKGROUND: The Deep Inferior Epigastric Artery Perforator (DIEP) flap is the gold standard in autologous breast reconstruction. Despite advances in perforator dissection, abdominal morbidity still occurs. Traditional rectus diastasis (RD), abdominal bulge, and hernia repair with open techniques are associated with higher complication rates and recurrence. OBJECTIVES: We present a novel case series of robotic repair of symptomatic RD and/or abdominal bulge with concurrent hernia following DIEP flap surgery...
March 19, 2024: Aesthetic Surgery Journal
https://read.qxmd.com/read/38497518/social-risk-groups-in-patients-with-diabetes-with-differing-eye-care-utilization-and-vision-outcomes
#13
JOURNAL ARTICLE
Cindy X Cai, Dingfen Han, Diep Tran, Jose Amezcua Moreno, Scott L Zeger, Deidra C Crews
PURPOSE: To evaluate whether latent class analysis on social determinants of health (SDoH) data can identify social risk groups that differ by adverse SDoH and vision outcomes in patients with diabetes. METHODS: This was a prospective cohort study of adults ≥18 years with diabetes who completed a SDoH survey. Latent class analysis was used to cluster patients into social risk groups. The association of social risk group and severity of diabetic retinopathy, history of lapses in diabetic retinopathy care, and visual acuity was evaluated...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38496554/-de-novo-tangled1-recruitment-to-aberrant-cell-plate-fusion-sites-in-maize
#14
Aimee N Uyehara, Beatrice N Diep, Lindy A Allsman, Sarah G Gayer, Stephanie E Martinez, Janice J Kim, Shreya Agarwal, Carolyn G Rasmussen
UNLABELLED: Division plane positioning is critical for proper growth and development in many organisms. In plants, the division plane is established before mitosis, by accumulation of a cytoskeletal structure called the preprophase band (PPB). The PPB is thought to be essential for recruitment of division site localized proteins, which remain at the division site after the PPB disassembles. Here, we show that a division site localized protein, TANGLED1 (TAN1), is recruited independently of the PPB to the cell cortex at sites, by the plant cytokinetic machinery, the phragmoplast...
March 8, 2024: bioRxiv
https://read.qxmd.com/read/38493540/effect-of-corticosteroids-on-ischemia-reperfusion-injury-of-deep-inferior-epigastric-perforator-flap-after-re-exploration-for-anastomosis-thrombosis-a-prospective-randomized-trial
#15
JOURNAL ARTICLE
Simone La Padula, Pasquale M Bufalino, Romain Bosc, Michele Maruccia, Rossella Elia, Francesco D'Andrea, Jean P Meningaud, Barbara Hersant, Rosita Pensato
Patients undergoing breast reconstruction with the deep inferior epigastric perforator (DIEP) flap are at risk of arterial and venous thrombosis, necessitating flap salvage surgery. However, this carries the risk of ischemia-reperfusion injury (IRI) and potential significant partial or complete flap loss. The objective of this study was to evaluate the potential benefit of corticosteroids in reducing IRI related complications in DIEP flaps that are returned to the operation theater for attempted salvage after venous or arterial failure...
February 29, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38489983/secondary-solution-for-breast-reconstruction-following-total-diep-flap-loss-a-single-center-experience-after-3270-diep-flaps
#16
JOURNAL ARTICLE
R J Musmann, C Andree, B Munder, M Hagouan, D Janku, M Daniels, B Aufmesser-Freyhardt, K Becker, A Oramary, A Bromba, N Stockhausen, A Wolter, S Fertsch
BACKGROUND: Total deep inferior epigastric perforator (DIEP) flap failure is a significant concern in autologous breast reconstruction. Literature on secondary reconstruction options following total flap failure is limited. This study outlines the outcomes of patients who underwent reconstruction post-DIEP flap failure at our institution. METHODS: We conducted a retrospective analysis of patients receiving autologous breast reconstruction between 2004 and 2021. We aimed to identify causes of total DIEP flap failure, outcomes of revision surgery, and outcomes of secondary breast reconstruction procedures...
February 28, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38482922/neurotoxic-microglial-activation-via-ifn%C3%AE-induced-nrf2-reduction-exacerbating-alzheimer-s-disease
#17
JOURNAL ARTICLE
You Jung Kang, Seung Jae Hyeon, Amanda McQuade, Jiwoon Lim, Seung Hyun Baek, Yen N Diep, Khanh V Do, Yeji Jeon, Dong-Gyu Jo, C Justin Lee, Mathew Blurton-Jones, Hoon Ryu, Hansang Cho
Microglial neuroinflammation appears to be neuroprotective in the early pathological stage, yet neurotoxic, which often precedes neurodegeneration in Alzheimer's disease (AD). However, it remains unclear how the microglial activities transit to the neurotoxic state during AD progression, due to complex neuron-glia interactions. Here, the mechanism of detrimental microgliosis in AD by employing 3D human AD mini-brains, brain tissues of AD patients, and 5XFAD mice is explored. In the human and animal AD models, amyloid-beta (Aβ)-overexpressing neurons and reactive astrocytes produce interferon-gamma (IFNγ) and excessive oxidative stress...
March 14, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38478464/navigating-cultural-and-gender-aspects-of-stigma-among-women-living-with-hiv-in-vietnam
#18
JOURNAL ARTICLE
Chunqing Lin, Diep Bich Nguyen, Lynn Nguyen, Trang Thu Nguyen, Li Li, Le Minh Giang
Women living with HIV often face intersecting challenges of stigma and gender inequality. In Vietnam, this issue is potentially exacerbated by the patriarchal culture. From December 2021 to March 2022, we conducted in-depth interviews with 30 women living with HIV in Hanoi to better understand their experiences and the coping mechanisms to navigate HIV stigma, cultural beliefs and gender norms. The interviews explored various topics including women's social and family roles in Vietnam, HIV-related beliefs, stigma and its impact on one's health and coping strategies...
March 13, 2024: Culture, Health & Sexuality
https://read.qxmd.com/read/38470816/free-tissue-transfer-for-reconstruction-after-bilateral-skin-sparing-mastectomy-a-systematic-review
#19
JOURNAL ARTICLE
Florian Bucher, Peter M Vogt, Nicco Krezdorn, Khaled Dastagir
BACKGROUND: Breast cancer is the most commonly diagnosed malignant neoplasia in females worldwide. Overall survival and patients' choice for bilateral mastectomy have increased. It is therefore important to offer breast reconstructive procedures to improve patient quality of life and self-esteem. The aim of this systematic literature review is to quantify the outcome and sustainability of bilateral breast reconstruction using autologous, vascularized free tissue transfer. METHODS: A systematic literature review of PubMed, Cochrane, and the Web of Science databases was performed...
February 29, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38468301/unraveling-reproductive-and-maternal-health-challenges-of-women-living-with-hiv-aids-in-vietnam-a-qualitative-study
#20
JOURNAL ARTICLE
Lynn T Nguyen, Le Minh Giang, Diep B Nguyen, Trang T Nguyen, Chunqing Lin
BACKGROUND: Human Immunodeficiency Virus (HIV) remains a significant public health concern worldwide. Women living with HIV/AIDS (WLHA) have the additional and unique need to seek sexual and reproductive health services. WLHA's maternal health journeys can be shaped by the cultural norms and resources that exist in their society. This study sought to understand if and how WLHA's family planning, pregnancy, and motherhood experiences could be influenced by the patriarchal culture, gender roles, and HIV stigma in Vietnam, specifically...
March 11, 2024: Reproductive Health
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