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https://www.readbyqxmd.com/read/29149533/monocyte-specific-knockout-of-c-ebp%C3%AE-results-in-osteopetrosis-phenotype-blocks-bone-loss-in-ovariectomized-mice-and-reveals-an-important-function-of-c-ebp%C3%AE-in-osteoclast-differentiation-and-function
#1
Wei Chen, Guochun Zhu, Joel Jules, Diep Nguyen, Yi-Ping Li
CCAAT/enhancer-binding protein α (C/ebpα) is critical for osteoclastogenesis by regulating osteoclast (OC) lineage commitment and is also important for OC differentiation and function in vitro. However, the role of C/ebpα in postnatal skeletal development has not been reported owing to lethality in C/ebpα(-/-) mice from hypoglycemia within 8 hours after birth. Herein, we generated conditional knockout mice by deleting the C/ebpα gene in monocyte via LysM-Cre to examine its role in OC differentiation and function...
November 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29128672/long-term-immune-reconstitution-after-matched-unrelated-hematopoietic-stem-cell-transplantation-for-immunodeficiency
#2
Vy Hong-Diep Kim, Brenda Reid, Adelle Atkinson, Julia Upton, Eyal Grunebaum, Chaim M Roifman
No abstract text is available yet for this article.
November 8, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29127470/rectus-abdominis-muscle-innervation-an-anatomical-study-with-surgical-implications-in-diep-flap-harvesting
#3
Carla Stecco, Gian Paolo Azzena, Veronica Macchi, Andrea Porzionato, Astrid Behr, Anna Rambaldo, Cesare Tiengo, Raffaele De Caro
PURPOSE: To improve the current knowledge of rectus abdominis innervation, so as to identify a safe area where the vascular pedicle should be dissected to reduce the risk of nerve damage during deep inferior epigastric perforator (DIEP) flap harvesting. METHODS: Ten abdominal wall dissections were performed. Perforating arteries were identified and classified into nerve-related perforators and non-nerve-related perforators depending on the presence of nerve branches crossing vessels...
November 10, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29122498/a-single-centre-retrospective-proof-of-concept-review-of-salvage-of-infected-or-exposed-implant-breast-reconstructions-with-explantation-and-one-stage-free-flap-replacement
#4
Russell J Bramhall, Izaro Hernan, Paul A Harris
INTRODUCTION: Implant-based breast reconstruction has relatively high complication rates. Removal of infected implants and immediate autologous reconstruction is a safe single-stage procedure that preserves the native breast skin envelope. METHODS: A single-centre, retrospective proof-of-concept review of all salvage procedures performed for acute/chronic infected or exposed implant-based reconstructions by a single surgeon over a 6-year period. RESULTS: We present 13 cases of a particularly difficult subgroup of acute/chronic infection/extrusion over a 6-year period...
October 18, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29093819/the-impact-of-borderline-personality-disorder-and-sub-threshold-borderline-personality-disorder-on-the-course-of-self-reported-and-clinician-rated-depression-in-self-harming-adolescents
#5
Ruth-Kari Ramleth, Berit Groholt, Lien M Diep, Fredrik A Walby, Lars Mehlum
Background: Studies on adults suggest that the presence of comorbid depression and Borderline Personality Disorder (BPD) is associated with an elevated risk of self-harming behaviours and that self-harming behaviours, when present, will have higher severity. This comorbidity, furthermore, complicates clinical assessments, which may be an obstacle to early identification and proper intervention. Adolescents who self-harm frequently report high levels of depressive symptoms, but this is often not reflected in the clinicians' assessment...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/29093180/the-fcrn-inhibitor-rozanolixizumab-reduces-human-serum-igg-concentration-a-randomized-phase-1-study
#6
Peter Kiessling, Rocio Lledo-Garcia, Shikiko Watanabe, Grant Langdon, Diep Tran, Muhammad Bari, Louis Christodoulou, Emma Jones, Graham Price, Bryan Smith, Frank Brennan, Ian White, Stephen Jolles
Pathogenic immunoglobulin G (IgG) autoantibodies characterize some human autoimmune diseases; their high concentration and long half-life are dependent on recycling by the neonatal Fc receptor (FcRn). Inhibition of FcRn is an attractive new treatment concept for IgG-mediated autoimmune diseases. Rozanolixizumab (UCB7665; CA170_01519.g57 IgG4P) is an anti-human FcRn monoclonal antibody. In cynomolgus monkeys, rozanolixizumab reduced IgG (maximum 75 to 90% by about day 10), was well tolerated, and did not increase risk of infection...
November 1, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29078982/topical-reformulation-of-valsartan-for-treatment-of-chronic-diabetic-wounds
#7
Peter Abadir, Sayed Hosseini, Mahya Faghih, Amir Ansari, Frank Lay, Barbara Smith, Aleksandra Beselman, Diep Vuong, Alan Berger, Jing Tian, David Rini, Kevin Keenahan, Joshua Budman, Tadashi Inagami, Neal Fedarko, Guy Marti, John Harmon, Jeremy Walston
Chronic wounds are among the most devastating and difficult to treat consequences of diabetes. Dysregulation of the skin renin-angiotensin system (RAS) is implicated in abnormal wound healing in diabetic and older adults. Given this, we sought to determine the effects of topical reformulations of the angiotensin type 1 receptor blockers (ARB) losartan and valsartan and the angiotensin-converting enzyme (ACE) inhibitor captopril on wound healing in diabetic and aged mice with further validation in older diabetic pigs...
October 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29077904/ufboot2-improving-the-ultrafast-bootstrap-approximation
#8
Diep Thi Hoang, Olga Chernomor, Arndt von Haeseler, Bui Quang Minh, Sy Vinh Le
The standard bootstrap (SBS), despite being computationally intensive, is widely used in maximum likelihood phylogenetic analyses. We recently proposed the ultrafast bootstrap approximation (UFBoot) to reduce computing time while achieving more unbiased branch supports than SBS under mild model violations. UFBoot has been steadily adopted as an efficient alternative to SBS and other bootstrap approaches.Here, we present UFBoot2, which substantially accelerates UFBoot and reduces the risk of overestimating branch supports due to polytomies or severe model violations...
October 25, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29077662/kratom-an-emerging-drug-of-abuse-a-case-report-of-overdose-and-management-of-withdrawal
#9
Jack Diep, David Tian Chin, Somdatta Gupta, Faraz Syed, Ming Xiong, Jianguo Cheng
Kratom is an herb indigenous to Southeast Asia with psychoactive opioid compounds, often used as a treatment for chronic pain or opiate withdrawal symptoms. It is legally and readily available via Internet sales and has been identified as an emerging drug of abuse in the United States. Kratom use has been associated with psychosis, seizures, and even death. At lower doses, kratom acts as a stimulant, while at higher doses, it produces analgesia and euphoria. Here, we describe the successful management of kratom overdose and withdrawal in a young man with negative toxicology screens...
October 26, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29071492/sensation-of-the-autologous-reconstructed-breast-improves-quality-of-life-a-pilot-study
#10
Anouk J M Cornelissen, Jop Beugels, Sander M J van Kuijk, Esther M Heuts, Shai M Rozen, Aldona J Spiegel, René R W J van der Hulst, Stefania M H Tuinder
PURPOSE: The number of breast cancer survivors continues to grow. Due to refinements in operating techniques, autologous breast reconstruction has become part of standard care. Impaired sensation remains a debilitating side effect with a significant impact on the quality of life. Microsurgical nerve coaptation of a sensory nerve has the potential to improve sensation of the reconstructed breast. This study investigates the effect of improved sensation of the reconstructed breast on the quality of life in breast cancer survivors...
October 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29068921/evidence-based-clinical-practice-guideline-autologous-breast-reconstruction-with-diep-or-pedicled-tram-abdominal-flaps
#11
COMPARATIVE STUDY
Bernard T Lee, Jayant P Agarwal, Jeffrey A Ascherman, Stephanie A Caterson, Diedra D Gray, Scott T Hollenbeck, Seema A Khan, Lauren D Loeding, Raman C Mahabir, Archibald S Miller, Galen Perdikis, Jaime S Schwartz, Beth A Sieling, Achilles Thoma, Judith A Wolfman, Jean L Wright
The American Society of Plastic Surgeons commissioned a multistakeholder Work Group to develop recommendations for autologous breast reconstruction with abdominal flaps. A systematic literature review was performed and a stringent appraisal process was used to rate the quality of relevant scientific research. The Work Group assigned to draft this guideline was unable to find evidence of superiority of one technique over the other (deep inferior epigastric perforator versus pedicled transverse rectus abdominis musculocutaneous flap) in autologous tissue reconstruction of the breast after mastectomy...
November 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29065527/factors-influencing-early-feeding-of-foods-and-drinks-containing-free-sugars-a-birth-cohort-study
#12
Diep H Ha, Loc G Do, Andrew John Spencer, William Murray Thomson, Rebecca K Golley, Andrew J Rugg-Gunn, Steven M Levy, Jane A Scott
Early feeding of free sugars to young children can increase the preference for sweetness and the risk of consuming a cariogenic diet high in free sugars later in life. This study aimed to investigate early life factors influencing early introduction of foods/drinks containing free sugars. Data from an ongoing population-based birth cohort study in Australia were used. Mothers of newborn children completed questionnaires at birth and subsequently at ages 3, 6, 12, and 24 months. The outcome was reported feeding (Yes/No) at age 6-9 months of common foods/drinks sources of free sugars (hereafter referred as foods/drinks with free sugars)...
October 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29060868/real-time-analysis-on-ensemble-svm-scores-to-reduce-p300-speller-intensification-time
#13
Kha Vo, Diep N Nguyen, Ha Hoang Kha, Eryk Dutkiewicz
In most Brain-Computer Interface systems, especially the P300-Speller, there must be a harmonized balance between the accuracy and the spelling time. One major drawback of the classical 36-choice P300-Speller is the slow rate of character elicitation. This paper aims to propose a real-time signal processing method to decrease the spelling time by exploiting the score margins of the ensemble Support Vector Machine classifiers during real-time P300-Speller flashes, rather than just getting the classifiers' highest scores...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29050873/comparing-the-sensation-of-common-donor-site-regions-for-autologous-breast-reconstruction-to-that-of-a-healthy-breast
#14
Anouk J M Cornelissen, Jop Beugels, Arno Lataster, Esther M Heuts, Shai M Rozen, Aldona J Spiegel, René R W J van der Hulst, Stefania M H Tuinder
INTRODUCTION: Autologous breast reconstruction has become the standard care for breast cancer patients. Although excellent cosmetic results can be achieved, most reconstructed breasts fail to regain normal sensation. Nerve coaptation of the flap has been suggested to improve sensation; the effect of the donor flap native sensory threshold on the degree of sensory restoration is yet to be determined. The aim of this study is to evaluate the differences in sensation between various potential donor site regions in comparison to the sensation of the healthy breast...
September 25, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29039287/strongyloides-stercoralis-seroprevalence-in-vietnam
#15
Nguyen Thi Ngoc Diep, Pham Quang Thai, Nghiem Nguyen Minh Trang, Julia Jäger, Annette Fox, Peter Horby, Hoang Vu Mai Phuong, Dang Duc Anh, LE Thi Quynh Mai, H Rogier VAN Doorn, Behzad Nadjm
Strongyloidiasis is a neglected tropical disease caused by the roundworm Strongyloides stercoralis affecting 30-100 million people worldwide. Many Southeast-Asian countries report a high prevalence of S. stercoralis infection, but there are little data from Vietnam. Here, we evaluated the seroprevalence of S. stercoralis related to geography, sex and age in Vietnam through serological testing of anonymized sera. Sera (n = 1710, 1340 adults and 270 children) from an anonymized age-stratified serum bank from four regions in Vietnam between 2012 and 2013 were tested using a commercial Strongyloides ratti immunoglobulin G ELISA...
October 17, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29019862/complications-and-patient-reported-outcomes-after-abdominal-based-breast-reconstruction-results-of-the-mastectomy-reconstruction-outcomes-consortium-mroc-study
#16
Jessica Erdmann-Sager, Edwin G Wilkins, Andrea L Pusic, Ji Qi, Jennifer B Hamill, Hyungjin Myra Kim, Gretchen E Guldbrandsen, Yoon S Chun
BACKGROUND: Abdominal flap reconstruction is the most popular form of autologous breast reconstruction. The current study compared complications and patient-reported outcomes (PROs) after pedicled transverse rectus abdominis myocutaneous (PTRAM), free TRAM (FTRAM), deep inferior epigastric perforator (DIEP), and superficial inferior epigastric artery (SIEA) flaps. METHODS: Patients having abdominal-based breast reconstruction at 11 centers were prospectively evaluated for abdominal donor-site and breast complications...
October 10, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29019861/the-lateral-thigh-perforator-ltp-flap-for-autologous-breast-reconstruction-a-prospective-analysis-of-138-flaps
#17
Stefania M H Tuinder, Jop Beugels, Arno Lataster, Michiel W de Haan, Andrzej Piatkowski, Michel Saint-Cyr, René R W J van der Hulst, Robert J Allen
BACKGROUND: The septocutaneous tensor fasciae latae (sc-TFL) or lateral thigh perforator (LTP) flap was previously introduced by our group as an alternative flap for autologous breast reconstruction when the abdomen is not suitable as a donor site. The aim of this study was to analyze our experience with the LTP flap and to present the surgical refinements that were introduced. METHODS: A prospective study was conducted of all LTP flap breast reconstructions performed since September 2012...
October 10, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28993252/h-d-exchange-mass-spectrometry-and-statistical-coupling-analysis-reveal-a-role-for-allostery-in-a-ferredoxin-dependent-bifurcating-transhydrogenase-catalytic-cycle
#18
Luke Berry, Saroj Poudel, Monika Tokmina-Lukaszewska, Daniel R Colman, Diep M N Nguyen, Gerrit J Schut, Michael W W Adams, John W Peters, Eric S Boyd, Brian Bothner
Recent investigations into ferredoxin-dependent transhydrogenases, a class of enzymes responsible for electron transport, have highlighted the biological importance of flavin-based electron bifurcation (FBEB). FBEB generates biomolecules with very low reduction potential by coupling the oxidation of an electron donor with intermediate potential to the reduction of high and low potential molecules. Bifurcating systems can generate biomolecules with very low reduction potentials, such as reduced ferredoxin (Fd), from species such as NADPH...
January 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28986422/the-arabidopsis-dna-methylome-is-stable-under-transgenerational-drought-stress
#19
Diep Ganguly, Peter Alexander Crisp, Steven R Eichten, Barry J Pogson
Improving the responsiveness, acclimation, and memory of plants to abiotic stress holds substantive potential for improving agriculture. An unresolved question is the involvement of chromatin marks in the memory of agriculturally-relevant stresses. Such potential has spurred numerous investigations yielding both promising and conflicting results. Consequently, it remains unclear to what extent robust stress-induced DNA methylation variation can underpin stress memory. Using a slow onset water deprivation treatment in Arabidopsis we investigated the malleability of the DNA methylome to drought stress within a generation and under repeated drought stress over five successive generations...
October 6, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28972286/foot-and-ankle-reconstruction-with-vertically-designed-deep-inferior-epigastric-perforator-flap
#20
Osman Akdag, Mehtap Karamese, Gokce Unal Yıldıran, Mustafa Sutcu, Zekeriya Tosun
INTRODUCTION: The deep inferior epigastric perforator (DIEP) flap is one of the most commonly utilized flaps of reconstructive surgery. Although the horizontal flap design is the most commonly used, this flap can be vertically designed to avoid drawbacks such as excessive tissue dissection, relatively reduced flap perfusion, and scarification of the contralateral flap opportunity. The aim of this report is to present our case series for foot and ankle reconstruction with vertical designed DIEP flap...
October 3, 2017: Microsurgery
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