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https://www.readbyqxmd.com/read/28515717/the-leaderless-bacteriocin-enterocin-k1-is-highly-potent-against-enterococcus-faecium-a-study-on-structure-target-spectrum-and-receptor
#1
Kirill V Ovchinnikov, Per Eugen Kristiansen, Daniel Straume, Marianne S Jensen, Tamara Aleksandrzak-Piekarczyk, Ingolf F Nes, Dzung B Diep
Enterocin K1 (EntK1), enterocin EJ97 (EntEJ97), and LsbB are three sequence related leaderless bacteriocins. Yet LsbB kills only lactococci while EntK1 and EntEJ97 target wider spectra with EntK1 being particularly active against Enterococcus faecium, including nosocomial multidrug resistant isolates. NMR study of EntK1 showed that it had a structure very similar to LsbB - both having an amphiphilic N-terminal α-helix and an unstructured C-terminus. The α-helix in EntK1 is, however, about 3-4 residues longer than that of LsbB...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28506461/mk2-phosphorylates-ripk1-to-prevent-tnf-induced-cell-death
#2
Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, Lucie Laurien, Chun Kim, Kunzah Jamal, Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke, Pascal Meier
TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α, and its downstream effector kinase MK2, thereby promoting transcription, mRNA stabilization, and translation of target genes. Here we show that TNF-induced activation of MK2 results in global RIPK1 phosphorylation. MK2 directly phosphorylates RIPK1 at residue S321, which inhibits its ability to bind FADD/caspase-8 and induce RIPK1-kinase-dependent apoptosis and necroptosis...
May 10, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28486409/direct-laser-writing-of-magneto-photonic-sub-microstructures-for-prospective-applications-in-biomedical-engineering
#3
Thi Huong Au, Duc Thien Trinh, Quang Cong Tong, Danh Bich Do, Dang Phu Nguyen, Manh-Huong Phan, Ngoc Diep Lai
We report on the fabrication of desired magneto-photonic devices by a low one-photon absorption (LOPA) direct laser writing (DLW) technique on a photocurable nanocomposite consisting of magnetite ( Fe 3 O 4 ) nanoparticles and a commercial SU-8 photoresist. The magnetic nanocomposite was synthesized by mixing Fe 3 O 4 nanoparticles with different kinds of SU-8 photoresists. We demonstrated that the degree of dispersion of Fe 3 O 4 nanoparticles in the nanocomposite depended on the concentration of Fe 3 O 4 nanoparticles, the viscosity of SU-8 resist, and the mixing time...
May 9, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28484925/impact-of-serum-her2-timp-1-and-caix-on-outcome-for-her2-%C3%A2-metastatic-breast-cancer-patients-cctg-ma-31-lapatinib-vs-trastuzumab
#4
Diep Ho, Jessica Huang, Judith-Anne W Chapman, Kim Leitzel, Suhail M Ali, Lois Shepherd, Wendy R Parulekar, Catherine E Ellis, Rocco J Crescnzo, Liting Zhu, Shakeel Virk, Dora Nomikos, Samuel Aparicio, Karen A Gelmon, Walter P Carney, Allan Lipton
BACKGROUND: The lapatinib-taxane combination led to shorter PFS than trastuzumab-taxane in HER2+ metastatic breast cancer. We investigated the prognostic and predictive effects of pretreatment serum HER2, CAIX, and TIMP-1. METHODS: MA.31 accrued 652 patients; 537 (82%) were centrally confirmed HER2+. Biomarkers were categorized for univariate and multivariable predictive investigations with a median cut-point, ULN cut-points (15 ng/ml for HER2; 506 pg/ml for CAIX; 454 pg/ml for TIMP-1), and custom cut-points (30 and 100 ng/ml for HER2)...
May 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28470029/diep-flap-breast-reconstruction-preserving-a-lumbar-peritoneal-shunt-tube
#5
Kentarou Ueki, Katsuhiro Yoshikawa, Tatsuki Enoshiri, Masahiro Tanji, Megumi Takeuchi, Shigehiko Suzuki
We herein report a case of immediate deep inferior epigastric perforator flap (DIEP flap) breast reconstruction surgery in a 50-year-old female patient with a lumbar peritoneal shunt tube. We performed DIEP flap reconstruction in the patient by withdrawing and subsequently reinserting the abdominal side of an implanted shunt tube.
2017: Case Reports in Plastic Surgery & Hand Surgery
https://www.readbyqxmd.com/read/28467300/tcf7l1-promotes-skin-tumorigenesis-independently-of-%C3%AE-catenin-through-induction-of-lcn2
#6
Amy T Ku, Timothy M Shaver, Ajay S Rao, Jeffrey M Howard, Christine N Rodriguez, Qi Miao, Gloria Garcia, Diep Le, Diane Yang, Malgorzata Borowiak, Daniel N Cohen, Vida Chitsazzadeh, Abdul H Diwan, Kenneth Y Tsai, Hoang Nguyen
The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. Here we document TCF7L1 upregulation in skin squamous cell carcinoma (SCC) and demonstrate that TCF7L1 overexpression increases tumor incidence, tumor multiplicity, and malignant progression in the chemically induced mouse model of skin SCC. Additionally, we show that downregulation of TCF7L1 and its paralogue TCF7L2 reduces tumor growth in a xenograft model of human skin SCC...
May 3, 2017: ELife
https://www.readbyqxmd.com/read/28466303/a-new-and-efficient-approach-for-construction-of-uridine-uracil-auxotrophic-mutants-in-the-filamentous-fungus-aspergillus-oryzae-using-agrobacterium-tumefaciens-mediated-transformation
#7
Khuyen Thi Nguyen, Quynh Ngoc Ho, Loc Thi Binh Xuan Do, Linh Thi Dam Mai, Duc-Ngoc Pham, Huyen Thi Thanh Tran, Diep Hong Le, Huy Quang Nguyen, Van-Tuan Tran
Aspergillus oryzae is a filamentous fungus widely used in food industry and as a microbial cell factory for recombinant protein production. Due to the inherent resistance of A. oryzae to common antifungal compounds, genetic transformation of this mold usually requires auxotrophic mutants. In this study, we show that Agrobacterium tumefaciens-mediated transformation (ATMT) method is very efficient for deletion of the pyrG gene in different Aspergillus oryzae wild-type strains to generate uridine/uracil auxotrophic mutants...
June 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28441010/instrumental-setup-for-simultaneous-total-and-speciation-analysis-of-volatile-arsenic-compounds-in-gas-and-liquefied-gas-samples
#8
Laura Freije-Carrelo, Mariella Moldovan, J Ignacio García Alonso, Thuy Diep Thanh Vo, Jorge Ruiz Encinar
Although analysis of metals and metalloids, such as arsenic, is widely spread in many different fields, their analysis in gas and liquefied gas samples is still a challenge. A new GC-ICP-MS set up has been developed for their simultaneous total and speciation analysis in gas and liquefied gas samples without the need of a preconcentration step. An arsine in nitrogen standard was used for optimization and evaluation of the system. Good linearity and detection limits in the very low ppt level for both total and speciation analyses were found...
May 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28438930/in-vitro-assessment-of-combined-polymyxin-b-and-minocycline-therapy-against-klebsiella-pneumoniae-carbapenemase-kpc-producing-k-pneumoniae
#9
Dennis Huang, Brenda Yu, John K Diep, Rajnikant Sharma, Michael Dudley, Keith S Kaye, Jason M Pogue, Cely Abboud Saad, Gauri Rao
The multi-drug resistance profiles of Klebsiella pneumoniae carbapenemase (KPC) producers have increased clinical polymyxin use. Combination therapy with polymyxins may improve treatment outcomes, but it is uncertain which combinations are most effective. Clinical successes have been reported with intravenous minocycline-based combination treatments for infections caused by carbapenemase-producing bacteria. The objective of this study was to evaluate the in vitro activity of polymyxin B and minocycline combination therapy against six KPC-2-producing K...
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28434811/predicting-and-planning-for-siea-flap-utilisation-in-breast-reconstruction-an-algorithm-combining-pre-operative-computed-tomography-analysis-and-intra-operative-angiosome-assessment
#10
Francis P Henry, Daniel P Butler, Simon H Wood, Navid Jallali
BACKGROUND: Low flap complication rates and excellent aesthetic outcomes are now commonplace in breast reconstruction. As a result, attention is now being focussed on minimising donor site morbidity. Despite its potential donor site advantages, the superficial inferior epigastric artery (SIEA) flap is often discounted, given concerns about the high flap failure rates. In this study, we present our experience of using the SIEA flap in breast reconstruction and provide an algorithm based on pre-operative computed tomography angiography (CTA) to aid pre-operative planning...
April 8, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28427105/optimizing-outcomes-in-free-flap-breast-reconstruction-in-the-community-hospitals-setting-a-stepwise-approach-to-diep-siea-flap-procedures-with-banking-a-hemiabdominal-flap
#11
Alberto Okada, Diego Daniel Pereira, Eduardo Montag, Marcelo Portocarrero, Carlos Felício, Eduardo Gustavo Arruda, Alexandre Fonseca, Rolf Gemperli, Alexandre Mendonça Munhoz
No abstract text is available yet for this article.
April 20, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/28416666/drebrin-restricts-rotavirus-entry-by-inhibiting-dynamin-mediated-endocytosis
#12
Bin Li, Siyuan Ding, Ningguo Feng, Nancie Mooney, Yaw Shin Ooi, Lili Ren, Jonathan Diep, Marcus R Kelly, Linda L Yasukawa, John T Patton, Hiroyuki Yamazaki, Tomoaki Shirao, Peter K Jackson, Harry B Greenberg
Despite the wide administration of several effective vaccines, rotavirus (RV) remains the single most important etiological agent of severe diarrhea in infants and young children worldwide, with an annual mortality of over 200,000 people. RV attachment and internalization into target cells is mediated by its outer capsid protein VP4. To better understand the molecular details of RV entry, we performed tandem affinity purification coupled with high-resolution mass spectrometry to map the host proteins that interact with VP4...
May 2, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28416116/activation-of-a-plant-nlr-complex-through-heteromeric-association-with-an-autoimmune-risk-variant-of-another-nlr
#13
Diep T N Tran, Eui-Hwan Chung, Anette Habring-Müller, Monika Demar, Rebecca Schwab, Jeffery L Dangl, Detlef Weigel, Eunyoung Chae
When independently evolved immune receptor variants meet in hybrid plants, they can activate immune signaling in the absence of non-self recognition. Such autoimmune risk alleles have recurrently evolved at the DANGEROUS MIX2 (DM2) nucleotide-binding domain and leucine-rich repeat (NLR)-encoding locus in A. thaliana. One of these activates signaling in the presence of a particular variant encoded at another NLR locus, DM1. We show that the risk variants of DM1 and DM2d NLRs signal through the same pathway that is activated when plant NLRs recognize non-self elicitors...
April 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28406946/cholera-returns-to-southern-vietnam-in-an-outbreak-associated-with-consuming-unsafe-water-through-iced-tea-a-matched-case-control-study
#14
Thuong V Nguyen, Quang D Pham, Quoc K Do, Tai T Diep, Hung C Phan, Thang V Ho, Hong T Do, Lan T Phan, Huu N Tran
BACKGROUND: After more than a decade of steadily declining notifications, the number of reported cholera cases has recently increased in Vietnam. We conducted a matched case-control study to investigate transmission of cholera during an outbreak in Ben Tre, southern Vietnam, and to explore the associated risk factors. METHODOLOGY/PRINCIPAL FINDINGS: Sixty of 71 diarrheal patients confirmed to be infected with cholera by culture and diagnosed between May 9 and August 3, 2010 in Ben Tre were consecutively recruited as case-patients...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28400923/significance-of-inferior-wall-ischemia-in-non-dominant-right-coronary-artery-anatomy
#15
Ali Osama Malik, Oliver Abela, Subodh Devabhaktuni, Arhama Aftab Malik, Gayle Allenback, Chowdhury H Ahsan, Sanjay Malhotra, Jimmy Diep
AIM: To investigate the relationship of inferior wall ischemia on myocardial perfusion imaging in patients with non-dominant right coronary artery anatomy. METHODS: This was a retrospective observational analysis of consecutive patients who presented to the emergency department with primary complaint of chest pain. Only patients who underwent single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) were included. Patients who showed a reversible defect on SPECT MPI and had coronary angiography during the same hospitalization was analyzed...
March 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28394885/mechanistic-insights-into-energy-conservation-by-flavin-based-electron-bifurcation
#16
Carolyn E Lubner, David P Jennings, David W Mulder, Gerrit J Schut, Oleg A Zadvornyy, John P Hoben, Monika Tokmina-Lukaszewska, Luke Berry, Diep M Nguyen, Gina L Lipscomb, Brian Bothner, Anne K Jones, Anne-Frances Miller, Paul W King, Michael W W Adams, John W Peters
The recently realized biochemical phenomenon of energy conservation through electron bifurcation provides biology with an elegant means to maximize utilization of metabolic energy. The mechanism of coordinated coupling of exergonic and endergonic oxidation-reduction reactions by a single enzyme complex has been elucidated through optical and paramagnetic spectroscopic studies revealing unprecedented features. Pairs of electrons are bifurcated over more than 1 volt of electrochemical potential by generating a low-potential, highly energetic, unstable flavin semiquinone and directing electron flow to an iron-sulfur cluster with a highly negative potential to overcome the barrier of the endergonic half reaction...
June 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28390953/pannexin-2-deficiency-sensitizes-pancreatic-%C3%AE-cells-to-cytokine-induced-apoptosis-in%C3%A2-vitro-and-impairs-glucose-tolerance-in%C3%A2-vivo
#17
Lukas A Berchtold, Michela Miani, Thi A Diep, Andreas N Madsen, Valentina Cigliola, Maikel Colli, Jelena M Krivokapic, Flemming Pociot, Decio L Eizirik, Paolo Meda, Birgitte Holst, Nils Billestrup, Joachim Størling
Pannexins (Panx's) are membrane proteins involved in a variety of biological processes, including cell death signaling and immune functions. The role and functions of Panx's in pancreatic β-cells remain to be clarified. Here, we show Panx1 and Panx2 expression in isolated islets, primary β-cells, and β-cell lines. The expression of Panx2, but not Panx1, was downregulated by interleukin-1β (IL-1β) plus interferon-γ (IFNγ), two pro-inflammatory cytokines suggested to contribute to β-cell demise in type 1 diabetes (T1D)...
April 5, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28386541/impact-of-5-amp-activated-protein-kinase-on-male-gonad-and-spermatozoa-functions
#18
REVIEW
Thi Mong Diep Nguyen
As we already know, the male reproductive system requires less energetic investment than the female one. Nevertheless, energy balance is an important feature for spermatozoa production in the testis and for spermatozoa properties after ejaculation. The 5'-AMP-activated protein kinase, AMPK, is a sensor of cell energy, that regulates many metabolic pathways and that has been recently shown to control spermatozoa quality and functions. It is indeed involved in the regulation of spermatozoa quality through its action on the proliferation of testicular somatic cells (Sertoli and Leydig), on spermatozoa motility and acrosome reaction...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28368859/the-prevalence-of-listeria-monocytogenes-and-staphylococcus-aureus-and-their-virulence-genes-in-bulk-tank-milk-in-kosovo
#19
Ibrahim Mehmeti, Hysen Bytyqi, Skender Muji, Ingolf F Nes, Dzung B Diep
INTRODUCTION: Milk is considered to be a healthy, nutritious food product. Microbiological quality is an important aspect in evaluating the quality of milk. METHODOLOGY: A total of 603 bulk tank milk samples from 221 farms distributed across ten different regions were collected for milk quality assessment. Quality was judged by total viable count, and the prevalence of two foodborne pathogens (Listeria monocytogenes and Staphylococcus aureus) by using selective media and 16S rRNA gene sequencing...
March 31, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28346508/most-women-recover-from-psychological-distress-after-postoperative-complications-following-implant-or-diep-flap-breast-reconstruction-a-prospective-long-term-follow-up-study
#20
Reinier Timman, Jessica P Gopie, J Nick Brinkman, Annelies Kleijne, Caroline Seynaeve, Marian B E Menke-Pluymers, Moniek M Ter Kuile, Aad Tibben, Marc A M Mureau
BACKGROUND: Substantial complication rates after postmastectomy breast reconstruction (BR) in breast cancer patients have been reported. Few studies have reported on the resulting psychological distress (PD) and satisfaction with the aesthetic result in relation to postoperative complications after completion of implant or DIEP flap BR. The present study investigated whether women were able to recover from complication related distress in the long term. METHODS: PD was prospectively measured using questionnaires regarding anxiety, depression and cancer distress...
2017: PloS One
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