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https://www.readbyqxmd.com/read/28615449/equilibrium-and-ultrafast-kinetic-studies-manipulating-electron-transfer-a-short-lived-flavin-semiquinone-is-not-sufficient-for-electron-bifurcation
#1
John P Hoben, Carolyn E Lubner, Michael W Ratzloff, Gerrit J Schut, Diep M N Nguyen, Karl W Hempel, Michael W W Adams, Paul W King, Anne-Frances Miller
Flavin-based electron transfer bifurcation is emerging as a fundamental and powerful mechanism for conservation and deployment of electrochemical energy in enzymatic systems. In this process, a pair of electrons is acquired at intermediate reduction potential (i.e. intermediate reducing power) and each electron is passed to a different acceptor, one with lower and the other with higher reducing power, leading to 'bifurcation'. It is believed that a strongly reducing semiquinone species is essential for this process, and it is expected that this species should be kinetically short-lived...
June 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28614316/rapid-direct-laser-writing-of-desired-plasmonic-nanostructures
#2
Quang Cong Tong, Mai Hoang Luong, Jacqueline Remmel, Minh Thanh Do, Dam Thuy Trang Nguyen, Ngoc Diep Lai
We demonstrate a direct way to realize arbitrary gold nanostructures via a local dewetting method. This technique was based on the optically induced local thermal effect at the focusing region of a direct laser writing (DLW) system employing a green continuous-wave laser. The local high temperature allowed the creation of gold nano-islands only at the focusing area of the optical system. By moving the focusing spot, this DLW method allowed us to "write" desired two-dimensional gold patterns with a feature size down to sub-lambda...
June 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28607850/interpositional-lateral-thoracic-vein-graft-for-diep-flap-salvage-in-setting-of-superficial-venous-system-dominance
#3
Manas Nigam, Michael V DeFazio, Maurice Y Nahabedian
No abstract text is available yet for this article.
May 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28606621/studying-the-blood-pressures-of-antegrade-and-retrograde-internal-mammary-vessels-do-they-really-work-as-recipient-vessels
#4
Yoko Katsuragi Tomioka, Hirokazu Uda, Kotaro Yoshimura, Ataru Sunaga, Hideaki Kamochi, Yasushi Sugawara
BACKGROUND: The proximal ends of internal mammary (IM) vessels are now the most common recipient vessels for breast reconstruction. On the other hand, bilateral deep inferior epigastric artery perforator (DIEP) flaps are often needed according to the territory and the volume required for reconstruction. The usefulness of retrograde IM vessels as second recipients has recently been reported, but there are very few quantitative studies on the hydrodynamics of the retrograde IM vessels. Because the flow is dependent on the pressure differential, the blood pressures of the antegrade IM artery (AIMA), antegrade IM vein (AIMV), retrograde IM artery (RIMA), retrograde IM vein (RIMV), and recirculated intraflap vein (FV) were investigated to solve this question and to confirm the reliability and usefulness of the retrograde IM vessels...
May 22, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28603521/novel-combined-immune-deficiency-and-radiation-sensitivity-blended-phenotype-in-an-adult-with-biallelic-variations-in-zap70-and-rnf168
#5
Ivan K Chinn, Robert P Sanders, Asbjørg Stray-Pedersen, Zeynep H Coban-Akdemir, Vy Hong-Diep Kim, Harjit Dadi, Chaim M Roifman, Troy Quigg, James R Lupski, Jordan S Orange, I Celine Hanson
With the advent of high-throughput genomic sequencing techniques, novel genetic etiologies are being uncovered for previously unexplained Mendelian phenotypes, and the underlying genetic architecture of disease is being unraveled. Although most of these "mendelizing" disease traits represent phenotypes caused by single-gene defects, a percentage of patients have blended phenotypes caused by pathogenic variants in multiple genes. We describe an adult patient with susceptibility to bacterial, herpesviral, and fungal infections...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28602265/diep-flap-for-breast-reconstruction-is%C3%A2-abdominal-fat-thickness-associated-with-post-operative-complications
#6
Ali Modarressi, Camillo Theo Müller, Xavier Montet, Eva Meia Rüegg, Brigitte Pittet-Cuénod
INTRODUCTION: Some surgeons consider a high body mass index (BMI) or important abdominal fat excess as contraindications for breast reconstruction with free deep inferior epigastric perforator (DIEP) flap. This study aimed to identify factors associated with post-operative complications by using this type of flap, with an emphasis on BMI and abdominal subcutaneous fat thickness. METHODS: A retrospective chart review of 105 consecutive patients who underwent DIEP flap breast reconstruction at our institution was performed to assess post-operative complications...
May 18, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28597837/-effectiveness-of-selective-alveolar-decortication-in-accelerating-orthodontic-treatment-a-systematic-review
#7
Victor Fau, Dany Diep, Gérard Bader, Damien Brézulier, Olivier Sorel
INTRODUCTION: The number of scientific publications on accelerating orthodontic treatment, and especially surgical alveolar corticotomies techniques, has grown exponentially over the years. The objective of this systematic literature review was to assess the effectiveness of these corticotomies basing on human studies. MATERIAL AND METHOD: The review was conducted from Medline and Web of Science Core Collection to identify prospective controlled clinical trials with duration of orthodontic treatment or the tooth movement rate for primary endpoint...
June 2017: L' Orthodontie Française
https://www.readbyqxmd.com/read/28592464/pharmacokinetic-changes-in-liver-failure-and-impact-on-drug-therapy
#8
Uyen Diep, Melissa Chudow, Katlynd M Sunjic
No abstract text is available yet for this article.
2017: AACN Advanced Critical Care
https://www.readbyqxmd.com/read/28591940/cost-analysis-of-postmastectomy-reconstruction-a-comparison-of-two-staged-implant-reconstruction-using-tissue-expander-and-acellular-dermal-matrix-with-abdominal-based-perforator-free-flaps
#9
Bao Ngoc N Tran, Ayotunde Fadayomi, Samuel J Lin, Dhruv Singhal, Bernard T Lee
BACKGROUND AND OBJECTIVES: Two staged tissue expander-implant with acellular dermal matrix (TE/I + ADM) and deep inferior epigastric perforator (DIEP) flap are the most common implant and autologous methods of reconstruction in the U.S. Implant-based techniques are disproportionally more popular, partially due to its presumed cost effectiveness. We performed a comprehensive cost analysis to compare TE/I + ADM and DIEP flap. METHODS: A comparative cost analysis of TE/I + ADM and DIEP flap was performed...
June 7, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28556780/theory-of-magnons-in-spin-systems-with-dzyaloshinskii-moriya-interaction
#10
El Hog Sahbi, Hung T Diep, Hen Puszkarski
We study in this paper magnetic properties of a system of quantum Heisenberg spins interacting with each other via a ferromagnetic exchange interaction $J$ and an in-plane Dzyaloshinskii-Moriya interaction $D$. The non-collinear ground state due to the competition between $J$ and $D$ is determined. We employ a self-consistent Green'function theory to calculate the spin-wave spectrum and the layer magnetizations at finite $T$ in two and three dimensions as well as in a thin film with surface effects. Analytical details and the validity of the method are shown and discussed...
May 30, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28552761/hematopoietic-stem-cell-transplantation-for-relb-deficiency
#11
Adi Ovadia, Yael Dinur Schejter, Eyal Grunebaum, Vy Hong-Diep Kim, Brenda Reid, Tal Schechter, Elena Pope, Chaim M Roifman
HSCT conditioning is tolerated well by patients with RelB deficiency and leads to immune reconstitution.
May 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28529778/crystal-structure-of-the-diglycidyl-ether-of-eugenol
#12
Jordan Vigier, Camille François, Sylvie Pourchet, Gilles Boni, Laurent Plasseraud, Vincent Placet, Stéphane Fontaine, Hélène Cattey
The diep-oxy monomer, C13H16O4 {DGE-Eu; systematic name: 2-[3-meth-oxy-4-(oxiran-2-ylmeth-oxy)benz-yl]oxirane}, was synthesized from eugenol by a three-step reaction. It consists of a 1,2,4-tris-ubstituted benzene ring substituted by diglycidyl ether, a meth-oxy group and a methyl-oxirane group. The three-membered oxirane rings are inclined to the benzene ring by 61.0 (3) and 27.9 (3)°. The methyl-ene C atom of one of the two terminal epoxide rings is positionally disordered [refined occupancy ratio = 0...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28528800/an-innovative-method-of-planning-and-displaying-flap-volume-in-diep-flap-breast-reconstructions
#13
S Hummelink, Arico C Verhulst, Thomas J J Maal, Yvonne L Hoogeveen, Leo J Schultze Kool, Dietmar J O Ulrich
BACKGROUND: Determining the ideal volume of the harvested flap to achieve symmetry in deep inferior epigastric artery perforator (DIEP) flap breast reconstructions is complex. With preoperative imaging techniques such as 3D stereophotogrammetry and computed tomography angiography (CTA) available nowadays, we can combine information to preoperatively plan the optimal flap volume to be harvested. In this proof-of-concept, we investigated whether projection of a virtual flap planning onto the patient's abdomen using a projection method could result in harvesting the correct flap volume...
April 23, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28515717/the-leaderless-bacteriocin-enterocin-k1-is-highly-potent-against-enterococcus-faecium-a-study-on-structure-target-spectrum-and-receptor
#14
Kirill V Ovchinnikov, Per Eugen Kristiansen, Daniel Straume, Marianne S Jensen, Tamara Aleksandrzak-Piekarczyk, Ingolf F Nes, Dzung B Diep
Enterocin K1 (EntK1), enterocin EJ97 (EntEJ97), and LsbB are three sequence related leaderless bacteriocins. Yet LsbB kills only lactococci while EntK1 and EntEJ97 target wider spectra with EntK1 being particularly active against Enterococcus faecium, including nosocomial multidrug resistant isolates. NMR study of EntK1 showed that it had a structure very similar to LsbB - both having an amphiphilic N-terminal α-helix and an unstructured C-terminus. The α-helix in EntK1 is, however, about 3-4 residues longer than that of LsbB...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28506461/mk2-phosphorylates-ripk1-to-prevent-tnf-induced-cell-death
#15
Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, Lucie Laurien, Chun Kim, Kunzah Jamal, Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke, Pascal Meier
TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α, and its downstream effector kinase MK2, thereby promoting transcription, mRNA stabilization, and translation of target genes. Here we show that TNF-induced activation of MK2 results in global RIPK1 phosphorylation. MK2 directly phosphorylates RIPK1 at residue S321, which inhibits its ability to bind FADD/caspase-8 and induce RIPK1-kinase-dependent apoptosis and necroptosis...
June 1, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28486409/direct-laser-writing-of-magneto-photonic-sub-microstructures-for-prospective-applications-in-biomedical-engineering
#16
Thi Huong Au, Duc Thien Trinh, Quang Cong Tong, Danh Bich Do, Dang Phu Nguyen, Manh-Huong Phan, Ngoc Diep Lai
We report on the fabrication of desired magneto-photonic devices by a low one-photon absorption (LOPA) direct laser writing (DLW) technique on a photocurable nanocomposite consisting of magnetite ( Fe 3 O 4 ) nanoparticles and a commercial SU-8 photoresist. The magnetic nanocomposite was synthesized by mixing Fe 3 O 4 nanoparticles with different kinds of SU-8 photoresists. We demonstrated that the degree of dispersion of Fe 3 O 4 nanoparticles in the nanocomposite depended on the concentration of Fe 3 O 4 nanoparticles, the viscosity of SU-8 resist, and the mixing time...
May 9, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28484925/impact-of-serum-her2-timp-1-and-caix-on-outcome-for-her2-%C3%A2-metastatic-breast-cancer-patients-cctg-ma-31-lapatinib-vs-trastuzumab
#17
Diep Ho, Jessica Huang, Judith-Anne W Chapman, Kim Leitzel, Suhail M Ali, Lois Shepherd, Wendy R Parulekar, Catherine E Ellis, Rocco J Crescnzo, Liting Zhu, Shakeel Virk, Dora Nomikos, Samuel Aparicio, Karen A Gelmon, Walter P Carney, Allan Lipton
BACKGROUND: The lapatinib-taxane combination led to shorter PFS than trastuzumab-taxane in HER2+ metastatic breast cancer. We investigated the prognostic and predictive effects of pretreatment serum HER2, CAIX, and TIMP-1. METHODS: MA.31 accrued 652 patients; 537 (82%) were centrally confirmed HER2+. Biomarkers were categorized for univariate and multivariable predictive investigations with a median cut-point, ULN cut-points (15 ng/ml for HER2; 506 pg/ml for CAIX; 454 pg/ml for TIMP-1), and custom cut-points (30 and 100 ng/ml for HER2)...
May 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28470029/diep-flap-breast-reconstruction-preserving-a-lumbar-peritoneal-shunt-tube
#18
Kentarou Ueki, Katsuhiro Yoshikawa, Tatsuki Enoshiri, Masahiro Tanji, Megumi Takeuchi, Shigehiko Suzuki
We herein report a case of immediate deep inferior epigastric perforator flap (DIEP flap) breast reconstruction surgery in a 50-year-old female patient with a lumbar peritoneal shunt tube. We performed DIEP flap reconstruction in the patient by withdrawing and subsequently reinserting the abdominal side of an implanted shunt tube.
2017: Case Reports in Plastic Surgery & Hand Surgery
https://www.readbyqxmd.com/read/28467300/tcf7l1-promotes-skin-tumorigenesis-independently-of-%C3%AE-catenin-through-induction-of-lcn2
#19
Amy T Ku, Timothy M Shaver, Ajay S Rao, Jeffrey M Howard, Christine N Rodriguez, Qi Miao, Gloria Garcia, Diep Le, Diane Yang, Malgorzata Borowiak, Daniel N Cohen, Vida Chitsazzadeh, Abdul H Diwan, Kenneth Y Tsai, Hoang Nguyen
The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. Here we document TCF7L1 upregulation in skin squamous cell carcinoma (SCC) and demonstrate that TCF7L1 overexpression increases tumor incidence, tumor multiplicity, and malignant progression in the chemically induced mouse model of skin SCC. Additionally, we show that downregulation of TCF7L1 and its paralogue TCF7L2 reduces tumor growth in a xenograft model of human skin SCC...
May 3, 2017: ELife
https://www.readbyqxmd.com/read/28466303/a-new-and-efficient-approach-for-construction-of-uridine-uracil-auxotrophic-mutants-in-the-filamentous-fungus-aspergillus-oryzae-using-agrobacterium-tumefaciens-mediated-transformation
#20
Khuyen Thi Nguyen, Quynh Ngoc Ho, Loc Thi Binh Xuan Do, Linh Thi Dam Mai, Duc-Ngoc Pham, Huyen Thi Thanh Tran, Diep Hong Le, Huy Quang Nguyen, Van-Tuan Tran
Aspergillus oryzae is a filamentous fungus widely used in food industry and as a microbial cell factory for recombinant protein production. Due to the inherent resistance of A. oryzae to common antifungal compounds, genetic transformation of this mold usually requires auxotrophic mutants. In this study, we show that Agrobacterium tumefaciens-mediated transformation (ATMT) method is very efficient for deletion of the pyrG gene in different Aspergillus oryzae wild-type strains to generate uridine/uracil auxotrophic mutants...
June 2017: World Journal of Microbiology & Biotechnology
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