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https://www.readbyqxmd.com/read/29325422/outcomes-in-deep-inferior-epigastric-perforator-flap-and-implant-based-reconstruction-does-age-really-matter
#1
Lauren V Kuykendall, Angie Zhang, Bugra Tugertimur, Sara Bijan, Corin Agoris, Ambuj Kumar, Deniz Dayicioglu
Despite the growing elderly population, there is limited research specific to this demographic concerning breast reconstruction (BR). Lack of evidence-based BR recommendations in older populations may contribute to misconceptions and subsequent underutilization of BR, especially autologous BR. Patients who received either deep inferior epigastric perforator (DIEP) flap BR or tissue expander/implant (TE/I) BR by a single surgeon between July 2011 and July 2015 were surveyed postoperatively by using the psychometrically validated BREAST-Q questionnaire to determine patient satisfaction...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29322095/low-threshold-parametric-oscillation-in-organically-modified-microcavities
#2
Xiaoqin Shen, Rigoberto Castro Beltran, Vinh M Diep, Soheil Soltani, Andrea M Armani
Coherent frequency generators are an enabling platform in basic science and applied technology. Originally reliant on high-power lasers, recently comb generation has been demonstrated in ultrahigh-Q microcavities. The large circulating intensity within the cavity results in strong light-matter interaction, giving rise to Kerr parametric oscillations for comb generation. However, the comb generation threshold is limited by competing nonlinear effects within the cavity material and low intrinsic material Kerr coefficients...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29315799/preserving-a-patent-diep-pedicle-to-facilitate-salvage-breast-reconstruction-with-a-second-free-flap-a-case-report
#3
Dimitris Reissis, Daniel P Butler, Francis P Henry, Simon H Wood
Surgeons performing free flap breast reconstruction need to have a range of techniques in their armamentarium to successfully salvage cases of flap failure. We present a case of 47-year-old patient who suffered near-total right breast deep inferior epigastric perforator (DIEP) flap failure 3 days post-bilateral immediate breast reconstruction with DIEP flaps. At debridement, the DIEP pedicle was noted to be patent with preserved perfusion to a small segment of tissue around the origin of the pedicle. This tissue and the DIEP pedicle itself were therefore preserved to facilitate subsequent breast reconstruction using stacked transverse upper gracilis flaps anastomosed end-to-end to the original DIEP pedicle...
January 8, 2018: Microsurgery
https://www.readbyqxmd.com/read/29302489/enhancing-breast-projection-in-autologous-reconstruction-using-the-st-andrew-s-coning-technique-and-3d-volumetric-analysis
#4
Michael P Chae, Warren Matthew Rozen, Nakul Gamanlal Patel, David J Hunter-Smith, Venkat Ramakrishnan
Background: An increasing number of women undergo mastectomy for breast cancer and post-mastectomy autologous breast reconstruction has been shown to significantly improve the psychosexual wellbeing of the patients. A goal of treatment is to achieve symmetry and projection to match the native breast, and/or the contralateral breast in the case of a unilateral reconstruction. Autologous reconstruction, particularly with the deep inferior epigastric artery perforator (DIEP) flap, is particularly advantageous as it can be manipulated to mimic the shape and turgor of the native breast...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29302477/concordance-between-preoperative-computed-tomography-angiographic-mapping-and-intraoperative-perforator-selection-for-deep-inferior-epigastric-artery-perforator-flap-breast-reconstructions
#5
Vivian B Boer, Jan J van Wingerden, Carolien F Wever, Joost J Kardux, Michiel R Beets, Hester J van der Zaag-Loonen, Willem J Theuvenet
Background: Preoperative imaging for perforator identification prior to a deep inferior epigastric artery perforator (DIEP) flap elevation for breast reconstruction has many advantages. Currently, computed tomography (CT) angiography provides good visualization of the perforators and their course, and is thus the imaging technique of choice. The primary aim of this study was to determine the concordance between the perforators identified preoperatively and the perforators ultimately selected intraoperatively, with a standardized protocol, in a single institution...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29301944/y-chromosome-lineage-determines-cardiovascular-organ-t-cell-infiltration-in-the-stroke-prone-spontaneously-hypertensive-rat
#6
Shanzana I Khan, Karen L Andrews, Kristy L Jackson, Basimah Memon, Ann-Maree Jefferis, Man K S Lee, Henry Diep, Zihui Wei, Grant R Drummond, Geoffrey A Head, Garry L Jennings, Andrew J Murphy, Antony Vinh, Amanda K Sampson, Jaye P F Chin-Dusting
The essential role of the Y chromosome in male sex determination has largely overshadowed the possibility that it may exert other biologic roles. Here, we show that Y-chromosome lineage is a strong determinant of perivascular and renal T-cell infiltration in the stroke-prone spontaneously hypertensive rat, which, in turn, may influence vascular function and blood pressure (BP). We also show, for the first time to our knowledge, that augmented perivascular T-cell levels can directly instigate vascular dysfunction, and that the production of reactive oxygen species that stimulate cyclo-oxygenase underlies this...
January 4, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29289500/perforator-mapping-reduces-the-operative-time-of-diep-flap-breast-reconstruction-a-systematic-review-and-meta-analysis-of-preoperative-ultrasound-computed-tomography-and-magnetic-resonance-angiography
#7
REVIEW
Ryckie G Wade, James Watford, Justin C R Wormald, Russell J Bramhall, Andrea Figus
BACKGROUND: Prior to DIEP flap breast reconstruction, mapping the perforators of the lower abdominal wall using ultrasound, computed tomography angiography (CTA) or magnetic resonance angiography (MRA) reduces the risk of flap failure. This review aimed to investigate the additional potential benefit of a reduction in operating time. METHODS: We systematically searched the literature for studies concerning adult women undergoing DIEP flap breast reconstruction, which directly compared the operating times and adverse outcomes for those with and without preoperative perforator mapping by ultrasound, CTA or MRA...
December 12, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29285789/intraoperative-objective-evaluation-of-venous-congestion-in-deep-epigastric-artery-perforator-flap-breast-reconstruction-a-pilot-study
#8
Shinsuke Akita, Yoshihisa Yamaji, Hideki Tokumoto, Yoshitaro Sasahara, Takafumi Tezuka, Yoshitaka Kubota, Motone Kuriyama, Nobuyuki Mitsukawa
BACKGROUND: In a deep epigastric artery perforator (DIEP) flap breast reconstruction, the necessity of additional anastomosis of the superficial inferior epigastric vein (SIEV) should be determined intraoperatively. The purpose of this pilot study is to propose a method to detect venous congestion intraoperatively using the blood glucose measurement index (BGMI). METHODS: In 70 DIEP flaps of 67 patients for breast reconstruction, the ratio of blood glucose content in the flap to systemic blood glucose (BGMI) was measured immediately after wound closure...
December 29, 2017: Microsurgery
https://www.readbyqxmd.com/read/29227815/meta-analysis-of-flap-perfusion-and-donor-site-complications-for-breast-reconstruction-using-pedicled-versus-free-tram-and-diep-flaps
#9
REVIEW
Woonhyeok Jeong, Seongwon Lee, Junhyung Kim
OBJECTIVES: The transverse rectus abdominis musculocutaneous (TRAM) flap is an important option for breast reconstruction. Several studies have recently evaluated whether a greater number of complications result from the use of pedicled TRAM (pTRAM) flaps versus either free TRAM (fTRAM) flaps or deep inferior epigastric artery perforator (DIEP) flaps. To clarify the evidence regarding this issue, we performed an objective meta-analysis of published studies. MATERIALS AND METHODS: A literature search of articles published between January 1, 1990, to January 1, 2017 was performed using the PubMed, EMBASE, Scopus, and Cochrane databases...
December 8, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29224154/large-scale-targeted-dna-methylation-analysis-using-bisulfite-padlock-probes
#10
Dinh Diep, Nongluk Plongthongkum, Kun Zhang
Bisulfite padlock probes (BSPP) are a method for the targeted quantification of DNA methylation in mammalian genomes. They can simultaneously characterize the level of methylcytosine modification in a large number of targeted regions at single-base resolution. A major advantage of BSPP is that it allows the flexible capture of an arbitrary subset of genomic regions (hundreds to hundreds of thousands of genomic loci) in single-tube reactions. Large number of samples can be processed efficiently and converted into multiplexed sequencing libraries with only three enzymatic steps, without the conventional library preparation procedures...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29221853/venous-thromboembolism-events-after-breast-reconstructions-with-diep-free-flaps-in-192-consecutive-case
#11
A Modarressi, A-V Schettini, E M Rüegg, B Pittet-Cuénod
BACKGROUND: Patient candidates for breast reconstruction with free deep inferior epigastric perforator flap (DIEP) may present several risk factors for venous thromboembolism (VTE). Risk identification is essential for appropriate VTE prophylaxis measures to be put in place. This study aims to investigate VTE incidence after DIEP flap breast reconstruction and to assess the accuracy of the Caprini Risk Assessment Model (RAM), which is the unique score validated to assess the VTE risk for plastic surgery procedures and identify patients at high VTE risk...
December 5, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29212122/levels-of-circulating-intermediate-monocytes-decrease-after-aortic-valve-replacement-in-patients-with-severe-aortic-stenosis
#12
Bernd Hewing, Rena Ellerbroek, Sebastian Chi-Diep Au, Verena Stangl, Henryk Dreger, Michael Laule, Herko Grubitzsch, Fabian Knebel, Gert Baumann, Antje Ludwig, Karl Stangl
No abstract text is available yet for this article.
December 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29203494/polymyxin-b-and-zti-01-fosfomycin-for-injection-against-kpc-producing-klebsiella-pneumoniae-evaluation-of-activity-and-emergence-of-resistance
#13
John K Diep, Rajnikant Sharma, Evelyn J Ellis-Grosse, Cely S Abboud, Gauri G Rao
ZTI-01 (fosfomycin for injection) is a broad spectrum antibiotic with a novel mechanism of action and is currently under development in the USA for treatment of complicated urinary tract infections. Globally, fosfomycin and polymyxin B are increasingly being used to treat multi-drug resistant Gram-negative infections. The objectives were to evaluate the pharmacodynamic activity of polymyxin B and fosfomycin alone and in combination against KPC-producing K. pneumoniae and to assess the rate and extent of emergence of resistance to different antibiotic regimens...
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29199268/a-rare-case-of-giant-basal-cell-carcinoma-of-the-abdominal-wall-excision-and-immediate-reconstruction-with-a-pedicled-deep-inferior-epigastric-artery-perforator-diep-flap
#14
Sara Di Lorenzo, Giovanni Zabbia, Bartolo Corradino, Massimiliano Tripoli, Roberto Pirrello, Adriana Cordova
BACKGROUND Basal cell carcinoma (BCC) greater than 5 cm in diameter is called giant basal cell carcinoma (GBCC), or super giant basal cell carcinoma if it has a diameter larger than 20 cm. Giant BCC only accounts for 0.5% of BCCs and super giant BCC is exceedingly rare. On account of their rarity, there are no established guidelines for GBCC treatment. CASE REPORT We describe a peculiar case of an 82-year-old woman with a GBCC carcinoma of the lower abdominal wall. The tumor was surgically removed with ipsilateral inguinal lymph nodes and the abdominal wall was reconstructed immediately with a pedicled deep inferior epigastric artery perforator (DIEP) flap...
December 4, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29193255/evaluation-of-the-single-medial-circummuscular-perforator-diep-flap-outcomes-and-comparison-to-traditional-transmuscular-single-perforator-flap
#15
Jessica F Rose, Dmitry Zavlin, Amanda E Garrett, Vishwanath Chegireddy, Warren A Ellsworth
INTRODUCTION: Successful breast reconstruction using deep inferior epigastric perforator (DIEP) flaps depends on optimal perforator choice. Circummuscular wraparound medial perforators allow for no rectus dissection and minimal fascial incisions, often presenting as an ideal option. The aim of our study is to evaluate outcomes of the single medial wraparound perforator flap in comparison to more traditional transmuscular single-perforator DIEP flaps. PATIENTS AND METHODS: A retrospective chart review was conducted of all DIEP flaps performed by the senior author from 2011 to 2016, yielding 269 flaps on 157 patients...
November 29, 2017: Microsurgery
https://www.readbyqxmd.com/read/29193249/turbocharged-bilateral-pedicled-diep-flap-for-reconstruction-of-thigh-defect-without-recipient-vessels-a-case-report
#16
Manuel Fernández Garrido, Nicolás Pereira, Susana López Fernández, Carmen Vega, Jaume Masià
Reconstruction of thigh defects is usually straightforward, but in cases of poor soft tissue quality, free flap reconstruction is not possible due to the absence of recipient vessels. The turbocharge technique may increase the viable, vascularized area of a flap. In this report we present a case of the use of a turbocharged bilateral pedicled DIEP flap for reconstruction of thigh defect without recipient vessels. A 29-year-old woman who underwent neoadjuvant chemotherapy plus radiation therapy for a leiomyosarcoma on the left thigh...
November 29, 2017: Microsurgery
https://www.readbyqxmd.com/read/29184728/diep-flap-breast-reconstruction-in-patients-with-breast-ptosis-2-stage-reconstruction-using-3-dimensional-surface-imaging-and-a-printed-mold
#17
Koichi Tomita, Kenji Yano, Mifue Taminato, Michiko Nomori, Ko Hosokawa
Background: Autologous breast reconstruction can be performed for breasts with ptosis to a certain extent, but if patients desire to correct ptosis, mastopexy of the contralateral breast is indicated. However, accurate prediction of post-mastopexy breast shape is difficult to make, and symmetrical breast reconstruction requires certain experience. We have previously reported the use of three-dimensional (3D) imaging and printing technologies in deep inferior epigastric artery perforator (DIEP) flap breast reconstruction...
October 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29176425/reply-medial-row-perforators-are-associated-with-higher-rates-of-fat-necrosis-in-bilateral-diep-flap-breast-reconstruction
#18
Parisa Kamali, Michelle Lee, Bernard T Lee
No abstract text is available yet for this article.
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29176414/prospective-double-blind-evaluation-of-umbilicoplasty-techniques-using-conventional-and-crowdsourcing-methods
#19
RANDOMIZED CONTROLLED TRIAL
Charlotte L van Veldhuisen, Parisa Kamali, Winona Wu, Babette E Becherer, Hani H Sinno, Azra A Ashraf, Ahmed M S Ibrahim, Adam Tobias, Bernard T Lee, Samuel J Lin
BACKGROUND: Umbilical reconstruction is an important component of deep inferior epigastric perforator (DIEP) flap breast reconstruction. This study evaluated the aesthetics of three different umbilical reconstruction techniques during DIEP flap breast reconstruction. METHODS: From January to April of 2013, a total of 29 consecutive patients undergoing DIEP flap breast reconstruction were randomized intraoperatively to receive one of three umbilicoplasty types: a diamond, an oval, or an inverted V incision...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29175534/a-highly-efficient-agrobacterium-tumefaciens-mediated-transformation-system-for-the-postharvest-pathogen-penicillium-digitatum-using-dsred-and-gfp-to-visualize-citrus-host-colonization
#20
Tao Xuan Vu, Tho Tien Ngo, Linh Thi Dam Mai, Tri-Thuc Bui, Diep Hong Le, Ha Thi Viet Bui, Huy Quang Nguyen, Binh Xuan Ngo, Van-Tuan Tran
Penicillium digitatum is a major postharvest pathogen of citrus crops. This fungus broadly spreads worldwide and causes green mold disease, which results in severe losses for citrus production. Understanding of the citrus infection by P. digitatum may help develop effective strategies for controlling this pathogen. In this study, we have characterized a virulent strain of P. digitatum isolated in Vietnam and established a highly efficient Agrobacterium tumefaciens-mediated transformation (ATMT) system for this fungal strain with two newly constructed binary vectors...
November 23, 2017: Journal of Microbiological Methods
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