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https://www.readbyqxmd.com/read/27906762/complications-in-postmastectomy-breast-reconstruction-one-year-outcomes-of-the-mastectomy-reconstruction-outcomes-consortium-mroc-study
#1
Edwin G Wilkins, Jennifer B Hamill, Hyungjin M Kim, John Y Kim, Richard J Greco, Ji Qi, Andrea L Pusic
OBJECTIVE: In postmastectomy reconstruction, procedure choice is heavily influenced by the relative risks of the various options. This study sought to evaluate complications in a large, multicenter patient population. SUMMARY OF BACKGROUND DATA: Previous studies have reported widely varying complication rates, but have been limited by their single center designs and inadequate controlling for confounders in their analyses. METHODS: Eleven sites enrolled women undergoing first time, immediate, or delayed reconstruction following mastectomy for cancer treatment or prophylaxis...
November 30, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27894571/pre-expanded-deep-inferior-epigastric-perforator-flap
#2
REVIEW
Sharon E Monsivais, Nicholas D Webster, Stacy Wong, Michel H Saint-Cyr
The deep inferior epigastric perforator (DIEP) flap can be used to cover large defects of the proximal lower extremity, abdominal wall, perineum, vulva, and buttock. Pre-expanding DIEP flaps cause a possible delay phenomenon improving vascularity, decrease donor site morbidity, and increase the area that can be covered. Pre-expansion requires staged procedures, has risk of extrusion and infection, causes temporary contour deformity during the expansion process, and requires a longer course. Pre-expanded DIEP flaps can be a useful flap with proper patient selection and planning...
January 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27893463/inhibition-of-the-gas6-axl-pathway-augments-the-efficacy-of-chemotherapies
#3
Mihalis S Kariolis, Yu Rebecca Miao, Anh Diep, Shannon E Nash, Monica M Olcina, Dadi Jiang, Douglas S Jones, Shiven Kapur, Irimpan I Mathews, Albert C Koong, Erinn B Rankin, Jennifer R Cochran, Amato J Giaccia
The AXL receptor and its activating ligand, growth arrest-specific 6 (GAS6), are important drivers of metastasis and therapeutic resistance in human cancers. Given the critical roles that GAS6 and AXL play in refractory disease, this signaling axis represents an attractive target for therapeutic intervention. However, the strong picomolar binding affinity between GAS6 and AXL and the promiscuity of small molecule inhibitors represent important challenges faced by current anti-AXL therapeutics. Here, we have addressed these obstacles by engineering a second-generation, high-affinity AXL decoy receptor with an apparent affinity of 93 femtomolar to GAS6...
November 28, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27885675/intratissue-lymphovenous-communications-in-the-mechanism-of-action-of-vascularized-lymph-node-transfer
#4
María Miranda Garcés, Gemma Pons, Rosa Mirapeix, Jaume Masià
BACKGROUND AND OBJECTIVES: Vascularized lymph node transfer (VLNT) as a surgical treatment for cancer-related lymphedema has shown beneficial effects. The mechanism of action of this procedure involves lymphangiogenesis and lymphovenous communications (LVC) within the lymph nodes. We propose intratissue LVC as an additional element responsible for drainage of lymph to blood in the flap and examine this hypothesis in the current study. METHODS: This prospective study determined the passage of lymph to the venous system via intratissue LVC in 26 free flaps used for breast reconstruction...
November 25, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27872078/polymyxin-b-in-combination-with-rifampin-and-meropenem-against-polymyxin-b-resistant-kpc-producing-klebsiella-pneumoniae
#5
John Diep, David M Jacobs, Rajnikant Sharma, Jenna Covelli, Dana R Bowers, Thomas A Russo, Gauri G Rao
Safe and effective therapies are urgently needed to treat polymyxin-resistant KPC-producing K. pneumoniae and suppress the emergence of resistance. We investigated the pharmacodynamics of polymyxin B, rifampin, and meropenem alone and as polymyxin B-based double and triple combinations against KPC-producing K. pneumoniae The rate and extent of killing with polymyxin B (1-128mg/L), rifampin (2-16mg/L), and meropenem (10-120mg/L) were evaluated against polymyxin B-susceptible (PB(S)) and -resistant (PB(R)) clinical isolates using 48h static time-kills...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27802196/prognostic-factors-for-survival-in-advanced-appendiceal-cancers
#6
Fatima Khan, Rachel I Vogel, Gustave K Diep, Todd M Tuttle, Emil Lou
BACKGROUND: Appendiceal cancer is a rare malignancy. The optimal pathologic classification and prognostic factors for survival and treatment strategies remain poorly understood. OBJECTIVE: The aim of this retrospective cohort study was to determine prognostic factors, including markers of systemic inflammation, for survival in a cohort of patients with advanced appendiceal adenocarcinomas. METHODS: The study included patients with advanced appendiceal carcinoma that were treated between January 2006 and June 2012...
September 30, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27801370/antimicrobial-resistance-levels-amongst-staphylococci-isolated-from-clinical-cases-of-bovine-mastitis-in-kosovo
#7
Ibrahim Mehmeti, Behlul Behluli, Mergim Mestani, Arsim Ademi, Ingolf F Nes, Dzung B Diep
INTRODUCTION: Mastitis is one of the most frequent and costly disease in cattle. We studied milk samples from cattle with mastitis from farms in Kosovo to identify mastitis-causing pathogens and possible effective antibiotics. Our ultimate goal is to help implement adequate antibiotic management and treatment practices in Kosovo METHODOLOGY: A total of 152 milk samples were collected from cows with clinical mastitis from different farms in Kosovo. After identification of microorganisms, antibiotic susceptibility and the occurrence of enterotoxins was investigated...
October 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27798949/impact-of-time-interval-between-radiation-and-free-autologous-breast-reconstruction
#8
Aaron B Mull, Ali A Qureshi, Ema Zubovic, Yuan J Rao, Imran Zoberi, Ketan Sharma, Terence M Myckatyn
BACKGROUND: To evaluate whether the timing of surgery after radiation in autologous breast reconstruction affects major complications. METHODS: We performed a retrospective review of 454 free flaps (331 patients) for breast reconstruction at a single institution from 2003 to 2014. Charts were reviewed for age, BMI, laterality, flap type (TRAM, msTRAM, DIEP), surgeon, donor vessels (IMA, TD), chemotherapy, smoking, diabetes, hypertension, DVT, venous anastomoses, vein size, and time from radiation (none, < 12 months, or ≥ 12 months)...
October 31, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27795418/vietnamese-influenza-a-viruses-of-swine-between-2010-and-2015-multiple-introductions-of-a-h1n1-pdm09-viruses-into-the-pig-population-and-diversifying-genetic-constellations-of-enzootic-iav-s
#9
Nobuhiro Takemae, Michiyo Harada, Phuong Thanh Nguyen, Tung Nguyen, Tien Ngoc Nguyen, Thanh Long To, Tho Dang Nguyen, Vu Phong Pham, Vu Tri Le, Hoa Thi Do, Hung Van Vo, Quang Vinh Tin Le, Tan Minh Tran, Thanh Duy Nguyen, Phuong Duy Thai, Dang Hoang Nguyen, Anh Quynh Thi Le, Diep Thi Nguyen, Yuko Uchida, Takehiko Saito
: Active surveillance of influenza A viruses of swine (IAV-S) involving 262 farms and 10 slaughterhouses in seven provinces in northern and southern Vietnam from 2010 to 2015 yielded 388 isolates from 32 farms; these viruses were classified into H1N1, H1N2, and H3N2 subtypes. Whole-genome sequencing followed by phylogenetic analysis revealed that the isolates represented 15 genotypes, according to genetic constellation of the eight segments. All of the H1N1 viruses were entirely A(H1N1)pdm09 viruses, whereas all of the H1N2 and H3N2 viruses were reassortants among 5 distinct ancestral viruses: H1 and H3 triple-reassortant (TR) IAV-S that originated from North America and pre-2009 human seasonal H1, human seasonal H3N2, and A(H1N1)pdm09 viruses...
October 19, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27782983/techniques-and-perforator-selection-in-single-dominant-diep-flap-breast-reconstruction-algorithmic-approach-to-maximize-efficiency-and-safety
#10
Anita T Mohan, Lin Zhu, Zhen Wang, Aparna Vijayasekaran, Michel Saint-Cyr
BACKGROUND: Perforator selection is critical to deep inferior epigastric perforator (DIEP) flap harvest. Commitment to a single perforator has the potential benefit of a simpler dissection, but may increase fat necrosis or perfusion-related complications compared with multiple perforator harvest. METHODS: A 3-year retrospective study was carried out of all patients who underwent DIEP flap breast reconstruction performed by the senior author (M.S.-C). Data were collected on patient demographics and surgical outcomes...
November 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27771262/outcome-after-urgent-microvascular-revision-of-free-diep-siea-and-sgap-flaps-for-autologous-breast-reconstruction
#11
A Vanschoonbeek, G Fabre, L Nanhekhan, M Vandevoort
INTRODUCTION: Microvascular complications after free flap breast reconstruction are devastating, and revision of a compromised breast reconstruction is very challenging. The aim of this study was to review the different characteristics of urgent microvascular revision in DIEP, SIEA and SGAP flaps and to evaluate the final outcome after revision. MATERIALS AND METHODS: A retrospective chart review was performed for all patients who underwent an autologous breast reconstruction with a DIEP, SIEA or SGAP flap at the University Hospitals of Leuven between August 1997 and December 2013...
September 28, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27763439/inequalities-in-tooth-decay-in-australian-children-by-neighbourhood-characteristics-and-indigenous-status
#12
Ratilal Lalloo, Lisa M Jamieson, Diep Ha, Liana Luzzi
OBJECTIVE: Tooth decay is related to poverty, measured at individual and neighbourhood levels. It is however uncertain if living in an advantaged neighbourhood reduces tooth decay similarly in Australian Indigenous and non-Indigenous children. METHODS: This study describes tooth decay by neighbourhood characteristics and Indigenous status, and examines inequalities by Indigenous status. RESULTS: In deciduous dentition the percentage of children with tooth decay and untreated decay decreased on average 26% and 20% respectively in the non-Indigenous sample from poor to affluent neighbourhoods...
2016: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/27763435/changes-in-area-level-socioeconomic-status-and-oral-health-of-indigenous-australian-children
#13
Diep H Ha, Loc G Do, Liana Luzzi, Gloria C Mejia, Lisa Jamieson
OBJECTIVE: Dental diseases have shown to be influenced by area-level socioeconomic status. This study aims to assess the effects of change in area-level SES on the oral health of Australian Indigenous children. METHODS: Data were collected from a national surveillance survey for children's dental health at two points of time (2000-2002/2007-2010). The study examines caries experienced by area-level SES and whether changes in area-level SES (stable-high, upwardly-mobile, downwardly-mobile and stable low) affects caries experience...
2016: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/27724934/effect-of-herd-size-on-subclinical-infection-of-swine-in-vietnam-with-influenza-a-viruses
#14
Nobuhiro Takemae, Yugo Shobugawa, Phuong Thanh Nguyen, Tung Nguyen, Tien Ngoc Nguyen, Thanh Long To, Phuong Duy Thai, Tho Dang Nguyen, Duy Thanh Nguyen, Dung Kim Nguyen, Hoa Thi Do, Thi Quynh Anh Le, Phan Truong Hua, Hung Van Vo, Diep Thi Nguyen, Dang Hoang Nguyen, Yuko Uchida, Reiko Saito, Takehiko Saito
BACKGROUND: Influenza A viruses of swine (IAV-S) cause acute and subclinical respiratory disease. To increase our understanding of the etiology of the subclinical form and thus help prevent the persistence of IAV-S in pig populations, we conducted active virologic surveillance in Vietnam, the second-largest pig-producing country in Asia, from February 2010 to December 2013. RESULTS: From a total of 7034 nasal swabs collected from clinically healthy pigs at 250 farms and 10 slaughterhouses, we isolated 172 IAV-S from swine at the weaning and early-fattening stages...
October 10, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27713917/complete-diep-flap-survival-following-pedicle-resection-4-years-after-its-transfer-clinical-evidence-of-autonomization
#15
Benedetto Longo, Rosaria Laporta, Michail Sorotos, Matteo Atzeni, Fabio Santanelli di Pompeo
We report a case of complete DIEP flap survival, following venous congestion due to the excision of a local recurrence with main pedicle, 4 years after its transfer for breast reconstruction.
2016: Case Reports in Plastic Surgery & Hand Surgery
https://www.readbyqxmd.com/read/27695121/the-potential-of-class-ii-bacteriocins-to-modify-gut-microbiota-to-improve-host-health
#16
Özgün C O Umu, Christine Bäuerl, Marije Oostindjer, Phillip B Pope, Pablo E Hernández, Gaspar Pérez-Martínez, Dzung B Diep
Production of bacteriocins is a potential probiotic feature of many lactic acid bacteria (LAB) as it can help prevent the growth of pathogens in gut environments. However, knowledge on bacteriocin producers in situ and their function in the gut of healthy animals is still limited. In this study, we investigated five bacteriocin-producing strains of LAB and their isogenic non-producing mutants for probiotic values. The LAB bacteriocins, sakacin A (SakA), pediocin PA-1 (PedPA-1), enterocins P, Q and L50 (enterocins), plantaricins EF and JK (plantaricins) and garvicin ML (GarML), are all class II bacteriocins, but they differ greatly from each other in terms of inhibition spectrum and physicochemical properties...
2016: PloS One
https://www.readbyqxmd.com/read/27680708/corrigendum-an-essential-receptor-for-adeno-associated-virus-infection
#17
S Pillay, N L Meyer, A S Puschnik, O Davulcu, J Diep, Y Ishikawa, L T Jae, J E Wosen, C M Nagamine, M S Chapman, J E Carette
No abstract text is available yet for this article.
September 28, 2016: Nature
https://www.readbyqxmd.com/read/27664157/frequent-use-of-colistin-based-drug-treatment-to-eliminate-extended-spectrum-beta-lactamase-producing-escherichia-coli-in-backyard-chicken-farms-in-thai-binh-province-vietnam
#18
Tatsuya Nakayama, Michio Jinnai, Ryuji Kawahara, Khong Thi Diep, Nguyen Nam Thang, Tran Thi Hoa, Le Kieu Hanh, Pham Ngoc Khai, Yoshinori Sumimura, Yoshimasa Yamamoto
Reports of livestock infections with extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E) are increasing. Based on interviews conducted over a 6-month period, we found that veterinarians in the Vietnamese province of Thai Binh prefer to prescribe colistin-based drugs (CBD) in chicken farms. We aimed to clarify whether CBD use selects for strains of colistin-resistant ESBL-E. With the cooperation of seven local households, we detected ESBL-E in chickens' feces after treating chickens with CBD...
September 23, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27651974/successful-deep-inferior-epigastric-perforator-flap-harvest-despite-preoperative-therapeutic-subcutaneous-heparin-administration-into-the-abdominal-pannus
#19
Joseph W Duncumb, Kana Miyagi, Parto Forouhi, Charles M Malata
Abdominal free flaps for microsurgical breast reconstruction are most commonly harvested based on the deep inferior epigastric vessels that supply skin and fat via perforators through the rectus muscle and sheath. Intact perforator anatomy and connections are vital for subsequent optimal flap perfusion and avoidance of necrosis, be it partial or total. The intraflap vessels are delicate and easily damaged and it is generally advised that patients should avoid heparin injection into the abdominal pannus preoperatively as this may compromise the vascular perforators through direct needle laceration, pressure from bruising, haematoma formation, or perforator thrombosis secondary to external compression...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27647838/esterification-of-24s-ohc-induces-formation-of-atypical-lipid-droplet-like-structures-leading-to-neuronal-cell-death
#20
Wakako Takabe, Yasuomi Urano, Diep-Khanh Ho Vo, Kimiyuki Shibuya, Masaki Tanno, Hiroaki Kitagishi, Toyoshi Fujimoto, Noriko Noguchi
The 24(S)-hydroxycholesterol (24S-OHC), which plays an important role in maintaining brain cholesterol homeostasis, has been shown to possess neurotoxicity. We have previously reported that 24S-OHC esterification by ACAT1 and the resulting lipid droplet (LD) formation are responsible for 24S-OHC-induced cell death. In the present study, we investigate the functional roles of 24S-OHC esters and LD formation in 24S-OHC-induced cell death, and we identify four long-chain unsaturated fatty acids (oleic acid, linoleic acid, arachidonic acid, and DHA) with which 24S-OHC is esterified in human neuroblastoma SH-SY5Y cells treated with 24S-OHC...
November 2016: Journal of Lipid Research
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