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https://www.readbyqxmd.com/read/29334546/impact-of-early-antiretroviral-therapy-eligibility-on-hiv-acquisition-household-level-evidence-from-rural-south-africa
#1
Catherine E Oldenburg, Jacob Bor, Guy Harling, Frank Tanser, Tinofa Mutevedzi, Maryam Shahmanesh, George R Seage, Victor De Gruttola, Matthew J Mimiaga, Kenneth H Mayer, Deenan Pillay, Till Bärnighausen
OBJECTIVES: We investigate the effect of immediate ART eligibility on HIV incidence among HIV-uninfected household members. DESIGN: Regression discontinuity study arising from a population-based cohort. METHODS: Household members of patients seeking care at the Hlabisa HIV Treatment and Care Programme in rural KwaZulu-Natal South Africa between January 2007 and August 2011 with CD4 counts up to 350 cells/μl were eligible for inclusion if they had at least two HIV tests and were HIV-uninfected at the time the index patient linked to care (N = 4,115)...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29333778/-remineralization-effect-of-casein-phosphopeptide-amorphous-calcium-phosphate-for-enamel-demineralization-a-system-review
#2
Wang Xiaotong, Rao Nanquan, Xie Jing, Zhao Yuming, Ge Lihong
OBJECTIVE: This study  aims  to  assess  the  remineralization effect of casein phosphopeptide (CPP)-amorphous calcium phosphate (ACP) on enamel demineralization by  performing  system review of  randomized  controlled  trials (RCT)  involving  the  treatment of enamel demineralization with  CPP-ACP. METHODS: The  study  was  developed  based  on  the 
Cochrane handbook  for  systematic  reviews of  interventions (Version 5...
December 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29333752/workplace-design-for-the-australian-residential-aged-care-workforce
#3
Lucio Naccarella, Clare Newton, Alan Pert, Kurt Seemann, Ruth Williams, Kate Sellick, Briony Dow
OBJECTIVES: This research explored residential aged care (RAC) workplace design features that influence how RAC staff feel valued, productive, safe, like they belong and connected. A secondary aim was to validate emerging themes about RAC design features with stakeholders. METHODS: A multistage qualitative study was conducted in one RAC facility with 100 residents in outer metropolitan Melbourne: (i) photo-elicitation - photographs were used to prompt discussions with RAC staff; (ii) individual interviews with RAC directors; and (iii) validity testing with the advisory committee occurred...
January 14, 2018: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/29333062/helicobacter-pylori-infection-and-esophageal-adenocarcinoma-a-review-and-a-personal-view
#4
REVIEW
Stergios A Polyzos, Christos Zeglinas, Fotini Artemaki, Michael Doulberis, Evangelos Kazakos, Panagiotis Katsinelos, Jannis Kountouras
Esophageal adenocarcinoma (EAC) is etiologically associated with gastroesophageal reflux disease (GERD). There is evidence to support the sequence GERD, Barrett's esophagus (BE), dysplasia, and finally EAC, with Helicobacter pylori (H. pylori) being implicated in each step to EAC. On the other side of this relation stands the hypothesis of the protective role of H. pylori against EAC. Based on this controversy, our aim was to review the literature, specifically original clinical studies and meta-analyses linking H...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29332525/bar-training-for-active-bystanders-evaluation-of-a-community-based-bystander-intervention-program
#5
Ráchael A Powers, Jennifer Leili
Bystander intervention programs are proliferating on college campuses and are slowly gaining momentum as sexual violence prevention programs suitable for the larger community. In particular, bystander intervention programs aimed at bar staff have been developed in a number of locations. This study entails the exploratory evaluation of a community-based bystander program for bar staff. Using a pre-posttest design, this study suggests that evidence surrounding the effectiveness of this program is promising as it decreases rape myths, decreases barriers to intervention, and increases bartenders willingness to intervene...
December 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29331223/structure-based-design-and-application-of-a-nucleotide-coenzyme-mimetic-ligand-application-to-the-affinity-purification-of-nucleotide-dependent-enzymes
#6
Marigianna Marinou, Dimitrios Platis, Farid S Ataya, Evangelia Chronopoulou, Dimitrios Vlachakis, Nikolaos E Labrou
In the present study, a structure-based approach was exploited for the in silico design of a nucleotide coenzyme mimetic ligand. The enzyme formate dehydrogenase (FDH) was employed as a model in our study. The biomimetic ligand was designed and synthesized based on a tryptamine/3-aminopropylphosphonic acid bi-substituted 1,3,5-triazine (Trz) scaffold (Tra-Trz-3APP), which potentially mimics the interactions of NAD+-FDH complex. Molecular docking studies of the biomimetic ligand predicted that it can occupy the same binding site as the natural coenzyme...
January 3, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29331213/-methodology-for-the-development-of-policy-brief-in-public-health
#7
Emily Felt, José Miguel Carrasco, Carmen Vives-Cases
A policy brief is a document that summarizes research to inform policy. In a brief and succinct way, it defines a policy problem, presents a synthesis of relevant evidence, identifies possible courses of action and makes recommendations or key points. The objective of this note is to describe the methodology used to produce a policy brief for communicating public health research. This note is based on the model presented by Eugene Bardach in addition to the authors' own experiences. We describe six steps: 1) identifying the audience; 2) defining the problem; 3) gathering information and evidence; 4) consideration of policy alternatives; 5) projecting results and designing recommendations; and 6) telling the story...
January 10, 2018: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#8
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29330082/clinical-trials-recruitment-planning-a-proposed-framework-from-the-clinical-trials-transformation-initiative
#9
Grant D Huang, Jonca Bull, Beth Harper, Elizabeth Mahon, Kelly McKee, Jamie N Roberts
Patient recruitment is widely recognized as a key determinant of success for clinical trials. Yet a substantial number of trials fail to reach recruitment goals-a situation that has important scientific, financial, ethical, and policy implications. Further, there are important effects on stakeholders who directly contribute to the trial including investigators, sponsors, and study participants. Despite efforts over multiple decades to identify and address barriers, recruitment challenges persist. To advance a more comprehensive approach to trial recruitment, the Clinical Trials Transformation Initiative (CTTI) convened a project team to examine the challenges and to issue actionable, evidence-based recommendations for improving recruitment planning that extend beyond common study-specific strategies...
January 9, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29329680/correlation-of-severity-of-chronic-obstructive-pulmonary-disease-with-potential-biomarkers
#10
Seema Singh, S K Verma, Santosh Kumar, M K Ahmad, Anuradha Nischal, S K Singh, R K Dixit
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a non-specific inflammation, which involves the airways, lung parenchyma and pulmonary vessels. The inflammation causes the activation of inflammatory cells and the release of various inflammatory mediators such as interleukin-1 beta, interleukin-6 and tumor necrosis factor alpha (TNF-a). The present study was designed to assess the serum cytokines [Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α)] levels in chronic obstructive pulmonary disease (COPD) patients and they were correlated with severity of disease by spirometric measurements...
January 9, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29329457/a-novel-application-of-rnase-h2-dependent-quantitative-pcr-for-detection-and-quantification-of-grosmannia-clavigera-a-mountain-pine-beetle-fungal-symbiont-in-environmental-samples
#11
Chandra H McAllister, Colleen E Fortier, Kate R St Onge, Bianca M Sacchi, Meaghan J Nawrot, Troy Locke, Janice E K Cooke
Mountain pine beetle (Dendroctonus ponderosae Hopkins; MPB) is an economically and ecologically important pest of pine species in western North America. Mountain pine beetles form complex multipartite relationships with microbial partners, including the ophiostomoid fungi Grosmannia clavigera (Robinson-Jeffrey and Davidson) Zipfel, de Beer and Wingfield, Ophiostoma montium (Rumbold) von Arx, Grosmannia aurea (Robinson-Jeffrey and Davidson) Zipfel, de Beer and Wingfield, Leptographium longiclavatum (Lee, Kim, and Breuil) and Leptographium terebrantis (Barras and Perry)...
January 10, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29329455/serologic-evidence-of-ebolavirus-infection-in-a-population-with-no-history-of-outbreaks-in-the-democratic-republic-of-the-congo
#12
Sabue Mulangu, Vivian H Alfonso, Nicole A Hoff, Reena H Doshi, Prime Mulembakani, Neville K Kisalu, Emile Okitolonda-Wemakoy, Benoit Ilunga Kebela, Hadar Marcus, Joseph Shiloach, Je Nie Phue, Linda L Wright, Jean-Jacques Muyembe-Tamfum, Nancy J Sullivan, Anne W Rimoin
Background: Previous studies suggest that cases of Ebola virus disease (EVD) may go unreported because they are asymptomatic or unrecognized, but evidence is limited by study designs and sample size. Methods: A large population-based survey was conducted (n = 3415) to assess animal exposures and behaviors associated with Ebolavirus antibody prevalence in rural Kasai Oriental province of the Democratic Republic of Congo (DRC). Fourteen villages were randomly selected and all healthy individuals ≥1 year of age were eligible...
January 10, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29329438/patient-perspectives-on-how-physicians-communicate-diagnostic-uncertainty-an-experimental-vignette-study
#13
Viraj Bhise, Ashley N D Meyer, Shailaja Menon, Geeta Singhal, Richard L Street, Traber D Giardina, Hardeep Singh
Objective: We evaluated the effects of three different strategies for communicating diagnostic uncertainty on patient perceptions of physician competence and visit satisfaction. Design/Setting: Experimental vignette-based study design involving pediatric cases presented to a convenience sample of parents living in a large US city. Participants/Intervention(s): Three vignettes were developed, each describing one of three different ways physicians communicated diagnostic uncertainty to parents-(i) explicit expression of uncertainty ('not sure' about diagnosis), (ii) implicit expression of uncertainty using broad differential diagnoses and (iii) implicit expression of uncertainty using 'most likely' diagnoses...
January 10, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29329359/effectiveness-of-mass-media-campaigns-to-reduce-alcohol-consumption-and-harm-a-systematic-review
#14
Ben Young, Sarah Lewis, Srinivasa Vittal Katikireddi, Linda Bauld, Martine Stead, Kathryn Angus, Mhairi Campbell, Shona Hilton, James Thomas, Kate Hinds, Adela Ashie, Tessa Langley
Aims: To assess the effectiveness of mass media messages to reduce alcohol consumption and related harms using a systematic literature review. Methods: Eight databases were searched along with reference lists of eligible studies. Studies of any design in any country were included, provided that they evaluated a mass media intervention targeting alcohol consumption or related behavioural, social cognitive or clinical outcomes. Drink driving interventions and college campus campaigns were ineligible...
January 10, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29327367/the-free-healthcare-initiative-in-sierra-leone-evaluating-a-health-system-reform-2010-2015
#15
Sophie Witter, Nouria Brikci, Tim Harris, Richard Williams, Sarah Keen, Ana Mujica, Alex Jones, Alex Murray-Zmijewski, Barbara Bale, Bailah Leigh, Ade Renner
This article presents the findings of a theory-based evaluation of the Sierra Leone Free Health Care Initiative (FHCI), using mixed methods. Analytical approaches included time-series analysis of national survey data to examine mortality and morbidity trends, as well as modelling of impact using the Lives Saved Tool and expenditure trend analysis. We find that the FHCI responded to a clear need in Sierra Leone, was well designed to bring about needed changes in the health system to deliver services to the target beneficiaries, and did indeed bring funds and momentum to produce important systemic reforms...
January 12, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29326817/seating-in-aged-care-physical-fit-independence-and-comfort
#16
Alethea Blackler, Claire Brophy, Maria O'Reilly, Marianella Chamorro-Koc
Objectives: This research was intended to provide a greater understanding of the context and needs of aged care seating, specifically:To conduct an audit of typical chairs used in aged care facilities;To collect data about resident and staff experiences and behaviour around chairs in order to gain a deeper understanding of the exact issues that residents and staff have with the chairs they use at aged care facilities;To identify positive and negative issues influencing use of chairs in aged care facilities;To deliver evidence-based recommendations for the design of chairs for aged care facilities...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29326101/pathways-over-time-functional-genomics-research-in-an-introductory-laboratory-course
#17
Todd D Reeves, Douglas M Warner, Larry H Ludlow, Clare M O'Connor
National reports have called for the introduction of research experiences throughout the undergraduate curriculum, but practical implementation at many institutions faces challenges associated with sustainability, cost, and large student populations. We describe a novel course-based undergraduate research experience (CURE) that introduces introductory-level students to research in functional genomics in a 3-credit, multisection laboratory class. In the Pathways over Time class project, students study the functional conservation of the methionine biosynthetic pathway between divergent yeast species...
2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29325871/use-of-uv-fluorescence-based-simulation-in-evaluation-of-personal-protective-equipment-worn-for-first-assessment-and-care-of-a-patient-with-suspected-high-consequence-infectious-disease
#18
Samantha Hall, Bozena Poller, Claire Bailey, Samantha Gregory, Richard Clark, Paul Roberts, Anne Tunbridge, Vin Poran, Cariad Evans, Brian Crook
BACKGROUND: Variations currently exist across the UK in the choice of personal protective equipment (PPE) used by healthcare workers when caring for patients with suspected high consequence infectious diseases (HCIDs). AIM: To test the protection afforded to healthcare workers by current PPE ensembles during assessment of a suspected HCID case and to provide an evidence base to justify proposal of a unified PPE ensemble for healthcare workers across the UK. METHODS: One 'basic level' (enhanced precautions) PPE ensemble and five 'suspected case' PPE ensembles were evaluated in volunteer trials using 'Violet'; a UV-fluorescence-based simulation exercise to visualise exposure/contamination events...
January 8, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29325808/dutch-breast-reconstruction-guideline
#19
REVIEW
Marc A M Mureau
Treatment of breast cancer is complex and multidisciplinary by nature, with protocols that are updated continuously. During preoperative multidisciplinary team meetings, regularly there is discussion between team members regarding optimal timing and type of breast reconstruction, due to conflicting interests of oncological and reconstructive treatments. Therefore, a multidisciplinary, evidence-based guideline for breast reconstruction in women undergoing breast conserving therapy or mastectomy for breast cancer, or following prophylactic mastectomy was developed by a multidisciplinary working group...
December 27, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29325533/a-systematic-review-of-comparisons-between-protocols-or-registrations-and-full-reports-in-primary-biomedical-research
#20
Guowei Li, Luciana P F Abbade, Ikunna Nwosu, Yanling Jin, Alvin Leenus, Muhammad Maaz, Mei Wang, Meha Bhatt, Laura Zielinski, Nitika Sanger, Bianca Bantoto, Candice Luo, Ieta Shams, Hamnah Shahid, Yaping Chang, Guangwen Sun, Lawrence Mbuagbaw, Zainab Samaan, Mitchell A H Levine, Jonathan D Adachi, Lehana Thabane
BACKGROUND: Prospective study protocols and registrations can play a significant role in reducing incomplete or selective reporting of primary biomedical research, because they are pre-specified blueprints which are available for the evaluation of, and comparison with, full reports. However, inconsistencies between protocols or registrations and full reports have been frequently documented. In this systematic review, which forms part of our series on the state of reporting of primary biomedical, we aimed to survey the existing evidence of inconsistencies between protocols or registrations (i...
January 11, 2018: BMC Medical Research Methodology
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