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https://www.readbyqxmd.com/read/29793112/3d-printed-membrane-as-an-alternative-to-amniotic-membrane-for-ocular-surface-conjunctival-defect-reconstruction-an-in-vitro-in-vivo-study
#1
Shima Dehghani, Morteza Rasoulianboroujeni, Hamed Ghasemi, Saeed Heidari Keshel, Zohreh Nozarian, Mohammad Naser Hashemian, Mehran Zarei-Ghanavati, Golshan Latifi, Reza Ghaffari, Zhanfeng Cui, Hua Ye, Lobat Tayebi
BACKGROUND: The aim of this study was to evaluate the surgical handling and clinical applicability of a specific 3D-printed membrane design fabricated using a gelatin, elastin and sodium hyaluronate blend for conjunctival reconstruction and compare it with amniotic membrane (AM), which is normally used in such surgeries. METHODS: 3D printing technique was employed to fabricate the membrane based on gradient design. Prior to printing, rheometry was employed to optimize the ink composition...
May 11, 2018: Biomaterials
https://www.readbyqxmd.com/read/29792807/micelles-protect-intact-metallo-supramolecular-block-copolymer-complexes-from-solution-to-gas-phase-during-electrospray-ionization
#2
Kai Hung Huang, Tsung-Han Tu, Shi-Cheng Wang, Yi-Tsu Chan, Cheng-Chih Hsu
Supramolecular diblock copolymers using metal-ligand coordination can be synthesized under ambient conditions by delicate design of the end groups of the homopolymer chains. However, mass spectrometric analysis of such metallo-supramolecular copolymers is challenging. One of the reasons is the nonpolarity of the polymer chains, making it hard to disperse the complexes in electrospray ionization (ESI)-friendly environments. The other difficulty is the noncovalent nature of such copolymers, which is easily disrupted during the ionization...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792776/prevalence-of-inadequate-immunity-to-measles-mumps-rubella-and-varicella-in-mlb-and-nba-athletes
#3
Justin J Conway, Brett G Toresdahl, Daphne I Ling, Nicole T Boniquit, Lisa R Callahan, James J Kinderknecht
BACKGROUND: Multiple outbreaks of vaccine-preventable viral diseases have occurred in professional sports in recent years. Currently, there is no established protocol for vaccination or immunity screening for professional athletes. HYPOTHESIS: There are significant differences in the prevalence of inadequate immunity dependent on age, sport, country of birth, and participation in collegiate sports. STUDY DESIGN: Cross-sectional cohort study...
May 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29792703/structure-based-design-of-inhibitors-with-improved-selectivity-for-steroidogenic-cytochrome-p450-17a1-over-cytochrome-p450-21a2
#4
Charlie Fehl, Caleb D Vogt, Rahul Yadav, Kelin Li, Emily E Scott, Jeffrey Aubé
Inhibition of androgen biosynthesis is clinically effective for treating androgen-responsive prostate cancer. Abiraterone is a clinical first-in-class inhibitor of cytochrome P450 17A1 (CYP17A1) required for androgen biosynthesis. However, abiraterone also causes hypertension, hypokalemia, and edema, likely due in part to off-target inhibition of another steroidogenic cytochrome P450, CYP21A2. Abiraterone analogs were designed based on structural evidence that B-ring substituents may favorably interact with polar residues in binding CYP17A1 and sterically clash with residues in the CYP21A2 active site...
May 24, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29792465/team-development-interventions-evidence-based-approaches-for-improving-teamwork
#5
Christina N Lacerenza, Shannon L Marlow, Scott I Tannenbaum, Eduardo Salas
The rate of teamwork and collaboration within the workforce has burgeoned over the years, and the use of teams is projected to continue increasing. With the rise of teamwork comes the need for interventions designed to enhance teamwork effectiveness. Successful teams produce desired outcomes; however, it is critical that team members demonstrate effective processes to achieve these outcomes. Team development interventions (TDIs) increase effective team competencies and processes, thereby leading to improvements in proximal and distal outcomes...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29792441/human-memory-reconsolidation-a-guiding-framework-and-critical-review-of-the-evidence
#6
James W B Elsey, Vanessa A Van Ast, Merel Kindt
Research in nonhuman animals suggests that reactivation can induce a transient, unstable state in a previously consolidated memory, during which the memory can be disrupted or modified, necessitating a process of restabilization in order to persist. Such findings have sparked a wave of interest into whether this phenomenon, known as reconsolidation, occurs in humans. Translating research from animal models to human experiments and even to clinical interventions is an exciting prospect, but amid this excitement, relatively little work has critically evaluated and synthesized existing research regarding human memory reconsolidation...
May 24, 2018: Psychological Bulletin
https://www.readbyqxmd.com/read/29791867/longitudinal-assessment-of-chemotherapy-induced-changes-in-brain-and-cognitive-functioning-a-systematic-review
#7
REVIEW
Mingmei Li, Karen Caeyenberghs
In addition to the burden of a life-threatening diagnosis, cancer patients are struggling with adverse side-effects from cancer treatment. Chemotherapy has been linked to an array of cognitive impairments and alterations in brain structure and function ("chemobrain"). In this review, we summarized the existing evidence that evaluate the changes in cognitive functioning and brain with chemotherapy, as assessed using structural and functional MRI-based techniques in a longitudinal design. This review followed the latest PRISMA guidelines using Embase, Medline, PsychINFO, Scopus, and Web of Science databases with date restrictions from 2012-2017...
May 20, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29791738/designing-testing-and-implementing-a-sustainable-nurse-home-visiting-program-right-home
#8
Sharon Goldfeld, Anna Price, Lynn Kemp
Nurse home visiting (NHV) offers a potential platform to both address the factors that limit access to services for families experiencing adversity and provide effective interventions. Currently, the ability to examine program implementation is hampered by a lack of detailed description of actual, rather than expected, program development and delivery in published studies. Home visiting implementation remains a black box in relation to quality and sustainability. However, previous literature would suggest that efforts to both report and improve program implementation are vital for NHV to have population impact and policy sustainability...
May 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29790842/reviewing-the-who-guidelines-for-antibiotic-use-for-sepsis-in-neonates-and-children
#9
Aline Fuchs, Julia Bielicki, Shrey Mathur, Mike Sharland, Johannes N Van Den Anker
Background Guidelines from 2005 for treating suspected sepsis in low- and middle-income countries (LMIC) recommended hospitalisation and prophylactic intramuscular (IM) or intravenous (IV) ampicillin and gentamicin. In 2015, recommendations when referral to hospital is not possible suggest the administration of IM gentamicin and oral amoxicillin. In an era of increasing antimicrobial resistance, an updated review of the appropriate empirical therapy for treating sepsis (taking into account susceptibility patterns, cost and risk of adverse events) in neonates and children is necessary...
November 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29789518/olive-oil-and-soybean-oil-based-intravenous-lipid-emulsions-liver-biochemistry-and-clinical-outcomes
#10
Fabio Araujo, Tanis R Fenton, Sara Lukmanji, Maitreyi Raman
Intravenous lipid emulsions are an essential component of parenteral nutrition (PN). Omega-6 reducing strategies may improve outcomes, including reduced PN associated liver disease, however evidence to support this recommendation is insufficient. The primary objective was to compare serum alkaline phosphatase (ALP), among patients provided with either soybean oil (Intralipid) or predominantly olive oil (Clinoleic) lipid emulsions. In this quasi-experimental study, we reviewed the medical records of surgical and medical adult patients who received lipid emulsions for at least seven consecutive days...
May 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29789099/building-capacity-for-change-evaluation-of-an-organisation-wide-leadership-development-program
#11
Tim Schultz, Jodie Shoobridge, Gill Harvey, Libby Carter, Alison Kitson
Objective. This study evaluated Leading 4 Change, a change leadership development program designed to support healthcare middle managers through a period of significant organisational change and enhance workplace resilience. Methods. A mixed methods evaluation was conducted within the program's framework of a quality improvement activity. Quantitative measures were participant responses (n=160) to online questionnaires, which were compared before and after the program, using an uncontrolled pre-post study design...
May 23, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29788807/evidence-for-telehealth-group-based-treatment-a-systematic-review
#12
Melanie T Gentry, Maria I Lapid, Matthew M Clark, Teresa A Rummans
Background Interest in the use of telehealth interventions to increase access to healthcare services is growing. Group-based interventions have the potential to increase patient access to highly needed services. The aim of this study was to systematically review the available literature on group-based video teleconference services. Methods The English-language literature was searched using Ovid MEDLINE, PubMed, PsycINFO and CINAHL for terms related to telehealth, group therapy and support groups. Abstracts were reviewed for relevance based on inclusion criteria...
January 1, 2018: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29788034/sleep-disorders-including-sleep-apnea-and-hypertension
#13
E M Van Ryswyk, S Mukherjee, C L Chai-Coetzer, A Vakulin, R D McEvoy
There is mounting evidence for an association between sleep disorders and hypertension. In obstructive sleep apnea (OSA) there are plausible biological reasons for the development of hypertension, and treatment of OSA results in modest (2-3 mmHg), adherence-dependent decreases in blood pressure (BP), with larger effects evident in those with resistant hypertension. However, prospective, population-based cohort studies have not yet convincingly demonstrated a link between OSA and incident hypertension, and adequately powered controlled trials of CPAP for the prevention or treatment or hypertension are lacking...
May 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29787858/a-randomized-clinical-trial-of-counseling-and-nicotine-replacement-therapy-for-treatment-of-african-american-non-daily-smokers-design-accrual-and-baseline-characteristics
#14
Nicole L Nollen, Lisa Sanderson Cox, Matthew S Mayo, Edward F Ellerbeck, Sheshadri Madhusudhana, Jasjit S Ahluwalia
BACKGROUND: Non-daily smokers (NDS) who smoke on some but not all days are a growing subset of United States (US) tobacco users. Racial/ethnic minorities are more likely to be NDS. African American NDS have strikingly high levels of nicotine and carcinogen exposure, making treatment of this high risk group a priority. METHODS: The current study is one of three ongoing federally-funded clinical trials of NDS and, to our knowledge the only RCT focused on racial/ethnic minority NDS...
May 19, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29787697/rehabilitation-practice-patterns-following-anterior-cruciate-ligament-reconstruction-a-survey-of-physical-therapists
#15
Elliot M Greenberg, Eric T Greenberg, Jeffrey Albaugh, Eileen Storey, Theodore J Ganley
Study Design Cross-sectional survey. Background Recovery from anterior cruciate ligament reconstruction (ACLR) requires an intensive course of post-operative rehabilitation. Although guidelines outlining evidence-based rehabilitation recommendations have been published, the actual practice patterns of physical therapists are unknown. Objectives To analyze the current landscape of clinical practice as it pertains to rehabilitation progression and the use of time and objective criteria following ACLR. Methods An online survey was distributed to members of the orthopaedics, sports and private practice sections of the American Physical Therapy Association (APTA) between January and March 2017...
May 22, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29787696/impact-of-risk-adjustment-on-provider-ranking-for-patients-with-low-back-pain-receiving-physical-therapy
#16
Daniel Deutscher, Mark W Werneke, Deanna Hayes, Jerome E Mioduski, Karon F Cook, Julie Fritz, Linda J Woodhouse, Paul W Stratford
Study Design Retrospective cohort. Background Impact of risk-adjustment on clinic quality ranking for patients treated in physical therapy outpatient clinics is unknown. Objectives To compare clinic ranking, based on unadjusted vs. risk-adjusted outcomes, for patients with low back pain (LBP) treated in physical therapy. Methods Secondary analysis of data from adult patients with LBP treated in outpatient physical therapy clinics during 2014-2016. Patients with complete outcomes data at admission and discharge were included to develop the risk-adjustment model...
May 22, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29787385/a-systematic-review-and-narrative-synthesis-to-explore-the-effectiveness-of-exercise-based-interventions-in-improving-fatigue-dyspnea-and-depression-in-lung-cancer-survivors
#17
Catherine L Henshall, Lizzie Allin, Helen Aveyard
BACKGROUND: Lung cancer survival rates are increasing; however, lung cancer survivors' mental and physical well-being can suffer from experiencing symptoms of fatigue, dyspnea, and depression. Exercise can improve these symptoms. However, no studies have examined the effects of different exercise interventions on these symptoms. OBJECTIVE: This review aims to examine the evidence on the effects of exercise interventions on fatigue, dyspnea, and depression in lung cancer survivors...
May 21, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29786676/-the-modern-approaches-to-the-restoration-of-postural-balance-in-the-patients-suffering-from-the-consequences-of-an-acute-cerebrovascular-accident-cva
#18
S A Volovets, E Y Sergeenko, L Y Darinskaya, B A Polyaev, Y A Yashinina, M A Isaeva, I V Zhitareva, A N Lobov, T I Panova
BACKGROUND: the most frequent and severe consequences of an acute cerebrovascular accident (CVA) are locomotor and coordination disorders which significantly increase the risk of falling in a static position and when walking. The methods used for the rehabilitation of the affected patients are designed in the first place to enable the patients to acquire the skills necessary for maintaining the static balance. The modern equipment allows to carry out coordination training in the static position and also during walking...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29786535/evaluating-the-importance-of-sham-controlled-trials-in-the-investigation-of-medical-devices-in-interventional-cardiology
#19
Robert A Byrne, Davide Capodanno, Felix Mahfoud, Jean Fajadet, Stephan Windecker, Peter Jüni, Andreas Baumbach, William Wijns, Michael Haude
Cardiovascular medicine is one of the specialties that has relied most heavily on evidence from randomized clinical trials in determining best practice for the management of common disease conditions. When comparing treatment approaches, trials incorporating random allocation are the most appropriate method for protecting against treatment allocation bias. In order to protect against performance and ascertainment bias, trial designs including placebo control are preferable where feasible. In contrast to testing of medicines, treatments based on procedures or use of medical devices are more challenging to assess, as sham procedures are necessary to facilitate blinding of participants...
May 22, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29786503/relationships-between-theoretically-derived-short-term-outcomes-and-support-for-policy-among-the-public-and-decision-makers
#20
Carol L Schmitt, Laurel Curry, Vanessa Boudewyns, Pamela A Williams, LaShawn Glasgow, Deanna Van Hersh, Jeffrey Willett, Todd Rogers
PURPOSE AND OBJECTIVES: Policy change is a lengthy and complex process. Thus, it is important to articulate hypothesized causal pathways between advocacy activities and policy change outcomes and to identify and monitor early indicators of progress toward policy change. INTERVENTION APPROACH: The Kansas Health Foundation supports grantee efforts to address the public health effects of obesity through evidence-based policy, systems, and environmental change interventions...
May 17, 2018: Preventing Chronic Disease
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