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Kidney stone analysis

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https://www.readbyqxmd.com/read/28900379/postmenopausal-hormone-and-the-risk-of-nephrolithiasis-a-meta-analysis
#1
Juan Yu, Binyan Yin
Menopause is reported to be associated with increased urinary calcium excretion, which may enhance the risk for the development of calcium kidney stones. However, it remains controversial about whether high level of postmenopausal hormone (PMH) is a risk factor for formation of nephrolithiasis. Several observational studies have shown that PMH is protective based on 24-hour urinary parameters. Recent clinical trials provided evidence to conclude that estrogen therapy increases the risk of nephrolithiasis in healthy postmenopausal women...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28890392/natural-history-and-predictors-of-parastomal-hernia-after-robot-assisted-radical-cystectomy-and-ileal-conduit-urinary-diversion
#2
Ahmed A Hussein, Youssef E Ahmed, Paul May, Taimoor Ali, Basim Ahmad, Sana Raheem, Kevin Stone, Adam Hasasnah, Omer Rana, Adam Cole, Derek Wang, Peter Loud, Khurshid A Guru
INTRODUCTION: We investigated the prevalence, variables associated with parastomal hernia (PSH), and its outcomes of after robot-assisted radical cystectomy (RARC) and ileal conduit (IC) for bladder cancer. METHODS: Retrospective review of RARC at our institution was conducted. PSH was defined as protrusion of abdominal contents through the stoma defect in the abdominal wall on cross sectional imaging. PSH was further described in terms of patient and hernia characteristics, symptoms, management and outcomes...
September 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28887264/toe-pressures-are-superior-to-duplex-parameters-in-predicting-wound-healing-following-toe-and-foot-amputations
#3
Patrick A Stone, Alexis Glomski, Stephanie N Thompson, Elliott Adams
BACKGROUND: No criteria, including pre-amputation vascular diagnostic thresholds, have been established to reliably predict healing versus non-healing following minor lower extremity amputations. Thus, the goal of our study was to identify clinical factors, including non-invasive vascular laboratory measures, associated with wound healing following toe, forefoot, and midfoot amputations. METHODS: We retrospectively examined records of patients receiving elective toe, forefoot, or midfoot amputation at our institution over a 5-year span (2010-2015)...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28882781/ureteroscopic-urinary-stone-treatment-among-patients-with-renal-anomalies-patient-characteristics-and-treatment-outcomes
#4
Jaap D Legemate, Barbaros Baseskioglu, Jakub Dobruch, Jorge Gutierrez-Aceves, Oscar Negrete, Carlos Rioja Sanz, Muharrem Murat Yildiz, Jean Jmch de la Rosette
OBJECTIVES: To evaluate patients' characteristics, surgical procedure data, and outcomes of URS stone treatment in patients with a horseshoe kidney (HSK), ectopic kidney (EK), and malrotated kidney (MK). METHODS: This study is a sub-analysis of the CROES URS Global Study, which was a prospective multicenter observational study, collecting data on URS stone treatment from consecutive patients over a 1-year period. 114 Centers participated in 32 countries. This analysis acuminated on URS stone treatment in the specified renal anomalies: HSK, EK and MK...
September 4, 2017: Urology
https://www.readbyqxmd.com/read/28882031/a-multiregional-italian-cohort-of-24-hour-urine-metabolic-evaluation-in-renal-stone-formers
#5
Francesco Esperto, Martino Marangella, Alberto Trinchieri, Michele Petrarulo, Roberto Miano
BACKGROUND: Nephrolithiasis is a common condition with several studies documenting an increased prevalence over the past four decades. EAU and AUA guidelines recommend 24-hour urine metabolic evaluation in high-risk stone formers. Aim of this study is to retrospectively evaluate the first three years of experience with Lithotest® (Biohealth Italia Srl, Turin, Italy) through the analysis of demographic, clinical and biochemical data collected from a large cohort of patients with kidney stones...
September 7, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28875258/molecular-analysis-of-oxalate-induced-endoplasmic-reticulum-stress-mediated-apoptosis-in-the-pathogenesis-of-kidney-stone-disease
#6
Albert Abhishek, Shaly Benita, Monika Kumari, Divya Ganesan, Eldho Paul, Ponnusamy Sasikumar, Ayyavu Mahesh, Subramani Yuvaraj, Tharmarajan Ramprasath, Govindan Sadasivam Selvam
Oxalate, a non-essential end product of metabolism, causes hyperoxaluria and eventually calcium oxalate (CaOx) stone disease. Kidney cells exposed to oxalate stress results in generation of reactive oxygen species (ROS) and progression of stone formation. Perturbations in endoplasmic reticulum (ER) result in accumulation of misfolded proteins and Ca(2+) ions homeostasis imbalance and serve as a common pathway for various diseases, including kidney disorders. ER stress induces up-regulation of pro-survival protein glucose-regulated protein 78 (GRP78) and pro-apoptotic signaling protein C/EBP homologous protein (CHOP)...
September 5, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28868511/optimization-of-urinary-dipstick-ph-are-multiple-dipstick-ph-readings-reliably-comparable-to-commercial-24-hour-urinary-ph
#7
Joel E Abbott, Daniel L Miller, William Shi, David Wenzler, Fuad F Elkhoury, Nishant D Patel, Roger L Sur
PURPOSE: Accurate measurement of pH is necessary to guide medical management of nephrolithiasis. Urinary dipsticks offer a convenient method to measure pH, but prior studies have only assessed the accuracy of a single, spot dipstick. Given the known diurnal variation in pH, a single dipstick pH is unlikely to reflect the average daily urinary pH. Our goal was to determine whether multiple dipstick pH readings would be reliably comparable to pH from a 24-hour urine analysis. MATERIALS AND METHODS: Kidney stone patients undergoing a 24-hour urine collection were enrolled and took images of dipsticks from their first 3 voids concurrently with the 24-hour collection...
September 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28861302/factors-associated-with-postoperative-pain-after-retrograde-intrarenal-surgery-for-kidney-stones
#8
Ural Oğuz, Tolga Şahin, Çağrı Şenocak, Ekrem Özyuvalı, Ömer Faruk Bozkurt, Berkan Reşorlu, Ali Ünsal
OBJECTIVE: We aimed to investigate factors related to early postoperative pain after retrograde intrarenal surgery (RIRS). MATERIAL AND METHODS: A prospective data analysis of 250 patients who underwent RIRS due to kidney stones was performed. Postoperative pain was evaluated in all patients by using visual analogue scale (VAS). Patients with severe pain (VAS score ≥7) were separated and included in Group I (n=46). While patients without pain or with insignificant pain were included in Group II (n=204)...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28847730/the-l530r-variation-associated-with-recurrent-kidney-stones-impairs-the-structure-and-function-of-trpv5
#9
Lingyun Wang, Ross P Holmes, Ji-Bin Peng
TRPV5 is a Ca(2+)-selective channel that plays a key role in the reabsorption of Ca(2+) ions in the kidney. Recently, a rare L530R variation (rs757494578) of TRPV5 was found to be associated with recurrent kidney stones in a founder population. However, it was unclear to what extent this variation alters the structure and function of TRPV5. To evaluate the function and expression of the TRPV5 variant, Ca(2+) uptake in Xenopus oocytes and western blot analysis were performed. The L530R variation abolished the Ca(2+) uptake activity of TRPV5 in Xenopus oocytes...
August 25, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28845937/-laparoscopic-pyelolithotomy-for-staghorn-kidney-stones-multi-center-study
#10
A D Kochkin, E A Gallyamov, V L Medvedev, R G Biktimirov, A G Martov, F A Sevryukov, A B Novikov, A E Sanzharov, V P Sergeev
AIM: To analyze the effectiveness and safety of laparoscopic pyelolithotomy (LP) in treating staghorn stones. MATERIALS AND METHODS: A multicentre retrospective analysis of the results of LP performed from January 2004 to December 2016 was conducted. INCLUSION CRITERIA: patients with staghorn calculi K3-K4, who underwent LP as an alternative to percutaneous nephrolithotripsy. The analysis included the incidence and structure of intra- and postoperative complications, the causes of access conversion, operating time, duration of postoperative hospital stay and stone clearance...
July 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28841836/oxalobacter-formigenes-associated-host-features-and-microbial-community-structures-examined-using-the-american-gut-project
#11
Menghan Liu, Hyunwook Koh, Zachary D Kurtz, Thomas Battaglia, Amanda PeBenito, Huilin Li, Lama Nazzal, Martin J Blaser
BACKGROUND: Increasing evidence shows the importance of the commensal microbe Oxalobacter formigenes in regulating host oxalate homeostasis, with effects against calcium oxalate kidney stone formation, and other oxalate-associated pathological conditions. However, limited understanding of O. formigenes in humans poses difficulties for designing targeted experiments to assess its definitive effects and sustainable interventions in clinical settings. We exploited the large-scale dataset from the American Gut Project (AGP) to study O...
August 25, 2017: Microbiome
https://www.readbyqxmd.com/read/28836969/the-application-of-a-novel-integrated-rigid-and-flexible-nephroscope-in-percutaneous-nephrolithotomy-for-renal-staghorn-stones
#12
Huan Yang, Jianxing Li, Gang Long, Shaogang Wang
BACKGROUND: Renal staghorn stones are challenging for urologists to ensure maximum stone clearance and minimal morbidity. Percutaneous nephrolithotomy (PCNL) has become the gold standard treatment for renal staghorn stones. To assess the safety and efficacy of a novel integrated rigid and flexible percutaneous nephroscope(Rigi-flex nephroscope) in PCNL for renal staghorn stones.We present our initial experience with this new technique. METHODS: From March to July 2016, a prospective analysis of 3 patients with staghorn stones treated with Rigi-flex nephroscope in PCNLunder totally ultrasound guidance by paravertebral block (PVB) anesthesia was done...
August 24, 2017: BMC Urology
https://www.readbyqxmd.com/read/28834909/kidney-stones-may-increase-the-risk-of-coronary-heart-disease-and-stroke-a-prisma-compliant-meta-analysis
#13
Jian-Ping Peng, Hang Zheng
BACKGROUND: We aimed to quantitatively assess the potential relationship between kidney stones and coronary heart disease or stroke. METHODS: A meta-analysis was conducted on eligibly studies published before 31 May 2016 in PubMed or Embase. The data were pooled, and the relationship was assessed by the random-effect model with inverse variance-weighted procedure. The results were expressed as relative risk (RR) with 95% confidence intervals (95%CI). RESULTS: Eight studies of 11 cohorts (n = 11) were included in our analysis with 3,658,360 participants and 157,037 cases...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28826249/outcomes-of-ureterorenoscopic-stone-treatment-in-301-patients-with-a-solitary-kidney
#14
Jaap D Legemate, Fernando Marchant Gonzalez, Abderrazak Bouzouita, Shengwen Li, Craig McIlhenny, Nicole L Miller, Alberto Saita, Jean J M C H de la Rosette
OBJECTIVES: To determine the stone-free rates and intra- and postoperative complication rates and grades of ureterorenoscopic stone treatment in patients with a solitary kidney. METHODS: This study is a sub-analysis of the CROES-URS study, which is a prospective international multicenter observational study. Over a one year period consecutive patients treated with ureterorenoscopy for urinary stones were included. Patients entered in this analysis were those with a solitary functioning kidney...
August 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28822796/papillary-ductal-plugging-is-a-mechanism-for-early-stone-retention-in-brushite-stone-disease
#15
James C Williams, Michael S Borofsky, Sharon B Bledsoe, Andrew P Evan, Fredric L Coe, Elaine M Worcester, James E Lingeman
PURPOSE: Mechanisms of early stone retention within the kidney are understudied and poorly understood. To date, attachment via Randall's plaque is the only widely accepted theory in this regard, best described in idiopathic calcium oxalate stone formers. Brushite stone formers are known to have distinct papillary morphology relative to calcium oxalate stone formers. As such, we sought to determine whether stone attachment mechanisms in such patients may be similarly unique. MATERIALS AND METHODS: Patients undergoing percutaneous and or ureteroscopic procedures for stone removal were consented for endoscopic renal papillary examination and individual stone collection...
August 16, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28812535/associating-mutations-causing-cystinuria-with-disease-severity-with-the-aim-of-providing-precision-medicine
#16
Henry J Martell, Kathie A Wong, Juan F Martin, Ziyan Kassam, Kay Thomas, Mark N Wass
BACKGROUND: Cystinuria is an inherited disease that results in the formation of cystine stones in the kidney, which can have serious health complications. Two genes (SLC7A9 and SLC3A1) that form an amino acid transporter are known to be responsible for the disease. Variants that cause the disease disrupt amino acid transport across the cell membrane, leading to the build-up of relatively insoluble cystine, resulting in formation of stones. Assessing the effects of each mutation is critical in order to provide tailored treatment options for patients...
August 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28792520/comparison-of-porous-and-nano-zinc-oxide-for-replacing-high-dose-dietary-regular-zinc-oxide-in-weaning-piglets
#17
Lina Long, Jiashun Chen, Yonggang Zhang, Xiao Liang, Hengjia Ni, Bin Zhang, Yulong Yin
The aim of this study was to compare the effect of dietary supplementation with low dose of porous and nano zinc oxide (ZnO) on weaning piglets, and to evaluate the possibility of using them as an alternative to high dose of regular ZnO. Piglets were randomly allocated into four treatment groups fed with four diets: (1) basal diet (NC), (2) NC+ 3000 mg/kg ZnO (PC), (3) NC + 500 mg/kg porous ZnO (HiZ) and (4) NC + 500 mg/kg nano ZnO (ZNP). The result showed that piglets in HiZ group had less diarrhea than ZNP group (P < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28776078/sarna-mediated-activation-of-trpv5-reduces-renal-calcium-oxalate-deposition-in-rat-via-decreasing-urinary-calcium-excretion
#18
Tao Zeng, Xiaolu Duan, Wei Zhu, Yang Liu, Wenqi Wu, Guohua Zeng
Hypercalciuria is a main risk factor for kidney stone  formation. TRPV5 is the gatekeeper protein for mediating calcium transport and reabsorption in the kidney. In the present study, we tested the effect of TRPV5 activation with small activating RNA (saRNA), which could induce gene expression by targeting the promoter of the gene, on ethylene glycol (EG)-induced calcium oxalate (CaOx) crystals formation in rat kidney. Five pairs of RNA activation sequences targeting the promoter of rat TRPV5 were designed and synthesized...
August 3, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28759644/the-influence-of-serum-uric-acid-on-renal-function-in-patients-with-calcium-or-uric-acid-stone-a-population-based-analysis
#19
Yoshimi Tanaka, Shingo Hatakeyama, Toshikazu Tanaka, Hayato Yamamoto, Takuma Narita, Itsuto Hamano, Teppei Matsumoto, Osamu Soma, Teppei Okamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Ippei Takahashi, Shigeyuki Nakaji, Yuriko Terayama, Tomihisa Funyu, Chikara Ohyama
OBJECTIVES: To determine the influence of serum uric acid (UA) levels on renal impairment in patients with UA stone. MATERIALS AND METHODS: We retrospectively analyzed 463 patients with calcium oxalate and/or calcium phosphate stones (CaOx/CaP), and 139 patients with UA stones. The subjects were divided into the serum UA-high (UA ≥ 7.0 mg/dL) or the UA-low group (UA < 7.0 mg/dL). The control group comprised 3082 community-dwelling individuals that were pair-matched according to age, sex, body mass index, comorbidities, hemoglobin, serum albumin, and serum UA using propensity score matching...
2017: PloS One
https://www.readbyqxmd.com/read/28756355/a-validated-hplc-uv-method-for-the-analysis-of-galloylquinic-acid-derivatives-and-flavonoids-in-copaifera-langsdorffii-leaves
#20
Erick Vicente da Silva Motta, Juliana de Carvalho da Costa, Jairo Kenupp Bastos
Copaifera langsdorffii Desf. (Fabaceae, Caesalpinioideae), popularly known as "copaiba" or "pau d'óleo", is a species of tree that is found throughout Brazil. The leaves of this tree are used in folk medicine to treat kidney stones. Galloylquinic acid derivatives and flavonoids are the main secondary metabolites found in C. langsdorffii leaves and are likely to be responsible for the effectiveness of this treatment. As an attempt to produce a phytotherapic, we have developed a reliable HPLC-UV method for the quality control of C...
July 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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