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Kidney stone analysis

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https://www.readbyqxmd.com/read/27915449/common-variants-in-cldn14-are-associated-with-differential-excretion-of-magnesium-over-calcium-in-urine
#1
REVIEW
Tanguy Corre, Eric Olinger, Sarah E Harris, Michela Traglia, Sheila Ulivi, Stefania Lenarduzzi, Hendrica Belge, Sonia Youhanna, Natsuko Tokonami, Olivier Bonny, Pascal Houillier, Ozren Polasek, Ian J Deary, John M Starr, Daniela Toniolo, Paolo Gasparini, Peter Vollenweider, Caroline Hayward, Murielle Bochud, Olivier Devuyst
The nature and importance of genetic factors regulating the differential handling of Ca(2+) and Mg(2+) by the renal tubule in the general population are poorly defined. We conducted a genome-wide meta-analysis of urinary magnesium-to-calcium ratio to identify associated common genetic variants. We included 9320 adults of European descent from four genetic isolates and three urban cohorts. Urinary magnesium and calcium concentrations were measured centrally in spot urine, and each study conducted linear regression analysis of urinary magnesium-to-calcium ratio on ~2...
December 3, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27915396/accurate-stone-analysis-the-impact-on-disease-diagnosis-and-treatment
#2
REVIEW
Neil S Mandel, Ian C Mandel, Ann M Kolbach-Mandel
This manuscript reviews the requirements for acceptable compositional analysis of kidney stones using various biophysical methods. High-resolution X-ray powder diffraction crystallography and Fourier transform infrared spectroscopy (FTIR) are the only acceptable methods in our labs for kidney stone analysis. The use of well-constructed spectral reference libraries is the basis for accurate and complete stone analysis. The literature included in this manuscript identify errors in most commercial laboratories and in some academic centers...
December 3, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27914711/proteomic-based-research-strategy-identified-laminin-subunit-alpha-2-as-a-potential-urinary-specific-biomarker-for-the-medullary-sponge-kidney-disease
#3
Antonia Fabris, Maurizio Bruschi, Laura Santucci, Giovanni Candiano, Simona Granata, Alessandra Dalla Gassa, Nadia Antonucci, Andrea Petretto, Gian Marco Ghiggeri, Giovanni Gambaro, Antonio Lupo, Gianluigi Zaza
Medullary sponge kidney (MSK) disease, a rare kidney malformation featuring recurrent renal stones and nephrocalcinosis, continues to be diagnosed using expensive and time-consuming clinical/instrumental tests (mainly urography). Currently, no molecular diagnostic biomarkers are available. To identify such we employed a proteomic-based research strategy utilizing urine from 22 patients with MSK and 22 patients affected by idiopathic calcium nephrolithiasis (ICN) as controls. Notably, two patients with ICN presented cysts...
November 30, 2016: Kidney International
https://www.readbyqxmd.com/read/27885825/multiphase-fluid-solid-coupled-analysis-of-shock-bubble-stone-interaction-in-shockwave-lithotripsy
#4
K G Wang
A novel multiphase fluid-solid coupled computational framework is applied to investigate the interaction of a kidney stone immersed in liquid with a lithotripsy shock wave (LSW) and a gas bubble near the stone. The main objective is to elucidate the effects of a bubble in the shock path to the elastic and fracture behaviors of the stone. The computational framework couples a finite volume two-phase computational fluid dynamics (CFD) solver with a finite element (FE) computational solid dynamics (CSD) solver...
November 24, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27861708/high-dose-monthly-vitamin-d-for-prevention-of-acute-respiratory-infection-in-older-long-term-care-residents-a-randomized-clinical-trial
#5
Adit A Ginde, Patrick Blatchford, Keith Breese, Lida Zarrabi, Sunny A Linnebur, Jeffrey I Wallace, Robert S Schwartz
OBJECTIVES: To determine the efficacy and safety of high-dose vitamin D supplementation for prevention of acute respiratory infection (ARI) in older long-term care residents. DESIGN: Randomized controlled trial investigating high-dose vs standard-dose vitamin D from 2010 to 2014. SETTING: Colorado long-term care facilities. PARTICIPANTS: Long-term care residents aged 60 and older (n = 107). INTERVENTION: The high-dose group received monthly supplement of vitamin D3 100,000 IU, the standard-dose group received a monthly placebo (for participants taking 400-1,000 IU/d as part of usual care) or a monthly supplement of 12,000 IU of vitamin D3 (for participants taking <400 IU/d as part of usual care)...
November 16, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27856088/tolvaptan-and-kidney-pain-in-patients-with-autosomal-dominant%C3%A2-polycystic-kidney-disease-secondary-analysis-from%C3%A2-a-randomized-controlled-trial
#6
Niek F Casteleijn, Jaime D Blais, Arlene B Chapman, Frank S Czerwiec, Olivier Devuyst, Eiji Higashihara, Anna M Leliveld, John Ouyang, Ronald D Perrone, Vicente E Torres, Ron T Gansevoort
BACKGROUND: Kidney pain is a common complication in patients with autosomal dominant polycystic kidney disease (ADPKD), and data from the TEMPO 3:4 trial suggested that tolvaptan, a vasopressin V2 receptor antagonist, may have a positive effect on kidney pain in this patient group. Because pain is difficult to measure, the incidence of kidney pain leading to objective medical interventions was used in the present study to assess pain. STUDY DESIGN: Secondary analysis from a randomized controlled trial...
November 14, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27852120/kim-1-is-a-potential-urinary-biomarker-of-obstruction-results-from-a-prospective-cohort-study
#7
Daniel Olvera-Posada, Thamara Dayarathna, Marie Dion, Husain Alenezi, Alp Sener, John D Denstedt, Stephen E Pautler, Hassan Razvi
INTRODUCTION: Partial or complete obstruction of the urinary tract is a common and challenging urological condition that may occur in patients of any age. Serum creatinine is the most commonly used method to evaluate global renal function, although it has low sensitivity for early changes in the glomerular filtration rate or unilateral renal pathology. Hence, finding another measurable parameter that reflects the adaptation of the renal physiology to these circumstances is important. Several recent studies have assessed the use of new biomarkers of Acute Kidney Injury (AKI), but the information among patients with stone disease and those with obstructive uropathy is limited...
November 16, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27844243/analysis-of-chemical-constituents-antimicrobial-and-anticancer-activities-of-dichloromethane-extracts-of-sordariomycetes-sp-endophytic-fungi-isolated-from-strobilanthes-crispus
#8
Elaine Chin Jinfeng, Mohamed Ikhtifar Mohamad Rafi, Khoo Chai Hoon, Ho Kok Lian, Cheah Yoke Kqueen
Plants are primary source of natural product drugs. However, with every new bioactive molecule reported from a plant source, there follows reports of endangered status or even extinction of a medicinally important plant due to over-harvesting. Hence, the attention turned towards fungi namely the endophytes, which reside within medicinally important plants and thus may have acquired their medicinal properties. Strobilanthes crispus is a traditional medicinal plant which has been used traditionally to treat kidney stones, diabetes, hypertension and cancer as well as having antimicrobial activities...
January 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27829958/antioxidant-and-renoprotective-effects-of-mushroom-extract-implication-in-prevention-of-nephrolithiasis
#9
Ariel Schulman, Matthew Chaimowitz, Muhammad Choudhury, Majid Eshghi, Sensuke Konno
BACKGROUND: The pathogenesis of nephrolithiasis (kidney stone) remains elusive, while several therapeutic options are available but not effective as we expected. Accumulating data yet suggest that oxidative stress (generation of oxygen free radicals) may play a primary role in its occurrence. Particularly, calcium oxalate (CaOx) is a key element in the most common form (> 75%) of kidney stones, and its crystal form known as CaOx monohydrate (COM) has been shown to exert oxidative stress, facilitating CaOx stone formation...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27825102/microvillar-injury-in-renal-tubular-epithelial-cells-induced-by-calcium-oxalate-crystal-and-the-protective-role-of-epigallocatechin-3-gallate
#10
Kedsarin Fong-Ngern, Arada Vinaiphat, Visith Thongboonkerd
Pathogenic mechanisms of kidney stone disease remained unclear. This study investigated its initial cellular/molecular mechanisms when calcium oxalate monohydrate (COM) crystal adhered to renal tubular cells. Transmission electron microscopy revealed decreased length and density of microvilli, whereas Western blot analysis showed that whole-cell ezrin (a microvilli-stabilizing protein), not β-actin, was decreased in COM-treated cells. Immunofluorescence staining, followed by laser-scanning confocal microscopy and subcellular fractionations, revealed decreases in both ezrin and F-/β-actin at apical membrane...
October 7, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27824261/extracorporeal-shockwave-lithotripsy-versus-flexible-ureteroscopy-for-the-management-of-upper-tract-urinary-stones-in-children
#11
Lucas Freton, Benoit Peyronnet, Alexis Arnaud, Lauranne Tondut, Juliette Hascoët, Benjamin Pradere, Gregory Verhoest, Edouard Habonimana, Olivier Azzis, Benjamin Fremond, Karim Bensalah
OBJECTIVE: To compare the efficacy and morbidity of extracorporeal shockwave lithotripsy (ESWL) and flexible ureteroscopy (F-URS) for the management of upper urinary tract stones in children. METHODS: All ESWL and F-URS performed in children in a single-institution between 2000 and 2014 were reviewed retrospectively. Only procedures performed to treat upper tract urinary stones (upper ureter or kidney) were included in this study. Preoperative and perioperative outcomes were compared between the ESWL and F-URS groups...
November 8, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27822582/are-there-any-predictors-of-pyonephrosis-in-patients-with-renal-calculus-disease
#12
Madhusudan Patodia, Apul Goel, Vishwajeet Singh, Bhupendra Pal Singh, Rahul Janak Sinha, Manoj Kumar, Divakar Dalela, Satya Narayan Sankhwar
The objective of the study is to identify factors predicting development of pyonephrosis in patients of renal calculus disease (RCD), as this knowledge is largely unknown. Patients of RCD without pyonephrosis (Group 1) or with pyonephrosis (Group 2) presenting between December 2013 and November 2015 were evaluated. All patients of RCD who had undergone either percutaneous nephrostomy (PCN) or surgical management (percutaneous nephrolithotomy/pyelolithotomy/nephrectomy) were included. Patients treated conservatively, by extracorporeal shock-wave lithotripsy and patients of bilateral RCD were excluded...
November 7, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27796334/alpha-enolase-on-apical-surface-of-renal-tubular-epithelial-cells-serves-as-a-calcium-oxalate-crystal-receptor
#13
Kedsarin Fong-Ngern, Visith Thongboonkerd
To search for a strategy to prevent kidney stone formation/recurrence, this study addressed the role of α-enolase on apical membrane of renal tubular cells in mediating calcium oxalate monohydrate (COM) crystal adhesion. Its presence on apical membrane and in COM crystal-bound fraction was confirmed by Western blotting and immunofluorescence staining. Pretreating MDCK cells with anti-α-enolase antibody, not isotype-controlled IgG, dramatically reduced cell-crystal adhesion. Immunofluorescence staining also confirmed the direct binding of purified α-enolase to COM crystals at {121} > {100} > {010} crystal faces...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27793365/comparative-analysis-between-percutaneous-nephrolithotomy-and-flexible-ureteroscopy-in-kidney-stones-of-2-3cm
#14
E Pieras, V Tubau, X Brugarolas, J Ferrutxe, P Pizá
INTRODUCTION: To compare percutaneous nephrolithotomy and flexible ureterorenoscopy for treating kidney stones between 2 and 3cm. MATERIAL AND METHODS: A prospective, comparative, nonrandomised study was conducted with 108 patients with kidney stones between 2 and 3cm. Fifty-four patients underwent percutaneous nephrolithotomy and 54 underwent flexible ureteroscopy. We compared the following variables: lithiasis-free rate (%), surgical time, the need for an auxiliary process, postoperative complications, hospital stay, readmission rates and recovery time...
October 25, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27789299/profile-of-the-ammonium-acid-urate-stone-former-based-on-a-large-contemporary-cohort
#15
Derek J Lomas, Christopher D Jaeger, Amy E Krambeck
OBJECTIVE: To evaluate and profile ammonium acid urate (AAU) stone formers utilizing a large contemporary cohort. MATERIALS AND METHODS: A retrospective review of all patients with documented AAU urolithiasis on stone analysis was performed from 1995 to 2013. A stone was considered AAU if it contained at least 10% of the total composition on stone analysis. RESULTS: Of 12,421 stones, a total of 111 AAU stones were identified in 89 patients...
October 24, 2016: Urology
https://www.readbyqxmd.com/read/27779226/kidney-cancer-classifying-the-unclassified-molecular-analysis-of-urcc
#16
Louise Stone
No abstract text is available yet for this article.
December 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27768022/advantage-of-supine-transgluteal-approach-for-distal-ureteral-stone-extracorporeal-shock-wave-lithotripsy-outcomes-based-on-computerized-tomography-characteristics
#17
Riccardo Galli, Maria C Sighinolfi, Salvatore Micali, Eugenio Martorana, Marco Rosa, Alessando Mofferdin, Giampaolo Bianchi
BACKGROUND: Shock Wave Lithotripsy (SWL) for distal ureteral stones can be performed in prone or supine position. Our aim is to demonstrate the advantage of the supine transgluteal SWL approach for distal ureteral stones treatment using a real times ultrasound (US) focusing and to show how the Computerized Tomography (CT) scan parameters may be related to the outcomes. METHODS: We performed 70 consecutive supine transgluteal SWL of distal ureteral stones. All patients had a pre-treatment CT scan...
October 21, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27765695/vitamin-d-repletion-in-kidney-stone-formers-a-randomized-controlled-trial
#18
Matthew C Ferroni, Kevin J Rycyna, Timothy D Averch, Michelle J Semins
PURPOSE: Vitamin D deficiency is often detected during metabolic evaluation in the nephrolithiasis population. Multiple vitamin D repletion protocols exist, however their differing impact on urinary stone formation risk factors is unclear. MATERIALS AND METHODS: Patients with a history of calcium stones and vitamin D deficiency (<30ng/ml) were randomized to receive either 1,000 International Units (IU) daily or 50,000 IU weekly of vitamin D supplementation for 6 weeks...
October 17, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27756957/effect-of-hydro-alcoholic-extract-of-vernonia-cinerea-less-against-ethylene-glycol-induced-urolithiasis-in-rats
#19
Ravindra D Hiremath, Sunil S Jalalpure
OBJECTIVE: Aim of this study is to evaluate antiurolithiatic potential of whole plant hydro-alcoholic (30:70) extract of Vernonia cinerea Less. in accordance to its claims made in ancient literature and also being one of the ingredients of cystone, a marketed formulation widely used in the management of urolithiasis. MATERIALS AND METHODS: To induce urolithiasis, 0.75% v/v ethylene glycol was administered orally for 14 days. The curative dose of 400 mg/kg b.w. and preventive doses of 100, 200, and 400 mg/kg b...
July 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27748900/analysis-of-altered-microrna-expression-profiles-in-the-kidney-tissues-of-ethylene-glycol-induced-hyperoxaluric-rats
#20
Zhuo Liu, Hongyang Jiang, Jun Yang, Tao Wang, Yufeng Ding, Jihong Liu, Shaogang Wang, Zhangqun Ye
Calcium oxalate stones account for >80% of urinary stones, however the mechanisms underlying their formation remains to be elucidated. Hyperoxaluria serves an important role in the pathophysiological process of stone formation. In the present study, differences in the miRNA expression profiles between experimental hyperoxaluric rats and normal rats were analyzed, in order to identify target genes and signaling pathways involved in the pathogenesis of hyperoxaluria. Ethylene glycol and ammonium chloride was fed to male hyperoxaluric rats (EXP) and normal age‑matched male rats (CON)...
November 2016: Molecular Medicine Reports
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