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Kidney stone analysis

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https://www.readbyqxmd.com/read/29338314/inflammatory-cytokines-in-the-papillary-tips-and-urine-of-nephrolithiasis-patients
#1
Andrew Yang Sun, Bryan Hinck, Benjamin R Cohen, Karen Keslar, Robert L Fairchild, Manoj Monga
INTRODUCTION: Intrarenal inflammation has been implicated in the pathogenesis of nephrolithiasis, with prior work showing increased urine levels of IL-6, IL-8, and CCL-2 in stone patients. However, no studies have assessed for inflammation in the renal papillae. We sought to characterize novel papillary tip and urinary biomarkers in stone patients. METHODS: 92 patients with nephrolithiasis undergoing percutaneous nephrolithotomy were enrolled. Papillary tip biopsies, kidney urine, and bladder urine were collected, as well as voided urine from 8 healthy volunteers...
January 16, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29335063/tea-consumption-is-associated-with-increased-risk-of-kidney-stones-in-northern-chinese-a-cross-sectional-study
#2
Zhong Biao Wu, Tian Jiang, Guo Bing Lin, You Xin Wang, Yong Zhou, Zhen Qian Chen, Yong Ming Xu, Hai Bo Ye, Bo Jun Chen, Xiao Zhao Bao, Cun Ming Zhang
Kidney stones are a common urinary system condition that can progress to kidney disease. Previous studies on the association between tea consumption and kidney stones are inconsistent. A cross-sectional study to investigate the association between tea consumption and kidney stones was conducted from 2013 to 2014 and recruited 9,078 northern Chinese adults. A total of 8,807 participants were included in the final analysis. Participants' prevalence of kidney stones was 1.07%, 1.73%, and 2.25% based on their tea consumption frequency of never, occasionally, and often groups, respectively...
December 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29333512/fourier-transform-infrared-spectroscopy-for-analysis-of-kidney-stones
#3
Aysha Habib Khan, Sheharbano Imran, Jamsheer Talati, Lena Jafri
Purpose: To compare the results of a chemical method of kidney stone analysis with the results of Fourier transform infrared (FT-IR) spectroscopy. Materials and Methods: Kidney stones collected between June and October 2015 were simultaneously analyzed by chemical and FT-IR methods. Results: Kidney stones (n=449) were collected from patients from 1 to 81 years old. Most stones were from adults, with only 11.5% from children (aged 3-16 years) and 1...
January 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29304995/meta-analysis-of-culprit-only-versus-multivessel-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-coronary-disease
#4
Sripal Bangalore, Bora Toklu, Gregg W Stone
Recently, several randomized controlled trials (RCT) in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD) have compared a strategy of routine multivessel percutaneous coronary intervention (PCI) performed either as a single procedure or as staged procedures to culprit-only PCI. All of these trials have been underpowered for clinical end points. We searched PubMed, Embase, and Cochrane Central Register of Controlled Trials for RCT comparing multivessel PCI with culprit-only PCI in patients with STEMI and MVD...
December 12, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29279874/calcium-tartrate-tetrahydrate-case-report-of-a-novel-human-kidney-stone
#5
Colin Kleinguetl, James C Williams, Samar A Ibrahim, Michel Daudon, Erin T Bird, Marawan M El Tayeb
Background: Calcium tartrate tetrahydrate has been reported as the main mineral in urinary stones in rats that have significant tartrate in their diet, but in humans, there has been only one mention of calcium tartrate stones in the form of bladder stone, and that case was in Africa. Case Presentation: Patient is a 34-year-old Caucasian male who presented with typical symptoms of nephrolithiasis. CT abd/pelvis (renal stone protocol) revealed a 2 cm nonobstructing stone of the right renal pelvis. Patient underwent an uncomplicated right percutaneous nephrolithotomy and was noted to be stone free after surgery...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29277886/the-respiratory-induced-kidney-motion-does-it-really-effect-the-shock-wave-lithotripsy
#6
Mehmet Ozgur Yucel, Serkan Ozcan, Gokhan Tirpan, Murat Bagcioglu, Arif Aydin, Arif Demirbas, Tolga Karakan
PURPOSE: To investigate the effect of respiratory induced kidney mobility on success of shock wave lithotripsy (SWL) with an electrohydraulic lithotripter. MATERIALS AND METHODS: Between May 2013 and April 2015, 158 patients underwent SWL treatment for kidney stones with an electrohydraulic lithotripter. The exclusion criteria were presence of a known metabolic disease (such as cystinuria), non-opaque stones, need for focusing with ultrasonography, abnormal habitus, urinary tract abnormalities, and inability to tolerate SWL until the end of the procedure...
December 25, 2017: Urology Journal
https://www.readbyqxmd.com/read/29275531/renal-phosphate-handling-and-inherited-disorders-of-phosphate-reabsorption-an-update
#7
REVIEW
Carsten A Wagner, Isabel Rubio-Aliaga, Nati Hernando
Renal phosphate handling critically determines plasma phosphate and whole body phosphate levels. Filtered phosphate is mostly reabsorbed by Na+-dependent phosphate transporters located in the brush border membrane of the proximal tubule: NaPi-IIa (SLC34A1), NaPi-IIc (SLC34A3), and Pit-2 (SLC20A2). Here we review new evidence for the role and relevance of these transporters in inherited disorders of renal phosphate handling. The importance of NaPi-IIa and NaPi-IIc for renal phosphate reabsorption and mineral homeostasis has been highlighted by the identification of mutations in these transporters in a subset of patients with infantile idiopathic hypercalcemia and patients with hereditary hypophosphatemic rickets with hypercalciuria...
December 23, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29249291/a-multigene-signature-based-on-cell-cycle-proliferation-improves-prediction-of-mortality-within-5-yr-of-radical-nephrectomy-for-renal-cell-carcinoma
#8
Todd M Morgan, Rohit Mehra, Placede Tiemeny, J Stuart Wolf, Shulin Wu, Zaina Sangale, Michael Brawer, Steven Stone, Chin-Lee Wu, Adam S Feldman
BACKGROUND: There is a critical need for improved prognostic discrimination in patients with renal cell carcinoma (RCC) given the increasing awareness that some patients may be managed with active surveillance, while others with higher-risk disease might benefit from adjuvant therapy following surgery. OBJECTIVE: To determine whether a multigene proliferation signature predicts long-term oncologic outcomes in surgically resected RCC. DESIGN, SETTING, AND PARTICIPANTS: The cell cycle proliferation (CCP) score was determined after radical nephrectomy for localized clear cell, papillary, or chromophobe RCC in 565 patients...
December 14, 2017: European Urology
https://www.readbyqxmd.com/read/29239240/applications-of-mid-infrared-spectroscopy-in-the-clinical-laboratory-setting
#9
Sander De Bruyne, Marijn M Speeckaert, Joris R Delanghe
Fourier transform mid-infrared (MIR-FTIR) spectroscopy is a nondestructive, label-free, highly sensitive and specific technique that provides complete information on the chemical composition of biological samples. The technique both can offer fundamental structural information and serve as a quantitative analysis tool. Therefore, it has many potential applications in different fields of clinical laboratory science. Although considerable technological progress has been made to promote biomedical applications of this powerful analytical technique, most clinical laboratory analyses are based on spectroscopic measurements in the visible or ultraviolet (UV) spectrum and the potential role of FTIR spectroscopy still remains unexplored...
December 14, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29234242/role-of-molecular-recognition-in-l-cystine-crystal-growth-inhibition
#10
Laura N Poloni, Zina Zhu, Nelson Garcia-Vázquez, Anthony C Yu, David M Connors, Longqin Hu, Amrik Sahota, Michael D Ward, Alexander G Shtukenberg
l-Cystine kidney stones-aggregates of single crystals of the hexagonal form of l-cystine-afflict more than 20 000 individuals in the United States alone. Current therapies are often ineffective and produce adverse side effects. Recognizing that the growth of l-cystine crystals is a critical step in stone pathogenesis, real-time in situ atomic force microscopy of growth on the (0001) face of l-cystine crystals and measurements of crystal growth anisotropy were performed in the presence of prospective inhibitors drawn from a 31-member library...
May 3, 2017: Crystal Growth & Design
https://www.readbyqxmd.com/read/29218471/rural-environment-study-for-water-from-different-sources-in-cluster-of-villages-in-mehsana-district-of-gujarat
#11
Nitasha Khatri, Sanjiv Tyagi, Deepak Rawtani
Water pollution and water scarcity are major environmental issues in rural and urban areas. They lead to decline in the quality of water, especially drinking water. Proper qualitative assessment of water is thus necessary to ensure that the water consumed is potable. This study aims to analyze the physicochemical parameters in different sources of water in rural areas and assess the quality of water through a classification system based on BIS and CPCB standards. The classification method has defined water quality in six categories, viz...
December 7, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29212373/propensity-score-matched-analysis-comparing-retrograde-intrarenal-surgery-with-percutaneous-nephrolithotomy-for-large-stones-in-patients-with-a-solitary-kidney
#12
Xiaolei Shi, Yonghan Peng, Xiao Li, Qi Wang, Ling Li, Min Liu, Xiaofeng Gao, Yinghao Sun
PURPOSES: To evaluate the clinical efficacy, safety, and cost of retrograde intrarenal surgery (RIRS) and percutaneous nephrolithotomy (PCNL) in the treatment for large renal stones in patients with a solitary kidney. PATIENTS AND METHODS: In this study, 117 patients with a solitary kidney who had undergone PCNL or RIRS for renal stones larger than 2 cm between January 2010 and December 2016 were retrospectively evaluated. The patients' demographic data, clinical characteristics, and perioperative outcomes were collected through a review of their medical records...
December 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29207740/risk-factors-for-kidney-stones-in-rural-puducherry-case-control-study
#13
Amol R Dongre, M Rajalakshmi, Pradeep R Deshmukh, M R Thirunavukarasu, Ravi Kumar
Introduction: Renal stone is a distressing chronic condition which is getting common across the world. The rigorous evidence on multiple risk factors of kidney stone from a single study is limited. Aim: To find out the social and dietary risk factors responsible for the occurrence of kidney stone in a local community in rural Puducherry, India. Materials and Methods: It was a hospital-based unmatched case-control study. Based on existing information, a sample of 70 cases and 140 controls was calculated and considered adequate...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204517/proteomic-analysis-of-aqp11-null-kidney-proximal-tubular-type-polycystic-kidney-disease
#14
Tatsuya Saito, Yasuko Tanaka, Yoshiyuki Morishita, Kenichi Ishibashi
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is caused by the mutation of polycystins (PC-1 or PC-2), in which cysts start from the collecting duct to extend to all nephron segments with eventual end stage renal failure. The cyst development is attenuated by a vasopressin V2 receptor antagonist tolvaptan which, however, will not affect proximal tubule cysts devoid of V2 receptor. Aquaporin-11 (AQP11) is expressed selectively in the proximal tubule of the kidney and AQP11-null kidneys have a disruptive PC-1 trafficking to the plasma membrane to develop polycystic kidneys...
March 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29201513/comparison-of-the-outcomes-of-complete-supine-percutaneous-nephrolithotomy-in-patients-with-radiopaque-and-radiolucent-kidney-stones
#15
Siavash Falahatkar, Gholamreza Mokhtari, Atiyeh Amin, Ehsan Kazemnezhad, Samaneh Esmaeili, Nadia Rastjou Herfeh, Reza Falahatkar
Objective: This study compared the stone opacity effect in patients who had radiopaque and radiolucent stones in percutaneous nephrolithotomy (PCNL) results. Material and methods: The medical records of 171 complete supine PCNL procedures were gathered. Patients were categorized into two groups: those with radiopaque (n=141) and those with radiolucent (n=30) stones. Kidney, ureter and bladder x-ray was done a day after PCNL and Ultrasound imaging was done two weeks later to evaluate the stone free rate...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29196385/characteristic-and-outcome-of-psoriatic-arthritis-patients-with-hyperuricemia
#16
Roa'A AlJohani, Ari Polachek, Justine Yang Ye, Vinod Chandran, Dafna D Gladman
OBJECTIVE: To determine the characteristics of patients with psoriatic arthritis (PsA) who have hyperuricemia (HUC) and their outcomes, especially cardiovascular (CVD) and kidney diseases. METHODS: Patients have been followed prospectively at the PsA clinic according to a standard protocol at 6- to 12-month intervals. We defined HUC in men > 450 μmol/l or women > 360 μmol/l. We matched patients with HUC based on sex and age ± 5 years with normal uric acid patients...
December 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29191630/efficacy-and-safety-of-bivalirudin-in-coronary-artery-disease-patients-with-mild-to-moderate-chronic-kidney-disease-meta-analysis
#17
Xiaofang Zeng, A Michael Lincoff, Stefanie Schulz-Schüpke, Philippe Gabriel Steg, Yedid Elbez, Roxana Mehran, Gregg W Stone, Thomas McAndrew, Jianhui Lin, Xindan Zhang, Wenhai Shi, Han Lei, Zhicheng Jing, Wei Huang
BACKGROUND: Patients with chronic kidney disease (CKD) have elevated bleeding and ischemic outcomes. We aim to assess the short- and long-term efficacy and safety of bivalirudin compared to heparin plus glycoprotein IIb/IIIa inhibitors (GPIs) in coronary artery disease (CAD) patients with CKD. METHODS: Randomized trials were searched in PubMed, Cochrane, and Embase databases up to January 2017. Among the trials retrieved, efficacy endpoints were defined as mortality, myocardial infarction (MI), repeat revascularization, stent thrombosis, and major adverse cardiac events (MACEs)...
November 27, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29181209/ureteropelvic-junction-obstruction-and-parathyroid-adenoma-coincidence-or-link
#18
Salah Termos, Majd AlKabbani, Tim Ulinski, Sami Sanjad, Henri Kotobi, Francois Chalard, Bilal Aoun
Congenital ureteropelvic junction obstruction (UPJO) is the most common cause of upper urinary tract obstruction in children. It is generally diagnosed in the routine work-up during antenatal period and is characterized by spontaneous recovery. It can be associated with urolithiasis; hence further investigation should be carried out. We report the case of a 15-year-old boy, who is known to have right UPJO, presented with right renal colic and discovered to have bilateral kidney stones. Further studies showed primary hyperparathyroidism and genetic analysis revealed a CDC73 mutation (initially HRPT2)...
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/29179855/analysis-of-the-influence-of-the-t393c-polymorphism-of-the-gnas-gene-on-the-clinical-expression-of-primary-hyperparathyroidism
#19
María Piedra, Ana Berja, Laura Ramos, María Teresa García-Unzueta, Jesús Manuel Morán, David Ruiz, José Antonio Amado
BACKGROUND: The receptor of parathyroid hormone and parathyroid hormone-related-protein (PTH/PTHrp) is located in the cell membrane of target tissues - kidney and osteoblasts. It is a G protein-coupled-receptor whose Gsα subunit is encoded by the GNAS gene. Our aim was to study whether the single nucleotide polymorphism (SNP) T393C of the GNAS gene is associated with renal stones, bone mineral density (BMD), or bone remodelling markers in primary hyperparathyroidism (PHPT). METHODS: An analysis was made of clinical and biochemical parameters and densitometric values in three areas and their relationship with the T393C SNP of the GNAS gene in 261 patients with primary hyperparathyroidism and in 328 healthy controls...
December 2017: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29179563/clinical-outcomes-for-cystinuria-patients-with-unilateral-versus-bilateral-cystine-stone-disease
#20
Manint Usawachintachit, Benjamin Sherer, Matthew Hudnall, David T Tzou, Kazumi Taguchi, Ryan S Hsi, Marshall Stoller, Thomas Chi
<b>Introduction</b>: Cystinuria is a genetic disorder marked by elevated urinary cystine excretion and recurrent cystine nephrolithiasis. Interestingly, despite seemingly similar contralateral renal anatomy, a subset of cystinuric patients consistently form stones in only one kidney. The aim of this study is to evaluate clinical outcomes in unilateral versus bilateral cystine stone formers. <b>Methods</b>: We performed a retrospective case-control study of cystinuric patients evaluated and treated at the University of California, San Francisco between 1994 and 2015 and categorized patients as either unilateral or bilateral stone formers...
November 27, 2017: Journal of Endourology
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