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Kupffer cell

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https://www.readbyqxmd.com/read/29156799/asiatic-acid-protects-against-hepatic-ischemia-reperfusion-injury-by-inactivation-of-kupffer-cells-via-ppar%C3%AE-nlrp3-inflammasome-signaling-pathway
#1
Ying Xu, Jun Yao, Chen Zou, Heng Zhang, Shouliang Zhang, Jun Liu, Gui Ma, Pengcheng Jiang, Wenbo Zhang
Hepatic ischemia/reperfusion (I/R) contributes to major complications in clinical practice affecting perioperative morbidity and mortality. Recent evidence suggests the key role of nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammaosme activation on the pathogenesis of I/R injury. Asiatic acid (AA) is a pentacyclic triterpene derivative presented with versatile activities, including antioxidant, anti-inflammation and hepatoprotective effects. This study was designed to determine whether AA had potential hepatoprotective benefits against hepatic I/R injury, as well as to unveil the underlying mechanisms involved in the putative effects...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151327/serum-matrix-metalloproteinase-1-level-represents-disease-activity-as-opposed-to-fibrosis-in-patients-with-histologically-proven-nonalcoholic-steatohepatitis
#2
Wataru Ando, Hiroaki Yokomori, Nobuhiro Tsutsui, Eigoro Yamanouchi, Yutaka Suzuki, Masaya Oda, Yutaka Inagaki, Katsuya Otori, Isao Okazaki
Background/Aims: Nonalcoholic steatohepatitis (NASH) is prevalent in both economically developed and developing countries. Twenty percent of NASH progresses to cirrhosis with/without hepatocellular carcinoma, and there is an urgent need to find biomarkers for early diagnosis and monitoring progression of the disease. Using immunohistochemical and immunoelectron microscopic examination we previously reported that expression of matrix metalloproteinase-1 (MMP-1) increased in monocytes, Kupffer cells and hepatic stellate cells in early stage NASH...
November 20, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29150769/changes-in-expression-of-the-membrane-receptors-cd14-mhc-ii-sr-a-and-tlr4-in-tissue-specific-monocytes-macrophages-following-porphyromonas-gingivalis-lps-stimulation
#3
Chunfang Wu, Chongwu Liu, Kai Luo, Yanfen Li, Jun Jiang, Fuhua Yan
The aim of the study was to provide a theoretical foundation for understanding the relationship between periodontal diseases and systemic diseases by examining the inflammatory effect of Porphyromonas gingivalis lipopolysaccharide (LPS) on monocytes/macrophages isolated from tissues distinct from the oral cavity in normal and hyperlipidemic New Zealand white rabbits. Macrophages were isolated from four separate tissues (mononuclear cells from blood, alveolar macrophages, peritoneal macrophages, and Kupffer cells) from both normal and hyperlipidemic New Zealand white rabbits...
November 18, 2017: Inflammation
https://www.readbyqxmd.com/read/29142263/hyaluronic-acid-35-normalizes-tlr4-signaling-in-kupffer-cells-from-ethanol-fed-rats-via-regulation-of-microrna291b-and-its-target-tollip
#4
Paramananda Saikia, Sanjoy Roychowdhury, Damien Bellos, Katherine A Pollard, Megan R McMullen, Rebecca L McCullough, Arthur J McCullough, Pierre Gholam, Carol de la Motte, Laura E Nagy
TLR4 signaling in hepatic macrophages is increased after chronic ethanol feeding. Treatment of hepatic macrophages after chronic ethanol feeding with small-specific sized hyaluronic acid 35 (HA35) normalizes TLR4 signaling; however, the mechanisms for HA35 action are not completely understood. Here we used Next Generation Sequencing of microRNAs to identify negative regulators of TLR4 signaling reciprocally modulated by ethanol and HA35 in hepatic macrophages. Eleven microRNAs were up-regulated by ethanol; only 4 microRNAs, including miR291b, were decreased by HA35...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29140250/gdf3-is-required-for-robust-nodal-signaling-during-germ-layer-formation-and-left-right-patterning
#5
Jose L Pelliccia, Granton A Jindal, Rebecca D Burdine
Vertebrate embryonic patterning depends on signaling from Nodal, a TGFβ superfamily member. There are three Nodal orthologs in zebrafish; southpaw directs left-right asymmetries, while squint and cyclops function earlier to pattern mesendoderm. TGFβ member Vg1 is implicated in mesoderm formation but the role of the zebrafish ortholog, Growth differentiation factor 3 (Gdf3), has not been fully explored. We show that zygotic expression of gdf3 is dispensable for embryonic development, while maternally deposited gdf3 is required for mesendoderm formation and dorsal-ventral patterning...
November 15, 2017: ELife
https://www.readbyqxmd.com/read/29132049/male-syrian-hamsters-are-more-susceptible-to-intravenous-infection-with-species-c-human-adenoviruses-than-are-females
#6
Baoling Ying, Jacqueline F Spencer, Ann E Tollefson, William S M Wold, Karoly Toth
Recently, increasing attention has been focused on the influence of sex on the course of infectious diseases. Thus far, the best-documented examples point toward an immune-mediated mechanism: the generally stronger immune response in females can result in a faster clearance of the pathogen or, conversely, a more severe immune-mediated pathology. Here, we report that human species C adenoviruses replicate more and cause more pathology in male Syrian hamsters than in females. We also show that this sex disparity is not caused by a stronger immune response to the infection by the female hamsters...
November 10, 2017: Virology
https://www.readbyqxmd.com/read/29129664/hemistepsin-a-ameliorates-acute-inflammation-in-macrophages-via-inhibition-of-nuclear-factor-%C3%AE%C2%BAb-and-activation-of-nuclear-factor-erythroid-2-related-factor-2
#7
Jae Kwang Kim, Ji Eun Lee, Eun Hye Jung, Ji Yun Jung, Dae Hwa Jung, Sae Kwang Ku, Il Je Cho, Sang Chan Kim
Hemistepsin A (HsA) is a sesquiterpene lactone isolated from Hemistepta lyrata (Bunge) Bunge. We investigated the anti-inflammatory effects of HsA and sought to determine its mechanisms of action in macrophages. HsA pretreatment inhibited nitric oxide production, and reduced the expression of iNOS and COX-2 in Toll-like receptor ligand-stimulated RAW 264.7 cells. Additionally, HsA decreased the secretion of proinflammatory cytokines in lipopolysaccharide (LPS)-stimulated Kupffer cells as well as in RAW 264...
November 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29129239/an-iso-%C3%AE-acid-rich-extract-from-hops-humulus-lupulus-attenuates-acute-alcohol-induced-liver-steatosis-in-mice
#8
Marianne Hege, Finn Jung, Cathrin Sellmann, Chengjun Jin, Doreen Ziegenhardt, Claus Hellerbrand, Ina Bergheim
OBJECTIVE: Results of in vitro and in vivo studies suggest that consumption of beer is less harmful for the liver than consumption of spirits. It also has been suggested that secondary plant compounds derived from hops such as xanthohumol or iso-α-acids may have beneficial effects on the development of liver diseases of various etiologies. The aim of this study was to determine whether iso-α-acids consumed in doses achieved by "normal" beer consumption have beneficial effects on health...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29127992/leishmania-infantum-exerts-immunomodulation-in-canine-kupffer-cells-reverted-by-meglumine-antimoniate
#9
A Rodrigues, D Santos-Mateus, G Alexandre-Pires, A Valério-Bolas, M Rafael-Fernandes, M A Pereira, D Ligeiro, J de Jesus, R Alves-Azevedo, S Lopes-Ventura, M Santos, A M Tomás, I Pereira da Fonseca, G Santos-Gomes
Kupffer cells (KC) are the liver macrophage population that resides in the hepatic sinusoids and efficiently phagocyte pathogens by establishing an intimate contact with circulating blood. KC constitute the liver host cells in Leishmania infection, nevertheless little is described about their role, apart from their notable contribution in granulomatous inflammation. The present study aims to investigate how canine KC sense and react to the presence of Leishmania infantum promastigotes and amastigotes by evaluating the gene expression of specific innate immune cell receptors and cytokines, as well as the induction of nitric oxide and urea production...
December 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/29121675/astaxanthin-prevents-ischemia-reperfusion-injury-of-the-steatotic-liver-in-mice
#10
Shaowei Li, Terumi Takahara, Masayuki Fujino, Yasuyuki Fukuhara, Toshiro Sugiyama, Xiao-Kang Li, Shiro Takahara
Steatosis has a low tolerance against ischemia-reperfusion injury (IRI). To prevent IRI in the steatotic liver, we attempted to elucidate the protective effect of astaxanthin (ASTX) in the steatotic liver model by giving mice a methionine and choline-deficient high fat (MCDHF) diet. Levels of lipid peroxidation and apoptosis, the expression of inflammatory cytokines and heme oxygenase (HO)-1, in the liver were assessed. Reactive oxygen species (ROS), inflammatory cytokines, apoptosis-related proteins and members of the signaling pathway were also examined in isolated Kupffer cells and/or hepatocytes from the steatotic liver...
2017: PloS One
https://www.readbyqxmd.com/read/29120853/ultrastructural-characteristics-of-the-respective-forms-of-hepatic-stellate-cells-in-chronic-hepatitis-b-as-an-example-of-high-fibroblastic-cell-plasticity-the-first-assessment-in-children
#11
Joanna Maria Lotowska, Maria Elzbieta Sobaniec-Lotowska, Dariusz Marek Lebensztejn
PURPOSE: Activation of hepatic stellate cells (HSCs), mainly responsible for extracellular matrix synthesis, is assumed to be central event in the process of liver fibrogenesis. The major objective of the research was to analyze the ultrastructural profile of activated HSCs in children with chronic hepatitis B (chB), with respect to fibrosis intensity. MATERIALS/METHODS: Ultrastructural investigations of HSCs were conducted on liver bioptates from 70 children with clinicopathologically diagnosed chB before antiviral treatment...
November 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29118246/serum-iga-immune-complexes-promote-proinflammatory-cytokine-production-by-human-macrophages-monocytes-and-kupffer-cells-through-fc%C3%AE-ri-tlr-cross-talk
#12
Ivo S Hansen, Willianne Hoepel, Sebastiaan A J Zaat, Dominique L P Baeten, Jeroen den Dunnen
IgA is predominantly recognized to play an important role in host defense at mucosal sites, where it prevents invasion of pathogens by neutralization. Although it has recently become clear that IgA also mediates other immunological processes, little remains known about the potential of IgA to actively contribute to induction of inflammation, particularly in nonmucosal organs and tissues. In this article, we provide evidence that immune complex formation of serum IgA plays an important role in orchestration of inflammation in response to pathogens at various nonmucosal sites by eliciting proinflammatory cytokines by human macrophages, monocytes, and Kupffer cells...
November 8, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29117209/persistence-of-hepatitis-e-virus-in-the-liver-of-non-viremic-naturally-infected-wild-boar
#13
María A Risalde, Antonio Rivero-Juárez, Fernando Romero-Palomo, Mario Frías, Pedro López-López, David Cano-Terriza, Ignacio García-Bocanegra, Saúl Jiménez-Ruíz, Ángela Camacho, Isabel Machuca, José C Gomez-Villamandos, Antonio Rivero
Hepatitis E virus (HEV) is an emerging zoonotic pathogen with pigs and wild boar serving as reservoirs for human infection through direct contact with infected animals or the consumption of raw or undercooked pork products. The liver is considered the main target site of HEV replication in swine and an important organ in the pathogenesis of the disease. The aim of this study was to characterize the target liver cells for HEV entry in naturally infected wild boar and to evaluate the type and severity of the pathological changes in order to reach a better understanding of the hepatic pathogenic mechanisms involved in hepatitis E...
2017: PloS One
https://www.readbyqxmd.com/read/29112771/role-of-mitochondria-and-mitochondria-targeted-agents-in-non-alcoholic-fatty-liver-disease
#14
REVIEW
Thekkuttuparambil Ananthanarayanan Ajith
Mitochondria play a pivotal role in the fatty acid oxidation and have been found to be affected early during the macrovesicular fat accumulation in the hepatocytes. The fatty infiltration is the primary cause of oxidative stress and inflammation in the non-alcoholic fatty liver disease (NAFLD), which can lead to the peroxidation of phospholipids, such as cardiolipin. Oxidative stress-induced damage to mitochondrial DNA can result in the impairment of oxidative phosphorylation and further increases the generation of reactive oxygen species...
November 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29111158/non-alcoholic-steatohepatitis-induces-transient-changes-within-the-liver-macrophage-pool
#15
Lindsey Devisscher, Charlotte L Scott, Sander Lefere, Sarah Raevens, Eliene Bogaerts, Annelies Paridaens, Xavier Verhelst, Anja Geerts, Martin Guilliams, Hans Van Vlierberghe
Kupffer cells (KCs) and monocyte-derived macrophages are implicated in non-alcoholic steatohepatitis (NASH) pathogenesis but their functions remain unclear due to the lack of specific markers to distinguish between the different cell types. Additionally, it is unclear if multiple subsets of KCs are present during NASH. Here, we characterized the liver macrophage subsets during methionine/choline deficient (MCD) diet-induced NASH and recovery. We observed a significant reduced contribution of Ly6C(lo)Clec4F(+)Tim4(+)KCs to the hepatic macrophage pool in MCD fed mice, which normalized during recovery...
October 16, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29107297/decreasing-cb1-receptor-signaling-in-kupffer-cells-improves-insulin-sensitivity-in-obese-mice
#16
Tony Jourdan, Sarah M Nicoloro, Zhou Zhou, Yuefei Shen, Jie Liu, Nathan J Coffey, Resat Cinar, Grzegorz Godlewski, Bin Gao, Myriam Aouadi, Michael P Czech, George Kunos
OBJECTIVE: Obesity-induced accumulation of ectopic fat in the liver is thought to contribute to the development of insulin resistance, and increased activity of hepatic CB1R has been shown to promote both processes. However, lipid accumulation in liver can be experimentally dissociated from insulin resistance under certain conditions, suggesting the involvement of additional mechanisms. Obesity is also associated with pro-inflammatory changes which, in turn, can promote insulin resistance...
November 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29105340/hepatic-iron-overload-in-the-portal-tract-predicts-poor-survival-in-hepatocellular-carcinoma-after-curative-resection
#17
Jung Wha Chung, Eun Shin, Haeryoung Kim, Ho-Seong Han, Jai Young Cho, Young Rok Choi, Sukho Hong, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong
BACKGROUND & AIMS: Hepatic iron overload is associated with liver injury and hepatocarcinogenesis; however, it has not been evaluated in patients with hepatocellular carcinoma (HCC) in Asia. The aim of this study was to clarify the degree and distribution of intrahepatic iron deposition, and their effects on the survival of HCC patients. METHODS: Intrahepatic iron deposition was examined using non-tumorous liver tissues from 204 HCC patients after curative resection, and they were scored by 2 semi-quantitative methods: simplified Scheuer's and modified Deugnier's methods...
November 4, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29104778/change-in-the-content-of-immunoproteasomes-and-macrophages-in-rat-liver-at-the-induction-of-donor-specific-tolerance
#18
Ya D Karpova, V D Ustichenko, N M Alabedal'karim, A A Stepanova, Yu V Lyupina, K I Boguslavski, G A Bozhok, N P Sharova
Induction of donor specific tolerance (DST) by the introduction of donor cells into a recipient's portal vein is one of the approaches used to solve the problem of transplant engraftment. However, the mechanism of DST development remains unclear to this moment. In the present work, we first studied the change in the content of immunoproteasomes and macrophages of the liver at early stages of the development of allospecific portal tolerance in rats by Western blotting and flow cytofluorimetry. On the basis of the data obtained, we can conclude that the induction of DST is an active process characterized by two phases during which the level of the proteasome immune subunits LMP2 and LMP7 in liver mononuclear cells, including Kupffer cells, and the number of Kupffer cells change...
July 2017: Acta Naturae
https://www.readbyqxmd.com/read/29101679/simple-and-quick-method-to-obtain-a-decellularized-functional-liver-bioscaffold
#19
Matteo Ghiringhelli, Alessandro Zenobi, Stefano Brizzola, Fulvio Gandolfi, Valentino Bontempo, Sandro Rossi, Tiziana A L Brevini, Fabio Acocella
The development of new approaches for organ transplantation has become crucial in the last years. In particular, organ engineering, involving the preparation of acellular matrices that provide a natural habitat for reseeding with an appropriate population of cells, is an attractive although technically demanding approach. We here describe a method that allows for the derivation of functional in vitro hepatic organoids and that does not require a previous selection of all the parenchymal hepatocytes and non-parenchymal cells, namely, Kupffer cells, liver endothelial cells, and hepatic stellate cells...
November 4, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29101207/the-ferroportin-disease-pathogenesis-diagnosis-and-treatment
#20
Antonello Pietrangelo
The Ferroportin Disease is an autosomal dominant hereditary iron loading disorder associated with heterozygote mutations of the ferroportin-1 (FPN) gene. It represents one of commonest cause of genetic hyperferritinemia, regardless of ethnicity. FPN1 transfers iron from the intestine, macrophages and placenta into the bloodstream. In the ferroportin disease, loss-of-function mutations of FPN1 limit but do not impair iron-export in enterocytes, but severely affects iron-transfer in macrophages. This leads to progressive and preferential iron trapping in tissue macrophages, reduced iron release to serum transferrin (i...
November 3, 2017: Haematologica
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