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Kupffer cell

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https://www.readbyqxmd.com/read/28931917/exercise-training-enhances-in-vivo-clearance-of-endotoxin-and-attenuates-inflammatory-responses-by-potentiating-kupffer-cell-phagocytosis
#1
Shoichi Komine, Kentaro Akiyama, Eiji Warabi, Sechang Oh, Keisuke Kuga, Kazunori Ishige, Shinji Togashi, Toru Yanagawa, Junichi Shoda
The failure of Kupffer cells (KCs) to remove endotoxin is an important factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In this study, the effects of exercise training on KC function were studied in terms of in vivo endotoxin clearance and inflammatory responses. Mice were allocated into rest and exercise groups. KC bead phagocytic capacity and plasma steroid hormone levels were determined following exercise training. Endotoxin and inflammatory cytokine levels in plasma were determined over time following endotoxin injection...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28930842/type-4b-hereditary-hemochromatosis-associated-with-a-novel-mutation-in-the-slc40a1-gene-a-case-report-and-a-review-of-the-literature
#2
Wei Zhang, Tingxia Lv, Jian Huang, Xiaojuan Ou
RATIONALE: Hereditary hemochromatosis can be divided into HFE- and non-HFE-related based on genetic mutations in different genes. HFE-related hemochromatosis is the most common inherited genetic disease in European populations but rare in Asia-pacific region. Recently, non-HFE-related hemochromatosis has been reported in patients from the Asian countries. PATIENT CONCERNS: We report the case of a 48-year-old Chinese Han woman who presented with abnormal liver function, diabetes mellitus, hyperferritinemia, and high transferrin saturation, with severe iron overload in parenchymal cells, Kupffer cells, and periportal fibrosis on liver biopsy...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28920945/neutrophils-a-cornerstone-of-liver-ischemia-and-reperfusion-injury
#3
Thiago Henrique Caldeira de Oliveira, Pedro Elias Marques, Paul Proost, Mauro Martins M Teixeira
Ischemia-reperfusion injury (IRI) is the main cause of morbidity and mortality due to graft rejection after liver transplantation. During IRI, an intense inflammatory process occurs in the liver. This hepatic inflammation is initiated by the ischemic period but occurs mainly during the reperfusion phase, and is characterized by a large neutrophil recruitment to the liver. Production of cytokines, chemokines, and danger signals results in activation of resident hepatocytes, leukocytes, and Kupffer cells. The role of neutrophils as the main amplifiers of liver injury in IRI has been recognized in many publications...
September 18, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28910354/differential-impact-of-the-dual-ccr2-ccr5-inhibitor-cenicriviroc-on-migration-of-monocyte-and-lymphocyte-subsets-in-acute-liver-injury
#4
Tobias Puengel, Oliver Krenkel, Marlene Kohlhepp, Eric Lefebvre, Tom Luedde, Christian Trautwein, Frank Tacke
A hallmark of acute hepatic injury is the recruitment of neutrophils, monocytes and lymphocytes, including natural killer (NK) or T cells, towards areas of inflammation. The recruitment of leukocytes from their reservoirs bone marrow or spleen into the liver is directed by chemokines such as CCL2 (for monocytes) and CCL5 (for lymphocytes). We herein elucidated the impact of chemokine receptor inhibition by the dual CCR2 and CCR5 inhibitor cenicriviroc (CVC) on the composition of myeloid and lymphoid immune cell populations in acute liver injury...
2017: PloS One
https://www.readbyqxmd.com/read/28905319/pi3k-inhibition-protects-mice-from-nafld-by-down-regulating-cmklr1-and-nlrp3-in-kupffer-cells
#5
Wenfeng Zhang, Yan Liu, Mingbing Wu, Xiwen Zhu, Tao Wang, Kun He, Peizhi Li, Xiaoling Wu
Inflammation induced by high-fat diet (HFD) is of critical importance in the development of hepatic steatosis. The role of chemerin in the progress of nonalcoholic fatty liver disease (NAFLD) remains controversial. Here, we have evaluated the effects and mechanism of chemerin on insulin sensitivity and inflammation. An inhibitor (wortmannin) and agonist (insulin-like growth factor 1 (IGF-1) of phosphatidyl inositol 3-kinase (PI3K) were applied to Kupffer cells (KCs) after treatment with a concentration gradient of chemerin in vitro...
September 13, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28898507/growth-differentiation-factor-15-predicts-advanced-fibrosis-in-biopsy-proven-non-alcoholic-fatty-liver-disease
#6
Bo Kyung Koo, Sung Hee Um, Dong Soo Seo, Sae Kyung Joo, Jeong Mo Bae, Jeong Hwan Park, Mee Soo Chang, Jung Ho Kim, Jieun Lee, Won-Il Jeong, Won Kim
BACKGROUND & AIMS: We explored whether growth differentiation factor 15 (GDF15) affects the histological severity of non-alcoholic fatty liver disease (NAFLD) independent of insulin resistance. METHODS: In a biopsy-proven NAFLD cohort, we measured serum GDF15 levels using enzyme-linked immunosorbent assays. RESULTS: Among 190 subjects (mean age, 53±14 years; men, 52.1%), 72 (men, 65.3%) and 78 (men, 44.9%) were diagnosed with biopsy-proven non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH), respectively...
September 12, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28882574/kupffer-cells-activation-promoted-binge-drinking-induced-fatty-liver-by-activating-lipolysis-in-white-adipose-tissues
#7
Yu-Ying Zhao, Rui Yang, Mo Xiao, Min-Jie Guan, Ning Zhao, Tao Zeng
Kupffer cells (KCs) have been suggested to play critical roles in chronic ethanol induced early liver injury, but the role of KCs in binge drinking-induced hepatic steatosis remains unclear. This study was designed to investigate the roles of KCs inhibitor (GdCl3) and TNF-α antagonist (etanercept) on binge drinking-induced liver steatosis and to explore the underlying mechanisms. C57BL/6 mice were exposed to three doses of ethanol (6g/kg body weight) to mimic binge drinking-induced fatty liver. The results showed that both GdCl3 and etanercept partially but significantly alleviated binge drinking-induced increase of hepatic triglyceride (TG) level, and reduced fat droplets accumulation in mice liver...
September 4, 2017: Toxicology
https://www.readbyqxmd.com/read/28875937/notch-her12-signalling-modulates-motile-immotile-cilia-ratio-downstream-of-foxj1a-in-zebrafish-left-right-organizer
#8
Barbara Tavares, Raquel Jacinto, Pedro Sampaio, Sara Pestana, Andreia Pinto, Andreia Vaz, Mónica Roxo-Rosa, Rui Gardner, Telma Lopes, Britta Schilling, Ian Henry, Leonor Saúde, Susana Santos Lopes
Foxj1a is necessary and sufficient to specify motile cilia. Using transcriptional studies and slow-scan two-photon live imaging capable of identifying the number of motile and immotile cilia, we now established that the final number of motile cilia depends on Notch signalling (NS). We found that despite all left-right organizer (LRO) cells express foxj1a and the ciliary axonemes of these cells have dynein arms some cilia remain immotile. We identified that this decision is taken early in development in the Kupffer's Vesicle (KV) precursors the readout being her12 transcription...
September 5, 2017: ELife
https://www.readbyqxmd.com/read/28874772/antibody-dependent-fragmentation-is-a-newly-identified-mechanism-of-cell-killing-in-vivo
#9
Pei Xiong Liew, Jung Hwan Kim, Woo-Yong Lee, Paul Kubes
The prevailing view is that therapeutic antibodies deplete cells through opsonization and subsequent phagocytosis, complement-dependent lysis or antibody-dependent cellular-cytotoxicity. We used high resolution in vivo imaging to identify a new antibody-dependent cell death pathway where Kupffer cells ripped large fragments off crawling antibody-coated iNKT cells. This antibody-dependent fragmentation process resulted in lethality and depletion of crawling iNKT cells in the liver sinusoids and lung capillaries...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871174/erythropoietin-enhances-kupffer-cell-number-and-activity-in-the-challenged-liver
#10
Dafna Gilboa, Yasmin Haim-Ohana, Naamit Deshet-Unger, Nathalie Ben-Califa, Sahar Hiram-Bab, Debby Reuveni, Ehud Zigmond, Max Gassmann, Yankel Gabet, Chen Varol, Drorit Neumann
Erythropoietin (EPO) is the main hormone driving mammalian erythropoiesis, with activity mediated via the surface receptor, EPO-R, on erythroid progenitor cells. Recombinant human EPO is currently used clinically for the treatment of anemia in patients with end-stage renal disease, and in certain cancer patients suffering from anemia induced either by the tumor itself or by chemotherapy. EPO-R expression is also detected in non-erythroid cells, including macrophages present in the peritoneum, spleen, and bone marrow (BM)...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870676/hypothermic-oxygenated-perfusion-hope-for-fatty-liver-grafts-in-rats-and-humans
#11
P Kron, A Schlegel, L Mancina, P-A Clavien, P Dutkowski
BACKGROUND: Pretreatment of marginal organs by perfusion is a promising opportunity to consider more organs for transplantation. Protection of human DCD (donation after cardiac death) livers by a novel machine perfusion technique, hypothermic oxygenated perfusion (HOPE), was recently established. Here we tested in a rodent transplant model, whether HOPE is also useful for fatty liver grafts. METHODS: Rats were fed over 3 weeks with a special Methionine-Choline-Deficient-Diet (MCDD) to induce severe hepatic macrosteatosis (≥60%)...
September 1, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28864467/upregulation-of-epac-1-in-hepatic-stellate-cells-by-prostaglandin-e2-in-liver-fibrosis-is-associated-with-reduced-fibrogenesis
#12
Marlies Schippers, Leonie Beljaars, Eduard Post, Sophie Lotersztajn, Catharina Reker-Smit, Bing Han, Pablo A Llancao, Martina Schmidt, Klaas Poelstra
Exchange protein activated by cAMP (Epac-1) is an important signaling mechanism for cAMP-mediated effects but factors that change Epac-1 levels are unknown. Such factors are relevant because it has been postulated that Epac-1 directly affects fibrogenesis. Prostaglandin E2 (PGE2) is a well-known cAMP-activator and we therefore studied the effects of this cyclo-oxygenase product on Epac-1 expression and on fibrogenesis within the liver. Liver fibrosis was induced by 8 weeks CCL4 administration to mice. In the last 2 weeks, mice received vehicle, PGE2, COX-2 inhibitor Niflumic acid (NFA), or PGE2 coupled to cell-specific carriers to hepatocytes, Kupffer cells or hepatic stellate cells (HSC)...
September 1, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28863932/tissue-iron-quantification-in-chronic-liver-diseases-using-mri-shows-a-relationship-between-iron-accumulation-in-liver-spleen-and-bone-marrow
#13
M França, L Martí-Bonmatí, G Porto, S Silva, S Guimarães, Á Alberich-Bayarri, J R Vizcaíno, H Pessegueiro Miranda
AIM: To investigate iron loading within the liver, pancreas, spleen, and bone marrow using magnetic resonance imaging (MRI) transverse relaxation rate (R2*), in patients with diffuse liver diseases; to evaluate the relationships between iron accumulation in these tissue compartments; and to assess the association between tissue iron overload and the pattern of hepatic cellular iron distribution (hepatocytes versus Kupffer cells). MATERIAL AND METHODS: Fifty-six patients with diffuse liver diseases had MRI-derived R2* values, using a multi-echo chemical-shift encoded MRI sequence, of the liver, pancreas, spleen, and vertebral bone marrow...
August 29, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28861173/therapeutic-effect-of-rosuvastatin-and-propylthiouracil-on-ameliorating-high-cholesterol-diet-induced-fatty-liver-disease-fibrosis-and-inflammation-in-rabbit
#14
Pao-Yuan Lin, Chih-Hung Chen, Christopher Glenn Wallace, Kuan-Hung Chen, Chia-Lo Chang, Hong-Hwa Chen, Pei-Hsun Sung, Kun-Chen Lin, Sheung-Fat Ko, Cheuk-Kwan Sun, Hsueh-Wen Chang, Pei-Lin Shao, Mel S Lee, Hon-Kan Yip
This study tested the hypothesis that high-cholesterol diet (HCD)-induced fatty liver disease could be ameliorated by rosuvastatin (Ros) and propylthiouracil (PTU) therapy. Thirty-two Zealand rabbits were equally divided into group 1 (sham-control), group 2 (HCD for 8 weeks), group 3 [HCD-Ros (20 mg/kg/day administration after 4-week HFD for 4 weeks)], group 4 [HCD-PTU (0.1% PTU in drinking water) with treatment course as group 3]. Liver weight, fibrosis, collagen deposition area, and serum levels of AST/ALT were highest in group 2, lowest in group 1, and significantly higher in group 4 than group 3 (all P<0...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28860765/silica-nanoparticles-induce-liver-fibrosis-via-tgf-%C3%AE-1-smad3-pathway-in-icr-mice
#15
Yang Yu, Junchao Duan, Yang Li, Yanbo Li, Li Jing, Man Yang, Ji Wang, Zhiwei Sun
The liver is one of the target organs of silica nanoparticles (SiO2 NPs) but the toxic mechanism on the liver still remains unclear. This study aimed to explore the hepatic toxicity and its mechanism through repeated intravenous exposure to SiO2 NPs in ICR mice. Results indicated that SiO2 NPs could be distributed in hepatocytes, Kupffer cells, and hepatic stellate cells, and induce hepatic dysfunction as well as granuloma formation in the liver. The increase of lipid peroxide level and decrease of antioxidant enzyme activities in the liver indicated that SiO2 NPs could induce hepatic oxidative damage...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28852648/hepatic-immune-microenvironment-in-alcoholic-and-nonalcoholic-liver-disease
#16
REVIEW
Jin-Seok Byun, Hyon-Seung Yi
Many types of innate (natural killer cells, natural killer T cells, and Kupffer cells/macrophages) and adaptive (T cells and B cells) immune cells are enriched within the liver and function in liver physiology and pathology. Liver pathology is generally induced by two types of immunologic insults: failure to eliminate antigens derived from the gastrointestinal tract which are important for host defense and an impaired tissue protective tolerance mechanism that helps reduce the negative outcomes of immunopathology...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28851562/viral-load-affects-the-immune-response-to-hbv-in-mice-with-humanized-immune-system-and-liver
#17
Mathilde Dusséaux, Guillemette Masse-Ranson, Sylvie Darche, James Ahodantin, Yan Li, Oriane Fiquet, Elodie Beaumont, Pierrick Moreau, Lise Rivière, Christine Neuveut, Patrick Soussan, Philippe Roingeard, Dina Kremsdorf, James P Di Santo, Helene Strick-Marchand
BACKGROUND & AIMS: Hepatitis B virus (HBV) infects hepatocytes, but the mechanisms of the immune response against the virus, and how it affects disease progression, are unclear. METHODS: We performed studies with BALB/c Rag2(-/-)Il2rg(-/-)Sirpa(NOD)Alb-uPA(tg/tg) mice, stably engrafted with human hepatocytes (HUHEP) with or without a human immune system (HIS). HUHEP and HIS-HUHEP mice were given an intraperitoneal injection of HBV. Mononuclear cells were isolated from spleen and liver for analysis by flow cytometry...
August 26, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28844960/bile-acid-receptors-in-the-biliary-tree-tgr5-in-physiology-and-disease
#18
REVIEW
Kathleen Deutschmann, Maria Reich, Caroline Klindt, Carola Dröge, Lina Spomer, Dieter Häussinger, Verena Keitel
Bile salts represent signalling molecules with a variety of endocrine functions. Bile salt effects are mediated by different receptor molecules, comprising ligand-activated nuclear transcription factors as well as G protein-coupled membrane-bound receptors. The farnesoid X receptor (FXR) and the plasma membrane-bound G protein-coupled receptor TGR5 (Gpbar-1) are prototypic bile salt receptors of both classes and are highly expressed in the liver including the biliary tree as well as in the intestine. In liver, TGR5 is localized in different non-parenchymal cells such as sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells and small and large cholangiocytes...
August 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28840534/gut-liver-axis-gut-microbiota-in-shaping-hepatic-innate-immunity
#19
REVIEW
Xunyao Wu, Zhigang Tian
Gut microbiota play an essential role in shaping immune cell responses. The liver was continuously exposed to metabolic products of intestinal commensal bacterial through portal vein and alteration of gut commensal bateria was always associated with increased risk of liver inflammation and autoimmune disease. Considered as a unique immunological organ, the liver is enriched with a large number of innate immune cells. Herein, we summarize the available literature of gut microbiota in shaping the response of hepatic innate immune cells including NKT cells, NK cells, γδ T cells and Kupffer cells during health and disease...
August 22, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28829572/immunomodulatory-therapy-of-inflammatory-liver-disease-using-selectin-binding-glycopolymers
#20
Matthias Bartneck, Christopher Thorsten Schlößer, Matthias Barz, Rudolf Zentel, Christian Trautwein, Twan Lammers, Frank Tacke
Immunotherapies have the potential to significantly advance treatment of inflammatory disease and cancer, which are in large parts driven by immune cells. Selectins control the first step in immune cell adhesion and extravasation, thereby guiding leukocyte trafficking to tissue lesions. We analyzed four different highly specific selectin-binding glycopolymers, based on linear poly(2-hydroxypropyl)-methacrylamide (PHPMA) polymers. These glycopolymers contain either the tetrasaccharide sialyl-Lewis(X) (SLe(X)), or the individual carbohydrates fucose, galactose, and sialic acids mimicking the complex SLe(X) binding motive...
August 22, 2017: ACS Nano
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