Sonja Suvakov, Ranine Ghamrawi, Hajrunisa Cubro, Haitao Tu, Wendy M White, Yvonne S Butler Tobah, Natasa M Milic, Joseph P Grande, Julie M Cunningham, Fouad T Chebib, Larissa G P Langhi Prata, Yi Zhu, Tamara Tchkonia, James L Kirkland, Karl A Nath, Aleksandar Milosavljevic, Vesna D Garovic
BACKGROUND: Preeclampsia is a pregnancy-specific hypertensive disorder characterized by proteinuria and/or multisystem involvement. Disease-specific therapy has yet to be developed due to the lack of understanding of underlying mechanism(s). We postulate that accelerated ageing in general, and particularly cellular senescence, play a role in its pathophysiology. METHODS: We compared women with preeclampsia vs. normotensive pregnancies with respect to epigenetic markers of ageing and markers of senescence in tissues/organs affected by preeclampsia (blood, urine, adipose tissue, and kidney)...
August 11, 2021: EBioMedicine