Omayra C D Liesdek, Rolf T Urbanus, Steven de Maat, Linda M de Heer, Faiz Z Ramjankhan, Silvie A E Sebastian, Albert Huisman, Nicolaas de Jonge, Aryan Vink, Kathelijn Fischer, Coen Maas, Willem J L Suyker, Roger E G Schutgens
Thrombus formation is a common complication during left ventricular assist device (LVAD) therapy, despite anticoagulation with vitamin K antagonists (VKA) and a platelet inhibitor. Plasma levels of markers for primary and secondary hemostasis and contact activation were determined before LVAD implantation and 6 and 12 months thereafter in 37 adults with end-stage heart failure. Twelve patients received a HeartMate 3, 7 patients received a HeartWare, and 18 patients received a HeartMate II. At baseline, patients had elevated plasma levels of the platelet protein upon activation, β-thromboglobulin, and active von Willebrand factor in thrombogenic state (VWFa), which remained high after LVAD implantation...
November 22, 2022: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs