keyword
https://read.qxmd.com/read/38502100/impact-of-the-reduction-time-dependent-electrical-conductivity-of-graphene-nanoplatelet-coated-aligned-bombyx-mori-silk-scaffolds-on-electrically-stimulated-axonal-growth
#21
JOURNAL ARTICLE
Jitu Mani Das, Jnanendra Upadhyay, Michael G Monaghan, Rajiv Borah
Graphene-based nanomaterials, renowned for their outstanding electrical conductivity, have been extensively studied as electroconductive biomaterials (ECBs) for electrically stimulated tissue regeneration. However, using eco-friendly reducing agents like l-ascorbic acid (l-Aa) can result in lower conductive properties in these ECBs, limiting their full potential for smooth charge transfer in living tissues. Moreover, creating a flexible biomaterial scaffold using these materials that accurately mimics a specific tissue microarchitecture, such as nerves, poses additional challenges...
March 19, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38500751/advanced-hemodynamics-for-prognostication-in-heart-failure-the-pursuit-of-the-patient-specific-tipping-point
#22
JOURNAL ARTICLE
Jonathan Grinstein
BACKGROUND: Objective tools to define the optimal time for referral for advanced therapies and to help guide escalation and de-escalation of support can improve management decisions and outcomes for patients with advanced heart failure. The current parameters have variable prognostic potential depending on the patient population being studied and often have arbitrary thresholds. METHODS: Here, a mathematical and physiological framework to define the patient-specific tipping point of myocardial energetics is defined...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38498600/angiotensin-1-7-treatment-early-in-life-prevents-cardiac-hypertrophy-in-adult-hypertensive-rats
#23
JOURNAL ARTICLE
Carolina Nobre Ribeiro Pontes, Amanda de Sá Martins de Bessa, Larissa Matuda Macedo, Marcos Divino Ferreira-Junior, Keilah Valéria Naves Cavalcante, Hericles Mesquita Campos, Vanessa Rafaela Milhomem Cruz-Leite, Ângela Ribeiro Neves, Rodrigo Mello Gomes, Paulo César Ghedini, Manoel Francisco Biancardi, Elizabeth Pereira Mendes, Clayton Luiz Borges, Gustavo Rodrigues Pedrino, Carlos Henrique Castro
Angiotensin (Ang)-(1-7) is a cardioprotective peptide of the renin-angiotensin system. Pre-puberty has been considered as a later susceptible window of development and stressful factors in this life phase can induce chronic diseases in adulthood. We aimed to investigate whether the treatment with Ang-(1-7) during the pre-puberty could attenuate the development of hypertension and cardiac injury in adult spontaneously hypertensive rats (SHR). SHR were treated with Ang-(1-7) (24 μg/Kg/h) from 4 to 7 weeks of age...
March 12, 2024: Journal of Cardiovascular Pharmacology
https://read.qxmd.com/read/38496860/heart-failure-with-sarcopenia-a-bibliometric-review-from-1995-to-2022
#24
REVIEW
Yaping You, Tiantian Meng, Xinyu Lu, Xueping Zhu, Meng Lv, Xintian Shou, Qingyong He, Yuanhui Hu
This study aimed to dynamically track the priorities and potential research hotspots in the field of heart failure with sarcopenia. Using CiteSpace, we analyzed the literature on heart failure with sarcopenia from the Web of Science database from 1995 to 2022. The analysis encompassed 507 records, revealing an overall upward trend in annual publication volume. Europe and the United States emerged as the primary regions for publishing, particularly driven by contributions from developed countries such as the United States, Germany, and Italy...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38494729/an-autopsy-case-of-fulminant-myocarditis-with-massive-left-ventricular-calcification
#25
JOURNAL ARTICLE
Satsuki Yagi-Nakajima, Masanobu Miura, Shun Sawada, Takahiro Funaki, Kumi Uchimura, Kai Susukita, Tsubasa Hatakeyama, Yuta Kagaya, Hiroki Saito, Kenjiro Sato, Masanori Kanazawa, Masateru Kondo, Hideaki Endo, Hiroshi Yaegashi, Akihiro Nakamura
Myocardial calcification in myocarditis is rare and may be linked to poor outcomes. We herein report a case of fulminant myocarditis with massive myocardial calcification and its pathological outcomes at autopsy. A 49-year-old man experienced chest pain and was diagnosed with acute myocarditis. His cardiac function did not recover despite mechanical circulatory support in combination with V-A extracorporeal membrane oxygenation and IMPELLA CP® . He eventually developed sepsis and gastrointestinal bleeding and died on day 27...
2024: Internal Medicine
https://read.qxmd.com/read/38492622/targeting-inflammatory-signaling-pathways-with-sglt2-inhibitors-insights-into-cardiovascular-health-and-cardiac-cell-improvement
#26
REVIEW
Fatmah R Alsereidi, Zenith Khashim, Hezlin Marzook, Anamika Gupta, Ahmed M Shaaban, Mahmoud M Ramadan, Mohamed A Saleh
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have attracted significant attention for their broader therapeutic impact beyond simply controlling blood sugar levels, particularly in their ability to influence inflammatory pathways. This review delves into the anti-inflammatory properties of SGLT2 inhibitors, with a specific focus on canagliflozin, empagliflozin, and dapagliflozin. One of the key mechanisms through which SGLT2 inhibitors exert their anti-inflammatory effects is by activating AMP-activated protein kinase (AMPK), a crucial regulator of both cellular energy balance and inflammation...
March 14, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38491822/the-carbon-monoxide-prodrug-ocom-21-increases-ca-2-sensitivity-of-the-cardiac-myofilament
#27
JOURNAL ARTICLE
Fergus M Payne, Samantha Nie, Gary M Diffee, Gerard T Wilkins, David S Larsen, Joanne C Harrison, James C Baldi, Ivan A Sammut
Patients undergoing cardiopulmonary bypass procedures require inotropic support to improve hemodynamic function and cardiac output. Current inotropes such as dobutamine, can promote arrhythmias, prompting a demand for improved inotropes with little effect on intracellular Ca2+ flux. Low-dose carbon monoxide (CO) induces inotropic effects in perfused hearts. Using the CO-releasing pro-drug, oCOm-21, we investigated if this inotropic effect results from an increase in myofilament Ca2+ sensitivity. Male Sprague Dawley rat left ventricular cardiomyocytes were permeabilized, and myofilament force was measured as a function of -log [Ca2+ ] (pCa) in the range of 9...
March 2024: Physiological Reports
https://read.qxmd.com/read/38491813/cardiovascular-anti-inflammatory-drugs-repurposed-for-treating-or-preventing-cancer-a-systematic-review-and-meta-analysis-of-randomized-trials
#28
JOURNAL ARTICLE
David J Benjamin, Alyson Haslam, Vinay Prasad
BACKGROUND: Due to encouraging pre-clinical data and supportive observational studies, there has been growing interest in applying cardiovascular drugs (including aspirin, angiotensin-converting enzyme [ACE] inhibitors, statins, and metformin) approved to treat diseases such as hypertension, hyperlipidemia, and diabetes mellitus to the field of oncology. Moreover, given growing costs with cancer care, these medications have offered a potentially more affordable avenue to treat or prevent recurrence of cancer...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491741/obesity-the-perfect-storm-for-heart-failure
#29
REVIEW
Maria Lembo, Teresa Strisciuglio, Celeste Fonderico, Costantino Mancusi, Raffaele Izzo, Valentina Trimarco, Alessandro Bellis, Emanuele Barbato, Giovanni Esposito, Carmine Morisco, Speranza Rubattu
Obesity condition causes morphological and functional alterations involving the cardiovascular system. These can represent the substrates for different cardiovascular diseases, such as atrial fibrillation, coronary artery disease, sudden cardiac death, and heart failure (HF) with both preserved ejection fraction (EF) and reduced EF. Different pathogenetic mechanisms may help to explain the association between obesity and HF including left ventricular remodelling and epicardial fat accumulation, endothelial dysfunction, and coronary microvascular dysfunction...
March 15, 2024: ESC Heart Failure
https://read.qxmd.com/read/38490900/diagnosis-and-management-of-vasoplegia-in-temporary-mechanical-circulatory-support-a-narrative-review
#30
REVIEW
Jamel Ortoleva, Adam A Dalia, Dominic V Pisano, Alexander Shapeton
Refractory vasodilatory shock, or vasoplegia, is a pathophysiologic state observed in the intensive care unit and operating room in patients with a variety of primary diagnoses. Definitions of vasoplegia vary by source but are qualitatively defined clinically as a normal or high cardiac index and low systemic vascular resistance causing hypotension despite high-dose vasopressors in the setting of euvolemia. This definition can be difficult to apply to patients undergoing mechanical circulatory support (MCS)...
February 23, 2024: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38489988/blood-flow-and-emboli-transport-patterns-during-venoarterial-extracorporeal-membrane-oxygenation-a-computational-fluid-dynamics-study
#31
JOURNAL ARTICLE
Mehrdad Khamooshi, Avishka Wickramarachchi, Tim Byrne, Michael Seman, David F Fletcher, Aidan Burrell, Shaun D Gregory
PROBLEM: Despite advances in Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO), a significant mortality rate persists due to complications. The non-physiological blood flow dynamics of VA-ECMO may lead to neurological complications and organ ischemia. Continuous retrograde high-flow oxygenated blood enters through a return cannula placed in the femoral artery which opposes the pulsatile deoxygenated blood ejected by the left ventricle (LV), which impacts upper body oxygenation and subsequent hyperoxemia...
March 11, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38488139/a-review-of-high-intensity-interval-training-in-heart-transplant-recipients-current-knowledge-and-future-perspectives
#32
JOURNAL ARTICLE
Kari Nytrøen, Katrine Rolid
OBJECTIVE: This review reports how exercise-based rehabilitation strategies have developed over the past decades, and it specifically focuses on the effectiveness, safety, and implementation of high-intensity interval training (HIIT). It provides an overview of the historical progression, main research findings, and considerations surrounding HIIT as the preferred exercise modality for recipients of heart transplant (HTx). REVIEW METHODS: The review includes a timeline of studies spanning from 1976-2023...
March 15, 2024: Journal of Cardiopulmonary Rehabilitation and Prevention
https://read.qxmd.com/read/38484803/gender-disparities-and-predictors-of-in-hospital-mortality-with-takotsubo-cardiomyopathy-insights-from-national-inpatient-sample
#33
JOURNAL ARTICLE
Muhammad Usman Almani, Rasha Khan, Muhammad Qudrat-Ullah, Muhammad Yousuf, Yaqi Zhang, Naveen Baskaran, Mohammad Hamza, Raphael Bonita
BACKGROUND: Takotsubo cardiomyopathy (TCM) is classically associated with significant gender disparities, such that it is more prevalent in females, but the clinical outcomes are worse for male patients. The goal of this study was to assess contemporary gender disparities in clinical outcomes of TCM hospitalizations and to determine predictors of male in-hospital mortality. METHODS: This was a retrospective analysis involving adult hospitalizations for TCM in the U...
March 12, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38484438/yoga-nidra-for-hypertension-a-systematic-review-and-meta-analysis
#34
REVIEW
Navdeep Ahuja, Praag Bhardwaj, Monika Pathania, Dilasha Sethi, Arjun Kumar, Ashwin Parchani, Akshita Chandel, Aashish Phadke
BACKGROUND: Hypertension is a prevalent chronic condition that affects a substantial proportion of the world's population. Medications are commonly prescribed for hypertension management, but non-pharmacological interventions like yoga are gaining popularity. OBJECTIVE: The purpose of this systematic review and meta-analysis is to assess the efficacy of Yoga Nidra (YN) for the management of hypertension. METHODS: A systematic review and meta-analysis of clinical trials, i...
March 13, 2024: Journal of Ayurveda and Integrative Medicine
https://read.qxmd.com/read/38481636/a-patient-with-extensive-st-elevation-myocardial-infarction-who-underwent-emergent-impella-cp%C3%A2-assisted-off-pump-coronary-artery-bypass-without-mechanical-complication
#35
Yojiro Machii, Akira Sezai, Yuki Hayashi, Atsushi Harada, Keita Kamata, Naoki Eguchi, Masashi Tanaka
UNLABELLED: Impella (Abiomed Inc., Danvers, MA, USA) assisted off-pump coronary artery bypass has been increasingly reported in recent years. However, there have been no reports of the procedures performed for acute myocardial infarction in which the patient is hemodynamically unstable. We report a case of a 73-year-old man with cardiogenic shock due to extensive ST elevation acute myocardial infarction that worsened despite Impella CP® support. Because of the fragile myocardium in the acute phase of myocardial infarction, Impella assisted off-pump coronary artery bypass graft causes a high risk of myocardial injury, but we were able to safely perform the procedure by ingenious techniques...
March 2024: Journal of Cardiology Cases
https://read.qxmd.com/read/38481545/antispasmodic-cardioprotective-and-blood-pressure-lowering-properties-of-gomphrena-perennis-l-and-its-mechanisms-of-action
#36
JOURNAL ARTICLE
Adriana Milena Bonilla Bonilla, Tatiana C Gavilánez Buñay, Matías Bayley, Germán A Colareda, Soledad I Matera, María Luján Flores, Osvaldo León Córdoba, Julián J Prieto, María Esperanza Ruiz, Alicia E Consolini, María Inés Ragone
BACKGROUND: Gomphrena perennis L. is a native plant of South America whose pharmacological properties have not been studied yet. AIM: To evaluate the cardiovascular and intestinal pharmacological effects of Gomphrena perennis L. leaves tincture (GphT) and the mechanisms involved. EXPERIMENTAL PROCEDURE: The chromatographic profile of GphT was done. Its ex vivo effects were evaluated by contractile concentration-response curves (CRCs) obtained from the agonist carbachol or calcium found in isolated rat small intestine, as well as in the relaxant CRCs...
March 2024: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/38479593/evaluation-of-the-translation-of-multiple-cardiovascular-regulatory-mechanisms-in-the-anesthetized-dog
#37
JOURNAL ARTICLE
Olivera Antic, Yevgeniya E Koshman, Brandan M Bird, Geena Jasiek, Amanda S Wilsey, Scott W Mittelstadt, C Michael Foley
The strategic and targeted use of an anesthetized canine cardiovascular model early in drug discovery enables a comprehensive cardiovascular and electrophysiological assessment of potential safety liabilities and guides compound selection prior to initiation of chronic toxicological studies. An ideal model would enable exposure-response relationships to guide safety margin calculations, have a low threshold to initiate, and have quick delivery of decision quality data. We have aimed to profile compounds with diverse mechanism of actions (MoAs) of "non-QT" cardiovascular drug effects and evaluate the ability of nonclinical in vivo cardiovascular models to detect clinically reported effects...
March 11, 2024: Journal of Pharmacological and Toxicological Methods
https://read.qxmd.com/read/38476289/pathogenic-truncating-filamin-c-mutations-presenting-as-acute-myocarditis-a-case-series-with-insights-from-cardiac-magnetic-resonance-and-histological-analysis
#38
Apostolos Vrettos, Polyvios Demetriades, Martín Ortiz, Fernando Domínguez, Pablo García-Pavía, M Paz Suárez-Mier, Thomas Gossios, Konstantinos Savvatis
BACKGROUND: The exact mechanisms underlying the pathogenesis of myocarditis are not always understood, but there is emerging evidence to suggest that genetic factors may play a significant role. CASE SUMMARY: Herein, we present six cases in which clinical, biochemical, and cardiovascular magnetic resonance data were consistent with myocarditis, and genetic testing subsequently revealed pathogenic filamin C (FLNC) mutations. Three patients presented with ventricular arrhythmias, two with severe biventricular dysfunction, and two suffered sudden cardiac arrest...
March 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38475866/epigenetic-age-acceleration-and-risk-of-aortic-valve-stenosis-a-bidirectional-mendelian-randomization-study
#39
JOURNAL ARTICLE
Wanqian Pan, Qi Huang, Le Zhou, Jia Lin, Xiaojiao Du, Xiaodong Qian, Tingbo Jiang, Weixiang Chen
BACKGROUND: Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to aging. DNA methylation-based epigenetic clock is now recognized as highly accurate predictor of the aging process and associated health outcomes. This study aimed to explore the causal relationship between epigenetic clock and AVS by conducting a bidirectional Mendelian randomization (MR) analysis. METHODS: Summary genome-wide association study statistics of epigenetic clocks (HannumAge, HorvathAge, PhenoAge, and GrimAge) and AVS were obtained and assessed for significant instrumental variables from Edinburgh DataShare (n = 34,710) and FinnGen biobank (cases = 9870 and controls = 402,311)...
March 12, 2024: Clinical Epigenetics
https://read.qxmd.com/read/38474123/early-impairment-of-paracrine-and-phenotypic-features-in-resident-cardiac-mesenchymal-stromal-cells-after-thoracic-radiotherapy
#40
JOURNAL ARTICLE
Vittorio Picchio, Roberto Gaetani, Francesca Pagano, Yuriy Derevyanchuk, Olivia Pagliarosi, Erica Floris, Claudia Cozzolino, Giacomo Bernava, Antonella Bordin, Filipe Rocha, Ana Rita Simões Pereira, Augusto Ministro, Ana Teresa Pinto, Elena De Falco, Gianpaolo Serino, Diana Massai, Radia Tamarat, Maurizio Pesce, Susana Constantino Rosa Santos, Elisa Messina, Isotta Chimenti
Radiotherapy-induced cardiac toxicity and consequent diseases still represent potential severe late complications for many cancer survivors who undergo therapeutic thoracic irradiation. We aimed to assess the phenotypic and paracrine features of resident cardiac mesenchymal stromal cells (CMSCs) at early follow-up after the end of thoracic irradiation of the heart as an early sign and/or mechanism of cardiac toxicity anticipating late organ dysfunction. Resident CMSCs were isolated from a rat model of fractionated thoracic irradiation with accurate and clinically relevant heart dosimetry that developed delayed dose-dependent cardiac dysfunction after 1 year...
March 1, 2024: International Journal of Molecular Sciences
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