Vittorio Picchio, Roberto Gaetani, Francesca Pagano, Yuriy Derevyanchuk, Olivia Pagliarosi, Erica Floris, Claudia Cozzolino, Giacomo Bernava, Antonella Bordin, Filipe Rocha, Ana Rita Simões Pereira, Augusto Ministro, Ana Teresa Pinto, Elena De Falco, Gianpaolo Serino, Diana Massai, Radia Tamarat, Maurizio Pesce, Susana Constantino Rosa Santos, Elisa Messina, Isotta Chimenti
Radiotherapy-induced cardiac toxicity and consequent diseases still represent potential severe late complications for many cancer survivors who undergo therapeutic thoracic irradiation. We aimed to assess the phenotypic and paracrine features of resident cardiac mesenchymal stromal cells (CMSCs) at early follow-up after the end of thoracic irradiation of the heart as an early sign and/or mechanism of cardiac toxicity anticipating late organ dysfunction. Resident CMSCs were isolated from a rat model of fractionated thoracic irradiation with accurate and clinically relevant heart dosimetry that developed delayed dose-dependent cardiac dysfunction after 1 year...
March 1, 2024: International Journal of Molecular Sciences