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Infra-Red Spectroscopy

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https://www.readbyqxmd.com/read/28330736/hyperspectral-imaging-using-near-infrared-spectroscopy-to-monitor-coat-thickness-uniformity-in-the-manufacture-of-a-transdermal-drug-delivery-system
#1
Naresh Pavurala, Xiaoming Xu, Yellela S R Krishnaiah
Hyperspectral imaging using near infrared spectroscopy (NIRS) integrates spectroscopy and conventional imaging to obtain both spectral and spatial information of materials. The non-invasive and rapid nature of hyperspectral imaging using NIRS makes it a valuable process analytical technology (PAT) tool for in-process monitoring and control of the manufacturing process for transdermal drug delivery systems (TDS). The focus of this investigation was to develop and validate the use of Near Infra-red (NIR) hyperspectral imaging to monitor coat thickness uniformity, a critical quality attribute (CQA) for TDS...
March 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28330204/endophytic-fungal-isolate-mediated-biosynthesis-of-silver-nanoparticles-and-their-free-radical-scavenging-activity-and-anti-microbial-studies
#2
Vasudeva Reddy Netala, Venkata Subbaiah Kotakadi, Pushpalatha Bobbu, Susmila Aparna Gaddam, Vijaya Tartte
The present study reports that the biosynthesis of AgNPs using an endophytic fungus isolated from the ethnomedicinal plant Centella asiatica. The endophytic fungus was identified as Aspergillus versicolor ENT7 based on 18S rRNA gene sequencing (NCBI Accession number KF493864). The AgNPs synthesized were characterized by UV-visible spectroscopy, Fourier transform infra-red spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), particle size analyzer, and zeta potential measurements...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28325312/structural-and-enzyme-kinetic-studies-of-retrograded-starch-inhibition-of-%C3%AE-amylase-and-consequences-for-intestinal-digestion-of-starch
#3
Hamung Patel, Paul G Royall, Simon Gaisford, Gareth R Williams, Cathrina H Edwards, Frederick J Warren, Bernadine M Flanagan, Peter R Ellis, Peter J Butterworth
Retrograded starch is known to be resistant to digestion. We used enzyme kinetic experiments to examine how retrogradation of starch affects amylolysis catalysed by porcine pancreatic amylase. Parallel studies employing differential scanning calorimetry, infra red spectroscopy, X-ray diffraction and NMR spectroscopy were performed to monitor changes in supramolecular structure of gelatinised starch as it becomes retrograded. The total digestible starch and the catalytic efficiency of amylase were both decreased with increasing evidence of retrogradation...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28324991/features-of-cerebral-oxygenation-detects-brain-injury-in-premature-infants
#4
John M O'Toole, Mmoloki Kenosi, Daragh Finn, Geraldine B Boylan, Eugene M Dempsey
Babies born prematurely can develop brain injury within days after birth. Early identification of high-risk infants enables appropriate clinical care to mitigate potential lifelong disabilities. Near infra-red spectroscopy is an established technology that can provide continuous measurements of cerebral oxygen saturation (rcSO2) over this critical period. We develop a feature set of the rcSO2 signal for the purpose of detecting brain injury. Our feature set contains amplitude, spectral, and fractal dimension features within 5 frequency bands...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322162/arginine-complexes-with-simvastatin-apparent-solubility-in-vitro-dissolution-and-solid-state-characterization
#5
Mmr Meor Mohd Affandi, Minaketan Tripathy, Aba Majeed
Categorized as a Biopharmaceutics Classification System (BCS) Class II drugs, statin exhibit low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. This paper describes a de novo approach to enhance the aqueous solubility of one of the most commonly prescribed statins i.e. simvastatin (SMV) by forming a complex (SMV-ARG) with cosolute arginine (ARG). The complex has been characterized for its apparent solubility and in vitro dissolution. The solid state characterization has been carried out using Fourier Transform Infra-Red (FTIR) Spectroscopy, Elemental Analysis, X-Ray Powder Diffraction (XRD), Differential Scanning Calorimetry (DSC) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscopy (SEM)...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28320456/thiolation-of-arabinoxylan-and-its-application-in-the-fabrication-of-controlled-release-mucoadhesive-oral-films
#6
Muhammad Hanif, Muhammad Zaman
BACKGROUND: Mucoadhesion is an important property that helps oral drug delivery system to remain attached with buccal mucosa and hence to improve the delivery of the drug. The current study was designed to achieve the thiol modification of Arabinoxylan (ARX) and to develop a mucoadhesive oral film for the improved delivery of tizanidine hydrochloride (TZN HCl). METHOD: Synthesis of thiolated arabinoxylan (TARX) was accomplished by esterification of ARX with thioglycolic acid (TGA)...
March 20, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28296422/quantum-dynamics-and-spectroscopy-of-ab-initio-liquid-water-the%C3%A2-interplay-of-nuclear-and-electronic-quantum-effects
#7
Ondrej Marsalek, Thomas E Markland
Understanding the reactivity and spectroscopy of aqueous solutions at the atomistic level is crucial for the elucidation and design of chemical processes. However, the simulation of these systems requires addressing the formidable challenges of treating the quantum nature of both the electrons and nuclei. Exploiting our recently developed methods that provide acceleration by up to 2 orders of magnitude, we combine path integral simulations with on-the-fly evaluation of the electronic structure at the hybrid density functional theory level to capture the interplay between nuclear quantum effects and the electronic surface...
March 22, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28291304/mitochondrial-dysfunction-in-calf-muscles-of-patients-with-combined-peripheral-arterial-disease-and-diabetes-type-2
#8
Brian Lindegaard Pedersen, Niels Bækgaard, Bjørn Quistorff
BACKGROUND: This study elucidate the effects on muscle mitochondrial function in patients suffering from combined peripheral arterial disease (PAD) and type 2 diabetes (T2D) and the relation to patient symptoms and treatment. METHODS: Near Infra Red Spectroscopy (NIRS) calf muscle exercise tests were conducted on Forty subjects, 15 (PAD), 15 (PAD+T2D) and 10 healthy age matched controls (CTRL) recruited from the vascular outpatient clinic at Gentofte County Hospital, Denmark...
March 14, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28278776/novel-application-of-high-density-polyethylene-mesh-as-self-forming-dynamic-membrane-integrated-into-a-bioreactor-for-wastewater-treatment
#9
P Sreeda, A B Sathya, V Sivasubramanian
In the present study, self-forming dynamic membrane (SFDM) on rigid high-density polyethylene (HDPE) mesh with a large pore size of 2 mm is reported for the first time. The system was investigated for utilisation in simulated wastewater treatment by integrating the mesh with an aerobic bioreactor. The SFDM was analysed using Fourier transform infra-red (FT-IR) spectroscopy and visualised by scanning electron microscopy (SEM). The effect of the operating parameter on the change in composition of SFDM was also investigated...
February 28, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28268593/multimodal-characterization-of-radiologically-detectable-lung-lesions
#10
Atasi Sarkar, A Sadhu, S Basu Thakur, S Sengupta, A Mukherjee, Jyotirmoy Chatterjee
Diagnosing radiologically detectable lung lesions on the basis of cyto/histopathological staining often suffers from ambiguity, leading to faulty detection of lung diseases, especially cancer. Present study attempted to perform a multimodal characterzation of clinical samples from patients with radiologically detected lung lesions, in order to classify diseases with higher precision. The study included analysing nuclear morphometric and intensity based differences between benign and malignant lung lesions in a quantitative way...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28258037/the-role-of-zinc-deficiency-induced-changes-in-the-phospholipid-protein-balance-of-blood-serum-in-animal-depression-model-by-raman-ftir-and-uv-vis-spectroscopy
#11
J Depciuch, M Sowa-Kućma, G Nowak, B Szewczyk, U Doboszewska, M Parlinska-Wojtan
Depression is a serious mental illness. To study the mechanisms of diseases and search for new, more effective therapies, animal models are used. Unfortunately, none of the available models does reflect all symptoms of depression. Zinc deficiency is proposed as a new animal model of depression. However, it has not been yet validated in a detailed manner. Recently, spectroscopic techniques are increasingly being used both in clinical and preclinical studies. Here we examined the effect of zinc deficiency and amitryptyline treatment on the phospholipid - protein balance in the blood serum of rats using Raman, Fourier Transform Infra Red (FTIR) and UV-vis technique...
February 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28245225/facile-synthesis-of-light-harvesting-semiconductor-bismuth-oxychloride-nano-photo-catalysts-for-efficient-removal-of-hazardous-organic-pollutants
#12
Zaki S Seddigi, Mohammed A Gondal, Umair Baig, Saleh A Ahmed, M A Abdulaziz, Ekram Y Danish, Mazen M Khaled, Abul Lais
In the present work, bismuth oxychloride nanoparticles-a light harvesting semiconductor photocatalyst-were synthesized by a facile hydrolysis route, with sodium bismuthate and hydroxylammonium chloride as the precursor materials. The as-synthesized semiconductor photocatalysts were characterized using X-ray diffraction analysis, Fourier transform infra-red spectroscopy, Raman spectroscopy, Field emission scanning electron microscopy, X-ray photoelectron spectroscopy and Photoluminescence spectroscopy techniques...
2017: PloS One
https://www.readbyqxmd.com/read/28233399/probing-the-mechanism-of-interaction-of-metoprolol-succinate-with-human-serum-albumin-by-spectroscopic-and-molecular-docking-analysis
#13
Suma K Pawar, Seetharamappa Jaldappagari
In the present work, the mechanism of the interaction between a β1 receptor blocker, metoprolol succinate (MS) and human serum albumin (HSA) under physiological conditions was investigated by spectroscopic techniques, namely fluorescence, Fourier transform infra-red spectroscopy (FT-IR), fluorescence lifetime decay and circular dichroism (CD) as well as molecular docking and cyclic voltammetric methods. The fluorescence and lifetime decay results indicated that MS quenched the intrinsic intensity of HSA through a static quenching mechanism...
February 24, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28231130/evaluation-of-turmeric-powder-adulterated-with-metanil-yellow-using-ft-raman-and-ft-ir-spectroscopy
#14
Sagar Dhakal, Kuanglin Chao, Walter Schmidt, Jianwei Qin, Moon Kim, Diane Chan
Turmeric powder (Curcuma longa L.) is valued both for its medicinal properties and for its popular culinary use, such as being a component in curry powder. Due to its high demand in international trade, turmeric powder has been subject to economically driven, hazardous chemical adulteration. This study utilized Fourier Transform-Raman (FT-Raman) and Fourier Transform-Infra Red (FT-IR) spectroscopy as separate but complementary methods for detecting metanil yellow adulteration of turmeric powder. Sample mixtures of turmeric powder and metanil yellow were prepared at concentrations of 30%, 25%, 20%, 15%, 10%, 5%, 1%, and 0...
May 17, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28227297/features-of-cerebral-oxygenation-detects-brain-injury-in-premature-infants
#15
John M O'Toole, Mmoloki Kenosi, Daragh Finn, Geraldine B Boylan, Eugene M Dempsey, John M O'Toole, Mmoloki Kenosi, Daragh Finn, Geraldine B Boylan, Eugene M Dempsey, Daragh Finn, Eugene M Dempsey, Mmoloki Kenosi, John M Otoole, Geraldine B Boylan
Babies born prematurely can develop brain injury within days after birth. Early identification of high-risk infants enables appropriate clinical care to mitigate potential lifelong disabilities. Near infra-red spectroscopy is an established technology that can provide continuous measurements of cerebral oxygen saturation (rcSO2) over this critical period. We develop a feature set of the rcSO2 signal for the purpose of detecting brain injury. Our feature set contains amplitude, spectral, and fractal dimension features within 5 frequency bands...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226771/multimodal-characterization-of-radiologically-detectable-lung-lesions
#16
Atasi Sarkar, A Sadhu, S Basu Thakur, S Sengupta, A Mukherjee, Jyotirmoy Chatterjee, Atasi Sarkar, A Sadhu, S Basu Thakur, S Sengupta, A Mukherjee, Jyotirmoy Chatterjee, S Basu Thakur, A Mukherjee, Atasi Sarkar, S Sengupta, A Sadhu, Jyotirmoy Chatterjee
Diagnosing radiologically detectable lung lesions on the basis of cyto/histopathological staining often suffers from ambiguity, leading to faulty detection of lung diseases, especially cancer. Present study attempted to perform a multimodal characterzation of clinical samples from patients with radiologically detected lung lesions, in order to classify diseases with higher precision. The study included analysing nuclear morphometric and intensity based differences between benign and malignant lung lesions in a quantitative way...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28216875/antidermatophytic-and-protease-inhibiting-activities-of-zerumbone-a-natural-sesquiterpene-from-the-rhizome-of-zingiber-zerumbet-l-roscoe-ex-j-e-smith
#17
Madhavankutty Jyothilakshmi, Mathew Jyothis, Gokulanathan Nair Hari Narayanan, Mukalel Sankunni Latha
CONTEXT: Due to increase in the number of patients with impaired immunity, incidence of dermatophytoses has increased considerably. Antidermatophytic agents with anti-inflammatory and protease-inhibiting activities will help in restricting inflammatory response associated with dermatophytoses. AIMS: The present study aims to evaluate antidermatophytic and protease-inhibiting activities of zerumbone. Cytotoxicity was tested using Chang liver cell line as a preliminary step in toxicity study...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28130141/starch-based-xerogels-effect-of-acetylation-on-physicochemical-and-rheological-properties
#18
Chinwe U Kemas, Ndidi C Ngwuluka, Nelson A Ochekpe, Elijah I Nep
This study was aimed at evaluating the physicochemical and rheological properties of starch-based xerogels. The starch from the shoots of Borassus aethiopium was physically modified by xerogelization, and chemically by acetylation, and combination of acetylation and xerogelization. The solubility, swelling and syneresis of the starches were determined by gravimetric techniques. Evaluation of the native starch and derivatives was done using microscopy, Fourier transform infra-red (FTIR), x-ray diffractometry (XRD), and (1)H NMR spectroscopy...
January 24, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28081356/canna-edulis-leaf-extract-mediated-preparation-of-stabilized-silver-nanoparticles-characterization-antimicrobial-activity-and-toxicity-studies
#19
S V Otari, S H Pawar, Sanjay K S Patel, Raushan K Singh, Sang-Yong Kim, Jai Hyo Lee, Liaoyuan Zhang, Jung-Kul Lee
A novel approach to synthesize silver nanoparticles (AgNPs) using leaf extract of Canna edulis Ker-Gawl. (CELE) under ambient conditions is reported here. The as-prepared AgNPs were analyzed by UV-visible spectroscopy, transmission emission microscopy, X-ray diffraction, Fourier transform-infra red spectroscopy, energy-dispersive analysis of X-ray spectroscopy, zeta potential, and dynamic light scattering. The AgNPs showed excellent antimicrobial activity against various pathogens, including bacteria and various fungi...
January 12, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28065750/physicochemical-properties-and-biological-activities-of-novel-blend-films-using-oxidized-pectin-chitosan
#20
Asma Chetouani, Nadège Follain, Stéphane Marais, Christophe Rihouey, Meriem Elkolli, Mahmoud Bounekhel, Djafer Benachour, Didier Le Cerf
Pectin has been widely used in a variety of biomedical applications. In this study, it was modified with sodium periodate as an oxidant and characterized by physicochemical methods Periodate oxidation increased the contents of dialdehyde units and carboxyl groups in pectin, and a decrease in pectin viscosity was measured. The oxidization reaction led to a significant decrease in all values of molecular weight and size (Mn, Mw, [η] and Rh) as determined by size exclusion chromatography (SEC), which allowed the selection of the oxidized pectin to be added to chitosan...
April 2017: International Journal of Biological Macromolecules
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