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https://www.readbyqxmd.com/read/29224215/deleterious-variants-in-dchs1-are-prevalent-in-sporadic-cases-of-mitral-valve-prolapse
#1
Alisson Clemenceau, Jean-Christophe Bérubé, Paméla Bélanger, Nathalie Gaudreault, Maxime Lamontagne, Oumhani Toubal, Marie-Annick Clavel, Romain Capoulade, Patrick Mathieu, Philippe Pibarot, Yohan Bosse
BACKGROUND: A recent study identified DCHS1 as a causal gene for mitral valve prolapse. The goal of this study is to investigate the presence and frequency of known and novel variants in this gene in 100 asymptomatic patients with moderate to severe organic mitral regurgitation. METHODS: DNA sequencing assays were developed for two previously identified functional missense variants, namely p.R2330C and p.R2513H, and all 21 exons of DCHS1. Pathogenicity of variants was evaluated in silico...
December 10, 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29221743/ex%C3%A2-vivo-hydrodynamics-after-central-and-paracommissural-edge-to-edge-technique-a-further-step-toward-transcatheter-tricuspid-repair
#2
Sina Stock, Heidemarie Bohm, Michael Scharfschwerdt, Doreen Richardt, Roza Meyer-Saraei, Stanislav Tsvelodub, Hans-Hinrich Sievers
OBJECTIVES: Transcatheter approaches in heart valve disease became tremendously important and are currently established in the aortic position, but transcatheter tricuspid repair is still in its beginning and remains challenging. Replicating the surgical edge-to-edge technique, for example, with the MitraClip System (Abbott Vascular, Santa Clara, Calif), represents a promising option and has been reported successfully in small numbers of cases. However, up to now, few data considering the edge-to-edge technique as a transcatheter approach are available...
November 2, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29220425/a-leaflet-plication-clip-is-an-effective-surgical-template-for-mitral-valve-foldoplasty
#3
Isaac Wamala, Mossab Saeed, Sunil J Ghelani, Kimberlee Gauvreau, Peter E Hammer, Nikolay V Vasilyev, Pedro J Del Nido
OBJECTIVES: During mitral valve repair using the foldoplasty technique, correct judgement of the necessary dimensions and orientation of the leaflet fold is a critical but challenging step that can affect the chances of successful repair. In this study, we investigated whether a leaflet plication clip can be used to guide suture foldoplasty for posterior leaflet prolapse of the mitral valve. METHODS: Complete posterior leaflet prolapse was created in both in vivo and ex vivo pig hearts by severing the chordae supporting the middle scallop...
December 6, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29219861/sacrocolpopexy-with-concomitant-total-vs-supracervical-hysterectomy-functional-support-comparisons-in-cadavers
#4
Pedro Antonio Maldonado, Kyle P Norris, Maria E Florian-Rodriguez, Nemi M Shah, Clifford Y Wai
OBJECTIVE: This study aimed to compare the ability of abdominal sacrocolpopexy (ASC) with concomitant total vs supracervical hysterectomy to resist downward traction as a measure of functional anatomic support in human cadavers. METHODS: Supracervical hysterectomy was performed on unembalmed cadaver specimens, followed by ASC attaching polypropylene mesh to the posterior cervix/vagina only and then the anterior and posterior cervix/vagina. Using a metal bolt placed through the cervix tied to a filament passing through a fixed pulley system, successive weights of 0...
December 7, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29218698/risk-factors-of-overactive-bladder-syndrome-and-its-relation-to-sexual-function-in-menopausal-women
#5
Sevil Hakimi, Elham Aminian, Sakineh Mohammad- Alizadeh Charandabi, Parvin Bastani, Marzieh Mohammadi
BACKGROUND: Overactive bladder syndrome is a common and annoying complication worldwide that could negatively affect the quality of life of afflicted individuals. We aimed to determine the prevalence and risk factors of overactive bladder syndrome and its relation to sexual function in healthy menopausal women. METHODS: This cross-sectional study was done on 340 women aged 45-60 years in Tabriz, northwest Iran, during 2015-2016. Data were collected using a demographic data questionnaire, the Overactive Bladder Syndrome Score, and the McCoy Female Sexuality Questionnaire...
December 4, 2017: Urologia
https://www.readbyqxmd.com/read/29217925/prevalence-and-factors-associated-with-pelvic-organ-prolapse-among-pedestrian-back-loading-women-in-bench-maji-zone
#6
Andualem Henok
Background: It is common to see women carrying heavy loads on their back in developing countries including Ethiopia. This may have an effect on pelvic organ prolapse. The objective of this study was to determine prevalence and factors associated with pelvic organ prolapse among pedestrian back-loading women in Bench-MajiZone, 2016. Methods: The study was conducted in Bench-MajiZone, Southwest Ethiopia, from January to March 2016. Cross-sectional study design was employed...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29216501/smart-coils-for-intracranial-aneurysm-embolization-initial-outcomes
#7
Adeel Ilyas, Thomas J Buell, Ching-Jen Chen, Dale Ding, Daniel M S Raper, Davis G Taylor, Jennifer D Sokolowski, Kenneth C Liu
OBJECTIVES: Endovascular technology for the treatment of intracranial aneurysms continues to rapidly evolve. The SMART coil (Penumbra Inc., Alameda, CA, USA) is a novel microcoil designed to enhance deliverability. The aim of this single-center, retrospective cohort study is to assess the initial outcomes after aneurysm embolization using SMART coils. PATIENTS AND METHODS: We reviewed consecutive patients with intracranial aneurysms who underwent endovascular embolization using SMART coils from June 2016 to January 2017...
December 2, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29215517/two-year-results-of-burch-compared-with-midurethral-sling-with-sacrocolpopexy-a-randomized-controlled-trial
#8
Emanuel C Trabuco, Brian J Linder, Christopher J Klingele, Roberta E Blandon, John A Occhino, Amy L Weaver, Michaela E McGree, John B Gebhart
OBJECTIVE: To evaluate 1- and 2-year urinary continence rates after Burch retropubic urethropexy compared with a retropubic midurethral sling for women with urinary incontinence undergoing sacrocolpopexy. METHODS: We conducted a planned secondary analysis of a multicenter, randomized, single-blind trial comparing Burch with a sling that enrolled participants from June 2009 to August 2013. Objective outcome measures of continence were assessed at 1- and 2-year follow-up through office visits and validated questionnaires...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29214325/anterior-colporrhaphy-a-standard-operation-systematic-review-of-the-technical-aspects-of-a-common-procedure-in-randomized-controlled-trials
#9
REVIEW
Ksenia Halpern-Elenskaia, Wolfgang Umek, Barbara Bodner-Adler, Engelbert Hanzal
INTRODUCTION: Anterior colporrhaphy (AC) is considered a standard procedure and is performed all over the world. However, not a single step of the procedure has ever been truly standardized and the rates of failure show a wide range in the literature from 0% up to 92%. The aim of this systematic review was to evaluate the differences in technique and procedure worldwide. METHODS: We performed a systematic literature search up to March 2016 using the MeSH terms "(anterior AND (colporrhaph* or colporhaph* or repair* or cystocel*)" using Preferred Reporting Items for Sytematic Reviews and Meta-Analyses (PRISMA)...
December 6, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/29212782/trials-of-transvaginal-mesh-devices-for-pelvic-organ-prolapse-a-systematic-database-review-of-the-us-fda-approval-process
#10
Carl J Heneghan, Ben Goldacre, Igho Onakpoya, Jeffrey K Aronson, Tom Jefferson, Annette Pluddemann, Kamal R Mahtani
INTRODUCTION: Transvaginal mesh devices are approved in the USA by the Food and Drug Administration (FDA), through the 510(k) system. However, there is uncertainty about the benefit to harm balance of mesh approved for pelvic organ prolapse. We, therefore, assessed the evidence at the time of approval for transvaginal mesh products and the impact of safety studies the FDA mandated in 2012 because of emerging harms. METHODS: We used FDA databases to determine the evidence for approval of transvaginal mesh...
December 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/29212584/horner-syndrome-in-2-pigs-sus-scrofa-after-vascular-grafting-of-the-carotid-artery-and-jugular-vein
#11
Gabrielle C Musk, Martyn King, Bulang He
The term Horner syndrome refers to the clinical presentation of oculosympathoparesis, comprising miosis, ptosis, and facial anhydrosis. To date, there are 2 reports of postoperative Horner syndrome in pigs. In this species the cervical sympathetic chain and cranial cervical sympathetic ganglion are consistently within the carotid artery sheath. This case study describes the sudden onset of Horner syndrome in 2 pigs, from a study cohort of 8, after the placement of a vascular graft between the carotid artery and external jugular vein...
December 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/29212457/the-decision-delivery-interval-in-emergency-caesarean-section-and-its-associated-maternal-and-fetal-outcomes-at-a-referral-hospital-in-northern-tanzania-a-cross-sectional-study
#12
Birjna A Hirani, Bariki L Mchome, Nicholaus S Mazuguni, Michael J Mahande
BACKGROUND: Decision delivery interval (DDI) is the time line between a decision to conduct an emergency caesarean section and actual delivery of the baby. Prolong DDI constitute a third phase delay in provision of emergency obstetric care. Intervention designed to minimize DDI are vital, in attempt to prevent maternal morbidity and neonatal morbidity and mortality. The feasibility and practicability of the recommended DDI in recent studies have been questioned especially in limited resource setting and therefore the objective of our study was to determine the DDI and its associated fetalmaternal outcomes at a tertiary referral hospital in Tanzania...
December 7, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29210807/restoring-genital-hiatus-to-normative-values-after-apical-suspension-alone-versus-with-level-3-support-procedures
#13
Charelle M Carter-Brooks, Jerry L Lowder, Angela L Du, Erin S Lavelle, Lauren E Giugale, Jonathan P Shepherd
OBJECTIVE: The aim of the study was to evaluate postoperative genital hiatus after apical suspension procedures without a level 3 support procedure (L3SP), posterior repair, and perineorrhaphy, compared with normative-value genital hiatus of 3.4 cm. METHODS: This an analysis of a pre-existing retrospectively collected database that included all minimally invasive sacrocolpopexies and uterosacral ligament suspensions performed at a tertiary medical center from January 2009 to August 2015...
November 29, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29208859/an-evaluation-of-the-result-of-fenestration-and-discectomy-for-the-treatment-of-prolapsed-lumber-intervertrebal-disc-plid
#14
M A Islam, S I Akon, M Shamsuzzaman, M Asaduzzaman, S Akter, M A Awal, A H Mahboob, M S Islam, M M Rahman, R Ara, M K Alam, M R Ali
The aim of this study is to asses the result of fenestration and discectomy for the treatment of PLID. This Prospective quasi experimental study was conducted on 29 Patient of PLID with different ages at Dhaka Medical College Hospital (DMCH), Dhaka, Bangladesh from July 2014 to June 2016. Post Operative outcome was assessed through Modified Macnab Criteria & Visual Analogue Score (VAS). The mean age of patient were 38.14±9.20 years and ranging from 24 to 55 years. The mean age of male was 37.21±9.72 years and female patient was 39...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207889/primary-carcinosarcoma-of-the-vagina-associated-with-differentiated-squamous-intraepithelial-neoplasia-in-a-patient-with-complete-uterine-prolapse-case-report-and-review-of-the-literature
#15
Emina Babarović, Karla Sladoljev, Ena Perin, Marko Klarić, Ružica Karnjuš-Begonja, Tamara Sinožić, Morana Dinter, Lana Glavan Gačanin, Senija Eminović
Vaginal carcinosarcomas (VCSs) are rare and clinically aggressive neoplasms. Primary vaginal malignancies are among the rarest malignant tumors, so clear management guidelines and optimal therapy, especially in the presence of significant pelvic organ prolapse, has not been determined. Here, we present a case of primary VCS closely associated with differentiated squamous intraepithelial neoplasia (DSIN), from which it appeared to have arisen in a postmenopausal patient with complete uterine prolapse. The unusual presentation of our case with DSIN in the adjacent vaginal epithelium with possible diagnostic pitfalls emphasizes the need for systemic presentation of these cases to help pathologists and clinicians know that such lesions can initially present in a patient with complete uterine prolapse...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29207786/recurrent-vaginal-cuff-dehiscence-in-a-treated-case-of-carcinoma-cervix
#16
Sunesh Kumar, Seema Singhal, Yamini Kansal, Dayanand Sharma
Vaginal Cuff Dehiscence (VCD) is partial or total separation of anterior and posterior vaginal cuff layers. We report a case of recurrent vault cuff dehiscence in a patient of cervical carcinoma. A 60-year-old treated case of carcinoma cervix post surgery and radiotherapy was found to have vault dehiscence and intestinal prolapse second time during a routine speculum examination. She underwent an emergency laparotomy and closure of vault. Vaginal Cuff Dehiscence with Evisceration (VCDE) is a rare but potentially fatal complication following hysterectomy...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207080/effect-of-puerarin-on-collagen-metabolism-of-fibroblasts-in-pelvic-tissue-of-women-with-pelvic-organ-prolapse
#17
Yang Li, Li Hong, Cheng Liu, Jie Min, Shasha Hong, Ming Hu, Yang Zhao, Qing Yang, Jianming Tang, Songming He
The aim of the present study was to investigate the protective effect of puerarin on pelvic organ prolapse (POP) and the underlying mechanisms that regulate the metabolism of human parametrial ligament fibroblasts (HPLFs). HPLFs obtained from the pelvic tissue of patients with (n=10) or without (n=8) POP during hysterectomy were isolated by enzymatic digestion and subsequently identified by immunocytochemistry in a previous study of the authors. Following this, cultured HPLFs were treated with 0.01, 0.10 or 1...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29204362/incarcerated-prolapsed-ureterocele-after-midurethral-sling-in-women
#18
Patkawat Ramart
Stress urinary incontinence (SUI) is a common problem in women. Successful treatment is now mid urethral sling but it would be a cause of urethral obstruction. In this case report, a 50 years old woman presented with a huge introitus mass after 3 months of midurethral sling. The mass protruded from the urethra and could not be reduced. Emergency MRI of pelvis was demonstrated prolapsed ureterocele, single system of right ureter. Preoperative planning was cystoscopy and mass excision. The patient was preoperatively counseled that right ureteric reimplantation may be required...
January 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29201518/transobturator-four-arms-mesh-in-the-surgical-management-of-stress-urinary-incontinence-with-cystocele
#19
Hammouda Sherif, Tarek Soliman Othman, Amr Eldkhakhany, Hussein Elkady, Adel Elfallah
Objective: This study aims to evaluate safety and efficacy of four arms polypropylene mesh in the long- term follow-up in the management of stress urinary incontinence (SUI) associated with cystocele. Material and methods: This prospective study was conducted on 50 female patients with SUI associated with cystocele. Patients underwent placement of transobturator four-arms mesh implants. Stress incontinence was evaluated using cough stress test with and without prolapse reduction, Stamey's grading of SUI, the validated Arabic version of the International Consultation on Incontinence Questionnaire-Short Form and King Health Questionnaire forms...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29198547/pelvic-organ-prolapse
#20
EDITORIAL
Huann-Cheng Horng, Fa-Kung Lee, Peng-Hui Wang
No abstract text is available yet for this article.
November 30, 2017: Journal of the Chinese Medical Association: JCMA
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