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Female urinary incontinence

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https://www.readbyqxmd.com/read/28714578/efficacy-and-initial-safety-profile-of-cxcl12-treatment-in-a-rodent-model-of-urinary-sphincter-deficiency
#1
J Koudy Williams, Ashley Dean, Shannon Lankford, Karl-Erik Andersson
Disappointing results of skeletal muscle precursor cell (skMPC) therapy for women with intrinsic urinary sphincter deficiency (ISD) associated urinary incontinence has increased interest in alternative sphincter regenerative approaches. This study was to measure the safety and efficacy of the cell homing chemokine CXCL12 versus skMPCs in a rat model of ISD. Thirty-six adult female Sprague Dawley rats were divided into 6 treatment (Tx) conditions: (a) no ISD/noTx [Control]; (b) ISD/noTx; (c) ISD + skMPCs; (d) ISD + 3...
July 17, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28713996/downregulation-of-aqp2-in-the-anterior-vaginal-wall-is-associated-with-the-pathogenesis-of-female-stress-urinary-incontinence
#2
Zujuan Zhang, Pan Xu, Zhenwei Xie, Fengxian Shen, Ning Chen, Liming Yu, Ronghuan He
The pathogenesis of stress urinary incontinence (SUI) is unclear. Aquaporins (AQPs) are a family of transmembrane proteins that transport water and small solutes, including glycerol, across cell membranes. AQPs have been demonstrated to serve a role in skin hydration, cellular proliferation, migration, immunity, wound healing and vascular remodeling in multiple organs. Furthermore, studies have confirmed that abnormal synthesis and degradation of collagens in extracellular matrix (ECM) remodeling contributes to SUI, by altering normal tissue architecture and mechanical properties...
July 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28709886/five-year-follow-up-results-of-a-prospective-multicenter-study-in-overactive-bladder-subjects-treated-with-sacral-neuromodulation
#3
Steven Siegel, Karen Noblett, Jeffrey Mangel, Jason Bennett, Tomas L Griebling, Suzette E Sutherland, Erin T Bird, Craig Comiter, Daniel Culkin, Samuel Zylstra, Fangyu Kan, Kellie Chase Berg
OBJECTIVE: To evaluate therapeutic success rate, changes in quality of life (QOL) and safety with sacral neuromodulation (SNM) at 5 years after InterStim™ implant. Subjects with bothersome symptoms of overactive bladder (OAB) including urinary urge incontinence (UI) and/or urgency-frequency (UF), who had failed at least 1 anticholinergic medication and had at least 1 medication untried were included. METHODS: Therapeutic success was defined as a UI or UF response: ≥ 50% improvement in average leaks or voids/day or a return to normal voiding (<8 voids/day)...
July 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28709582/the-incidence-of-transfusion-and-associated-risk-factors-in-pelvic-reconstructive-surgery
#4
Lopa K Pandya, Courtney Lynch, Andrew F Hundley, Silpa Nekkanti, Catherine O Hudson
BACKGROUND: Almost 400,000 female pelvic reconstructive operations were performed in 2010 for urinary incontinence and pelvic organ prolapse in the United States, and it is likely that this will continue to increase each year. There is a lack of population-based data evaluating the risk of blood transfusion after urogynecologic procedures. OBJECTIVES: To assess the incidence of blood transfusion related to pelvic reconstructive surgery in a large national surgical quality database and to identify transfusion-associated risk factors...
July 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28705367/dynamic-magnetic-resonance-imaging-of-the-pelvic-floor
#5
Sindhura Alapati, Kedar Jambhekar
Pelvic floor dysfunction is a widespread condition affecting up to 50% of elderly women. It markedly compromises the quality of life owing to various disabling symptoms such as pelvic pain, pelvic organ prolapse, and urinary and fecal incontinence. Although age and female sex are the main risk factors, others include multiparity, obesity, and connective tissue disorders. Pelvic floor dysfunction is frequently multicompartmental, and failure to diagnose it accurately often leads to treatment failure. Dynamic pelvic floor magnetic resonance imaging is a robust tool that enables simultaneous visualization of the 3 pelvic floor compartments and is indispensable for precise preoperative evaluation...
June 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28689526/tension-free-vaginal-taping-in-pakistani-women-with-stress-urinary-incontinence
#6
Ayesha Saleem
OBJECTIVE: To evaluate the effectiveness and determine the peroperative and postoperative complications of tension-free vaginal tape (TVT) sling for urinary stress incontinence (USI) and contributing factors to complications. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Kidney Centre Postgraduate Institute, Karachi, from January 2009 to December 2010. METHODOLOGY: One hundred consecutive patients underwent TVT as per Ulmsten Technique for urinary stress incontinence and patients were followed for 3 years...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28676367/iatrogenic-pelvic-pain-surgical-and-mesh-complications
#7
REVIEW
Dominic Lee, John Chang, Philippe E Zimmern
Female stress urinary incontinence and pelvic organ prolapse are prevalent conditions in adult women. Among treatment alternatives, more traditional methods of surgical intervention have been supplanted by synthetic polypropylene mesh kits. However, novel complications with mesh-related exposure, pelvic pain alone or with dyspareunia, and increased incidence of revision surgeries, resulted in 2 FDA warnings on transvaginal mesh use for prolapse repair. This review examines the anatomy of the vagina and urethra, the etiology of pain related to mesh use, and the relevant surgical techniques for management of this complication along with their outcomes...
August 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/28673063/a-study-of-clinical-predictors-associated-with-intrinsic-sphincter-deficiency-in-women-with-stress-urinary-incontinence
#8
Kyung Kgi Park, Sung Dae Kim, Jung-Sik Huh, Young-Joo Kim
PURPOSE: Recently, intrinsic sphincter deficiency (ISD) has been identified as one important factor in the outcome of stress urinary incontinence (SUI) related surgery. Clinical factors that can predict ISD are uncommon. The aim of this study was to determine predictive clinical factors for ISD in female patients with SUI. METHODS: The patients were classified into 3 groups according to the value of Valsalva leak point pressure (VLPP)>90 cm H2O (anatomical incontinence, AI), between 61 and 90 cm H2O (equivocal, EV), and <60 cm H2O (ISD)...
June 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28673060/urethral-closure-pressure-at-stress-a-predictive-measure-for-the-diagnosis-and-severity-of-urinary-incontinence-in-women
#9
Anne-Cécile Pizzoferrato, Arnaud Fauconnier, Xavier Fritel, Georges Bader, Philippe Dompeyre
PURPOSE: Maintaining urinary continence at stress requires a competent urethral sphincter and good suburethral support. Sphincter competence is estimated by measuring the maximal urethral closure pressure at rest. We aimed to study the value of a new urodynamic measure, the urethral closure pressure at stress (s-UCP), in the diagnosis and severity of female stress urinary incontinence (SUI). METHODS: A total of 400 women without neurological disorders were included in this observational study...
June 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28673059/assessing-the-readjustable-sling-procedure-remeex-system-for-female-stress-urinary-incontinence-with-detrusor-underactivity
#10
Kwang Jin Ko, Yoon Seok Suh, Hyun Hwan Sung, Gyu Ha Ryu, Munjae Lee, Kyu-Sung Lee
PURPOSE: Many surgeons worry about postoperative voiding problems in patients with stress urinary incontinence (SUI) and detrusor underactivity (DU). This study hypothesized that adjusting the tension after surgery would benefit patients with DU, and therefore researchers evaluated the outcomes and quality of life of women with SUI and DU who underwent the readjustable sling procedure (Remeex). METHODS: The medical records of 27 patients who were treated with the Remeex system for SUI and DU between 2007 and 2013 were retrospectively analyzed...
June 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28669487/-functional-and-aesthetic-evaluation-of-sacrococcygeal-teratomas-not-everything-ends-with-surgery
#11
Vanesa Villamil, Oscar Girón Vallejo, María Fernández-Ibieta, Ángela Sánchez Sánchez, Paulo Y Reyes Ríos, Irene Martínez Castaño, Javier Rojas-Ticona, Ramón Ruiz Pruneda, José I Ruiz Jiménez
INTRODUCTION: Sacrococcygeal teratoma is the most common solid neonatal tumour. The improvement in survival has meant that postoperative sequelae can be diagnosed and treated. The aim of this article is to evaluate the long-term outcomes of patients treated in our centre. MATERIAL AND METHODS: Records of patients treated for a sacrococcygeal teratoma in our hospital from 1977 to 2014 were retrospectively reviewed. Personal data was collected and a telephone questionnaire was used to assess long-term bowel and urinary habits, as well as an aesthetic and functional self-assessment...
June 29, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28667697/sexual-and-regional-differences-in-myosin-heavy-chain-expression-in-the-rat-external-urethral-sphincter
#12
Toshiko Tsumori, Wakako Tsumiyama
The external urethral sphincter is a unique striated muscle surrounding the urethra that plays a crucial role in urinary continence, and a comprehensive understanding of its morphology is needed to determine the pathophysiology underlying urinary incontinence and find suitable therapies. Differences between the sexes and among species regarding the fiber types present remain controversial. This study used triple immunofluorescence labeling to visualize one slow (type 1) and two fast (types 2A and 2B) myosin isoforms in rat external urethral sphincters from both sexes...
July 1, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28666062/a-populational-based-survey-on-the-prevalence-incidence-and-risk-factors-of-urinary-incontinence-in-older-adults-results-from-the-sabe-study
#13
José Tadeu Nunes Tamanini, Letícia Valério Pallone, Marair Grácio Ferreira Sartori, Manoel João Batista Castello Girão, Jair Lício Ferreira Dos Santos, Yeda Aparecida de Oliveira Duarte, Philip E V A van Kerrebroeck
AIMS: To estimate the prevalence and incidence of urinary incontinence (UI) and identify the associated risk factors in a cohort of elderly individuals in Brazil. METHODS: In 2006, individuals aged ≥60 years were selected from the SABE Study (Health, Well-being, and Aging). The dependent variable was reported UI in 2009. UI was assessed using the International Consultation on Incontinence Questionnaire Urinary Incontinence-Short Form (ICIQ-UI SF). Incidence was measured in units of 1000 person-years, and Cox regression was applied for data analysis...
June 30, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28661785/effect-of-pulsed-magnetic-stimulation-on-sexual-function-in-couples-with-female-stress-urinary-incontinence-partners
#14
Renly Lim, Men Long Liong, Yong Khee Lau, Wing Seng Leong, Nurzalina Abdul Karim Khan, Kah Hay Yuen
We prospectively evaluated the effects of pulsed magnetic stimulation (PMS) on sexual function of couples with stress urinary incontinence (SUI) partners. Female SUI subjects received 16 or 32 biweekly PMS sessions depending on treatment response. Prior to, immediately after and at 6-months post-treatment, couples completed the Golombok Rust Inventory of Sexual Satisfaction (GRISS) questionnaire. Fifty-three (80.3%) of 66 couples completed reassessments. Based on the overall GRISS score, there were significant improvements in sexual function in both female subjects (Mdiff -5...
June 29, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28660723/outcomes-of-treatment-of-stress-urinary-incontinence-associated-with-female-urethral-diverticula-a-selective-approach
#15
Alyssa Greiman, Lauren Rittenberg, Drew Freilich, Ross Rames, Ahmed El-Zawahry, Michelle Koski, Eric Rovner
AIMS: To assess surgical outcomes of concomitant treatment of SUI at time of transvaginal urethral diverticulectomy (TVUD) based on a selective approach. METHODS: Following Institutional Review Board (IRB) approval, we identified patients with a UD and SUI who underwent TVUD between July 2004 and January 2016. SUI was documented before and after surgery using subjective and objective parameters. Autologous pubovaginal slings (APVS) were used selectively based on surgeon and patient preference...
June 29, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28660675/objectively-improving-appropriateness-of-absorbent-products-provision-to-patients-with-urinary-incontinence-the-diapper-study
#16
Emilio Sacco, Riccardo Bientinesi, Carlo Gandi, Giuseppe Palermo, Francesco Pierconti, Pierfrancesco Bassi
AIMS: To objectively assess and enhance the appropriateness of continence products provision to sufferers from urinary incontinence (UI) managed with containment strategies. METHODS: Incontinent patients of five Italian continence care services were included in this industry-supported study from 01/2012 to 03/2016. All patients/carers have been invited to perform a 48-h home-based pad test and to fill in a diary. The primary outcome was the product appropriateness defined as the use of a pad with maximum absorbent capacity (MAC) from 30% to 50% higher than the individually measured urine load...
June 29, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28657990/urinary-incontinence-in-pregnant-young-women-and-adolescents-an-unrecognized-at-risk-group
#17
Marjorie Jean-Michel, Jessica Kroes, Guillermo A Marroquin, Emily Man-Shan Chau, Carolyn M Salafia, Magdy Mikhail
OBJECTIVES: The aims of this study were to determine the prevalence of urinary incontinence (UI) in pregnant young women and adolescents, characterize UI subtype, and identify characteristics associated with UI. METHODS: This was a cross-sectional study of pregnant females aged 25 years or below, presenting for routine obstetrical care at a New York City community hospital. Subjects were stratified into 2 groups: adolescents (age, ≤19 years) and young adults (age, >19 years)...
June 27, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28657986/the-truth-behind-transvaginal-mesh-litigation-devices-timelines-and-provider-characteristics
#18
Colby P Souders, Karyn S Eilber, Lynn McClelland, Lauren N Wood, Alexander R Souders, Vicki Steiner, Jennifer Tash Anger
OBJECTIVES: Following Food and Drug Administration communications about the safety of transvaginal prolapse, more than 73,000 patients with complications from treatment of pelvic organ prolapse (POP) or stress urinary incontinence (SUI) have filed product liability claims. This research analyzes the transvaginal mesh claims filed in the United States to identify key characteristics that may inform clinical decision-making. METHODS: We evaluated a 1% random sample from the Bloomberg Law Database: 2000 to 2014 and associated legal documents...
June 27, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28652167/effects-of-urinary-incontinence-subtypes-on-women-s-sexual-function-and-quality-of-life
#19
Salvatore Caruso, Roberta Brescia, Maria Grazia Matarazzo, Giuliana Giunta, Agnese Maria Chiara Rapisarda, Antonio Cianci
OBJECTIVES: To evaluate the effects of different subtypes of UI on sexual function and quality of life (QoL). MATERIALS AND METHODS: 93 women with UI were enrolled in the observational study. By the urodynamic findings, 32 women (34.5 %) were diagnosed with stress urinary incontinence (SUI), 35 (37.6%) with urgency urinary incontinence (UUI), and 26 (27.9%) with mixed urinary incontinence (MUI). The SF-36 questionnaire was used to investigate the quality of life (QoL), and the Female Sexual Function Index (FSFI) and Female Sexual Distress Scale (FSDS) questionnaires were used to study the sexual function and sexaul distress, respectively...
June 23, 2017: Urology
https://www.readbyqxmd.com/read/28651995/-placement-of-tension-free-vaginal-tape-in-women-with-stress-urinary-incontinence-long-term-functional-outcomes-in-a-prospective-series
#20
Q Manach, M Bouquot, M Rouprêt, V Ambrogi, F Richard, M O Bitker, E Chartier-Kastler, V Phé
PURPOSE: To evaluate the long-term functional outcomes after retropubic tension-free vaginal tape (TVT) placement to treat female stress urinary incontinence (SUI). METHODS: From September 1998 to September 2000, we prospectively enrolled all consecutive women in our center suffering SUI caused by urethral hypermobility. All women had a retropubic TVT inserted by the same surgeon. Patients were evaluated at 1, 3, 6 and 12 months postoperatively, and annually thereafter...
June 23, 2017: Progrès en Urologie
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