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Late Onset Hypogonadism

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https://www.readbyqxmd.com/read/27866050/boucher-neuh%C3%A3-user-syndrome-a-rare-cause-of-inherited-hypogonadotropic-hypogonadism-a-case-of-two-adult-siblings-with-two-novel-mutations-in-pnpla6
#1
Jakob H Langdahl, Anja L Frederiksen, Nina Nguyen, Klaus Brusgaard, Claus B Juhl
Boucher Neuhäuser Syndrome (BNS) is a rare clinical syndrome with autosomal recessive inheritance defined by early-onset ataxia, hypogonadism and chorioretinal dystrophy. We present two siblings diagnosed with BNS in late adult life identified with compound heterozygous state of two novel PNPLA6 mutations. Five healthy siblings were non- or heterozygous carriers of the mutations. The cases, which presented with ataxia in childhood and hypogonadotropic hypogonadism (HH), were diagnosed at age 17 and 25, respectively, when examined for delayed puberty...
November 16, 2016: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27857837/autoimmune-polyendocrinopathy-and-hypophysitis-after-puumala-hantavirus-infection
#2
Marlene Tarvainen, Satu Mäkelä, Jukka Mustonen, Pia Jaatinen
: Puumala hantavirus (PUUV) infection causes nephropathia epidemica (NE), a relatively mild form of haemorrhagic fever with renal syndrome (HFRS). Hypophyseal haemorrhage and hypopituitarism have been described in case reports on patients with acute NE. Chronic hypopituitarism diagnosed months or years after the acute illness has also been reported, without any signs of a haemorrhagic aetiology. The mechanisms leading to the late-onset hormonal defects remain unknown. Here, we present a case of NE-associated autoimmune polyendocrinopathy and hypopituitarism presumably due to autoimmune hypophysitis...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27849376/clomiphene-citrate-in-the-treatment-of-idiopathic-or-functional-hypogonadotropic-hypogonadism-in-men-a-case-series-and-review-of-the-literature
#3
Yair Liel
OBJECTIVE: Late onset hypogonadotropic hypogonadism (LOH) is a complex, heterogeneous entity. Whenever treatment is indicated, the endocrine literature has recommend testosterone replacement. We present our experience with clomiphene citrate (CC) treatment in patients with LOH and a review of the literature. DESIGN: A retrospective case series. PATIENTS AND MEASUREMENTS: Eighteen male patients with hypogonadotropic hypogonadism, roughly according to the EMAS criteria for LOH, attended at an academic hospital outpatient clinic...
November 16, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27831823/aging-and-sex-hormones-in-males
#4
Maria Chiara Decaroli, Vincenzo Rochira
Several large cohort studies have disclosed the trajectories of sex steroids changes overtime in men and their clinical significance. In men the slow, physiological decline of serum testosterone (T) with advancing age overlaps with the clinical condition of overt, pathological hypogonadism. In addition, the increasing number of comorbidities, together with the high prevalence of chronic diseases, all further contribute to the decrease of serum T concentrations in the aging male. For all these reasons both the diagnosis of late-onset hypogonadism (LOH) in men and the decision about starting or not T replacement treatment remain challenging...
November 10, 2016: Virulence
https://www.readbyqxmd.com/read/27778105/can-early-clinical-parameters-predict-post-traumatic-pituitary-dysfunction-in-severe-traumatic-brain-injury
#5
O Nemes, N Kovacs, Sz Szujo, B Bodis, L Bajnok, A Buki, T Doczi, E Czeiter, E Mezosi
BACKGROUND: Post-traumatic hypopituitarism is a major complication after severe head trauma. The aim of our study was to evaluate the possible role of early clinical parameters in the development of endocrine deficits. METHODS: Data on endocrine function, on-admission clinical-, laboratory-, and ICU-monitored parameters were available in 63 patients of the surviving 86 severe head injury patients (post-resuscitation GCS under 8) treated at one neurosurgical center during a 10-year period...
October 25, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27734705/-testosterone-and-mortality
#6
Luboslav Stárka
Subnormal levels of testosterone are frequently found in men of higher age category. Hypogonadal men have lower life expectancy than men with full androgenization and cardiovascular disease, obesity or diabetes is often associated with hypotestosteronemia. Low testosterone level is risk factor for these diseases. However, until now it is not clear whether testosterone deficiency is a cause or consequence of atherosclerosis or metabolic syndrome. A handful of symptoms and metabolic risk markers in hypogonadal men can be ameliorated by testosterone supplementation...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27732978/prevalence-of-late-onset-hypogonadism-in-men-with-localized-and-metastatic-renal-cell-carcinoma
#7
Bernhard Ralla, Ahmed Magheli, Ingmar Wolff, Barbara Erber, Irena Goranova, Frank Friedersdorff, Stefan Hinz, Carsten Kempkensteffen, Kurt Miller, Jonas Busch
BACKGROUND: Cancer-related fatigue is a common symptom in patients with renal cell carcinoma (RCC) and can be similar to the fatigue found in late-onset hypogonadism (LOH). The aim of this study was to investigate the prevalence of LOH in patients with localized RCC (loRCC) and metastatic RCC (mRCC) disease under targeted therapy (TT) and compare the results to findings of epidemiologic studies. METHODS: A total of 51 mRCC patients under TT and 33 patients with loRCC undergoing nephrectomy were included...
October 13, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27714896/comparing-calculated-free-testosterone-with-total-testosterone-for-screening-and-diagnosing-late-onset-hypogonadism-in-aged-males-a-cross-sectional-study
#8
Zhangshun Liu, Jie Liu, Xiaohong Shi, Lihong Wang, Yan Yang, Minfang Tao, Qiang Fu
OBJECTIVE: The aim of this study is to compare calculated free testosterone (cFT) and total testosterone (T) in predicting late-onset hypogonadism (LOH) in middle-aged and elderly males. METHODS: We surveyed a random sample of 608 males between the ages of 45 and 87 years from Shanghai, China. The Aging Male Symptoms (AMS) questionnaire and the Androgen Deficiency in Aging Male (ADAM) questionnaire were completed by the subjects. Testosterone (T), sex hormone-binding globulin (SHBG), albumin, and other blood biochemical indexes were measured in 332 males...
October 7, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27690744/rigiscan-data-under-long-term-testosterone-therapy-improving-long-term-blood-circulation-of-penile-arteries-penile-length-and-girth-erectile-function-and-nocturnal-penile-tumescence-and-duration
#9
Onder Canguven, Raidh A Talib, Walid El-Ansari, Ahmed Shamsoddini, Mahmoud Salman, Abdulla Al-Ansari
BACKGROUND: Late-onset hypogonadism (LOH) presents with low serum testosterone (TT) levels and sexual and nonsexual symptoms. Erectile dysfunction affects a man's self-esteem and as a result partner relationship and quality of life. OBJECTIVES: To investigate the andrological clinical profile outcomes of testosterone therapy (TTh) in men (n = 88) with symptomatic LOH complaints and symptoms. MAIN OUTCOME MEASURES: Erectile function was assessed using the International Index of Erectile Function-5 questionnaire at baseline and at 6 and 12 months of TTh...
October 1, 2016: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/27622282/clomiphene-citrate-treatment-for-late-onset-hypogonadism-rise-and-fall
#10
Marcelo Marconi, Renato Souper, Jonathan Hartmann, Matías Alvarez, Ignacio Fuentes, Francisco J Guarda
OBJECTIVE: Previous series have demonstrated that Clomiphene Citrate (CC) is an effective treatment to increase Total Testosterone (TT) in Late Onset Hypogonadism (LOH) patients. However, what happens to TT levels after ending CC treatment is still debatable. The objective of this study is to evaluate TT levels 3 months after the discontinuation of CC in patients with LOH who were previously successfully treated with the same drug. MATERIALS AND METHODS: Twenty-seven patients with LOH that were successfully treated (achieved TT levels >11nmol/l) with CC 50mgs daily for 50 days were prospectively recruited in our Andrological outpatient clinic...
November 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27470300/the-testicular-hormones-amh-inhb-insl3-and-testosterone-can-be-independently-deficient-in-older-men
#11
Yih Harng Chong, Michael W Pankhurst, Ian S McLennan
BACKGROUND: Late-onset hypogonadism is symptomatically diverse and not fully explained by circulating testosterone level. The adult testes secrete four distinct hormones (testosterone, AMH, INSL3, and InhB) into the circulation. Testosterone and InhB have proven dynamic regulation, with limited information available for AMH and INSL3. During aging, there is cellular senescence, which may underlie the diversity of hypogonadism. This leads to the postulate that the relative levels (profile) of the four testicular hormones in older men are variable and cannot be evaluated by the measurement of one hormone...
July 28, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27436076/effects-of-8-year-treatment-of-long-acting-testosterone-undecanoate-on-metabolic-parameters-urinary-symptoms-bone-mineral-density-and-sexual-function-in-men-with-late-onset-hypogonadism
#12
Sompol Permpongkosol, Kalayanee Khupulsup, Supatra Leelaphiwat, Sarawan Pavavattananusorn, Supranee Thongpradit, Thanom Petchthong
INTRODUCTION: The long-term effects of long-acting testosterone undecanoate (TU) and androgen receptor CAG repeat lengths in Thai men with late-onset hypogonadism (LOH) have not been reported. AIM: To analyze the 8-year follow-up effects of intramuscular TU therapy on metabolic parameters, urinary symptoms, bone mineral density, and sexual function and investigate CAG repeat lengths in men with LOH. METHODS: We reviewed the medical records of 428 men with LOH who had been treated with TU and 5 patients were diagnosed with prostate cancer during TU therapy...
August 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27427553/exercise-improves-the-effects-of-testosterone-replacement-therapy-and-the-durability-of-response-after-cessation-of-treatment-a-pilot-randomized-controlled-trial
#13
Dae-Yeon Cho, Jeong Kyun Yeo, Seung Ik Cho, Jae Eun Jung, Sang Jin Yang, Doo Hwan Kong, Jeong Ku Ha, Jin Goo Kim, Min Gu Park
The effects of the combination of exercise and TRT on symptoms of late-onset hypogonadism (LOH) and the durability of response after cessation of TRT were investigated. A total of fifty patients with erectile dysfunction (ED) who had a sedentary lifestyle and low serum total testosterone (T) levels were enrolled and followed for 20 weeks. Patients were randomly divided into two groups; all of them received T gel for 12 weeks and it was discontinued for 8 weeks. Patients assigned to Group II were offered a supervised exercise program for 20 weeks...
July 12, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27389320/testosterone-replacement-therapy-improves-health-related-quality-of-life-for-patients-with-late-onset-hypogonadism-a-meta-analysis-of-randomized-controlled-trials
#14
Y Nian, M Ding, S Hu, H He, S Cheng, L Yi, Y Li, Y Wang
Although testosterone replacement therapy can restore serum testosterone concentrations to normal level in late-onset hypogonadism patients, whether it can improve patients' quality of life remains uncertain. Therefore, we perform a meta-analysis of randomized controlled trials on this issue. Five randomized controlled trials total 1,212 patients were included. Fixed-effect model was used to calculate the weighted mean difference of score of Aging Males' Symptom rating scale. Our result reveals that testosterone replacement therapy improves patients' health-related quality of life in terms of the decrease in the AMS total score [WMD = -2...
July 8, 2016: Andrologia
https://www.readbyqxmd.com/read/27375998/applying-machine-learning-techniques-to-the-identification-of-late-onset-hypogonadism-in-elderly-men
#15
Ti Lu, Ya-Han Hu, Chih-Fong Tsai, Shih-Ping Liu, Pei-Ling Chen
In the diagnosis of late-onset hypogonadism (LOH), the Androgen Deficiency in the Aging Male (ADAM) questionnaire or Aging Males' Symptoms (AMS) scale can be used to assess related symptoms. Subsequently, blood tests are used to measure serum testosterone levels. However, results obtained using ADAM and AMS have revealed no significant correlations between ADAM and AMS scores and LOH, and the rate of misclassification is high. Recently, many studies have reported significant associations between clinical conditions such as the metabolic syndrome, obesity, lower urinary tract symptoms, and LOH...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27364544/plasma-mirna-expression-profile-in-the-diagnosis-of-late-onset-hypogonadism
#16
Nicholas Russell, Mathis Grossmann
No abstract text is available yet for this article.
September 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27346318/-treatment-of-osteoporosis-in-hypogonadal-men
#17
Ken Marumo, Kenichi Hata, Jun Hagiuda
About 3million men have been reported to have osteoporosis in Japan. One of known causes of osteoporosis in men is late-onset-hypogonadism. Androgen replacement therapy has been reporte to be effective in seveal literatures, however, patitiets should be excluded if prostate cancer is suspected. Addition of bisphosphpnate and active vitain D derivatives are recommended.
July 2016: Clinical Calcium
https://www.readbyqxmd.com/read/27346312/-early-onset-and-late-onset-male-hypogonadotropic-hypogonadism-and-osteoporosis
#18
Hiroshi Okada, Takeshi Shin, Yoshitomo Kobori
Hypogonadism is classified into two major clinical entities, namely early-onset hypogonadism and late-onset hypogonadism. The former is characterized by the malfunction of hypothalamo-pituitary-gonadal(testicular)axis or by the primary hypofunction of testes(e.g. Klinefelter's syndrome). The latter is summarized as LOH syndrome which is attributed to the dropped level of bioavailable testosterone. In these diseases testosterone is the key molecule which may cause various symptoms relating not only to physical health but also to mental or psychologic health...
July 2016: Clinical Calcium
https://www.readbyqxmd.com/read/27346308/-age-related-changes-in-androgen-and-bone-metabolism
#19
Sumito Ogawa, Masahiro Akishita
Decline of androgen level is involved in symptoms of late-onset hypogonadism in aging male, and recent findings suggest that it is also associated with osteoporosis, sarcopenia. Diagnosis and therapeutic intervention against osteoporosis in men is important for preventing from subsequent disability and frailty in elderly population.
July 2016: Clinical Calcium
https://www.readbyqxmd.com/read/27340554/gut-endotoxin-leading-to-a-decline-in-gonadal-function-gelding-a-novel-theory-for-the-development-of-late-onset-hypogonadism-in-obese-men
#20
Kelton Tremellen
Obesity is an increasing public health problem, with two-thirds of the adult population in many Western countries now being either overweight or obese. Male obesity is associated with late onset hypogonadism, a condition characterised by decreased serum testosterone, sperm quality plus diminished fertility and quality of life. In this paper we propose a novel theory underlying the development of obesity related hypogonadism- the GELDING theory (Gut Endotoxin Leading to a Decline IN Gonadal function). Several observational studies have previously reported an association between obesity related hypogonadism (low testosterone) and systemic inflammation...
2016: Basic and Clinical Andrology
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