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Late Onset Hypogonadism

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https://www.readbyqxmd.com/read/29746252/establishing-normal-values-of-total-testosterone-in-adult-healthy-men-by-the-use-of-four-immunometric-methods-and-liquid-chromatography-mass-spectrometry
#1
Giacomo Montagna, Samuela Balestra, Federica D'Aurizio, Francesco Romanelli, Cinzia Benagli, Renato Tozzoli, Lorenz Risch, Luca Giovanella, Mauro Imperiali
BACKGROUND: The total testosterone (T) cutoffs clinically adopted to define late-onset hypogonadism (LOH) do not consider the differences that exist between different analytical platforms, nor do they consider the body mass index (BMI) or age of the patient. We aimed at providing method, age and BMI-specific normal values for total T in European healthy men. METHODS: A total of 351 eugonadal healthy men were recruited, and total T was measured with four automated immunometric assays (IMAs): ARCHITECT i1000SR (Abbott), UniCel DxI800 (Beckman Coulter), Cobas e601 (Roche), IMMULITE 2000 (Siemens) and liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
May 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29734846/the-efficacy-and-safety-of-short-acting-testosterone-ointment-glowmin-for-late-onset-hypogonadism-in-accordance-with-testosterone-circadian-rhythm
#2
Toshiyasu Amano, Teruaki Iwamoto, Yoshikazu Sato, Tetsuya Imao, Carolyn Earle
INTRODUCTION: It is well known that there is a reduction of circadian rhythm in blood testosterone levels with aging. Our previous report revealed that 3 mg of short-acting testosterone ointment (Glowmin: GL) elevated serum testosterone levels to within the physiological range for 4-6 h. The aim of this study was to clarify the clinical efficacy and safety of GL used topically once every morning, to enhance the circadian rhythm of testosterone, for late-onset hypogonadism (LOH). METHODS: A total of 61 LOH patients received 3 mg of GL topically once a day in the morning on scrotal skin for 24 weeks...
May 8, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29720027/efficacy-of-testosterone-treatment-in-hemodialysis-patients-as-assessed-by-aging-males-symptoms-scores-a-pilot-study
#3
Yasuyuki Inoue, Kenzo Nakamura, Yoshitaka Kuwahara, Yan Lu, Nanako Masuda, Shigeo Horie, Hiroshi Okada, Hisamitsu Ide
Numerous reports point to the beneficial effects of testosterone replacement therapy for patients with late-onset hypogonadism (LOH) syndrome. The aim of this study was to evaluate the effect of intramuscular injection of testosterone enantholactam acid ester on Aging Males' Symptoms (AMS) scores in hemodialysis patients with LOH. A total of 24 male patients with LOH (total AMS scores ≥27) were randomized into groups receiving intramuscular injections of either placebo or testosterone enantholactam acid ester at the dose of 250 mg for 6 months...
May 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29706560/androgen-receptor-cag-repeat-length-as-a-risk-factor-of-late-onset-hypogonadism-in-a-korean-male-population
#4
Jong Wook Kim, Young Dae Bae, Sun Tae Ahn, Jin Wook Kim, Je Jong Kim, Du Geon Moon
BACKGROUND: Testosterone action is mediated through the androgen receptor (AR), whose sensitivity is influenced by the AR CAG repeat polymorphism. However, the relation between late-onset hypogonadism (LOH) and AR CAG repeat length is unclear and studies of Asian populations are limited. AIM: To investigate the relation between AR CAG repeat length and LOH in Korean men. METHODS: 263 Korean men (mean age = 63.43 ± 10.9 years) were enrolled from 2014 to 2015...
April 26, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29706034/emerging-evidences-in-the-long-standing-controversy-regarding-testosterone-replacement-therapy-and-cardiovascular-events
#5
REVIEW
Jonathan Clavell-Hernández, Run Wang
The increasing rate of late-onset hypogonadism has led to an exceptional growth in the use of testosterone therapy (TTh). Even though TTh has been used for more than 70 years, there has been an emerging controversy in the past several years regarding its safety due to a suggested increased risk of cardiovascular (CV) disease among its users. Given the growing prevalence of testosterone deficiency in our population and the increased use of TTh, the goal of this review is to present the history and emerging evidence in regards to this controversy...
May 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29670654/toxicities-associated-with-cisplatin-based-chemotherapy-and-radiotherapy-in-long-term-testicular-cancer-survivors
#6
REVIEW
Chunkit Fung, Paul Dinh, Shirin Ardeshir-Rouhani-Fard, Kerry Schaffer, Sophie D Fossa, Lois B Travis
Testicular cancer has become the paradigm of adult-onset cancer survivorship, due to the young age at diagnosis and 10-year relative survival of 95%. This clinical review presents the current status of various treatment-related complications experienced by long-term testicular cancer survivors (TCS) free of disease for 5 or more years after primary treatment. Cardiovascular disease and second malignant neoplasms represent the most common potentially life-threatening late effects. Other long-term adverse outcomes include neuro- and ototoxicity, pulmonary complications, nephrotoxicity, hypogonadism, infertility, and avascular necrosis...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29665142/risk-factors-for-late-onset-hypogonadism
#7
Q T Yang, K S Wu, Z J Li, W C Li, L Lu, H Q Wu, Y Y Zhuang, X X Sui
The European Male Aging Study (EMAS) has recently defined strict diagnostic criteria for late-onset hypogonadism (LOH) including the levels of serum total testosterone (TT), free testosterone (FT) and three sexual symptoms. However, there is no report on risk factors for LOH using these criteria. In this study, we investigated risk factors for LOH based on these criteria. We recruited 277 men (aged 36-80 years) who completed both a health check-up and two questionnaires (a health and lifestyle questionnaire, and a sexual function questionnaire)...
April 17, 2018: Andrologia
https://www.readbyqxmd.com/read/29618492/autophagy-regulates-testosterone-synthesis-by-facilitating-cholesterol-uptake-in-leydig-cells
#8
Fengyi Gao, Guoping Li, Chao Liu, Hui Gao, Hao Wang, Weixiao Liu, Min Chen, Yongliang Shang, Lina Wang, Jian Shi, Wenlong Xia, Jianwei Jiao, Fei Gao, Jian Li, Liang Chen, Wei Li
Testosterone is indispensable for sexual development and maintaining male characteristics, and deficiency of this hormone results in primary or late-onset hypogonadism (LOH). Testosterone is primarily produced in Leydig cells, where autophagy has been reported to be extremely active. However, the functional role of autophagy in testosterone synthesis remains unknown. In this study, we show that steroidogenic cell-specific disruption of autophagy influenced the sexual behavior of aging male mice because of a reduction in serum testosterone, which is similar to the symptoms of LOH...
April 4, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29616850/the-relationship-between-erectile-dysfunction-severity-mean-platelet-volume-and-vitamin-d-levels
#9
Mehmet Gokhan Culha, Hasan Anil Atalay, Halil Lutfi Canat, Ilter Alkan, Sait Ozbir, Osman Can, Alper Otunctemur
BACKGROUND: The aim of this study was to evaluate the relationship between mean platelet volume (MPV) and vitamin D levels according to ED severity. METHODS: Between October 2015 and September 2017, patients who applied to the andrology outpatient clinic with an ED complaint were retrospectively reviewed. Patients with diabetes, hypertension, hyperlipidemia, malignancy, late-onset hypogonadism and smokers were not included in the study. The International Erectile Function Index-Erectile Function (IIEF-EF) questionnaire was used to assess the levels of erectile function...
April 4, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29544222/hypothalamic-response-to-kisspeptin-and-pituitary-response-to-gnrh-are-preserved-in-healthy-older-men
#10
Ali Abbara, Shakunthala Narayanaswamy, Chioma Izzi-Engbeaya, Alexander N Comninos, Sophie Clarke, Zainab Malik, Deborah Papadopoulou, Ailish Clobentz, Zubair Sarang, Paul Bassett, Channa Jayasena, Waljit S Dhillo
<br>Background: Male testosterone levels decline by 1% per year from the age of 40yrs. Whilst a primary testicular deficit occurs, hypothalamic or pituitary dysregulation may also coexist. This study aimed to compare the hypothalamic response to kisspeptin and the pituitary response to GnRH of older men with those of young men. METHODS: Following 1 hour of baseline sampling, healthy older men (n=5, mean age 59.3±2.9yrs) received a 3 hour intravenous infusion (IVI) of either: vehicle, kisspeptin-54 0...
March 15, 2018: Neuroendocrinology
https://www.readbyqxmd.com/read/29505313/pharmacological-management-of-late-onset-hypogonadism
#11
REVIEW
Giulia Rastrelli, Mario Maggi, Giovanni Corona
The frequency of late-onset hypogonadism (LOH) ranges between 2 and 15%. Up to 85% of LOH is due to a functional impairment of the hypothalamus-pituitary-testicular axis, mostly secondary to metabolic conditions. Areas covered: This paper provides a comprehensive review of all the available medications for treating LOH, including antiestrogens, gonadotropins and testosterone therapy (TTh). In addition, the evidence on clinical outcomes of these treatments is provided by meta-analyzing the results from the available randomized clinical trials...
April 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29481720/the-set-protein-promotes-androgen-production-in-testicular-leydig-cells
#12
B Zhang, W Ma, Q Zhu, W Xu, L Gao, B Xu, S Xu, C Gao, L Gao, J Liu, Y Cui
Approximately 40% of middle-aged men exhibit symptoms of late-onset hypogonadism (LOH). However, the mechanism of androgen deficiency is still currently unclear. As shown in our previous studies, the SET protein is expressed in testicular Leydig cells and ovarian granule cells. This study was designed to investigate the effect of the SET protein on androgen production in Leydig cells. The AdCMV/SET and AdH1siRNA/SET adenoviruses were individually transduced into a cultured mouse Leydig cell line (mLTC-1) with or without human chorionic gonadotropin (HCG) stimulation in vitro...
February 26, 2018: Andrology
https://www.readbyqxmd.com/read/29478250/high-prevalence-of-hypogonadism-determined-by-serum-free-testosterone-level-in-japanese-testicular-cancer-survivors
#13
Masahiro Kurobe, Koji Kawai, Takahiro Suetomi, Teruaki Iwamoto, Natsui Waku, Takashi Kawahara, Takahiro Kojima, Akira Joraku, Jun Miyazaki, Hiroyuki Nishiyama
OBJECTIVE: Hypogonadism is a major complication in testicular cancer survivors, but its prevalence varies among studies. In Japan, free testosterone has been used for diagnosis of late-onset hypogonadism syndrome. In the present study, we evaluated the hormone level of testicular cancer survivors and its impact on their quality of life. METHODS: Overall, 50 testicular cancer survivors treated from 1990 to 2013 were enrolled. The median age was 44 years. The serum levels of free testosterone, total testosterone and luteinizing hormone were measured...
May 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29472893/late-onset-puberty-induction-by-transdermal-estrogen-in-turner-syndrome-girls-a-longitudinal-study
#14
Aneta Monika Gawlik, Magdalena Hankus, Kamila Szeliga, Aleksandra Antosz, Tomasz Gawlik, Kamil Soltysik, Agnieszka Drosdzol-Cop, Krzysztof Wilk, Grzegorz Kudela, Tomasz Koszutski, Ewa Malecka-Tendera
Objective: Estrogen replacement therapy (ERT) for Turner syndrome (TS) is a widely discussed topic; however, the optimal model of ERT for patients with delayed diagnosis and/or initiation of therapy is still unclear, mainly due to insufficient data. We present the results of a prospective observational single-center study in which the efficacy of late-onset puberty induction by one-regimen transdermal ERT in TS girls was evaluated. Methods: The analysis encompassed 49 TS girls (63...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29331623/male-sexual-dysfunction-and-hypogonadism-guidelines-for-the-aging-male
#15
Kamran Ahmed, Kostas Hatzimouratidis, Asif Muneer
Cognitive and somatiform changes occur with ageing and are often attributed to late-onset hypogonadism. Testosterone replacement in older men remains controversial despite increasing evidence of symptomatic and clinical benefit in relation to improvements in sexual dysfunction, muscle mass, and diabetic control. The controversial areas related to cardiovascular safety and risk of prostate cancer need to be considered.
October 2017: European Urology Focus
https://www.readbyqxmd.com/read/29303101/-testosterone-therapy-indications-and-risks
#16
M G F Maatje, M Dinkelman-Smit, W P A Boellaard, G R Dohle
- Late onset hypogonadism (LOH) is a shortage of testosterone in adult men whose male development was normal. This form of hypogonadism results in decreased testosterone levels and variable gonadotrophin levels. - The symptoms of LOH are often aspecific and may be consistent with ageing in men: lowered libido, loss of strength, reduced cognitive functioning and disorders of sleeping and mood. - There is discussion about testosterone parameters, but if clinical symptoms are consistent with LOH and the testosterone level is < 8 nmol/l, hypogonadism is evidently indicated...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29303051/a-novel-function-of-geranylgeraniol-in-regulating-testosterone-production
#17
Hsin-Jung Ho, Hitoshi Shirakawa, Puspo E Giriwono, Asagi Ito, Michio Komai
Isoprenoids play widely differing roles in various physiological processes in animals and plants. Geranylgeraniol (GGOH) is an isoprenoid found in plants, and is an important metabolic derivative in the isoprenoid/cholesterol synthesis pathway. Earlier studies focused on GGOH's ability to improve the side effects of bisphosphonate therapy by regulating the mevalonate pathway. More recently, the mevalonate pathway-independent effects of GGOH have been described, including anti-inflammatory, anti-tumorigenic, and neuroprotective activities...
January 5, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29105668/-testosterone-replacement-therapy-and-cardiovascular-risk
#18
Giovanni Corona, Mauro Dicuio, Giulia Rastrelli, Alessandra Sforza, Mario Maggi
Late onset hypogonadism (LOH) is the most commonly used term to indicate the age-dependent reduction of testosterone. Sexual dysfunction represents the most important determinant for medical consultation and the most specific symptoms associated with LOH. In particular, data from the European Male Ageing Study (EMAS), a population-based survey on more than 3400 subjects, recognized that a triad of sexual symptoms (low libido and reduced spontaneous and sex-related erections) is the only syndromic association with decreased testosterone levels...
November 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29075365/antioxidant-and-antifibrotic-effect-of-a-herbal-formulation-in-vitro-and-in-the-experimental-andropause-via-nrf2-ho-1-signaling-pathway
#19
Woong Jin Bae, Guan Qun Zhu, Sae Woong Choi, Hyun Cheol Jeong, Fahad Bashraheel, Kang Sup Kim, Su Jin Kim, Hyuk Jin Cho, U Syn Ha, Sung Hoo Hong, Ji Youl Lee, Hyun-A Oh, Hye Cheong Koo, Do Ram Kim, Sung Yeoun Hwang, Sae Woong Kim
The Korean herbal formulation Ojayeonjonghwan is used for improving late-onset hypogonadism (LOH) symptoms such as erectile dysfunction (ED). A previous research suggested that a modified Ojayeonjonghwan (KH-204) could be used as an alternative to the treatment for ED. The pharmacological effects were examined in different conditions, including in vitro and in vivo. We measured the survival rate of TM3 Leydig cells under the oxidative stress condition. The s.c. injection of leuprorelin was used to induce androgen deprivation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28980739/serum-testosterone-levels-in-male-hypogonadism-why-and-when-to-check-a-review
#20
REVIEW
Mark Livingston, Anura Kalansooriya, Andrew J Hartland, Sudarshan Ramachandran, Adrian Heald
AIM: Although "late onset hypogonadism", a condition that includes low testosterone and symptoms, is common in men over the age of 40 years, diagnosis is not clear cut amongst non-specialists. It is the aim of this review to provide an up to date picture of how this state should be diagnosed and managed. METHODS: We aim to describe how primary and secondary hypogonadism should be excluded before the diagnosis of late onset hypogonadism is reached. As laboratory testosterone measurements are essential the current pitfalls such as inappropriate sample collection and the use of population derived reference ranges are expanded...
November 2017: International Journal of Clinical Practice
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