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https://www.readbyqxmd.com/read/28319300/children-s-mouthing-of-soil-contaminated-objects-is-associated-with-environmental-enteropathy
#1
Tomohiko Morita, Jamie Perin, Lauren Oldja, Shwapon Biswas, R Bradley Sack, Shahnawaz Ahmed, Rashidul Haque, Nurul Amin Bhuiyan, Tahmina Parvin, Sazzadul Islam Bhuyian, Mahmuda Akter, Kaisar A Talukder, Shahnaij Mohammad, Abu G Faruque, Christine Marie George
OBJECTIVE: To investigate the relationship between children's mouthing behaviors, diarrhea, and environmental enteropathy. METHODS: Prospective cohort study of 216 children ≤ 30 months of age in rural Bangladesh. Mouthing contacts with soil and food and objects with visible soil was measured by five-hour structured observation. Stool was analyzed for four fecal markers of intestinal inflammation: alpha-1-antitrypsin, myeloperoxidase, neopterin, and calprotectin...
March 20, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28318808/t-cell-receptor-assessment-in-autoimmune-disease-requires-access-to-the-most-adjacent-immunologically-active-organ
#2
Bergithe E Oftedal, Brita Ardesjö Lundgren, David Hamm, Poh-Yi Gan, Stephen R Holdsworth, Christopher N Hahn, Andreas W Schreiber, Hamish S Scott
Next generation sequencing of T and B cell receptors is emerging as a valuable and effective method to diagnose and monitor hematopoietic malignancies. So far, this approach has not been fully explored in regard to autoimmune diseases. T cells develop in the thymus where they undergo positive and negative selection, and the autoimmune regulator (Aire) is central in the establishment of immunological tolerance. Loss of Aire leads to severe multiorgan autoimmune disease with infiltration of autoreactive T cells in affected organs...
March 15, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28318752/cystathionine-gamma-lyase-deficient-mice-are-protected-against-the-development-of-multiorgan-failure-and-exhibit-reduced-inflammatory-response-during-burn
#3
Akbar Ahmad, Nadiya Druzhyna, Csaba Szabo
Considering the role of H2S in critical illness, the aim of this study was to compare the outcome of burn in wild-type mice and in mice deficient in CSE, one of the principal mammalian H2S-generating enzymes. Animals were subjected to scald burn. Outcome variables included indices of organ injury, clinical chemistry parameters and plasma levels of inflammatory mediators. Plasma levels of H2S significantly increased in response to burn in wild-type mice, but remained unchanged in CSE(-/-) mice. Expression of the three H2S-producing enzymes (CSE, CBS and 3-MST) in the lung and liver, and the capacity of tissue homogenates to produce H2S, however, was not affected by burn...
March 15, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28315999/artesunate-protects-lps-induced-acute-lung-injury-by-inhibiting-tlr4-expression-and-inducing-nrf2-activation
#4
Deli Zhao, Jinling Zhang, Guangquan Xu, Qiushi Wang
Artesunate, a derivative of artemisinin, has been reported to have anti-inflammatory property. However, few studies showed the protective effects of artesunate on lung injury. In this study, we aimed to investigate the effects of artesunate on LPS-induced lung injury in mice. The mice were treated with artesunate 1 h before or after LPS treatment. The effects of artesunate on lung MPO activity and malondialdehyde (MDA) content were detected. The lung wet/dry radio and the numbers of inflammatory cells in BALF were also measured...
March 18, 2017: Inflammation
https://www.readbyqxmd.com/read/28315822/protective-effect-of-zerumbone-reduces-lipopolysaccharide-induced-acute-lung-injury-via-antioxidative-enzymes-and-nrf2-ho-1-pathway
#5
Wai-Shing Leung, Ming-Ling Yang, Shiuan-Shinn Lee, Chi-Wen Kuo, Yung-Chyuan Ho, Rosa Huang-Liu, Hui-Wen Lin, Yu-Hsiang Kuan
Acute lung injury (ALI) is a serious disease with high morbidity and mortality rate. Although there are effective strategies for treatment of ALI; a widely accepted specific pharmacotherapy has not yet established. Zerumbone, the major active phytochemical compound from Zingiber zerumbet Smith, exhibits various beneficial biological and pharmacological activities, such as antioxidation, anti-inflammation, immunomodulation, and anti-cancer. We aimed to study the potential protective effects and mechanisms of zerumbone in mouse model of lipopolysaccharide (LPS)-induced ALI...
March 15, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28314627/n-%C3%AE%C2%B5-carboxymethyl-lysine-concentration-in-debris-from-carotid-artery-stenting-correlates-independently-with-signal-intensity-on-t1-weighted-black-blood-magnetic-resonance-images
#6
Ayumu Eto, Noriyuki Sakata, Ryoji Nagai, Jun-Ichi Shirakawa, Ritsurou Inoue, Fumiaki Kiyomi, Kouhei Nii, Hiroshi Aikawa, Minoru Iko, Masanori Tsutsumi, Kimiya Sakamoto, Fumihiro Hiraoka, Takahumi Mitsutake, Hayatsura Hanada, Kiyoshi Kazekawa
BACKGROUND AND PURPOSE: Because magnetic resonance imaging (MRI) focuses on the morphological characteristics of carotid artery plaques, its diagnostic value with respect to plaque vulnerability is limited. We examined the correlation between N(ε)-(carboxymethyl)lysine (CML), a main chemical structure of advanced glycation end-products, and the vulnerability of plaques visualized on MRI scans. MATERIALS AND METHODS: We enrolled 43 patients who had undergone carotid artery stenting (CAS) for carotid artery stenosis; all underwent MRI studies, including black-blood MRI and diffusion-weighted imaging (DWI)...
March 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28303417/protective-effect-of-amygdalin-on-lps-induced-acute-lung-injury-by-inhibiting-nf-%C3%AE%C2%BAb-and-nlrp3-signaling-pathways
#7
Ao Zhang, Weiyun Pan, Juan Lv, Hui Wu
The acute lung injury (ALI) is a leading cause of morbidity and mortality in critically ill patients. Amygdalin is derived from the bitter apricot kernel, an efficacious Chinese herbal medicine. Although amygdalin is used by many cancer patients as an antitumor agent, there is no report about the effect of amygdalin on acute lung injury. Here we explored the protective effect of amygdalin on ALI using lipopolysaccharide (LPS)-induced murine model by detecting the lung wet/dry ratio, the myeloperoxidase (MPO) in lung tissues, inflammatory cells in the bronchoalveolar lavage fluid (BALF), inflammatory cytokines production, as well as NLRP3 and NF-κB signaling pathways...
March 16, 2017: Inflammation
https://www.readbyqxmd.com/read/28302578/effects-of-carbon-sources-and-plant-protein-levels-in-a-biofloc-system-on-growth-performance-and-the-immune-and-antioxidant-status-of-nile-tilapia-oreochromis-niloticus
#8
Abdallah Tageldien Mansour, Maria Ángeles Esteban
The efficacy of different biofloc treatments (BFTs) to compensate for a reduction in dietary protein level under zero-water exchange systems was studied during a 10 weeks experiment, assessing the effect on water quality, growth, immune and antioxidant status of Nile tilapia (Oreochromis niloticus) fingerlings. Six groups were established and fed the same plant-based feed containing 20 or 30% crude protein: two groups in clear water conditions with no added carbon source, two biofloc groups given a wheat milling by-product (WMB) as additional carbon source and two biofloc groups given rice bran (RB)...
March 14, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28300927/histiocytoid-sweet-s-syndrome-presenting-with-annular-erythematous-plaques
#9
Renata Marcarini, Raquel Nardelli de Araujo, Monisa Martins Nóbrega, Karina Bittencourt Medeiros, Alexandre Carlos Gripp, Juan Manuel Piñeiro Maceira
Histiocytoid Sweet's Syndrome is a rare inflammatory disease described in 2005 as a variant of the classical Sweet's Syndrome (SS). Histopathologically, the dermal inflammatory infiltrate is composed mainly of mononuclear cells that have a histiocytic appearance and represent immature myeloid cells. We describe a case of Histiocytoid Sweet's Syndrome in an 18-year-old man. Although this patient had clinical manifestations compatible with SS, the cutaneous lesions consisted of erythematous annular plaques, which are not typical for this entity and have not been described in histiocytic form so far...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28300788/protective-effect-of-protocatechuic-acid-on-tnbs-induced-colitis-in-mice-is-associated-with-modulation-of-the-sphk-s1p-signaling-pathway
#10
Irene Crespo, Beatriz San-Miguel, José Luis Mauriz, Juan José Ortiz de Urbina, Mar Almar, María Jesús Tuñón, Javier González-Gallego
(1) Background: The present study aimed to investigate whether beneficial effects of protocatechuic acid (PCA) are associated with inhibition of the SphK/S1P axis and related signaling pathways in a 2,4,6-trinitrobenzenesulfonic acid (TNBS) model of inflammatory bowel disease; (2) Methods: Colitis was induced in male Balb/c mice by intracolonic administration of 2 mg of TNBS. PCA (30 or 60 mg/kg body wt) was given intraperitoneally daily for five days; (3) Results: Administration of PCA prevented the macroscopic and microscopic damage to the colonic mucosa, the decrease in body weight gain and the increase in myeloperoxidase activity induced by TNBS...
March 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28298306/il-1%C3%AE-induces-nf-%C3%AE%C2%BAb-and-upregulates-microrna-372-to-inhibit-spinal-cord-injury-recovery
#11
Wei Zhou, Tongzhou Yuan, Youshui Gao, Peipei Yin, Wei Liu, Chenhao Pan, Yingjie Liu, Xiaowei Yu
Excessive inflammation including IL-1β-initiated signaling is among the earlies reactions that can cause neuronal damage following spinal cord injury (SCI). It has been suggested that microRNAs may participate in stem cell repair to facilitate functional recovery after SCI. Here we showed that in cultured human neural stem cells (hNSC) IL-1β reduced the expressions of both KIF3B (kinesin family member 3B) and NOSIP (nitric oxide synthase interacting protein), two key modulators for restricting inflammation and promoting neuronal regeneration...
March 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28296991/clinicopathologic-immunohistochemical-and-molecular-features-of-histiocytoid-sweet-syndrome
#12
Victoria Alegría-Landa, Socorro María Rodríguez-Pinilla, Angel Santos-Briz, José Luis Rodríguez-Peralto, Victor Alegre, Lorenzo Cerroni, Heinz Kutzner, Luis Requena
Importance: Histiocytoid Sweet syndrome is a rare histopathologic variant of Sweet syndrome. The nature of the histiocytoid infiltrate has generated considerable controversy in the literature. Objective: The main goal of this study was to conduct a comprehensive overview of the immunohistochemical phenotype of the infiltrate in histiocytoid Sweet syndrome. We also analyze whether this variant of Sweet syndrome is more frequently associated with hematologic malignancies than classic Sweet syndrome...
March 15, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28296285/elevated-seminal-plasma-myeloperoxidase-is-associated-with-a-decreased-sperm-concentration-in-young-men
#13
J M Pullar, A C Carr, S M Bozonet, P Rosengrave, A J Kettle, M C M Vissers
Myeloperoxidase is a major neutrophil protein which generates oxidants that are highly reactive, and if present in seminal fluid, could be potentially damaging to spermatozoa. We recruited young males aged 18-35 years, unscreened for fertility status, for a pilot study measuring seminal plasma myeloperoxidase. On three occasions, over a 3-month period, we measured parameters of semen quality and correlated these with seminal myeloperoxidase protein and activity. After baseline measurement, participants were supplemented daily with 250 mg of vitamin C, a potent scavenger of reactive oxygen species with antiinflammatory activities...
March 10, 2017: Andrology
https://www.readbyqxmd.com/read/28295446/a-recombinant-cystatin-from-ascaris-lumbricoides-attenuates-inflammation-of-dss-induced-colitis
#14
Sandra Coronado, Luis Barrios, Josefina Zakzuk, Ronald Regino, Velky Ahumada, Luis Franco, Yanet Ocampo, Luis Caraballo
Helminthiasis may ameliorate inflammatory diseases, such as inflammatory bowel disease and asthma. Information about immunomodulators from Ascaris lumbricoides is scarce, but could be important considering the co-evolutionary relationships between helminths and humans. We evaluated the immunomodulatory effects of a recombinant cystatin from A. lumbricoides on an acute model of Dextran Sodium Sulphate (DSS)-induced colitis in mice. From an A. lumbricoides cDNA library we obtained a recombinant cystatin (rAl-CPI)...
March 10, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28293424/application-of-penalized-linear-regression-methods-to-the-selection-of-environmental-enteropathy-biomarkers
#15
Miao Lu, Jianhui Zhou, Caitlin Naylor, Beth D Kirkpatrick, Rashidul Haque, William A Petri, Jennie Z Ma
BACKGROUND: Environmental Enteropathy (EE) is a subclinical condition caused by constant fecal-oral contamination and resulting in blunting of intestinal villi and intestinal inflammation. Of primary interest in the clinical research is to evaluate the association between non-invasive EE biomarkers and malnutrition in a cohort of Bangladeshi children. The challenges are that the number of biomarkers/covariates is relatively large, and some of them are highly correlated. METHODS: Many variable selection methods are available in the literature, but which are most appropriate for EE biomarker selection remains unclear...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28293084/hydrogen-rich-water-protects-against-in%C3%AF-ammatory-bowel-disease-in-mice-by-inhibiting-endoplasmic-reticulum-stress-and-promoting-heme-oxygenase-1-expression
#16
Nai-Ying Shen, Jian-Bin Bi, Jing-Yao Zhang, Si-Min Zhang, Jing-Xian Gu, Kai Qu, Chang Liu
AIM: To investigate the therapeutic effect of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) and to explore the potential mechanisms involved. METHODS: Male mice were randomly divided into the following four groups: control group, in which the mice received equivalent volumes of normal saline (NS) intraperitoneally (ip); dextran sulfate sodium (DSS) group, in which the mice received NS ip (5 mL/kg body weight, twice per day at 8 am and 5 pm) for 7 consecutive days after IBD modeling; DSS + HRW group, in which the mice received HRW (in the same volume as the NS treatment) for 7 consecutive days after IBD modeling; and DSS + HRW + ZnPP group, in which the mice received HRW (in the same volume as the NS treatment) and ZnPP [a heme oxygenase-1 (HO-1) inhibitor, 25 mg/kg] for 7 consecutive days after IBD modeling...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28293082/anti-inflammatory-intestinal-activity-of-combretum-duarteanum-cambess-in-trinitrobenzene-sulfonic-acid-colitis-model
#17
Gedson Rodrigues de Morais Lima, Flavia Danniele Frota Machado, Larissa Lucena Périco, Felipe Meira de Faria, Anderson Luiz-Ferreira, Alba Regina Monteiro Souza Brito, Cláudia Helena Pellizzon, Clélia Akiko Hiruma-Lima, Josean Fechine Tavares, José Maria Barbosa Filho, Leônia Maria Batista
AIM: To evaluate the anti-inflammatory intestinal effect of the ethanolic extract (EtOHE) and hexane phase (HexP) obtained from the leaves of Combretum duarteanum (Cd). METHODS: Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated. RESULTS: Both Cd-EtOHE and Cd-HexP caused significant reductions in macroscopic lesion scores and ulcerative lesion areas...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28292014/ameliorative-effect-of-chromium-d-phenylalanine-complex-on-indomethacin-induced-inflammatory-bowel-disease-in-rats
#18
S Nagarjun, Shivsharan B Dhadde, Veeresh P Veerapur, B S Thippeswamy, Baburao N Chandakavathe
Present study was designed to evaluate the effect of chromium-d-phenylalanine complex (Cr (d-phe)3) on indomethacin-induced inflammatory bowel disease (IBD) in rats. Adult Wistar rats were pretreated with vehicle/Cr (d-phe)3 (30, 60 and 90μg/kg, p.o.) for 11days. On day 8 and 9, after one h of the above mentioned treatment, indomethacin (7.5mg/kg/day,s.c.) was administered to induce IBD. On day 12, blood samples were collected from animals for lactate dehydrogenase (LDH) estimation and ileum was isolated for macroscopic scoring, biochemical estimation (lipid peroxidation, reduced glutathione and myeloperoxidase activity) and histopathological study...
March 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28291538/-pyoderma-gangrenosum-associated-with-anti-proteinase-3%C3%A2-antineutrophil-cytoplasmic-antibodies-pr3-anca-induced-by-propylthiouracil
#19
A Coster, J-L Dargent, N de Visscher, P Levecque, P-P Roquet-Gravy
BACKGROUND: Synthetic antithyroid drugs are often used in the treatment of hyperthyroidism, regardless of aetiology. They may cause various side effects, including the development of anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis, and neutrophilic dermatoses. Propylthiouracil (PTU) is the antithyroid drug most frequently implicated in ANCA-associated diseases specifically involving anti-myeloperoxidase ANCA (MPO-ANCA). To our knowledge, there are no clinical reports describing the association of pyoderma gangrenosum (PG) and anti-proteinase3-ANCA (PR3-ANCA) induced by PTU, with ANCA levels decreasing after antithyroid drug withdrawal...
March 10, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28289922/curcumin-inhibits-lipopolysaccharide-lps-induced-endotoxemia-and-airway-inflammation-through-modulation-of-sequential-release-of-inflammatory-mediators-tnf-%C3%AE-and-tgf-%C3%AE-1-in-murine-model
#20
Asha Kumari, D Dash, Rashmi Singh
OBJECTIVE: Curcumin (diferuloylmethane), a major component of turmeric is well known for its anti-inflammatory potential. Present study investigates sequential release of inflammatory mediators post LPS challenge (10 mg/kg,i.p.) causing lung inflammation and its modulation by curcumin through different routes (20 mg/kg, i.p and 10 mg/kg, i.n.) in murine model. Dexamethasone (1 mg/kg, i.p) was used as standard drug. METHODS: Lung Inflammation was evaluated by histopathological analysis, myeloperoxidase (MPO) activity followed by inflammatory cell count and total protein content measurements in bronchoalveolar fluid (BALF)...
March 13, 2017: Inflammopharmacology
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