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https://www.readbyqxmd.com/read/29738769/neutrophils-infiltrating-pancreatic-ductal-adenocarcinoma-indicate-higher-malignancy-and-worse-prognosis
#1
Yufu Wang, Tianyi Fang, Lining Huang, Hao Wang, Lei Zhang, Zhidong Wang, Yunfu Cui
CD177 is considered to represent neutrophils. We analyzed mRNA expression level of CD177 and clinical follow-up survey of PDAC to estimate overall survival (OS) from Gene Expression Omnibus (GEO) dataset (GSE21501, containing samples from 102 PDAC patients) by R2 platform (http://r2.amc.nl). We also analyzed correlated genes of CD177 by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis to predict the potential relationship between neutrophils and prognosis of PDAC. We then performed hematoxylin and eosin (H&E) staining and immunohistochemical staining of surgical specimens to verify infiltration of neutrophils in PDAC tissues...
May 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29681787/the-response-to-neoadjuvant-chemoradiotherapy-with-5-fluorouracil-in-locally-advanced-rectal-cancer-patients-a-predictive-proteomic-signature
#2
Anaïs Chauvin, Chang-Shu Wang, Sameh Geha, Perrine Garde-Granger, Alex-Ane Mathieu, Vincent Lacasse, François-Michel Boisvert
Background: Colorectal cancer is the third most common and the fourth most lethal cancer in the world. In the majority of cases, patients are diagnosed at an advanced stage or even metastatic, thus explaining the high mortality. The standard treatment for patients with locally advanced non-metastatic rectal cancer is neoadjuvant radio-chemotherapy (NRCT) with 5-fluorouracil (5-FU) followed by surgery, but the resistance rate to this treatment remains high with approximately 30% of non-responders...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/29672788/neutrophil-extracellular-traps-participate-in-all-different-types-of-thrombotic-and-haemorrhagic-complications-of-coronary-atherosclerosis
#3
Kartika R Pertiwi, Allard C van der Wal, Dara R Pabittei, Claire Mackaaij, Marinus B van Leeuwen, Xiaofei Li, Onno J de Boer
Acute coronary syndromes can be initiated by either atherosclerotic fibrous cap ruptures, superficial plaque erosions or intraplaque haemorrhages (IPHs). Since neutrophil extracellular traps (NETs) display pro-inflammatory and pro-thrombotic properties, we investigated the presence, extent and distribution of neutrophils and NETs in different types of plaque complications in relation to the age of overlying thrombus mass or haemorrhage. Sixty-four paraffin-embedded coronary plaque segments of 30 acute myocardial infarction patients were retrieved from the autopsy archives, which contained 44 complicated plaques (17 IPHs, 9 erosions and 18 ruptures) and 20 intact plaques...
April 19, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29651938/semen-proteomics-reveals-the-impact-of-enterococcus-faecalis-on-male-fertility
#4
Giuseppe Grande, Federica Vincenzoni, Francesca Mancini, Silvia Baroni, Giovanni Luca, Riccardo Calafiore, Riccardo Marana, Massimo Castagnola, Alfredo Pontecorvi, Domenico Milardi
Infectious etiologies contribute to 15% of male factor infertility. Enterococcus faecalis is commonly identified in semen colture of infertile men and it is associated with significantly poorer semen quality. Aim of this study was to identify new seminal biomarkers for the male tract infection by E. faecalis, using proteomic profiling, in order to understand the effect of E. faecalis on the physiopathology of male reproduction. We included in the study ten patients seeking medical care for primary infertility with prostate-vescicular-epidydimitis and with microbiological analysis on semen and/or prostatic secretions positive for Enterococcus faecalis...
April 12, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29611387/flow-cytometric-analysis-of-hna-2-expression-and-phenotypes-among-thai-blood-donors
#5
Oytip Nathalang, Kanokpol Siriphanthong, Sawang Petvises, Nichapa Jeumjanya
BACKGROUND: Antibodies specific to human neutrophil antigen (HNA), especially HNA-2, are implicated in various conditions, including neonatal alloimmune neutropenia, febrile non-hemolytic transfusion reactions, and transfusion-related acute lung injury. The distribution of the HNA-2 phenotype frequencies in the Thai population remains unknown. This study aimed to investigate HNA-2 phenotype frequencies in Thai blood donors and to compare the relationships of sex and age with HNA-2 expression...
July 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29373091/validating-baboon-ex-vivo-and-in-vivo-radiation-related-gene-expression-with-corresponding-human-data
#6
M Port, M Majewski, F Herodin, M Valente, M Drouet, F Forcheron, A Tichy, I Sirak, A Zavrelova, A Malkova, B V Becker, D A Veit, S Waldeck, C Badie, G O'Brien, H Christiansen, J Wichmann, M Eder, G Beutel, J Vachelova, S Doucha-Senf, M Abend
The research for high-throughput diagnostic tests for victims of radio/nuclear incidents remains ongoing. In this context, we have previously identified candidate genes that predict risk of late-occurring hematologic acute radiation syndrome (HARS) in a baboon model. The goal of the current study was to validate these genes after radiation exposure in humans. We also examined ex vivo relative to in vivo measurements in both species and describe dose-response relationships. Eighteen baboons were irradiated in vivo to simulate different patterns of partial- or total-body irradiation (TBI), corresponding to an equivalent dose of 2...
April 2018: Radiation Research
https://www.readbyqxmd.com/read/29307001/three-dimensional-cellular-arrangement-in-epithelial-ovarian-cancer-cell-lines-tov-21g-and-skov-3-is-associated-with-apoptosis-related-mirna-expression-modulation
#7
Aline Brito de Lima, Luciana Maria Silva, Nikole Gontijo Gonçales, Maria Raquel Santos Carvalho, Agnaldo Lopes da Silva Filho, Letícia da Conceição Braga
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, and the lack of chemoresistance biomarkers contributes to the poor prognosis. Cancer stem cells (CSC) have been investigated in EOC to understand its relationship with chemoresistance and recurrence. In this context, in vitro cultivation-models are important tools for CSC studies. MicroRNAs (miRNAs) play key roles in cancer, CSC regulation and apoptosis. Thus, this study aims to evaluate the tumorsphere model as CSC-enrichment method in EOC studies and investigate apoptosis-related miRNAs in tumorspheres-derived EOC cell lines...
January 6, 2018: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/29228136/cd177-neutrophils-suppress-epithelial-cell-tumourigenesis-in-colitis-associated-cancer-and-predict-good-prognosis-in-colorectal-cancer
#8
Guangxi Zhou, Kangsheng Peng, Yang Song, Wenjing Yang, Weigang Shu, Tianming Yu, Lin Yu, Moubin Lin, Qing Wei, Chunqiu Chen, Lu Yin, Yingzi Cong, Zhanju Liu
Neutrophils are found to be infiltrated in tumour tissues of patients with colitis-associated cancer (CAC) and colorectal cancer (CRC), and CD177 is mainly expressed in neutrophils. In our study, expression of CD177 in tumour tissues from patients with CAC or CRC was analysed byquantitative real-time polymerase chain reaction, flow cytometry and immunohistochemistry. We recruited 378 patients with CRC, determined CD177 expression in tumours and examined its correlation with clinicopathological features. Moreover, CAC model was induced in wild-type and CD177-/- mice by azoxymethane/dextran sodium sulphate...
February 9, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/28984903/whole-genome-microarray-expression-analysis-in-blood-identifies-pathways-linked-to-signs-and-symptoms-of-a-patient-with-hypercalprotectinaemia-and-hyperzincaemia
#9
H S Isaksson, S A Farkas, P Müller, D Gustafsson, T K Nilsson
A child, 2 years with the 'hypercalprotectinaemia with hyperzincaemia' clinical syndrome, presented with atypical symptoms and signs, notably persistent fever of approximately 38°C, thrombocythaemia of > 700 × 109 /l and a predominance of persistent intestinal symptoms. In an effort to find a cure by identifying the dysregulated pathways we analysed whole-genome mRNA expression by the Affymetrix HG U133 Plus 2·0 array in blood on three occasions 3-5 months apart. Major up-regulation was demonstrated for the Janus kinase/signal transducer and activators of transcription (JAK/STAT) pathway including, in particular, CD177, S100A8, S100A9 and S100A12, accounting for the thrombocytosis; a large number of interleukins, their receptors and activators, accounting for the febrile apathic state; and the high mobility group box 1 (HMBG1) gene, possibly accounting for part of the intestinal symptoms...
February 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28981629/usefulness-of-transcriptional-blood-biomarkers-as-a-non-invasive-surrogate-marker-of-mucosal-healing-and-endoscopic-response-in-ulcerative-colitis
#10
Núria Planell, M Carme Masamunt, Raquel Franco Leal, Lorena Rodríguez, Miriam Esteller, Juan J Lozano, Anna Ramírez, Maria de Lourdes Setsuko Ayrizono, Claudio Saddy Rodrigues Coy, Ignacio Alfaro, Ingrid Ordás, Sudha Visvanathan, Elena Ricart, Jordi Guardiola, Julián Panés, Azucena Salas
Background and Aims: Ulcerative colitis [UC] is a chronic inflammatory disease of the colon. Colonoscopy remains the gold standard for evaluating disease activity, as clinical symptoms are not sufficiently accurate. The aim of this study is to identify new accurate non-invasive biomarkers based on whole-blood transcriptomics that can predict mucosal lesions and response to treatment in UC patients. Methods: Whole-blood samples were collected for a total of 152 UC patients at endoscopy...
October 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28857501/potential-roles-of-neutrophils-in-regulating-intestinal-mucosal-inflammation-of-inflammatory-bowel-disease
#11
REVIEW
Guang Xi Zhou, Zhan Ju Liu
Inflammatory bowel diseases (IBD), comprising of ulcerative colitis and Crohn's disease, are inflammatory disorders of the gastrointestinal tract characterized by chronically relapsing mucosal inflammation. Neutrophils, as the effector cells of acute inflammation, have long been reported to play a role in the maintenance of intestinal homeostasis and pathogenesis of IBD. At the early stage of mucosal inflammation in patients with IBD, neutrophils flood into intestinal mucosa, phagocytose pathogenic microbes, and promote mucosal healing and resolution of inflammation...
September 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28825581/-gastrointestinal-stromal-tumor-and-renal-transplant
#12
Carina E Seculini Patiño, Aldo H Tabares, Maria V Laborie, Ana Diller
Gastrointestinal stromal tumor (GIST) accounts for nearly 1% of all gastrointestinal tumors. Its association with renal transplantation is not frequent. Approximately 95% of GIST show staining for CD177. DOG1 is a recently described monoclonal antibody that shows positivity even in the absence of CD177 staining. The diagnosis of GIST should be pursued because of the availability of very effective treatments with tyrosine-kinase inhibitors. Herein, we describe the case of a woman with renal transplant who presented a small bowel GIST and weak positivity for CD177, treated initially with surgery...
2017: Medicina
https://www.readbyqxmd.com/read/28807980/cd177-modulates-human-neutrophil-migration-through-activation-mediated-integrin-and-chemoreceptor-regulation
#13
Ming Bai, Ricardo Grieshaber-Bouyer, Junxia Wang, Angela B Schmider, Zachary S Wilson, Liling Zeng, Olha Halyabar, Matthew D Godin, Hung N Nguyen, Anaïs Levescot, Pierre Cunin, Craig T Lefort, Roy J Soberman, Peter A Nigrovic
CD177 is a glycosylphosphatidylinositol (GPI)-anchored protein expressed by a variable proportion of human neutrophils that mediates surface expression of the antineutrophil cytoplasmic antibody antigen proteinase 3. CD177 associates with β2 integrins and recognizes platelet endothelial cell adhesion molecule 1 (PECAM-1), suggesting a role in neutrophil migration. However, CD177pos neutrophils exhibit no clear migratory advantage in vivo, despite interruption of in vitro transendothelial migration by CD177 ligation...
November 9, 2017: Blood
https://www.readbyqxmd.com/read/28777750/polymorphonuclear-neutrophil-functions-are-differentially-altered-in-amnestic-mild-cognitive-impairment-and-mild-alzheimer-s-disease-patients
#14
Aurélie Le Page, Julie Lamoureux, Karine Bourgade, Eric H Frost, Graham Pawelec, Jacek M Witkowski, Anis Larbi, Gilles Dupuis, Tamàs Fülöp
The mechanisms of neurodegeneration in Alzheimer's disease (AD) remain under investigations. Alterations in the blood-brain barrier facilitate exchanges of inflammatory mediators and immune cells between the brain and the periphery in AD. Here, we report analysis of phenotype and functions of polymorphonuclear neutrophils (PMN) in peripheral blood in amnestic mild cognitive impairment (aMCI, n = 13), patients with mild AD (mAD, n = 15), and healthy elderly controls (n = 13). Results showed an increased expression of CD177 in mAD but not in healthy or aMCI patients...
July 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28661454/chlorogenic-acid-ameliorates-experimental-colitis-by-promoting-growth-of-akkermansia-in-mice
#15
Zhan Zhang, Xinyue Wu, Shuyuan Cao, Meghan Cromie, Yonghua Shen, Yiming Feng, Hui Yang, Lei Li
Chlorogenic acid (ChA)-one of the most abundant polyphenol compounds in the human diet-exerts anti-inflammatory activities. The aim of this study was to investigate the effect of ChA on gut microbiota in ulcerative colitis (UC). Colitis was induced by 2.5% dextran sulfate sodium (DSS) in C57BL/6 mice, which were on a control diet or diet with ChA (1 mM). The histopathological changes and inflammation were evaluated. Fecal samples were analyzed by 16S rRNA gene sequencing. ChA attenuated several effects of DSS-induced colitis, including weight loss, increased disease activity index, and improved mucosal damage...
June 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28559244/gene-silencing-and-a-novel-monoallelic-expression-pattern-in-distinct-cd177-neutrophil-subsets
#16
Claudia Eulenberg-Gustavus, Sylvia Bähring, Philipp G Maass, Friedrich C Luft, Ralph Kettritz
CD177 presents antigens in allo- and autoimmune diseases on the neutrophil surface. Individuals can be either CD177-deficient or harbor distinct CD177neg and CD177pos neutrophil subsets. We studied mechanisms controlling subset-restricted CD177 expression in bimodal individuals. CD177pos , but not CD177neg neutrophils, produced CD177 protein and mRNA. Haplotype analysis indicated a unique monoallelic CD177 expression pattern, where the offspring stably transcribed either the maternal or paternal allele. Hematopoietic stem cells expressed both CD177 alleles and silenced one copy during neutrophil differentiation...
July 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28521472/cd117-expression-is-a-predictive-marker-for-poor-prognosis-in-patients-with-non-small-cell-lung-cancer
#17
Tomohiko Sakabe, Junya Azumi, Tomohiro Haruki, Yoshihisa Umekita, Hiroshige Nakamura, Goshi Shiota
Non-small cell lung cancer (NSCLC) accounts for >85% of incidences of lung cancer, for which the predicted 5-year survival rates are low and recurrence rates remain high. Although it has been reported that the patients with SCLC cells that possess the cluster of differentiation (CD) 117 marker exhibited poor prognosis and poor response to chemotherapy, no studies concerning the association of CD117 expression with prognosis of the patients with NSCLC have been reported. An in vitro study reportedly revealed that CD117-positive cell populations in NSCLC cell lines exhibited cancer stem cell (CSC) phenotypes including self-renewal and chemoresistance...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28468761/cd177-neutrophils-as-functionally-activated-neutrophils-negatively-regulate-ibd
#18
Guangxi Zhou, Lin Yu, Leilei Fang, Wenjing Yang, Tianming Yu, Yinglei Miao, Minhu Chen, Kaichun Wu, Feidi Chen, Yingzi Cong, Zhanju Liu
BACKGROUND: Neutrophils are accumulated in inflamed mucosa of IBD and play an important role in the pathogenesis. CD177 is expressed in neutrophils specifically and upregulated during inflammation. However, the role of CD177(+) neutrophils in pathogenesis of IBD remains elusive. MATERIALS AND METHODS: Expression of CD177 was analysed in peripheral blood and intestinal mucosa from patients with IBD using quantitative RT-PCR, flow cytometry and immunohistochemistry...
May 3, 2017: Gut
https://www.readbyqxmd.com/read/28240246/characterization-of-the-cd177-interaction-with-the-anca-antigen-proteinase-3
#19
Uwe Jerke, Stephen F Marino, Oliver Daumke, Ralph Kettritz
Proteinase 3 is a serine protease found in neutrophil granules and on the extracellular neutrophil membrane (mPR3). mPR3 is a major antigen for anti-neutrophil cytoplasmic antibodies (PR3-ANCAs), autoantibodies causing fatal autoimmune diseases. In most individuals, a subpopulation of neutrophils also produce CD177, proposed to present additional PR3 on the surface, resulting in CD177(neg)/mPR3(low) and CD177(pos)/mPR3(high) neutrophil subsets. A positive correlation has been shown between mPR3 abundance, disease incidence, and clinical outcome...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229027/risk-analysis-of-colorectal-cancer-incidence-by-gene-expression-analysis
#20
Wei-Chuan Shangkuan, Hung-Che Lin, Yu-Tien Chang, Chen-En Jian, Hueng-Chuen Fan, Kang-Hua Chen, Ya-Fang Liu, Huan-Ming Hsu, Hsiu-Ling Chou, Chung-Tay Yao, Chi-Ming Chu, Sui-Lung Su, Chi-Wen Chang
BACKGROUND: Colorectal cancer (CRC) is one of the leading cancers worldwide. Several studies have performed microarray data analyses for cancer classification and prognostic analyses. Microarray assays also enable the identification of gene signatures for molecular characterization and treatment prediction. OBJECTIVE: Microarray gene expression data from the online Gene Expression Omnibus (GEO) database were used to to distinguish colorectal cancer from normal colon tissue samples...
2017: PeerJ
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