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J Ari, F Starecki, C Boussard-Plédel, Y Ledemi, Y Messaddeq, J-L Doualan, A Braud, B Bureau, V Nazabal
Rare earth ion doped materials are means to obtain cost-effective infrared light sources, with enough brilliance for applications such as gas sensing. Within a sulfide matrix, the simultaneous luminescence of both Pr3+ and Dy3+ in the Ga5 Ge20 Sb10 S65 glass is reported. The use of these two rare earths is giving rise to a broad continuous luminescence in the 2.2-5.5 µm wavelength range, which could be used as a mid-infrared light source for gas-sensing applications. The demonstration of CO2 and CH4 detection using a fiber drawn from these materials is reported...
June 15, 2018: Optics Letters
Yigit Ozan Aydın, Vincent Fortin, Darren Kraemer, Alex Fraser, Réal Vallée, Martin Bernier
We report the demonstration of a 2850 nm diode-pumped Ho3+ , Pr3+ co-doped fluoride fiber amplifier that delivers pulses with an average power of 2.45 W, 122 μJ energy, and 500 ps duration at a repetition rate of 20 kHz. To the best of our knowledge, the average power and pulse energy are the highest to be obtained from a sub-nanosecond fiber source operating in the 3 μm spectral region. The amplifier is seeded by an optical parametric generation source and is pumped around 915 nm using widely available InGaAs laser diodes...
June 15, 2018: Optics Letters
Bangaru Subban, Roobanguru Dhanraj
The luminescence properties of praseodymium (Pr3+ ) ion in potassium bromide (KBr) host have been investigated. The excitation bands observed in the region 220-300 nm are attributed to the transitions from 4f level to the 5d crystal field splitting levels of Pr3+ ion. Emission bands originated due to transition of 3 P2 →3 H6 (564 nm), 3 P0 →3 H6 (604 nm), 1 D2 →3 P4 (721 nm) and 3 P0 →3 F2 (659 nm) have been observed. Optical absorption, photoluminescence (PL) and thermoluminescence (TL) studies confirms the trivalent state of Pr3+ ion in KBr host...
June 13, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
Erika Marroquín-Fabián, Natllely Ruiz, Jorge Mena-Zúñiga, Luis Felipe Flores-Suárez
OBJECTIVES: Granulomatosis with polyangiitis-a primary systemic vasculitis-most frequent manifestations are respiratory. Airway disease can present with stenosis, and although subglottic stenosis (SGS) is well described, narrowing distal to the glottis has been more recently the focus of reporting. Our objectives, therefore, are to describe the frequency, characteristics, and treatment of tracheobronchial stenoses (TBS) in granulomatosis with polyangiitis (GPA) at our institution, a national referral center for respiratory diseases...
May 16, 2018: Seminars in Arthritis and Rheumatism
Akito Hasegawa, Atsushi Fujimoto, Daisuke Yuki, Ryota Hayashi, Atsuko Aizawa, Takako Ito, Riichiro Abe
No abstract text is available yet for this article.
June 8, 2018: European Journal of Dermatology: EJD
Dong-Yuan Chang, Zhi-Ying Li, Min Chen, Ming-Hui Zhao
OBJECTIVE: Antineutrophil cytoplasmic antibody (ANCA) directed to proteinase 3 (PR3) used to be considered the serologic marker for granulomatosis with polyangiitis (GPA). However, patients with myeloperoxidase (MPO)-ANCA positive GPA have been increasingly reported. The aim of this study was to analyze the clinical and pathological characteristics and outcome of Chinese patients with MPO-ANCA positive GPA. METHODS: The clinical and renal histology data, renal outcomes, response to treatment, relapse and mortality were compared between patients with MPO-ANCA positive GPA and MPO-ANCA positive microscopic polyangiitis (MPA) as well as proteinase 3 (PR3)-ANCA positive GPA...
May 9, 2018: Seminars in Arthritis and Rheumatism
Haitham H Hassane, Mirza M Beg, Chokkalingam Siva, Celso Velázquez
BACKGROUND Systemic vasculitis can present with a multitude of symptoms involving multiple organ systems. Clinicians should avoid anchoring bias and be cognizant that different types of vasculitides can be present in the same patient and that the diagnosis of one should not preclude the subsequent diagnosis of another. CASE REPORT A 67-year-old woman was referred for evaluation of episodes of epistaxis and recurrent severe sinusitis. Her physical examination showed nasal congestion and purpuric rash on the lower extremities...
June 6, 2018: American Journal of Case Reports
Yun-Xia Qu, Kai-Zhi Zhou, Kai Chen, Yun-Qian Zhang, Xin Xiao, QingDi Zhou, Zhu Tao, Pei-Hua Ma, Gang Wei
Coordination and supramolecular assemblies of a fully substituted cyclopentanocucurbit[6]uril (CyP6 Q[6]) with a series of lanthanide cations (Ln3+ ) have been investigated in the presence of tetrachlorozincate anion ([ZnCl4 ]2- ). X-ray single-crystal diffraction analysis has revealed that the interaction of CyP6 Q[6] and a series of Ln3+ cations unexpectedly results in the formation of at least seven different CyP6 Q[6]-based coordination complex adduct and supramolecular assemblies groups, including with (1) La3+ , Ce3+ cations; (2) Pr3+ , Nd3+ cations; (3) Eu3+ , Gd3+ , Tb3+ , Dy3+ with P1̅ or P1 space group, in which CyP6 Q[6] molecules coordinate alternatively with Ln3+ cations and form linear coordination polymers; (4) CyP6 Q[6] molecules interact alternatively with [Ho(H2 O)8 ]3+ aqueous complexes and form linear supramolecular chains; CyP6 Q[6] molecules can assemble two different Ln3+ free porous supramolecular assemblies from CyP6 Q[6]-Ln(NO3 )3 -ZnCl2 -HCl systems, Ln = Tm, Yb, and Lu; however, no solid crystals were obtained from system containing Er3+ cation...
June 4, 2018: Inorganic Chemistry
Luca Rocchigiani, Julio Fernandez-Cestau, Isabelle Chambrier, Peter Hrobárik, Manfred Bochmann
The synthesis of new families of stable or at least spectroscopically observable gold(III) hydride complexes is reported, including anionic cis-hydrido chloride, hydrido aryl and cis-dihydride complexes. Reactions between (C^C)AuCl(PR3) and LiHBEt3 afford the first examples of gold(III) phosphino hydrides (C^C)AuH(PR3) (R = Me, Ph, p-tolyl; C^C = 4,4'-di-tert-butylbiphenyl-2,2'-diyl). The X-ray structure of (C^C)AuH(PMe3) was determined. LiHBEt3 reacts with (C^C)AuCl(py) to give [(C^C)Au(H)Cl] , whereas (C^C)AuH(PR3) undergoes phosphine displacement, generating the dihydride [(C^C)AuH2] ...
June 4, 2018: Journal of the American Chemical Society
Haruka Hirono, Kazuhiko Watanabe, Katsuhiko Hasegawa, Terasu Honma, Yoichi Ajioka, Shogo Ohkoshi
BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory bowel disease, affecting the colon continuously from the rectum proximally. However, a clinical type with right-sided colitis sparing the anal side of the colon is also known. Mesalamine, which is generally used to treat UC, can rarely aggravate the disease. CASE REPORT A 56-year-old woman with no history of colonic diseases visited our hospital because of a positive fecal occult blood test. The first colonoscopy showed inflamed and edematous mucosa extending from the ascending colon to the right-half of the transverse colon...
May 31, 2018: American Journal of Case Reports
Alex Waked, Rouzbeh Ostadsharif Memar, Douglas Wade Stephan
Reaction of PPh3 and [(p-ClC6H4)N2][BF4] affords [(p-ClC6H4)N(PPh3)N(PPh3)][BF4] 1, while reaction with (Ph2PCH2)2 gave [(p-ClC6H4)(NPh2PCH2)2)][BF4] 2. These species confirm the Lewis acidity of [(p-ClC6H4)N2(PR3)][BF4] cations at N. In contrast, use of bulky phosphines afford the species [ArN2(PR3)][BF4] (R = tBu 3, Mes 4). Compound 3 undergoes one electron reduction to give the stable radical [(p-ClC6H4)N2(PtBu3)]* 5. Combination of 3 and PtBu3 acts as an FLP to effect (SPh)2 cleavage, generating [PhSPtBu3]+ and the radical [ArN2(PR3)]*...
May 28, 2018: Angewandte Chemie
Jessica Götzfried, Natalia F Smirnova, Carmela Morrone, Brice Korkmaz, Ali Önder Yildirim, Oliver Eickelberg, Dieter E Jenne
BACKGROUND: Vascular damage and primary graft dysfunction increase with prolonged preservation times of transplanted donor lungs. Hence, storage and conservation of donated lungs in protein-free, dextran-containing electrolyte solutions, like Perfadex, is limited to about 6 hours. We hypothesized that transplanted lungs are protected against neutrophil-mediated proteolytic damage by adding α1 -anti-trypsin (AAT), a highly abundant human plasma proteinase inhibitor, to Perfadex. METHODS: A realistic clinically oriented murine model of lung transplantation was used to simulate the ischemia-reperfusion process...
March 30, 2018: Journal of Heart and Lung Transplantation
Tirta Rona Mayangsari, Jae-Min Park, Luchana Lamierza Yusup, Jiyeon Gu, Jin-Hyuk Yoo, Heon-Do Kim, Won-Jun Lee
We report the catalyzed atomic layer deposition (ALD) of silicon oxide using Si2 Cl6 , H2 O, and various alkylamines. The density functional theory (DFT) calculations using periodic slab model of the SiO2 surface were performed for the selection of alternative Lewis-base catalysts with high catalytic activities. During the first half-reaction, the catalysts with less steric hindrance such as pyridine would be more effective than bulky alkylamines despite lower nucleophilicity. On the other hand, during the second half-reaction, the catalysts with a high nucleophilicity such as triethylamine (Et3 N) would be more efficient because the steric hindrance is less critical...
May 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Pascale Tacnet-Delorme, Julie Gabillet, Simon Chatfield, Nathalie Thieblemont, Philippe Frachet, Véronique Witko-Sarsat
Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs). Moreover, PR3 is a serine protease whose membrane expression can potentiate inflammatory diseases such as ANCA-associated vasculitis and rheumatoid arthritis. During apoptosis, PR3 is co-externalized with phosphatidylserine (PS) and is known to modulate the clearance of apoptotic cells through a calreticulin (CRT)-dependent mechanism...
2018: Frontiers in Immunology
Panyi Liang, Atsushi Kobayashi, W M C Sameera, Masaki Yoshida, Masako Kato
Luminescent [Cu2 I2 (pyrpy)2 (PR3 )2 ] complexes (pyrpy = 4-pyrrolidinopyridine; PR3 = triphenylphosphine (1), tri- m-tolylphosphine (2), tri- p-tolylphosphine (3)) were prepared by solution reactions and a rarely reported solvent-free thermal method. X-ray structure analyses reveal that complexes composed of dinuclear {Cu2 I2 } cores surrounded by two PR3 and two pyrpy ligands were formed. Although the melting point of pyrpy is the lowest among the organic units used in this study, the temperature required to form the luminescent dinuclear complex, prepared by the thermal synthesis method, depended strongly on the PR3 moiety...
May 9, 2018: Inorganic Chemistry
Takehisa Yamada, Koji Mugishima, Seiichiro Higo, Yukie Yoshida, Fumiaki Itagaki, Shizuka Yui, Tetsuya Kashiwagi, Yoko Endo, Akira Shimizu, Shuichi Tsuruoka
We report here a case of systemic lupus erythematosus (SLE) with pulmonary hemorrhage and anti-glomerular basement membrane (anti-GBM) antibodies. A 42-year-old woman was admitted to our hospital with complaints of exanthema, arthralgia, shortness of breath, and hemoptysis. Plain chest computed tomography (CT) scan revealed pericardial effusion, bilateral pleural effusions, and pulmonary hemorrhage. Laboratory findings on admission revealed proteinuria, microscopic hematuria, anemia, leukopenia, hypoalbuminemia, hypocomplementemia, and slightly elevated levels of serum creatinine...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Maria Weiner, Rune Bjørneklett, Zdenka Hrušková, Bruce Mackinnon, Caroline J Poulton, Leo Sindelar, Aladdin J Mohammad, Per Eriksson, Loreto Gesualdo, Duvuru Geetha, Matija Crnogorac, David Jayne, Susan L Hogan, Colin Geddes, Vladimir Tesar, Knut Aasarød, Mårten Segelmark
Background: In anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, antigen specificity varies between myeloperoxidase (MPO) and proteinase 3 (PR3). This has been reported to vary in relation to age, gender, geography and extrarenal manifestations. However, studies are difficult to compare as criteria for inclusion vary. The aim of this study was to investigate the relationship between ANCA serotype, latitude, ultraviolet (UV) radiation levels, age, gender and renal function at diagnosis in a large study with uniform inclusion criteria...
April 30, 2018: Nephrology, Dialysis, Transplantation
Joshua S Sapsford, Daniel J Scott, Nathan J Allcock, Matthew J Fuchter, Christopher J Tighe, Andrew E Ashley
Despite the ever-broadening applications of main-group 'frustrated Lewis pair' (FLP) chemistry to both new and established reactions, their typical intolerance of water, especially at elevated temperatures (>100 °C), represents a key barrier to their mainstream adoption. Herein we report that FLPs based on the Lewis acid i Pr3 SnOTf are moisture tolerant in the presence of moderately strong nitrogenous bases, even under high temperature regimes, allowing them to operate as simple and effective catalysts for the reductive amination of organic carbonyls, including for challenging bulky amine and carbonyl substrate partners...
March 20, 2018: Advanced Synthesis & Catalysis
Shen Ning, Xinhua Zhang, Cheng Xu, Xin Dang, Hao Cheng, Kejian Zhu, Yongmei Han
RATIONALE: The treatment of granulomatosis with polyangiitis (GPA) with life-threatening complications, such as diffuse alveolar hemorrhage (DAH) and gastrointestinal hemorrhage (GIH), remains challenging. PATIENT CONCERNS: A 70-year-old female presented with a 6-month history of a productive cough and a 10-day history of arthralgia that progressed to respiratory failure and massive hematochezia. DIAGNOSES: Chest high-resolution computed tomography (HRCT) revealed multiple nodules, masses, and cavities...
April 2018: Medicine (Baltimore)
Kotaro Matsumoto, Mitsuhiro Akiyama, Nobuhiko Kajio, Kotaro Otomo, Kazuko Suzuki, Naoshi Nishina, Kento Kasuya, Naoki Oishi, Kaori Kameyama, Tsutomu Takeuchi
RATIONALE: Hypertrophic pachymeningitis (HP) is an uncommon, life-threatening disease that is seen in elderly patients with antineutrophil cytoplasmic antibody (ANCA) positivity. Proteinase-3 (PR3)-ANCA-positive HP has not been reported in adolescents. Here, we report the first case of adolescent PR3-ANCA-positive HP successfully treated with immunosuppressive therapy. PATIENT CONCERNS: A 14-year-old female presented with fullness and pain in her right ear unresponsive to antibiotics...
April 2018: Medicine (Baltimore)
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