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https://www.readbyqxmd.com/read/28514287/concurrent-igg4-related-tubulointerstitial-nephritis-and-igg4-myeloperoxidase-anti-neutrophil-cytoplasmic-antibody-positive-crescentic-glomerulonephritis-a-case-report
#1
Tao Su, Li Yang, Zhao Cui, Su-Xia Wang, Ming-Hui Zhao
RATIONALE: IgG4-related disease (IgG4-RD) is a newly recognized systemic disease. The typical pathological finding in the kidney is abundant IgG4-positive plasma cell infiltration with characteristic storiform fibrosis in the interstitium. Antibodies of the IgG4 subclass have been linked to certain autoimmune diseases including antiproteinase 3 (PR3) anti-neutrophil cytoplasmic antibody (ANCA) of the IgG4 subclass. Here, we report a rare case of kidney injury with concurrent typical IgG4-related tubulointerstitial nephritis and IgG4 subclass of myeloperoxidase (MPO) ANCA-positive necrotizing crescentic glomerulonephritis...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28513131/improved-oxidase-mimetic-activity-by-praseodymium-incorporation-into-ceria-nanocubes
#2
Lei Jiang, Susana Fernandez-Garcia, Miguel Tinoco, Zhaoxia Yan, Qi Xue, Ginesa Blanco, José J Calvino, Ana Belen Hungría, Xiaowei Chen
In this study, ceria nanocubes (NC) modified with increasing concentrations of praseodymium (5, 10, 15 and 20mol.%) have been successfully synthesized by a hydrothermal method. The as-synthesized Pr-modified ceria nanocubes exhibit an enhanced oxidase-like activity on the organic dye TMB within a wide range of concentrations and durations. The oxidase activity increases with increasing Pr amounts in Pr-modified ceria nanocubes within the investigated concentration range. Meanwhile, these Pr-modified ceria nanocubes also show higher reducibility than pure ceria nanocubes...
May 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28509135/renal-limited-vasculitis-with-elevated-levels-of-multiple-antibodies
#3
Noriaki Sato, Hideki Yokoi, Hirotaka Imamaki, Eiichiro Uchino, Kaoru Sakai, Takeshi Matsubara, Tatsuo Tsukamoto, Sachiko Minamiguchi, Motoko Yanagita
Renal-limited vasculitis (RLV) is a type of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis that presents with crescentic glomerulonephritis with no other organ involvement. Although several studies reported patients with crescentic glomerulonephritis who were dual positive for proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA or ANCA and anti-glomerular basement membrane (GBM) antibody, patients positive for all three antibodies, i.e., triple-positive patients, were rarely reported. We herein report the case of a male with pauci-immune type crescentic glomerulonephritis positive for MPO-ANCA, PR3-ANCA, and anti-GBM antibody...
May 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28509125/a-case-of-pr3-anca-positive-anti-gbm-disease-associated-with-intrarenal-arteritis-and-thrombotic-microangiopathy
#4
Shun Manabe, Mayuko Banno, Marie Nakano, Teruhiro Fujii, Yukio Kakuta, Kosaku Nitta, Michiyasu Hatano
Coexistence of anti-glomerular basement membrane (anti-GBM) disease with anti-neutrophil cytoplasmic antibody (ANCA) is occasionally reported and termed "double positive" disease. Interestingly, the majority of "double positive" ANCA is myeloperoxidase (MPO)-ANCA, and some of the MPO-ANCA-positive cases reveal intrarenal arteritis indicating an ANCA-associated renal lesion. In contrast, proteinase 3 (PR3)-ANCA-positive "double positive" disease had rarely been reported, and as far as we know, none of the cases showed intrarenal arteritis...
May 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28495524/granulomatosis-with-polyangiitis-wegener-granulomatosis-a-proteinase-3-driven-disease
#5
Véronique Witko-Sarsat, Nathalie Thieblemont
Granulomatosis with polyangiitis (GPA, Wegener granulomatosis) is a systemic autoimmune vasculitis that affects small arteries, arterioles, and capillaries, most notably in the kidneys and lungs. In this disease, proteinase 3 (PR3), produced by neutrophils, is targeted by antineutrophil cytoplasmic antibodies (ANCA). Recent work by our group has shown how PR3 impairs the resolution of inflammation and deregulates the immune system. Normally, the clearance of activated neutrophils triggers an anti-inflammatory, pro-resolution process...
May 8, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28495147/discrepancies-between-two-immunoassays-for-the-determination-of-mpo-and-pr3-autoantibodies
#6
Qian Sun, Boris Calderon, Zhen Zhao
BACKGROUND: Testing for autoantibodies to myeloperoxidase (MPO) and proteinase 3 (PR3) is part of anti-neutrophil cytoplasmic antibodies (ANCA) test that aids the diagnosis of a number of autoimmune diseases including small-vessel vasculitis. We characterized the differences between two automated immunoassays at three facilities for measuring MPO- and PR3-ANCA autoantibodies. METHODS: 117 serum samples were analyzed for MPO and PR3 autoantibodies. The INOVA QUANTA Lite® IgG assay (INOVA Diagnostics) were performed at two facilities and the Bio-Plex® 2200 Vasculitis Panel (Bio-Rad) were performed at a third reference lab...
May 8, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28463502/unusual-reactions-of-nacnacal-with-urea-and-phosphine-oxides
#7
Terry Chu, Sergei F Vyboishchikov, Bulat M Gabidullin, Georgii I Nikonov
The reaction of cyclic urea 1,3-dimethyl-2-imidazolidinone with the aluminum(I) compound NacNacAl (1) gives an unexpected adduct of urea with the isomerized aluminum(III) hydride NacNac'AlH(O═SIMe) (3). A related reaction of 1 with phosphine oxides results in cleavage of the P═O bond and formation of hydroxyl derivatives NacNac'Al(OH)(O═PR3) [R = Ph (5) and Et (6)]. Density functional theory calculations revealed that these reactions proceed via a bimolecular mechanism in which either the basic aluminum(I) center or the transient Al═O species deprotonate the methyl group of the NacNac ligand...
May 2, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28459590/investigation-into-the-effects-of-a-trigonal-planar-ligand-field-on-the-electronic-properties-of-lanthanide-ii-tris-silylamide-complexes-ln-sm-eu-tm-yb
#8
Conrad A P Goodwin, Nicholas F Chilton, Louise S Natrajan, Marie-Emmanuelle Boulon, Joseph W Ziller, William J Evans, David P Mills
In recent work we have reported the synthesis and physical properties of near-linear Ln(II) (Ln = lanthanide) complexes utilizing the bulky bis(silylamide) {N(Si(i)Pr3)2}. Herein, we synthesize trigonal-planar Ln(II) complexes by employing a smaller bis(silylamide), {N(Si(t)BuMe2)2} (N**), to study the effects of this relatively rare Ln geometry/oxidation state combination on the magnetic and optical properties of complexes. We show that the charge-separated trigonal-planar Ln(II) complexes [K(2.2.2-cryptand)][Ln(N**)3] (Ln = Sm (1), Eu (2), Tm (3), Yb (4)) can be prepared by the reaction of 1...
May 1, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28458623/il-32-induced-inflammatory-cytokines-are-selectively-suppressed-by-%C3%AE-1-antitrypsin-in-mouse-bone-marrow-cells
#9
Siyoung Lee, Dong-Ki Choi, Areum Kwak, Sinae Kim, Tam Thanh Nguyen, Gaae Gil, Eunhye Kim, Kwang Ha Yoo, In Ae Kim, Youngmin Lee, Hyunjhung Jhun, Edward D Chan, Xiyuan Bai, Hyunwoo Kim, Yong-Sung Kim, Soohyun Kim
The induction of interleukin (IL)-32 in bone marrow (BM) inflammation is crucial in graft versus host disease (GvHD) that is a common side effect of allogeneic BM transplantation. Clinical trials on α-1 antitrypsin (AAT) in patients with GvHD are based on the preliminary human and mouse studies on AAT reducing the severity of GvHD. Proteinase 3 (PR3) is an IL-32-binding protein that was isolated from human urine. IL-32 primarily induces inflammatory cytokines in myeloid cells, probably due to PR3 expression on the membrane of the myeloid lineage cells...
April 2017: Immune Network
https://www.readbyqxmd.com/read/28450870/neutrophil-extracellular-traps-contain-selected-antigens-of-anti-neutrophil-cytoplasmic-antibodies
#10
Rachita Panda, Thorsten Krieger, Luke Hopf, Thomas Renné, Friedrich Haag, Nadja Röber, Karsten Conrad, Elena Csernok, Tobias A Fuchs
Neutrophil extracellular traps (NETs) are chromatin filaments decorated with enzymes from neutrophil cytoplasmic granules. Anti-neutrophil cytoplasmic antibodies (ANCAs) bind to enzymes from neutrophil cytoplasmic granules and are biomarkers for the diagnosis of systemic vasculitides. ANCA diagnostics are based on indirect immunofluorescence (IIF) of ethanol-fixed neutrophils. IIF shows a cytoplasmic staining pattern (C-ANCA) due to autoantibodies against proteinase 3 (PR3) or a perinuclear staining pattern (P-ANCA) due to autoantibodies against myeloperoxidase (MPO)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28428279/interaction-between-tumor-cell-surface-receptor-rage-and-proteinase-3-mediates-prostate-cancer-metastasis-to-bone
#11
Mikhail G Kolonin, Anna Sergeeva, Daniela I Staquicini, Tracey L Smith, Christy A Tarleton, Jeffrey J Molldrem, Richard L Sidman, Serena Marchiò, Renata Pasqualini, Wadih Arap
Human prostate cancer often metastasizes to bone, but the biological basis for such site-specific tropism remains largely unresolved. Recent work led us to hypothesize that this tropism may reflect pathogenic interactions between RAGE, a cell surface receptor expressed on malignant cells in advanced prostate cancer, and proteinase 3 (PR3), a serine protease present in inflammatory neutrophils and hematopoietic cells within the bone marrow microenvironment. In this study, we establish that RAGE-PR3 interaction mediates homing of prostate cancer cells to the bone marrow...
April 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28413238/formation-of-gold-iii-alkyls-from-gold-alkoxide-complexes
#12
Isabelle Chambrier, Dragoş-Adrian Roşca, Julio Fernandez-Cestau, David L Hughes, Peter H M Budzelaar, Manfred Bochmann
The gold(III) methoxide complex (C(∧)N(∧)C)AuOMe (1) reacts with tris(p-tolyl)phosphine in benzene at room temperature under O abstraction to give the methylgold product (C(∧)N(∧)C)AuMe (2) together with O=P(p-tol)3 ((C(∧)N(∧)C) = [2,6-(C6H3(t) Bu-4)2pyridine](2-)). Calculations show that this reaction is energetically favorable (ΔG = -32.3 kcal mol(-1)). The side products in this reaction, the Au(II) complex [Au(C(∧)N(∧)C)]2 (3) and the phosphorane (p-tol)3P(OMe)2, suggest that at least two reaction pathways may operate, including one involving (C(∧)N(∧)C)Au(•) radicals...
April 10, 2017: Organometallics
https://www.readbyqxmd.com/read/28406290/cooperative-catalysis-at-metal-sulfur-bonds
#13
Lukas Omann, C David F Königs, Hendrik F T Klare, Martin Oestreich
Cooperative catalysis has attracted tremendous attention in recent years, emerging as a key strategy for the development of novel atom-economic and environmentally more benign catalytic processes. In particular, Noyori-type complexes with metal-nitrogen bonds have been extensively studied and evolved as privileged catalysts in hydrogenation chemistry. In contrast, catalysts containing metal-sulfur bonds as the reactive site are out of the ordinary, despite their abundance in living systems, where they are assumed to play a key role in biologically relevant processes...
April 13, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28391334/complement-activation-in-pauci-immune-necrotizing-and-crescentic-glomerulonephritis-results-of-a-proteomic-analysis
#14
Sanjeev Sethi, Ladan Zand, An S De Vriese, Ulrich Specks, Julie A Vrana, Siddak Kanwar, Paul Kurtin, Jason D Theis, Andrea Angioi, Lynn Cornell, Fernando C Fervenza
Background: Complement activation plays an important role in the pathophysiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), although it remains unclear which pathway is activated. Whether pauci-immune necrotizing crescentic glomerulonephritis (pauci-immune GN) with negative ANCA serology is part of the spectrum of AAV or a different disease entity is essentially unknown. Methods: We used proteomic analysis to delineate the complement profile in a series of 13 kidney biopsies of patients with pauci-immune GN, with either proteinase 3 (PR3) (five patients) or myeloperoxidase (MPO) antibodies (four patients) or with consistently negative ANCA serology (four patients)...
January 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28368595/-fe4-and-fe6-hydride-clusters-supported-by-phosphines-synthesis-characterization-and-application-in-n2-reduction
#15
Ryoichi Araake, Kazuki Sakadani, Mizuki Tada, Yoichi Sakai, Yasuhiro Ohki
Multiple iron atoms bridged by hydrides is a common structural feature of the active species that have been postulated in the biological and industrial reduction of N2. In this study, the reactions of an Fe(II) amide complex with pinacolborane in the presence/absence of phosphines afforded a series of hydride-supported [Fe4] and [Fe6] clusters Fe4(μ-H)4(μ3-H)2{N(SiMe3)2}2(PR3)4 (PR3 = PMe3 (2a), PMe2Ph (2b), PEt3 (2c)), Fe6(μ-H)10(μ3-H)2(PMe3)10 (3), and (η(6)-C7H8)Fe4(μ-H)2{μ-N(SiMe3)2}2{N(SiMe3)2}2 (4), which were characterized crystallographically and spectroscopically...
April 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28361331/anca-associated-vasculitis-pathogenesis-a-commentary
#16
REVIEW
Eric J Gapud, Philip Seo, Brendan Antiochos
PURPOSE OF REVIEW: The ANCA-associated vasculitides are a group of small vessel vasculitides characterized by autoantibodies recognizing the neutrophil cytoplasmic antigens PR3 and MPO. We examine the current clinical and molecular immunology understanding of ANCA-associated vasculitides and discuss the current needs in our understanding of the pathogenic mechanisms of these rare diseases. RECENT FINDINGS: The majority of efforts to understand the pathogenesis of these diseases have focused on dissecting neutrophil biology because the neutrophil is the primary expressor of ANCA autoantigens...
April 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28339364/clinical-and-prognostic-features-of-korean-patients-with-mpo-anca-pr3-anca-and-anca-negative-vasculitis
#17
Juyoung Yoo, Ho Jae Kim, Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
OBJECTIVES: We reclassified Korean patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) into 3 categories of AAV including MPO-ANCA, PR3-ANCA and ANCA-negative vasculitis, and investigated clinical and prognostic features. METHODS: We reviewed the medical records of 133 patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA), who had either myeloperoxidase (MPO)-ANCA, proteinase 3 (PR3)-ANCA or no ANCA, and who had ever achieved the first remission...
March 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28319294/activation-of-sf6-at-platinum-complexes-formation-of-sf3-derivatives-and-their-application-in-deoxyfluorination-reactions
#18
Claudia Berg, Thomas Braun, Mike Ahrens, Philipp Wittwer, Roy Herrmann
The activation of SF6 at [Pt(PR3 )2 ] R=Cy, iPr complexes in the presence of PR3 led selectively and in an unprecedented reaction route to the generation of the SF3 complexes trans-[Pt(F)(SF3 )(PR3 )2 ]. These can also be synthesized from SF4 and the SF2 derivative trans-[Pt(F)(SF2 )(PCy3 )2 ][BF4 ] was characterized by X-ray crystallography. trans-[Pt(F)(SF3 )(PR3 )2 ] complexes are useful tools for deoxyfluorination reactions and novel fluorido complexes bearing a SOF ligand are formed. Based on these studies a process for the deoxyfluorination of ketones was developed with SF6 as fluorinating agent...
April 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28291538/-pyoderma-gangrenosum-associated-with-anti-proteinase-3%C3%A2-antineutrophil-cytoplasmic-antibodies-pr3-anca-induced-by-propylthiouracil
#19
A Coster, J-L Dargent, N de Visscher, P Levecque, P-P Roquet-Gravy
BACKGROUND: Synthetic antithyroid drugs are often used in the treatment of hyperthyroidism, regardless of aetiology. They may cause various side effects, including the development of anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis, and neutrophilic dermatoses. Propylthiouracil (PTU) is the antithyroid drug most frequently implicated in ANCA-associated diseases specifically involving anti-myeloperoxidase ANCA (MPO-ANCA). To our knowledge, there are no clinical reports describing the association of pyoderma gangrenosum (PG) and anti-proteinase3-ANCA (PR3-ANCA) induced by PTU, with ANCA levels decreasing after antithyroid drug withdrawal...
March 10, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28276554/1-8-bis-silylamido-naphthalene-complexes-of-magnesium-and-zinc-synthesised-through-alkane-elimination-reactions
#20
Mark A Bradley, Chris Birchall, Alexander J Blake, William Lewis, Graeme J Moxey, Deborah L Kays
The reactions between magnesium or zinc alkyls and 1,8-bis(triorganosilyl)diaminonaphthalenes afford the 1,8-bis(triorganosilyl)diamidonaphthalene complexes with elimination of alkanes. The reaction between 1,8-C10H6(NSiMePh2H)2 and one or two equivalents of Mg(n)Bu2 affords two complexes with differing coordination environments for the magnesium; the reaction between 1,8-C10H6(NSiMePh2H)2 and Mg(n)Bu2 in a 1 : 1 ratio affords 1,8-C10H6(NSiMePh2)2{Mg(THF)2} (1), which features a single magnesium centre bridging both ligand nitrogen donors, whilst treatment of 1,8-C10H6(NSiR3H)2 (R3 = MePh2, (i)Pr3) with two equivalents of Mg(n)Bu2 affords the bimetallic complexes 1,8-C10H6(NSiR3)2{(n)BuMg(THF)}2 (R3 = MePh22, R3 = (i)Pr33), which feature four-membered Mg2N2 rings...
March 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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