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https://www.readbyqxmd.com/read/28715006/substitution-reactions-of-iron-ii-carbamoyl-thioether-complexes-related-to-mono-iron-hydrogenase
#1
Zhu-Lin Xie, Gummadi Durgaprasad, Azim K Ali, Michael J Rose
A C,N,S pincer complex has been synthesized for structural modeling of the organometallic active site of mono-[Fe] hydrogenase (HMD). The C,N,S chelate allows for systematic investigation of the substitution reactions of CO and other exogenous X/L-type ligands, as well as examination of the exact roles of the Fe-carbamoyl and {Fe(CO)2}(2+) units in stabilizing the low-spin Fe(ii) center. Reaction of the 'apo-ligand' 6-(2-(methylthio)phenyl)pyridin-2-amine ((H2N)N(py)S(Me)) with [Fe(CO)4(Br)2] affords the organometallic complex [((O[double bond, length as m-dash])C(NH)N(py)S(Me))Fe(CO)2(Br)] (1)...
July 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28710880/an-international-survey-on-anti-neutrophil-cytoplasmic-antibodies-anca-testing-in-daily-clinical-practice
#2
Jan Damoiseaux, Ingmar Heijnen, Christel Van Campenhout, Catharina Eriksson, Nicole Fabien, Manfred Herold, Renate G van der Molen, William Egner, Dina Patel, Aresio Plaza-Lopez, Antonella Radice, Marie José Rego de Sousa, Markku Viander, Yehuda Shoenfeld
BACKGROUND: Detection of anti-neutrophil cytoplasmic antibodies (ANCA) is important for the diagnosis of the ANCA-associated vasculitides (AAV). For AAV, especially ANCA directed against myeloperoxidase (MPO) and proteinase 3 (PR3) are most relevant. ANCA with less well-defined specificities may, however, also be detected in other inflammatory and non-inflammatory conditions. METHODS: A questionnaire, initiated by the European Autoimmunity Standardisation Initiative (EASI), was used to gather information on methods and testing algorithms used for ANCA in clinical laboratories of 12 European countries (EASI survey)...
July 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28683653/optimization-of-human-myocardium-decellularization-method-for-the-construction-of-implantable-patches
#3
Franca Di Meglio, Daria Nurzynska, Veronica Romano, Rita Miraglia, Immacolata Belviso, Anna Maria Sacco, Valeria Barbato, Mariagrazia Di Gennaro, Giuseppina Granato, Ciro Maiello, Stefania Montagnani, Clotilde Castaldo
Cardiac tissue engineering by the mean of synthetic or natural scaffolds combined with stem/progenitor cells is emerging as the response to the unsatisfactory outcome of approaches based solely on the injection of cells. Parenchymal and supporting cells are surrounded, in vivo, by specialized and tissue-specific microenvironment, consisting mainly of extracellular matrix (ECM) and soluble factors incorporated in the ECM. Since the naturally occurring extracellular matrix is the ideal platform for ensuring cell engraftment, survival, proliferation, and differentiation, the acellular native ECM appears by far the most promising and appealing substrate among all biomaterials tested so far...
July 6, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28681726/a-case-of-cutaneous-polyarteritis-nodosa-with-pr3-anca
#4
Ellen Toyonaga, Hiroaki Iwata, Shinichi Nakazato, Yusuke Morita, Ichiro Takahashi, Hiroshi Shimizu
No abstract text is available yet for this article.
July 5, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28678257/insulated-molecular-wires-inhibiting-orthogonal-contacts-in-metal-complex-based-molecular-junctions
#5
Oday A Al-Owaedi, Sören Bock, David C Milan, Marie-Christine Oerthel, Michael S Inkpen, Dmitry S Yufit, Alexandre N Sobolev, Nicholas J Long, Tim Albrecht, Simon J Higgins, Martin R Bryce, Richard J Nichols, Colin J Lambert, Paul J Low
Metal complexes are receiving increased attention as molecular wires in fundamental studies of the transport properties of metal|molecule|metal junctions. In this context we report the single-molecule conductance of a systematic series of d(8) square-planar platinum(ii) trans-bis(alkynyl) complexes with terminal trimethylsilylethynyl (C[triple bond, length as m-dash]CSiMe3) contacting groups, e.g. trans-Pt{C[triple bond, length as m-dash]CC6H4C[triple bond, length as m-dash]CSiMe3}2(PR3)2 (R = Ph or Et), using a combination of scanning tunneling microscopy (STM) experiments in solution and theoretical calculations using density functional theory and non-equilibrium Green's function formalism...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28667707/gly-decorated-praseodymium-stabilized-nanosized-selenotungstate-cluster-synthesis-structure-and-oxidation-catalysis
#6
Jingyang Niu, Ling Yang, Jipeng Guo, Li Li, Qisen Liu, Pengtao Ma, Jingping Wang
A flexible one-pot strategy exploiting pyramidal SeIV heteroatom is employed for the assembly of praseodymium-containing gly-decorated polyoxotungstate [{Pr3(H2O)10[Se2W22O76(gly)2]}2(Se2W7O30H2)]18- (1a), which is constructed from one {Se2W7O30H2} unit and two identical {Pr3(H2O)10[Se2W22O76(gly)2]} units. Furthermore, the catalytic performance of Cs2Na4H12[{Pr3(H2O)10[Se2W22O76(gly)2]}2 (Se2W7O30H2)]∙25H2O (1) for alkenes epoxidation with hydrogen peroxide was investigated under mild reaction conditions...
July 1, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28666565/a-novel-strategy-with-combined-assays-for-detection-of-anti-neutrophil-cytoplasmic-antibody-anca-in-clinically-anca-negative-granulomatosis-with-polyangiitis-patients
#7
Kaori Tateyama, Satoru Kodama, Kan Kishibe, Yasuaki Harabuchi, Masashi Suzuki
OBJECTIVE: Granulomatosis with polyangiitis (GPA) that is localized to the upper airway presents a diagnostic challenge because of a tendency towards anti-neutrophil cytoplasmic antibody (ANCA)-negativity. The purpose of this study was to investigate whether positivity of ANCA detection might be elicited with combined use of enzyme-linked immunosorbent assay (ELISA) kits. METHODS: Twenty-nine serum samples obtained from GPA patients were used in this study. In addition to routine biochemical investigation for ANCA, tests for detecting PR3-, MPO-ANCAs, and minor ANCAs were performed with commercially available ELISA kits...
June 27, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28650612/superionic-conductivity-of-sm-3-pr-3-and-nd-3-triple-doped-ceria-through-bulk-and-surface-two-step-doping-approach
#8
Yanyan Liu, Liangdong Fan, Yixiao Cai, Wei Zhang, Baoyuan Wang, Bin Zhu
Sufficiently high oxygen ion conductivity of electrolyte is critical for good performance of low-temperature solid oxide fuel cells (LT-SOFCs). Notably, material conductivity, reliability, and manufacturing cost are the major barriers hindering LT-SOFC commercialization. Generally, surface properties control the physical and chemical functionalities of materials. Hereby, we report a Sm(3+), Pr(3+), and Nd(3+) triple-doped ceria, exhibiting the highest ionic conductivity among reported doped-ceria oxides, 0...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28592297/negative-anti-neutrophil-cytoplasm-antibody-at-switch-to-maintenance-therapy-is-associated-with-a-reduced-risk-of-relapse
#9
Matthew David Morgan, Matthew Szeto, Michael Walsh, David Jayne, Kerstin Westman, Niels Rasmussen, Thomas F Hiemstra, Oliver Flossmann, Annelies Berden, Peter Höglund, Lorraine Harper
BACKGROUND: Relapse of disease is frequent in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). It is unclear whether persistent ANCA when starting maintenance therapy increases the risk of relapse. We examined the association between ANCA status and relapse in two randomised controlled trials. METHODS: ANCA-positive patients in two trials, CYCLOPS and IMPROVE, were switched from cyclophosphamide to maintenance therapy after achieving clinical remission...
June 7, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28588684/successful-treatment-of-granulomatosis-with-polyangiitis-with-hydropneumothorax-using-corticosteroids-and-immunosuppressant
#10
Xu-Hua Shi, Yong-Feng Zhang, Yue-Wu Lu
Pneumothorax and pleural effusion is a rare and serious complication of granulomatosis with polyangiitis (GPA). The present study reported a case with a history of sinusitis for 20 years, dry cough for three years and exacerbated purulent nasal discharge and recurrent skin ulcers for two years. The patient experienced sudden difficulty in breathing two months prior to presentation. Lung computed tomography (CT) showed multiple bilateral lung nodules and cavitary nodules as well as right hydropneumothorax. Paranasal sinus CT showed soft tissue infiltration...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28567264/multi-electron-reactivity-of-a-cofacial-di-tin-ii-cryptand-partial-reduction-of-sulfur-and-selenium-and-reversible-generation-of-s3%C3%AB
#11
Julia M Stauber, Peter Müller, Yizhe Dai, Gang Wu, Daniel G Nocera, Christopher C Cummins
Cofacial bimetallic tin(ii) ([Sn2(mBDCA-5t)](2-), 1) and lead(ii) ([Pb2(mBDCA-5t)](2-), 2) complexes have been prepared by hexadeprotonation of hexacarboxamide cryptand mBDCA-5t-H6 together with double Sn(ii) or Pb(ii) insertion. Reaction of 1 with elemental sulfur or selenium generates di-tin polychalcogenide complexes containing μ-E and bridging μ-E5 ligands where E = S or Se, and the Sn(ii) centers have both been oxidized to Sn(iv). Solution and solid-state UV-Vis spectra of [(μ-S5)Sn2(μ-S)(mBDCA-5t)](2-) (4) indicate that the complex acts reversibly as a source of S3˙(-) in DMF solution with a Keq = 0...
December 1, 2016: Chemical Science
https://www.readbyqxmd.com/read/28549721/comparison-of-enzyme-linked-immunosorbent-assay-and-rapid-chemiluminescent-analyser-in-the-detection-of-myeloperoxidase-and-proteinase-3-autoantibodies
#12
Phillippa A Pucar, Carolyn A Hawkins, Katrina L Randall, Candice Li, Euan McNaughton, Matthew C Cook
Antibodies to myeloperoxidase (MPO) and proteinase 3 (PR3) are vital in the diagnosis and management of ANCA-associated vasculitis. A chemiluminescent immunoassay (CLIA; Quanta Flash) provides MPO and PR3 antibody results in 30 minutes, which is much faster than enzyme-linked immunosorbent assay (ELISA). We compared the performance of ELISA (Orgentec) and CLIA (Quanta Flash) for MPO and PR3 antibody quantitation on 303 samples, comprising 196 consecutive samples received in a single diagnostic laboratory over a 3 month period, and 107 samples collected from 42 known vasculitis patients over a 40 month period...
June 2017: Pathology
https://www.readbyqxmd.com/read/28548179/threading-of-various-u-shaped-bidentate-axles-into-a-heteroditopic-macrocyclic-wheel-via-ni-ii-cu-ii-templation
#13
Mandira Nandi, Saikat Santra, Bidyut Akhuli, Pradyut Ghosh
The threading of 'U' shaped bent axles having diverse functionalities (Axle1-Axle10) is investigated by using a heteroditopic amido-amine macrocyclic (MC) wheel via Ni(II) or Cu(II) metal ion templation. These bent shaped axles are the derivatives of 4,4'-substituted 2,2'-bipyridine, which are composed of various terminal groups like alkene, alkyne, bromide, hydroxyl and azide. Such metallo [2]pseudorotaxanes are well characterised by ESI-MS, EPR and FT-IR spectroscopic studies, UV-Vis absorption studies, elemental analysis and single-crystal X-ray diffraction studies wherever possible...
June 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28546501/proteinase-3-the-odd-one-out-that-became-an-autoantigen
#14
REVIEW
Katherine R Martin, Véronique Witko-Sarsat
Neutrophils are critical in the defense against bacterial and fungal pathogens, and they also modulate the inflammatory process. The areas where neutrophils are studied have expanded from the restricted field of antibacterial defense to the modulation of inflammation and finally, to fine-tuning immune responses. As a result, recent studies have shown that neutrophils are implicated in several systemic autoimmune diseases, although exactly how neutrophils contribute to these diseases and the molecular mechanisms responsible are still under investigation...
May 25, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28544838/granulomatosis-with-polyangiitis-presenting-with-acute-aortic-and-mitral-regurgitation-case-report-and-big-data-analysis
#15
Sadeer G Al-Kindi, M Amer Al-Aiti, Michael Yang, Richard A Josephson
Granulomatosis with polyangiitis (GPA) is a rare vasculitis that can have multisystem involvement, though cardiac involvement is very rare. The case is described of a 53-year-old woman who presented with acute aortic and mitral valve regurgitation requiring surgical intervention. Pathology from the excised aortic valve showed geographic necrosis concerning for GPA. Subsequent rheumatologic testing was positive for anti-serine proteinase 3 (PR3) antibody, consistent with GPA. A year after the valve surgery the patient was found to have a vegetation of the mitral valve and elevated PR3 antibody levels, and was successfully treated with an intensification of immunosuppression...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28541581/a-multicentre-study-to-improve-clinical-interpretation-of-proteinase-3-and-myeloperoxidase-anti-neutrophil-cytoplasmic-antibodies
#16
Xavier Bossuyt, Niels Rasmussen, Pieter van Paassen, Bernard Hellmich, Bo Baslund, Pieter Vermeersch, Daniel Blockmans, Jan-Willem Cohen Tervaert, Elena Csernok, Jan Damoiseaux
Objective.: The objective of this multicentre study was to improve the clinical interpretation of PR3- and MPO-ANCAs as an adjunct for the diagnosis of ANCA-associated vasculitis (AAV) by defining thresholds and test result intervals based on predefined specificities and by calculating test result interval-specific likelihood ratios (LRs). Methods.: Eight different PR3- and MPO-ANCA immunoassays from seven companies were evaluated using 251 diagnostic samples from AAV patients and 924 diseased controls...
May 24, 2017: Rheumatology
https://www.readbyqxmd.com/read/28540968/synthetic-and-structural-studies-of-phosphine-coordinated-boronium-salts
#17
Anthony F Hill, Jas S Ward
The reaction of BrH2B·SMe2 with primary and secondary phosphines affords a range of boronium salts of the form [H2B(PR3)2]Br (PR3 = PHCy21; PHPh2, 2; PH2Cy, 3), which have been fully characterised including solid-state determinations. Reactions of bulky tertiary phosphines, e.g., PCy3 and PPh3, with BrH2B·SMe2 do not proceed beyond the phosphine-stabilised bromoborane adducts, however, the smaller tertiary phosphine PMe2Ph readily proceeds to form [H2B(PMe2Ph)2]Br (4). The formation of the unsymmetrical boronium salts [H2B(PH2Cy)(PHCy2)]Br (5) and [H2B(PHCy2)(PHPh2)]Br (6) was observed by in situ NMR spectroscopy, however, the compounds were found to spontaneously disproportionate to their respective homophosphine boronium cations, even on prolonged storage in solution at -78 °C...
June 6, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28514287/concurrent-igg4-related-tubulointerstitial-nephritis-and-igg4-myeloperoxidase-anti-neutrophil-cytoplasmic-antibody-positive-crescentic-glomerulonephritis-a-case-report
#18
Tao Su, Li Yang, Zhao Cui, Su-Xia Wang, Ming-Hui Zhao
RATIONALE: IgG4-related disease (IgG4-RD) is a newly recognized systemic disease. The typical pathological finding in the kidney is abundant IgG4-positive plasma cell infiltration with characteristic storiform fibrosis in the interstitium. Antibodies of the IgG4 subclass have been linked to certain autoimmune diseases including antiproteinase 3 (PR3) anti-neutrophil cytoplasmic antibody (ANCA) of the IgG4 subclass. Here, we report a rare case of kidney injury with concurrent typical IgG4-related tubulointerstitial nephritis and IgG4 subclass of myeloperoxidase (MPO) ANCA-positive necrotizing crescentic glomerulonephritis...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28513131/improved-oxidase-mimetic-activity-by-praseodymium-incorporation-into-ceria-nanocubes
#19
Lei Jiang, Susana Fernandez-Garcia, Miguel Tinoco, Zhaoxia Yan, Qi Xue, Ginesa Blanco, Jose J Calvino, Ana B Hungria, Xiaowei Chen
Ceria nanocubes (NC) modified with increasing concentrations of praseodymium (5, 10, 15, and 20 mol %) have been successfully synthesized by a hydrothermal method. The as-synthesized Pr-modified ceria nanocubes exhibit an enhanced oxidase-like activity on the organic dye TMB within a wide range of concentrations and durations. The oxidase activity increases with increasing Pr amounts in Pr-modified ceria nanocubes within the investigated concentration range. Meanwhile, these Pr-modified ceria nanocubes also show higher reducibility than pure ceria nanocubes...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28509135/renal-limited-vasculitis-with-elevated-levels-of-multiple-antibodies
#20
Noriaki Sato, Hideki Yokoi, Hirotaka Imamaki, Eiichiro Uchino, Kaoru Sakai, Takeshi Matsubara, Tatsuo Tsukamoto, Sachiko Minamiguchi, Motoko Yanagita
Renal-limited vasculitis (RLV) is a type of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis that presents with crescentic glomerulonephritis with no other organ involvement. Although several studies reported patients with crescentic glomerulonephritis who were dual positive for proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA or ANCA and anti-glomerular basement membrane (GBM) antibody, patients positive for all three antibodies, i.e., triple-positive patients, were rarely reported. We herein report the case of a male with pauci-immune type crescentic glomerulonephritis positive for MPO-ANCA, PR3-ANCA, and anti-GBM antibody...
May 2017: CEN Case Reports
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