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Ji-Min Fan, Zhi-Huan Zhao, Chao Gong, Yong-Qiang Xue, Shu Yin
Metal ions (Cr, Ni, Co) doped titania (M-TiO2) coupled with the long after glow phosphor MgAl2O4:(Pr3+, Dy3+) particles were synthesized by the sol-gel method, with the best mass ratio of MgAl2O4:(Pr3+, Dy3+) to M-TiO2 as 4:6. MgAl2O4:(Pr3+, Dy3+)/M-TiO2 had the persistent methyl orange (MO) photocatalytic degradation ability and the photocatalytic degradation went on reacting more than 90 min in dark after turning off the light. MgAl2O4:(Pr3+, Dy3+) emitted the light as a light source in dark which was absorbed by M-TiO2...
March 1, 2018: Journal of Nanoscience and Nanotechnology
David B G Oliveira
The small vessel vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis are associated with autoantibodies to neutrophil cytoplasm antigens (ANCA), principally proteinase-3 (PR3) and myeloperoxidase (MPO). There is an association between GPA and nasal carriage of Staphylococcus aureus. The recent finding that S. aureus produces proteins that bind tightly to and block the function of both PR3 and MPO suggests a mechanism for ANCA formation. The bacterial protein-autoantigen conjugate is recognised by B cells with ANCA specificity, internalised, and the bacterial protein processed and presented to T cells with specificity for bacterial peptides...
March 2018: Medical Hypotheses
Carla Guarino, Natalia Gruba, Renata Grzywa, Edyta Dyguda-Kazimierowicz, Yveline Hamon, Monika Legowska, Marcin Skoreński, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Christine Kellenberger, Dieter E Jenne, Marcin Sieńczyk, Adam Lesner, Francis Gauthier, Brice Korkmaz
The neutrophilic serine protease proteinase 3 (PR3) is involved in inflammation and immune response and thus appears as a therapeutic target for a variety of infectious and inflammatory diseases. Here we combined kinetic and molecular docking studies to increase the potency of peptidyl-diphenyl phosphonate PR3 inhibitors. Occupancy of the S1 subsite of PR3 by a nVal residue and of the S4-S5 subsites by a biotinylated Val residue as obtained in biotin-VYDnVP(O-C6H4-4-Cl)2 enhanced the second order inhibition constant kobs/[I] towards PR3 by more than ten times (kobs/[I] = 73...
February 14, 2018: Journal of Medicinal Chemistry
Kseniya Popovich, Kateřina Tomanová, Václav Čuba, Lenka Procházková, Iveta Terezie Pelikánová, Ivo Jakubec, Eva Mihóková, Martin Nikl
A highly prospective drug for the X-ray induced photodynamic therapy (PDTX), LuAG:Pr3+@SiO2-PpIX nanocomposite, was successfully prepared by a three step process: photo-induced precipitation of the Lu3Al5O12:Pr3+ (LuAG:Pr3+) core, sol-gel technique for amorphous silica coating, and a biofunctionalization by attaching the protoporphyrin IX (PpIX) molecules. The synthesis procedure provides three-layer nanocomposite with uniform shells covering an intensely luminescent core. Room temperature radioluminescence (RT RL) spectra as well as photoluminescence (RT PL) steady-state and time resolved spectra of the material confirm the non-radiative energy transfer from the core Pr3+ ions to the PpIX outer layer...
February 1, 2018: Journal of Photochemistry and Photobiology. B, Biology
Sushant P Sahu, Stephanie L Cates, Hyoung-Il Kim, Jae-Hong Kim, Ezra L Cates
Upconversion luminescence is a nonlinear optical process achieved by certain engineered materials, which allows conversion of low energy photons into higher energy photons. Of particular relevance to environmental technology, lanthanide-based upconversion phosphors have appeared in dozens of publications as a tool for achieving visible light activation of wide-band gap semiconductor photocatalysts, such as TiO2, for degradation of water contaminants. Supposedly, the phosphor particles act to convert sub-band gap energy photons (e...
February 6, 2018: Environmental Science & Technology
S Sattayaporn, P Loiseau, G Aka, D-T Marzahl, C Kränkel
We report on the crystal growth, spectroscopic properties and visible laser performances of Pr3+-doped Sr0.7La0.3Mg0.3Al11.7O19 (ASL). ASL crystals doped with 2 at.% and 4 at.% Pr3+ were grown by Czochralski method. The laser experiments were carried out in a plane-concave resonator under excitation at 486 nm, provided from a 2ω-OPSL. Efficient laser emission was obtained with an 8 mm long sample of Pr(2at.%):ASL. The maximum output power amounted to 267 mW, 52 mW, and 318 mW at an absorbed power of 1.2W for red, orange, and deep red emission, respectively...
January 22, 2018: Optics Express
Elena Csernok, Juliane Mahrhold, Bernhard Hellmich
The current practice for detection of anti-neutrophil cytoplasm antibodies (ANCA) directed against proteinase 3 (PR3) and myeloperoxidase (MPO) has been screening by indirect immunofluorescence (IIF) followed by an antigen specific tests for PR3- and MPO-ANCA. However, ANCA diagnostics have undergone many technical developments that have affected the 1999 international consensus recommendations, and lead to a revision of the existing ANCA detection strategy. Recent European multicentre studies have compared the diagnostic performance of various ANCA detection methods and demonstrated that PR3- and MPO-ANCA immunoassays yielded the highest diagnostic accuracy...
January 27, 2018: Journal of Immunological Methods
Ameni Jerbi, Sawsan Feki, Salma Ben Ameur, Hend Hachicha, Lamia Gargouri, Thouraya Kamoun, Abdelmajid Mahfoudh, Mongia Hachicha, Hatem Masmoudi
In adults, anti-neutrophil cytoplasmic antibodies (ANCA) are considered as serological markers of several diseases, especially vasculitis and glomerulonephritis. Since ANCA are rarely positive in children, few data about the clinical relevance of these auto-antibodies in pediatric population have been reported. Therefore, our study aims to describe the spectrum of disorders associated with positive ANCA in Tunisian children. This study had been carried out over a period of 12 years and a half. All patients under the age of 15 for whom ANCA screening was performed in our laboratory were included...
January 1, 2018: Annales de Biologie Clinique
Richard C Knighton, Jack Emerson-King, Jonathan P Rourke, C André Ohlin, Adrian B Chaplin
A homologous family of low-coordinate complexes of the formulation trans-[M(2,2'-biphenyl)(PR3)2][BArF4] (M = Rh, Ir; R = Ph, Cy, iPr, iBu) has been prepared and extensively structurally characterised. Enabled through a comprehensive set of solution (VT 1H and 31P NMR spectroscopy) and solid-state (single crystal X-ray diffraction) data, and analysis in silico (DFT-based NBO and QTAIM analysis), the structural features of the constituent agostic interactions have been systematically interrogated. The combined data substantiates the adoption of stronger agostic interactions for the Ir(III) compared to Rh(III) complexes and, with respect to the phosphine ligands, in the order PiBu3 > PCy3 > PiPr3 > PPh3...
January 26, 2018: Chemistry: a European Journal
Abdulla Watad, Nicola L Bragazzi, Kassem Sharif, Boris Gilburd, Yarden Yavne, Dennis McGonagle, Howard Amital, Yehuda Shoenfeld
BACKGROUND: Enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence (IIF) are the best strategies for antineutrophil cytoplasmic antibodies (ANCA) detection. In a minority of subjects, ELISA-based ANCA testing may result in a borderline positive titre. Therefore, we assessed the clinical significance of such a result. METHODS: This is a retrospective study, which included all subjects screened for ANCA subtypes (myeloperoxidase/MPO or proteinase-3/PR3) with subsequent identification of borderline positive results, as determined by ELISA and retested using IIF...
January 29, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Marion Haubitz
In patients with ANCA-associated vasculitis renal involvement is frequently seen and the severity of renal manifestation is very important for therapeutic strategies and prognosis. Clinically rapid loss of renal function, nephritic sediment and proteinuria in a non-nephrotic range are characterizing a focal segmental necrotizing pauci-immune glomerulonephritis with extrarenal proliferations. Induction treatment depends on the severity of manifestations. With a normal renal function methotrexate can be used in combination with steroids...
January 2018: Deutsche Medizinische Wochenschrift
Salomé Muray Cases, Concepción Alcázar Fajardo, Juan B Cabezuelo Romero
No abstract text is available yet for this article.
January 18, 2018: Archivos de Bronconeumología
Hechen Wu, Rong Wan, Yanan Si, Pengtao Ma, Jingping Wang, Jingyang Niu
A 1-D infinite helical chain-like organic-inorganic hybrid arsenotungstate Na4H8[{Pr(H2O)2}2{As2W19O68}{WO2(mal)}2]·24H2O (mal = malate) (1) was prepared, which was characterized by elemental analyses, thermogravimetric (TG) analyses, IR spectroscopy, powder X-ray diffraction (PXRD) and X-ray single-crystal diffraction. Structural characterization revealed that 1 comprises the organo-functionalized [{As2W19O68}{WO2(mal)}2]18- polyanions hinged together by the Pr3+ ions forming a 1-D infinite helical chain-like architecture...
January 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Antoine Néel, Alexandra Espitia-Thibault, Pierre-Paul Arrigoni, Christelle Volteau, Marie Rimbert, Agathe Masseau, Christian Agard, Fadi Fakhouri, Renan Liberge, Mohamed Hamidou
OBJECTIVES: To assess the prevalence of bronchiectasis in a Western cohort with ANCA-positive granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) and its correlations with disease presentation and outcome. METHODS: Retrospective study of ANCA-associated vasculitis (AAV) patients followed at Nantes University Hospital (2005-2015). Clinical, biological, and follow-up data were collected through chart review. Two experienced radiologists blinded to the clinical data interpreted chest high-resolution CTs according to the Feischner Society criteria...
December 7, 2017: Seminars in Arthritis and Rheumatism
Sierra C Marker, Samantha N MacMillan, Warren R Zipfel, Zhi Li, Peter C Ford, Justin J Wilson
Fifteen water-soluble rhenium compounds of the general formula [Re(CO)3(NN)(PR3)]+, where NN is a diimine ligand and PR3 is 1,3,5-triaza-7-phosphaadamantane (PTA), tris(hydroxymethyl)phosphine (THP), or 1,4-diacetyl-1,3,7-triaza-5-phosphabicylco[3.3.1]nonane (DAPTA), were synthesized and characterized by multinuclear NMR spectroscopy, IR spectroscopy, and X-ray crystallography. The complexes bearing the THP and DAPTA ligands exhibit triplet-based luminescence in air-equilibrated aqueous solutions with quantum yields ranging from 3...
January 11, 2018: Inorganic Chemistry
Gabriel Marineau-Plante, Frank Juvenal, Adam Langlois, Daniel Fortin, Armand Soldera, Pierre D Harvey
The complexes (R = Me, Et, Bu; X = H, SMe) exhibit well-defined multi-exponential emissions (2-4 components) in the solid state at 77 and 298 K and in 2MeTHF glasses at 77 K due to multiple frozen conformers exhibiting variable dihedral angles formed by the PtP2C2 and C6H4 planes. The demonstration was made using X-ray crystallography at various temperatures where different sites are present in the samples, and using geometry optimization (DFT computations) where various stable conformers are noted.
January 10, 2018: Chemical Communications: Chem Comm
Yoshie Ojima, Kinya Sawada, Hiroshi Fujii, Tsuyoshi Shirai, Ayako Saito, Saeko Kagaya, Satoshi Aoki, Yoichi Takeuchi, Tomonori Ishii, Tasuku Nagasawa
A previously healthy 58-year-old man was admitted for muscle pain and weakness (manual muscle testing [MMT] of 4/4 for upper and lower limbs). We detected elevated levels of inflammatory makers and PR3-anti-neutrophil cytoplasmic antibody (ANCA). Subsequently, the muscle weakness rapidly progressed to an MMT of 2 for all limbs. Magnetic resonance imaging indicated muscle edema, and the CK level increased to 29,998 U/L. mPSL and cyclophosphamide pulse therapy improved the patient symptoms. MMT recovered to 4 for all limbs...
December 27, 2017: Internal Medicine
Masanori Kurihara, Yu Kurata, Izumi Sugimoto, Yuki Hatanaka, Yasuhisa Sakurai
Proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) is reported to be highly specific to vasculitis compared to myeloperoxidase (MPO)-ANCA. We report a case of a 19-year-old woman with chronic inflammatory demyelinating polyneuropathy (CIDP) with high PR3-ANCA positivity. The patient responded well to intravenous immunoglobulin plus oral steroid, and showed no signs of systemic vasculitis during the subsequent 10 months of follow-up. Our present case suggests that CIDP may accompany high PR3-ANCA levels, which should be differentiated from axonal neuropathy due to vasculitis...
March 2017: ENeurologicalSci
Takao Kiboshi, Kentaro Isoda, Koichi Furukawa, Tomoyuki Wakahara, Kenichiro Otani, Kayo Ueda, Junichi Konma, Kazuhiro Teramura, Nozomi Ueno, Hiroshi Fujiwara, Takeshi Shoda
  A 51-year-old man was detected nasal bleeding, multiple pulmonary nodule and mass, urinalysis abnormality, renal involvement and high titer of proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA), and was suspected of granulomatosis with polyangiitis and initiated with steroid pulse therapy. On the day after the start of steroid pulse therapy, generalized peritonitis due to ileal perforation occurred, and emergency ileectomy and peritonitis surgery were performed. Induction therapy with steroid pulse therapy, plasma exchange and intravenous cyclophosphamide therapy (IVCY) and maintenance therapy with glucocorticoid and azathioprine led to good therapeutic outcomes...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
Gayathri Bharathan, Robert I Woodward, Martin Ams, Darren D Hudson, Stuart D Jackson, Alex Fuerbach
We report the development of a widely tunable all-fiber mid-infrared laser system based on a mechanically robust fiber Bragg grating (FBG) which was inscribed through the polymer coating of a Ho3+-Pr3+ co-doped double clad ZBLAN fluoride fiber by focusing femtosecond laser pulses into the core of the fiber without the use of a phase mask. By applying mechanical tension and compression to the FBG while pumping the fiber with an 1150 nm laser diode, a continuous wave (CW) all-fiber laser with a tuning range of 37 nm, centered at 2870 nm, was demonstrated with up to 0...
November 27, 2017: Optics Express
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