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https://www.readbyqxmd.com/read/27904114/two-cases-of-proteinase-3-anti-neutrophil-cytoplasmic-antibody-pr3-anca-related-nephritis-in-infectious-endocarditis
#1
Kazuya Hirai, Naoto Miura, Masabumi Yoshino, Kanyu Miyamoto, Hironobu Nobata, Takuhito Nagai, Keisuke Suzuki, Shogo Banno, Hirokazu Imai
We herein report two cases of proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA)-related nephritis in infectious endocarditis. In both cases, the patients were middle-aged men with proteinuria and hematuria, hypoalbuminemia, decreased kidney function, anemia, elevated C-reactive protein (CRP) levels, and PR3-ANCA positivity. Each had bacteremia, due to Enterococcus faecium in one and Streptococcus bovis in the other. One patient received aortic valve replacement therapy for aortic regurgitation with vegetation, and the other underwent tricuspid valve replacement therapy and closure of a ventricular septic defect to treat tricuspid regurgitation with vegetation...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27902871/multicolor-tuning-in-room-temperature-self-activated-ca2nb2o7-submicroplates-by-lanthanide-doping
#2
Jun-Cheng Zhang, Yan-Jie Liu, Xu Yan, Hong-Di Zhang, Jun Zhang, Xiao-Xiong Wang, Wen-Peng Han, Yun-Ze Long, Xin-Yuan Sun
Self-activated phosphors are capable of generating optical emissions from the internal ion groups of host lattice before externally introducing luminescent ions. However, numerous self-activated phosphors only show luminescence at low temperature due to the thermally-activated energy migration among ion groups at room temperature, severely confining their application conditions. In this letter, we propose a strategy to converting the low-temperature luminescence to a room-temperature one through changing the synthesis conditions to induce structural distortions and thus to limit energy migration...
November 30, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27875995/high-throughput-gene-expression-quantification-of-grapevine-defense-responses-in-the-field-using-microfluidic-dynamic-arrays
#3
Marie-Cécile Dufour, Noël Magnin, Bernard Dumas, Sophie Vergnes, Marie-France Corio-Costet
BACKGROUND: The fight against grapevine diseases due to biotrophic pathogens usually requires the massive use of chemical fungicides with harmful environmental effects. An alternative strategy could be the use of compounds able to stimulate plant immune responses which significantly limit the development of pathogens in laboratory conditions. However, the efficiency of this strategy in natura is still insufficient to be included in pest management programs. To understand and to improve the mode of action of plant defense stimulators in the field, it is essential to develop reliable tools that describe the resistance status of the plant upon treatment...
November 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27862749/co6-h8-p-i-pr3-6-a-cobalt-octahedron-with-face-capping-hydrides
#4
Yasuhiro Ohki, Yuki Shimizu, Ryoichi Araake, Mizuki Tada, W M C Sameera, Jun-Ichi Ito, Hisao Nishiyama
A square-planar Co4 amide cluster, Co4 {N(SiMe3 )2 }4 (2), and an octahedral Co6 hydride cluster, Co6 H8 (P(i) Pr3 )6 (4), were obtained from metathesis-type amide to hydride exchange reactions of a Co(II) amide complex with pinacolborane (HBpin) in the absence/presence of P(i) Pr3 . The crystal structure of 4 revealed face-capping hydrides on each triangular [Co3 ] face, while the formal Co(II)2 Co(I)4 oxidation state of 4 indicated a reduction of the cobalt centers during the assembly process. Cluster 4 catalyzes the hydrosilylation of 2-cyclohexen-1-one favoring the conjugate reduction...
November 16, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27858870/simultaneous-comprehensive-multiplex-autoantibody-analysis-for-rapidly-progressive-glomerulonephritis
#5
Mandy Sowa, Barbara Trezzi, Rico Hiemann, Peter Schierack, Kai Grossmann, Juliane Scholz, Valentina Somma, Renato Alberto Sinico, Dirk Roggenbuck, Antonella Radice
Rapidly progressive glomerulonephritis (RPGN) is mainly caused by anti-glomerular basement membrane (GBM) antibody-mediated glomerulonephritis, immune-complex or anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides and leads to rapid loss of renal function. Detection of ANCA and autoantibodies (autoAbs) to GBM and dsDNA enables early diagnosis and appropriate treatment of RPGN aiding in preventing end-stage renal disease.Determination of ANCA on neutrophils (ANCA) as well as autoAbs to myeloperoxidase (MPO-ANCA), proteinase 3 (PR3-ANCA), GBM, and dsDNA was performed by the novel multiplex CytoBead technology combining cell- and microbead-based autoAb analyses by automated indirect immunofluorescence (IIF)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27824551/cocaine-induced-vasculitis
#6
REVIEW
Mark Berman, Daphna Paran, Ori Elkayam
The use of cocaine continues to grow worldwide. One of the possible side-effects of cocaine is vasculitis. Two distinct vasculitic syndromes have been described due to cocaine. One is cocaine-induced midline destructive lesion, secondary to a direct vasoconstrictor effect of cocaine, inducing ischemic necrosis of the septal cartilage and perforation of the nasal septum, mimicking findings of granulomatosis with polyangiitis in the upper airways. The other is ANCA-associated vasculitis, attributed to the levamisole component that contaminates about 70% of the cocaine...
October 31, 2016: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/27804864/immunology-rheumatology-approach-to-sudden-sensorineural-hearing-loss
#7
Mohsen Rajati, Massod Saghafi, Houshang Rafatpanah, Bashir Rasoulian, Shirin Irani, Mohammadsaleh Soltankhah
BACKGROUND: Sensorineural hearing loss (SNHL) and vestibular dysfunction have been described in various autoimmune disorders and systemic vasculitides. A high prevalence of SNHL is reported to occur in established rheumatologic diseases; however, immunologic and rheumatologic disorders make up a small proportion of patients with sudden sensorineural hearing loss (SSNHL). OBJECTIVE: This prospective study was carried out in order to determine the prevalence of rheumatologic and immunologic disorders in patients with SSNHL in Northeast Iran...
October 29, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27803133/comparison-of-the-phenotype-and-outcome-of-granulomatosis-with-polyangiitis-between-uk-and-japanese-cohorts
#8
Shunsuke Furuta, Afzal N Chaudhry, Yoshihiro Arimura, Hiroaki Dobashi, Shouichi Fujimoto, Sakae Homma, Niels Rasmussen, David R Jayne
OBJECTIVE: There are differences in the frequencies of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis subgroups between different geographic regions, and we have reported differences in the phenotype of microscopic polyangiitis between Europe and Japan. In this retrospective observational study, we compared phenotypes and outcomes of granulomatosis with polyangiitis (GPA) between the United Kingdom and Japan. METHODS: We identified 128 UK and 82 Japanese patients with GPA diagnosed between 2000 and 2012...
November 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27774563/a-pentacoordinated-norbornenyl-acyl-rhodium-iii-complex-as-a-likely-intermediate-in-the-catalytic-hydroacylation-of-norbornadiene
#9
N Almenara, L Ibarlucea, C Mendicute-Fierro, J M Seco, A Rodríguez-Diéguez, M A Garralda, M A Huertos
[RhCl(NCO)(nbyl)(PR3)] (nbyl = σ-norbornenyl; NCO = quinoline-8-acyl; R = p-F-C6H4) (1) has been synthesized by the reaction of [Rh(nbd)Cl]2 (nbd = norbornadiene) with 2 equivalents of NCHO (quinoline-8-carbaldehyde) and 2 equivalents of PR3. Compound 1 has been fully characterized in solution and also in the solid state by X-ray diffraction. Compound 1 shows low stability in solution and undergoes slow ring closure isomerization to [RhCl(NCO)(ntyl)(PR3)] (ntyl = σ-nortricyclyl) (2) after 12 hours. Reaction of 1 with an extra equivalent of aldehyde (NCHO) and PR3 led to the formation of [RhCl(H)(NCO)(PR3)2] (3) and an equivalent of ketone, which is a hydroacylation product...
October 24, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27773081/comparison-of-enzyme-linked-immunosorbent-assay-elisa-with-bio-flash-rapid-response-chemiluminescent-analyser-bfrrca-in-the-detection-of-myeloperoxidase-mpo-and-proteinase-3-pr3-antibodies
#10
Phillippa A Pucar, Carolyn Hawkins, Katrina L Randall, Candice Li, Euan McNaughton, Matthew Cook
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27755585/microrna-941-expression-in-polymorphonuclear-granulocytes-is-not-related-to-granulomatosis-with-polyangiitis
#11
Jesper Brink Svendsen, Bo Baslund, Elisabeth Præstekjær Cramer, Nicolas Rapin, Niels Borregaard, Jack Bernard Cowland
Jumonji Domain-Containing Protein 3 (JMJD3)/lysine demethylase 6B (KDM6B) is an epigenetic modulator that removes repressive histone marks on genes. Expression of KDM6B mRNA is elevated in leukocytes from patients with ANCA-associated vasculitis (AAV) and has been suggested to be the reason for higher proteinase 3 (PR3) mRNA expression in these cells due to derepression of PRTN3 gene transcription. MicroRNA-941 (miR-941) has been shown to target KDM6B mRNA and inhibit JMJD3 production. We therefore investigated whether polymorphonuclear granulocytes (PMNs) from patients suffering from granulomatosis with polyangiitis (GPA) have lower expression of miR-941 than healthy control donors as a biological cause for higher JMJD3 levels...
2016: PloS One
https://www.readbyqxmd.com/read/27752292/histone-modification-signature-at-myeloperoxidase-and-proteinase-3-in-patients-with-anti-neutrophil-cytoplasmic-autoantibody-associated-vasculitis
#12
Jiajin Yang, Heng Ge, Caroline J Poulton, Susan L Hogan, Yichun Hu, Britta E Jones, Candace D Henderson, Elizabeth A McInnis, William F Pendergraft, J Charles Jennette, Ronald J Falk, Dominic J Ciavatta
BACKGROUND: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease characterized by destructive vascular inflammation. Two prominent ANCA autoantigens are myeloperoxidase (MPO) and proteinase 3 (PR3), and transcription of MPO and PRTN3, the genes encoding the autoantigens, is associated with disease activity. We investigated whether patients with AAV have alterations in histone modifications, particularly those associated with transcriptional activation, at MPO and PRTN3...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27749588/diagnosing-anca-associated-vasculitis-in-anca-positive-patients-a-retrospective-analysis-on-the-role-of-clinical-symptoms-and-the-anca-titre
#13
Eline Houben, Willem A Bax, Bastiaan van Dam, Walentina A T Slieker, Gideon Verhave, Fenneke C P Frerichs, Izhar C van Eijk, Wim G Boersma, Guido T M de Kuyper, Erik L Penne
Currently no validated diagnostic system for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is available. Therefore, diagnosing AAV is often challenging. We aimed to identify factors that lead to a clinical diagnosis AAV in ANCA positive patients in a teaching hospital in The Netherlands.In this study, all patients that tested positive for ANCA proteinase 3 (PR3) and/or myeloperoxidase (MPO) between 2005 and 2015 were analysed. Patients with a clinical diagnosis of AAV were compared with patients without a clinical diagnosis of AAV...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27746996/video-assisted-thoracoscopic-lobectomy-which-is-the-learning-curve-of-an-experienced-consultant
#14
Antonio Mazzella, Anne Olland, Pierre Emmanuel Falcoz, Stephane Renaud, Nicola Santelmo, Gilbert Massard
BACKGROUND: This study evaluates the number of video-assisted thoracic surgery-lobectomies (VATS-lobectomies) required for an experienced consultant thoracic surgeon to obtain competence and to perform standard quality surgery. METHODS: We have analysed the initial VATS-experience (January 2012 to September 2014) of a confirmed senior consultant who has performed 145 consecutive anatomic resections by thoracoscopy. After excluding bilobectomies, segmentectomies, and lobectomies for infectious disease, we have focused into 119 consecutive lobectomies, classified into 4 chronologic groups of 30 each...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27746439/rapidly-progressive-renal-dysfunction-in-two-elderly-patients-with-renal-enlargement-and-medullary-cystic-kidney-disease-like-acute-tubulointerstitial-injury
#15
Shinya Kawamoto, Ryo Koda, Atsunori Yoshino, Tetsuro Takeda, Yoshihiko Ueda
Medullary cystic kidney disease (MCKD) is a hereditary disease associated with bilateral medullary polycysts and interstitial fibrosis. MCKD is typically associated with slowly progressive renal dysfunction. We herein report two rare elderly cases with enlarged kidneys and rapidly progressive renal dysfunction without myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA), PR3-ANCA, or anti-glomerular basement membrane (GBM) antibodies. Renal biopsies revealed extensive tubular dilatation and atrophy with interstitial fibrosis consistent with MCKD...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27741122/possibly-propylthiouracil-induced-antineutrophilic-cytoplasmic-antibody-associated-vasculitis-manifested-as-blood-coagulation-disorders-a-case-report
#16
Xiao-Yan Yi, Yao Wang, Qi-Fu Li, Rong Li, Shu-Min Yang, Guo-Qing Zhou, Zhi-Hong Wang
BACKGROUND: Propylthiouracil is the most common drug used to treat hyperthyroidism. However, this drug could cause a severe disease, antineutrophilic cytoplasmic antibody-associated vasculitis (AAV), which was usually misdiagnosed. METHODS: We reported a 60-year-old woman of propylthiouracil-induced AAV manifested as blood coagulation disorders. The patient was admitted because of hyperthyroidism and leukopenia. At the time of hospitalization, she suffered from dry cough, erythema and knee joints ache, and gradually became febrile...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27733943/updates-in-anca-associated-vasculitis
#17
Christian Pagnoux
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are small-vessel vasculitides that include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Renal-limited ANCA-associated vasculitides can be considered the fourth entity. Despite their rarity and still unknown cause(s), research pertaining to ANCA-associated vasculitides has been very active over the past decades. The pathogenic role of antimyeloperoxidase ANCA (MPO-ANCA) has been supported using several animal models, but that of antiproteinase 3 ANCA (PR3-ANCA) has not been as strongly demonstrated...
September 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27701801/aromatic-osmacyclopropenefuran-bicycles-and-their-relevance-for-the-metal-mediated-hydration-of-functionalized-allenes
#18
María Batuecas, Ruth Castro-Rodrigo, Miguel A Esteruelas, Cristina García-Yebra, Ana M López, Enrique Oñate
The aromatic osmacyclopropenefuran bicycles [OsTp{κ(3) -C(1) ,C(2) ,O-(C(1) H2 C(2) CHC(OEt)O)}(P(i) Pr3 )]BF4 (Tp=hydridotris(1-pyrazolyl)borate) and [OsH{κ(3) -C(1) ,C(2) ,O-(C(1) H2 C(2) CHC(OEt)O)}(CO)(P(i) Pr3 )2 ]BF4 , with the metal fragment in a common vertex between the fused three- and five-membered rings, have been prepared via the π-allene intermediates [OsTp(η(2) -CH2 =CCHCO2 Et)(OCMe2 )(P(i) Pr3 )]BF4 and [OsH(η(2) -CH2 =CCHCO2 Et)(CO)(OH2 )(P(i) Pr3 )2 ]BF4 , and their aromaticity analyzed by DFT calculations...
October 24, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27699023/elevated-serum-levels-of-two-anti-neutrophil-cytoplasmic-antibodies-in-a-lung-cancer-patient-a-case-report
#19
Shinichiro Okauchi, Tomohiro Tamura, Katsunori Kagohashi, Mio Kawaguchi, Hiroaki Satoh
A 71-year-old woman with arthralgia and lung fibrosis was referred to Mito Kyodo General Hospital (Mito, Japan) for a mass, which was incidentally observed on a chest radiograph. The chest computed tomography scan demonstrated fibrotic lesions in the lower lobes of the lung and a nodule in the left upper lobe. The serum levels of myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA) and proteinase 3 (PR3)-ANCA were 60.3 and 7.5 U/ml, respectively. A transbronchial biopsy obtained from the nodule in the left upper lobe of the lung revealed a lung adenocarcinoma and the patient underwent standard upper lobectomy of the left lung...
October 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27689755/different-forms-of-alpha-1-antitrypsin-and-neutrophil-activation-mediated-by-human-anti-pr3-igg-antibodies
#20
Marcin Surmiak, Marek Sanak
BACKGROUND: One of characteristic findings in granulomatosis with polyangiitis (GPA) is the presence of proteinase-3 (anti-PR3) specific antibodies. These antibodies can cause neutrophil activation, degranulation and generation of reactive oxygen species (ROS). Each of these inflammatory events can be suppressed by circulating alpha-1 antitrypsin (A1AT). A1AT is an acute phase protein increasing during inflammation, however, it may circulate as an inactive polymeric protein. AIM OF THE STUDY: The aim was to analyze how different types of A1AT can affect anti-PR3 mediated neutrophil activation...
August 5, 2016: Pharmacological Reports: PR
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