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https://www.readbyqxmd.com/read/29772695/botulinum-toxin-type-a-injection-for-cervical-dystonia-in-adults-with-dyskinetic-cerebral-palsy
#1
You Gyoung Yi, Keewon Kim, Youbin Yi, Young-Ah Choi, Ja-Ho Leigh, Moon Suk Bang
We aimed to evaluate the efficacy and safety of injecting botulinum toxin A (BoNT-A) into the neck muscles to treat cervical dystonia (CD) in patients with dyskinetic cerebral palsy (CP). This was a randomized, double-blinded, placebo-controlled trial with cross-over design. We prospectively enrolled adults with dyskinetic CP who were over 20 years old and had been clinically diagnosed with CD for more than one year. The primary outcome measure was the change in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) at four weeks from the baseline TWSTRS...
May 16, 2018: Toxins
https://www.readbyqxmd.com/read/29744614/a-case-of-epidural-glioblastoma-metastasis-presenting-with-a-cervical-myelopathy-torticollis-and-l-hermitte-s-phenomenon
#2
Michael W Ruff, Adip G Bhargav, Aditya Raghunathan
Extraneural glioblastoma metastases are exceedingly rare, though previously described in the literature. Activating mutations in the BRAF kinase gene (V600E) are present in a minority of glioblastoma patients. Here, we describe a case of systemic metastases of a clonal subpopulation of BRAF V600E mutated glioblastoma in a patient previously treated with surgery, radiation, temozolomide and bevacizumab. The patient presented with a subacute cervical myelopathy during adjuvant treatment. He underwent emergent surgical decompression of an epidural spine metastasis...
May 9, 2018: Brain Tumor Pathology
https://www.readbyqxmd.com/read/29731316/the-grisel-s-syndrome-a-non-traumatic-subluxation-of-the-atlantoaxial-joint
#3
L Fath, H Cebula, M N Santin, A Coca, C Debry, F Proust
INTRODUCTION: Grisel's syndrome consists in rotational subluxation of C1-C2 following ENT infection or surgery. There is no consensus on management. We present 2 cases requiring surgical treatment in our center. CASE REPORTS: Two 10-year-old patients presented torticollis with cervical pain resistant to medical treatment, with onset a few months after tonsillectomy. In both cases, radiological assessment, comprising CT scan and MRI, showed Fielding-Hawkins type-3 C1-C2 rotational subluxation, without ligament lesion...
May 3, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29720210/endoscopic-release-of-congenital-muscular-torticollis-with-radiofrequency-in-teenagers
#4
Jun-Liang Wang, Wei Qi, Yu-Jie Liu
BACKGROUND: Congenital muscular torticollis (CMT) is due to contracture of the sternocleidomastoid muscle which may cause activity limitations of the neck, tilt of the head, craniofacial asymmetry, and deformity of the skull. The authors present their experience of arthroscopic tight fibrous band release with radiofrequency in teenagers under local anesthesia and evaluate the clinical results. METHODS: A total of 69 patients who underwent arthroscopic release of CMT with radiofrequency under local anesthesia by a single surgeon could participate in this study...
May 3, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29678707/long-term-clinical-and-radiological-postoperative-outcomes-after-c1-c2-pedicle-screw-techniques-for-pediatric-atlantoaxial-rotatory-dislocation
#5
Xinjie Wu, Yafeng Li, Mingsheng Tan, Ping Yi, Feng Yang, Xiangsheng Tang, Qingying Hao
BACKGROUND: Although C1-C2 pedicle screw techniques have been extensively reported in paediatric series, reports on their use have examined only small series with short follow-up periods. Here, we present a study on paediatric patients with atlantoaxial rotatory dislocation (AARD) treated with these techniques with a minimum 5-year follow-up period. METHODS: A total of 27 paediatric patients with AARD who underwent C1-C2 pedicle screw fixation between 2004 and 2012 were retrospectively evaluated...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29671179/clinical-infection-in-house-rats-rattus-rattus-caused-by-streptobacillus-notomytis
#6
Viktoria Michel, Claudia Ulber, Dietrich Pöhle, Beate Köpke, Katharina Engel, Ute Kaim, Ahmad Fawzy, Sophie Funk, Juliane Fornefett, Christoph Georg Baums, Tobias Eisenberg
Rat bite fever is an under-reported, under-diagnosed emerging zoonosis with worldwide distribution. Besides Spirillum minus, Streptobacillus moniliformis is the major causative microorganism although it usually colonises rats without any clinical signs. A group of house rats (Rattus rattus) kept in a zoo exhibition for educational purposes suffered from neurological signs including disorientation, torticollis, stall walking, ataxia and death. Gross pathological and histo-pathological examinations of the investigated rats revealed high-grade otitis interna et media, from which Streptobacillus notomytis was isolated in pure culture or as the predominant microorganism...
April 18, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29670567/gaba-a-receptor-availability-changes-underlie-symptoms-in-isolated-cervical-dystonia
#7
Brian D Berman, Rebecca Tran Pollard, Erika Shelton, Ramesh Karki, Peter M Smith-Jones, Yubin Miao
GABAA receptor availability changes within sensorimotor regions have been reported in some isolated forms of dystonia. Whether similar abnormalities underlie symptoms in cervical dystonia is not known. In the present study, a total of 15 cervical dystonia patients and 15 age- and sex-matched controls underwent 11 C-flumazenil PET/CT scanning. The density of available GABAA receptors was estimated using a Simplified Reference Tissue Model 2. Group differences were evaluated using a two-sample T -test, and correlations with dystonia severity, as measured by the Toronto Western Spasmodic Torticollis Rating Scale, and disease duration were evaluated using a regression analysis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29656928/benign-paroxysmal-migraine-variants-of-infancy-and-childhood-transitions-and-clinical-features
#8
Jacob Brodsky, Karampreet Kaur, Talia Shoshany, Sophie Lipson, Guangwei Zhou
INTRODUCTION: Migraine variant disorders of childhood include benign paroxysmal torticollis of infancy (BPTI) and benign paroxysmal vertigo of childhood (BPVC). This study aimed to review our experience with BPTI and BPVC and determine the incidence of children transitioning between each of these disorders and to vestibular migraine (VM). METHODS: We retrospectively reviewed the medical records of patients seen at the Balance and Vestibular Program at Boston Children's Hospital between January 2012 and December 2016 who were diagnosed with BPTI, BPVC, and/or VM...
March 30, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29608485/new-rhizotomy-procedure-for-primary-spasmodic-torticollis
#9
Chunhui Hua, Benfang Pu, Kaizhang Liu, Zhenyu Huang, Changhua Li, Changyi Zhao, Xinyuan Li
OBJECTIVE: Spasmodic torticollis (ST) is an idiopathic neurologic disorder affecting the muscles of the neck. Surgery is a preferred treatment, when conservative treatments or Botulinum neurotoxin injections fail to relieve the symptoms. Our objective here is to report the outcome of a new surgical method for treating ST patients in our department. METHODS: The new procedure consists of rhizotomy of the spinal accessory nerve (SAN) and C1-C2 nerve roots, coagulation of the distal end of SAN (Group A)...
March 30, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29607887/pilot-study-of-a-device-to-induce-the-hanger-reflex-in-patients-with-cervical-dystonia
#10
Takashi Asahi, Michi Sato, Takuto Nakamura, Yuki Kon, Hiroyuki Kajimoto, Genko Oyama, Akito Hayashi, Kazunori Tanaka, Shunya Nakane, Takao Takeshima, Masami Fujii, Satoshi Kuroda
The hanger reflex (HR) is an involuntary head rotation that occurs in response to a clothes hanger encircling the head and compressing the unilateral fronto-temporal area. Here, we developed an elliptical device to induce the HR and examined its utility for the treatment of cervical dystonia (CD). The study included 19 patients with rotational-type CD. The device was applied to each subject's head for at least 30 min/day for 3 months. Severity scores on part 1 of the Toronto Western Spasmodic Torticollis Rating Scale were evaluated at baseline and after the 3-month trial...
March 31, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29601304/episodic-syndromes-of-childhood-associated-with-migraine
#11
Amy A Gelfand
PURPOSE OF REVIEW: This review covers recent advances in our understanding of episodic syndromes that may be associated with migraine in children and adolescents, as well as what is known about the treatment of these disorders. RECENT FINDINGS: The episodic syndromes include benign paroxysmal torticollis, benign paroxysmal vertigo, abdominal migraine, and cyclic vomiting syndrome. Infant colic, or excessive crying in an otherwise healthy and well fed infant, may also fit into this category and is included in the appendix section of the most recent edition of the International Classification of Headache Disorders...
March 29, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29599004/pathology-and-distribution-of-velogenic-viscerotropic-newcastle-disease-virus-in-the-reproductive-system-of-vaccinated-and-unvaccinated-laying-hens-gallus-gallus-domesticus-by-immunohistochemical-labelling
#12
A O Igwe, C L Afonso, W S Ezema, C C Brown, J O A Okoye
This study investigated the pathological changes in the reproductive system of laying hens that lead to the poor egg production and quality in Newcastle disease (ND) and the distribution of the virus in the system. Two hundred and forty Isa-Brown pullets were divided randomly into vaccinated and unvaccinated groups (n = 120 each). The vaccinated group was given Hitchner B1 vaccine at 1 day of age, La Sota vaccine at 4 weeks of age and Komarov vaccine at 9 and 16 weeks of age. At the peak of egg production, the laying hens (32 weeks old) were assigned randomly into four groups (n = 60): VC, vaccinated with ND vaccines and inoculated intramuscularly with velogenic viscerotropic ND virus (vvNDV); VU, vaccinated unchallenged; UC, unvaccinated challenged; and UU, unvaccinated unchallenged...
February 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29595654/traumatic-c1-2-rotatory-subluxation-with-dens-and-bilateral-articular-facet-fractures-of-c2-a-case-report
#13
Dong-Gune Chang, Jong-Beom Park, Hyuk-Jin Jang
RATIONALE: To the best of our knowledge, this is an extremely rare case of traumatic C1-2 rotatory subluxation associated with multiple C2 fractures. PATIENT CONCERNS: We report the case of a 63-year-old man with type 2 traumatic C1-2 rotatory subluxation (Fielding and Hawkins classification) associated with type III dens (Anderson and D'Alonzo classification) and bilateral articular facet fractures of C2. This injury occurred as a result of falling down in a drunken state...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29560341/rare-concurrence-of-congenital-muscular-torticollis-and-a-malignant-tumor-in-the-same-sternocleidomastoid-muscle
#14
Yul-Hyun Park, Chul-Ho Kim, Jang-Hee Kim, Jun-Eun Park, Shin-Young Yim
While congenital muscular torticollis (CMT) can occur along with other conditions, such as clavicle fracture or brachial plexus injury, these conditions exist outside the sternocleidomastoid muscle (SCM). We present a rare case with concurrence of CMT and a malignant tumor inside the same SCM, along with serial clinical and radiological findings of the atypical features of CMT. The malignant tumor was in fact a low-grade fibromyxoid sarcoma. To the best of our knowledge, the current case is the first of a concurrent condition of CMT inside the SCM...
February 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29557988/personalized-botulinum-toxin-type-a-therapy-for-cervical-dystonia-based-on-kinematic-guidance
#15
Olivia Samotus, Jack Lee, Mandar Jog
BACKGROUND: Botulinum toxin type A (BoNT-A) injections is the accepted first-line therapy for cervical dystonia (CD), however, numerous patients discontinue treatment early due to perceived sub-optimal relief. To improve BoNT-A therapy for CD, proper assessment of neck motion and selection of relevant muscles and dosing must be met. Kinematic technology may improve treatment outcomes by guiding physicians to better tailor muscle selection and BoNT-A dosing for CD therapy. METHODS: 28 CD participants were placed into either group: expert injector determined injection patterns by visual assessment ("vb") versus injection patterns based on kinematics interpreted by an expert injector ("kb")...
March 20, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29544873/primary-ewing-sarcoma-of-the-axis-c2-a-case-report-and-the-review-of-the-literature
#16
Kyriakos Paraskeva, Dimitrios Giakoumettis, Ioannis Nikas, George Georgoulis, George Sfakianos, Marios S Themistocleous
INTRODUCTION: Neck pain and torticollis are common symptoms in the pediatric population that rarely requires further investigation. However, in case symptoms persist, then a more meticulously approach should be considered. Underlying conditions such as infections, neck injury, autoimmune disorders or even cervical spine cancer should be excluded from diagnosis. Cervical spine cancer is a rare neurosurgical entity in the pediatric population and even rarer is atlantoaxial Ewing's sarcoma...
March 3, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29541052/relationships-between-serotonin-transporter-binding-in-the-raphe-nuclei-basal-ganglia-and-hippocampus-with-clinical-symptoms-in-cervical-dystonia-a-11-c-dasb-positron-emission-tomography-study
#17
Marenka Smit, David Vállez García, Bauke M de Jong, Evelien Zoons, Jan Booij, Rudi A Dierckx, Antoon T Willemsen, Erik F de Vries, Anna L Bartels, Marina A Tijssen
Purpose: Alterations of the central serotonergic system have been implicated in the pathophysiology of dystonia. In this molecular imaging study, we assessed whether altered presynaptic serotonin transporter (SERT) binding contributes to the pathophysiology of cervical dystonia (CD), concerning both motor and non-motor symptoms (NMS). Methods: We assessed the non-displaceable binding potential (BPND ) using the selective SERT tracer [11 C]DASB and positron emission tomography (PET) in 14 CD patients and 12 age- and gender-matched controls...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29530726/minimal-clinically-important-change-in-the-toronto-western-spasmodic-torticollis-rating-scale
#18
Alberto J Espay, Richard Trosch, Gustavo Suarez, Jonathan Johnson, Dominic Marchese, Cynthia Comella
OBJECTIVES: To characterize the minimal clinically important change (MCIC) after treatment in cervical dystonia patients using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). METHODS: Changes in the TWSTRS from an observational study of abobotulinumtoxinA in the routine management of cervical dystonia (NCT01314365) were analyzed using the Patient Global Impression of Change (PGIC) as anchor. RESULTS: For the overall population (N = 304, baseline TWSTRS-Total score 43...
March 7, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29517619/sandifer-syndrome
#19
Debora M Moore, Denise Rizzolo
Sandifer syndrome is a rare complication of gastroesophageal reflux disease that may be more common than reported. This syndrome was first mentioned more than 50 years ago with minimal documentation in the medical literature. Because of the presentation, the patient may be referred for lengthy, expensive, and unnecessary neurologic testing. This may lead to a missed or delayed diagnosis, mismanagement, and the use of inappropriate medication. Providers should be aware of Sandifer syndrome when evaluating a child with torticollis or unusual posturing that is not associated with neuromuscular disease or injury...
March 6, 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29496687/painful-torticollis-following-adenotonsillectomy-a-cardinal-sign-of-atlantoaxial-subluxation
#20
Benjamin John Miller, Raj Lakhani, Arif Rashid, Philipa Tostevin
An 11-year-old boy with a history of autism spectrum disorder attended the emergency department with his mother 8 days after an adenotonsillectomy reporting postoperative bleeding. Detailed physical examination revealed no active bleeding, but a rigid neck posture was noted. A head and neck CT scan demonstrated unilateral rotatory atlantoaxial subluxation and possible damage to the anterior spinal ligament. He was reviewed by neurosurgeons who performed manipulation under anaesthetic and successfully realigned the occipital cervical tract...
March 1, 2018: BMJ Case Reports
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