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https://www.readbyqxmd.com/read/28937236/impact-of-early-aggressive-nutrition-on-retinal-development-in-premature-infants
#1
N Lenhartova, K Matasova, Z Lasabova, K Javorka, A Calkovska
The normal retinal development is interrupted by preterm birth and a retinopathy of prematurity (ROP) may develop as its consequence. ROP is characterized by aberrant vessel formation in the retina as a response to multiple risk factors influencing the process of retinal angiogenesis. Insulin-like growth factor I (IGF-1) and vascular endothelial growth factor (VEGF) play an important role in the process of normal retinal vascularization. Insufficient nutrition during the first 4 postnatal weeks results in low serum levels of IGF-1, which is essential for correct retinal vessels formation, ensuring survival of the newly formed endothelial cells...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28937056/serum-cystatin-c-as-an-earlier-predictor-of-acute-kidney-injury-than-serum-creatinine-in-preterm-neonates-with-respiratory-distress-syndrome
#2
Noha Ahmed Abdelaal, Sherein Abdelhamid Shalaby, Abdelmoneim Kassem Khashana, Amina Mohamed Abdelwahab
In this study, we aimed to evaluate serum cystatin C (sCysC) as an early predictor of acute kidney injury (AKI) in preterm neonates with respiratory distress syndrome (RDS). Sixty preterm neonates diagnosed with RDS and 40 healthy controls (28-36 weeks) admitted to the neonatal Intensive Care Unit were investigated. AKI was defined on the 3rd day of life (DOL-3) as an increase in serum creatinine (sCr) of >0.3 mg/dL from baseline (the lowest previous sCr). sCysC levels were measured on DOL-1, -3 and -7. Of the 60 neonates with RDS, 24 (40%) developed AKI...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28936902/maternal-obesity-is-associated-with-chorioamnionitis-and-earlier-indicated-preterm-delivery-among-expectantly-managed-women-with-preterm-premature-rupture-of-membranes
#3
Emily E Hadley, Andrea Discacciati, Maged M Costantine, Mary B Munn, Luis D Pacheco, George R Saade, Giuseppe Chiossi
OBJECTIVE: To determine the association between maternal obesity and delivery due to chorioamnionitis prior to labor onset, among expectantly managed women with preterm premature rupture of membranes (pPROM). METHODS: This was a secondary analysis of a multicenter randomized trial of magnesium sulfate versus placebo to prevent cerebral palsy or death among offspring of women with anticipated delivery at 24-31-week gestation. After univariable analysis, Cox proportional hazard evaluated the association between maternal obesity and chorioamnionitis, while Laplace regression investigated how obesity affects the gestational age at delivery of the first 20% of women developing the outcome of interest...
September 22, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28934940/human-development-index-hdi-of-the-maternal-country-of-origin-as-a-predictor-of-perinatal-outcomes-a-longitudinal-study-conducted-in-spain
#4
S Garcia-Tizon Larroca, J Arevalo-Serrano, A Duran Vila, M P Pintado Recarte, I Cueto Hernandez, A Solis Pierna, S Lizarraga Bonelli, J De Leon-Luis
BACKGROUND: In an era of worldwide population displacement, recent studies have identified strong associations between social situations and perinatal outcomes among immigrants. Little is known about the effect of maternal social background on pregnancy outcomes. The Human Development Index (HDI) assesses the following dimensions of human development: life expectancy, education level and income. The objective of our study was to determine if maternal HDI may be used to identify women at increased odds of poor pregnancy outcomes...
September 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28934915/-significant-intraventricular-hemorrhage-is-more-likely-in-very-preterm-infants-born-by-vaginal-delivery-a-multi-centre-retrospective-cohort-study
#5
Islam Gamaleldin, David Harding, Dimitrios Siassakos, Tim Draycott, David Odd
OBJECTIVES: To determine the association between mode of delivery (vaginal delivery [VD] versus cesarean section [CS]) and the rate of significant intraventricular hemorrhage (sIVH) in preterm infants. METHODS: A multicenter retrospective cohort study, based on data collected from the Vermont Oxford Network database. Infants born between 23 and 31(+6) weeks of gestational age between 2001 and 2014 were identified. Exposure was the mode of birth (VD versus CS). Primary outcome was development of sIVH...
September 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28934743/early-electroencephalography-suppression-and-postnatal-morbidities-correlate-with-cerebral-volume-at-term-equivalent-age-in-very-preterm-infants
#6
Sverre Wikström, Holger Hövel, Ingrid Hansen Pupp, Vineta Fellman, Petra S Hüppi, David Ley, Lena Hellström-Westas
BACKGROUND: Early brain activity is associated with long-term outcome. Establishing a relation also with postnatal brain growth may increase our understanding of early life influences on preterm brain development. OBJECTIVES: The aim of this study was to investigate whether early electroencephalography (EEG) activity in infants born very preterm is associated with brain volumes at term, and whether postnatal morbidity affects this association. METHODS: Very preterm infants (n = 38) with a median gestational age (GA) of 25...
September 22, 2017: Neonatology
https://www.readbyqxmd.com/read/28933776/association-of-nursing-overtime-nurse-staffing-and-unit-occupancy-with-medical-incidents-and-outcomes-of-very-preterm-infants
#7
M Beltempo, G Lacroix, M Cabot, R Blais, B Piedboeuf
OBJECTIVE: To examine the association of nursing overtime, nursing provision and unit occupancy rate with medical incident rates in the neonatal intensive care unit (NICU) and the risk of mortality or major morbidity among very preterm infants. STUDY DESIGN: Single center retrospective cohort study of infants born within 23 to 29 weeks of gestational age or birth weight <1000 g admitted at a 56 bed, level III NICU. Nursing overtime ratios (nursing overtime hours/total nursing hours), nursing provision ratios (nursing hours/recommended nursing hours based on patient dependency categories) and unit occupancy rates were pooled for all shifts during NICU hospitalization of each infant...
September 21, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28931047/association-between-perinatal-hypoxic-ischemia-and-periventricular-leukomalacia-in-preterm-infants-a-systematic-review-and-meta-analysis
#8
Jichong Huang, Li Zhang, Bingyao Kang, Tingting Zhu, Yafei Li, Fengyan Zhao, Yi Qu, Dezhi Mu
BACKGROUND: Although investigators have implicated hypoxic-ischemia (HI) as a potential cause of periventricular leukomalacia (PVL), the role of clinical risk factors or markers for HI in the development of PVL remains controversial. The aim of this study was to identify perinatal HI-related factors associated with PVL. METHOD: The PubMed, EMBASE, and Cochrane Library databases were searched. The last search was performed on January 2017. Summary effect estimates (pooled odds ratios [ORs]) were calculated for each risk factor using fixed or random effects models with tests for heterogeneity and publication bias...
2017: PloS One
https://www.readbyqxmd.com/read/28929094/gestational-age-dependent-increase-of-survival-motor-neuron-protein-in-umbilical-cord-derived-mesenchymal-stem-cells
#9
Sota Iwatani, Nur Imma Fatimah Harahap, Dian Kesumapramudya Nurputra, Shinya Tairaku, Akemi Shono, Daisuke Kurokawa, Keiji Yamana, Khin Kyae Mon Thwin, Makiko Yoshida, Masami Mizobuchi, Tsubasa Koda, Kazumichi Fujioka, Mariko Taniguchi-Ikeda, Hideto Yamada, Ichiro Morioka, Kazumoto Iijima, Hisahide Nishio, Noriyuki Nishimura
BACKGROUND: Spinal muscular atrophy (SMA) is the most common genetic neurological disease leading to infant death. It is caused by loss of survival motor neuron (SMN) 1 gene and subsequent reduction of SMN protein in motor neurons. Because SMN is ubiquitously expressed and functionally linked to general RNA metabolism pathway, fibroblasts (FBs) are most widely used for the assessment of SMN expression in SMA patients but usually isolated from skin biopsy samples after the onset of overt symptoms...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28927754/motility-disorders-in-infants
#10
I J N Koppen, M A Benninga, M M J Singendonk
Gastrointestinal motility disorders are common in the pediatric population and may affect the entire gastrointestinal tract and can vary from mild to severe conditions. They may clinically manifest as gastro-esophageal reflux symptoms, feeding difficulties and failure to thrive, constipation and diarrhea amongst others. This review first highlights the embryologic development of the gastrointestinal tract, after which the prenatal and neonatal development of gastrointestinal motility is discussed. Normal motility patterns as seen in (preterm) infants are described as a background for the discussion of the most common congenital and acquired motility disorders in infancy...
September 16, 2017: Early Human Development
https://www.readbyqxmd.com/read/28926371/residential-agricultural-pesticide-exposures-and-risks-of-spontaneous-preterm-birth
#11
Gary M Shaw, Wei Yang, Eric M Roberts, Susan E Kegley, David K Stevenson, Suzan L Carmichael, Paul B English
BACKGROUND: Pesticides exposures are aspects of the human exposome that have not been sufficiently studied for their contribution to risk for preterm birth. We investigated risks of spontaneous preterm birth from potential residential exposures to 543 individual chemicals and 69 physicochemical groupings that were applied in the San Joaquin Valley of California during the study period, 1998-2011. METHODS: The study population was derived from birth certificate data linked with Office of Statewide Health Planning and Development maternal and infant hospital discharge data...
September 18, 2017: Epidemiology
https://www.readbyqxmd.com/read/28925893/big-data-analyses-for-continuous-evaluation-of-pharmacotherapy-a-proof-of-principle-with-doxapram-in-preterm-infants
#12
Robert Flint, Willem van Weteringen, Swantje Völler, Jarinda A Poppe, Birgit Cp Koch, Ronald de Groot, Dick Tibboel, Catherijne Aj Knibbe, Irwin Km Reiss, Sinno Hp Simons
BACKGROUND: Drug effect evaluation is often based on subjective interpretation of a selection of patient data. Continuous analyses of high frequency patient monitor data are a valuable source to measure drug effects. However, these have not yet been fully explored in clinical care. We aim to evaluate the usefulness and applicability of high frequency physiological data for analyses of pharmacotherapy. METHODS: As a proof of principle, the effects of doxapram, a respiratory stimulant, on the oxygenation in preterm infants were studied...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28925578/combined-fetal-inflammation-and-postnatal-hypoxia-causes-myelin-deficits-and-autism-like-behavior-in-a-rat-model-of-diffuse-white-matter-injury
#13
Erik van Tilborg, E J Marijke Achterberg, Caren M van Kammen, Annette van der Toorn, Floris Groenendaal, Rick M Dijkhuizen, Cobi J Heijnen, Louk J M J Vanderschuren, Manon N J L Benders, Cora H A Nijboer
Diffuse white matter injury (WMI) is a serious problem in extremely preterm infants, and is associated with adverse neurodevelopmental outcome, including cognitive impairments and an increased risk of autism-spectrum disorders. Important risk factors include fetal or perinatal inflammatory insults and fluctuating cerebral oxygenation. However, the exact mechanisms underlying diffuse WMI are not fully understood and no treatment options are currently available. The use of clinically relevant animal models is crucial to advance knowledge on the pathophysiology of diffuse WMI, allowing the definition of novel therapeutic targets...
September 19, 2017: Glia
https://www.readbyqxmd.com/read/28925538/maternal-intelligence-quotient-iq-predicts-iq-and-language-in-very-preterm-children-at-age-5%C3%A2-years
#14
Rachel E Lean, Rachel A Paul, Christopher D Smyser, Cynthia E Rogers
BACKGROUND: Sociodemographic factors are linked to cognitive outcomes in children born very preterm (VPT; ≤30 weeks gestation). The influence of maternal intellectual ability, a heritable trait, is unknown. Also undetermined is the extent to which associations between maternal and child intellectual ability vary according to parenting behaviors that target cognitive stimulation in the home. METHODS: At age 5 years, 84 VPT and 38 demographically matched full-term (FT) children underwent neurodevelopmental assessment...
September 19, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28923828/attenuated-pdgf-signaling-drives-alveolar-and-microvascular-defects-in-neonatal-chronic-lung%C3%A2-disease
#15
Prajakta Oak, Tina Pritzke, Isabella Thiel, Markus Koschlig, Daphne S Mous, Anita Windhorst, Noopur Jain, Oliver Eickelberg, Kai Foerster, Andreas Schulze, Wolfgang Goepel, Tobias Reicherzer, Harald Ehrhardt, Robbert J Rottier, Peter Ahnert, Ludwig Gortner, Tushar J Desai, Anne Hilgendorff
Neonatal chronic lung disease (nCLD) affects a significant number of neonates receiving mechanical ventilation with oxygen-rich gas (MV-O2). Regardless, the primary molecular driver of the disease remains elusive. We discover significant enrichment for SNPs in the PDGF-Rα gene in preterms with nCLD and directly test the effect of PDGF-Rα haploinsufficiency on the development of nCLD using a preclinical mouse model of MV-O2 In the context of MV-O2, attenuated PDGF signaling independently contributes to defective septation and endothelial cell apoptosis stemming from a PDGF-Rα-dependent reduction in lung VEGF-A...
September 18, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28923474/beyond-the-inhaled-nitric-oxide-in-persistent-pulmonary-hypertension-of-the-newborn
#16
REVIEW
Mei-Yin Lai, Shih-Ming Chu, Satyan Lakshminrusimha, Hung-Chih Lin
Persistent pulmonary hypertension (PPHN) is a consequence of failed pulmonary vascular transition at birth and leads to pulmonary hypertension with shunting of deoxygenated blood across the ductus arteriosus (DA) and foramen ovale (FO) resulting in severe hypoxemia, and it may eventually lead to life-threatening circulatory failure. PPHN is a serious event affecting both term and preterm infants in the neonatal intensive care unit. It is often associated with diseases such as congenital diaphragmatic hernia, meconium aspiration, sepsis, congenital pneumonia, birth asphyxia and respiratory distress syndrome...
August 10, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28920512/rhythmic-three-part-harmony-the-complex-interaction-of-maternal-placental-and-fetal-circadian-systems
#17
Peter J Mark, Rachael C Crew, Michaela D Wharfe, Brendan J Waddell
From the perspective of circadian biology, mammalian pregnancy presents an unusual biological scenario in which an entire circadian system (i.e., that of the fetus) is embodied within another (i.e., that of the mother). Moreover, both systems are likely to be influenced at their interface by a third player, the placenta. Successful pregnancy requires major adaptations in maternal physiology, many of which involve circadian changes that support the high metabolic demands of the growing fetus. A functional role for maternal circadian adaptations is implied by the effects of circadian disruption, which result in pregnancy complications including higher risks for miscarriage, preterm labor, and low birth weight...
September 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28920494/early-postnatal-weight-gain-as-a-predictor-for-the-development-of-retinopathy-of-prematurity
#18
Manoj Biniwale, Angela Weiner, Smeeta Sardesai, Rowena Cayabyab, Lorayne Barton, Rangasamy Ramanathan
OBJECTIVE: To validate the reliability of early postnatal weight gain as an accurate predictor of type 1 retinopathy of prematurity (ROP) requiring treatment in a large predominantly Hispanic US cohort with the use of an online tool called WINROP (weight, neonatal retinopathy of prematurity (IGF-1), neonatal retinopathy of prematurity). STUDY DESIGN: Retrospective cohort study consisted of preterm infants < 32 weeks gestation and birth weight < 1500 grams...
September 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28920101/potential-therapeutic-targets-in-nrf2-dependent-protection-against-neonatal-respiratory-distress-disease-predicted-by-cdna-microarray-analysis-and-bioinformatics-tools
#19
Hye-Youn Cho, Xuting Wang, Jianying Li, Douglas A Bell, Steven R Kleeberger
Hyperoxia exposure of newborn rodents has served as a model for bronchopulmonary dysplasia (BPD) phenotypes found in a sub-population of human premature infants. We previously demonstrated that Nrf2 modulates molecular events during saccular-to-alveolar lung maturation and also has a protective role in the pathogenesis of hyperoxia-induced acute lung injury, mortality, arrest of saccular-to-alveolar transition, and lung injury, using Nrf2-deficient and wild-type neonate mice. In this review, we describe how whole-genome transcriptome analyses can identify the means through which Nrf2 transcriptionally modulates organ injury and morphology, cellular growth/proliferation, vasculature development, and immune response during BPD-like pathogenesis...
December 2016: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/28920026/giant-cervico-thoracic-cystic-hygroma-in-a-preterm-a-case-report
#20
Rahul Mansing Kadam, A Narendra Kumar, Vsv Prasad, Sudha Boda
Cystic hygroma is a benign, painless loculated lymphatic proliferation, which occur due to a combination of sequestration from developing lymphatic system, abnormal budding of the lymphatic system or lack of development of the normal connections between venous and lymphatic drainage. We report a case of giant cervico-thoracic cystic hygroma in a preterm neonate with management options and a brief review of literature.
July 2017: Journal of Neonatal Surgery
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