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Autograft

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https://www.readbyqxmd.com/read/28530157/muscle-secreted-factors-improve-anterior-cruciate-ligament-graft-healing-an-in-vitro-and-in-vivo-analysis
#1
Corina Adriana Ghebes, Nathalie Groen, Yau Chuk Cheuk, Sai Chuen Fu, Hugo Fernandes, Daniel B Saris
One of the ligaments most often damaged during sports - the anterior cruciate ligament (ACL) - has poor healing capacity. Upon damage, reconstructive surgery is performed to restore the mechanical stability of the knee and to reduce the inflammatory milieu otherwise present in the joint. A return to normal activities, however, takes between 9 and 12 months. Thus, strategies capable of improving ACL graft healing are needed. Embryonic development of tendon and ligament (T/L) is regulated by a crosstalk between different cell types...
May 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28530131/a-novel-combination-of-a-polycaprolactone-fumarate-pclf-scaffold-with-polyethylene-terephthalate-pet-sutures-for-intra-articular-ligament-regeneration
#2
Joshua Parry, Eric R Wagner, Peter Kok, Mahrokh Dadsetan, Michael J Yaszemski, Andre J van Wijnen, Sanjeev Kakar
Intra-articular ligamentous injuries are typically unrepairable and have limited outcomes after graft reconstruction. A combination of porous polycaprolactone fumarate (PCLF) scaffolds with polyethylene terephthalate (PET) sutures was developed with the goal of regenerating intra-articular ligaments. Scaffolds were fabricated by injecting PCLF over 3D-printed molds containing two strands of PET suture down its central pore followed by crosslinking. Scaffolds were seeded with human mesenchymal stem cells (MSCs) from adipose tissue...
May 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28529763/characterisation-of-a-novel-poly-ether-ether-ketone-calcium-sulphate-composite-for-bone-augmentation
#3
Erik A B Hughes, Liam M Grover
BACKGROUND: Calcium sulphate (CS) has been used in bone grafting since the 1800s. It has not replaced autograft as the gold standard, however, since its dissolution occurs rapidly in bodily fluids, meaning that the material cannot support long-term bone growth. Here, the polymer poly (ether ether ketone) (PEEK) was used to slow dissolution in in vitro physiological environments and augment the mechanical properties of the material. METHODS: PEEK/CS specimens were fabricated by combining powders of PEEK and CS with water, resulting in a hardening paste...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28529011/the-effect-of-in-vivo-created-vascularized-neurotube-on-peripheric-nerve-regeneration
#4
Abdul Kerim Yapici, Yalcin Bayram, Hakan Akgun, Recep Gumus, Fatih Zor
INTRODUCTION: Creating vascularized nerve conduits for treatment of nerve gaps have been researched, however, these methods need microsurgical anastomosis thereby complicating the nerve repair process. Thus, the concept of vascularized nerve conduits has not popularized up till now. The aim of this study is to evaluate the effects of vascularized and non-vascularized biological conduits on peripheral nerve regeneration. MATERIAL AND METHODS: Following ethical board approval, 15 Sprague-Dawley rats were used in the study...
May 11, 2017: Injury
https://www.readbyqxmd.com/read/28523641/sandwich-bone-graft-for-vertical-augmentation-of-the-posterior-maxillary-region-a-case-report-with-9-year-follow-up
#5
Kenko Tanaka, Irena Sailer, Yoshihiro Kataoka, Shinnosuke Nogami, Tetsu Takahashi
The loss of teeth followed by bone resorption often lead to defects in the alveolar ridge, making installation of dental implants difficult. Correction of such bone defects, especially lack of height of the ridge, is a difficult problem for all dental surgeons. This report describes the outcome of treatment after alveolar ridge augmentation in the atrophic posterior maxillary region via segmental sandwich osteotomy combined with placement of an interpositional autograft prior to placement of endosseous implants...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28523324/anatomical-features-and-prosthetic-considerations-of-edentulous-patients-with-mandibular-reconstruction-with-autograft-performed-more-than-40-years-ago
#6
Cătălina Murariu-Măgureanu, Cristina Teodora Preoteasa, Laura Iosif, Marina Imre, Marian Cuculescu, Elena Preoteasa
In this manuscript there are presented two cases, both with mandibular reconstruction with autograft harvested from the iliac crest, performed more than 40 years ago, but with different bone defect etiology, i.e., mandibular dysplasia and mandibular fracture, both having currently extensive tooth loss in the mandible, being in need for prosthetic rehabilitation. These cases confirm that reconstructive surgery of mandibular bone defects with autograft from iliac crest has a satisfactory long-term outcome, providing acceptable conditions for prosthetic rehabilitation...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28516106/a-cost-effectiveness-analysis-of-surgical-treatment-modalities-for-chondral-lesions-of-the-knee-microfracture-osteochondral-autograft-transplantation-and-autologous-chondrocyte-implantation
#7
REVIEW
John B Schrock, Matthew J Kraeutler, Darby A Houck, Matthew B McQueen, Eric C McCarty
BACKGROUND: Numerous surgical options exist to treat chondral lesions in the knee, including microfracture (MFx), osteochondral autograft transplantation (OAT), first-generation autologous chondrocyte implantation (ACI-1), and next-generation ACI (ACI-2). PURPOSE: To compare the cost-effectiveness of MFx, OAT, and ACI-1. The secondary purpose of this study was to compare the functional outcomes of MFx, OAT, ACI-1, and ACI-2. STUDY DESIGN: Systematic review; Level of evidence, 2...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28515335/in-situ-bone-tissue-engineering-via-ultrasound-mediated-gene-delivery-to-endogenous-progenitor-cells-in-mini-pigs
#8
Maxim Bez, Dmitriy Sheyn, Wafa Tawackoli, Pablo Avalos, Galina Shapiro, Joseph C Giaconi, Xiaoyu Da, Shiran Ben David, Jayne Gavrity, Hani A Awad, Hyun W Bae, Eric J Ley, Thomas J Kremen, Zulma Gazit, Katherine W Ferrara, Gadi Pelled, Dan Gazit
More than 2 million bone-grafting procedures are performed each year using autografts or allografts. However, both options carry disadvantages, and there remains a clear medical need for the development of new therapies for massive bone loss and fracture nonunions. We hypothesized that localized ultrasound-mediated, microbubble-enhanced therapeutic gene delivery to endogenous stem cells would induce efficient bone regeneration and fracture repair. To test this hypothesis, we surgically created a critical-sized bone fracture in the tibiae of Yucatán mini-pigs, a clinically relevant large animal model...
May 17, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28514773/a-feasibility-study-of-the-full-outpatient-conduction-of-hematopoietic-transplants-in-persons-with-multiple-sclerosis-employing-autologous-non-cryopreserved-peripheral-blood-stem-cells
#9
Guillermo J Ruiz-Argüelles, Andrés A León-Peña, Mónica León-González, Ana Karen Nuñez-Cortes, Juan Carlos Olivares-Gazca, Iván Murrieta-Alvarez, Jocelyn Vargas-Espinosa, Emilio Medina-Ceballos, Yahveth Cantero-Fortiz, Alejandro Ruiz-Argüelles, Manuel A Ruiz-Delgado, Rodrigo J Ruiz-Delgado, Guillermo Ruiz-Reyes, Manuel Priesca-Marín, Merari Starlight Torres-Priego, David Blumenkron-Marroquin, Guillermo J Ruiz-Delgado
BACKGROUND: With the goal of achieving immune system reset, autologous hematopoietic stem cell transplantations have been performed in patients with multiple sclerosis (MS). MATERIAL AND METHODS: Two hundred and eighty-six consecutive patients with MS were autografted in a single center using non-frozen peripheral blood stem cells (PBSCs), on an outpatient basis and conditioning with cyclophosphamide and rituximab. The protocol was registered in ClinicalTrials.gov identifier NCT02674217...
May 18, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28512421/when-an-easy-thing-goes-wrong-foreign-body-induced-granuloma-associated-scleritis-following-pterygium-surgery
#10
Pedro Coelho, Carlos Menezes, Pedro Rodrigues, Rita Gonçalves, Tiago Maio, Jorge Moreira, Paula Tenedório
PURPOSE: To report a case of pterygium surgery with conjunctival autograft followed by focal necrotizing scleritis due to foreign body entrapment in the scleral bed. CASE REPORT/RESULTS: This is a case report of a 76-years-old male patient who underwent nasal pterygium surgery and developed focal necrotizing scleritis secondary to foreign body entrapment under conjunctival autograft. One month following surgery, slit-lamp examination demonstrated a progressive thinning of the surgical area with focal inflammatory signs...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28508295/mri-based-tendon-bone-healing-is-related-to-the-clinical-functional-scores-at-the-first-year-after-anterior-cruciate-ligament-reconstruction-with-hamstring-tendon-autograft
#11
Hong-Yun Li, Hong Li, Zi-Ying Wu, Ji-Wu Chen, Shi-Yi Chen
PURPOSE: The correlation between tendon bone healing and clinical functional scores after anterior cruciate ligament reconstruction (ACLR) using four-stranded hamstring tendon autograft has rarely being reported. The purpose of this study was to determine the correlation between magnetic resonance imaging (MRI)-based tendon bone healing and clinical functional scores after ACLR using hamstring tendon. METHODS: Thirty-eight patients with ACLR using four-stranded hamstring tendon autograft were included in this prospective study in the authors' hospital from 2013 to 2014...
May 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28507978/modified-tension-slide-technique-for-anatomical-distal-biceps-tenodesis-using-a-bicortical-endobutton-and-a-tenodesis-screw
#12
Jagadish Prabhu, Mohammed Khalid Faqi, Fahad Al-Khalifa, Rashad Khamis Awad
INTRODUCTION: Many surgical techniques have been described in the literature. In this article, we describe surgical technical details along with tips and tricks of distal biceps tendon tenodesis using the EndoButton and tension - slide technique, a modification of the suspensory cortical button technique, which allows the surgeon to tension and repairs the biceps tendon through the single longitudinal anterior incision. This modification in surgical technique of using dual implants, i...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28507956/an-unusual-case-of-giant-cell-tumor-of-first-metatarsal-a-rare-case-report-and-review-of-literature
#13
Kumar Prashant, Tulsi Das Bhattacharyya, Herman Frank, Prema Ram
INTRODUCTION: Giant cell tumor (GCT) or osteoclastoma is an osteolytic, mostly benign but locally aggressive tumor occurring in young adults at the epiphysis. Area of predilection is mainly long bones (85-90%). 4% of GCT are also found in iliac bone, spine and only 2% in hand (of which GCT phalanges are more common than metacarpal). GCT of metatarsal is a very rare occurrence with very few cases being reported so far. We report a case of GCT 1(st) metatarsal in a 40-year-old male which is a very rare entity...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28507781/isolated-posterior-cruciate-ligament-tears-an-update-of-management
#14
REVIEW
Alfonso Vaquero-Picado, E Carlos Rodríguez-Merchán
Isolated posterior cruciate ligament (PCL) tears are much less frequent than anterior cruciate ligament (ACL) tears.Abrupt posterior tibial translation (such as dashboard impact), falls in hyperflexion and direct hyperextension trauma are the most frequent mechanisms of production.The anterolateral bundle represents two-thirds of PCL mass and is reconstructed in single-bundle techniques.The PCL has an intrinsic capability for healing. This is the reason why, nowadays, the majority of isolated PCL tears are managed non-operatively, with rehabilitation and bracing...
April 2017: EFORT Open Rev
https://www.readbyqxmd.com/read/28501353/beta-tricalcium-phosphate-for-orthopedic-reconstructions-as-an-alternative-to-autogenous-bone-graft
#15
P Hernigou, A Dubory, J Pariat, D Potage, F Roubineau, S Jammal, C H Flouzat Lachaniette
Autogenous bone graft (autograft) remains the gold standard in the treatment of many orthopedic problems. However, graft harvest can lead to perioperative morbidity and increased cost. We tested the hypothesis that an osteoconductive matrix, beta-tricalcium phosphate (β-TCP), would be a safe and effective alternative to autograft alone. Beta-tricalcium phosphate (β-TCP) is considered as one of the most promising biomaterials for bone reconstruction. This study analyzes the outcomes of patients who received β-TCP as bone substitutes in orthopedic surgery...
May 10, 2017: Morphologie: Bulletin de L'Association des Anatomistes
https://www.readbyqxmd.com/read/28501341/chronic-boutonniere-deformity-cross-lateral-band-technique-using-palmaris-longus-autograft
#16
Serdar Duzgun, Alpay Duran, Ekrem Keskin, Ahmet K Yigit, Hasan Buyukdogan
PURPOSE: The purpose of this study was to evaluate the outcomes of treatment of chronic boutonniere deformity with a reconstruction technique using palmaris longus autograft. MATERIALS AND METHODS: Seven patients with chronic, posttraumatic, flexible boutonniere deformities referred to our clinic between January 2010 and September 2014 were included in the study. In all 7 patients, the lateral bands were deficient or damaged beyond repair. A novel reconstruction technique for chronic boutonniere deformity utilizing palmaris longus autograft was used...
May 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28489723/femtosecond-laser-assisted-pterygium-surgery
#17
Matthias Fuest, Yu-Chi Liu, Minas T Coroneo, Jodhbir S Mehta
PURPOSE: Pterygium is a prevalent ocular surface disorder. Conjunctival autografting (CAG) after pterygium resection is the gold standard treatment. Thinner CAGs without Tenon tissue provide better results but are technically difficult to achieve. We report on the first femtosecond laser (FSL)-assisted pterygium surgery (FLAPS) in humans. METHODS: In a clinical trial, we treated 6 eyes of 5 patients with FLAPS. After manual removal of the pterygium, CAGs were dissected with the Ziemer Z8 at 60-μm depth and glued into the resection defect...
May 9, 2017: Cornea
https://www.readbyqxmd.com/read/28489628/lengthening-of-newly-formed-humerus-after-autologous-fibula-graft-transplantation-following-intercalary-tumor-resection
#18
Hakan Pilge, Martin Ruppert, Bernd Bittersohl, Bettina Westhoff, Rüdiger Krauspe
Secondary limb lengthening after intercalary bone resection in pediatric patients is still challenging. After the resection, a free fibula autograft can be used to reconstruct the osseous gap. However, in particular in young pediatric patients, insufficient growth of the epiphyseal plate after transplantation may lead to a significant limb-length discrepancy (LLD). In this case, the autograft was used for limb lengthening. We report on the lengthening of a humerus regenerate after fibula autograft transplantation into a humeral defect in a pediatric/young adolescent patient...
May 5, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28489563/efficacy-of-fibrin-glue-versus-sutures-for-attaching-conjunctival-autografts-in-pterygium-surgery-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis-of-evidence
#19
Aihua Lan, Feifan Xiao, Yun Wang, Zhen Luo, Qixin Cao
Previous meta-analyses have been conducted to compare the efficacy of fibrin glue (FG) versus sutures in pterygium surgery; however, additional clinical trials have since been published. Therefore, we conducted an updated meta-analysis to further explore the association between FG application in pterygium surgery, and the recurrence rate, complication rate, and surgical duration. An electronic literature search for eligible studies published before July 29, 2016 was conducted across multiple databases. Odds ratios (ORs), standardized mean difference (SMD), and 95% confidence intervals (CI) were calculated...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28489283/inflammatory-responses-matrix-remodeling-and-re-epithelialization-after-fractional-co2-laser-treatment-of-scars
#20
Danielle M DeBruler, Britani N Blackstone, Molly E Baumann, Kevin L McFarland, Brian C Wulff, Traci A Wilgus, J Kevin Bailey, Dorothy M Supp, Heather M Powell
BACKGROUND AND OBJECTIVE: Fractional CO2 laser therapy has been used to improve scar pliability and appearance; however, a variety of treatment protocols have been utilized with varied outcomes. Understanding the relationship between laser power and extent of initial tissue ablation and time frame for remodeling could help determine an optimum power and frequency for laser treatment. The characteristics of initial injury caused by fractional CO2 laser treatment, the rates of dermal remodeling and re-epithelialization, and the extent of inflammation as a function of laser stacking were assessed in this study in a porcine scar model...
May 10, 2017: Lasers in Surgery and Medicine
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