Subhabrata Mitra, Kelly Harvey-Jones, Igor Kraev, Vinita Verma, Christopher Meehan, Alison Mintoft, Georgina Norris, Ellie Campbell, Katie Tucker, Nicola J Robertson, Mariya Hristova, Sigrun Lange
Neonatal seizures are commonly associated with acute perinatal brain injury, while understanding regarding the downstream molecular pathways related to seizures remains unclear. Furthermore, effective treatment and reliable biomarkers are still lacking. Post-translational modifications can contribute to changes in protein function, and post-translational citrullination, which is caused by modification of arginine to citrulline via the calcium-mediated activation of the peptidylarginine deiminase (PAD) enzyme family, is being increasingly linked to neurological injury...
July 16, 2023: International Journal of Molecular Sciences