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Phenobarbitone

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https://www.readbyqxmd.com/read/28088734/in-vivo-and-in-silico-sedative-hypnotic-like-activity-of-7-methyljuglone-isolated-from-diospyros-lotus-l
#1
Abdur Rauf, Sengul Uysal, Taibi Ben Hadda, Ghias Uddin, Muhammad Asif Nawaz, Haroon Khan, Bina S Siddiqui, Muslim Raza, Saud Bawazeer, Gokhan Zengin
Diospyros lotus L. possesses different therapeutic activities such as antioxidant, anti-proliferative, anti-microbial and sedative. However, no studies on the sedative-hypnotic activity of 7-methyljuglone are reported. In the present study, we have evaluated in vivo the anxiolytic-hypnotic like effects of 7-methyljuglone in mice with open field and phenobarbitone-induced sleeping time tests. We have also assessed in silico the involvement of GABAA, GABAB and 5HT1 neurotransmission in its mechanism of action...
January 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28076313/ethnopharmacological-investigation-of-the-aerial-part-of-phragmites-karka-poaceae
#2
Ramiz Ahmed Sultan, Mohammad Shah Hafez Kabir, Mir Muhammad Nasir Uddin, Mohi Uddin, Zobaer Al Mahmud, Sheikh Zahir Raihan, Nazmul Qais
BACKGROUND: In this ethnopharmacological study, methanolic extract of the aerial plant parts of Phragmites karka (Family: Poaceae) and its petroleum ether and carbon tetrachloride fractions were investigated for bioactivities in Swiss-albino mice, namely, analgesic, central nervous system (CNS) depressant, hypoglycemic, and antidiarrheal activity. METHODS: The cold methanolic extract of the aerial plant parts of Phragmites karka (MEPK) was first prepared, and it was then further fractionated as petroleum ether (PEFMEPK) and carbon tetrachloride (CTFMEPK) fractions...
January 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28070612/macrolide-antibiotics-differentially-influence-human-hepg2-cytotoxicity-and-modulate-intrinsic-extrinsic-apoptotic-pathways-in-rat-hepatocellular-carcinoma-model
#3
Nagwa I Abdel-Hamid, Mona F El-Azab, Yasser M Moustafa
This study was designed to examine the potential antitumor effect of some macrolides: clarithromycin, azithromycin, and erythromycin on chemically induced hepatocellular carcinoma (HCC) in rats and on human hepatoma cells (HepG2) as well. The possible underlying antiapoptotic mechanisms were investigated. Antiproliferative activity was assessed in HepG2 using Sulforhodamine-B staining method. In vivo, HCC was induced in rats by initiation-selection-promotion protocol using diethylnitrosamine (200 mg/kg, single i...
January 9, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27976799/carbamazepine-versus-phenobarbitone-monotherapy-for-epilepsy-an-individual-participant-data-review
#4
REVIEW
Sarah J Nolan, Anthony G Marson, Jennifer Weston, Catrin Tudur Smith
BACKGROUND: This is an updated version of the original Cochrane Review, first published in Issue 1, 2003 and updated in 2015. This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment, up to 70% of individuals with active epilepsy have the potential to become seizure-free and go into long-term remission shortly after starting drug therapy with a single antiepileptic drug in monotherapy...
15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27917768/iatrogenic-medication-errors-in-a-paediatric-intensive-care-unit-in-durban-south-africa
#5
A Gokhul, P M Jeena, A Gray
BACKGROUND: Iatrogenic medication errors due to calculation errors are an under-reported concern in children. OBJECTIVE: To determine the incidence and source of iatrogenic medication errors in a paediatric intensive care unit (PICU). METHODS: A prospective study was conducted in the PICU at Inkosi Albert Luthuli Hospital, Durban, South Africa, over a 3-month period in 2014. Medication-related calculation skills of medical practitioners and nurses were assessed through the voluntary anonymous completion of a questionnaire...
December 1, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27889710/effect-of-withholding-phenobarbitone-maintenance-in-neonatal-seizures-a-randomized-controlled-trial
#6
Pranjali Saxena, Abhishek Singh, Amit Upadhyay, Priyanka Gupta, Sangeeta Sharma, Sreenivas Vishnubatla
OBJECTIVE: To compare the effect of withholding maintenance phenobarbitone on breakthrough seizures. DESIGN: A double blind randomized controlled trial. SETTING: Level II neonatal intensive care unit (NICU) of a teaching hospital in Northern India. PARTICIPANTS: 152 term and near term neonates (34 weeks of gestation age) with admission weight ≥2 kg with clinically apparent seizures who received intravenous (IV) loading dose of 20 mg/kg of phenobarbitone...
December 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27851887/suspected-phenobarbitone-hypersensitivity-with-acute-liver-failure-in-a-dog
#7
L Bosseler, I Cornelis, P Defauw, S Daminet, R Ducatelle
No abstract text is available yet for this article.
December 14, 2016: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/27771659/serum-phenobarbitone-levels-in-neonates-with-seizures-some-clarifications
#8
A Shashidhar
No abstract text is available yet for this article.
September 8, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27749249/ionophore-based-potentiometric-pvc-membrane-sensors-for-determination-of-phenobarbitone-in-pharmaceutical-formulations
#9
Haitham Alrabiah, Abdulrahman Al-Majed, Mohammed Abounassif, Gamal A E Mostafa
The fabrication and development of two polyvinyl chloride (PVC) membrane sensors for assaying phenobarbitone sodium are described. Sensors 1 and 2 were fabricated utilizing β- or γ-cyclodextrin as ionophore in the presence of tridodecylmethylammonium chloride as a membrane additive, and PVC and dioctyl phthalate as plasticizer. The analytical parameters of both sensors were evaluated according to the IUPAC guidelines. The proposed sensors showed rapid, stable anionic response (-59.1 and -62.0 mV per decade) over a relatively wide phenobarbitone concentration range (5...
December 1, 2016: Acta Pharmaceutica
https://www.readbyqxmd.com/read/27704404/tablet-splitting-of-antiepileptic-drugs-in-pediatric-epilepsy-potential-effect-on-plasma-drug-concentrations
#10
Ravi Prasad Nidanapu, Sundaram Rajan, Subramanian Mahadevan, Batmanabane Gitanjali
INTRODUCTION: Tablet splitting is the process of dividing a tablet into portions to obtain a prescribed dose of medication. Very few studies have investigated whether split parts of a tablet deliver the expected amount of drug to patients. OBJECTIVE: Our objectives were to evaluate the split parts of adult-dose tablet formulations for percentage of weight deviation, weight uniformity, weight loss, drug content, and the content uniformity of four antiepileptic drugs (AEDs) prescribed to pediatric patients...
December 2016: Paediatric Drugs
https://www.readbyqxmd.com/read/27639708/effect-of-methanol-extract-of-trigonella-foenum-graecum-l-seeds-on-anxiety-sedation-and-motor-coordination
#11
Tahira Assad, Rafeeq Alam Khan
Currently available anxiolytics cause numerous adverse effects and show craving and tolerance during long term treatment. Currently traditional medicines have been re-evaluated widely through work on various plant species. Numerous plants in traditional system show pharmacological activity with unlimited prospective for therapeutic use. Hence we planned to evaluate the effect of methanol extract of T. foenum-graecum L. seeds on anxiety, sedation and motor coordination in mice at different doses following 15 days of oral feeding...
September 17, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27601113/neonatal-tetanus-associated-with-skin-infection
#12
M Maharaj, N Dungwa
A 1-week-old infant was brought to a regional hospital with a history of recurrent seizures following lower abdominal septic skin infection. She was found to have neonatal tetanus, and a spatula test was positive. The tetanus infection was associated with a superficial skin infection, common in neonates. Treatment included sedatives (diazepam, chlorpromazine, phenobarbitone and morphine), muscle relaxants, antibiotics and ventilation in the neonatal intensive care unit. Intrathecal and intramuscular immunoglobulin were given, and the wound was treated...
September 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27570385/polycystic-ovary-syndrome-in-patients-on-antiepileptic-drugs
#13
Lakshminarayanapuram G Viswanathan, Parthasarathy Satishchandra, Bipin C Bhimani, Janardhan Yc Reddy, Batchu S Rama Murthy, Doddaballapura K Subbakrishna, Sanjib Sinha
OBJECTIVE: This study aims to discuss the prevalence of polycystic ovary (PCO) and Polycystic ovary syndrome (PCOS) in women with epilepsy (WWE) on valproate (VPA), carbamazepine (CBZ), or phenobarbitone (PB), drug naive WWE and women with bipolar affective disorder (BPAD) on VPA. MATERIALS AND METHODS: This prospective study included 190 women aged 18-45 years, who had epilepsy or BPAD (on VPA), and consented for study. Patients were grouped as Group 1 (n = 40): WWE on VPA, Group 2 (n = 50): WWE on CBZ, Group 3 (n = 50): WWE on PB, Group 4 (n = 30): drug naïve WWE, and Group 5 (n = 20): women with BPAD on VPA...
July 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27478435/pharmacological-evaluation-of-naproxen-metal-complexes-on-antinociceptive-anxiolytic-cns-depressant-and-hypoglycemic-properties
#14
Md Sharif Hasan, Narhari Das, Zobaer Al Mahmud, S M Abdur Rahman
Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model. The CNS depressant activity of naproxen metal complexes was assessed using phenobarbitone-induced sleeping time test and the hypoglycemic test was performed using oral glucose tolerance test...
2016: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/27302918/comparing-the-effects-of-first-line-antiepileptic-drugs-on-the-gait-of-dogs-with-idiopathic-epilepsy
#15
E J Suiter, R M A Packer, H A Volk
Idiopathic epilepsy (IE) is a common chronic neurological disease of the dog. Previous studies of anti-epileptic drug (AED) treatment have indicated that acceptable AED adverse effects are as important to owners as reductions in seizure frequency. AEDs in both dogs and human beings are frequently associated with the adverse-effect ataxia. The aim of this study was to compare ataxia levels in dogs with IE treated chronically with phenobarbitone or imepitoin, the two currently available first-line AED treatments...
June 25, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27254045/serum-phenobarbitone-levels-in-term-and-near-term-neonates-with-seizures
#16
Sanober Wasim, Amit Upadhyay, Monica Roy, Pranjali Saxena, Neelam Chillar
OBJECTIVE: To evaluate serum phenobarbitone levels in neonates with seizures and to evaluate the effect of repeated loading dose on serum phenobarbitone levels. METHODS: In this prospective observational study conducted in a tertiary care centre of Northern India during 2011- 2012, 99 neonates admitted with seizureswere included.Serum phenobarbitone levels in neonates with seizures at 20 minutes and 12 hours after the first loading dose of phenobarbitone were measured...
May 8, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27148886/neonatal-encephalopathy-in-new-zealand-demographics-and-clinical-outcome
#17
M Battin, L Sadler, V Masson, C Farquhar
AIM: To establish the incidence of moderate to severe neonatal encephalopathy (NE) in term infants from New Zealand and to document demographic characteristics and neonatal outcomes. METHODS: Cases were reported monthly via the New Zealand Paediatric Surveillance Unit (NZPSU). Data were collected from paediatricians for neonatal items and lead maternity carers for pregnancy and birth details. Term neonatal deaths in the Perinatal and Maternal Mortality Review Committee dataset that were because of hypoxia and/or neonatal deaths from hypoxic ischaemic encephalopathy were added to the cases identified via the NZPSU, if they had not previously been ascertained...
June 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27108085/status-of-neonatal-pain-assessment-and-management-in-jordan
#18
Nadin M Abdel Razeq, Akuma O Akuma, Sue Jordan
Current pain assessment and management in neonates need to be fully described before neonatal pain care can be optimized. This study's purpose was to report neonatal nurses' knowledge, existing pain assessment practice, and pharmacological pain management of neonates in Jordan. A cross-sectional descriptive study was conducted. Eighteen neonatal intensive care units in Jordan were included in the study. One hundred eighty-four neonatal nurses participated. Questionnaires were distributed by and returned to the neonatal intensive care units' managers between June and August 2014...
August 2016: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/27099654/management-of-pregnancy-in-crigler-najjar-syndrome-type-2
#19
Alisha Nitin Chaubal, Ruchir Patel, Dhaval Choksi, Kaivan Shah, Meghraj Ingle, Prabha Sawant
Crigler Najjar syndrome is associated with indirect hyperbilirubinemia due to a deficiency of enzyme Uridine Di Phospho Glucoronosyl Transferase (UDPGT). Presented here is a case of a female in the first trimester of pregnancy, who was diagnosed to have type 2 Crigler Najjar syndrome. We also discuss the management of this rare disease especially in pregnancy. Unconjugated bilirubin can cross the placental barrier causing neurological damage in the newborn. Patient was carefully monitored during pregnancy and treatment with phenobarbitone in low doses was adjusted such that the serum bilirubin levels were below 10 mg/dL...
April 18, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27027306/short-term-effects-of-phenobarbitone-on-electrographic-seizures-in-neonates
#20
Evonne Low, Nathan J Stevenson, Sean R Mathieson, Vicki Livingstone, Anthony C Ryan, Janet M Rennie, Geraldine B Boylan
BACKGROUND: Phenobarbitone is the most common first-line anti-seizure drug and is effective in approximately 50% of all neonatal seizures. OBJECTIVE: To describe the response of electrographic seizures to the administration of intravenous phenobarbitone in neonates using seizure burden analysis techniques. METHODS: Multi-channel conventional EEG, reviewed by experts, was used to determine the electrographic seizure burden in hourly epochs...
2016: Neonatology
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