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Glioblastoma AND surgical complication

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https://www.readbyqxmd.com/read/27690658/laser-interstitial-thermal-therapy-followed-by-minimal-access-transsulcal-resection-for-the-treatment-of-large-and-difficult-to-access-brain-tumors
#1
James Wright, Jessey Chugh, Christina Huang Wright, Fernando Alonso, Alia Hdeib, Haley Gittleman, Jill Barnholtz-Sloan, Andrew E Sloan
OBJECTIVE Laser interstitial thermal therapy (LITT), sometimes referred to as "stereotactic laser ablation," has demonstrated utility in a subset of high-risk surgical patients with difficult to access (DTA) intracranial neoplasms. However, the treatment of tumors larger than 10 cm(3) is associated with suboptimal outcomes and morbidity. This may limit the utility of LITT in dealing with precisely those large or deep tumors that are most difficult to treat with conventional approaches. Recently, several groups have reported on minimally invasive transsulcal approaches utilizing tubular retracting systems...
October 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27668386/glioblastoma-overview-of-disease-and-treatment
#2
Mary Elizabeth Davis
BACKGROUND: Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults. Current treatment options at diagnosis are multimodal and include surgical resection, radiation, and chemotherapy. Significant advances in the understanding of the molecular pathology of GBM and associated cell signaling pathways have opened opportunities for new therapies for recurrent and newly diagnosed disease. Innovative treatments, such as tumor-treating fields (TTFields) and immunotherapy, give hope for enhanced survival...
October 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27643918/intraoperative-probe-based-confocal-laser-endomicroscopy-in-surgery-and-stereotactic-biopsy-of-low-grade-and-high-grade-gliomas-a-feasibility-study-in-humans
#3
Vladislav Pavlov, David Meyronet, Vincent Meyer-Bisch, Xavier Armoiry, Brian Pikul, Chloé Dumot, Pierre-Aurelien Beuriat, Francesco Signorelli, Jacques Guyotat
BACKGROUND: The management of gliomas is based on precise histologic diagnosis. The tumor tissue can be obtained during open surgery or via stereotactic biopsy. Intraoperative tissue imaging could substantially improve biopsy precision and, ultimately, the extent of resection. OBJECTIVE: To show the feasibility of intraoperative in vivo probe-based confocal laser endomicroscopy (pCLE) in surgery and biopsy of gliomas. METHODS: In our prospective observational study, 9 adult patients were enrolled between September 2014 and January 2015...
October 2016: Neurosurgery
https://www.readbyqxmd.com/read/27400094/fully-endoscopic-resection-of-intra-axial-brain-lesions-using-neuronavigated-pediatric-anoscope
#4
Murat Kutlay, Cahit Kural, Ilker Solmaz, Ozkan Tehli, Caglar Temiz, Mehmet Daneyemez, Yusuf Izci
AIM: To present a new simple disposable tubular retractor which provides fully endoscopic resections of the intraaxial brain lesions. MATERIAL AND METHODS: A total of 13 patients underwent surgical resection of an intraaxial brain lesion larger than 3 cm with a fully endoscopic approach using the navigation-guided pediatric anoscope. The anoscope was adapted to serve as a tubular retractor. All lesions were resected under endoscopic visualization and navigation guidance...
2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27337238/parieto-occipital-interhemispheric-precuneal-approach-to-the-lesions-of-the-atrium-experience-with-66-patients
#5
Murat Geyýk, Ýbrahim Erkutlu, Mehmet Alptekýn, Ýnan Gezgýn, Ayþe Mizrak, Serhat Pusat, Abdulvahap Gök
AIM: Atrium (Trigone) is the most common site for the intraventricular lesions. Parieto-occipital interhemispheric precuneal approach (POIPA) is one of the particular way to reach these lesions. The aim of this study is to draw specific attention to the surgical difficulties of these lesions and to present our experience by this operative approach. MATERIAL AND METHODS: Sixty-six patients with the lesions located in the atrium of the lateral ventricles underwent surgical treatment in our institution using POIPA over a 13-year period...
December 28, 2015: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27091344/de-novo-glioblastoma-in-the-territory-of-a-recent-middle-cerebral-artery-infarction-and-a-residual-meningioma-pathogenesis-revisited
#6
Waseem Yaghmour, Maher E Kurdi, Saleh S Baeesa
BACKGROUND: The pathogenesis of glioblastoma is complex, and the implicated molecular mechanisms are yet to be understood. There are scattered reports describing a possible relationship between meningioma and glioblastoma and more rarely a relationship between infarction and glioblastoma. CASE PRESENTATION: We are reporting a 32-year-old male who developed left middle cerebral artery (MCA) infarction as a surgical complication for sphenoid meningioma. He developed recurrent symptoms 4 months later due to development of a glioblastoma adjacent to both the territory of the prior MCA infarct and the residual meningioma...
2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27013078/falsely-low-values-of-oxygen-saturation-measured-by-pulse-oximetry-in-a-boy-treated-with-chinese-herb-tea
#7
Agnes S Meidert, Alexander Lang, Georg Hennig, Patricia Bernasconi, Aurelia Peraud, Josef Briegel, Tanija K Hüttl
An 8-year-old boy suffering from progressive glioblastoma was scheduled for neurosurgery. Prior to induction of anaesthesia pulse oximetry measured 64 % saturation of oxygen (SpO2). Arterial blood gas analysis revealed normal oxygen saturation and normal oxygen partial pressure. After having ruled out technical problems of pulse oximetry the neurosurgical procedure was halted. Meticulous examination of the child's history and medication did not explain a possible interaction of drugs with pulse oximetry. A Chinese herb tea had been given to the child, but was then stopped on the day of admission...
March 25, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/26926064/versatile-utilization-of-real-time-intraoperative-contrast-enhanced-ultrasound-in-cranial-neurosurgery-technical-note-and-retrospective-case-series
#8
Ilya Lekht, Noah Brauner, Joshua Bakhsheshian, Ki-Eun Chang, Mittul Gulati, Mark S Shiroishi, Edward G Grant, Eisha Christian, Gabriel Zada
OBJECTIVE: Intraoperative contrast-enhanced ultrasound (iCEUS) offers dynamic imaging and provides functional data in real time. However, no standardized protocols or validated quantitative data exist to guide its routine use in neurosurgery. The authors aimed to provide further clinical data on the versatile application of iCEUS through a technical note and illustrative case series. METHODS: Five patients undergoing craniotomies for suspected tumors were included...
March 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/26791930/delaying-standard-combined-chemoradiotherapy-after-surgical-resection-does-not-impact-survival-in-newly-diagnosed-glioblastoma-patients
#9
Guillaume Louvel, Philippe Metellus, Georges Noel, Sophie Peeters, Jacques Guyotat, Julien Duntze, Pierre-Jean Le Reste, Phong Dam Hieu, Thierry Faillot, Fabien Litre, Nicolas Desse, Antoine Petit, Evelyne Emery, Jimmy Voirin, Johann Peltier, François Caire, Jean-Rodolphe Vignes, Jean-Luc Barat, Olivier Langlois, Philippe Menei, Sarah N Dumont, Marc Zanello, Edouard Dezamis, Frédéric Dhermain, Johan Pallud
BACKGROUND: To assess the influence of the time interval between surgical resection and standard combined chemoradiotherapy on survival in newly diagnosed and homogeneously treated (surgical resection plus standard combined chemoradiotherapy) glioblastoma patients; while controlling confounding factors (extent of resection, carmustine wafer implantation, functional status, neurological deficit, and postoperative complications). METHODS: From 2005 to 2011, 692 adult patients (434 men; mean of 57...
January 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/26775233/frailty-in-geriatric-glioblastoma-patients-a-predictor-of-operative-morbidity-and-outcome
#10
Michael Cloney, Randy D'Amico, Jordan Lebovic, Matthew Nazarian, Brad E Zacharia, Michael B Sisti, Jeffrey N Bruce, Guy M McKhann, Fabio M Iwamoto, Adam M Sonabend
BACKGROUND: Frailty is an emerging means of assessing overall health status and guiding management for geriatric patients. Frailty is associated with outcomes for many surgical indications in this age group. While half of all glioblastoma patients are 65 years old or older, frailty has not been examined in relation to surgery for glioblastoma. METHODS: We performed a retrospective study of patients age 65 years and older with pathologically confirmed glioblastoma at Columbia Presbyterian Hospital from 2000 to 2012; 319 patients were identified, 243 of whom underwent craniotomy for lobar lesions...
May 2016: World Neurosurgery
https://www.readbyqxmd.com/read/26621412/predicting-functional-impairment-in-brain-tumor-surgery-the-big-five-and-the-milan-complexity-scale
#11
Paolo Ferroli, Morgan Broggi, Silvia Schiavolin, Francesco Acerbi, Valentina Bettamio, Dario Caldiroli, Alberto Cusin, Emanuele La Corte, Matilde Leonardi, Alberto Raggi, Marco Schiariti, Sergio Visintini, Angelo Franzini, Giovanni Broggi
OBJECT The Milan Complexity Scale-a new practical grading scale designed to estimate the risk of neurological clinical worsening after performing surgery for tumor removal-is presented. METHODS A retrospective study was conducted on all elective consecutive surgical procedures for tumor resection between January 2012 and December 2014 at the Second Division of Neurosurgery at Fondazione IRCCS Istituto Neurologico Carlo Besta of Milan. A prospective database dedicated to reporting complications and all clinical and radiological data was retrospectively reviewed...
December 2015: Neurosurgical Focus
https://www.readbyqxmd.com/read/26351227/cerebellopontine-angle-tumors-in-infants-and-children
#12
Tadanori Tomita, Gordan Grahovac
OBJECTIVE: Cerebellopontine angle (CPA) and cerebellomedullary fissure (CMF) tumors are rare in children and information is scarce in the literature. This retrospective study reports their histological distribution and tumor origin, and describes surgical resections and post-operative outcome based upon the authors' consecutive personal series. METHODS: Clinical data of infants and children 16 years old or younger of age treated from 2001 to 2012 by a single surgeon was retrospectively reviewed...
October 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/26306931/glioblastoma-complicated-by-fatal-malignant-acute-ischemic-stroke-mri-finding-to-assist-in-tricky-surgical-decision
#13
Aymeric Amelot, Flore Baronnet-Chauvet, Edith Fioretti, Bertrand Mathon, Philippe Cornu, Aurélien Nouet, Dorian Chauvet
BACKGROUND: In most cases, glioblastomas are associated with seizures, headaches, neurological deficits, aphasia, or bleeding. But these tumors are rarely associated with cerebral infarction and never so deadly. CASE REPORT: A 40-year-old man presented with sudden morning isolated aphasia. One hour later, he developed a motor deficit at right upper member, quickly completed with a total right hemiplegia. Imaging studies revealed a left frontotemporal enhancing glioblastoma with a perilesional edema which produced an important mass effect on the posterior arm of the external capsule, on the primary motor cortex posteriorly and the entire sylvian valley anteriorly...
October 2015: Neuroradiology Journal
https://www.readbyqxmd.com/read/26243790/clinical-benefit-from-resection-of-recurrent-glioblastomas-results-of-a-multicenter-study-including-503-patients-with-recurrent-glioblastomas-undergoing-surgical-resection
#14
Florian Ringel, Haiko Pape, Michael Sabel, Dietmar Krex, Hans Christoph Bock, Martin Misch, Astrid Weyerbrock, Thomas Westermaier, Christian Senft, Philippe Schucht, Bernhard Meyer, Matthias Simon
BACKGROUND: While standards for the treatment of newly diagnosed glioblastomas exist, therapeutic regimens for tumor recurrence remain mostly individualized. The role of a surgical resection of recurrent glioblastomas remains largely unclear at present. This study aimed to assess the effect of repeated resection of recurrent glioblastomas on patient survival. METHODS: In a multicenter retrospective-design study, patients with primary glioblastomas undergoing repeat resections for recurrent tumors were evaluated for factors affecting survival...
January 2016: Neuro-oncology
https://www.readbyqxmd.com/read/26149222/impact-of-extent-of-resection-and-recurrent-surgery-on-clinical-outcome-and-overall-survival-in-a-consecutive-series-of-170-patients-for-glioblastoma-in-intraoperative-high-field-imri
#15
J Coburger, C R Wirtz, R W König
AIM: In patients with a glioblastoma (GBM), few unselected data exists using actual standard adjuvant treatment and contemporary surgical techniques like iMRI. Aim of study is to assess impact of EoR and recurrent surgery on survival and outcome. METHODS: We assessed a consecutive unselected series of 170 surgeries for GBM (2008-2014) applying intraoperative MRI(iMRI). All patients received adjuvant radio-chemo-therapy. Overallsurvival(OS), progression free survival (PFS), complications and new permanent neurological deficits(nPND) were assessed...
July 7, 2015: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/26142051/poor-prognosis-despite-aggressive-treatment-in-adults-with-intramedullary-spinal-cord-glioblastoma
#16
Ann Liu, Eric W Sankey, Chetan Bettegowda, Peter C Burger, George I Jallo, Mari L Groves
We report our institution's experience with adult patients who underwent surgery for intramedullary spinal cord glioblastoma. Spine involvement of glioblastoma is rare, representing 7.5% of all intramedullary gliomas and 1-3% of all spinal cord tumors. We performed a retrospective review of five male patients with intramedullary spinal cord glioblastoma who underwent surgical resection from 1990 to 2014. Demographic, operative, and postoperative factors were recorded. The median age at treatment was 31 years (range: 18-61) and all men presented with motor or sensory dysfunction...
October 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26136493/insulin-mediated-signaling-promotes-proliferation-and-survival-of-glioblastoma-through-akt-activation
#17
Yuanying Gong, Yufang Ma, Maksim Sinyuk, Sudan Loganathan, Reid C Thompson, Jann N Sarkaria, Wenbiao Chen, Justin D Lathia, Bret C Mobley, Stephen W Clark, Jialiang Wang
BACKGROUND: Metabolic complications such as obesity, hyperglycemia, and type 2 diabetes are associated with poor outcomes in patients with glioblastoma. To control peritumoral edema, use of chronic high-dose steroids in glioblastoma patients is common, which can result in de novo diabetic symptoms. These metabolic complications may affect tumors via profound mechanisms, including activation of insulin receptor (InsR) and the related insulin-like growth factor 1 receptor (IGF1R) in malignant cells...
January 2016: Neuro-oncology
https://www.readbyqxmd.com/read/26074434/the-safety-of-surgery-in-elderly-patients-with-primary-and-recurrent-glioblastoma
#18
Randy S D'Amico, Michael B Cloney, Adam M Sonabend, Brad Zacharia, Matthew N Nazarian, Fabio M Iwamoto, Michael B Sisti, Jeffrey N Bruce, Guy M McKhann
BACKGROUND: Glioblastoma (GBM) occurs more commonly in elderly patients. However, these patients are often excluded from clinical trials. The absence of solid evidence has resulted in a nihilistic view of GBM in the elderly and a traditionally conservative treatment approach. In particular, the safety of surgical resection for both primary and recurrent GBM is poorly understood in elderly patients. METHODS: In a retrospective cohort of patients aged ≥65 years, we examined selection for biopsy, surgical resection, and reoperation for recurrent disease...
October 2015: World Neurosurgery
https://www.readbyqxmd.com/read/25963474/-multiple-extraneural-metastasis-of-glioblastoma-multiforme
#19
J Undabeitia, M Castle, M Arrazola, C Pendleton, I Ruiz, E Úrculo
INTRODUCTION: Glioblastoma multiforme is the most frequent primary tumor in the brain. Despite improvements in its surgical, chemotherapy and radiotherapy treatment, prognosis remains poor. Extracranial metastases of glioblastoma are a rare complication in this disease. Its appearance has been described in lung, liver, bone or lymph nodes. CASE REPORT: We describe the case of a 20 year-old patient who complained of a subacute-onset headache. In the MRI an enhancing right temporal lesion was detected suggesting a high grade glioma as first diagnosis...
January 2015: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/25942630/risk-factors-for-glioblastoma-therapy-associated-complications
#20
Genevieve Ening, Fransiska Osterheld, David Capper, Kirsten Schmieder, Christopher Brenke
OBJECTIVE: Thromboembolic events, seizures, neurologic symptoms and adverse effects from corticosteroids and chemotherapies are frequent clinical complications seen in Glioblastoma (GB) patients. The exact impact these have on dismal patient outcome has not been fully elucidated. We aimed at assessing treatment associated complications, evaluating the impact on survival and defining risk factors. METHODS: Two hundred and thirty three consecutive adult patients operated on for newly diagnosed GB at a single tertiary institution over a 5-year-period (2006-2011) were assessed...
July 2015: Clinical Neurology and Neurosurgery
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