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Glioblastoma AND surgical complication

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https://www.readbyqxmd.com/read/29438526/magnetic-resonance-imaging-guided-laser-interstitial-thermal-therapy-for-glioblastoma-of-the-corpus-callosum
#1
Thomas L Beaumont, Alireza M Mohammadi, Albert H Kim, Gene H Barnett, Eric C Leuthardt
BACKGROUND: Glioblastoma of the corpus callosum is particularly difficult to treat, as the morbidity of surgical resection generally outweighs the potential survival benefit. Laser interstitial thermal therapy (LITT) is a safe and effective treatment option for difficult to access malignant gliomas of the thalamus and insula. OBJECTIVE: To assess the safety and efficacy of LITT for the treatment of glioblastoma of the corpus callosum. METHODS: We performed a multicenter retrospective analysis of prospectively collected data...
February 8, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29427817/national-trends-for-reoperation-in-elderly-patients-with-glioblastoma
#2
Yi-Ren Chen, Jon Sole, Beatrice Ugiliweneza, Eli Johnson, Eric Burton, Shiao Y Woo, Maria Koutourousiou, Brian Williams, Maxwell Boakye, Stephen Skirboll
BACKGROUND: Despite multimodal therapies extending patient survival, Glioblastoma (GBM) recurrence is all but a certainty. To date, there are few single-center studies looking at reoperations. Our study aimed to assess GBM reoperation trends nationally in elderly patients, with emphasis on outcomes. METHODS: The linked Surveillance, Epidemiology, and End Results (SEER) - Medicare database was searched to identify patients 66 years and older with GBM from 1997-2010...
February 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29392589/surgical-treatment-of-glioblastoma-in-the-elderly-the-impact-of-complications
#3
Michael Karsy, Nam Yoon, Lillian Boettcher, Randy Jensen, Lubdha Shah, Joel MacDonald, Sarah T Menacho
The diagnosis of glioblastoma (GBM) often carries a dismal prognosis, with a median survival of 14.6 months. A particular challenge is the diagnosis of GBM in the elderly population (age > 75 years), who have significant comorbidities, present with worse functional status, and are at higher risk with surgical treatments. We sought to evaluate the impact of current GBM treatment, specifically in the elderly population. The authors undertook a retrospective review of all patients aged 75 or older who underwent treatment for GBM from 1997 to 2016...
February 1, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29371158/brain-tumors
#4
REVIEW
J Ricardo McFaline-Figueroa, Eudocia Q Lee
Brain tumors are common, requiring general medical providers to have a basic understanding of their diagnosis and management. The most prevalent brain tumors are intracranial metastases from systemic cancers, meningiomas, and gliomas, specifically, glioblastoma. Central nervous system metastases may occur anywhere along the neuroaxis, and require complex multidisciplinary care with neurosurgery, radiation oncology, and medical oncology. Meningiomas are tumors of the meninges, mostly benign and often managed by surgical resection, with radiation therapy and chemotherapy reserved for high-risk or refractory disease...
January 22, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29361284/intraoperative-3-tesla-magnetic-resonance-imaging-our-experience-in-tumors
#5
A García-Baizán, A Tomás-Biosca, P Bartolomé Leal, P D Domínguez, R García de Eulate Ruiz, S Tejada, J L Zubieta
OBJECTIVE: To report our experience in the use of 3 tesla intraoperative magnetic resonance imaging (MRI) in neurosurgical procedures for tumors, and to evaluate the criteria for increasing the extension of resection. MATERIAL AND METHODS: This retrospective study included all consecutive intraoperative MRI studies done for neuro-oncologic disease in the first 13 months after the implementation of the technique. We registered possible immediate complications, the presence of tumor remnants, and whether the results of the intraoperative MRI study changed the surgical management...
January 17, 2018: Radiología
https://www.readbyqxmd.com/read/29339639/mri-guided-interstitial-laser-ablation-for-intracranial-lesions-a-large-single-institution-experience-of-133-cases
#6
Ashwin A Kamath, Daniel D Friedman, Carl D Hacker, Matthew D Smyth, David D Limbrick, Albert H Kim, Ammar H Hawasli, Eric C Leuthardt
BACKGROUND: Managing difficult-to-access lesions or surgically accessible lesions in fragile patients is a central problem in neurosurgery. MRI-guided interstitial laser ablation (ILA) is a minimally invasive option that may provide a safe means of treating these challenging patients. OBJECTIVE: We aim to (1) evaluate safety, efficacy, and preliminary outcomes within a diverse and large series of ILA treatments; and (2) report technical details and operative trends that proved useful over time in the authors' experience and that may be of use to neurosurgeons who perform ILA...
January 17, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29212066/fstl1-promotes-glioma-growth-through-the-bmp4-smad1-5-8-signaling-pathway
#7
Xin Jin, Er Nie, Xu Zhou, Ailiang Zeng, Tianfu Yu, Tongle Zhi, Kuan Jiang, Yingyi Wang, Junxia Zhang, Yongping You
BACKGROUND: Gliomas result in the highest morbidity and mortality rates of intracranial primary central nervous system tumors because of their aggressive growth characteristics and high postoperative recurrence. They are characterized by genetic instability, intratumoral histopathological variability and unpredictable clinical behavior in patients. Proliferation is a key aspect of the clinical progression of malignant gliomas, complicating complete surgical resection and enabling tumor regrowth and further proliferation of the surviving tumor cells...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29183864/surgery-for-recurrent-high-grade-glioma-after-treatment-with-bevacizumab
#8
Deborah T Blumenthal, Andrew A Kanner, Orna Aizenstein, Emanuela Cagnano, Ariel Greenberg, Dov Hershkovitz, Zvi Ram, Felix Bokstein
BACKGROUND: Bevacizumab (BVZ) is an FDA-approved anti-angiogenic agent used for treatment of recurrent glioblastoma. Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) following treatment with BVZ. OBJECTIVE: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG following treatment with BVZ. METHODS: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG following treatment with BVZ...
November 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29062690/paroxysmal-dysphasia-in-a-68%C3%A2-year-old-man-enhancing-the-mri-spectrum
#9
Ugur Sener, William O Tatum, Alfredo Quinones-Hinojosa, Deependra Mahato, Anteneh M Feyissa
Brain tumor-related epilepsy is a common complication of primary and metastatic brain tumors with seizures often representing the first manifestation of the tumor. The size and location of the tumor can make detection of epileptiform discharges on scalp electroencephalogram and safe surgical resection challenging. We describe a case of a patient with glioblastoma multiforme presenting as dominant temporal lobe epilepsy. Seizures were manifest as episodes of speech arrest on a background of long-standing history of episodic speech difficulty and headache...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28939537/usefulness-of-reintervention-in-recurrent-glioblastoma-an-indispensable-weapon-for-increasing-survival
#10
Juan Delgado-Fernandez, Maria Ángeles Garcia-Pallero, Guillermo Blasco, Juan R Penanes, Ricardo Gil-Simoes, Paloma Pulido, Rafael G Sola
BACKGROUND: Glioblastoma is the most frequent primary brain tumour and despite of complete treatment survival is still poor. The aim of this study is to define the utility of reoperation for improving survival in patients with recurrent glioblastoma, and determine other prognostic factors associated with longer survival. METHODS: we performed a retrospective analysis of those patients who underwent surgery and compared those who were operated two or more times and those who received surgery only once...
September 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28915414/evaluation-of-surgical-decision-making-and-resulting-outcome-in-patients-with-highly-eloquent-glioblastoma-results-of-a-multicenter-assessment
#11
Jan Coburger, Mirjam Renovanz, Oliver Ganslandt, Florian Ringel, Christian Rainer Wirtz, Javier Segovia von Riehm
INTRODUCTION: Treatment of glioblastoma(GB) patients amenable only for a subtotal resection(STR) is controversial. Since outcome of patients is affected by surgical management, our aim was to assess surgical decision making and resulting outcome in patients with highly eloquent GBs. PATIENTS AND METHODS: We retrospectively assessed GB patients with intended sub-total resection (STR) or stereotactic biopsy (STX) of 3 neurooncological centers operated between 2008 and 2013...
November 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28913317/reconstruction-of-a-complex-scalp-defect-after-the-failure-of-free-flaps-changing-plans-and-strategy
#12
Youn Hwan Kim, Gyeong Hoe Kim, Sang Wha Kim
The ideal scalp reconstruction involves closure of the defect with similar hair-bearing local tissue in a single step. Various reconstructions can be used including primary closure, secondary healing, skin grafts, local flaps, and microvascular tissue transfer. A 53-year-old female patient suffered glioblastoma, which had recurred for the second time. The neurosurgeons performed radial debridement and an additional resection of the tumor, followed by reconstruction using a serratus anterior muscle flap with a split-thickness skin graft...
June 2017: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/28806622/case-report-on-the-non-operative-management-of-a-retrievable-inferior-vena-cava-filter-perforating-the-duodenum
#13
Joseph S Fernandez-Moure, Keemberly Kim, M Haseeb Zubair, Wade R Rosenberg
INTRODUCTION: Deep vein thrombosis (DVT) continues to be a significant source of morbidity for surgical patients. Placement of a retrievable inferior vena cava (IVC) filter is used when patients have contraindications to anticoagulation or recurrent pulmonary embolism despite therapeutic anticoagulation. Although retrievable IVC filters are often used, they carry a unique set of risks. PRESENTATION OF CASE: A 67-year-old man presents to the Emergency Room (ER) following large volume melena and complaining of syncope...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28689368/maximize-surgical-resection-beyond-contrast-enhancing-boundaries-in-newly-diagnosed-glioblastoma-multiforme-is-it-useful-and-safe-a-single-institution-retrospective-experience
#14
Federico Pessina, Pierina Navarria, Luca Cozzi, Anna Maria Ascolese, Matteo Simonelli, Armando Santoro, Elena Clerici, Marco Rossi, Marta Scorsetti, Lorenzo Bello
The extent of surgical resection (EOR) has been recorded as conditioning outcome in glioblastoma multiforme (GBM) patients but no significant improvements were recorded in survival. The study aimed to evaluate the impact of EOR on survival, investigating the role of fluid-attenuated inversion recovery (FLAIR) abnormalities removal. 282 newly diagnosed GBM patients were treated with surgery followed by concurrent and adjuvant chemo-radiotherapy. The EOR was defined as: SUPr, in case of resection amounting to 100% of enhanced and FLAIR areas; gross total (GTR) in case of resection between 90 and 100% of enhanced areas with variable amount of FLAIR abnormalities; sub-total (STR), between 10 and 89%; biopsy (B) <10%...
October 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28669011/extent-of-resection-and-carmustine-wafer-implantation-safely-improve-survival-in-patients-with-a-newly-diagnosed-glioblastoma-a-single-center-experience-of-the-current-practice
#15
Alexandre Roux, Sophie Peeters, Marc Zanello, Rabih Bou Nassif, Georges Abi Lahoud, Edouard Dezamis, Eduardo Parraga, Emmanuelle Lechapt-Zalcmann, Frédéric Dhermain, Sarah Dumont, Guillaume Louvel, Fabrice Chretien, Xavier Sauvageon, Bertrand Devaux, Catherine Oppenheim, Johan Pallud
For newly diagnosed glioblastomas treated with resection in association with the standard combined chemoradiotherapy, the impact of Carmustine wafer implantation remains debated regarding postoperative infections, quality of life, and feasibility of adjuvant oncological treatments. To assess together safety, tolerance and efficacy of Carmustine wafer implantation and of extent of resection for glioblastoma patients in real-life experience. Observational retrospective monocentric study including 340 consecutive adult patients with a newly diagnosed supratentorial glioblastoma who underwent surgical resection with (n = 123) or without (n = 217) Carmustine wafer implantation as first-line oncological treatment...
October 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28645590/endoscopic-supracerebellar-transtentorial-approach-to-atrium-of-lateral-ventricle-preliminary-surgical-and-optical-considerations
#16
Tao Xie, Linjun Zhou, Xiaobiao Zhang, Wei Sun, Hailin Ding, Tengfei Liu, Ye Gu, Chongjing Sun, Fan Hu, Wei Zhu
OBJECTIVE: We sought to report the operative techniques of the endoscopic supracerebellar transtentorial approach (ESTA) to the atrium of the lateral ventricle, especially focusing on the role of the endoscope and analyzing optically related issues. METHODS: A retrospective data review was performed on 5 patients with lesions in the atrium of the lateral ventricle undergoing the ESTA. The patients were positioned in the three quarters prone position, and a paramidline linear incision was used...
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28440461/the-role-of-mir-451-in-the-switching-between-proliferation-and-migration-in-malignant-glioma-cells-ampk-signaling-mtor-modulation-and-rac1-activation-required
#17
Kai Zhao, Leilei Wang, Tao Li, Meng Zhu, Chen Zhang, Lei Chen, Pengfei Zhao, Hua Zhou, Shengping Yu, Xuejun Yang
Glioblastoma multiforme (GBM), WHO grade IV astrocytoma, is the most common primary neoplasm of the central nervous system (CNS) and has the highest malignancy and mortality rates. The invasive nature of GBM complicates surgical resection and restricts chemotherapeutic access, contributing to poor patient prognosis. The migration of tumor cells is closely related to the tumor cell proliferation. The acquisition of migratory capability, in addition to intracellular factors, is proposed to be a crucial mechanism during the progression of invasion...
April 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28236180/supraorbital-subfrontal-trans-laminar-endoscope-assisted-approach-for-tumors-of-the-posterior-third-ventricle
#18
Maurizio Iacoangeli, Roberto Colasanti, Domenic Esposito, Alessandro Di Rienzo, Lucia di Somma, Mauro Dobran, Maurizio Gladi, Massimo Scerrati
BACKGROUND: Different surgical approaches have been developed for dealing with third ventricle lesions, all aimed at obtaining a safe removal minimizing brain manipulation. The supraorbital subfrontal trans-lamina terminalis route, commonly employed only for the anterior third ventricle, could represent, in selected cases with endoscopic assistance, an alternative approach to posterior third ventricular lesions. METHODS: Seven patients underwent a supraorbital subfrontal trans-laminar endoscope-assisted approach to posterior third ventricle tumors (two craniopharyngiomas, one papillary tumor of the pineal region, one pineocytoma, two neurocytomas, one glioblastoma)...
April 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28169411/-factors-related-with-post-surgical-complications-in-elderly-patients-with-glioblastoma-multiforme
#19
M Martin-Risco, V Rodrigo-Paradells, S Olivera-Gonzalez, C M Del Rio-Perez, L Bances-Florez, J B Calatayud-Perez, F J Villagrasa-Compaired
INTRODUCTION: Glioblastoma multiforme is the most frequent malignant tumour of the central nervous system, and its incidence reaches 80% in those over 50 years of age. Life expectancy has increased in the population in recent times and an analysis of the post-surgical complications affecting elderly patients is of great importance for a correct surgical indication. AIMS: To analyse the factors related with post-surgical complications in elderly patients. PATIENTS AND METHODS: A sample of 88 patients diagnosed with glioblastoma multiforme between 31 and 78 years of age was analysed retrospectively...
February 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28005261/results-of-a-multicenter-survey-showing-interindividual-variability-among-neurosurgeons-when-deciding-on-the-radicality-of-surgical-resection-in-glioblastoma-highlight-the-need-for-more-objective-guidelines
#20
J Capellades, P Teixidor, G Villalba, C Hostalot, G Plans, R Armengol, S Medrano, A Estival, R Luque, S Gonzalez, M Gil-Gil, S Villa, J Sepulveda, J J García-Mosquera, C Balana
PURPOSE: We assessed agreement among neurosurgeons on surgical approaches to individual glioblastoma patients and between their approach and those recommended by the topographical staging system described by Shinoda. METHODS: Five neurosurgeons were provided with pre-surgical MRIs of 76 patients. They selected the surgical approach [biopsy, partial resection, or gross total resection (GTR)] that they would recommend for each patient. They were blinded to each other's response and they were told that patients were younger than 50 years old and without symptoms...
June 2017: Clinical & Translational Oncology
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