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Complex ptsd

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https://www.readbyqxmd.com/read/28218249/complexity-variability-assessment-of-nonlinear-time-varying-cardiovascular-control
#1
Gaetano Valenza, Luca Citi, Ronald G Garcia, Jessica Noggle Taylor, Nicola Toschi, Riccardo Barbieri
The application of complex systems theory to physiology and medicine has provided meaningful information about the nonlinear aspects underlying the dynamics of a wide range of biological processes and their disease-related aberrations. However, no studies have investigated whether meaningful information can be extracted by quantifying second-order moments of time-varying cardiovascular complexity. To this extent, we introduce a novel mathematical framework termed complexity variability, in which the variance of instantaneous Lyapunov spectra estimated over time serves as a reference quantifier...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215878/neuroactive-steroids-and-ptsd-treatment
#2
REVIEW
Ann M Rasmusson, Christine E Marx, Suzanne L Pineles, Andrea Locci, Erica R Scioli-Salter, Yael I Nillni, Jennifer J Liang, Graziano Pinna
This review highlights early efforts to translate pre-clinical and clinical findings regarding the role of neuroactive steroids in stress adaptation and PTSD into new therapeutics for PTSD. Numerous studies have demonstrated PTSD-related alterations in resting levels or the reactivity of neuroactive steroids and their targets. These studies also have demonstrated substantial variability in the dysfunction of specific neuroactive steroid systems among PTSD subpopulations. These variabilities have been related to the developmental timing of trauma, severity and type of trauma, genetic background, sex, reproductive state, lifestyle influences such as substance use and exercise, and the presence of comorbid conditions such as depression and chronic pain...
February 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28211592/a-methodology-for-assessing-deployment-trauma-and-its-consequences-in-oef-oif-ond-veterans-the-tracts-longitudinal-prospective-cohort-study
#3
Regina E McGlinchey, William P Milberg, Jennifer R Fonda, Catherine Brawn Fortier
Many US veterans of Afghanistan and Iraq have multiple physical and psychiatric problems. A major focus of research has been on determining the effects of mild Traumatic Brain Injury (mTBI), but mTBI is rarely diagnosed in the absence of co-occurring conditions such as blast exposure, post-traumatic stress disorder (PTSD), depression, substance abuse, etc. These potentially interactive psychological and physical conditions produce complex patterns of cognitive, psychological, and physical symptoms that impede civilian reintegration and complicate efficient and effective treatment planning...
February 17, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28199430/-posttraumatic-stress-disorder-conceptualization-and-psychopharmacological-treatment-update
#4
Leandro N Grendas
Posttraumatic stress disorder (PTSD) is characterized by four symptom complexes: the reexperience/intrusion of the traumatic event, a state of hyperarousal when exposed to traumatic events, emotional block and emotional/affective deregulation with negative cognitive and mood alterations. Its evolution tends to be chronic and its related with a significative morbidity, affecting the functionality of the individual in his interpresonal, social and employment areas. In 1980, the American Psychiatric Association includes PTSD in the third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), and thereafter several research studies are developed to evaluate the effectiveness of drugs on its treatment...
March 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28194504/variation-in-post-traumatic-response-the-role-of-trauma-type-in-predicting-icd-11-ptsd-and-cptsd-symptoms
#5
Philip Hyland, Jamie Murphy, Mark Shevlin, Frédérique Vallières, Eoin McElroy, Ask Elklit, Mogens Christoffersen, Marylène Cloitre
PURPOSE: The World Health Organization's 11th revision to the International Classification of Diseases manual (ICD-11) will differentiate between two stress-related disorders: PTSD and Complex PTSD (CPTSD). ICD-11 proposals suggest that trauma exposure which is prolonged and/or repeated, or consists of multiple forms, that also occurs under circumstances where escape from the trauma is difficult or impossible (e.g., childhood abuse) will confer greater risk for CPTSD as compared to PTSD...
February 14, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28167453/the-role-of-%C3%AE-arrestin-2-on-fear-anxious-related-memory-in-a-rat-model-of-post-traumatic-stress-disorder
#6
Jinlan Ding, Fang Han, Lili Wen, Bing Xiao, Yuxiu Shi
BACKGROUND: Post-traumatic stress disorder (PTSD) can be categorised as a disorder of dysregulated fear processing. In the formation and development of PTSD, whether fear/anxious-related memory is regulated by β-arrestin-2, and happened along the signal transduction pathways remains unknown. METHOD: We used single prolonged stress (SPS) as the animal model of PTSD. Next, elevated plus maze tests (EPM) was performed to examine fear/anxious memory- related behaviors...
January 17, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28161453/rhythms-dysregulation-a-new-perspective-for-understanding-ptsd
#7
Jacques Dayan, Géraldine Rauchs, Bérengère Guillery-Girard
Post-traumatic stress disorder (PTSD) is a complex syndrome that may occur after exposure to one or more traumatic events. It associates physiological, emotional, and cognitive changes Brain and hormonal modifications contribute to some impairments in learning, memory, and emotion regulation. Some of these biological dysfunctions may be analyzed in terms of rhythms dysregulation that would be expressed through endocrine rhythmicity, sleep organization, and temporal synchrony in brain activity. In the first part of this article, we report studies on endocrine rhythmicity revealing that some rhythms abnormalities are frequently observed, although not constantly, for both cortisol and sympathetic nervous system (SNS) activity...
February 1, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28157725/feasibility-of-training-frontline-therapists-in-prolonged-exposure-a-randomized-controlled-pilot-study-of-treatment-of-complex-trauma-in-diverse-victims-of-crime-and-violence
#8
Bita Ghafoori, Marissa C Hansen, Erika Garibay, Olga Korosteleva
The study aims were to determine whether prolonged exposure (PE) improved mental health and was feasible to implement by frontline clinicians in a culturally diverse sample with complex trauma. Seventy-one individuals were randomly assigned to PE or person-centered therapy (PCT). Outcome measures were administered at baseline and sessions 3, 6, 9, and 12. Mixed modeling was used to regress outcome measures on time, treatment group, and number of visits. Individuals who received PE showed significant moderate association with decline in reported posttraumatic stress disorder (PTSD) symptoms as noted by the PTSD Checklist for DSM-5 (p = 0...
February 3, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28146035/community-clinicians-and-the-veterans-choice-program-for-ptsd-care-understanding-provider-interest-during-early-implementation
#9
Erin P Finley, Polly H Noël, Michael Mader, Elizabeth Haro, Nancy Bernardy, Craig S Rosen, Mary Bollinger, Hector Garcia, Kathleen Sherrieb, Mary Jo V Pugh
BACKGROUND: In 2014, the Department of Veterans Affairs (VA) implemented the Veterans Choice Program (VCP) to provide reimbursement for community-based care to eligible veterans. Inadequate networks of participating providers may impact the utility of VCP for veterans with posttraumatic stress disorder (PTSD), a complex condition occurring at lower frequency among civilians. OBJECTIVES: To compare characteristics and attitudes of community-based primary care and mental health providers reporting interest or no interest in VCP participation during early implementation; and to examine perceptions and experiences of VCP among "early adopters...
January 31, 2017: Medical Care
https://www.readbyqxmd.com/read/28145816/a-naturalistic-study-of-a-brief-treatment-program-for-survivors-of-complex-trauma
#10
Catherine C Classen, Robert T Muller, Nigel P Field, Carrie S Clark, Eva-Marie Stern
A naturalistic study of a brief treatment program for The impact of chronic trauma can be longstanding, affecting survivor affect regulation, consciousness, interpersonal functioning, perceptions of self and others, self-regulation, and somatic experience. There is a growing consensus that multi-modal and staged approaches to treatment are necessary to promote healing. However, empirical investigations of such treatments are still needed. The current study used a naturalistic design to examine the impact of a brief, yet intensive, outpatient program on complex PTSD symptoms and attachment classification among women with histories of chronic trauma...
February 1, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28135757/-validation-of-the-german-translation-of-the-revised-trauma-symptom-inventory-tsi-2-to-assess-complex-posttraumatic-stress-symptoms
#11
Sandy Krammer, Heidi Grossenbacher, Nathalie Goldstein, Carole Kaufmann, Alesia Schwenzel, Michael Soyka
The study aimed to validate the German version of the revised Trauma Symptom Inventory (TSI-2) by John Briere. TSI-2 assesses complex posttraumatic stress symptoms. In order to validate it, further instruments were applied, namely the Adverse Childhood Experience Scale, the CIDI list, the revised Impact of Event-Scale, the interview for complex posttraumatic stress disorder, the revised symptom checklist 90, the dissociative experiences scale, the inventory for interpersonal problems, and the self-efficacy questionnaire...
January 30, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28135580/endogenous-cortisol-reactivity-moderates-the-relationship-between-fear-inhibition-to-safety-signals-and-posttraumatic-stress-disorder-symptoms
#12
Daniel V Zuj, Matthew A Palmer, Gin S Malhi, Richard A Bryant, Kim L Felmingham
OBJECTIVE: Posttraumatic stress symptoms (PTSS) are commonly associated with impairments in extinguishing fear to signals previously associated with danger, and also with inhibiting fear to safety signals. Previous studies indicate that PTSS are associated with low cortisol activity, and cortisol is shown to facilitate fear extinction. Few studies have examined the influence of cortisol reactivity on fear extinction in PTSS. METHOD: We used a standardized fear conditioning and extinction paradigm to investigate the relationship between fear extinction and endogenous salivary cortisol activity in participants with high PTSS (n=18), trauma-exposed controls (n=33), and non-trauma-exposed controls (n=27)...
January 16, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28134442/alternative-models-of-disorders-of-traumatic-stress-based-on-the-new-icd-11-proposals
#13
M Shevlin, P Hyland, T Karatzias, C Fyvie, N Roberts, J I Bisson, C R Brewin, M Cloitre
OBJECTIVE: Although there is emerging evidence for the factorial validity of the distinction between post-traumatic stress disorder (PTSD) and complex PTSD (CPTSD) proposed in ICD-11, such evidence has been predominantly based on using selected items from individual scales that describe these factors. We have attempted to address this gap in the literature by testing a range of alternative models of disorders of traumatic stress using a broader range of symptoms and standardized measures...
January 30, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28129565/cannabis-use-disorder-and-suicide-attempts-in-iraq-afghanistan-era-veterans
#14
Nathan A Kimbrel, Amie R Newins, Eric A Dedert, Elizabeth E Van Voorhees, Eric B Elbogen, Jennifer C Naylor, H Ryan Wagner, Mira Brancu, Jean C Beckham, Patrick S Calhoun
The objective of the present research was to examine the association between lifetime cannabis use disorder (CUD), current suicidal ideation, and lifetime history of suicide attempts in a large and diverse sample of Iraq/Afghanistan-era veterans (N = 3233) using a battery of well-validated instruments. As expected, CUD was associated with both current suicidal ideation (OR = 1.683, p = 0.008) and lifetime suicide attempts (OR = 2.306, p < 0.0001), even after accounting for the effects of sex, posttraumatic stress disorder, depression, alcohol use disorder, non-cannabis drug use disorder, history of childhood sexual abuse, and combat exposure...
January 5, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28129257/ptsd-towards-a-patient-level-understanding-of-a-complex-disorder
#15
Gary H Wynn, David M Benedek
No abstract text is available yet for this article.
February 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28114393/altered-microstructural-caudate-integrity-in-posttraumatic-stress-disorder-but-not-traumatic-brain-injury
#16
Dana Waltzman, Salil Soman, Nathan C Hantke, J Kaci Fairchild, Lisa M Kinoshita, Max Wintermark, J Wesson Ashford, Jerome Yesavage, Leanne Williams, Maheen M Adamson, Ansgar J Furst
OBJECTIVE: Given the high prevalence and comorbidity of combat-related PTSD and TBI in Veterans, it is often difficult to disentangle the contributions of each disorder. Examining these pathologies separately may help to understand the neurobiological basis of memory impairment in PTSD and TBI independently of each other. Thus, we investigated whether a) PTSD and TBI are characterized by subcortical structural abnormalities by examining diffusion tensor imaging (DTI) metrics and volume and b) if these abnormalities were specific to PTSD versus TBI...
2017: PloS One
https://www.readbyqxmd.com/read/28097489/enhanced-histone-acetylation-in-the-infralimbic-prefrontal-cortex-is-associated-with-fear-extinction
#17
Sarfraj Ahmad Siddiqui, Sanjay Singh, Vandana Ranjan, Rajesh Ugale, Sudipta Saha, Anand Prakash
The molecular processes that establish fear memory are complex and involve a combination of genetic and epigenetic influences. Dysregulation of these processes can manifest in humans as a range of fear-related anxiety disorders like post-traumatic stress disorders (PTSD). In the present study, immunohistochemistry for acetyl H3, H4, c-fos, CBP (CREB-binding protein) in the infralimbic prefrontal cortex (IL-PFC) and prelimbic prefrontal cortex (PL-PFC) of mPFC (medial prefrontal cortex) and basal amygdala (BA), lateral amygdala (LA), centrolateral amygdala (CeL), centromedial amygdala (CeM) of the amygdala was performed to link region-specific histone acetylation to fear and extinction learning...
January 17, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27996983/-complicated-grief-in-dsm-5-era
#18
Claudia Carmassi, Ciro Conversano, Marialisa Pinori, Carlo Antonio Bertelloni, Riccardo Dalle Luche, Camilla Gesi, Liliana Dell'Osso
An increasing number of data has been recently focused on recognizing pathological grief reactions and on the distinction from physiological processes. Particularly, several studies have supported Complicated Grief (CG) as an independent disorder, in order to define the failure of spontaneous physiological mourning resolution. Upon these studies, the latest edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) with the name of "Persistent Complex Bereavement Disorder". This article aims at retracing the history of clinical research about the physiological and psychopathological processes related to grief and aims at presenting the main scientific studies that have described the features of the CG defining it as a distinct disorder...
November 2016: Rivista di Psichiatria
https://www.readbyqxmd.com/read/27989268/the-factor-structure-of-complex-posttraumatic-stress-disorder-in-traumatized-refugees
#19
Angela Nickerson, Marylene Cloitre, Richard A Bryant, Ulrich Schnyder, Naser Morina, Matthis Schick
BACKGROUND: The construct of complex posttraumatic stress disorder (CPTSD) has attracted much research attention in previous years, however it has not been systematically evaluated in individuals exposed to persecution and displacement. Given that CPTSD has been proposed as a diagnostic category in the ICD-11, it is important that it be examined in refugee groups. OBJECTIVE: In the current study, we proposed to test, for the first time, the factor structure of CPTSD proposed for the ICD-11 in a sample of resettled treatment-seeking refugees...
2016: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/27986702/a-systems-science-approach-to-understanding-polytrauma-and-blast-related-injury-bayesian-network-model-of-data-from-a-survey-of-the-florida-national-guard
#20
Peter A Toyinbo, Rodney D Vanderploeg, Heather G Belanger, Andrea M Spehar, William A Lapcevic, Steven G Scott
We sought to further define the epidemiology of the complex, multiple injuries collectively known as polytrauma/blast-related injury (PT/BRI). Using a systems science approach, we performed Bayesian network modeling to find the most accurate representation of the complex system of PT/BRI and identify key variables for understanding the subsequent effects of blast exposure in a sample of Florida National Guard members (1,443 deployed to Operation Enduring Freedom/Operation Iraqi Freedom and 1,655 not deployed) who completed an online survey during the period from 2009 to 2010...
January 15, 2017: American Journal of Epidemiology
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