keyword
https://read.qxmd.com/read/38492082/pregnancy-in-myasthenia-gravis-a-retrospective-analysis-of-maternal-and-neonatal-outcome-from-a-large-tertiary-care-centre-in-germany
#1
JOURNAL ARTICLE
Jakob Draxler, Andreas Meisel, Frauke Stascheit, Maike Stein, Lea Gerischer, Philipp Mergenthaler, Meret Herdick, Paolo Doksani, Sophie Lehnerer, Stefan Verlohren, Sarah Hoffmann
PURPOSE: Myasthenia gravis (MG) is a rare, potentially life-threatening autoimmune disease with fluctuating muscle weakness frequently affecting women of childbearing age. MG can affect maternal as well as neonatal outcome with risk of worsening of myasthenic symptoms in the mothers and risk of transient neonatal myasthenia gravis (TNMG) and arthrogryposis multiplex congenita (AMC) or foetal acetylcholine receptor antibody-associated disorders (FARAD) in the neonates. METHODS: Retrospective analysis of maternal and neonatal outcome in a cohort of pregnant MG patients treated at a tertiary care centre in Germany...
March 16, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38484218/immune-checkpoint-inhibitor-associated-kelch-like-protein-11-igg-brainstem-encephalitis
#2
JOURNAL ARTICLE
Albert Aboseif, Nisa Vorasoot, Marcus V Pinto, Yong Guo, Shemonti Hasan, Anastasia Zekeridou, John J Chen, Divyanshu Dubey
OBJECTIVES: Kelch-like protein-11 (KLHL11)-IgG is associated with rhombencephalitis and seminoma. It has not previously been described as a neurologic immune checkpoint inhibitor (ICI)-related adverse event (nirAE) or in association with esophageal adenocarcinoma. METHODS: We describe a 61-year-old man with metastatic esophageal adenocarcinoma treated with folinic acid, fluorouracil, oxaliplatin (FOLFOX), and nivolumab, who subsequently developed diplopia, vertigo, and progressive gait ataxia after 8 weeks of treatment...
May 2024: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/38481899/outcomes-of-mechanical-thrombectomy-in-patients-with-neurological-disorders-a-national-inpatient-sample-database-analysis
#3
JOURNAL ARTICLE
Mohammad El-Ghanem, Hael Abdulrazeq, Leonardo Brasiliense, Hamza Abbad, Pedro Aguilar-Salinas, Fawaz Al-Mufti, Travis Dumont
INTRODUCTION: Mechanical thrombectomy (MT) has changed the standard of care for patients presenting with acute ischemic stroke (AIS). The window of treatment has significantly increased the number of patients who would benefit from intervention and operators may be confronted with patients harboring preexistent neurological disorders. Still, the epidemiology of patients with AIS and neurological disorders has not been established. METHODS: This is a retrospective study, which utilizes data from the National Inpatient Sample (NIS) between 2012 and 2016...
February 2024: Curēus
https://read.qxmd.com/read/38481890/the-parallel-world-of-dyspnea-a-case-report
#4
Flávia Baduy, Lenia F Costa, Sofia L Ferreira, Frederico Rocha, Avelina Moniz
Dyspnea can be found as a symptom of a wide range of diseases. Clinical thinking usually leads us to more common or frequent syndromes and diseases. This case report alerts us to keep investigating when faced with therapeutic failure or the arising of new symptoms. The subject in this case had dyspnea as an initial presentation of his disease and was treated initially as a case of heart dysfunction. Nevertheless, because his symptoms did not respond to the treatment and even got worse, he was sent to the emergency room where he was medicated and discharged with the same diagnostic hypothesis...
February 2024: Curēus
https://read.qxmd.com/read/38479127/decision-for-early-tracheostomy-in-respiratory-failure-of-a-paralyzed-myasthenia-gravis-patient-with-sepsis-induced-pneumonia-a-case-report
#5
Resiana Karnina, Adhrie Sugiarto, Rudyanto Sedono, Dita Aditianingsih, Sidharta Kusuma Manggala, Dis Bima Purwaamidjaja
INTRODUCTION: The neuromuscular condition myasthenia gravis (MG) can make treating sepsis-induced pneumonia more challenging. Since these patients risk respiratory failure, decisions about airway treatment, including tracheostomy, can be difficult. We report a case of a patient with sepsis and concurrent MG who underwent an early tracheostomy due to acute respiratory failure. PRESENTATION OF CASE: A 44-year-old woman with a history of MG presented to the emergency department with a stiff tongue, hypersalivation, limb paralysis and a phlegmy cough causing severe respiratory distress, aggravated by community-acquired pneumonia...
March 11, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38478431/literature-commentary
#6
JOURNAL ARTICLE
(no author information available yet)
In this issue of JNO Drs. Mark L. Moster, Marc Dinkin, and Deborah I. Friedman discuss the following six articles.Zhang L, Ouyang S, Chen L, Huang H, Ou Y, Tang X. Evaluation of subjective visual vertical and horizontal in patients with acoustic neuroma based on virtual reality. Front Neurosci. 2023;17:1264585.Westgate CSJ, Kamp-Jensen C, Israelsen IME, et al. Acetazolamide and topiramate lower intracranial pressure through differential mechanisms: The effect of acute and chronic administration. Br J Pharmacol...
March 13, 2024: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://read.qxmd.com/read/38477782/risk-of-fracture-in-patients-with-myasthenia-gravis-a-nationwide-cohort-study-in-korea
#7
JOURNAL ARTICLE
Hye-Sun Park, Kyoungsu Kim, Min Heui Yu, Ha Young Shin, Yumie Rhee, Seung Woo Kim, Namki Hong
Myasthenia gravis (MG) is an autoimmune disorder that affects the neuromuscular junctions, resulting in muscle weakness and fatigue. Muscle weakness, restricted mobility, and frequent use of corticosteroids in patients with MG may predispose them to a higher risk of fractures. However, studies on the impact of MG on bone health and the associated fracture risk are scarce. Utilizing claim database of the Korean National Health Insurance Service collected between 2002 and 2020, we compared the risk of major osteoporotic fracture between 23 118 patients with MG and 115 590 individuals as an age- and sex-matched control group using multivariable Cox proportional hazard models...
March 12, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38476415/myasthenia-gravis-and-numb-chin-syndrome-with-lung-carcinoma
#8
JOURNAL ARTICLE
Rajesh Kumar Gupta, Ashutosh Gupta, Daniel S Um, Zarrin Khameh Neda
No abstract text is available yet for this article.
2024: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/38473397/the-way-ahead-lessons-learned-from-decades-of-cancer-research-on-thymomas-and-thymic-carcinomas
#9
EDITORIAL
Philipp Ströbel, Alexander Marx
The history of thymoma (TH) research begins in the early 20th century, when Bell first recognized the epithelial nature of these tumors and their association with myasthenia gravis (MG) [...].
March 4, 2024: Cancers
https://read.qxmd.com/read/38472974/evaluation-of-sars-cov-2-vaccine-induced-antibody-responses-in-patients-with-neuroimmunological-disorders-a-real-world-experience
#10
JOURNAL ARTICLE
Hyunjin Ju, Jin Myoung Seok, Yeon Hak Chung, Mi Young Jeon, Hye Lim Lee, Soonwook Kwon, Sunyoung Kim, Ju-Hong Min, Byoung Joon Kim
This study evaluates the antibody responses to SARS-CoV-2 vaccines in patients with neuroimmunological disorders (pwNID) who are receiving immunomodulating treatments, compared to healthy individuals. It included 25 pwNID with conditions such as optic neuritis, neuromyelitis optica spectrum disorder, multiple sclerosis, myasthenia gravis, and polymyositis, as well as 56 healthy controls. All participants had completed their full SARS-CoV-2 vaccination schedule, and their blood samples were collected within six months of their last dose...
February 26, 2024: Diagnostics
https://read.qxmd.com/read/38469587/identifying-patients-at-risk-for-myasthenic-crisis-with-hemogram-and-inflammation-related-laboratory-parameters-a-pilot-study
#11
JOURNAL ARTICLE
Anne Mehnert, Sivan Bershan, Jil Kollmus-Heege, Lea Gerischer, Meret Luise Herdick, Sarah Hoffmann, Sophie Lehnerer, Franziska Scheibe, Frauke Stascheit, Maike Stein, Alastair M Buchan, Andreas Meisel, Annette Aigner, Philipp Mergenthaler
BACKGROUND: Myasthenia gravis (MG) is a rare autoimmune disease characterized by fatigable weakness of the voluntary muscles and can exacerbate to life-threatening myasthenic crisis (MC), requiring intensive care treatment. Routine laboratory parameters are a cost-effective and widely available method for estimating the clinical outcomes of several diseases, but so far, such parameters have not been established to detect disease progression in MG. METHODS: We conducted a retrospective analysis of selected laboratory parameters related to inflammation and hemogram for MG patients with MC compared to MG patients without MC...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38466015/neurological-autoimmunity-in-patients-with-non-pulmonary-neuroendocrine-neoplasms-clinical-manifestations-and-neural-autoantibody-profiles
#12
JOURNAL ARTICLE
Georgios Mangioris, Thorvardur R Halfdanarson, Vanda A Lennon, Bryce K Chang, Divyanshu Dubey, P James B Dyck, Eoin P Flanagan, Andrew McKeon, John R Mills, Sean J Pittock, Anastasia Zekeridou
BACKGROUND AND PURPOSE: Paraneoplastic neurological autoimmunity is well described with small-cell lung cancer, but information is limited for other neuroendocrine neoplasms (NENs). METHODS: Adult patients with histopathologically confirmed non-pulmonary NENs, neurological autoimmunity within 5 years of NEN diagnosis, and neural antibody testing performed at the Mayo Clinic Neuroimmunology Laboratory (January 2008 to March 2023) were retrospectively identified...
March 11, 2024: European Journal of Neurology
https://read.qxmd.com/read/38463080/myasthenic-crisis-induced-takotsubo-cardiomyopathy-a-case-report
#13
Janak Khadka, Pravesh Bhattarai, Apsara Adhikari, Rajat Acharya, Parash Rayamajhi
INTRODUCTION AND IMPORTANCE: Myasthenic crisis (MC) is characterized by severe weakness in the bulbar and respiratory muscles. Takotsubo cardiomyopathy (TC) is a rare clinical entity mainly associated with postmenopausal women. We report a case of both these conditions in a premenopausal woman. CASE PRESENTATION: A 31-year-old woman with hypothyroidism presented with dyspnea. Bedside echocardiography in the ICU revealed an apical ballooning with an ejection fraction of 25%, and she was treated with losartan, furosemide, and spironolactone...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38458542/current-state-of-research-on-exercise-for-the-treatment-of-myasthenia-gravis-a-scoping-review
#14
REVIEW
Siyang Peng, Linghao Meng, Ruiying Fang, Qiqi Shen, Yukun Tian, Anni Xiong, Shaohong Li, Yajing Yang, Weiqian Chang, Jinxia Ni, Wenzeng Zhu
OBJECTIVE: To provide a comprehensive overview of existing evidence, research gaps, and future research priorities concerning the treatment of myasthenia gravis (MG) using exercise therapies. METHOD: Clinical studies on exercise treatment for MG were searched in nine databases to conduct a scoping review. Two independent researchers screened the literature and comprehensively analyzed the characteristics and limitations of the included articles. RESULTS: A total of 5725 studies were retrieved, of which 24 were included...
March 6, 2024: Complementary Therapies in Medicine
https://read.qxmd.com/read/38456240/epidemiology-of-seropositive-myasthenia-gravis-in-sardinia-a-population-based-study-in-the-district-of-sassari
#15
JOURNAL ARTICLE
Elia Sechi, Giovanni A Deiana, Mariangela Puci, Pietro Zara, Enzo Ortu, Caterina Porcu, Nicola Carboni, Paola Chessa, Elisa Ruiu, Arianna Nieddu, Paolo Tacconi, Antonello Russo, Davide Manca, M Margherita Sechi, Melania Guida, Roberta Ricciardi, Tommaso Ercoli, Marcello M Mascia, Antonella Muroni, Paolo Profice, Valeria Saddi, Maurizio Melis, Eleonora Cocco, Gregorio Spagni, Raffaele Iorio, Valentina Damato, Michelangelo Maestri, Stefano Sotgiu, Giovanni Sotgiu, Paolo Solla
INTRODUCTION/AIMS: The global incidence and prevalence of myasthenia gravis (MG) range between 6-31/million and 10-37/100,000, respectively. Sardinia is a high-risk region for different immune-mediated disorders, but the epidemiology of MG remains unclear. We determined the epidemiology of MG with acetylcholine receptor (AChR)-immunoglobulin G (IgG) and muscle-specific tyrosine kinase (MuSK)-IgG in the district of Sassari (North-Western Sardinia; population, 325,288). METHODS: From the laboratory of the University Hospital of Sassari (reference for AChR/MuSK-IgG testing in Sardinia since 1998) and the main neurology units in Sardinia, we retrospectively identified MG patients with (1) AChR-IgG and/or MuSK-IgG positivity by radioimmunoprecipitation assay; and (2) residency in the district of Sassari...
March 8, 2024: Muscle & Nerve
https://read.qxmd.com/read/38455056/a-case-of-igg4-related-ophthalmic-disease-after-sars-cov-2-vaccination-case-report-and-literature-review
#16
REVIEW
Peixuan Zhang, Qian Wu, Xiao Xu, Minliang Chen
Coronavirus disease 19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is affecting the world with a surge in cases. A variety of autoimmune diseases occur after SARS-CoV-2 infection or vaccination, of which IgG4-related disease (IgG4-RD) is an important type. IgG4-RD can involve multiple organs of the body. The ocular manifestation of IgG4-RD is called IgG4-related ophthalmic disease (IgG4-ROD). We herein report a patient diagnosed with IgG4-ROD. The patient developed ptosis and vision loss after SARS-CoV-2 vaccination, and the symptoms worsened after SARS-CoV-2 infection...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38450071/case-report-resolution-of-guillain-barr%C3%A3-syndrome-in-a-patient-with-dual-primary-tumors-after-treatment-with-rituximab
#17
Desheng Zhang, You Wang, Fuxiang Zhou
Guillain-Barré syndrome (GBS) is a rare immune-related adverse event (irAE) that can occur in solid tumors such as hepatocellular carcinoma, gastric cancer, breast cancer, and colorectal cancer. It is characterized by progressive myasthenia and mild sensory abnormalities. The emergence of immune checkpoint inhibitors (ICIs) has significantly improved cancer patients' life expectancy but can also trigger various irAEs, including GBS. We report a rare case of GBS in a 64-year-old male patient with dual primary tumors of the colon and stomach who received toripalimab and chemotherapy for liver metastases...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38449651/causal-relationship-between-the-immune-phenotype-of-monocytes-and-myasthenia-gravis-a-mendelian-randomization-study
#18
JOURNAL ARTICLE
Jing Dong, Rui-Sheng Duan, Peng Zhang
BACKGROUND: Monocytes play an essential role in developing autoimmune diseases; however, their association with myasthenia gravis (MG) development is unclear. METHODS: We performed a two-sample Mendelian randomization analysis to assess the causal relationship between monocyte-associated traits and MG, reviewing summary statistics of genome-wide association studies (GWAS). RESULTS: Using the inverse variance weighted method, the following were found to be causally associated with MG: HLA-DR on monocytes (OR, 1...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38449066/small-extracellular-vesicle-micrornas-in-pediatric-myasthenia-gravis-plasma-and-skeletal-muscle
#19
JOURNAL ARTICLE
Mengying Zhu, Yilong Wang, Xuebin Xu, Xiaotong Guo, Yuchen Mao, Feng Gao
BACKGROUND: The diagnosis of myasthenia gravis (MG) in children remains difficult. Circulating small extracellular vesicle (sEV)-derived miRNAs (sEV-miRNAs) have been recognized as biomarkers of various diseases and can be excreted by different cell types. These biomarker candidates also play a vital role in autoimmune diseases via intercellular communication. METHODS: In the present study, we used sEV isolation and purification methods to extract the plasma-derived sEV-miRNAs from children with MG and healthy controls...
March 6, 2024: Postgraduate Medical Journal
https://read.qxmd.com/read/38448176/-diaphragmatic-dysfunction-post-covid-19-infection-report-of-two-cases
#20
REVIEW
D Yu, W Q Huang, Y Z Zhan, G H Xiao, J Li, W C Tong, S X Cai, L Y Liu
Following the global outbreak of COVID-19, many patients have suffered from multi-system complications and long-term sequelae caused by the virus. Diaphragm dysfunction is an obscure post-COVID-19 symptom. Although a few cases of diaphragm dysfunction caused by COVID-19 infection have been reported abroad, there are no relevant reports in China. Herein, we present two cases of patients with respiratory distress after COVID-19 infection. On admission, dynamic chest radiographs revealed diaphragm dysfunction in these patients...
March 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
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