Martin Skov, Titia Q Ruijs, Thomas S Grønnebæk, Marianne Skals, Anders Riisager, Jeppe Blichfeldt Winther, Kamilla Løhde Tordrup Dybdahl, Anders Findsen, Jeanette J Morgen, Nete Huus, Martin Broch-Lips, Ole B Nielsen, Catherine M K E de Cuba, Jules A A C Heuberger, Marieke L de Kam, Martijn Tannemaat, Jan J G M Verschuuren, Lars J S Knutsen, Nicholas M Kelly, Klaus G Jensen, William D Arnold, Arthur H Burghes, Claus Olesen, Jane Bold, Thomas K Petersen, Jorge A Quiroz, John Hutchison, Eva R Chin, Geert J Groeneveld, Thomas H Pedersen
Myasthenia gravis (MG) is a neuromuscular disease that results in compromised transmission of electrical signals at the neuromuscular junction (NMJ) from motor neurons to skeletal muscle fibers. As a result, patients with MG have reduced skeletal muscle function and present with symptoms of severe muscle weakness and fatigue. ClC-1 is a skeletal muscle specific chloride (Cl- ) ion channel that plays important roles in regulating neuromuscular transmission and muscle fiber excitability during intense exercise...
March 20, 2024: Science Translational Medicine