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https://www.readbyqxmd.com/read/27918443/human-intervention-study-to-assess-the-effects-of-supplementation-with-olive-leaf-extract-on-peripheral-blood-mononuclear-cell-gene-expression
#1
Anna Boss, Chi Hsiu-Juei Kao, Pamela M Murray, Gareth Marlow, Matthew P G Barnett, Lynnette R Ferguson
Olive leaf extract (OLE) has been used for many years for its putative health benefits, but, to date, scientific evidence for the basis of these effects has been weak. Although recent literature has described a link between ailments such as cardiovascular disease, diabetes and cancer and a protective effect of polyphenols in the OLE, the mode of action is still unclear. Here, we describe a double-blinded placebo (PBO)-controlled trial, in which gene expression profiles of peripheral blood mononuclear cells from healthy male volunteers (n = 29) were analysed to identify genes that responded to OLE, following an eight-week intervention with 20 mL daily consumption of either OLE or PBO...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27916487/evaluation-of-hepatoprotective-potential-of-erythrina-indica-leaves-against-antitubercular-drugs-induced-hepatotoxicity-in-experimental-rats
#2
Mohd Mujahid, Talib Hussain, Hefazat Hussain Siddiqui, Arshad Hussain
BACKGROUND: Erythrina indica Lam. traditionally used in the treatment of laxative, diuretic, worm infestation, liver ailment and joints pain. OBJECTIVE: To evaluate the antihepatotoxic potential of Erythrina indica against isoniazid (INH) and rifampicin (RIF) induced hepatotoxicity in rats. METHODS AND MATERIAL: Liver toxicity was induced by antitubercular drugs (INH+ RIF) at dose level of 50 mg/kg each, p.o for 28 days. 50% methanolic extract of Erythrina indica (100 and 200 mg/kg) were administered orally once daily for 28 days...
December 1, 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27915437/selective-reliable-blood-and-milk-bio-markers-for-diagnosing-clinical-and-subclinical-bovine-mastitis
#3
Kadry Sadek, Ebeed Saleh, Mousa Ayoub
Mastitis is positioned as the most vital ailment in dairy cows in light of conventional cost examinations. The aim of the present study was to evaluate the diagnostic value of different acute phase proteins (APPs), pro-inflammatory cytokines, and oxidative stress biomarkers in healthy cows and in those with clinical or subclinical mastitis and to localize APP gene expression in the milk of mastitic cows. Therefore, 20 subclinical mastitic cows with positive California Mastitis Test (CMT) results and no clinical signs of mastitis, 15 clinically mastitic cows, and 15 healthy cows with negative CMT results and somatic cell count (SCC) of <600,000 cells/mL were selected...
December 3, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27905920/synergistic-effects-and-related-bioactive-mechanism-of-potentilla-fruticosa-l-leaves-combined-with-ginkgo-biloba-extracts-studied-with-microbial-test-system-mts
#4
Ze-Hua Liu, Dong-Mei Wang, Su-Fang Fan, Deng-Wu Li, Zi-Wen Luo
BACKGROUND: Potentilla fruticosa, also called "Jinlaomei" and "Gesanghua", is widely used as folk herbs in traditional Tibetan medicine in China to treat inflammations, wounds, certain forms of cancer, diarrhoea, diabetes and other ailments. Previous research found P. fruticosa leaf extract (C-3) combined with Ginkgo biloba extracts (EGb) showed obvious synergistic effects in a variety of oxidation systems. The aim of the present study was to further confirm the synergy of P. fruticosa combined with EGb viewed from physiological bioavailability and explore the related bioactive mechanism behind the synergism...
December 1, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27905503/advancing-ovarian-folliculometry-with-selective-plane-illumination-microscopy
#5
Hsiao-Chun Amy Lin, Rahul Dutta, Subhamoy Mandal, Alexander Kind, Angelika Schnieke, Daniel Razansky
Determination of ovarian status and follicle monitoring are common methods of diagnosing female infertility. We evaluated the suitability of selective plane illumination microscopy (SPIM) for the study of ovarian follicles. The large field of view and fast acquisition speed of our SPIM system enables rendering of volumetric image stacks from intact whole porcine ovarian follicles, clearly visualizing follicular features including follicle volume and average diameter (70 μm-2.5 mm), their spherical asymmetry parameters, size of developing cumulus oophorus complexes (40 μm-110 μm), and follicular wall thickness (90 μm-120 μm)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900276/foreign-body-in-duodenum-mimicking-a-duplication-cyst-on-imaging
#6
Aditya Pratap Singh, Vinay Mathur, Ramesh Tanger, Arun Gupta, Ayush Kumar
Paediatric age group is most vulnerable for the accidental foreign body (FB) ingestion which may go unnoticed. These patients present with symptoms or complications as a result of FB and may mimic other conditions on various investigations. We describe a 9-month old infant who ingested crystal gel ball and presented with vomiting for a month. On radiological imaging it was interpreted as duplication cyst of the duodenum. At operation, crystal gel ball was retrieved. Our case vindicates importance of keeping various possibilities in mind as differential diagnoses during evaluation and management of surgical ailments such as the duplication cyst of duodenum...
November 2016: APSP Journal of Case Reports
https://www.readbyqxmd.com/read/27899097/antinociception-of-petroleum-ether-fraction-derived-from-crude-methanol-extract-of-melastoma-malabathricum-leaves-and-its-possible-mechanisms-of-action-in-animal-models
#7
Z A Zakaria, E S Jaios, M H Omar, S Abd Rahman, S S A Hamid, S M Ching, L K Teh, M Z Salleh, S Deny, M Taher
BACKGROUND: Melastoma malabathricum L. (family Melastomaceae) has been traditionally used as remedies against various ailments including those related to pain. The methanol extract of M. malabathricum leaves has been proven to show antinociceptive activity. Thus, the present study aimed to determine the most effective fraction among the petroleum ether- (PEMM), ethyl acetate- (EAMM) and aqueous- (AQMM) fractions obtained through successive fractionation of crude, dried methanol extract of M...
November 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27898350/cronkhite-canada-syndrome-complicated-by-pulmonary-embolism-a-case-report
#8
Neha L Nemade, Urvi B Shukla, Gajanan D Wagholikar
INTRODUCTION: Cronkhite Canada Syndrome (CCS) is a rare syndrome, described in 1955 by Americans, Leonard Wolsey Cronkhite and Wilma Jeanne Canada in the New England Journal of Medicine [1]. About 450 cases have been reported. Complications, like malignant transformation, unprovoked thromboembolism is known. Since there is wide variability in medical presentation, no definitive diagnostic and treatment protocol s have been set. The mortality remains at 55%. CASE PRESENTATION: We report a case of a 50 year old male patient presenting with diarrhea, weight loss, abdominal pain, ectodermal features...
November 17, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27897111/aggressive-antioxidant-reductive-stress-impairs-brain-endothelial-cell-angiogenesis-and-blood-brain-barrier-function
#9
Shireen Mentor, David Fisher
Oxidative stress in the brain microvasculature is a common characteristic in models of cerebrovascular disease. Considering the effects of reactive oxygen species activity in vascular-derived insults, it is naturally prudent to hypothesize those interventions inhibiting reactive oxygen species activity, such as antioxidant supplementation, may be beneficial for cerebrovascular disease. Hyper doses of antioxidant supplements, and foods with high antioxidant concentrations, are commonly used as an ongoing remedial and 'over-the-counter' treatments for most seasonal ailments...
November 29, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27891018/legal-challenges-in-neurological-practice
#10
REVIEW
Sita Jayalakshmi, Sudhindra Vooturi
Clinical neuroscience has made tremendous advances over the last century. Neurology as a discipline is still considered challenging and at times risky due to the natural history and progressive course of few of the neurological diseases. Encouragingly, the patient and their caregivers are now increasingly willing to be actively involved in making decisions. The patients' relationship with the doctor is a reflection of the society. A society that is orienting itself toward "rating" and "feedback" has made this doctor-patient relationship, a consumer-service provider relationship...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27881119/antibacterial-and-antifungal-potentials-of-the-solvents-extracts-from-eryngium-caeruleum-notholirion-thomsonianum-and-allium-consanguineum
#11
Abdul Sadiq, Sadiq Ahmad, Rahmat Ali, Fawad Ahmad, Sajjad Ahmad, Anwar Zeb, Muhammad Ayaz, Farhat Ullah, Abu Nasar Siddique
BACKGROUND: Herbal medicines have long been used for various ailments in various societies and natural bioactive compounds are gaining more and more importance due to various factors. In this context, three plant species i.e., Eryngium caeruleum, Notholirion thomsonianum and Allium consanguineum have been aimed for the scientific verification of their purported traditional uses against various infectious diseases. METHODS: In this study, three plants were assayed for antibacterial and antifungal potentials...
November 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27878782/trajectory-of-cause-of-death-among-brought-dead-neonates-in-tertiary-care-public-facilities-of-pakistan-a-multicenter-study
#12
Muhammad Ayaz Mustufa, Munir Ahmed Sheikh, Ijaz-Ul-Haque Taseer, Syed Jamal Raza, Muhammad Sohail Arshad, Tasleem Akhter, Ghazala Mohyuddin Arain, Sultana Habibullah, Sohail Safdar, Rukhsana Firdous, Muhammad Adnan
BACKGROUND: Considering the fact that Pakistan is amongst the countries with very high neonatal mortality rates, we conducted a research study to determine the possible causes and characteristics of neonates presenting dead to the emergency department of tertiary public health care facilities of Pakistan using verbal autopsies. METHODS: A descriptive case series study was conducted in emergency department/pediatrics ward/neonatal ward/nursery unit of ten tertiary care public health facilities, situated in seven major cities of Pakistan from November, 2011 to June, 2013...
November 23, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27878530/gendered-medicinal-plant-knowledge-contributions-to-adaptive-capacity-and-health-sovereignty-in-amazonia
#13
Isabel Díaz-Reviriego, Álvaro Fernández-Llamazares, Matthieu Salpeteur, Patricia L Howard, Victoria Reyes-García
Local medical systems are key elements of social-ecological systems as they provide culturally appropriate and locally accessible health care options, especially for populations with scarce access to biomedicine. The adaptive capacity of local medical systems generally rests on two pillars: species diversity and a robust local knowledge system, both threatened by local and global environmental change. We first present a conceptual framework to guide the assessment of knowledge diversity and redundancy in local medicinal knowledge systems through a gender lens...
December 2016: Ambio
https://www.readbyqxmd.com/read/27870082/a-proposal-to-address-nfl-club-doctors-conflicts-of-interest-and-to-promote-player-trust
#14
I Glenn Cohen, Holly Fernandez Lynch, Christopher R Deubert
How can we ensure that players in the National Football League receive excellent health care they can trust from providers who are as free from conflicts of interest as realistically possible? NFL players typically receive care from the club's own medical staff. Club doctors are clearly important stakeholders in player health. They diagnose and treat players for a variety of ailments, physical and mental, while making recommendations to the player concerning those ailments. At the same time, club doctors have obligations to the club, namely to inform and advise clubs about the health status of players...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27867265/alpha-glucosidase-inhibitory-and-antioxidant-potential-of-antidiabetic-herb-alternanthera-sessilis-comparative-analyses-of-leaf-and-callus-solvent-fractions
#15
Tsun-Thai Chai, Chee-Siong Khoo, Chong-Siang Tee, Fai-Chu Wong
BACKGROUND: Alternanthera sessilis is a medicinal herb which is consumed as vegetable and used as traditional remedies of various ailments in Asia and Africa. OBJECTIVE: This study aimed to investigate the antiglucosidase and antioxidant activity of solvent fractions of A. sessilis leaf and callus. MATERIALS AND METHODS: Leaf and callus methanol extracts were fractionated to produce hexane, chloroform, ethyl acetate, butanol, and water fractions...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27864111/secondary-metabolites-from-tetracera-potatoria-stem-bark-with-anti-mycobacterial-activity
#16
McY Fomogne-Fodjo, D T Ndinteh, D K Olivier, P Kempgens, S van Vuuren, Rwm Krause
ETHNOPHARMACOLOGICAL RELEVANCE: Tetracera potatoria Afzel.Exg.Don (Dilleniaceae) is a medicinal plant used traditionally in Africa for the treatment of tuberculosis related ailments and respiratory infections. The antibacterial activity of the medium polar extracts of T. potatoria leaves and stem bark was recently reported against Mycobacterium smegmatis (MIC 25µg/mL) and M. aurum (65µg/mL), two fast-growing Mycobacterium strains used as model micro-organisms for the more pathogenic strain Mycobacterium tuberculosis (Fomodje-Fodjo et al...
November 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27859564/excess-mortality-in-the-myelodysplastic-syndromes
#17
Meritxell Nomdedeu, Arturo Pereira, Fernando Ramos, David Valcárcel, Dolors Costa, Montserrat Arnan, Xavier Calvo, Helena Pomares, Elisa Luño, María Díaz-Campelo, Rosa Collado, Raquel de Paz, José-Francisco Falantes, Carme Pedro, Josefa Marco, Itziar Oirtzabal, Joaquín Sánchez-García, Mar Tormo, María-Teresa Cedena, Benet Nomdedeu, Guillermo Sanz
Myelodysplastic syndromes (MDS) are the commonest hematologic malignancies in the elderly. Since many patients with MDS actually die from age-related ailments, the very disease burden of MDS remains largely unknown. This registry-based study was aimed at investigating the excess mortality attributable to MDS. We analyzed 7,408 adult patients diagnosed with primary MDS from 1980 to 2014. Excess mortality was estimated by comparing the patients' survival with that expected in the matched general population. Median age of patients was 74 years, 58% were males, and 65% belonged to the lower risk categories of the Revised International Prognostic Scoring System (IPSS-R)...
November 14, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27853338/primary-enterolith-in-a-patient-with-intestinal-tuberculosis-a-case-report
#18
Mohd Habib Raza, RafiulImad Finan, Sadik Akhtar, Manzoor Ahmad
Primary enterolithiasis is a rare surgical ailment. The underlying cause is intestinal stasis. Numerous anatomical and micro environmental factors such as enteritis, incarcerated hernia, malignancy, diverticula, blind loops, and enteroenterostomy predispose to clinically significant concretions. Enterolithiasis in tuberculosis can be due to the presence of strictures, intestinal bands, or interbowel/parietal adhesions, leading to intestinal stasis. Secondary enterolithiasis is generally caused by gallstones or renal stones migrating to the gastrointestinal tract due to fistula formation...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27852338/determinants-of-dietary-patterns-and-diet-quality-during-pregnancy-a-systematic-review-with-narrative-synthesis
#19
Ina-Merle Doyle, Brigitte Borrmann, Angelique Grosser, Oliver Razum, Jacob Spallek
OBJECTIVE: To identify determinants of diet in pregnancy, by detecting factors in our multiple-determinants life course framework that are associated with dietary patterns, quality or guideline adherence. DESIGN: A systematic review of observational studies, published in English or German, was conducted. Sociodemographic, lifestyle, environmental and pregnancy-related determinants were considered. Four electronic databases were searched in January 2015 and updated in April 2016 and a total of 4368 articles identified...
November 17, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27848096/the-gut-kidney-axis
#20
REVIEW
Pieter Evenepoel, Ruben Poesen, Björn Meijers
The host-gut microbiota interaction has been the focus of increasing interest in recent years. It has been determined that this complex interaction is not only essential to many aspects of normal "mammalian" physiology but that it may also contribute to a multitude of ailments, from the obvious case of inflammatory bowel disease to (complex) diseases residing in organs outside the gut. An increasing body of evidence indicates that crosstalk between host and microbiota is pathophysiologically relevant in patients with chronic kidney disease (CKD)...
November 15, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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