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https://www.readbyqxmd.com/read/28213108/intestinal-transport-and-absorption-of-bioactive-phenolic-compounds-from-a-chemically-characterized-aqueous-extract-of-athrixia-phylicoides
#1
Sandra L Bowles, Yonela Ntamo, Christiaan J Malherbe, Abidemi M P Kappo, Johan Louw, Christo J F Muller
ETHNOPHARMACOLOGICAL RELEVANCE: Athrixia phylicoides (A. phylicoides), popularly known as "bush tea", is an indigenous aromatic shrub found in mountainous and grassland areas of the northern and eastern parts of southern Africa. The plant is traditionally used for the treatment of several ailments, including coughing, treating infected wounds, treating boils and sore throat, hypertension and heart disease. Potential anti-diabetic effects have also been demonstrated in vitro. AIM OF THE STUDY: To investigate the intestinal transport of prominent phenolic constituents, across a fully differentiated Caco-2 monolayer, using a characterized aqueous extract of A...
February 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28212288/the-search-for-dietary-supplements-to-elevate-or-activate-circulating-paraoxonases
#2
REVIEW
José M Lou-Bonafonte, Clara Gabás-Rivera, María A Navarro, Jesús Osada
Low levels of paraoxonase 1 (PON1) have been associated with the development of several pathological conditions, whereas high levels have been shown to be anti-atherosclerotic in mouse models. These findings suggest that PON1 could be a good surrogate biomarker. The other members of the family, namely PON2 and PON3, the role of which has been much less studied, deserve more attention. This paper provides a systematic review of current evidence concerning dietary supplements in that regard. Preliminary studies indicate that the response to dietary supplements may have a nutrigenetic aspect that will need to be considered in large population studies or in clinical trials...
February 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28209080/antispasmodic-and-bronchorelaxant-activities-of-salsola-imbricata-are-mediated-through-dual-ca-2-antagonistic-and-%C3%AE-adrenergic-agonistic-effects
#3
Naveed Aslam, Khalid Hussain Janbaz
CONTEXT: Salsola imbricata Forssk. (Chenopodiaceae) has folkloric repute for the treatment of various gastrointestinal and respiratory ailments. OBJECTIVE: The present study investigates spasmolytic and bronchorelaxant effects of S. imbricata. MATERIALS AND METHODS: The crude aqueous-ethanol extract of the aerial parts of S. imbricata and its fractions, in cumulative concentrations (0.01-10 mg/mL), were tested on contractions of isolated rabbit jejunum and tracheal preparations...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28208599/medical%C3%A2-yoga%C3%A2-therapy
#4
REVIEW
Ina Stephens
Medical yoga is defined as the use of yoga practices for the prevention and treatment of  medical conditions. Beyond the physical elements of yoga, which are important and effective for  strengthening  the  body,  medical  yoga  also  incorporates  appropriate  breathing  techniques,  mindfulness, and meditation in order to achieve the maximum benefits. Multiple studies have  shown that yoga can positively impact the body in many ways, including helping to regulate blood  glucose levels, improve musculoskeletal ailments and keeping the cardiovascular system in tune...
February 10, 2017: Children
https://www.readbyqxmd.com/read/28203134/black-cohosh-hepatotoxicity-with-autoimmune-hepatitis-presentation
#5
Diana L Franco, Santosh Kale, Dora M Lam-Himlin, M Edwyn Harrison
Herbal medicines have been used for the treatment of various ailments since time immemorial. Black cohosh (BC) is well known for the treatment of postmenopausal symptoms, with conflicting evidence supporting its safety and benefits. We present a rare case of BC-induced autoimmune hepatitis (AIH) with hepatotoxicity in a 69-year-old female. To our knowledge, this represents the third case of BC-induced AIH.
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28198202/clinacanthus-nutans-a-review-on-ethnomedicinal-uses-chemical-constituents-and-pharmacological-properties
#6
Ihsan N Zulkipli, Rajan Rajabalaya, Adi Idris, Nurul Atiqah Sulaiman, Sheba R David
CONTEXT: Medicinal plants have attracted global attention for their hidden therapeutic potential. Clinacanthus nutans (Burm.f) Lindau (Acanthaceae) (CN) is endemic in Southeast Asia. CN contains phytochemicals common to medicinal plants, such as flavonoids. Traditionally, CN has been used for a broad range of human ailments including snake bites and cancer. OBJECTIVES: This article compiles the ethnomedicinal uses of CN and its phytochemistry, and thus provides a phytochemical library of CN...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28198069/ultrapulse-carbon-dioxide-laser-treatment-for-bilateral-facial-nevus-comedonicus-a-case-report
#7
Caiyong Zhu, Aijuan Sun
Nevus comedonicus (NC), a rare skin ailment with an aggregation of dilated follicular orifices filled with keratinous material, is difficult to treat. Several drugs have been assessed for the treatment of NC, but with limited success. Surgery requires much experience and the recurrence rate is high. Various types of laser have been tried, with promising outcomes. A 54-year-old male patient with bilateral facial NC was admitted on July 8, 2014. A coin-sized area was first treated successfully with ultrapulse CO2 laser...
February 15, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28197985/inonotus-obliquus-polysaccharide-regulates-gut-microbiota-of-chronic-pancreatitis-in-mice
#8
Yang Hu, Chunying Teng, Sumei Yu, Xin Wang, Jinsong Liang, Xin Bai, Liying Dong, Tao Song, Min Yu, Juanjuan Qu
Polysaccharide is efficient in attenuation of metabolic ailments and modulation of gut microbiota as prebiotics. The therapeutic effect of Inonotus obliquus polysaccharide (IOP) on chronic pancreatitis (CP) in mice has been validated in our previous study. However, it is not clear whether IOP is conducive to maintaining the homeostasis between gut microbiota and host. The aim of this study is to testify the potential effects of IOP on gut microbiota composition and diversity in mice with CP. The changes in glutathione peroxidase (GSH-PX), total antioxidant capacity (TAOC), tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β), lipase and trypsin levels were measured by commercial assay kits, meanwhile the gut microbiota composition and diversity were analyzed by high throughput sequencing...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28197922/coordination-of-cellular-localization-dependent-effects-of-sumoylation-in-regulating-cardiovascular-and-neurological-diseases
#9
Jun-Ichi Abe, Uday G Sandhu, Nguyet Minh Hoang, Manoj Thangam, Raymundo A Quintana-Quezada, Keigi Fujiwara, Nhat Tu Le
Sumoylation, a reversible post-transcriptional modification process, of proteins are involved in cellular differentiation, growth, and even motility by regulating various protein functions. Sumoylation is not limited to cytosolic proteins as recent evidence shows that nuclear proteins, those associated with membranes, and mitochondrial proteins are also sumoylated. Moreover, it is now known that sumoylation plays an important role in the process of major human ailments such as malignant, cardiovascular and neurological diseases...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28196999/indian-psychiatric-society-multicentric-study-correlates-of-prescription-patterns-of-psychotropics-in-india
#10
Sandeep Grover, Ajit Avasthi, Vishal Sinha, Bhavesh Lakdawala, Manish Bathla, Sujata Sethi, D M Mathur, Puneet Kathuria, Sandip Shah, D Sai Baalasubramanian, Vivek Agarwal, Kamla Deka
BACKGROUND: There is a lack of information on the clinical and sociodemographic correlates of prescription of psychotropics by psychiatrists. AIM AND OBJECTIVE: This study aimed to evaluate the relationship of prescription patterns with various clinical and sociodemographic variables. METHODOLOGY: Data of prescription patterns, psychiatric diagnosis, sociodemographic variables, and comorbid physical illnesses were collected for 4480 patients, across 11 centers...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28191530/contrast-enhanced-ultrasound-a-promising-method-for-renal-microvascular-perfusion-evaluation
#11
REVIEW
Ling Wang, Chandra Mohan
This article reviews the application of contrast-enhanced ultrasound (CEUS) in gauging renal microvascular perfusion in diverse renal diseases. The unique nature of the contrast agents used in CEUS provides real-time and quantitative imaging of the vasculature. In addition to the traditional use of CEUS for evaluation of kidney masses, it also emerges as a safe and effective imaging approach to assess microvascular perfusion in diffuse renal lesions, non-invasively. Although the precise CEUS parameters that may best predict disease still warrant systematic evaluation, animal models and limited clinical trials in humans raise hopes that CEUS could outcompete competing modalities as a first-line tool for assessing renal perfusion non-invasively, even in ailments such as acute kidney injury and chronic kidney disease...
September 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28190465/butein-in-health-and-disease-a-comprehensive-review
#12
REVIEW
Ganesan Padmavathi, Nand Kishor Roy, Devivasha Bordoloi, Frank Arfuso, Srishti Mishra, Gautam Sethi, Anupam Bishayee, Ajaikumar B Kunnumakkara
BACKGROUND: The risk of suffering from many chronic diseases seems to have made no improvement despite the advancement in medications available in the modern world. Moreover, the use of synthetic chemicals as medications has proved to worsen the scenario due to the various adverse side effects associated with them. PURPOSE: Extensive research on natural medicines provides ample evidence on the safety and efficacy of phytochemicals and nutraceuticals against diverse chronic ailments...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28189076/depression-social-support-and-long-term-risk-for-coronary-heart-disease-in-a-13-year-longitudinal-epidemiological-study
#13
Richard T Liu, Evelyn M Hernandez, Zoë M Trout, Evan M Kleiman, Melanie L Bozzay
Depression has been linked with long-term risk for a variety of physical health ailments, including coronary heart disease (CHD). Little is known about resilience factors that may attenuate this relationship. The current study assessed whether social support moderates the long-term risk for CHD associated with this disorder. Data were drawn from the Americans' Changing Lives study, a nationally representative longitudinal survey of adults in the United States. Participants (unweighted n=1636) completed initial assessments of functional social support, body mass index, recent history of major depression, CHD, hypertension, and diabetes...
February 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28182096/veronicastrum-axillare-alleviates-ethanol-induced-injury-on-gastric-epithelial-cells-via-downregulation-of-the-nf-kb-signaling-pathway
#14
Wei-Chun Zhao, Yan-Shan Xu, Gang Chen, Yan Guo, Dan-Yi Wang, Gui-Bin Meng
We used human gastric epithelial cells (GES-1) line in an ethanol-induced cell damage model to study the protective effect of Veronicastrum axillare and its modulation to NF-κB signal pathway. The goal was to probe the molecular mechanism of V. axillare decoction in the prevention of gastric ulcer and therefore provide guidance in the clinical application of V. axillare on treating injuries from chronic nephritis, pleural effusion, gastric ulcer, and other ailments. The effects of V. axillare-loaded serums on cell viability were detected by MTT assays...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28182027/critical-review-of-rasaratna-samuccaya-a-comprehensive-treatise-of-indian-alchemy
#15
REVIEW
Dhirajsingh Sumersingh Rajput, Rohit Gokarn, Chandrashekhar Y Jagtap, R Galib, B J Patgiri, P K Prajapati
Rasaratna Samuccaya (RRS) a 13(th) century C.E. alchemical treatise, authored by Vāgbhaṭa, is a useful compilation related to preparation and properties of drugs of mineral and metallic origin. This text throws light on the state of Indian expertise in the field of alchemy regarding the extraction, purification, conversion of metals/minerals into therapeutically suitable forms, various instruments developed for alchemical purposes and treatment of numerous diseases by using herbo-mineral preparations. The present work is an attempt to summarize the key features of RRS to highlight its utility and contribution in the development of Indian alchemy...
July 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28178024/the-effects-of-curcuminoids-on-musculoskeletal-pain-a-systematic-review
#16
Andrew Gaffey, Helen Slater, Kylie Porritt, Jared M Campbell
BACKGROUND: Western countries are increasingly using complementary and alternative medicine (CAM) to assist with relieving ailments. Turmeric, from the ginger family Zingiberaceae, has a history of use for medicinal purposes. The polyphenols found in turmeric (curcuminoids) have demonstrated anti-inflammatory and pain relieving properties. With the use of CAMs increasing, it is important for the effectiveness of curcuminoids to be established. OBJECTIVES: To identify the effectiveness of the use of curcuminoids for the amelioration of musculoskeletal pain...
February 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28173766/factors-influencing-decision-of-general-practitioners-and-managers-to-train-and-employ-a-nurse-practitioner-or-physician-assistant-in-primary-care-a-qualitative-study
#17
Mieke van der Biezen, Emmy Derckx, Michel Wensing, Miranda Laurant
BACKGROUND: Due to the increasing demand on primary care, it is not only debated whether there are enough general practitioners (GPs) to comply with these demands but also whether specific tasks can be performed by other care providers. Although changing the workforce skill mix care by employing Physician Assistants (PAs) and Nurse Practitioners (NPs) has proven to be both effective and safe, the implementation of those professionals differs widely between and within countries. To support policy making regarding PAs/NPs in primary care, the aim of this study is to provide insight into factors influencing the decision of GPs and managers to train and employ a PA/NP within their organisation...
February 7, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28169948/mitochondrial-dna-mutations-and-cardiovascular-disease
#18
Alexander W Bray, Scott W Ballinger
PURPOSE OF REVIEW: Cardiovascular disease (CVD) is responsible for more morbidity and mortality worldwide than any other ailment. Strategies for reducing CVD prevalence must involve identification of individuals at high risk for these diseases, and the prevention of its initial development. Such preventive efforts are currently limited by an incomplete understanding of the genetic determinants of CVD risk. In this review, evidence for the involvement of inherited mitochondrial mutations in development of CVD is examined...
February 4, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28168953/stroke-disclosing-primary-aldosteronism-report-on-three-cases-and-review-of-the-literature
#19
Amina Nasri, Malek Mansour, Zeineb Brahem, Amel Kacem, Ahmed Abou Hassan, Hager Derbali, Meriem Messelmani, Jamel Zaouali, Ridha Mrissa
OBJECTIVES: There is a growing evidence of increased risk of cerebrovascular events in primary aldosteronism (PA). Nevertheless, acute neurologic ailment as presenting feature of PA is uncommon. Our aim is to highlight the diagnosis challenges in stroke unmasking PA and to discuss the underlying physiopathology and management dilemmas. MATERIALS AND METHODS: We hereby describe three consecutive rare cases of stroke revealing PA. All patients had brain imaging and thorough biological and morphological assessment to rule out other etiologies of stroke...
February 3, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28167471/effect-of-viscum-schimperi-on-advanced-glycation-endproducts-formation
#20
Hossam Mohamed Abdallah, Doha Omar ALGhamdi, Maab Siddiq Al-Salem, Maryam Alattas, Hany Mohamed El-Bassossy, Abdulrahman Mohammed Alahdal, Ibrahim Ateya Shehata, Essam Abdel-Sattar
Diabetes is a disease characterized by elevated uncontrolled glucose level. Hyperglycemia results in diabetic complication due to a reaction between sugar and amino acid of proteins to form advanced glycation endproducts (AGEs) in different tissues. Medicinal plants are considered as a great source of bioactive compounds that affect many ailments. In this regard; AGEs formation could be inhibited by many bioactive compounds isolated from medicinal plants. Viscum schimperi Engl. is a plant belongs to Loranthaceae and known for its antidiabetic activity...
November 2016: Pakistan Journal of Pharmaceutical Sciences
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