Ying Wang, Diane Heels-Ansdell, Long Ge, Sameer Parpia, Quazi Ibrahim, Deborah Cook, Adam Deane, Francois Lauzier, Naomi Hammond, Morten H Møller, Mette Krag, Anders Perner, Gordon H Guyatt
BACKGROUND: Proton pump inhibitors (PPIs) are the most commonly prescribed drugs for preventing upper gastrointestinal bleeding in critically ill patients. However, concerns have arisen about the possible harms of using PPIs, including potentially increased risk of pneumonia, Clostridioides difficile infection, and more seriously, an increased risk of death in the most severely ill patients. Triggered by the REVISE trial, which is a forthcoming large randomized trial comparing pantoprazole to placebo in invasively mechanically ventilated patients, we will conduct this systematic review to evaluate the efficacy and safety of PPIs versus no prophylaxis for critically ill patients...
April 5, 2024: Acta Anaesthesiologica Scandinavica