Jamie L Grit, Lauren E McGee, Elizabeth A Tovar, Curt J Essenburg, Emily Wolfrum, Ian Beddows, Kaitlin Williams, Rachael T C Sheridan, Joshua L Schipper, Marie Adams, Menusha Arumugam, Thomas Vander Woude, Sharavana Gurunathan, Jeffrey M Field, Julia Wulfkuhle, Emanuel F Petricoin, Carrie R Graveel, Matthew R Steensma
Malignant peripheral nerve sheath tumors (MPNSTs) are chemotherapy resistant sarcomas that are a leading cause of death in neurofibromatosis type 1 (NF1). Although NF1-related MPNSTs derive from neural crest cell origin, they also exhibit intratumoral heterogeneity. TP53 mutations are associated with significantly decreased survival in MPNSTs, however the mechanisms underlying TP53-mediated therapy responses are unclear in the context of NF1-deficiency. We evaluated the role of two commonly altered genes, MET and TP53, in kinome reprograming and cellular differentiation in preclinical MPNST mouse models...
March 13, 2024: Oncogene