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https://www.readbyqxmd.com/read/28427886/identification-of-excipients-for-stabilizing-fiberless-adenovirus-as-biopharmaceuticals
#1
Grit Kupgan, Shyamal P Choudhari, Nicholas H Flynn, Adane Nigatu, Sravanthi Vupputuri, William D Picking, Wendy L Picking, Joshua D Ramsey
Reducing the promiscuous tropism of native adenovirus by using fiberless adenovirus is advantageous towards its use as a gene therapy vector or vaccine component. The removal of the fiber protein on native adenovirus abrogates several undesirable interactions; however, this approach decreases the particle's physical stability. In order to create stable fiberless adenovirus for pharmaceutical use, the effects of temperature and pH on the particle's stability profile must be addressed. Our results indicate that the stability of fiberless adenovirus is increased when it is stored in mildly acidic conditions around pH 6...
April 17, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28426200/facile-design-and-fabrication-of-superwetting-surfaces-with-excellent-wear-resistance
#2
Wenbo Zhang, Tianhao Xiang, Feng Liu, Ming Zhang, Wentao Gan, Xianglin Zhai, Xin Di, Yazhou Wang, Guoxiang Liu, Chengyu Wang
Preparation of mechanically durable superwetting surfaces is imperative, yet challenging for the wide range of real applications where high durability is required. Mechanical wear on superwetting surfaces usually degrades weak roughness, leading to loss of functions. In this study, wear-resistant superhydrophilic/underwater superoleophobic and superhydrophobic surfaces are prepared by anchoring reinforced coatings via adhesive-swelling and adhesive-bonding processes, respectively. The results of the sandpaper abrasion (grit no...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28423755/why-are-children-s-interests-invisible-in-european-national-e-health-strategies
#3
Michael J Rigby, Grit Kühne, Azeem Majeed, Mitch E Blair
Harnessing the power of IT solutions in child primary care requires strategic thought at national level, and good health care delivery needs this support. The aim of this study was to investigate whether children's needs are considered in national e-health strategies in Europe. In 2016, a survey was carried out in all 28 European Member States plus 2 European Economic Area countries. Sixteen countries fail to mention children's needs at all. Only eleven of 27 countries mention children and adolescents in their national e-health strategy documents ranging from mere data protection concerns to comprehensive IT approaches for the improvement of child primary care...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423754/towards-safe-and-efficient-child-primary-care-gaps-in-the-use-of-unique-identifiers-in-europe
#4
Grit Kühne, Michael J Rigby, Azeem Majeed, Mitch E Blair
In order to provide for best possible child health care, timely access to all relevant medical data is of vital importance. The aim of this study is to investigate the use of unique identifiers, a key instrument in this regard, in the countries of Europe. A survey was carried out in all 28 European Member States plus 2 European Economic Area countries in 2015, and refreshed in 2016. In 23 countries unique identifiers are used to link children's health records. Five countries indicated they currently do not link child health records, and two have no such plans...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28416857/compositional-variability-of-nutrients-and-phytochemicals-in-corn-after-processing
#5
P S Prasanthi, N Naveena, M Vishnuvardhana Rao, K Bhaskarachary
The result of various process strategies on the nutrient and phytochemical composition of corn samples were studied. Fresh and cooked baby corn, sweet corn, dent corn and industrially processed and cooked popcorn, corn grits, corn flour and corn flakes were analysed for the determination of proximate, minerals, xanthophylls and phenolic acids content. This study revealed that the proximate composition of popcorn is high compared to the other corn products analyzed while the mineral composition of these maize products showed higher concentration of magnesium, phosphorus, potassium and low concentration of calcium, manganese, zinc, iron, copper, and sodium...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28414271/monitoring-atp-dynamics-in-electrically-active-white-matter-tracts
#6
Andrea Trevisiol, Aiman S Saab, Ulrike Winkler, Grit Marx, Hiromi Imamura, Wiebke Möbius, Kathrin Kusch, Klaus-Armin Nave, Johannes Hirrlinger
In several neurodegenerative diseases and myelin disorders, the degeneration profiles of myelinated axons are compatible with underlying energy deficits. However, it is presently impossible to measure selectively axonal ATP levels in the electrically active nervous system. We combined transgenic expression of an ATP-sensor in neurons of mice with confocal FRET imaging and electrophysiological recordings of acutely isolated optic nerves. This allowed us to monitor dynamic changes and activity-dependent axonal ATP homeostasis at the cellular level and in real time...
April 17, 2017: ELife
https://www.readbyqxmd.com/read/28414171/the-effects-of-water-on-degradation-of-the-zirconia-resin-bond
#7
C Chen, Y Chen, Z Lu, M Qian, H Xie, F R Tay
OBJECTIVES: 10-methacryloyloxydecyldihydrogenphosphate (MDP) containing primers improve bonding of yttria-stabilised tetragonal zirconia (Y-TZP) to methacrylate resins. The present study investigated the role played by water in the deterioration of MDP-mediated zirconia-resin bonds. METHODS: Grit-blasted Y-TZP plates were conditioned with two MDP primers and bonded with resin for shear bond strength (SBS) testing. Additional bonded plates were aged hydrothermally and compared with unaged Y-TZP after 24hours of water-storage or 6 months of water/acid/alkali-storage...
April 13, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28413590/effect-of-nano-hydroxyapatite-toothpaste-on-microhardness-ofartificial-carious-lesions-created-on-extracted-teeth
#8
Asghar Ebadifar, Mohammad Nomani, Sayed Ali Fatemi
Background. Many types of toothpastes contain substances that can remineralize initial enamel caries. This study aimed to assess the effect of nano-hydroxyapatite (NHA) on microhardness of artificially created carious lesions. Methods. In this in vitro study, NHA was prepared using sol-gel technique and added to the toothpaste with 7% concentration. A total of 80 extracted sound teeth were collected. The crowns were polished using 500-grit abrasive paper. The specimens were randomly coded from 1 to 80. Number 1 to 40 were assigned to group A and numbers 41 to 80 to group B...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28406881/early-healing-evaluation-of-commercially-pure-titanium-and-ti-6al-4v-presenting-similar-surface-texture-an-in-vivo-study
#9
Arthur Castellano, Luiz F Gil, Estevam A Bonfante, Nick Tovar, Rodrigo Neiva, Malvin N Janal, Paulo G Coelho
OBJECTIVE: This study evaluated the osseointegration of commercially pure titanium (Ti) grade-2 (G2) and Ti-6Al-4V alloy (G5) implants with the same geometry and surface treatment. MATERIALS AND METHODS: Thirty-six dental implants with a grit-blasted acid-etched surface were used (n = 18, each). Two implants, one per group, were installed in each subject, in the radius diaphysis (n = 18 beagle dogs), with interchanged fixture position (proximal-distal) between animals for a balanced number of devices per group and time in vivo (1, 3, and 6 weeks)...
April 12, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28403660/value-based-choice-an-integrative-neuroscience-informed-model-of-health-goals
#10
Elliot T Berkman
OBJECTIVE: Traditional models of health behaviour focus on the roles of cognitive, personality and social-cognitive constructs (e.g. executive function, grit, self-efficacy), and give less attention to the process by which these constructs interact in the moment that a health-relevant choice is made. Health psychology needs a process-focused account of how various factors are integrated to produce the decisions that determine health behaviour. DESIGN: I present an integrative value-based choice model of health behaviour, which characterises the mechanism by which a variety of factors come together to determine behaviour...
April 13, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28401642/misfit-of-organizational-and-personal-work-standards-and-its-longitudinal-effect-on-physicians-depressiveness
#11
Grit Tanner, Eva Bamberg, Maren Kersten, Agnessa Kozak, Albert Nienhaus
The misfit of organizational and personal work standards and its relationship to health is an issue that has rarely been investigated in hospital physicians. In particular, compensatory factors for the negative effects of a misfit of organizational and personal work standards remain unknown. Our longitudinal study investigated whether autonomous experiences at work and during leisure time compensate for the effects of a misfit of organizational and personal work standards on depressive complaints. Data were collected through surveys of German hospital physicians...
April 12, 2017: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/28398538/the-role-of-grit-in-college-student-health-care-management-skills-and-health-related-quality-of-life
#12
Christina M Sharkey, Dana M Bakula, Kaitlyn L Gamwell, Alexandria J Mullins, John M Chaney, Larry L Mullins
To examine the relationship of grit, an intrapersonal characteristic defined by perseverance and passion for long-term goals, to health care management skills and adolescent and young adult (AYA) health-related quality of life (HRQoL). Higher levels of grit were expected to relate to greater health care management skills and HRQoL, and skills were predicted to mediate the relationship between grit and HRQoL. Four hundred seventy undergraduates ( Mdn age =19, interquartile range = 2) completed online questionnaires, including the short Grit Scale, Transition Readiness Assessment Questionnaire, and 36-Item Short Form Survey (SF-36) (HRQoL)...
April 8, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28390452/changes-of-surface-properties-of-composite-preveneered-stainless-steel-crowns-after-prophy-polishing-to-remove-stains
#13
Khanh Truong, Jung-Wei Chen, Sean Lee, Holli Riter
PURPOSE: The purpose of this study was to assess the effect of fine-, medium-, and coarse-grit prophy paste used to polish grape juice-stained preveneered stainless steel crowns (PvSSCs). METHODS: Forty-five maxillary central incisor PvSSCs were immersed in grape juice for 30 days and randomly assigned to three groups (<small>n</small> equals 15) using fine-, medium-, and coarse-grit prophy paste for polishing. Color measurement (L*a*b*), surface roughness (Ra), and scanning electron microscopy imaging were performed at prestain, poststain, and postpolish periods...
March 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/28387316/lkb1-inactivation-drives-lung-cancer-lineage-switching-governed-by-polycomb-repressive-complex-2
#14
Haikuo Zhang, Christine Fillmore Brainson, Shohei Koyama, Amanda J Redig, Ting Chen, Shuai Li, Manav Gupta, Carolina Garcia-de-Alba, Margherita Paschini, Grit S Herter-Sprie, Gang Lu, Xin Zhang, Bryan P Marsh, Stephanie J Tuminello, Chunxiao Xu, Zhao Chen, Xiaoen Wang, Esra A Akbay, Mei Zheng, Sangeetha Palakurthi, Lynette M Sholl, Anil K Rustgi, David J Kwiatkowski, J Alan Diehl, Adam J Bass, Norman E Sharpless, Glenn Dranoff, Peter S Hammerman, Hongbin Ji, Nabeel Bardeesy, Dieter Saur, Hideo Watanabe, Carla F Kim, Kwok-Kin Wong
Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autochthonous and transplant models. Chromatin analysis reveals loss of H3K27me3 and gain of H3K27ac and H3K4me3 at squamous lineage genes, including Sox2, ΔNp63 and Ngfr. SCC lesions have higher levels of the H3K27 methyltransferase EZH2 than the ADC lesions, but there is a clear lack of the essential Polycomb Repressive Complex 2 (PRC2) subunit EED in the SCC lesions...
April 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28374419/the-acute-phase-mediator-serum-amyloid-a-is-associated-with-symptoms-of-depression-and-fatigue
#15
E Y Bryleva, S A Keaton, J Grit, Z Madaj, A Sauro-Nagendra, L Smart, S Halstead, E Achtyes, L Brundin
OBJECTIVE: Establish whether inflammatory biomarkers-serum amyloid A (SAA), C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)-are related to key symptoms of depression, including anxiety and fatigue, in a cross-sectional, out-patient setting to identify biomarkers that reflect psychiatric symptomatology in a naturalistic, real-life population. METHODS: We measured SAA, CRP, IL-6, and TNF-α in plasma samples from 89 adult psychiatric out-patients by multiplex, high-sensitivity electrochemiluminescent assays...
May 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28372225/carotenoid-and-color-changes-in-traditionally-flaked-and-extruded-products
#16
Mario Cueto, Abel Farroni, Regine Schoenlechner, Gerhard Schleining, Pilar Buera
The objective of this study was to evaluate the impact of process and formulation on individual carotenoid loss in traditionally prepared cornflakes and those prepared by extrusion. The first step in the traditional process (maize grits cooking) promoted a 60% lutein content reduction and 40% in zeaxanthin loss, showing lutein more susceptibility to isomerization and decomposition. After toasting, the last step, the total loss averaged 80% for both compounds. The extruded maize in a plain formulation showed a 35% lutein and zeaxanthin reduction...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28369955/effect-of-extrusion-on-physicochemical-properties-digestibility-and-phenolic-profiles-of-grit-fractions-obtained-from-dry-milling-of-normal-and-waxy-corn
#17
Sheetal Thakur, Narpinder Singh, Amritpal Kaur, Baljit Singh
Extrusion behavior of grits obtained from 3 successive reductions of dry milling of 2 normal corn types and 1 waxy corn was studied at different extrusion temperatures (ET). The grit from each reduction stage (RS) showed the presence of base-hydrolyzed bound protocatechuic acid, p-coumaric acid, sinapic acid, ferulic acid, and quercetin, and the concentrations of these decreased after acid hydrolysis and that of gallic acid increased. African tall grit from all RSs showed the highest average specific mechanical energy (SME) and torque, while waxy corn grit had the lowest...
March 29, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28366784/enhanced-osteogenic-differentiation-of-rat-bone-marrow-mesenchymal-stem-cells-on-titanium-substrates-by-inhibiting-notch3
#18
Huiming Wang, Zhiwei Jiang, Jing Zhang, Zhijian Xie, Ying Wang, Guoli Yang
OBJECTIVE: The role of the Notch pathway has already been identified as a crucial regulator of bone development. However, the Notch signaling pathway has gone largely unexplored during osseointegration. This study aims to investigate the role of Notch signaling on osteogenic differentiation of rat derived bone marrow mesenchymal stem cells (BMSCs) on sandblasted, large-grit, acid-etched (SLA) treated Ti disks. METHODS: The involved target genes in Notch pathways were identified by in vitro microarray and bioinformatics analyses with or without osteogenic induction...
March 19, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28364899/atomic-force-microscopy-analysis-of-enamel-nanotopography-after-interproximal-reduction
#19
Lydia Meredith, Mauro Farella, Sam Lowrey, Richard D Cannon, Li Mei
INTRODUCTION: Interproximal reduction (IPR) removes enamel and leaves grooves and furrows on the tooth surface, which may increase the risk of caries. The aims of this study were to assess the nanotopography of enamel surfaces produced by the most commonly used IPR instruments and to evaluate the effect of polishing after IPR. METHODS: Enamel slabs were cut from the interproximal surfaces of healthy premolars and then treated with diamond burs, strips, or discs, or Sof-Lex polishing discs (3M ESPE, St Paul, Minn)...
April 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28357137/diet-induced-obesity-is-associated-with-an-impaired-nk-cell-function-and-an-increased-colon-cancer-incidence
#20
Ina Bähr, Vincent Goritz, Henriette Doberstein, Grit Gesine Ruth Hiller, Philip Rosenstock, Janine Jahn, Ole Pörtner, Tobias Berreis, Thomas Mueller, Julia Spielmann, Heike Kielstein
Obesity is associated with an increased colon cancer incidence, but underlying mechanisms remained unclear. Previous studies showed altered Natural killer (NK) cell functions in obese individuals. Therefore, we studied the impact of an impaired NK cell functionality on the increased colon cancer risk in obesity. In vitro investigations demonstrated a decreased IFN-γ secretion and cytotoxicity of human NK cells against colon tumor cells after NK cell preincubation with the adipokine leptin. In addition, leptin incubation decreased the expression of activating NK cell receptors...
2017: Journal of Nutrition and Metabolism
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