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https://www.readbyqxmd.com/read/27914413/differences-in-acoustic-impedance-of-fresh-and-embedded-human-trabecular-bone-samples-scanning-acoustic-microscopy-and-numerical-evaluation
#1
Xiaowei Ojanen, Juha Töyräs, Satu I Inkinen, Markus K H Malo, Hanna Isaksson, Jukka S Jurvelin
Trabecular bone samples are traditionally embedded and polished for scanning acoustic microscopy (SAM). The effect of sample processing, including dehydration, on the acoustic impedance of bone is unknown. In this study, acoustic impedance of human trabecular bone samples (n = 8) was experimentally assessed before (fresh) and after embedding using SAM and two-dimensional (2-D) finite-difference time domain simulations. Fresh samples were polished with sandpapers of different grit (P1000, P2500, and P4000)...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27911799/mechanism-of-the-intrinsic-arginine-finger-in-heterotrimeric-g-proteins
#2
Daniel Mann, Christian Teuber, Stefan A Tennigkeit, Grit Schröter, Klaus Gerwert, Carsten Kötting
Heterotrimeric G proteins are crucial molecular switches that maintain a large number of physiological processes in cells. The signal is encoded into surface alterations of the Gα subunit that carries GTP in its active state and GDP in its inactive state. The ability of the Gα subunit to hydrolyze GTP is essential for signal termination. Regulator of G protein signaling (RGS) proteins accelerates this process. A key player in this catalyzed reaction is an arginine residue, Arg178 in Gαi1, which is already an intrinsic part of the catalytic center in Gα in contrast to small GTPases, at which the corresponding GTPase-activating protein (GAP) provides the arginine "finger...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27893886/integrin-%C3%AE-5%C3%AE-1-inhibition-by-clt-28643-reduces-postoperative-wound-healing-in-a-mouse-model-of-glaucoma-filtration-surgery
#3
Tine Van Bergen, Grit Zahn, Patrizia Caldirola, Mario Fsadni, Ninus Caram-Lelham, Evelien Vandewalle, Lieve Moons, Ingeborg Stalmans
Purpose: To evaluate the therapeutic potential of the small molecule integrin α5β1 inhibitor, CLT-28643, to improve the filtering surgery outcome in a mouse model. Different dose regimens and administration routes of the inhibitor were compared with mitomycin C (MMC), the gold standard in clin ical practice. Methods: The efficacy of CLT-28643 on surgical outcome was studied in a mouse model for filtering surgery (n = 40 eyes from 20 mice per group). Single and repeated subconjunctival (SCJ) injections (1 or 2 μg) and topical eye drops (10 μg) of the integrin inhibitor were compared with 2-minute administration of MMC 0...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27887831/long-term-cu-stabilization-and-biomass-yields-of-giant-reed-and-poplar-after-adding-a-biochar-alone-or-with-iron-grit-into-a-contaminated-soil-from-a-wood-preservation-site
#4
Nadège Oustriere, Lilian Marchand, Nathalie Lottier, Mikael Motelica, Michel Mench
A 2-year pot experiment was carried out to examine the aging effect of biochar (B), alone or combined with iron grit (Z), on Cu stabilization and plant growth in a contaminated soil (964mg Cu kg(-1)) from a wood preservation site. The experiment consisted in 3 soil treatments, either planted with Arundo donax L. (Ad) or Populus nigra L. (Pn): (1) untreated Cu-contaminated soil (Ad, Pn); (2) Unt+1% (w/w) B (AdB, PnB), and (3) Unt+1% B+1% Z (AdBZ, PnBZ). After 22months, the soil pore water (SPW) was sampled and roots and shoots were harvested...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27885966/er-cr-ysgg-laser-effectively-ablates-single-species-biofilms-on-titanium-disks-without-detectable-surface-damage
#5
Jason M Strever, Jaebum Lee, William Ealick, Mark Peacock, Daniel Shelby, Cristiano Susin, Donald Mettenberg, Ahmed El-Awady, Frederick Rueggeberg, Christopher W Cutler
BACKGROUND: Increasing evidence implicates biofilms, consisting of species such as Porphyromonas gingivalis, in the etiology of peri-implantitis. Multiple approaches to ablate biofilms on failing implants have been proposed, include the use of lasers; most recently the Er,Cr:YSGG laser. The purpose of this study is to establish an in-vitro single-species biofilm model on implant surfaces and determine power settings of the Er,Cr:YSGG laser that remove the biofilm while not causing physical damage to the disk...
November 25, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27884778/expression-of-adipokines-in-osteoarthritis-osteophytes-and-their-effect-on-osteoblasts
#6
Susann Junker, Klaus W Frommer, Grit Krumbholz, Lali Tsiklauri, Rüdiger Gerstberger, Stefan Rehart, Jürgen Steinmeyer, Markus Rickert, Sabine Wenisch, Georg Schett, Ulf Müller-Ladner, Elena Neumann
OBJECTIVE: Osteophyte formation in osteoarthritis (OA) is mediated by increased osteoblast activity, which is -in turn- regulated by the Wnt signaling pathway. Obesity is regarded a risk factor in OA, yet little is known about the interaction between adipose tissue-derived factors, the adipokines, and bone formation, although adipokines are associated with the pathogenesis of OA. Therefore, the effect of adipokines on bone and cartilage forming cells and osteophyte development was analyzed...
November 21, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27882311/retrospective-clinical-study-of-an-implant-with-a-sandblasted-large-grit-acid-etched-surface-and-internal-connection-analysis-of-short-term-success-rate-and-marginal-bone-loss
#7
Jae-Wang Lee, Jun Hyeong An, Sang-Hoon Park, Jong-Hyon Chong, Gwang-Seok Kim, JeongJoon Han, Seunggon Jung, Min-Suk Kook, Hee-Kyun Oh, Sun-Youl Ryu, Hong-Ju Park
BACKGROUND: The purpose of this retrospective study was to evaluate the clinical utility of an implant with a sandblasted, large-grit, acid-etched (SLA) surface and internal connection. METHODS: Six patients who received dental implants in the Department of Oral and Maxillofacial Surgery, Chonnam National University Dental Hospital, were analyzed by factors influencing the success rate and marginal bone loss. Factors included patient's age, sex, implant installation site, whether bone graft was done, type of bone graft materials, approaching method if sinus lift was done, and the size of the fixture...
December 2016: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27881639/enhancement-of-osseointegration-by-direct-coating-of-rhbmp-2-on-target-ion-induced-plasma-sputtering-treated-sla-surface-for-dental-application
#8
Sungwon Kim, Cheonil Park, Byeong-Seok Moon, Hyoun-Ee Kim, Tae-Sik Jang
Owing to the excellent bioactive properties of recombinant human bone morphogenetic proteins (rhBMPs), dentistry considers them as a fascinating adjuvant alternative for enhancing bone regeneration and bone-to-implant junction in the early implantation stages. However, stable loading and delivery efficiency of rhBMPs on the implant surfaces involve major concerns because of the harsh wearing condition under load during implantation. In this study, to achieve successful rhBMP-2 delivery, a nanoporous surface structure is introduced on the sandblasting with large grit and acid-etching (SLA)-treated titanium (Ti) surface via the tantalum (Ta) target-ion induced plasma sputtering (TIPS) technique...
November 23, 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27864350/grit-and-burnout-in-uk-doctors-a-cross-sectional-study-across-specialties-and-stages-of-training
#9
Laura Halliday, Abigail Walker, Stella Vig, John Hines, John Brecknell
PURPOSE OF THE STUDY: Grit is characterised by the ability to persevere during difficulties and maintain a sustained effort over an extended period of time. Throughout their careers, doctors will experience many periods of stress and difficulty. This may result in burnout, defined by the presence of exhaustion and disengagement from work. This study aims to characterise the relationship between grit and burnout in doctors and to establish whether there are differences between specialties and levels of training...
November 18, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27862998/sex-ratio-of-mirid-populations-shifts-in-response-to-hostplant-co-infestation-or-altered-cytokinin-signaling
#10
Nora Adam, Theresa Erler, Mario Kallenbach, Martin Kaltenpoth, Grit Kunert, Ian T Baldwin, Meredith C Schuman
Herbivore species sharing a host plant often compete. In this study, we show that host plant-mediated interaction between two insect herbivores - a generalist and a specialist - results in a sex ratio shift of the specialist's offspring. We studied demographic parameters of the specialist Tupiocoris notatus (Hemiptera: Miridae) when co-infesting the host plant Nicotiana attenuata (Solanaceae) with the generalist leafhopper Empoasca sp. (Hemiptera: Cicadellidae). We show that the usually female-biased sex ratio of T...
November 14, 2016: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/27856426/cytotoxic-t-cells-in-pd-l1-positive-malignant-pleural-mesotheliomas-are-counterbalanced-by-distinct-immunosuppressive-factors
#11
Mark M Awad, Robert E Jones, Hongye Liu, Patrick H Lizotte, Elena V Ivanova, Meghana Kulkarni, Grit S Herter-Sprie, Xiaoyun Liao, Abigail A Santos, Mark A Bittinger, Lauren Keogh, Shohei Koyama, Christina Almonte, Jessie M English, Julianne Barlow, William G Richards, David A Barbie, Adam J Bass, Scott J Rodig, F Stephen Hodi, Kai W Wucherpfennig, Pasi A Jänne, Lynette M Sholl, Peter S Hammerman, Kwok-Kin Wong, Raphael Bueno
PD-L1 immunohistochemical staining does not always predict whether a cancer will respond to treatment with PD-1 inhibitors. We sought to characterize immune cell infiltrates and the expression of T-cell inhibitor markers in PD-L1-positive and PD-L1-negative malignant pleural mesothelioma samples. We developed a method for immune cell phenotyping using flow cytometry on solid tumors that have been dissociated into single-cell suspensions and applied this technique to analyze 43 resected malignant pleural mesothelioma specimens...
December 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27855994/flexural-resistance-of-heat-pressed-and-cad-cam-lithium-disilicate-with-different-translucencies
#12
Riccardo Fabian Fonzar, Michele Carrabba, Maurizio Sedda, Marco Ferrari, Cecilia Goracci, Alessandro Vichi
OBJECTIVE: To compare flexural strength of CAD-CAM and heat-pressed lithium disilicate. METHODS: For Pressed specimens (Group A), acrylate polymer blocks were cut with a saw in bars shape. Sprueing, investing and preheating procedures were carried out following manufacturer's instructions. IPS e.max Press ingots (Ivoclar-Vivadent) were divided into subgroups (n=15) according to translucency: A.1=HT-A3; A.2=MT-A3; A.3=LT-A3; A.4=MO2. Ingots were then pressed following manufacturer's instructions...
November 14, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27855923/impact-of-industrial-dry-milling-on-fumonisin-redistribution-in-non-transgenic-corn-in-brazil
#13
Jaqueline Gozzi Bordini, Mario Augusto Ono, Glauco Tironi Garcia, Victor Hugo Meconi Fazani, Édio Vizoni, Karem Caroline Bonacin Rodrigues, Elisa Yoko Hirooka, Elisabete Yurie Sataque Ono
The aim of this study was to evaluate the fate of fumonisins B1 (FB1) and B2 (FB2) during industrial dry-milling in two lots from 2014 (n=120) and 2015 (n=120) of non-transgenic corn and their fractions (germ, pericarp, endosperm, cornmeal and grits), collected from one of the major Brazilian milling industries. Fumonisins were concentrated in the germ and pericarp at a rate of 322% and 188% (lot 1) and 311% and 263% (lot 2), respectively. In the endosperm, cornmeal and grits fumonisin levels decreased from 60 to 95%...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27853347/surface-treatment-comparison-by-application-of-diamond-bur-and-er-cr-ysgg-at-different-powers-morphological-and-mechanical-evaluation
#14
Mansoreh Mirzaie, Esmael Yassini, Ardavan Etemadi, Atefeh Tavakoli, Nasim Chiniforush
Purpose: This study evaluated the micro-tensile bond strength of new and previous composite resin restorations after surface treatment with diamond bur and Er,Cr:YSGG laser at different power settings (2,3 and 4 W). Materials and methods: Micro-hybride composite resin was inserted in metallic mold 5 ×5 ×15 mm and cured for 40 sec according to manufacturer's instruction.12 blocks were made. The bonded surfaces of the 12 blocks so obtained were subsequently ground using Silicon Carbide papers 1200 grit, for 15 seconds under running water...
October 1, 2016: Laser Therapy
https://www.readbyqxmd.com/read/27849140/pflegekr%C3%A3-fte-aus-vietnam
#15
Verena Peters, Grit Braeseke
No abstract text is available yet for this article.
November 2016: Pflege
https://www.readbyqxmd.com/read/27846904/an-ex-vivo-human-cartilage-repair-model-to-evaluate-the-potency-of-a-cartilage-cell-transplant
#16
Christoph Bartz, Miriam Meixner, Petra Giesemann, Giulietta Roël, Grit-Carsta Bulwin, Jeske J Smink
BACKGROUND: Cell-based therapies such as autologous chondrocyte implantation are promising therapeutic approaches to treat cartilage defects to prevent further cartilage degeneration. To assure consistent quality of cell-based therapeutics, it is important to be able to predict the biological activity of such products. This requires the development of a potency assay, which assesses a characteristic of the cell transplant before implantation that can predict its cartilage regeneration capacity after implantation...
November 15, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27845531/much-ado-about-grit-a-meta-analytic-synthesis-of-the-grit-literature
#17
Marcus Credé, Michael C Tynan, Peter D Harms
Grit has been presented as a higher order personality trait that is highly predictive of both success and performance and distinct from other traits such as conscientiousness. This paper provides a meta-analytic review of the grit literature with a particular focus on the structure of grit and the relation between grit and performance, retention, conscientiousness, cognitive ability, and demographic variables. Our results based on 584 effect sizes from 88 independent samples representing 66,807 individuals indicate that the higher order structure of grit is not confirmed, that grit is only moderately correlated with performance and retention, and that grit is very strongly correlated with conscientiousness...
June 16, 2016: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/27832734/constructing-and-deconstructing-concepts
#18
Charles A Doan, Ronaldo Vigo
Several empirical investigations have explored whether observers prefer to sort sets of multidimensional stimuli into groups by employing one-dimensional or family-resemblance strategies. Although one-dimensional sorting strategies have been the prevalent finding for these unsupervised classification paradigms, several researchers have provided evidence that the choice of strategy may depend on the particular demands of the task. To account for this disparity, we propose that observers extract relational patterns from stimulus sets that facilitate the development of optimal classification strategies for relegating category membership...
September 2016: Experimental Psychology
https://www.readbyqxmd.com/read/27832091/impedance-flow-cytometry-a-novel-technique-in-pollen-analysis
#19
Iris Heidmann, Grit Schade-Kampmann, Joep Lambalk, Marcel Ottiger, Marco Di Berardino
INTRODUCTION: An efficient and reliable method to estimate plant cell viability, especially of pollen, is important for plant breeding research and plant production processes. Pollen quality is determined by classical methods, like staining techniques or in vitro pollen germination, each having disadvantages with respect to reliability, analysis speed, and species dependency. Analysing single cells based on their dielectric properties by impedance flow cytometry (IFC) has developed into a common method for cellular characterisation in microbiology and medicine during the last decade...
2016: PloS One
https://www.readbyqxmd.com/read/27817828/in%C3%A2-vitro-assessment-of-cutting-efficiency-and-durability-of-zirconia-removal-diamond-rotary-instruments
#20
Joon-Soo Kim, Ji-Hyeon Bae, Mi-Jung Yun, Jung-Bo Huh
STATEMENT OF PROBLEM: Recently, zirconia removal diamond rotary instruments have become commercially available for efficient cutting of zirconia. However, research of cutting efficiency and the cutting characteristics of zirconia removal diamond rotary instruments is limited. PURPOSE: The purpose of this in vitro study was to assess and compare the cutting efficiency, durability, and diamond rotary instrument wear pattern of zirconia diamond removal rotary instruments with those of conventional diamond rotary instruments...
November 3, 2016: Journal of Prosthetic Dentistry
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