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https://www.readbyqxmd.com/read/29679702/alamandine-attenuates-sepsis-associated-cardiac-dysfunction-via-inhibiting-mapks-signaling-pathways
#1
Peng Li, Xi-Ru Chen, Fei Xu, Chi Liu, Chang Li, Hui Liu, Hui Wang, Wei Sun, Yan-Hui Sheng, Xiang-Qing Kong
Sepsis-induced myocardial dysfunction represents a major cause of death in intensive care units. Alamandine is an important biologically active peptide in the renin-angiotensin system. The present study evaluated whether alamandine improves cardiac dysfunction, inflammation, and apoptosis, and affects the signaling pathways involved in these events. Experiments were carried out in mice treated with lipopolysaccharide (LPS) or alamandine, and in neonatal rat cardiomyocytes. Alamandine increased the ejection fraction and fractional shortening, both of which were decreased upon LPS infusion in mice...
April 18, 2018: Life Sciences
https://www.readbyqxmd.com/read/29651539/skeletal-muscle-stem-cell-characteristics-and-myonuclei-content-in-patients-with-rheumatoid-arthritis-a-cross-sectional-study
#2
Rasmus Jentoft Boutrup, Jean Farup, Kristian Vissing, Michael Kjaer, Ulla Ramer Mikkelsen
To investigate satellite cells (SCs) and myonuclei characteristics in patients with rheumatoid arthritis (RA). Resting biopsies from m. vastus lateralis were obtained from thirteen RA patients and thirteen matched healthy controls (CON). Muscle biopsies were immunohistochemically stained and analyzed for fiber type specific content of SCs (Pax7+ ), proliferating SCs (Pax7+ /MyoD+ ) and differentiating SCs (myogenin+ ). Furthermore, we quantified fiber type specific content of myonuclei and myofiber cross-sectional area (CSA)...
April 12, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29642375/molecular-characterization-of-gastric-epithelial-cells-using-flow-cytometry
#3
Kevin A Bockerstett, Chun Fung Wong, Sherri Koehm, Eric L Ford, Richard J DiPaolo
The ability to analyze individual epithelial cells in the gastric mucosa would provide important insight into gastric disease, including chronic gastritis and progression to gastric cancer. However, the successful isolation of viable gastric epithelial cells (parietal cells, neck cells, chief cells, and foveolar cells) from gastric glands has been limited due to difficulties in tissue processing. Furthermore, analysis and interpretation of gastric epithelial cell flow cytometry data has been difficult due to the varying sizes and light scatter properties of the different epithelial cells, high levels of autofluorescence, and poor cell viability...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29625473/corneal-epithelial-cells-exhibit-myeloid-characteristics-and-present-antigen-via-mhc-class-ii
#4
Derek J Royer, Michael H Elliott, Yun Z Le, Daniel J J Carr
Purpose: To explore the impact of ocular surface insults on the immunomodulatory capacity and phenotype of corneal epithelial cells (CECs) with a focus on epithelial-mesenchymal transition (EMT). Methods: Corneas were harvested from mice 6 days following scratch injury, ragweed pollen-induced allergy, or herpes simplex virus type 1 (HSV-1) infection and compared to healthy tissue controls. Corneas were enzymatically digested and CECs phenotypically characterized using flow cytometry...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29601965/high-yield-production-of-human-invariant-chain-cd74-constructs-fused-to-solubility-enhancing-peptides-and-characterization-of-their-mif-binding-capacities
#5
Tjie Kok, Anna A Wasiel, Frank J Dekker, Gerrit J Poelarends, Robbert H Cool
The HLA class II histocompatibility antigen gamma chain, also known as HLA-DR antigen-associated invariant chain or CD74, has been shown to be involved in many biological processes amongst which antigen loading and transport of MHC class II molecules from the endoplasmic reticulum to the Golgi complex. It is also part of a receptor complex for Macrophage Migration Inhibitory Factor (MIF), and participates in inflammatory signaling. The inhibition of MIF-CD74 complex formation is regarded as a potentially attractive therapeutic target in inflammation, cancer and immune diseases...
March 27, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29599771/fresh-evidence-for-platelets-as-neuronal-and-innate-immune-cells-their-role-in-the-activation-differentiation-and-deactivation-of-th1-th17-and-tregs-during-tissue-inflammation
#6
REVIEW
Eugene D Ponomarev
Recent studies suggest that in addition to their common function in the regulation of thrombosis and hemostasis, platelets also contribute to tissue inflammation affecting adaptive immunity. Platelets have a number of pro-inflammatory and regulatory mediators stored in their α-granules and dense granules, which are promptly released at sites of inflammation or tissue injury. Platelet-derived mediators include cytokines (IL-1α, IL-1β, and TGFβ1), chemokines (CXCL4 and CCL3), immunomodulatory neurotransmitters (serotonin, dopamine, epinephrine, histamine, and GABA), and other low-molecular-weight mediators...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29552867/mechanisms-of-allergic-diseases-in-otorhinolaryngology
#7
E Ridolo, I Martignago, S Masieri
Allergic Rhinitis (AR) is an IgE-mediated hypersensitivity disease caused by inhalation of an allergen to which the patients is sensitized. Etiopathogenesis of AR comprises a sensitization phase, an immediate phase and a late phase. In the sensitization phase, inhaled allergens are processed in peptides and come into contact with the nasal mucosa cells. Antigen-Presenting Cells (APCs), especially represented by Dendritic Cells (DCs), capture them through the interaction with their own MHC class II complexes and migrate to lymph nodes...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29497361/silencing-alpha-synuclein-in-mature-nigral-neurons-results-in-rapid-neuroinflammation-and-subsequent-toxicity
#8
Matthew J Benskey, Rhyomi C Sellnow, Ivette M Sandoval, Caryl E Sortwell, Jack W Lipton, Fredric P Manfredsson
Human studies and preclinical models of Parkinson's disease implicate the involvement of both the innate and adaptive immune systems in disease progression. Further, pro-inflammatory markers are highly enriched near neurons containing pathological forms of alpha synuclein (α-syn), and α-syn overexpression recapitulates neuroinflammatory changes in models of Parkinson's disease. These data suggest that α-syn may initiate a pathological inflammatory response, however the mechanism by which α-syn initiates neuroinflammation is poorly understood...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29481982/il10-promoter-haplotypes-may-contribute-to-altered-cytokine-expression-and-systemic-inflammation-in-celiac-disease
#9
S R Hofmann, M W Laass, A Fehrs, D Schuppan, V F Zevallos, D Salminger, K Mäbert, C M Hedrich
Celiac disease (CD) is an autoimmune/inflammatory condition triggered by dietary gluten intake in genetically predisposed individuals. Though associations with MHC class II HLA-DQ2 or -DQ8 are the primary and necessary genetic predisposition for CD, >97% of genetically predisposed individuals never develop CD. Cytokines were measured in the serum of CD patients and controls. Possible associations with IL10 promoter variants were investigated. Cytokine expression from PBMCs was monitored in response to gluten exposure, or CD3/TCR complex stimulation in the absence or presence of recombinant IL-10...
February 23, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29476963/lps-mediated-cell-surface-expression-of-cd74-promotes-the-proliferation-of-b-cells-in-response-to-mif
#10
Christina Klasen, Tamar Ziehm, Michael Huber, Yaw Asare, Aphrodite Kapurniotu, Idit Shachar, Jürgen Bernhagen, Omar El Bounkari
Macrophage migration inhibitory factor (MIF) is a chemokine-like inflammatory cytokine, which plays a pivotal role in the pathogenesis of inflammatory and cardiovascular diseases as well as cancer. We previously identified MIF as a novel B cell chemokine that promotes B cell migration through non-cognate interaction with the CXC chemokine receptor CXCR4 and CD74, the surface form of MHC class II invariant chain. In this study, we have analyzed the regulation of the MIF receptors under inflammatory conditions by investigating the impact of lipopolysaccharide (LPS), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) on CD74 and CXCR4 expression in B lymphocytes...
February 21, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29475506/immunohistochemical-characterization-of-gastrointestinal-macrophages-phagocytes-in-dogs-with-inflammatory-bowel-disease-ibd-and-non-ibd-dogs
#11
Anna Wagner, Johannes Junginger, Frederik Lemensieck, Marion Hewicker-Trautwein
Intestinal Mϕ play a pivotal role in the maintenance of gut homeostasis, but can also contribute to inflammation such as inflammatory bowel disease (IBD). In contrast to human tissues, little is known about phenotypes of Mϕ in the canine gastrointestinal tract. Therefore, an immunohistochemical study was performed using Abs against Mϕ-associated molecules (Cluster of differentiation (CD)64, CD163, CD204, ionized calcium-binding adaptor molecule 1, L1 Ag, and MHC II) on stomach, duodenum, jejunum, ileum and colon from non-IBD dogs...
March 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29467328/allograft-dendritic-cell-p40-homodimers-activate-donor-reactive-memory-cd8-t-cells
#12
Hidetoshi Tsuda, Charles A Su, Toshiaki Tanaka, Katayoun Ayasoufi, Booki Min, Anna Valujskikh, Robert L Fairchild
Recipient endogenous memory T cells with donor reactivity pose an important barrier to successful transplantation and costimulatory blockade-induced graft tolerance. Longer ischemic storage times prior to organ transplantation increase early posttransplant inflammation and negatively impact early graft function and long-term graft outcome. Little is known about the mechanisms enhancing endogenous memory T cell activation to mediate tissue injury within the increased inflammatory environment of allografts subjected to prolonged cold ischemic storage (CIS)...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29456540/kallikrein-kinin-system-suppresses-type-i-interferon-responses-a-novel-pathway-of-interferon-regulation
#13
Alecia Seliga, Michael Hweemoon Lee, Nicole C Fernandes, Viviana Zuluaga-Ramirez, Marta Didukh, Yuri Persidsky, Raghava Potula, Stefania Gallucci, Uma Sriram
The Kallikrein-Kinin System (KKS), comprised of kallikreins (klks), bradykinins (BKs) angiotensin-converting enzyme (ACE), and many other molecules, regulates a number of physiological processes, including inflammation, coagulation, angiogenesis, and control of blood pressure. In this report, we show that KKS regulates Type I IFN responses, thought to be important in lupus pathogenesis. We used CpG (TLR9 ligand), R848 (TLR7 ligand), or recombinant IFN-α to induce interferon-stimulated genes (ISGs) and proteins, and observed that this response was markedly diminished by BKs, klk1 (tissue kallikrein), or captopril (an ACE inhibitor)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29446738/how-do-dendritic-cells-play-the-role-in-ischemia-reperfusion-triggered-kidney-allograft-rejection
#14
Songjie Cai, Naotsugu Ichimaru, Shiro Takahara
In deceased donors, ischemia/reperfusion injury (IRI) is an important cause of allograft dysfunction. Prolonged cold and warm ischemia time leads to a high risk of early post-transplant complications, including acute and chronic rejection. Ischemia not only up-regulates inflammatory cytokines and chemokines, but also enhances the expression of MHC-class II and adhesion molecules on epithelial and dendritic cells. Moreover, the danger associated molecular patterns (DAMPs) released from stressed or dying cells, not only cause or amplify tissue inflammation and trigger tissue repair in response to IRI, but also act as adjuvants that enhance DC maturation and potentiate the adaptive immune response...
February 13, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29405379/mucosal-associated-invariant-t-cells-in-autoimmune-and-immune-mediated-diseases
#15
Ophélie Rouxel, Agnès Lehuen
Autoimmune and inflammatory diseases have complex etiologies not fully understood. Both innate and adaptive immune cells are involved in the pathogenesis of these diseases. Mucosal-associated invariant (MAI)T cells express an invariant TCRα chain (Vα7.2-Jα33 in humans and Vα19-Jα33 in mice) and recognize the conserved MHC-I related molecule MR1 presenting bacterial metabolites derived from the synthesis of vitamin B. MAIT cells harbor tissue homing properties and produce inflammatory cytokines suggesting that MAIT cells may play a key role in autoimmune and inflammatory diseases...
February 6, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29393209/therapeutic-role-for-tsp-2-antibody-in-a-murine-asthma-model
#16
Kai Li, En Ping Huang, Jin Su, Ping Zhu, Jun Lin, Shen Qiu Luo, Cui Lan Yang
BACKGROUND: Specific immunotherapy, including agonists for Toll-like receptor 2 (TLR2), have been shown to protect from allergies and to have a high immunomodulatory capacity. METHODS: A new antibody, TSP-2, reactive against an epitope of the extracellular domain of TLR2, was identified. The effect of the antibody on dendritic cells was assessed by immunohistochemistry, Western blot, and flow cytometric analysis. The effect of TSP-2 in a murine asthma model induced with ovalbumin (OVA) was assessed...
January 27, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29376889/batf-dependent-il-7rhigm-csf-t-cells-control-intestinal-graft-versus-host-disease
#17
Evelyn Ullrich, Benjamin Abendroth, Johanna Rothamer, Carina Huber, Maike Büttner-Herold, Vera Buchele, Tina Vogler, Thomas Longerich, Sebastian Zundler, Simon Völkl, Andreas Beilhack, Stefan Rose-John, Stefan Wirtz, Georg F Weber, Sakhila Ghimire, Marina Kreutz, Ernst Holler, Andreas Mackensen, Markus F Neurath, Kai Hildner
Acute graft-versus-host disease (GVHD) represents a severe, T cell-driven inflammatory complication following allogeneic hematopoietic cell transplantation (allo-HCT). GVHD often affects the intestine and is associated with a poor prognosis. Although frequently detectable, proinflammatory mechanisms exerted by intestinal tissue-infiltrating Th cell subsets remain to be fully elucidated. Here, we show that the Th17-defining transcription factor basic leucine zipper transcription factor ATF-like (BATF) was strongly regulated across human and mouse intestinal GVHD tissues...
January 29, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29363184/functional-differences-in-airway-dendritic-cells-determine-susceptibility-to-ige-sensitization
#18
Jonatan Leffler, Kyle T Mincham, Danny Mok, Fabian Blank, Patrick G Holt, Philip A Stumbles, Deborah H Strickland
Respiratory IgE-sensitization to innocuous antigens increases the risk for developing diseases such as allergic asthma. Dendritic cells (DC) residing in the airways orchestrate the immune response following antigen exposure and their ability to sample and present antigens to naïve T cells in airway draining lymph nodes contributes to allergen-specific IgE-sensitization. In order to characterize inhaled antigen capture and presentation by DC subtypes in vivo, we used an adjuvant-free respiratory sensitization model using two genetically distinct rat strains, one of which is naturally resistant and the other naturally susceptible to allergic sensitization...
March 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29361739/human-mhc-ii-with-shared-epitope-motifs-are-optimal-epstein-barr-virus-glycoprotein-42-ligands-relation-to-rheumatoid-arthritis
#19
REVIEW
Nicole Trier, Jose Izarzugaza, Anna Chailyan, Paolo Marcatili, Gunnar Houen
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder of unknown etiology, which is characterized by inflammation in the synovium and joint damage. Although the pathogenesis of RA remains to be determined, a combination of environmental (e.g., viral infections) and genetic factors influence disease onset. Especially genetic factors play a vital role in the onset of disease, as the heritability of RA is 50-60%, with the human leukocyte antigen (HLA) alleles accounting for at least 30% of the overall genetic risk...
January 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29358051/non-classical-immunity-controls-microbiota-impact-on-skin-immunity-and-tissue-repair
#20
Jonathan L Linehan, Oliver J Harrison, Seong-Ji Han, Allyson L Byrd, Ivan Vujkovic-Cvijin, Alejandro V Villarino, Shurjo K Sen, Jahangheer Shaik, Margery Smelkinson, Samira Tamoutounour, Nicholas Collins, Nicolas Bouladoux, Amiran Dzutsev, Stephan P Rosshart, Jesse H Arbuckle, Chyung-Ru Wang, Thomas M Kristie, Barbara Rehermann, Giorgio Trinchieri, Jason M Brenchley, John J O'Shea, Yasmine Belkaid
Mammalian barrier surfaces are constitutively colonized by numerous microorganisms. We explored how the microbiota was sensed by the immune system and the defining properties of such responses. Here, we show that a skin commensal can induce T cell responses in a manner that is restricted to non-classical MHC class I molecules. These responses are uncoupled from inflammation and highly distinct from pathogen-induced cells. Commensal-specific T cells express a defined gene signature that is characterized by expression of effector genes together with immunoregulatory and tissue-repair signatures...
February 8, 2018: Cell
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