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https://www.readbyqxmd.com/read/29218605/oxymatrine-sensitizes-the-hacat-cells-to-the-ifn-%C3%AE-pathway-and-downregulates-mdc-icam-1-and-socs1-by-activating-p38-jnk-and-akt
#1
Chun-Jie Gao, Pei-Jun Ding, Li-Li Yang, Xu-Feng He, Meng-Jiao Chen, Dong-Ming Wang, Yan-Xin Tian, Hui-Min Zhang
Decreased interferon (IFN)-γ levels and increased levels of macrophage-derived chemokine (MDC) and intercellular adhesion molecule (ICAM)-1 are known to be involved in allergic skin diseases, such as eczema and atopic dermatitis. Activation of the IFN-γ and its downstream interleukin-12 (IL-12) pathway can correct these diseases. Suppressor of cytokine signaling 1 (SOCS1) is a cytokine signaling inhibitor that blocks downstream pathways of IFN-γ by blocking the mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) signaling pathways...
December 7, 2017: Inflammation
https://www.readbyqxmd.com/read/29202144/best-uses-of-osteopathic-manipulation
#2
Andrew H Slattengren, Tanner Nissly, Jodi Blustin, Andrew Bader, Erin Westfall
With the growing number of DOs and the high utilization of osteopathic manipulative treatment (OMT), it is important for all physicians to understand the role OMT can play in the treatment of conditions ranging from low back pain to irritable bowel syndrome so that patients may be offered, or referred for, the treatment when appropriate.
December 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/29200050/a-call-for-compassionate-care
#3
Karen Alexander
The Substance Abuse and Mental Health Services Administration (2014) reported that 1.1% of pregnant women used nonprescription opiates (either heroin or prescription pills) in the last 30 days. Methadone and buprenorphine are the most common treatments for opiate addiction in pregnant women. Reasons for seeking opiate maintenance treatment (OMT) include keeping custody of one's children and the hope of developing a healthy parenting relationship. Yet, healthcare organizations and professionals have mixed opinions regarding health promotion within the maternal OMT population...
October 2017: Journal of Addictions Nursing
https://www.readbyqxmd.com/read/29181525/omt-for-patients-with-multiple-sclerosis
#4
Kimberly Wolf, Tracy Krinard, Joel Talsma, Stacey Pierce-Talsma
No abstract text is available yet for this article.
December 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29161956/percutaneous-repair-of-mitral-valve-regurgitation-in-patients-with-severe-heart-failure-comparison-with-optimal-medical-treatment
#5
Nicolas Geis, Philip Raake, Markus Lewening, Derliz Mereles, Emmanuel Chorianopoulos, Lutz Frankenstein, Hugo A Katus, Raffi Bekeredjian, Sven T Pleger
BACKGROUND: Occurrence of severe mitral valve (MV) regurgitation (MR) is an independent negative predictor of mortality in patients with severe systolic heart failure (HF). This study examines clinical effects and cardiac reverse remodelling in patients with severe systolic HF receiving percutaneous mitral valve repair (PMVR) using MitraClip in comparison to patients receiving optimal medical therapy only. METHODS: Between 2010 and 2014, 86 patients (Society of Thoracic Surgeons score: 10...
November 21, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29151028/variations-in-use-of-optimal-medical-therapy-in-patients-with-nonobstructive-coronary-artery-disease-a-population-based-study
#6
Adam Oxner, Gabby Elbaz-Greener, Feng Qui, Shannon Masih, Nevena Zivkovic, Sami Alnasser, Asim N Cheema, Harindra C Wijeysundera
BACKGROUND: There is a paucity of data on the need for optimal medical therapy (OMT) in nonobstructive coronary artery disease . We sought to understand if there was variation in the use of OMT between hospitals for patients with nonobstructive coronary artery disease, the factors associated with such variation, and its clinical consequences. METHODS AND RESULTS: Using a population-level clinical registry in Ontario, Canada, we identified all patients >66 years undergoing coronary angiography for the indication of stable angina, who had nonobstructive coronary artery disease between November 1, 2010, and October 31, 2013...
November 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29150754/detoxification-of-aflatoxin-b1-by-antifungal-compounds-from-lactobacillus-brevis-and-lactobacillus-paracasei-isolated-from-dairy-products
#7
Eman Zakaria Gomaa, Manal Farouk Abdelall, Omima Mohammed El-Mahdy
Aflatoxins are a large group of highly toxic, mutagenic, and carcinogenic mycotoxins produced by specific species of fungi. Potential contamination of food commodities by these compounds causes extensive damage that lead to great economic losses. This study explored the potential use of antifungal compounds, produced by Lactobacillus brevis and Lactobacillus paracasei, for growth inhibition and subsequent aflatoxin B1 production from select strains of Aspergillus flavus and Aspergillus parasiticus. Lactobacilli strains were isolated from traditional Egyptian dairy products, whereas fungal strains were isolated from infected cereal seeds...
November 18, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29138270/low-and-high-renin-heart-failure-phenotypes-with-clinical-implications
#8
Noemi Pavo, Georg Goliasch, Raphael Wurm, Johannes Novak, Guido Strunk, Mariann Gyöngyösi, Marko Poglitsch, Marcus D Säemann, Martin Hülsmann
BACKGROUND: Blockade of the renin-angiotensin system (RAS) represents a main strategy in the therapy of heart failure with reduced ejection fraction (HFrEF), but the role of active renin concentration (ARC) for guiding therapy in the presence of an RAS blockade remains to be established. This study assessed angiotensin profiles of HFrEF patients with distinct RAS activations as reflected by ARC. METHODS: Two cohorts of stable chronic HFrEF patients on optimal medical treatment (OMT) were enrolled...
November 14, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29124952/current-management-and-treatment-of-patients-with-stable-coronary-artery-diseases-presenting-to-cardiologists-in-different-clinical-contexts-a-prospective-observational-nationwide-study
#9
Leonardo De Luca, Pier Luigi Temporelli, Donata Lucci, Lucio Gonzini, Carmine Riccio, Furio Colivicchi, Giovanna Geraci, Dario Formigli, Patrizia Maras, Colomba Falcone, Andrea Di Lenarda, Michele Massimo Gulizia
Background Stable coronary artery disease (CAD) is a leading cause of mortality worldwide. Few studies document the complete sequence of investigation of the overall stable CAD population during outpatient visits or hospitalisation. Aim To obtain accurate and up-to-date information on current management of patients with stable CAD. Methods START (STable coronary Artery diseases RegisTry) was a prospective, observational, nationwide study aimed at evaluating the presentation, management, treatment and quality of life of stable CAD patients presenting to cardiologists during outpatient visits or discharged from cardiology wards...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29107215/oxymatrine-protects-against-dss-induced-colitis-via-inhibiting-the-pi3k-akt-signaling-pathway
#10
Qianyun Chen, Xueyun Duan, Heng Fan, Meng Xu, Qing Tang, Lijuan Zhang, Zhexing Shou, Xingxing Liu, Dongmei Zuo, Jia Yang, Shuangjiao Deng, Yalan Dong, Hui Wu, Yujin Liu, Zhen Nan
Oxymatrine (OMT), an alkaloid derived from the root of the Sophora flavescens, has been reported to possess a significant effect on relieving UC owing to its anti-inflammatory property. But the other therapeutic mechanism of OMT remains unclear. Recent studies have found, PI3K/AKT signaling pathway is involved in the pathogenesis of UC by pro-inflammatory effects and activating T cells. Moreover, PI3K/AKT pathway is one of the most important pathways for regulating cell apoptosis. Thus, we aim to explore whether OMT protects against UC by targeting PI3K/AKT pathway...
October 26, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29101775/outpatient-satisfaction-with-osteopathic-manipulative-treatment-in-a-hospital-center-a-survey
#11
Marco Tramontano, Alex Martino Cinnera, Marco Petracca, Angela Gaeta, Federica Tamburella, Maurice Audouard, Carlo Caltagirone
Context • Although osteopathy is not yet certified as a health profession in Italy, many people choose osteopathic manipulative treatment (OMT) for pain relief. Nevertheless, no study evaluating patients' degree of satisfaction after OMT and the perceived quality of the treatment has occurred in Italy. Objectives • The study intended to assess outpatients' satisfaction with OMT carried out at a hospital. Design • The research team conducted a survey from January 2015 to January 2016 using 3 questionnaires...
October 28, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29097746/quality-of-medical-therapy-in-heart-failure-patients-undergoing-elective-revascularisation-a-protective-effect-of-disease-modifying-therapy-at-discharge
#12
Raphael Wurm, Martin Huelsmann, Marius Hienert, Veronika Seidl, Dominik Wiedemann, Guenther Laufer, Alfred Kocher, Christopher Adlbrecht, Martin Andreas
The STICH(-ES) trial showed that coronary artery bypass grafting was superior to medical therapy alone in treating ischemic heart failure. However, dosages of disease modifying drugs were not reported. We included 128 (84% male, mean age 66 ± 11 years) consecutive patients with ischemic heart failure and an ejection fraction ≤35% undergoing isolated elective coronary artery bypass grafting. We defined optimal medical therapy (OMT) as prescription of ≥50% dosages of guideline recommended medications (i...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29096661/willingness-to-receive-intravenous-buprenorphine-treatment-in-opioid-dependent-people-refractory-to-oral-opioid-maintenance-treatment-results-from-a-community-based-survey-in-france
#13
Perrine Roux, Daniela Rojas Castro, Khadim Ndiaye, Laélia Briand Madrid, Virginie Laporte, Marion Mora, Gwenaelle Maradan, Stéphane Morel, Bruno Spire, Patrizia Carrieri
BACKGROUND: Injectable opioids are an interesting option for people who inject drugs (PWID) that do not respond to oral Opioid Maintenance Treatment (OMT). To date, intravenous (IV) buprenorphine - a safer drug than full-opioid agonists in terms of overdose risk - has never been tested in a clinical trial on opioid dependence. We designed a survey to better understand the profile of PWID eligible for IV buprenorphine, and their willingness to receive it. METHODS: This cross-sectional community-based national survey was conducted through face-to-face interviews (in low-threshold and addiction care services) and online questionnaires (on https://psychoactif...
November 2, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/29080454/the-synergy-of-diammonium-glycyrrhizinate-remarkably-reduces-the-toxicity-of-oxymatrine-in-icr-mice
#14
Hui-Juan Shi, Hong-Bin Song, Le Wang, Sheng-Xiang Xiao, Kai-Ping Bo, Wei Ma
Most traditional Chinese medicine prescription dosages are imprecise. This study analyzes the toxicities and adverse effects of a combination the active ingredients of licorice and Kushen medicine: oxymatrine (OMT) and diammonium glycyrrhizinate (DG). The median lethal dose (LD50) and mortality were analyzed in single-dose OMT (or DG) intraperitoneally injected mice with or without combination DG (or OMT). Body weight changes as well as levels of serum sodium and potassium, alanine transaminase (ALT), aspartate transaminase (AST), creatinine, and urea were measured in mice treated with a daily dose of OMT and/or DG for 14days...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29055633/colchicine-therapy-and-plaque-stabilization-in-patients-with-acute%C3%A2-coronary-syndrome-a-ct-coronary-angiography-study
#15
Kaivan Vaidya, Clare Arnott, Gonzalo J Martínez, Bernard Ng, Samuel McCormack, David R Sullivan, David S Celermajer, Sanjay Patel
OBJECTIVES: The authors sought to evaluate the plaque-modifying effects of low-dose colchicine therapy plus optimal medical therapy (OMT) in patients post-acute coronary syndrome (ACS), as assessed by coronary computed tomography angiography (coronary CTA). BACKGROUND: Colchicine therapy has been postulated to have beneficial anti-inflammatory effects in patients with ACS, translating into reduction in future adverse cardiovascular events. However, whether favorable plaque modification underpins this is yet unproven...
October 14, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29049469/effectiveness-of-injectable-extended-release-naltrexone-vs-daily-buprenorphine-naloxone-for-opioid-dependence-a-randomized-clinical-noninferiority-trial
#16
Lars Tanum, Kristin Klemmetsby Solli, Zill-E-Huma Latif, Jurate Šaltyte Benth, Arild Opheim, Kamni Sharma-Haase, Peter Krajci, Nikolaj Kunøe
Importance: To date, extended-release naltrexone hydrochloride has not previously been compared directly with opioid medication treatment (OMT), currently the most commonly prescribed treatment for opioid dependence. Objective: To determine whether treatment with extended-release naltrexone will be as effective as daily buprenorphine hydrochloride with naloxone hydrochloride in maintaining abstinence from heroin and other illicit substances in newly detoxified individuals...
December 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29043664/substrate-scope-of-o-methyltransferase-from-streptomyces-peucetius-for-biosynthesis-of-diverse-natural-products-methoxides
#17
Prakash Parajuli, Ramesh Prasad Pandey, Thi Huyen Trang Nguyen, Dipesh Dhakal, Jae Kyung Sohng
Methylation is a common post-modification reaction that is observed during the biosynthesis of secondary metabolites produced by plants and microorganisms. Based on the sequence information from Streptomyces peucetius ATCC27952, a putative O-methyltransferase (OMT) gene SpOMT7740 was polymerase chain reaction amplified and cloned into E. coli BL21 (DE3) host to test the substrate promiscuity and conduct functional characterization. In vitro and in vivo reaction assays were carried out over various classes of substrates: flavonoids (flavonol, flavones, and isoflavonoid), chalcones, anthraquinones, anthracyclines, and sterol molecules, and the applications in synthesizing diverse classes of O-methoxy natural products were also illustrated...
October 18, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29037641/impact-of-osteopathic-therapy-on-proprioceptive-balance-and-quality-of-life-in-patients-with-dizziness
#18
L Papa, A Amodio, F Biffi, A Mandara
The aim of the study was to evaluate the efficacy of osteopathic manipulative treatment (OMT) in patients with Benign-Paroxysmal-Positional Vertigo (BPPV). Thirty-one patients with BPPV were randomly assigned into two groups: 19 patients received osteopathic treatments (TG) and 12 patients received sham therapy (SG), both in four weekly sessions. Before the first and the last treatment, those patients were evaluated using Dizziness Handicap Inventory (DHI) and stabilometric platform to assess lifestyle modification and balance functions...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29037623/osteopathic-manipulative-treatment-for-low-back-and-pelvic-girdle-pain-during-and-after-pregnancy-a-systematic-review-and-meta-analysis
#19
Helge Franke, Jan-David Franke, Sebastian Belz, Gary Fryer
BACKGROUND: Low back pain (LBP) is a common complaint during pregnancy. This study examined the effectiveness of osteopathic manipulative treatment (OMT) for LBP in pregnant or postpartum women. METHODS: Randomized controlled trials unrestricted by language were reviewed. Outcomes were pain and functional status. Mean difference (MD) or standard mean difference (SMD) and overall effect size were calculated. RESULTS: Of 102 studies, 5 examined OMT for LBP in pregnancy and 3 for postpartum LBP...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29020337/refining-the-prognostic-impact-of-functional-mitral-regurgitation-in-chronic-heart-failure
#20
Georg Goliasch, Philipp E Bartko, Noemi Pavo, Stephanie Neuhold, Raphael Wurm, Julia Mascherbauer, Irene M Lang, Guido Strunk, Martin Hülsmann
Aims: Significant efforts are currently undertaken to reduce functional mitral regurgitation (FMR) in patients with chronic heart failure in the hope to improve prognosis. We aimed to assess the prognostic impact of FMR in heart failure with reduced ejection fraction (HFrEF) under optimal medical therapy (OMT) and various conditions of HFrEF. We further intended to identify a heart failure phenotype, where FMR is most likely a driving force and not a mere bystander of the disease. Methods and results: We prospectively included 576 consecutive HFrEF patients into our long-term observational study...
July 25, 2017: European Heart Journal
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