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https://www.readbyqxmd.com/read/28100664/rab1-interacts-with-golph3-and-controls-golgi-structure-and-contractile-ring-constriction-during-cytokinesis-in-drosophila-melanogaster
#1
Stefano Sechi, Anna Frappaolo, Roberta Fraschini, Luisa Capalbo, Marco Gottardo, Giorgio Belloni, David M Glover, Alan Wainman, Maria Grazia Giansanti
Cytokinesis requires a tight coordination between actomyosin ring constriction and new membrane addition along the ingressing cleavage furrow. However, the molecular mechanisms underlying vesicle trafficking to the equatorial site and how this process is coupled with the dynamics of the contractile apparatus are poorly defined. Here we provide evidence for the requirement of Rab1 during cleavage furrow ingression in cytokinesis. We demonstrate that the gene omelette (omt) encodes the Drosophila orthologue of human Rab1 and is required for successful cytokinesis in both mitotic and meiotic dividing cells of Drosophila melanogaster We show that Rab1 protein colocalizes with the conserved oligomeric Golgi (COG) complex Cog7 subunit and the phosphatidylinositol 4-phosphate effector GOLPH3 at the Golgi stacks...
January 2017: Open Biology
https://www.readbyqxmd.com/read/28097476/impact-of-an-exercise-training-program-on-cardiac-neuronal-function-in-heart-failure-patients-on-optimal-medical-therapy-a-randomized-iodine-123-metaiodobenzylguanidine-scintigraphy-study
#2
Torstein Valborgland, Kjetil Isaksen, Peter Scott Munk, Zbigniew Piotr Grabowski, Alf Inge Larsen
BACKGROUND: The syndrome of heart failure (HF) is characterized by left ventricular dysfunction and a compensatory chronic over activation of the sympathetic nervous system. We wanted to investigate if the beneficial effects of exercise training (ET) in HF patients on optimal medical therapy (OMT) are associated with alterations in cardiac sympathetic activity. METHODS: Cardiac sympathetic activity was evaluated at baseline and after 12 weeks using metaiodobenzylguanidine scintigraphy in 23 patients with stable HF participating in the SmartEx trial...
January 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28024988/delayed-villous-maturation-in-term-placentas-exposed-to-opioid-maintenance-therapy-a-retrospective-cohort-study
#3
Allison E Serra, Lara S Lemon, Neggin B Mokhtari, W Tony Parks, Janet M Catov, Raman Venkataramanan, Steve N Caritis
BACKGROUND: Opioid use disorder among pregnant women is associated with adverse perinatal outcomes and is increasing in the U.S. The standard of care for pregnant women with OUD is opioid maintenance therapy (OMT) including either methadone or buprenorphine, which can be initiated at any time during pregnancy. These medications are known to cross the placenta but their placental and fetal effects have not been well characterized. Delayed villous maturation, a placental finding associated with stillbirth, was observed in placentas exposed to opioid maintenance therapy...
December 23, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28001273/effect-of-speech-language-therapy-after-low-level-laser-therapy-in-patients-with-tmd-a-descriptive-study
#4
Melissa de Oliveira Melchior, Bárbara Cristina Zanandréa Machado, Lais Valencise Magri, Marcelo Oliveira Mazzetto
Increased pain and/or discomfort during chewing, speaking, and swallowing have been commonly reported by patients with Temporomandibular Dysfunction (TMD). Speech-language pathology therapy (orofacial myofunctional therapy - OMT) has been proposed as part of the treatment for this condition; however, it is a modality that should be introduced when the TMD context and the pain are not accentuated, so that they do not prevent or hinder the performance of exercises. The aim of this study was to analyze the effect of OMT on the treatment of patients with TMD, according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), after analgesia with low-level laser therapy (LLLT), regarding orofacial myofunctional conditions (OMC) and the perception of TMD symptoms...
November 2016: CoDAS
https://www.readbyqxmd.com/read/27993908/implantable-cardioverter-defibrillator-for-non-ischemic-cardiomyopathy-an-updated-meta-analysis
#5
Harsh Golwala, Navkaranbir Singh Bajaj, Garima Arora, Pankaj Arora
Use of Implantable cardioverter-defibrillators (ICD) have been a major advancement in patients with ischemic cardiomyopathy (ICM) with reduced ejection fraction <35%.(1) While the data supporting the use of ICDs are robust in patients with ICM, limited randomized controlled clinical trial (RCT) data exist for similar benefit in patients with non-ischemic cardiomyopathy (NICM).(2) A prior meta-analysis that included both primary and secondary prevention ICD trials in 2004 by Desai et al. demonstrated a 31% reduction in all-cause mortality with ICD use in patients with NICM...
December 19, 2016: Circulation
https://www.readbyqxmd.com/read/27957818/optimal-pharmacological-treatment-and-adherence-to-medication-in-secondary-prevention-of-cardiovascular-events-in-spain-results-from-the-caps-study
#6
Alberto Cordero, Luis Rodriguez Padial, Alberto Batalla, Luis López Barreiro, Francisco Torres Calvo, Jose M Castellano, Emilio Ruiz, Vicente Bertomeu-Martínez
INTRODUCTION: Despite the large amount of evidence supporting the use of antiplatelet agents, beta-blockers, angiotensin antagonists, and lipid-lowering statins in patients with stable coronary artery disease, several studies have documented underprescription of optimal medical treatment (OMT) in Spain. AIMS: The present study aims to describe the current trend of pharmacological prescription in secondary prevention treatment for cardiovascular diseases (CVD) in a Spanish cohort...
December 13, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27957488/oxymatrine-inhibits-proliferation-and-migration-while-inducing-apoptosis-in-human-glioblastoma-cells
#7
Feili Liu, Baocheng Wang, Jiajia Wang, Xiaozheng Ling, Qifeng Li, Wei Meng, Jie Ma
Oxymatrine (OMT), an alkaloid derived from the traditional Chinese medicine herb Sophora flavescens Aiton, has been shown to exhibit anticancer properties on various types of cancer cells. In this study, we investigate the anticancer properties of OMT on human glioblastoma (GBM) cells and evaluate their underlying mechanisms. MTT assays were performed and demonstrated that OMT significantly inhibits the proliferation of GBM cells. Flow cytometry suggested that OMT at a concentration of 10(-5) M may induce apoptosis in U251 and A172 cells...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27956817/a-systematic-review-of-orthopaedic-manual-therapy-randomized-clinical-trials-quality
#8
Sean P Riley, Brian Swanson, Jean-Michel Brismée, Steven F Sawyer
Study Design: Systematic review and meta-analysis. Objectives: To conduct a systematic review and meta-analysis of randomized clinical trials (RCTs) in the orthopaedic manual therapy (OMT) literature from January 2010 to June 2014 in order to determine if the CONSORT checklist and Cochrane Risk of Bias (RoB) assessment tools: (1) are reliable; (2) have improved the reporting and decreased the risk of bias in RCTs in the OMT literature; (3) differ based on journal impact factor (JIF); and (4) scores are associated with each other...
December 2016: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/27897164/hmgb1-mediated-autophagy-decreases-sensitivity-to-oxymatrine-in-sw982-human-synovial-sarcoma-cells
#9
Yongsong Cai, Peng Xu, Le Yang, Ke Xu, Jialin Zhu, Xiaoqing Wu, Congshan Jiang, Qiling Yuan, Bo Wang, Yuanbo Li, Yusheng Qiu
Oxymatrine (OMT) is a type of alkaloid extracted from a traditional Chinese medicinal herb, Sophora flavescens. Although the antitumor activities of OMT have been observed in various cancers, there are no reports regarding the effects of OMT on human synovial sarcoma. In the present study, we analyzed the antitumor activities of OMT in SW982 human synovial sarcoma cells and determine whether high mobility group box protein 1 (HMGB1)-mediated autophagy was associated with its therapeutic effects. We found that OMT exhibited antitumor activity in SW982 cells and facilitated increases in autophagy...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893148/osteopathic-manipulative-treatment-for-somatic-dysfunction-after-acute-severe-traumatic-brain-injury
#10
Adrienne McCallister, Christopher Brown, Michael Smith, Hugh Ettlinger, Gerard A Baltazar
Somatic dysfunction caused by traumatic brain injury (TBI) may be managed by osteopathic manipulative treatment (OMT). In this case report, the authors describe 2 patients with severe TBI who were each treated with OMT in a level-1 regional trauma center. Both patients received OMT beginning in the acute care phase of injury. Somatic dysfunction improved during the course of treatment, and no adverse effects of OMT were noted. More comprehensive research may clarify the efficacy and adverse effects of OMT as part of multimodal acute care of patients with severe TBI...
December 1, 2016: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/27893142/assessment-of-hospital-staff-s-knowledge-of-osteopathic-manipulative-medicine-a-survey-based-study
#11
Jessica B Smith-Kelly, Andres Cardenas
CONTEXT: Research has shown that osteopathic manipulative treatment (OMT) in hospitalized patients can shorten hospital length of stay. However, hospital staff may be unfamiliar with OMT and its use in this setting. OBJECTIVE: To assess a hospital staff's knowledge of osteopathic manipulative medicine (OMM) and investigate whether there is a correlation between job category and knowledge of OMM. METHODS: The study used a 13-item survey that was developed using SurveyMonkey...
December 1, 2016: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/27884241/a-prospective-natural-history-study-of%C3%A2-coronary-atherosclerosis-using-fractional-flow-reserve
#12
Emanuele Barbato, Gabor G Toth, Nils P Johnson, Nico H J Pijls, William F Fearon, Pim A L Tonino, Nick Curzen, Zsolt Piroth, Gilles Rioufol, Peter Jüni, Bernard De Bruyne
BACKGROUND: In patients with coronary artery disease, clinical outcome depends on the extent of reversible myocardial ischemia. Whether the outcome also depends on the severity of the stenosis as determined by fractional flow reserve (FFR) remains unknown. OBJECTIVES: This study sought to investigate the relationship between FFR values and vessel-related clinical outcome. METHODS: We prospectively studied major adverse cardiovascular events (MACE) at 2 years in 607 patients in whom all stenoses were assessed by FFR and who were treated with medical therapy alone...
November 29, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27882228/oxymatrine-inhibits-microglia-activation-via-hsp60-tlr4-signaling
#13
Feijia Ding, Yunhong Li, Xiaolin Hou, Rui Zhang, Shuting Hu, Yin Wang
Oxymatrine (OMT) is an alkaloid extracted from Sophora flavescens, which has broad anti-inflammatory, antitumor and immunosuppressant actions. However, the underlying molecular mechanisms have remained elusive. Heat shock protein 60 (HSP60) has recently been shown to have an important role in autoimmune reactions. The present study aimed to investigate whether OMT exerts its anti-inflammatory effects by inhibiting microglial activation and examined the role of HSP60 in this process. Western blot analysis and ELISA showed that OMT decreased the expression and release of HSP60 by LPS-activated BV2 cells...
November 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27858681/the-effect-of-visceral-osteopathic-manual-therapy-applications-on-pain-quality-of-life-and-function-in-patients-with-chronic-nonspecific-low-back-pain
#14
Seval Tamer, Müzeyyen Öz, Özlem Ülger
BACKGROUND: The efficacy of osteopathic manual therapy (OMT) applications on chronic nonspecific low back pain (LBP) has been demonstrated. However, visceral applications, which are an important part of OMT techniques, have not been included in those studies. OBJECTIVE: The study's objective was to determine the effect of OMT including visceral applications on the function and quality of life (QoL) in patients with chronic nonspecific LBP. DESIGN: The study was designed with a simple method of block randomization...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27852531/osteopathic-manipulative-treatment-a-systematic-review-and-critical-appraisal-of-comparative-effectiveness-and-health-economics-research
#15
REVIEW
Amie Steel, Tobias Sundberg, Rebecca Reid, Lesley Ward, Felicity L Bishop, Matthew Leach, Holger Cramer, Jon Wardle, Jon Adams
In recent years, evidence has emerged regarding the effectiveness of osteopathic manipulative treatments (OMT). Despite growing evidence in this field, there is need for appropriate research designs that effectively reflect the person-centred system of care promoted in osteopathy and provide data which can inform policy decisions within the healthcare system. The purpose of this systematic review is to identify, appraise and synthesise the evidence from comparative effectiveness and economic evaluation research involving OMT...
October 29, 2016: Manual Therapy
https://www.readbyqxmd.com/read/27823911/-trend-in-buprenorphine-and-methadone-shopping-behavior-in-france-from-2004%C3%A2-to-2014
#16
Mélanie Kernisant, Jessica Delorme, Jean-Luc Kabore, Georges Brousse, Catherine Laporte, Marie Zenut, Chouki Chenaf, Nicolas Authier
INTRODUCTION: The opioid maintenance treatments (OMT) are widely misused and diverted in many countries. Doctor shopping represented the main way to obtain high quantities of opioids in abuse/diversion. The aim of this study was to assess the trends in the prevalence of doctor shopping for high dosage buprenorphine (HDB) and methadone (MTD) from 2004 to 2014 by using the French Health Insurance claims. METHODS: This was a cross-sectional study of patients treated by OMT (High Dosage Buprenorphine or Methadone) between 2004 and 2014 from a representative sample of the French Health Insurance claims...
December 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27803090/percutaneous-coronary-intervention-choice-decision-aid-for-stable-coronary-artery-disease-a-randomized-trial
#17
Megan Coylewright, Sara Dick, Becky Zmolek, Jason Askelin, Edward Hawkins, Megan Branda, Jonathan W Inselman, Claudia Zeballos-Palacios, Nilay D Shah, Erik P Hess, Annie LeBlanc, Victor M Montori, Henry H Ting
BACKGROUND: Percutaneous coronary intervention (PCI) for stable coronary artery disease does not reduce the risk of death and myocardial infarction compared with optimal medical therapy (OMT), but many patients think otherwise. PCI Choice, a decision aid (DA), was designed for use during the clinical visit and includes information on quality of life and mortality outcomes for PCI with OMT versus OMT alone for stable coronary artery disease. METHODS AND RESULT: We conducted a randomized trial to assess the impact of the PCI Choice DA compared with usual care when there is a choice between PCI and optimal medical therapy...
November 1, 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27802898/oxymatrine-attenuated-isoproterenol-induced-heart-failure-in-rats-via-regulation-of-cox-2-pgi2-pathway
#18
Ru Zhou, Qingbin Xu, Yehua Xu, Aiqin Xiong, Yang Wang, Ping Ma
Oxymatrine (OMT) is an active constituent of traditional Chinese herb Sophora japonica Ait which has been shown to exert potent anti-inflammatory,anti-oxidant and anti-fibrosis properties. Our previous studies have demonstrated that OMT has protective effects on isoproterenol-induced heart failure in rats through regulation of DDAH/ADMA metabolism pathway.In this study,we further investigated whether OMT could attenuate isoproterenol-induced heart failure through the regulation of COX-2/PGI2 pathway. Heart failure was induced in Sprague-Dawley rats by 5mg/kg isoproterenol subcutaneous injection for 7days...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27802558/does-replacing-live-demonstration-with-instructional-videos-improve-student-satisfaction-and-osteopathic-manipulative-treatment-examination-performance
#19
Ryan Seals, Sharon M Gustowski, Carol Kominski, Feiming Li
CONTEXT: Instructional videos for osteopathic manipulative treatment (OMT) are a potentially valuable resource for novice learners. OBJECTIVE: To evaluate student experiences and the effectiveness of instructional videos in lieu of live faculty demonstration in a second-year osteopathic manipulative medicine course. METHODS: Faculty created and produced written instructions and videos for selected Still and facilitated positional release techniques...
November 1, 2016: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/27802557/pregnancy-research-on-osteopathic-manipulation-optimizing-treatment-effects-the-promote-study-protocol
#20
Kendi L Hensel, Michael S Carnes, Scott T Stoll
The structural and physiologic changes in a woman's body during pregnancy can predispose pregnant women to low back pain and its associated disability, as well as to complications of pregnancy, labor, and delivery. Anecdotal and empirical evidence has indicated that osteopathic manipulative treatment (OMT) may be efficacious in improving pain and functionality in women who are pregnant. Based on that premise, the Pregnancy Research on Osteopathic Manipulation Optimizing Treatment Effects (PROMOTE) study was designed as a prospective, randomized, placebo-controlled, and blinded clinical trial to evaluate the efficacy of an OMT protocol for pain during third-trimester pregnancy...
November 1, 2016: Journal of the American Osteopathic Association
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