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https://www.readbyqxmd.com/read/29049469/the-effectiveness-of-injectable-extended-release-naltrexone-vs-daily-buprenorphine-naloxone-for-opioid-dependence-a-randomized-clinical-noninferiority-trial
#1
Lars Tanum, Kristin Klemmetsby Solli, Zill-E-Huma Latif, Jurate Šaltyte Benth, Arild Opheim, Kamni Sharma-Haase, Peter Krajci, Nikolaj Kunøe
Importance: To date, extended-release naltrexone hydrochloride has not previously been compared directly with opioid medication treatment (OMT), currently the most commonly prescribed treatment for opioid dependence. Objective: To determine whether treatment with extended-release naltrexone will be as effective as daily buprenorphine hydrochloride with naloxone hydrochloride in maintaining abstinence from heroin and other illicit substances in newly detoxified individuals...
October 18, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29043664/substrate-scope-of-o-methyltransferase-from-streptomyces-peucetius-for-biosynthesis-of-diverse-natural-products-methoxides
#2
Prakash Parajuli, Ramesh Prasad Pandey, Thi Huyen Trang Nguyen, Dipesh Dhakal, Jae Kyung Sohng
Methylation is a common post-modification reaction that is observed during the biosynthesis of secondary metabolites produced by plants and microorganisms. Based on the sequence information from Streptomyces peucetius ATCC27952, a putative O-methyltransferase (OMT) gene SpOMT7740 was polymerase chain reaction amplified and cloned into E. coli BL21 (DE3) host to test the substrate promiscuity and conduct functional characterization. In vitro and in vivo reaction assays were carried out over various classes of substrates: flavonoids (flavonol, flavones, and isoflavonoid), chalcones, anthraquinones, anthracyclines, and sterol molecules, and the applications in synthesizing diverse classes of O-methoxy natural products were also illustrated...
October 18, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29037641/impact-of-osteopathic-therapy-on-proprioceptive-balance-and-quality-of-life-in-patients-with-dizziness
#3
L Papa, A Amodio, F Biffi, A Mandara
The aim of the study was to evaluate the efficacy of osteopathic manipulative treatment (OMT) in patients with Benign-Paroxysmal-Positional Vertigo (BPPV). Thirty-one patients with BPPV were randomly assigned into two groups: 19 patients received osteopathic treatments (TG) and 12 patients received sham therapy (SG), both in four weekly sessions. Before the first and the last treatment, those patients were evaluated using Dizziness Handicap Inventory (DHI) and stabilometric platform to assess lifestyle modification and balance functions...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29037623/osteopathic-manipulative-treatment-for-low-back-and-pelvic-girdle-pain-during-and-after-pregnancy-a-systematic-review-and-meta-analysis
#4
Helge Franke, Jan-David Franke, Sebastian Belz, Gary Fryer
BACKGROUND: Low back pain (LBP) is a common complaint during pregnancy. This study examined the effectiveness of osteopathic manipulative treatment (OMT) for LBP in pregnant or postpartum women. METHODS: Randomized controlled trials unrestricted by language were reviewed. Outcomes were pain and functional status. Mean difference (MD) or standard mean difference (SMD) and overall effect size were calculated. RESULTS: Of 102 studies, 5 examined OMT for LBP in pregnancy and 3 for postpartum LBP...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29020337/refining-the-prognostic-impact-of-functional-mitral-regurgitation-in-chronic-heart-failure
#5
Georg Goliasch, Philipp E Bartko, Noemi Pavo, Stephanie Neuhold, Raphael Wurm, Julia Mascherbauer, Irene M Lang, Guido Strunk, Martin Hülsmann
Aims: Significant efforts are currently undertaken to reduce functional mitral regurgitation (FMR) in patients with chronic heart failure in the hope to improve prognosis. We aimed to assess the prognostic impact of FMR in heart failure with reduced ejection fraction (HFrEF) under optimal medical therapy (OMT) and various conditions of HFrEF. We further intended to identify a heart failure phenotype, where FMR is most likely a driving force and not a mere bystander of the disease. Methods and results: We prospectively included 576 consecutive HFrEF patients into our long-term observational study...
July 25, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28972897/simultaneous-adsorption-of-aflatoxin-b1-and-zearalenone-by-mono-and-di-alkyl-cationic-surfactants-modified-montmorillonites
#6
Gaofeng Wang, Yushan Miao, Zhiming Sun, Shuilin Zheng
Organo-montmorillonites (OMts) modified with mono- and di-alkyl cationic surfactants were prepared to remove polar mycotoxin aflatoxin B1 (AFB1) and weak polar, hydrophobic mycotoxin zearalenone (ZER) simultaneously. The structural and surface properties of the prepared OMts were investigated. In vitro adsorption experiments were carried out to simulate the in vivo conditions of gastrointestinal tract of animals by a batch mode. The adsorption of AFB1 and ZER in both single and binary-contaminate systems were investigated systematically...
September 25, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28959845/-effect-of-oxymatrine-on-apoptosis-of-hippocampal-neurons-by-p38-jnk-signaling-pathway
#7
Yan Cai, Wei Jiang, Ai-Ling Zhou, Min Zhou, Ling Xu
To investigate the effect and mechanism of oxymatrine(OMT) on hippocampal neurons apoptosis. Effect of OMT on survival of hippocampal neurons was measured by MTT.Effect of OMT on LPS-induced lactate dehydrogenase(LDH) release rate in hippocampal neurons was measured by biochemical methods. Hoechst 33342 staining was used to observe the apoptotic morphology of hippocampal neurons.The mRNA expression levels of Bax, Bcl-2, and Caspase-3 were detected by Real-time quantitative PCR(RT-qPCR), and the protein expression levels of p38, p-p38, JNK, p-JNK, Bax, Bcl-2 and Caspase-3 were detected by Western blot...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936280/enhancing-diffusion-mri-measures-by-integrating-grey-and-white-matter-morphometry-with-hyperbolic-wasserstein-distance
#8
Wen Zhang, Jie Shi, Jun Yu, Liang Zhan, Paul M Thompson, Yalin Wang
In order to improve the preclinical diagnose of Alzheimer's disease (AD), there is a great deal of interest in analyzing the AD related brain structural changes with magnetic resonance image (MRI) analyses. As the major features, variation of the structural connectivity and the cortical surface morphometry provide different views of structural changes to determine whether AD is present on presymptomatic patients. However, the large scale tensor-valued information and relatively low imaging resolution in diffusion MRI (dMRI) have created huge challenges for analysis...
2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/28922749/unraveling-additional-o-methylation-steps-in-benzylisoquinoline-alkaloid-biosynthesis-in-california-poppy-eschscholzia-californica
#9
Ratmoyo Purwanto, Kentaro Hori, Yasuyuki Yamada, Fumihiko Sato
California poppy (Eschscholzia californica), a member of the Papaveraceae family, produces many biologically active benzylisoquinoline alkaloids (BIAs), such as sanguinarine, macarpine and chelerythrine. Sanguinarine biosynthesis has been elucidated at the molecular level, and its biosynthetic genes have been isolated and used in synthetic biology approaches to produce BIAs in vitro. However, several genes involved in the biosynthesis of macarpine and chelerythrine have not yet been characterized. In this study, we report the isolation and characterization of a novel O-methyltransferase (OMT) involved in the biosynthesis of partially characterized BIAs, especially chelerythrine...
September 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28869181/-impact-of-osteopathic-manipulative-therapy-in-patient-with-deep-with-colorectal-endometriosis-a-classification-based-on-symptoms-and-quality-of-life
#10
C Daraï, S Bendifallah, H Foulot, M Ballester, N Chabbert-Buffet, E Daraï
OBJECTIVES: A prospective study to evaluate the clinical impact of osteopathic manipulative therapy (OMT) on symptoms and quality of life (QOL) of patients with colorectal endometriosis. METHODS: Forty-six patients with colorectal endometriosis completed the SF-36 QOL and symptoms questionnaire before and after OMT. A comparison and clustering analysis was performed to identify subgroups of patient's profile and symptom classification. RESULTS: The mean age of the patients was 32±6...
August 28, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28862008/-olfactory-function-in-patients-undergoing-fess-for-chronic-rhinosinusitis
#11
Zdeněk Knížek, Jan Vodička, Pavlína Brothánková, Hana Shejbalová
Patients with chronic rhinosinusitis (CRS) often suffer from loss of olfactory function. Rhinosinusitis can be treated either by medical therapy or surgically (FESS). Postoperative outcome in terms of improving sense of smell has been controversial so far. The aim of our study was to determine the patients who would have better postoperative outcomes in terms of improving olfactory function. We collected data of patients undergoing FESS for chronic rhinosinusitis (either with or without nasal polyps) at our department during the years 2012-2015...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28849213/inhibitory-effects-of-oxymatrine-on-tgf%C3%A2-%C3%AE-1%C3%A2-induced-proliferation-and-abnormal-differentiation-in-rat-cardiac-fibroblasts-via-the-p38mapk-and-erk1-2-signaling-pathways
#12
Yini Xu, Hai Xiao, Hong Luo, Yan Chen, Yanyan Zhang, Ling Tao, Yan Jiang, Yuqi Chen, Xiangchun Shen
Interstitial fibrosis serves a causal role in the development of heart failure following acute and chronic myocardial infarction, and anti‑fibrotic therapy represents a promising strategy to mitigate this pathological process. Oxymatrine (OMT) exerts a number of pharmacological effects on the cardiovascular system, but its anti‑cardiovascular disease mechanisms remain unclear. The purpose of the present study was to investigate the effect of OMT administration on transforming growth factor (TGF)‑β1‑induced cardiac fibroblast (CFB) proliferation and abnormal differentiation, and to elucidate the underlying mechanisms...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28846126/progressive-infantile-scoliosis-managed-with-osteopathic-manipulative-treatment
#13
Richard A Feely, Holly E Kapraun
Infantile idiopathic scoliosis is a compensatory result of cranial and sacral intraosseous dysfunction associated with asymmetric developmental deformation of the occiput, leading to dysfunction of the sphenobasilar synchondrosis. A female infant with progressive infantile idiopathic scoliosis diagnosed at age 12 months (46.9° left scoliotic curve) initially received standard orthopedic care, including casting. The patient presented for osteopathic evaluation at age 14 months, at which time her scoliotic curve was 52°...
September 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28846123/osteopathic-manipulative-treatment-to-manage-ophthalmic-conditions
#14
Tatyana Sherman, Yasmin Qureshi, Austin Bach
Although there is little evidence-based literature regarding osteopathic manipulative treatment for ophthalmic conditions, the general principles and techniques of osteopathic manipulative medicine can be used to manage various ophthalmic pathologic conditions. Additional research to support these treatment options and evaluate the role of OMT as a potential conservative treatment option used by ophthalmologists is needed.
September 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28846122/single-osteopathic-manipulative-therapy-session-dampens-acute-autonomic-and-neuroendocrine-responses-to-mental-stress-in-healthy-male-participants
#15
Mauro Fornari, Luca Carnevali, Andrea Sgoifo
Context: The efficacy of osteopathic manipulative therapy (OMTh; manipulative care provided by foreign-trained osteopaths) is supported by observational data and patient feedback, but there is still a need for objective, quantitative biomarkers that allow measurement of the underlying mechanisms. No study exploring the protective potential of OMTh for mental stress has been published, to the authors' knowledge. Objectives: To explore the modulating effect of OMTh on autonomic neural regulation of the heart and verifiy its ability to influence the activity of the hypothalmic-pituitary-adrenocortical axis...
September 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28844035/state-of-the-art-optimal-medical-therapy-competing-with-or-complementary-to-revascularisation-in-patients-with-coronary-artery-disease
#16
Javaid Iqbal, Robert Widmer, Bernard J Gersh
The role of coronary revascularisation with PCI and CABG in patients with stable and unstable coronary artery disease (CAD) is well established and there is a general consensus among guidelines as regards the indications for coronary revascularisation. Although revascularisation has undoubtedly revolutionised the treatment of CAD, it is vital to understand the recent advances and importance of the concomitant use of evidence-based optimal medical therapy (OMT). In contemporary practice, OMT should include an antiplatelet agent (or dual antiplatelet therapy when indicated) and a lipid-lowering drug for all patients, and a beta-blocker and an ACE inhibitor (or angiotensin receptor blocker) for the vast majority of patients, along with addressing cardiac risk factors and lifestyle management...
August 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28827016/acute-intramural-hematoma-of-the-descending-aorta-treated-with-stent-graft-repair-is-associated-with-a-better-prognosis
#17
Kaichuang Ye, Jinbao Qin, Minyi Yin, Mi'er Jiang, Weimin Li, Xinwu Lu
PURPOSE: To compare midterm outcomes of optimal medical treatment (OMT) alone with OMT and thoracic endovascular aortic repair (TEVAR) of acute type B intramural hematoma (IMHB). MATERIALS AND METHODS: Retrospective analysis was performed of 65 patients treated with OMT alone (31 patients) or OMT with TEVAR (34 patients) for acute uncomplicated or complicated IMHB from January 2006 to December 2015 in a single institution. Primary outcome was aortic-related mortality during follow-up...
October 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28826849/thoracic-epidural-anesthesia-reversed-myocardial-fibrosis-in-patients-with-heart-failure-caused-by-dilated-cardiomyopathy
#18
Dan Ma, Lei Liu, Hongwei Zhao, Ruiying Zhang, Fengxiang Yun, Lulu Li, Yang Wang, Renhai Qu, Pengfei Liu, Fengqi Liu
OBJECTIVE: To verify that high thoracic epidural anesthesia (TEA) could reverse myocardial fibrosis in heart failure caused by dilated cardiomyopathy (DCM). DESIGN: Hospitalized patients with DCM and heart failure. SETTING: Harbin Medical University, Harbin, Heilongjiang, China. PARTICIPANTS: Eight patients. INTERVENTIONS: 0.5% lidocaine was administered epidurally at the T4-T5 interspace for 4 weeks...
October 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28808371/efficacy-of-osteopathic-manipulative-treatment-approach-in-the-patient-with-pulmonary-fibrosis-in-critical-care-outpatient-department
#19
Manu Goyal, Kanu Goyal, Kanimozhi Narkeesh, Asir John Samuel, Narkeesh Arumugam, Subhasish Chatterjee, Sorabh Sharma
The purpose of the present case study was to explore the efficacy of osteopathic manipulative treatment (OMT) in patient with pulmonary fibrosis (PF) in the critical care outpatient department. Here, we present a 48-year-old male case with breathlessness, increased frequency of defecation, and pain in and around the nape of neck with diagnosed pulmonary fibrosis. He scored 3 on a patient-reported modified Medical Research Council (mMRC) dyspnea scale. Osteopathic examination reveals multiple somatic findings across the chest and abdominal region and treated by OMT...
July 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28798779/one-swallow-does-not-a-summer-make-but-many-swallows-do-accumulating-clinical-evidence-for-nearly-eliminated-peri-procedural-and-30-day-complications-with-mesh-covered-stents-transforms-the-carotid-revascularisation-field
#20
REVIEW
Piotr Musiałek, L Nelson Hopkins, Adnan H Siddiqui
Atherosclerotic carotid artery stenosis (CS) continues to be a common cause of acute ischaemic stroke. Optimised medical therapy (OMT), the first-line treatment modality in CS, may reduce or delay - but it does not abolish - CS-related strokes. As per current AHA/ASA and ESC/ESVS/ESO guidelines, carotid artery stenting (CAS) is a less-invasive alternative to carotid endarterectomy (CEA) for CS revascularisation in primary and secondary stroke prevention. Ten-year follow-up from the CREST trial in patients with symptomatic and asymptomatic CS confirmed equipoise of CAS and CEA in the primary endpoint...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
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