keyword
https://read.qxmd.com/read/38530892/neofunctionalization-of-an-omt-cluster-dominates-polymethoxyflavone-biosynthesis-associated-with-the-domestication-of-citrus
#1
JOURNAL ARTICLE
Zhaoxin Peng, Lizhi Song, Minghua Chen, Zeyang Liu, Ziyu Yuan, Huan Wen, Haipeng Zhang, Yue Huang, Zhaowen Peng, Hongbin Yang, Gu Li, Huixian Zhang, Zhehui Hu, Wenyun Li, Xia Wang, Robert M Larkin, Xiuxin Deng, Qiang Xu, Jiajing Chen, Juan Xu
Polymethoxyflavones (PMFs) are a class of abundant specialized metabolites with remarkable anticancer properties in citrus. Multiple methoxy groups in PMFs are derived from methylation modification catalyzed by a series of hydroxylases and O -methyltransferases (OMTs). However, the specific OMTs that catalyze the systematic O -methylation of hydroxyflavones remain largely unknown. Here, we report that PMFs are highly accumulated in wild mandarins and mandarin-derived accessions, while undetectable in early-diverging citrus species and related species...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38529043/effects-of-tongue-strength-training-on-patients-with-mild-to-moderate-sleep-disordered-breathing-a-randomized-controlled-trial
#2
JOURNAL ARTICLE
Junya Yoshioka, Tatsuya Nagano, Reina Sekiya, Chihiro Mimura, Hiroki Satoh, Takehiro Otoshi, Daisuke Hazama, Naoko Katsurada, Masatsugu Yamamoto, Motoko Tachihara, Yoshihiro Nishimura, Kazuyuki Kobayashi
OBJECTIVES: : Several studies have reported that oropharyngeal myofunctional therapy (OMT) reduces the severity of obstructive sleep apnea (OSA). However, because OMT protocols are often complicated, they take time and effort to implement. The aim of this study was to determine the therapeutic effect of 8 weeks of simple tongue strength training with a training device. METHODS: : Twenty patients with mild to moderate sleep-disordered breathing were randomized to the control group (n=10) or intervention group (n=10)...
2024: Progress in rehabilitation medicine
https://read.qxmd.com/read/38522001/the-short-and-long-term-effect-of-osteopathic-manipulative-treatment-on-pain-and-psychosocial-factors-in-adults-with-chronic-low-back-pain
#3
JOURNAL ARTICLE
Clarence L Nicodemus, Jessica Epstein, Marianne Huebner, Barry DeCicco, Moaid Shaik
CONTEXT: Chronic low back pain (CLBP) has long plagued mankind, but little progress has been made in finding a rational and effective treatment, let alone a common cause. This study is an attempt to fill that void by measuring short- and long-term effects of osteopathic manipulative treatment (OMT), including psychosocial and pain reduction in CLBP patients. OBJECTIVES: The objectives of this study were to investigate the effectiveness of neuromusculoskeletal medicine/osteopathic manipulative medicine (OMM) in treating CLBP, with a focus on biopsychosocial (pain sensitivity questionnaire [PSQ]) and pain control in chronic conditions...
March 25, 2024: Journal of osteopathic medicine
https://read.qxmd.com/read/38510744/prognostic-differences-between-physiology-guided-percutaneous-coronary-intervention-and-optimal-medical-therapy-in-coronary-artery-disease-a-systematic-review-and-meta-analysis
#4
REVIEW
Utsho Islam, Muhammad Sabbah, Burcu T Özbek, Jasmine M Madsen, Jacob T Lønborg, Thomas Engstrøm
BACKGROUND: Intracoronary physiology, particularly fractional flow reserve (FFR), has been used as a guide for revascularization for patients with coronary artery disease (CAD). The optimal treatment in the physiological grey-zone area has been unclear and remains subject to ongoing debate. METHODS: We conducted a systematic review of randomized controlled trials and observational studies comparing the prognostic effect of percutaneous coronary revascularization (PCI) and optimal medical therapy (OMT) in patients with CAD...
February 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38503643/utility-of-coronary-revascularization-in-patients-with-ischemic-left-ventricular-dysfunction
#5
REVIEW
Mohammed Al-Sadawi, Michael Tao, Simrat Dhaliwal, Archanna Radakrishnan, Yang Liu, Chad Gier, Ravi Masson, Tahmid Rahman, Edlira Tam, Noelle Mann
BACKGROUND: Revascularization in patients with left ventricular (LV) dysfunction has been a subject of ongoing uncertainty and conflicting results. This is further complicated by factors including viability, severity of LV dysfunction, and method of revascularization using percutaneous coronary intervention (PCI) versus coronary-artery bypass grafting (CABG). OBJECTIVES: The purpose of this meta-analysis is to evaluate the association of coronary revascularization with outcomes in patients with ischemic LV dysfunction...
March 5, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38503613/efficacy-and-safety-of-tongxin-formula-after-stent-implantation-for-acute-coronary-syndrome-a-multicenter-double-blind-placebo-controlled-randomized-trial
#6
JOURNAL ARTICLE
Wen Zhu, Su Wang, Lei Zhang, Feng-Qun Xie, Jie Cheng, Xian-Kai Li, Wei Chen, Shi-Yun Yan, Qi-Mao Feng
OBJECTIVE: The aim of this study is to comprehensively evaluate both the efficacy and safety profile of integrating the Tongxin formula with optimal medical therapy (OMT) for patients experiencing acute coronary syndromes subsequent to coronary stenting, over the course of one year. METHODS: We enrolled 150 patients diagnosed with acute coronary syndromes who had received stent placement within one month and exhibited a TCM syndrome characterized by Qi deficiency and blood stasis...
March 1, 2024: Explore: the Journal of Science and Healing
https://read.qxmd.com/read/38502206/does-cannabis-use-substitute-for-opioids-a-preliminary-exploratory-survey-in-opioid-maintenance-patients
#7
JOURNAL ARTICLE
Nina Kim Bekier, Ulrich Frischknecht, Katharina Eidenmueller, Franz Grimm, Patrick Bach, Manuel Stenger, Falk Kiefer, Derik Hermann
Various studies showed that people with substance use disorder use cannabis to reduce withdrawal or dose of their main drug. Using a questionnaire about their cannabis use, 118 participants in an opioid maintenance treatment (OMT) in Germany were examined regarding this strategy. 60% reported to use cannabis. Of those, 72% were using cannabis in the suggested way. Cannabis was used to substitute for, e.g., heroin (44.8%) and benzodiazepines (16.4%). We also asked for an estimation of how good cannabis was able to substitute for several substances (in German school grades (1 till 6)); heroin average grade: 2...
March 19, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38498320/mbeomt1-regulates-methyleugenol-biosynthesis-in-melaleuca-bracteata-f-muell
#8
JOURNAL ARTICLE
Chao Yang, Yongsheng Lin, Xuwen Xiang, Dandan Shao, Ziwen Qiu, Yongyu Li, Shaohua Wu
Methyleugenol, a bioactive compound in the phenylpropene family, undergoes its final and crucial biosynthetic transformation when eugenol O-methyltransferase (EOMT) converts eugenol into methyleugenol. While Melaleuca bracteata essential oil is particularly rich in methyleugenol, it contains only trace amounts of its precursor, eugenol. This suggests that the EOMT enzyme in M. bracteata is highly efficient, although it has not yet been characterized. In this study, we isolated and identified an EOMT gene from M...
March 18, 2024: Tree Physiology
https://read.qxmd.com/read/38497815/identification-and-characterization-of-two-o-methyltransferases-involved-in-methylated-2-2-phenethyl-chromones-biosynthesis-in-agarwood
#9
JOURNAL ARTICLE
Wenli Wu, Tingting Yan, Xiaochen Sun, Iain Wilson, Gaiyun Li, Zhou Hong, Fenjuan Shao, Deyou Qiu
The 2-(2-phenethyl)chromones (PECs) are the signature constituents responsible for the fragrance and pharmacological properties of agarwood. O-methyltransferases (OMTs) are necessary for the methylated PECs biosynthesis, however, there is little information known about OMTs in Aquilaria sinensis. In this study, we identified 29 OMT genes from the A. sinensis genome. Expression analysis showed they were differentially expressed in different tissues and responded to drill wounding. Comprehensive analysis of the gene expression and methylated PECs content revealed that the AsOMT2, AsOMT8, AsOMT11, AsOMT16, and AsOMT28 could potentially be involved in methylated PECs biosynthesis...
March 18, 2024: Journal of Experimental Botany
https://read.qxmd.com/read/38496085/osteopathic-manipulative-treatment-during-post-operative-recovery-a-scoping-review
#10
REVIEW
Chandler G Randall, Heather A Paul, Heather Lumley, Angelica Ortega, Jace Rowley, Bailey Brown, Sukanya Mohan, Kristina Smith, Thomas Messer, Emily Swan, Rohit S Mehra
Surgery is a common and often necessary treatment option for a wide range of medical conditions, with an estimated 40 to 50 million surgeries performed in the US alone each year. While the various types of surgeries performed may be effective in treating or managing different conditions, the post-operative period can be challenging for patients. Osteopathic manipulative treatment (OMT) is a hands-on approach to medical care that seeks to restore balance and harmony to the body from the lens of an interconnected mind, body, and spirit...
February 2024: Curēus
https://read.qxmd.com/read/38488211/osteopathic-manipulative-treatment-for-chronic-inflammatory-diseases
#11
REVIEW
Ross Gillan, Gabrielle Bachtel, Kassidy Webber, Yasmine Ezzair, Nicole E Myers, Anupam Bishayee
Chronic inflammatory diseases (CIDs) are debilitating and potentially lethal illnesses that affect a large proportion of the global population. Osteopathic manipulative treatment (OMT) is a manual therapy technique developed and performed by osteopathic physicians that facilitates the body's innate healing processes. Therefore, OMT may prove a beneficial anti-inflammatory modality useful in the management and treatment of CIDs. This work aims to objectively evaluate the therapeutic benefits of OMT in patients with various CIDs...
March 15, 2024: Journal of Evidence-based Medicine
https://read.qxmd.com/read/38486733/percutaneous-coronary-intervention-versus-optimal-medical-therapy-for-stable-coronary-artery-disease-an-umbrella-review
#12
JOURNAL ARTICLE
David R Soriano-Moreno, Daniel Fernandez-Guzman, Kimberly G Tuco, Anderson N Soriano-Moreno, Fabricio Ccami-Bernal, Abdiel H Coico-Lama, Antony G Gonzáles-Uribe, Alvaro Taype-Rondan
BACKGROUND: Invasive management of stable coronary artery disease is still a controversial topic. The purpose of this umbrella review was to synthesize systematic reviews (SRs) that evaluate the benefits and harms of percutaneous coronary intervention (PCI) versus optimal medical therapy (OMT) in patients with stable coronary artery disease. METHODS: We systematically searched PubMed/MEDLINE, Embase, and CENTRAL from 2018 to August 7, 2022. We included SRs with meta-analyses of randomized controlled trials (RCTs) that evaluated the question of interest...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38481881/osteopathic-manipulative-treatment-for-chronic-neck-stiffness-after-a-motor-vehicle-collision-a-case-report
#13
Jennifer M Jost, Veenah K Stoll, Holly B Waters
Neck pain is a multifactorial condition, and one common cause is cervical spine injury related to motor vehicle collision (MVC). Injuries from MVCs range from whiplash to cervical spine fracture and can manifest in various ways including neck stiffness, decreased range of motion, and neurological deficits. One method of management currently underutilized is osteopathic manipulative treatment (OMT), which can be used to treat pain and range of motion deficits resulting from MVCs. While a few studies in the literature have documented a statistically significant benefit of OMT in chronic pain syndromes, there is little data on its effectiveness in treating patients after MVCs...
February 2024: Curēus
https://read.qxmd.com/read/38481254/patient-s-and-healthcare-provider-s-experiences-with-opioid-maintenance-treatment-omt-a-qualitative-evidence-synthesis
#14
JOURNAL ARTICLE
Asbjørn Steiro, Christine Hillestad Hestevik, Ashley Elizabeth Muller
BACKGROUND: Opioid Maintenance Treatment (OMT) is the gold standard for people with opioid dependence. However, drop-out rates are high, and many patients do not reach desired outcomes. Understanding patients' and healthcare providers' experiences with the treatment can provide valuable information to improve the quality of OMT and to increase acceptability and accessibility of services. The aim of this systematic review is to explore and synthesise the experiences of OMT among persons with opioid dependence and health care providers, to inform policy makers and practitioners on how to improve OMT outcomes...
March 13, 2024: BMC Health Services Research
https://read.qxmd.com/read/38474023/use-of-3-deoxy-d-arabino-heptulosonic-acid-7-phosphate-synthase-dahp-synthase-to-enhance-the-heterologous-biosynthesis-of-diosmetin-and-chrysoeriol-in-an-engineered-strain-of-streptomyces-albidoflavus
#15
JOURNAL ARTICLE
Álvaro Pérez-Valero, Juan Serna-Diestro, Claudio J Villar, Felipe Lombó
Flavonoids are a large family of polyphenolic compounds with important agro-industrial, nutraceutical, and pharmaceutical applications. Among the structural diversity found in the flavonoid family, methylated flavonoids show interesting characteristics such as greater stability and improved oral bioavailability. This work is focused on the reconstruction of the entire biosynthetic pathway of the methylated flavones diosmetin and chrysoeriol in Streptomyces albidoflavus . A total of eight different genes (TAL, 4CL, CHS, CHI, FNS1, F3'H/CPR, 3'-OMT, 4'-OMT) are necessary for the heterologous biosynthesis of these two flavonoids, and all of them have been integrated along the chromosome of the bacterial host...
February 28, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38467778/efflux-pump-inhibitor-phenylalanine-arginine-beta-naphthylamide-analog-potentiates-the-activity-of-5-o-mycaminosyltylonolide-for-multi-drug-resistant-pseudomonas-aeruginosa
#16
JOURNAL ARTICLE
Aoi Kimishima, Masako Honsho, Junsei Terai, Paul Wasuwanich, Sota Honma, Hidehito Matsui, Hideaki Hanaki, Yukihiro Asami
The emergence and spread of antimicrobial resistance are global threats. Pseudomonas aeruginosa (P. aeruginosa) is responsible for a substantial proportion of this global health issue because of its intrinsic resistance to many antibiotics due to the impermeability of its outer membrane and its multidrug efflux pump systems. Therefore, therapeutic drugs are limited, and the development of new drugs is extremely challenging. As an alternative approach, we focused on a combinational treatment strategy and found that 5-O-mycaminosyltylonolide (OMT) showed potent antibacterial activity against P...
March 11, 2024: Journal of Antibiotics
https://read.qxmd.com/read/38462720/a-novel-o-and-s-methyltransferase-from-pleurotus-sapidus-is-involved-in-flavor-formation
#17
JOURNAL ARTICLE
Fabio Francesco Brescia, Lukas Korf, Lars-Oliver Essen, Holger Zorn, Martin Ruehl
Increasing consumer aversion to non-natural flavoring substances is prompting a heightened interest in enzymatic processes for flavor production. This includes methylation reactions, which are often performed by using hazardous chemicals. By correlation of aroma profile data and transcriptomic analysis, a novel O -methyltransferase (OMT) catalyzing a respective reaction within the formation of p -anisaldehyde was identified in the mushroom Pleurotus sapidus . Heterologous expression in E. coli followed by purification allowed for further characterization of the enzyme...
March 10, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38459458/the-changes-of-blood-based-inflammatory-biomarkers-after-non-pharmacologic-interventions-for-chronic-low-back-pain-a-systematic-review
#18
JOURNAL ARTICLE
Laura Maria Puerto Valencia, Yangyang He, Pia-Maria Wippert
BACKGROUND: Chronic low back pain (CLBP) is a prevalent and debilitating condition, leading to significant challenges to both patients and the governmental healthcare system. Non-pharmacologic interventions have received increasing attention as potential strategies to alleviate chronic low back pain and improve patient outcomes. The aim of this systematic review was to comprehensively assess the changes in blood inflammatory biomarkers after non-pharmacologic interventions for CLBP patients, thus trying to understand the complex interactions between non-pharmacologic interventions and inflammatory biomarker changes in CLBP...
March 8, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38456564/intrauterine-exposure-to-maternal-opioid-maintenance-treatment-and-associated-risk-factors-may-impair-child-growth
#19
JOURNAL ARTICLE
Minna Kanervo, Liina Luoto, Sarimari Tupola, Eeva Nikkola, Hanna Kahila, Krista Rantakari
AIM: How maternal opioid maintenance treatment (OMT) affects children is under-researched. This population-based registry study investigated child growth and somatic health following intrauterine exposure to this treatment. METHODS: Children born between 1 March 2011 and 30 May 2021 to mothers who used buprenorphine, buprenorphine-naloxone, or methadone throughout their pregnancies were followed for 2 years at the Helsinki University Hospital, Finland. Appropriate statistical tests were used to compare the treatment groups...
March 8, 2024: Acta Paediatrica
https://read.qxmd.com/read/38452473/molecular-insights-into-gastric-cancer-the-impact-of-tgfbr2-and-hsa-mir-107-revealed-by-microarray-sequencing-and-bioinformatics
#20
JOURNAL ARTICLE
Zhengsen Jin, Zhihong Huang, Chao Wu, Fanqin Zhang, Yifei Gao, Siyu Guo, Xiaoyu Tao, Shan Lu, Jingyuan Zhang, Jiaqi Huang, Yiyan Zhai, Rui Shi, Peizhi Ye, Jiarui Wu
BACKGROUND: Gastric carcinoma (GC) remains a significant therapeutic challenge, garnering widespread attention. Oxymatrine (OMT), an active component of the traditional Chinese medicine compound Kushen injection (CKI), has shown promising results in combination with chemotherapy for the treatment of GC. However, the molecular mechanisms underlying OMT's therapeutic effects in GC have yet to be elucidated. METHODS: The transcriptomic expression data of HGC-27 post-OMT intervention were obtained through microarray sequencing, while the miRNA and mRNA sequencing data for GC patients were sourced from the TCGA database...
March 2, 2024: Computers in Biology and Medicine
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