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https://www.readbyqxmd.com/read/29915609/identification-and-characterization-of-genes-involved-in-benzylisoquinoline-alkaloid-biosynthesis-in-coptis-species
#1
Si-Mei He, Yan-Li Liang, Kun Cong, Geng Chen, Xiu Zhao, Qi-Ming Zhao, Jia-Jin Zhang, Xiao Wang, Yang Dong, Jian-Li Yang, Guang-Hui Zhang, Zhi-Long Qian, Wei Fan, Sheng-Chao Yang
The dried rhizomes of Coptis chinensis have been extensively used in heat clearing, dampness drying, fire draining, and detoxification by virtue of their major bioactive components, benzylisoquinoline alkaloids (BIAs). However, C. teeta and C. chinensis are occasionally interchanged, and current understanding of the molecular basis of BIA biosynthesis in these two species is limited. Here, berberine, coptisine, jatrorrhizine, and palmatine were detected in two species, and showed the highest contents in the roots, while epiberberine were found only in C...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29912782/a-randomized-triple-blind-trial-of-cardiac-shock-wave-therapy-on-exercise-tolerance-and-symptoms-in-patients-with-stable-angina-pectoris
#2
Evgeny Shkolnik, Greta Burneikaite, Gabrielius Jakutis, Mikhail Scherbak, Gitana Zuoziene, Birute Petrauskiene, Ekaterina Trush, Yury Vasyuk, Aleksandras Laucevicius, Jelena Celutkiene
BACKGROUND: Despite major advances in managing coronary artery disease and continuous research on alternative techniques to enhance myocardial perfusion and reduce symptoms, coronary artery disease is still one of the leading causes of adult disability worldwide. Cardiac shock-wave therapy (CSWT) has shown promising results in the amelioration of myocardial ischemia in experimental studies; however, clinical results are limited to single-center, mostly uncontrolled and underpowered trials...
June 16, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29910054/treatment-of-sleep-disordered-breathing-in-heart-failure-impacts-cardiac-remodeling-insights-from-the-cat-hf-trial
#3
Melissa A Daubert, David J Whellan, Holger Woehrle, Gudaye Tasissa, Kevin J Anstrom, JoAnn Lindenfeld, Adam Benjafield, Amy Blase, Naresh Punjabi, Mona Fiuzat, Olaf Oldenburg, Christopher M O'Connor
BACKGROUND: Sleep-disordered breathing (SDB), including central and obstructive sleep apnea, is a marker of poor prognosis in heart failure (HF) and may worsen cardiac dysfunction over time. Treatment of SDB with adaptive servoventilation (ASV) may reverse pathologic cardiac remodeling in HF patients. METHODS: The Cardiovascular Improvements with Minute Ventilation-targeted Adaptive Servo-Ventilation Therapy in Heart Failure (CAT-HF) trial randomized patients with acute decompensated HF and confirmed SDB to either optimal medical therapy (OMT) or treatment with ASV and OMT...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29903654/anti-pruritic-and-anti-inflammatory-effects-of-oxymatrine-in-a-mouse-model-of-allergic-contact-dermatitis
#4
Xiaoyun Xu, Wei Xiao, Zhe Zhang, Jianhao Pan, Yixi Yan, Tao Zhu, Dan Tang, Kaihe Ye, Manish Paranjpe, Lintao Qu, Hong Nie
BACKGROUND: Allergic contact dermatitis (ACD) is a highly prevalent inflammatory disease of the skin. As a result of the complex etiology in ACD, therapeutic compounds targeting refractory pruritus in ACD lack efficacy and lead to numerous side effects. OBJECTIVE: In this study, we investigated the anti-pruritic effects of oxymatrine (OMT) and explored its mechanism of action in a mouse model of ACD. METHOD: 72 male SPF C57BL/6 mice were randomly divided into control group, ACD model group, dexamethasone positive control group (0...
May 31, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29898588/role-of-rehabilitation-in-the-elderly-after-an-acute-event-insights-from-a-real-life-prospective-study-in-the-sub-acute-care-setting
#5
Gianluigi Galizia, Giulio Balestrieri, Beatrice De Maria, Cinzia La Storia, Mauro Monelli, Stefano Salvaderi, Giuseppe Romanelli, Laura A Dalla Vecchia
BACKGROUND: Any acute event, either primary or secondary to a chronic disease, is generally followed by some degree of physical impairment. The Sub-Acute Care (SAC) represents one of the inpatient intermediate care settings aimed at completing recovery and restoring functional capacity. Debate exists on the role of the rehabilitation treatment in the SAC setting. AIM: To compare the outcomes of patients managed in two different SAC Units where A) patients undergo an individualized rehabilitation program on top of optimal medical therapy (OMT) B) patients receive OMT only...
June 11, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29870325/-anxiety-and-depression-in-chronic-heart-failure-what-can-a-cardiologist-do
#6
V Y Mareev, M Y Drobizhev, Y L Begrambekova
AIM: To reveal the probability and duration of the onset of remission of anxiety-depressive symptoms in patients with CHF III-IV receiving optimal medicine treatment (OMT) or (OMT), supplemented with the education program and active outpatient monitoring (OMT + A). MATERIALS AND METHODS: A secondary analysis of the results of RCT CHANCE, which studied the impact of the training program and active outpatient control (further additional exposure (DV) plus optimal medication (OMT) on mortality and cardiovascular hospitalization in patients with CHF III-IV FC...
May 2018: Kardiologiia
https://www.readbyqxmd.com/read/29866172/evaluation-of-day-care-versus-inpatient-cataract-surgery-performed-at-a-jiangsu-public-tertiary-a-hospital
#7
Min Zhuang, Juan Cao, Minglan Cui, Songtao Yuan, Qinghuai Liu, Wen Fan
BACKGROUND: High cataract incidence and low cataract surgical rate are serious public health problems in China, despite the fact that efficient day care cataract surgery has been implemented in some public Tertiary A hospitals in China. In this study, we compared not only clinical outcomes, hospitalization time and total costs but also payment manners between day care and inpatient procedures for cataract surgery in a Jiangsu public Tertiary A hospital to put forward several instructional suggestions for the improvement of government medical policies...
June 5, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29861270/impact-of-treatment-strategies-on-outcomes-in-patients-with-stable-coronary-artery-disease-and-type-2-diabetes-mellitus-according-to-presenting-angina-severity-a-pooled-analysis-of-three-federally-funded-randomized-trials
#8
G B John Mancini, William E Boden, Maria M Brooks, Helen Vlachos, Bernard R Chaitman, Robert Frye, Vera Bittner, Pamela M Hartigan, Gilles R Dagenais
BACKGROUND AND AIMS: The impact of treatment strategies on outcomes in patients with stable coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) according to presenting angina has not been rigorously assessed. METHODS: We performed a patient-level pooled-analysis (n = 5027) of patients with stable CAD and T2DM randomized to optimal medical therapy [OMT], percutaneous coronary intervention [PCI] + OMT, or coronary artery bypass grafting [CABG] + OMT...
May 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29861222/osteopathic-manual-therapy-in-heart-failure-patients-a-randomized-clinical-trial
#9
Sergio R Thomaz, Felipe A Teixeira, Alexandra C G B de Lima, Gerson Cipriano Júnior, Magno F Formiga, Lawrence Patrick Cahalin
BACKGROUND: Heart Failure (HF) patients usually present with increased arterial resistance and reduced blood pressure (BP) leading to an impaired functional capacity. Osteopathic Manual Therapy (OMT) focused on myofascial release techniques (MRT) and in the balancing of diaphragmatic tensions, has been shown to improve blood flow in individuals using the resistive index (RI). However, its effects in HF patients have not been examined. PURPOSE: To evaluate the acute response of selected osteopathic techniques on RI, heart rate (HR), and BP in patients with HF...
April 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29861220/successful-outcome-of-musculoskeletal-injury-leads-to-a-reduction-in-chronic-fatigue-a-case-report
#10
Carl Todd DO
BACKGROUND: Chronic fatigue syndrome (CFS) is a general term used to describe a number of medical conditions that lead to persistent levels of fatigue and distress. OBJECTIVES: Osteopathic manipulative treatment (OMT) combined with shoulder exercises to resolve musculoskeletal sports injury may have also led to a reduction in pain and improved strength with the patient reporting a change in CFS levels. CLINICAL FEATURES: 19-year-old male student, (statue 194cm and mass 80kg) who had played county level cricket and hockey...
April 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29861217/osteopathic-manipulative-treatment-in-chronic-coccydynia-a-case-series
#11
D Origo, A G Tarantino, A Nonis, L Vismara
BACKGROUND: Coccydynia is a disorder associated with pain/discomfort at the base of the spine. The role of osteopathic manipulative treatment (OMT) in chronic coccydynia as well as for low back pain (LBP) and radicular pain (RP) associated with coccydynia, has not previously been investigated. This study seeks to analyse the effects of OMT on chronic coccydynia compared to physical therapy and pharmacological treatment (PTPT). The secondary objective is to analyse the effect of OMT on LBP and RP associated with coccydynia...
April 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29850129/limited-prognostic-value-of-myocardial-viability-assessment-in-patients-with-coronary-artery-diseases-and-severe-left-ventricular-dysfunction
#12
Yihua Liu, Yefan Jiang, Xiaoxi Yang, Bingchuan Geng, Yi Liu, Xiaoke Shang, Jinping Liu, Xiaoli Lan, Nianguo Dong
Background: Myocardial viability assessment is typically performed in patients with coronary artery disease (CAD) and severe left ventricular (LV) dysfunction to identify those who might benefit from revascularization and assist in decision making process. However, the prognostic value of myocardial viability testing remains a debating issue. Methods: Positron Emission Tomography using 18 F-fluorodeoxyglucose (18 FDG-PET) was performed in 81 patients with ischemic LV dysfunction [ejection fraction (EF) ≤35%] for myocardial viability assessment prior to coronary artery bypass surgery...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29799457/monitoring-the-chemical-profile-in-agarwood-formation-within-one-year-and-speculating-on-the-biosynthesis-of-2-2-phenylethyl-chromones
#13
Ge Liao, Wen-Hua Dong, Jin-Ling Yang, Wei Li, Jun Wang, Wen-Li Mei, Hao-Fu Dai
Agarwood is highly valued for its uses as incense, perfume, and medicine. However, systematic analyses of dynamic changes of secondary metabolites during the process of agarwood formation have not yet been reported. In this study, agarwood was produced by transfusing the agarwood inducer into the trunk of Aquilaria sinensis , and changing patterns of chemical constituents, especially 2-(2-phenylethyl)chromones (PECs), in wood samples collected from the 1st to 12th month, were analyzed by GC-EI-MS and UPLC-ESI-MS/MS methods...
May 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29799160/oxymatrine-exerts-protective-effects-on-osteoarthritis-via-modulating-chondrocyte-homoeostasis-and-suppressing-osteoclastogenesis
#14
Yafei Jiang, Weilin Sang, Cong Wang, Haiming Lu, Tao Zhang, Zhuoying Wang, Yu Liu, Bao Xue, Song Xue, Zhengdong Cai, Yingqi Hua, Libo Zhu, Jinzhong Ma
Osteoarthritis (OA) is a common degenerative disease characterized by the progressive destruction both articular cartilage and the subchondral bone. The agents that can effectively suppress chondrocyte degradation and subchondral bone loss are crucial for the prevention and treatment of OA. Oxymatrine (OMT) is a natural compound with anti-inflammatory and antitumour properties. We found that OMT exhibited a strong inhibitory effect on LPS-induced chondrocyte inflammation and catabolism. To further support our results, fresh human cartilage explants were treated with LPS to establish an ex vivo degradation model, and the results revealed that OMT inhibited the catabolic events of LPS-stimulated human cartilage and substantially attenuated the degradation of articular cartilage ex vivo...
May 25, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29798198/-systematic-review-on-orofacial-myofunctional-therapy-to-treat-obstructive-sleep-apnea-hypopnea-syndrome
#15
REVIEW
L M Wu, X F Wu, Z M Yu, Y Liu
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is an important risk factor for cardiovascular and cerebrovascular diseases. The widespread collapse of the airway, which can't maintain its normal position and structure, is an important cause of OSAHS. Noninvasive ventilator-assisted ventilation is the preferred treatment for OSAHS, but there are shortcomings of poor compliance. Orofacial myofunctional therapy (OMT) is a noninvasive, simple, low-cost, low-risk therapy that is expected to replace noninvasive ventilator-assisted ventilation to a certain extent...
November 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29797622/concomitant-drug-abuse-of-opioid-dependent-patients-in-maintenance-treatment-detected-with-a-multi-target-screening-of-oral-fluid
#16
Elias Wagner, Florian Raabe, Gabriele Martin, Catja Winter, Diana Plörer, Daniela L Krause, Kristina Adorjan, Gabriele Koller, Oliver Pogarell
BACKGROUND AND OBJECTIVES: Numbers of drug-related deaths have been growing in Europe and the USA, especially those attributable to mixed drug consumption. Overdose deaths account for about one third up to one half of all illicit drug deaths worldwide. In most cases opioids are involved. Opioid maintenance treatment (OMT) is a well-established therapy option among people with opioid dependence. The aim of this study was to assess concomitant substance abuse in opioid-dependent patients under OMT in two centers in Munich, Germany...
May 24, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29787734/osteopathic-manipulative-treatment-including-specific-diaphragm-techniques-improves-pain-and-disability-in-chronic-non-specific-low-back-pain-a-randomized-trial
#17
Mireia Martí-Salvador, Laura Hidalgo-Moreno, Julio Doménech-Fernández, Juan Francisco Lisón, Maria Dolores Arguisuelas
OBJECTIVE: To investigate the effects of an osteopathic manipulative treatment (OMT) which includes a diaphragm intervention compared to the same OMT with a sham-diaphragm intervention in chronic non-specific low back pain (NS-CLBP). DESIGN: Parallel group randomized controlled trial SETTING: private and institutional health centers. PARTICIPANTS: Sixty-six subjects (18-60 yrs.) with a diagnosis of NS-CLBP lasting at least 3 months. INTERVENTIONS: Participants were randomized to receive either an OMT protocol including specific diaphragm techniques (n=33) or the same OMT protocol with a sham-diaphragm intervention (n=33), conducted in five sessions provided during 4 weeks...
May 19, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29778671/international-study-of-comparative-health-effectiveness-with-medical-and-invasive-approaches-ischemia-trial-rationale-and-design
#18
David J Maron, Judith S Hochman, Sean M O'Brien, Harmony R Reynolds, William E Boden, Gregg W Stone, Sripal Bangalore, John A Spertus, Daniel B Mark, Karen P Alexander, Leslee Shaw, Jeffrey S Berger, T Bruce Ferguson, David O Williams, Robert A Harrington, Yves Rosenberg
BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative approach with catheterization reserved for failure of medical therapy in patients with moderate or severe ischemia...
April 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29769559/elevated-plasma-lipoprotein-a-levels-were-associated-with-increased-risk-of-cardiovascular-events-in-chinese-patients-with-stable-coronary-artery-disease
#19
Wen Dai, Junke Long, Ying Cheng, Yaqin Chen, Shuiping Zhao
Recent studies have suggested that lipoprotein(a) [Lp(a)] is associated with cardiovascular disease (CVD). However, the contribution of Lp(a) to residual risk of CVD has not been determined in Chinese populations. We conducted a prospective study to evaluate the association between Lp(a) and the risk of major adverse cardiovascular events (MACEs) in patients with stable coronary artery disease (CAD) who received optimal medication treatment (OMT). The study enrolled 1602 patients with stable CAD from 5 hospitals in China...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29754474/oxymatrine-causes-hepatotoxicity-by-promoting-the-phosphorylation-of-jnk-and-induction-of-endoplasmic-reticulum-stress-mediated-by-ros-in-lo2-cells
#20
Li-Li Gu, Zhe-Lun Shen, Yang-Lei Li, Yi-Qi Bao, Hong Lu
Oxymatrine (OMT) often used in treatment for chronic hepatitis B virus infection in clinic. However, OMT-induced liver injury has been reported. In this study, we aim to investigate the possible mechanism of OMT-induced hepatotoxicity in human normal liver cells (L02). Exposed cells to OMT, the cell viability were decreased and apoptosis rate increased, the intracellular markers of oxidative stress were changed. Simultaneously, OMT altered apoptotic related proteins levels, including Bcl-2, Bax and pro-caspase-8/-9/-3...
May 10, 2018: Molecules and Cells
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