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https://www.readbyqxmd.com/read/29681057/camptotheca-acuminata-10-hydroxycamptothecin-o-methyltransferase-an-alkaloid-biosynthetic-enzyme-coopted-from-flavonoid-metabolism
#1
Vonny Salim, A Daniel Jones, Dean DellaPenna
The medicinal plant Camptotheca acuminata accumulates camptothecin, 10-hydroxycamptothecin, and 10-methoxycamptothecin as its major bioactive monoterpene indole alkaloids. Here, we describe identification and functional characterization of 10-hydroxycamptothecin O-methyltransferase (Ca10OMT), a member of the Diverse subclade of Class II OMTs. Ca10OMT is highly active toward both its alkaloid substrate and a wide range of flavonoids in vitro and in this way contrasts with other alkaloid OMTs in the subclade that only utilize alkaloid substrates...
April 22, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29671681/sexual-dysfunctions-are-predicted-by-childhood-sexual-abuse-in-women-with-opioid-use-disorder
#2
Ruken Ağaçhanlı, İzgi Alnıak, Cuneyt Evren
BACKGROUND: Studies on sexual functioning of populations with substance use disorders (SUDs) are mostly conducted with male substance users. We have very limited information about the sexuality and related factors in women with opioid use disorder (OUD). OBJECTIVES: We aimed to evaluate the relationship between childhood traumatic experiences (CTEs) and sexual dysfunctions (SDs) of women with OUD and to compare it with a sample of women who do not have SUD. METHODS: Participants included 51 outpatient women with OUD who were on opioid maintenance treatment (OMT) with Buprenorphine/Naloxone and 48 women without SUD...
April 19, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29668780/the-role-of-oxymatrine-in-regulating-tgf-%C3%AE-1-in-rats-with-hepatic-fibrosis
#3
Jing Wu, Lin Pan, Xueqin Jin, Weihua Li, Hongbing Li, Jianmao Chen, Wen Yang
PURPOSE: To investigate whether oxymatrine (OMT) prevents hepatic fibrosis in rats by regulating liver transforming growth factor β1 (TGF-β1) level. METHODS: Hepatic fibrosis was induced in rats by thioacetamide (TAA). Blood was collected at the end of week 12 to determine the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutathione (GSH). Changes in liver tissue were observed after hematoxylin-eosin (HE) staining. RESULTS: Fibrosis was confirmed by Masson's collagen staining...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668609/the-success-of-opening-single-chronic-total-occlusion-lesions-to-improve-myocardialviabilitytrial-sos-comedy-study-protocol-of-a-prospective-multicenter-study
#4
Rongchong Huang, Xiantao Song, Haishan Zhang, Wen Tian, Zheng Huang, Xingwei Zhang, Junqing Yang, Dongfeng Zhang, Jian Wu, Lei Zhong, Henry H Ting
AIMS: Success of opening single (SOS)-comedy is a prospective multicenter study to compare the improvement in the decrease of myocardial viability by percutaneous coronary intervention (PCI) with that by optimal medical therapy (OMT) alone in patients with chronic total occlusion (CTO) of a single coronary artery. METHODS AND RESULTS: The risks and the benefits of both options (PCI and OMT) were listed in a CTO decision aid (DA). Eligible participants detected by invasive coronary angiography (ICA) or coronary computed tomography angiography (CCTA) were divided into PCI or OMT groups according to patients' choice after shared-decision making process with DA...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29655410/non-orthodontic-intervention-and-non-nutritive-sucking-behaviours-a-literature-review
#5
REVIEW
Liyana Tanny, Boyen Huang, Noel Ye Naung, Geoffrey Currie
Anterior open bite (AOB) is one of the most complex malocclusions to manage. AOB is caused by either by skeletal, genetic or environmental factors. Numerous treatment options are currently utilised to manage AOB. These vary from non-invasive behavioural shaping to orthodontic and surgical interventions. This paper reviews the available orthodontic and non-orthodontic interventions used in the management of AOB. The literature review was carried out using the PubMed search engine from the first of January 2000 to the first of June 2017...
April 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29626742/dissatisfaction-with-opioid-maintenance-treatment-partly-explains-reported-side-effects-of-medications
#6
Ashley Elizabeth Muller, Ronny Bjørnestad, Thomas Clausen
BACKGROUND: Drop-out is a core problem in opioid maintenance treatment (OMT), but patients' reactions to and acceptance of the various OMT medications are insufficiently investigated. In Norway, there has been vocal patient resistance to the newest medication, buprenorphine-naloxone (BNX), and complaints have focused on the side effect profile. There has been no comparison of patient satisfaction and side effects of the three most common OMT medications. AIM: To compare patient satisfaction with OMT and side effects of BNX, buprenorphine monopreparate (BUP), and methadone (MET) as reported by patients...
March 29, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29605686/long-term-clinical-outcomes-of-optimal-medical-therapy-vs-successful-percutaneous-coronary-intervention-for-patients-with-coronary-chronic-total-occlusions
#7
Lei Guo, Lei Zhong, Kun Chen, Jian Wu, Rong-Chong Huang
OBJECTIVES: There are little data on the long-term clinical outcomes of optimal medical therapy (OMT) compared with successful percutaneous coronary intervention (PCI) in patients with chronic total occlusions (CTOs). METHODS: A total of 388 patients with ≥1 CTO were enrolled from January 2008 to December 2010. 62 patients were excluded, and 326 patients were divided into an OMT group (n = 125) and PCI group (n = 201) according to the initial treatment strategy...
March 29, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29582060/resident-and-faculty-attitudes-toward-osteopathic-focused-education
#8
Laura K Hempstead, Beth Rosemergey, Steven Foote, Kelly Swade, Karen B Williams
Context: The transition period for the single accreditation system for graduate medical education under the Accreditation Council for Graduate Medical Education (ACGME) began on July 1, 2015, and will end June 30, 2020. As of February 5, 2018, 82.6% of residency programs accredited by the American Osteopathic Association (AOA) have applied for or achieved ACGME accreditation and 160 programs have applied for or achieved osteopathic recognition. Objective: To assess baseline attitudes of osteopathic and allopathic faculty and residents in AOA-accredited and dually accredited residency programs regarding the value of osteopathic-focused educational curricula and mentors...
April 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29573897/documenting-combined-congenital-upper-limb-anomalies-using-the-oberg-manske-and-tonkin-classification-implications-for-epidemiological-research-and-outcome-comparisons
#9
Martijn Baas, Pieter R Zwanenburg, Steven E R Hovius, Christianne A van Nieuwenhoven
PURPOSE: Congenital upper limb anomalies (CULAs) exhibit a wide spectrum of phenotypic manifestations. To help the clinician evaluating this variety of CULAs, the Oberg, Manske, and Tonkin (OMT) classification was recently introduced. The OMT classification allows for documentation of combined hand anomalies. However, subsequent epidemiological and validation studies using the OMT scheme commonly registered only the main anomaly per arm. This study illustrates both the deficits of single diagnosis documentation as well as the merits of registering every anomaly for epidemiological research, outcome comparison, and overall applicability of the classification...
March 21, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29570670/oxymatrine-inhibits-influenza-a-virus-replication-and-inflammation-via-tlr4-p38-mapk-and-nf-%C3%AE%C2%BAb-pathways
#10
Jian-Ping Dai, Qian-Wen Wang, Yun Su, Li-Ming Gu, Hui-Xiong Deng, Xiao-Xuan Chen, Wei-Zhong Li, Kang-Sheng Li
Oxymatrine (OMT) is a strong immunosuppressive agent that has been used in the clinic for many years. In the present study, by using plaque inhibition, luciferase reporter plasmids, qRT-PCR, western blotting, and ELISA assays, we have investigated the effect and mechanism of OMT on influenza A virus (IAV) replication and IAV-induced inflammation in vitro and in vivo. The results showed that OMT had excellent anti-IAV activity on eight IAV strains in vitro. OMT could significantly decrease the promoter activity of TLR3, TLR4, TLR7, MyD88, and TRAF6 genes, inhibit IAV-induced activations of Akt, ERK1/2, p38 MAPK, and NF-κB pathways, and suppress the expressions of inflammatory cytokines and MMP-2/-9...
March 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29527487/hypersynchrony-in-meg-spectral-amplitude-in-prospectively-identified-6-month-old-infants-prenatally-exposed-to-alcohol
#11
Julia M Stephen, Lucinda Flynn, Danielle Kabella, Megan Schendel, Sandra Cano, Daniel D Savage, William Rayburn, Lawrence M Leeman, Jean Lowe, Ludmila N Bakhireva
Early identification of children who experience developmental delays due to prenatal alcohol exposure (PAE) remains a challenge for individuals who do not exhibit facial dysmorphia. It is well-established that children with PAE may still exhibit the cognitive and behavioral difficulties, and individuals without facial dysmorphia make up the majority of individuals affected by PAE. This study employed a prospective cohort design to capture alcohol consumption patterns during pregnancy and then followed the infants to 6 months of age...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29526865/oxymatrine-attenuates-lipopolysaccharide-induced-acute-lung-injury-by-activating-the-epithelial-sodium-channel-and-suppressing-the-jnk-signaling-pathway
#12
Bingji Jin, Hong Jin
The epithelial sodium channel (ENaC) and mitogen-activated protein kinase (MAPK) pathway have been reported to be associated with the progression of acute lung injury (ALI). Oxymatrine (OMT) alone or combined with other drugs can ameliorate paraquat- or oleic acid-induced lung injury. However, the effect of OMT on lipopolysaccharide (LPS)-induced ALI remains unknown. The aim of the present study was to evaluate whether OMT can attenuate LPS-induced ALI through regulation of the ENaC and MAPK pathway using an ALI mouse model...
March 9, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29525634/performance-of-the-oraquick-hepatitis-c-virus-antibody-test-in-oral-fluid-and-fingerstick-blood-before-and-after-treatment-induced-viral-clearance
#13
Carmina Pallarés, Ângela Carvalho-Gomes, Vanessa Hontangas, Isabel Conde, Tomasso Di Maira, Victoria Aguilera, Salvador Benlloch, Marina Berenguer, F Xavier López-Labrador
BACKGROUND: A reliable population screening strategy for hepatitis C virus (HCV) infection may be based in easy-to-use point-of-care (POC) tests for HCV antibodies, but validation data is needed before their potential widespread use in primary care or outreach practice. Besides, the sensitivity of these POC tests in patients with spontaneous or treatment-induced viral clearance is unknown. OBJECTIVES: To test the performance of a non-invasive POC anti-HCV test (OraQuick HCV rapid test) in oral mucosal transudate (OMT) and fingerstick blood from patients with known anti-HCV serostatus and with or without active viremia (after treatment-induced clearance)...
February 24, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29521311/serial-assessment-of-endothelial-vasomotor-function-using-optimal-medical-therapy-predicts-clinical-outcomes-in-patients-after-complete-coronary-revascularization
#14
Masahide Tokue, Raisuke Iijima, Masao Moroi, Masato Nakamura
OBJECTIVE: Previous studies have demonstrated the importance of intensive optimal medical therapy (OMT) in patients with coronary artery disease (CAD). To investigate our hypothesis that patients with and without OMT achievement differed with respect to the risk of future cardiac events, we investigated the endothelial function in patients with CAD who underwent percutaneous coronary intervention (PCI) and contemporary medical therapy. METHODS: We conducted a prospective longitudinal cohort study to evaluate the endothelial function in 96 consecutive patients at 12 h after admission and 3 months at <12 h after admission and at 3 months after discharge by measuring the brachial artery dilatation after 5 min of forearm ischemia flow-mediated dilation (FMD)...
March 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29510402/oxymatrine-inhibits-homocysteine-mediated-autophagy-via-mif-mtor-signaling-in-human-umbilical-vein-endothelial-cells
#15
Yanyan Zhang, Yuan Zhang, Jiayu Tang, Shuang Zhao, Chen Li, Yong-Pan Huang, Minhan Yi
BACKGROUND/AIMS: Genetic or nutritional deficiencies in homocysteine (Hcy)metabolism lead to the accumulation of Hcy and its metabolites in the blood. This can lead to hyperhomocysteinemia (HHcy), which is an independent risk factor for cardiovascular disease. Studies have shown that HHcy leads to endothelial dysfunction, a hallmark of atherosclerosis, which may explain this link. The precise mechanism remains unclear, but a strong possibility is excessive HHCy-induced autophagy. Autophagy has been better studied in ischemia/reperfusion (I/R) injuries, and previous work showed that Oxymatrine (OMT), a quinolizidine alkaloid, protects cells against myocardial I/R injury by inhibiting autophagy...
February 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29504606/ctd-2020k17-1-a-novel-long-non-coding-rna-promotes-migration-invasion-and-proliferation-of-serous-ovarian-cancer-cells-in-vitro
#16
Linfei Zhu, Qixuan Guo, Xinxin Lu, Junhua Zhao, Jinxin Shi, Zhenning Wang, Xin Zhou
BACKGROUND Ovarian cancer is the most lethal malignant tumor of the female reproductive system, and the metastasis is one of the major factors that contribute to the poor outcome of patients with OC. Accumulating evidence indicates that lncRNAs are expressed and play important regulatory roles in ovarian cancer. MATERIAL AND METHODS Aberrant lncRNAs in primary ovarian cancer tissues (POCTs) and paired omental metastasis tissues (OMTs) of patients with HGSOC were studied via lncRNA microarray. Real-time PCR was performed to examine CTD-2020K17...
March 5, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29480923/omt-for-patients-with-sacral-somatic-dysfunction
#17
Katherine Yu, Kim Pfotenhauer, Stacey Pierce-Talsma
No abstract text is available yet for this article.
March 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29480916/ultrasonographic-evaluation-of-the-effect-of-osteopathic-manipulative-treatment-on-sacral-base-asymmetry
#18
Karen T Snider, Crystal L Redman, Christopher R Edwards, Shalini Bhatia, Tatyana Kondrashova
Context: Patients with low back pain (LBP) may receive osteopathic manipulative treatment (OMT) to resolve or manage their pain. The indication for OMT for patients with LBP is the presence of somatic dysfunction, diagnosed using palpatory examination. Because palpatory findings commonly have poor interexaminer reliability, the current study used ultrasonography (US) to establish pre-OMT and post-OMT musculoskeletal measurements of relative asymmetry between pelvic and sacral bony landmarks...
March 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29480914/characterizing-adverse-events-reported-immediately-after-osteopathic-manipulative-treatment
#19
Brian F Degenhardt, Jane C Johnson, William J Brooks, Lisa Norman
Context: Although adverse events in various types of manual therapy have been previously investigated, little is known about the incidence and types of adverse events that occur after osteopathic manipulative treatment (OMT). Objective: To estimate the incidence and characterize the types of adverse events that patients report after OMT and prior to leaving the office to increase the likelihood of identifying adverse events caused by OMT. Methods: As part of a prospective study evaluating the use and effectiveness of OMT, patients assessed how they felt immediately after OMT compared with before OMT using a 5-point ordinal rating scale (much better, better, about the same, worse, much worse)...
March 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29480912/the-safety-of-osteopathic-manipulative-treatment-omt
#20
Michael A Seffinger
No abstract text is available yet for this article.
March 1, 2018: Journal of the American Osteopathic Association
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