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https://www.readbyqxmd.com/read/29227540/human-t-lymphotropic-virus-1-htlv-1-pathogenesis-a-systems-virology-study
#1
Sayed-Hamidreza Mozhgani, Mohadeseh Zarei Ghobadi, Majid Teymoori-Rad, Talat Mokhtari Azad, Mehdi Mirzaie, Mohsen Sheikhi, Seyed Mohammad Jazayeri, Ramin Shabahrami, Hedayatollah Ghourchian, Mohieddin Jafari, Seyed Abdolrahim Rezaee, Mehdi Norouzi
The main mechanisms of interaction between Human T-lymphotropic virus type 1 (HTLV-1) and its hosts in manifestation of related diseases including HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and Adult T-cell leukemia/lymphoma (ATLL) are yet to be determined. It is pivotal to find out the changes in the genes expression toward an asymptomatic or symptomatic states. To this end, the systems virology analysis was performed. Firstly, the differentially expressed genes (DEGs) were taken pairwise among the four sample sets of Normal, Asymptomatic Carriers (ACs), ATLL, and HAM/TSP...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29221181/analysis-of-ctcl-cell-lines-reveals-important-differences-between-mycosis-fungoides-s%C3%A3-zary-syndrome-vs-htlv-1-leukemic-cell-lines
#2
Elena Netchiporouk, Jennifer Gantchev, Matthew Tsang, Philippe Thibault, Andrew K Watters, John-Douglas Matthew Hughes, Feras M Ghazawi, Anders Woetmann, Niels Ødum, Denis Sasseville, Ivan V Litvinov
HTLV-1 is estimated to affect ~20 million people worldwide and in ~5% of carriers it produces Adult T-Cell Leukemia/Lymphoma (ATLL), which can often masquerade and present with classic erythematous pruritic patches and plaques that are typically seen in Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most recognized variants of Cutaneous T-Cell Lymphomas (CTCL). For many years the role of HTLV-1 in the pathogenesis of MF/SS has been hotly debated. In this study we analyzed CTCL vs. HTLV-1+ leukemic cells...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29216835/human-t-lymphotropic-virus-1aa-circulation-and-risk-factors-for-sexually-transmitted-infections-in-an-amazon-geographic-area-with-lowest-human-development-index-maraj%C3%A3-island-northern-brazil
#3
Samantha Assis de Aguiar, Samires Avelino de Souza França, Barbara Brasil Santana, Mike Barbosa Santos, Felipe Bonfim Freitas, Glenda Ferreira, Izaura Cayres-Vallinoto, Marluísa O G Ishak, Ricardo Ishak, Antonio Carlos Rosário Vallinoto
BACKGROUND: This cross-sectional study evaluated the prevalence of infection with human T-lymphotropic virus 1 and 2 (HTLV-1 and HTLV-2) in a population from the municipalities of Anajás, Chaves, São Sebastião da Boa Vista (SSBV) and Portel in the Marajó Archipelago and correlated these data with the epidemiological characteristics of the study population. METHODS: A total of 1899 biological samples were evaluated. The samples were screened for the presence of anti-HTLV antibodies using an enzyme-linked immunosorbent assay (ELISA), and infection was confirmed using conventional polymerase chain reaction (PCR), real-time PCR and nucleotide sequencing...
December 8, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29212930/control-of-htlv-1-infection-by-eliminating-envelope-protein-positive-cells-with-recombinant-vesicular-stomatitis-viruses-encoding-htlv-1-primary-receptor
#4
Kenta Tezuka, Kazu Okuma, Madoka Kuramitsu, Sahoko Matsuoka, Reiko Tanaka, Yuetsu Tanaka, Isao Hamaguchi
Human T-cell leukemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia (ATL), which is frequently resistant to current available therapies and has a very poor prognosis. To prevent the development of ATL among carriers it is important to control HTLV-1-infected cells in infected individuals. Therefore, the establishment of novel therapies with drugs specifically targeting infected cells is urgently required. This study aimed to develop a potential therapy by generating recombinant vesicular stomatitis viruses (rVSVs) that lack an envelope glycoprotein G and instead encode HTLV-1 receptor(s) with human glucose transporter 1 (GLUT1), neuropilin 1 (NRP1), or heparan sulfate proteoglycans (HSPGs) including syndecan 1 (SDC1), designated as VSVΔG-GL, VSVΔG-NP, or VSVΔG-SD, respectively...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29202792/the-cc-chemokine-ligand-ccl-1-upregulated-by-the-viral-transactivator-tax-can-be-downregulated-by-minocycline-possible-implications-for-long-term-treatment-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis
#5
Mineki Saito, Hiroe Sejima, Tadasuke Naito, Hiroshi Ushirogawa, Toshio Matsuzaki, Eiji Matsuura, Yuetsu Tanaka, Tatsufumi Nakamura, Hiroshi Takashima
BACKGROUND: Chemokine (C-C motif) ligand 1 (CCL1) is produced by activated monocytes/ macrophages and T-lymphocytes, and acts as a potent attractant for Th2 cells and a subset of T-regulatory (Treg) cells. Previous reports have indicated that CCL1 is overexpressed in adult T-cell leukemia cells, mediating an autocrine anti-apoptotic loop. Because CCL1 is also known as a potent chemoattractant that plays a major role in inflammatory processes, we investigated the role of CCL1 in the pathogenesis of human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...
December 4, 2017: Virology Journal
https://www.readbyqxmd.com/read/29186194/human-t-cell-leukemia-virus-type-1-infects-multiple-lineage-hematopoietic-cells-in-vivo
#6
Rie Furuta, Jun-Ichirou Yasunaga, Michi Miura, Kenji Sugata, Akatsuki Saito, Hirofumi Akari, Takaharu Ueno, Norihiro Takenouchi, Jun-Ichi Fujisawa, Ki-Ryang Koh, Yusuke Higuchi, Mohamed Mahgoub, Masakazu Shimizu, Fumihiko Matsuda, Anat Melamed, Charles R Bangham, Masao Matsuoka
Human T-cell leukemia virus type 1 (HTLV-1) infects mainly CD4+CCR4+ effector/memory T cells in vivo. However, it remains unknown whether HTLV-1 preferentially infects these T cells or this virus converts infected precursor cells to specialized T cells. Expression of viral genes in vivo is critical to study viral replication and proliferation of infected cells. Therefore, we first analyzed viral gene expression in non-human primates naturally infected with simian T-cell leukemia virus type 1 (STLV-1), whose virological attributes closely resemble those of HTLV-1...
November 29, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29186062/viral-oncology-molecular-biology-and-pathogenesis
#7
REVIEW
Uyen Ngoc Mui, Christopher T Haley, Stephen K Tyring
Oncoviruses are implicated in approximately 12% of all human cancers. A large number of the world's population harbors at least one of these oncoviruses, but only a small proportion of these individuals go on to develop cancer. The interplay between host and viral factors is a complex process that works together to create a microenvironment conducive to oncogenesis. In this review, the molecular biology and oncogenic pathways of established human oncoviruses will be discussed. Currently, there are seven recognized human oncoviruses, which include Epstein-Barr Virus (EBV), Human Papillomavirus (HPV), Hepatitis B and C viruses (HBV and HCV), Human T-cell lymphotropic virus-1 (HTLV-1), Human Herpesvirus-8 (HHV-8), and Merkel Cell Polyomavirus (MCPyV)...
November 29, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29168728/interference-of-htlv-1-tax-protein-with-cell-polarity-regulators-defining-the-subcellular-localization-of-the-tax-dlg1-interaction
#8
Federico Marziali, Marina Bugnon Valdano, Clarisse Brunet Avalos, Lucía Moriena, Ana Laura Cavatorta, Daniela Gardiol
Human T cell leukemia virus (HTLV)-1 Tax (Tax) protein is very important in viral replication and cell transformation. Tax localizes in the nucleus and cytoplasm in association with organelles. Some activities of Tax depend on interactions with PDZ (PSD-95/Discs Large/Z0-1) domain-containing proteins such as Discs large protein 1 (DLG1) which is involved in cell polarity and proliferation. The DLG1 interaction results in a cytoplasmic co-localization pattern resembling vesicular aggregates, the nature of which is still unknown...
November 23, 2017: Viruses
https://www.readbyqxmd.com/read/29149590/just-a-spoonful-of-sugar-htlv-1-style
#9
Naomi Taylor
Host cell metabolism regulates viral infection. In this issue of Cell Chemical Biology, Kulkarni et al. (2017) reveal the importance of oxygen concentrations and glycolysis in the reactivation of human T cell leukemia virus (HTLV-1). Identifying the host metabolic networks that regulate infection will foster our understanding of HTLV-1-associated pathologies.
November 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29147956/endogenous-sex-hormones-and-memory-performance-in-middle-aged-greek-women-with-subjective-memory-complaints
#10
Eleni Armeni, Michail Apostolakis, Foteini Christidi, Demetrios Rizos, George Kaparos, Konstantinos Panoulis, Areti Augoulea, Andreas Alexandrou, Evangelia Karopoulou, Ioannis Zalonis, Nikolaos Triantafyllou, Irene Lambrinoudaki
The changing hormonal milieu during the menopausal transition may contribute to the development of memory disorders. We aimed to assess the association of sex hormones with memory function in a sample of Greek middle-aged women. This pilot study included 44 women with subjective memory complaints. Memory performance was evaluated using the Hopkins Verbal Learning Test (HVLT), the Brief Visuospatial Memory test (BVMT), and the verbal digits backwards test (VSPAN), to assess verbal, visuospatial, and working memory performance, respectively...
November 16, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29147642/recurrent-cystoisospora-belli-in-a-patient-with-htlv-1-infection
#11
Mustafa Hasan, Eliahu Bishburg, Sandhya Nagarakanti
No abstract text is available yet for this article.
2017: IDCases
https://www.readbyqxmd.com/read/29147486/a-novel-medium-throughput-biological-assay-system-for-htlv-1-infectivity-and-drug-discovery
#12
Mojtaba Fattahi Abdizadeh, Manoochehr Makvandi, Alireza Samarbafzadeh, Kayhan Azadmanesh
Objectives: Here, a reporter cell line containing two reporter vectors were developed, in order to monitor the Human T-Lymphotropic Virus type1(HTLV-1) infectivity and the cell viability simultaneously. Materials and Methods: The reporter cell line was constructed by stably transfected baby hamster's kidney cell line (BHK-21), with the genomes expressing two different reporters in separate plasmids. The first reporter gene is transactivated by the HTLV-1 tax protein, while the second reporter is continuously expressed when introduced into a mammalian cell...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29144838/human-t-cell-leukemia-virus-type-1-persistence-and-pathogenesis
#13
Charles R M Bangham
Human T cell leukemia virus type 1 (HTLV-1), also known as human T lymphotropic virus type 1, was the first exogenous human retrovirus discovered. Unlike the distantly related lentivirus HIV-1, HTLV-1 causes disease in only 5-10% of infected people, depending on their ethnic origin. But whereas HIV-1 infection and the consequent diseases can be efficiently contained in most cases by antiretroviral drug treatment, there is no satisfactory treatment for the malignant or inflammatory diseases caused by HTLV-1...
November 16, 2017: Annual Review of Immunology
https://www.readbyqxmd.com/read/29129607/polymorphisms-in-hla-c-and-kir-alleles-are-not-associated-with-ham-tsp-risk-in-htlv-1-infected-subjects
#14
Tatiane Assone, Fernanda M Malta, Sonia Bakkour, Leilani Montalvo, Arthur M Paiva, Jerusa Smid, Augusto César Penalva de Oliveira, Fernanda de Toledo Gonçalves, Olinda do Carmo Luiz, Luiz Augusto M Fonseca, Philip J Norris, Jorge Casseb
INTRODUCTION: Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association of immune related genetic polymorphisms with viral and immunological markers. METHODS: 247 HTLV-1-infected volunteers, drawn from a larger group of HTLV-infected subjects followed at the Institute of Infectious Diseases "Emilio Ribas" (IIER) for up to 19 years, participated in this study, which ran from June 2011 to July 2016...
November 10, 2017: Virus Research
https://www.readbyqxmd.com/read/29099045/gene-editing-in-human-lymphoid-cells-role-for-donor-dna-type-of-genomic-nuclease-and-cell-selection-method
#15
Anastasia Zotova, Elena Lopatukhina, Alexander Filatov, Musa Khaitov, Dmitriy Mazurov
Programmable endonucleases introduce DNA breaks at specific sites, which are repaired by non-homologous end joining (NHEJ) or homology recombination (HDR). Genome editing in human lymphoid cells is challenging as these difficult-to-transfect cells may also inefficiently repair DNA by HDR. Here, we estimated efficiencies and dynamics of knockout (KO) and knockin (KI) generation in human T and B cell lines depending on repair template, target loci and types of genomic endonucleases. Using zinc finger nuclease (ZFN), we have engineered Jurkat and CEM cells with the 8...
November 2, 2017: Viruses
https://www.readbyqxmd.com/read/29096657/epidemiology-and-genetic-diversity-of-bovine-leukemia-virus
#16
REVIEW
Meripet Polat, Shin-Nosuke Takeshima, Yoko Aida
Bovine leukemia virus (BLV), an oncogenic member of the Deltaretrovirus genus, is closely related to human T-cell leukemia virus (HTLV-I and II). BLV infects cattle worldwide and causes important economic losses. In this review, we provide a summary of available information about commonly used diagnostic approaches for the detection of BLV infection, including both serological and viral genome-based methods. We also outline genotyping methods used for the phylogenetic analysis of BLV, including PCR restriction length polymorphism and modern DNA sequencing-based methods...
November 2, 2017: Virology Journal
https://www.readbyqxmd.com/read/29095831/ct-chest-and-pulmonary-functional-changes-in-patients-with-htlv-associated-myelopathy-in-the-eastern-brazilian-amazon
#17
Luiz Fábio Magno Falcão, Aline Semblano Carreira Falcão, Rita Catarina Medeiros Sousa, Waldônio de Brito Vieira, Robson Tadachi Moraes de Oliveira, Valéria Marques Ferreira Normando, George Alberto da Silva Dias, Marcio Clementino de Souza Santos, Rodrigo Santiago Barbosa Rocha, Gilberto Toshimitsu Yoshikawa, Roberta Vilela Lopes Koyama, Satomi Fujihara, Víctor Augusto Cavaleiro Corrêa, Hellen Thais Fuzii, Juarez Aantônio Simões Quaresma
The aim of this study was to compare computed tomography (CT) scans of chest and lung function among patients with Human T-Lymphotropic Virus Type 1 (HTLV) with and without HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this cross-sectional study performed between January 2013 and June 2016, we included 48 patients with HAM/TSP (19 women and 11 men) and without HAM/TSP (12 women and 6 men). We compared CT findings and lung functions of these groups. Patients who had HAM/TSP had abnormal CT findings (P = 0...
2017: PloS One
https://www.readbyqxmd.com/read/29094771/indolent-waxing-and-waning-cutaneous-presentation-of-htlv-1-associated-adult-t-cell-leukemia-lymphoma-in-an-hiv-1-positive-patient
#18
Justin D Richey, Benjamin J Chen, April C Deng
It is well known that patients infected with human immunodeficiency virus type I (HIV-1) are more likely to develop malignancies such as Kaposi sarcoma, non-Hodgkin lymphoma, and anal and cervical carcinomas.
November 2, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29090417/long-term-clinical-remission-maintained-after-cessation-of-zidovudine-and-interferon-%C3%AE-therapy-in-chronic-adult-t-cell-leukemia-lymphoma
#19
Lucy B Cook, Aileen G Rowan, Maria A Demontis, Sophie Sagawe, Nicolas A Gillet, Anat Melamed, Claire Greiller, Aviva Witkover, Charles R M Bangham, Graham P Taylor
Globally, > 5-10 million people are estimated to be infected with Human T-lymphotropic virus type 1 (HTLV-1), of whom ~ 5% develop adult T-cell leukemia/lymphoma (ATL). Despite advances in chemotherapy, overall survival (OS) has not improved in the 35 years since HTLV-1 was first described. In Europe/USA, combination treatment with zidovudine and interferon-α (ZDV/IFN-α) has substantially changed the management of patients with the leukemic subtypes of ATL (acute or unfavorable chronic ATL) and is under clinical trial evaluation in Japan...
October 31, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29090234/altered-expression-of-cell-cycle-regulators-in-adult-t-cell-leukemia-lymphoma-patients
#20
Reza Torshizi, Ehsan Ghayour Karimani, Kobra Etminani, Mohammad Mehdi Akbarin, Khadijeh Jamialahmadi, Abbas Shirdel, Hossein Rahimi, Abolghasem Allahyari, Amin Golabpour, Houshang Rafatpanah
BACKGROUND: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and compare the HTLV-1 proviral load and the gene expression levels of cyclin-dependent kinase-2 (CDK2), CDK4, p53, and retinoblastoma (Rb) in ATLL and carrier groups...
October 2017: Reports of Biochemistry & Molecular Biology
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