keyword
MENU ▼
Read by QxMD icon Read
search

Htlv

keyword
https://www.readbyqxmd.com/read/29451478/-htlv-1-and-dendritic-cells-a-relation-ship-in-search-of-maturation
#1
Nicolas Futsch, Renaud Mahieux, Hélène Dutartre
No abstract text is available yet for this article.
February 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29444188/switching-and-loss-of-cellular-cytokine-producing-capacity-characterize-in-vivo-viral-infection-and-malignant-transformation-in-human-t-lymphotropic-virus-type-1-infection
#2
Huseini Kagdi, Maria Antonietta Demontis, Juan Carlos Ramos, Graham P Taylor
Adult T-cell leukaemia/lymphoma (ATL) arises from chronic non-malignant human T lymphotropic virus type-1 (HTLV-1) infection which is characterized by high plasma pro-inflammatory cytokines whereas ATL is characterized by high plasma anti-inflammatory (IL-10) concentrations. The poor prognosis of ATL is partly ascribed to disease-associated immune suppression. ATL cells have a CD4+CCR4+CD26-CD7- immunophenotype but infected cells with this immunophenotype ('ATL-like' cells) are also present in non-malignant HTLV-1 infection...
February 14, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29441057/stability-of-the-htlv-1-antisense-derived-protein-hbz-is-regulated-by-the-e3-ubiquitin-protein-ligase-ubr5
#3
Amanda R Panfil, Jacob Al-Saleem, Cory M Howard, Nikoloz Shkriabai, Mamuka Kvaratskhelia, Patrick L Green
Human T-cell leukemia virus type 1 (HTLV-1) encodes a protein derived from the antisense strand of the proviral genome designated HBZ (HTLV-1 basic leucine zipper factor). HBZ is the only viral gene consistently expressed in infected patients and adult T-cell leukemia/lymphoma (ATL) tumor cell lines. It functions to antagonize many activities of the Tax viral transcriptional activator, suppresses apoptosis, and supports proliferation of ATL cells. Factors that regulate the stability of HBZ are thus important to the pathophysiology of ATL development...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29423617/human-t-cell-lymphotropic-virus-htlv-associated-encephalopathy-an-under-recognised-cause-of-acute-encephalitis-case-series-and-literature-review
#4
Ania A Crawshaw, Divya Dhasmana, Brynmor Jones, Carolyn M Gabriel, Steve Sturman, Nicholas W S Davies, Graham P Taylor
Human T-cell lymphotropic virus (HTLV)-1-associated myelopathy (HAM) is well described. Clinical features are predominantly consistent with cord pathology, though imaging and autopsy studies also demonstrate brain inflammation. In general, this is subclinical; however, six cases have previously been reported of encephalopathy in HTLV-1-infected patients, without alternative identified aetiology. We describe three further cases of encephalitis in the UK HAM cohort (n = 142), whereas the annual incidence of acute encephalitis in the general population is 0...
February 8, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29421321/2017-international-meeting-of-the-global-virus-network
#5
REVIEW
Mike Catton, Glenda Gray, Diane Griffin, Hideki Hasegawa, Stephen Kent, Jason Mackenzie, Edward McSweegan, Natalia Mercer, Linfa Wang
The Global Virus Network (GVN) was established in 2011 to strengthen research and responses to emerging viral causes of human disease and to prepare against new viral pandemics. There are now 40 GVN Centers of Excellence and 6 Affiliate laboratories in 24 countries. The 2017 meeting was held from September 25-27 in Melbourne, Australia, and was hosted by the Peter Doherty Institute for Infection and Immunity and the Institut Pasteur. This report highlights the recent accomplishments of GVN researchers in several important areas of medical virology, including the recent Zika epidemic, infections by human papillomavirus, influenza, HIV, hepatitis C, HTLV-1, and chikungunya viruses, and new and emerging viruses in the Australasia region...
February 5, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29419731/inflammatory-alteration-of-human-t-cells-exposed-continuously-to-asbestos
#6
REVIEW
Naoko Kumagai-Takei, Shoko Yamamoto, Suni Lee, Megumi Maeda, Hidenori Masuzzaki, Nagisa Sada, Min Yu, Kei Yoshitome, Yasumitsu Nishimura, Takemi Otsuki
Asbestos is a known carcinogen and exposure can lead to lung cancer and malignant mesothelioma. To examine the effects of asbestos fibers on human immune cells, the human T cell leukemia/lymphoma virus (HTLV)-1 immortalized human T cell line MT-2 was employed. Following continuous exposure to asbestos fibers for more than eight months, MT-2 sublines showed acquisition of resistance to asbestos-induced apoptosis with decreased death signals and increased surviving signals. These sublines showed various characteristics that suggested a reduction in anti-tumor immunity...
February 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29414279/mogamulizumab-anti-ccr4-in-htlv-1-associated-myelopathy
#7
Tomoo Sato, Ariella L G Coler-Reilly, Naoko Yagishita, Natsumi Araya, Eisuke Inoue, Rie Furuta, Toshiki Watanabe, Kaoru Uchimaru, Masao Matsuoka, Naoki Matsumoto, Yasuhiro Hasegawa, Yoshihisa Yamano
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) causes the debilitating neuroinflammatory disease HTLV-1-associated myelopathy-tropical spastic paraparesis (HAM-TSP) as well as adult T-cell leukemia-lymphoma (ATLL). In patients with HAM-TSP, HTLV-1 infects mainly CCR4+ T cells and induces functional changes, ultimately causing chronic spinal cord inflammation. We evaluated mogamulizumab, a humanized anti-CCR4 monoclonal antibody that targets infected cells, in patients with HAM-TSP...
February 8, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29411267/a-review-of-new-findings-in-adult-t-cell-leukemia-lymphoma-a-focus-on-current-and-emerging-treatment-strategies
#8
REVIEW
Olivier Hermine, Juan Carlos Ramos, Kensei Tobinai
Adult T-cell leukemia-lymphoma (ATL), a rare and aggressive T-cell malignancy caused by human T-cell lymphotropic virus type 1 (HTLV-1), is associated with a poor prognosis. Evidence-based standard treatment options are lacking and outcomes are generally unsatisfactory, particularly for patients with relapsed or refractory disease. Continued research is contributing to changing treatment landscape as a number of existing and investigational agents are evaluated. We describe the epidemiology of HTLV-1 and ATL, discuss the biology behind the disease, review current treatment practices and guidelines, and provide an overview of emerging therapies in ATL, with a focus on those for relapsed or refractory disease...
February 6, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29400072/role-of-integrin-signaling-activation-on-the-development-of-human-t-cell-leukemia-virus-1-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-its-relationship-to-htlv-1-infected-cd4-t-cell-transmigrating-activity-into-the-tissues
#9
Tatsufumi Nakamura, Katsuya Satoh, Hideki Nakamura, Naomi Fukushima, Yoshihiro Nishiura, Takafumi Furuya, Katsuhiro Ichinose
The main clinical feature of human T-cell leukemia virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is slowly progressive spastic paraparesis with bladder dysfunction. HAM/TSP is induced by chronic inflammation in the spinal cord, mainly the lower thoracic cord. A long-standing bystander mechanism, such as the destruction of surrounding tissues by the interaction between infiltrated Th1-like, HTLV-1-infected CD4+ T cells and HTLV-1-specific CD8+ cytotoxic T cells (CTL), is probably critical for the induction of chronic inflammation...
February 5, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29388862/hla-g-gene-polymorphism-in-egyptian-patients-with-non-hodgkin-lymphoma-and-its-clinical-outcome
#10
Gehan Abd-Elfatah Tawfeek, Suzan Alhassanin
BACKGROUND: Non-Hodgkin lymphoma (NHL) is a major cancer in Egypt and worldwide and has many risk factors including genes involved in the immune response. AIM: we investigated the HLA-G 14bp gene polymorphism as a risk factor for NHL and its clinic pathologic features. The study involved 150 patients with NHL and 100 healthy control. Full histories, clinical examination, C.T scan and laboratory investigations such as CBC, LDH, ?2microglobulin and HCV RNA by qualitative real time PCR were performed for all subjects...
February 1, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29384908/anemia-intractable-vomiting-chronic-diarrhea-and-syndrome-of-inappropriate-antidiuretic-secretion-a-diagnostic-dilemma-disseminated-strongyloidosis-in-a-patient-with-newly-diagnosed-htlv-infection-case-report-and-review-of-literature
#11
Hassan Tariq, Muhammad Umar Kamal, Pavithra Reddy, Bharat Bajantri, Masooma Niazi, Ajsza Matela, Cosmina Zeana, Ariyo Ihimoyan, Anil Dev, Sridhar Chilimuri
RATIONALE: Strongyloidiasis hyperinfection and disseminated disease have high mortality rates due to several complications and early detection of Strongyloides infection is therefore prudent. PATIENT CONCERNS: A 37-year-old male patient came with chronic diarrhea, intractable vomiting and was found to have hyponatremia, and anemia on the initial laboratory tests. DIAGNOSES: Further work up revealed syndrome of inappropriate antidiuretic secretion to be the cause of the hyponatremia in addition to gastrointestinal loses...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29382845/htlv-1-tax-plugs-and-freezes-upf1-helicase-leading-to-nonsense-mediated-mrna-decay-inhibition
#12
Francesca Fiorini, Jean-Philippe Robin, Joanne Kanaan, Malgorzata Borowiak, Vincent Croquette, Hervé Le Hir, Pierre Jalinot, Vincent Mocquet
Up-Frameshift Suppressor 1 Homolog (UPF1) is a key factor for nonsense-mediated mRNA decay (NMD), a cellular process that can actively degrade mRNAs. Here, we study NMD inhibition during infection by human T-cell lymphotropic virus type I (HTLV-1) and characterise the influence of the retroviral Tax factor on UPF1 activity. Tax interacts with the central helicase core domain of UPF1 and might plug the RNA channel of UPF1, reducing its affinity for nucleic acids. Furthermore, using a single-molecule approach, we show that the sequential interaction of Tax with a RNA-bound UPF1 freezes UPF1: this latter is less sensitive to the presence of ATP and shows translocation defects, highlighting the importance of this feature for NMD...
January 30, 2018: Nature Communications
https://www.readbyqxmd.com/read/29380451/human-t-lymphotropic-virus-type-1-infection-and-solid-organ-transplantation
#13
REVIEW
Graham P Taylor
HTLV infection appears to be more common among renal transplant candidates than in the related general population. HTLV-1-associated diseases may occur in carriers who are transplanted but there is insufficient evidence to confirm whether these occur more frequently as a result of the associated immunosuppression. Consequently, pre-existing HTLV-1 infection should not be considered a contra-indication to transplantation. The risk of transmission of HTLV-1 through solid organ transplantation from a confirmed infected donor is unknown...
January 29, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29373673/a-17-year-old-boy-with-right-face-palsy-left-leg-weakness-and-lytic-skull-bone-lesions
#14
Ibukunoluwa C Akinboyo, Genevieve M Crane, Lingling Chen, Ravit Arav-Boger
Human T-cell lymphotropic virus (HTLV), an infection that is endemic in certain parts of Asia, Africa, and South America, has been associated with malignancy and neurological deficits. Here, we describe a pediatric patient with chronic HTLV-I infection who developed complications associated with HTLV-I (ie, adult T-cell leukemia/lymphoma and HTLV-I-associated myelopathy/tropical spastic paraparesis). To our knowledge, this presentation in a child has never been described. The patient underwent a bone marrow transplant and, at the time of this writing, was in remission...
January 24, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29358408/sporadic-on-off-switching-of-htlv-1-tax-expression-is-crucial-to-maintain-the-whole-population-of-virus-induced-leukemic-cells
#15
Mohamed Mahgoub, Jun-Ichirou Yasunaga, Shingo Iwami, Shinji Nakaoka, Yoshiki Koizumi, Kazuya Shimura, Masao Matsuoka
Viruses causing chronic infection artfully manipulate infected cells to enable viral persistence in vivo under the pressure of immunity. Human T-cell leukemia virus type 1 (HTLV-1) establishes persistent infection mainly in CD4+ T cells in vivo and induces leukemia in this subset. HTLV-1-encoded Tax is a critical transactivator of viral replication and a potent oncoprotein, but its significance in pathogenesis remains obscure due to its very low level of expression in vivo. Here, we show that Tax is expressed in a minor fraction of leukemic cells at any given time, and importantly, its expression spontaneously switches between on and off states...
January 22, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29346571/natural-course-of-htlv-1-proviral-dna-levels-in-carriers-during-pregnancy
#16
Naoki Fuchi, Kiyonori Miura, Takashi Tsukiyama, Daisuke Sasaki, Kaori Ishihara, Kazuto Tsuruda, Hiroo Hasegawa, Shoko Miura, Katsumi Yanagihara, Hideaki Masuzaki
The measurement of human T-cell leukemia virus type 1 (HTLV-1) proviral DNA levels using polymerase chain reaction has been beneficial for confirming HTLV-1 infection during pregnancy. However, the influence of pregnancy on HTLV-1 infection and proviral DNA levels among pregnant women with HTLV-1 has not been clarified. We prospectively gathered blood samples from 36 pregnant women who were previously diagnosed as HTLV-1 carriers and sequentially measured their proviral DNA levels. The HTLV-1 proviral DNA levels remained in a plateau during pregnancy but were elevated after delivery...
January 16, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29325864/infections-genetic-and-environmental-factors-in-pathogenesis-of-autoimmune-thyroid-diseases
#17
REVIEW
Sanjeev Kumar Shukla, Govind Singh, Shahzad Ahmad, Prabhat Pant
In Autoimmune disease a combination of infection, genetic and environmental factors causes an autoimmune response to the thyroid gland (characterized by lymphocytic infiltrations), thyroid stimulating hormone receptor (TSHR) and different thyroid antigens. Graves' and Hashimoto disease are autoimmune disorders with genetic predisposition. CD40 that stimulates the proliferation and differentiation of lymphocytes is an essential immunomodulatory component for follicular cells in the thyroid and the cell that present the antigen...
January 8, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29322517/discordant-human-t-lymphotropic-virus-screening-with-western-blot-confirmation-evaluation-of-the-dual-test-algorithm-for-us-blood-donations
#18
Susan L Stramer, Rebecca L Townsend, Gregory A Foster, Ramona Johnson, Barbara Weixlmann, Roger Y Dodd
BACKGROUND: Human T-lymphotropic virus (HTLV) blood donation screening has used a dual-testing algorithm beginning with either a chemiluminescent immunoassay or enzyme-linked immunosorbent screening assay (ELISA). Before the availability of a licensed HTLV supplemental assay, repeat-reactive (RR) samples on a first assay (Assay 1) were retested with a second screening assay (Assay 2). Donors with RR results by Assay 2 were deferred from blood donation and further tested using an unlicensed supplemental test to confirm reactivity while nonreactive (NR) donors remained eligible for donation until RR on a subsequent donation...
January 10, 2018: Transfusion
https://www.readbyqxmd.com/read/29318453/sensory-neuronopathy-heralding-human-t-cell-lymphotropic-virus-type-i-myelopathy
#19
Alberto R M Martinez, Raphael F Casseb, Carlos R Martins, Anamarli Nucci, Marcondes C França
Neurological phenotypes of human T cell lymphotropic virus type I (HTLV-1) are numerous and rarely may not manifest the classic HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We report a case of HTLV-1-related sensory neuronopathy heralding the classic HAM/TSP.
January 9, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29296760/clonality-of-htlv-1-infected-t-cells-as-a-risk-indicator-for-development-and-progression-of-adult-t-cell-leukemia
#20
Sanaz Firouzi, Amir Farmanbar, Kenta Nakai, Masako Iwanaga, Kaoru Uchimaru, Atae Utsunomiya, Yutaka Suzuki, Toshiki Watanabe
Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1) that develops along a carcinogenic process involving 5 or more genetic events in infected cells. The lifetime incidence of ATL among HTLV-1-infected individuals is approximately 5%. Although epidemiologic studies have revealed risk factors for ATL, the molecular mechanisms that determine the fates of carriers remain unclear. A better understanding of clonal composition and related longitudinal dynamics would clarify the process of ATL leukemogenesis and provide insights into the mechanisms underlying the proliferation of a malignant clone...
June 27, 2017: Blood Advances
keyword
keyword
13498
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"