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https://www.readbyqxmd.com/read/28432200/tissue-adaptation-implications-for-gut-immunity-and-tolerance
#1
REVIEW
Ana M C Faria, Bernardo S Reis, Daniel Mucida
Tissue adaptation is an intrinsic component of immune cell development, influencing both resistance to pathogens and tolerance. Chronically stimulated surfaces of the body, in particular the gut mucosa, are the major sites where immune cells traffic and reside. Their adaptation to these environments requires constant discrimination between natural stimulation coming from harmless microbiota and food, and pathogens that need to be cleared. This review will focus on the adaptation of lymphocytes to the gut mucosa, a highly specialized environment that can help us understand the plasticity of leukocytes arriving at various tissue sites and how tissue-related factors operate to shape immune cell fate and function...
April 21, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28431896/pressurized-intraperitoneal-aerosol-chemotherapy-%C3%A2-practical-aspects
#2
M Hübner, F Grass, H Teixeira-Farinha, B Pache, P Mathevet, N Demartines
INTRODUCTION: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) has been introduced as novel treatment for peritoneal carcinomatosis. Only proper patient selection, stringent safety protocol and careful surgery allow for a secure procedure. We hereby report the essentials for safe implementation. METHODS: All consecutive procedures within 20 months after PIPAC implementation were analyzed with regards to practical and surgical aspects. Special emphasis was laid on modifications of technique and safety measures during the implementation process with systematic use of a dedicated checklist...
April 8, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28431451/-experience-with-the-hind-foot-relaxation-boot
#3
Hans Zwipp, Michael Borrmann, Eberhard Walter
The goal of this paper is to report our experience with hindfoot fractures using our specially developed boot, with a follow-up of 557 cases. This boot works like the well-known Allgöwer-Röck ortheses (ARO), but is a hybrid between a boot and an orthesis. It allows full weightbearing without using crutches and completely protects an acutely operated hind foot fracture, hind foot arthrodesis or a hind foot fracture which is suitable for conservative treatment. In its first generation, this boot was custom made and used in 408 cases, from March 1999 to February 2011...
April 21, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28429987/beyond-integrated-care
#4
Thomas Plochg, Stefania Ilinca, Mirko Noordegraaf
Integrated care tops the health care agenda. But more integration alone will not remedy the crisis in health care, and there is a danger in the increasingly prevalent conceptualization of care integration as a goal in itself rather than as an instrument for improving performance. Operating integrated care systems, staffed by an overly specialized medical workforce, is unsustainable in terms of human and financial resources and is likely to produce little benefit for patients with multi-morbidity. An alternative approach involves health care leaders going beyond integrated care and nurturing transformative change from within the medical workforce instead...
January 1, 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/28429729/weak-connections-form-an-infinite-number-of-patterns-in-the-brain
#5
Hai-Peng Ren, Chao Bai, Murilo S Baptista, Celso Grebogi
Recently, much attention has been paid to interpreting the mechanisms for memory formation in terms of brain connectivity and dynamics. Within the plethora of collective states a complex network can exhibit, we show that the phenomenon of Collective Almost Synchronisation (CAS), which describes a state with an infinite number of patterns emerging in complex networks for weak coupling strengths, deserves special attention. We show that a simulated neuron network with neurons weakly connected does produce CAS patterns, and additionally produces an output that optimally model experimental electroencephalograph (EEG) signals...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28425912/how-spatial-release-from-masking-may-fail-to-function-in-a-highly-directional-auditory-system
#6
Norman Lee, Andrew C Mason
Spatial release from masking (SRM) occurs when spatial separation between a signal and masker decreases masked thresholds. The mechanically-coupled ears of Ormia ochracea are specialized for hyperacute directional hearing, but the possible role of SRM, or whether such specializations exhibit limitations for sound source segregation, is unknown. We recorded phonotaxis to a cricket song masked by band-limited noise. With a masker, response thresholds increased and localization was diverted away from the signal and masker...
April 20, 2017: ELife
https://www.readbyqxmd.com/read/28424996/-quality-assurance-of-pain-care-in-austria-classification-of-management-facilities
#7
REVIEW
Wolfgang Jaksch, Rudolf Likar, Erika Folkes, Klaus Machold, Friedrich Herbst, Katharina Pils, Peter Stippl, Sandra Lettner, Mildred Alfons, Richard Crevenna, Christian Wiederer, Janina Dieber, Reinhold Glehr
In Austria there is no nationwide coverage of pain management, which meets even approximately international criteria. At present there are about 30 interdisciplinary pain management offices and clinics providing care according to a concept of the Austrian Pain Society (ÖSG), about 10 other outpatient pain clinics are located in district and country hospitals. A few years ago, there still were about 50 pain clinics. Yet closure of outpatient clinics and cost-cutting measures in the health sector jeopardize adequate pain relief for patients with chronic pain conditions...
April 19, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28423982/from-data-to-improved-decisions-operations-research-in-healthcare-delivery
#8
Muge Capan, Anahita Khojandi, Brian T Denton, Kimberly D Williams, Turgay Ayer, Jagpreet Chhatwal, Murat Kurt, Jennifer Mason Lobo, Mark S Roberts, Greg Zaric, Shengfan Zhang, J Sanford Schwartz
BACKGROUND: The Operations Research Interest Group (ORIG) within the Society of Medical Decision Making (SMDM) is a multidisciplinary interest group of professionals that specializes in taking an analytical approach to medical decision making and healthcare delivery. ORIG is interested in leveraging mathematical methods associated with the field of Operations Research (OR) to obtain data-driven solutions to complex healthcare problems and encourage collaborations across disciplines. This paper introduces OR for the non-expert and draws attention to opportunities where OR can be utilized to facilitate solutions to healthcare problems...
April 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28422358/is-mean-platelet-volume-a-better-biomarker-in-pre-eclampsia
#9
Gustavo Vilchez, Moraima Lagos, Komal Kumar, Pedro Argoti
AIM: Platelet activation and destruction is a well recognized feature of pre-eclampsia, but the current literature is contradictory regarding the role of mean platelet volume (MPV) in the diagnosis of this condition. We investigated whether MPV, compared with other routine laboratory markers such as platelet count, is a more significant biomarker of pre-eclampsia, giving special attention to the intrapartum period. METHODS: Biochemical and hematological markers along pregnancy including MPV were compared retrospectively between pre-eclampsia and matched controls...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28421117/chronic-pain-in-children-a-look-at-the-referral-process-to-a-pediatric-pain-clinic
#10
Giovanni Cucchiaro, Jennifer Schwartz, Alec Hutchason, Beatriz Ornelas
We reviewed the referral pattern of children with chronic pain to a specialized pediatric pain clinic. Data were obtained from referring physicians and medical records and during an interview with patients and their parents by physicians and a psychologist. We analyzed the following: referral diagnosis, demographics, duration of symptoms, number of physicians previously consulted, school attendance, sports activities, presence of psychological disorders, final team diagnosis, and outcomes. Children had been experiencing pain for 34 ± 55 months...
2017: International Journal of Pediatrics
https://www.readbyqxmd.com/read/28420329/contrast-enhanced-us-with-perfluorobutane-sonazoid-used-as-a-surveillance-test-for-hepatocellular-carcinoma-hcc-in-cirrhosis-scan-an-exploratory-cross-sectional-study-for-a-diagnostic-trial
#11
Ji Hoon Park, Mi-Suk Park, So Jung Lee, Woo Kyoung Jeong, Jae Young Lee, Min Jung Park, Kyunghwa Han, Chung Mo Nam, Seong Ho Park, Kyoung Ho Lee
BACKGROUND: Ultrasonography (US) is widely used as a standard surveillance tool for patients who are at a high risk of having hepatocellular carcinoma (HCC); however, conventional B-mode US appears to be insufficient in order to ensure the early detection of HCC. Perfluorobutane allows very stable Kupffer phase imaging for at least 60 min, which is tolerable for examinations of the entire liver. The purpose of our study is to evaluate the added value of contrast-enhanced US using perfluorobutane to that of conventional B-mode US as an HCC surveillance tool for patients with liver cirrhosis...
April 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28419616/the-provision-of-pediatric-cardiac-anesthesia-services-in-germany-current-status-of-structural-and-personnel-organization
#12
Torsten Baehner, Oliver Dewald, Ingo Heinze, Matthias Mueller, Ehrenfried Schindler, Uwe Schirmer, Georg Baumgarten, Andreas Hoeft, Richard K Ellerkmann
BACKGROUND: Anesthesia for pediatric cardiac surgery requires a high level of expert knowledge. There are currently no recommendations and standards for anesthetic management for congenital cardiac surgery in Germany. AIM: The aim of the present study was to assess the current status of structural and personnel anesthetic standards at pediatric cardiac surgery centers in Germany. METHOD: All cardiac surgical centers in Germany were reviewed for an active program for congenital heart surgery...
April 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28418438/a-scalable-self-priming-fractal-branching-microchannel-net-chip-for-digital-pcr
#13
Qiangyuan Zhu, Yanan Xu, Lin Qiu, Congcong Ma, Bingwen Yu, Qi Song, Wei Jin, Qinhan Jin, Jinyu Liu, Ying Mu
As an absolute quantification method at the single-molecule level, digital PCR has been widely used in many bioresearch fields, such as next generation sequencing, single cell analysis, gene editing detection and so on. However, existing digital PCR methods still have some disadvantages, including high cost, sample loss, and complicated operation. In this work, we develop an exquisite scalable self-priming fractal branching microchannel net digital PCR chip. This chip with a special design inspired by natural fractal-tree systems has an even distribution and 100% compartmentalization of the sample without any sample loss, which is not available in existing chip-based digital PCR methods...
April 18, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28417431/robotic-kidney-transplantation-an-update
#14
REVIEW
V Sankaran, S Sinha
PURPOSE OF REVIEW: Over the last decade, there have been advances in kidney transplantation with introduction of minimally invasive surgery. Robotic surgery is becoming increasingly common across the specialities. There is now increasing experience in robotic kidney transplantation, though it remains a niche procedure. Initial reports suggest that this is a safe, feasible operation when performed by teams familiar with robotic surgery. There have been a few modifications to the initially described procedure, as a result of increasing experience...
June 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28417027/decision-to-delivery-time-intervals-in-emergency-caesarean-section-cases-repeated-cross-sectional-study-from-oman
#15
Kaukab Tashfeen, Malini Patel, Ilham M Hamdi, Ibrahim H A Al-Busaidi, Mansour N Al-Yarubi
OBJECTIVES: In cases of fetal intolerance to labour, meeting the standard decision-to-delivery time interval (DDI) of ≤30 minutes is challenging. This study aimed to assess DDIs in emergency Caesarean section (CS) cases to identify factors causing DDI delays and the impact of a delayed DDI on perinatal outcomes. METHODS: This repeated cross-sectional study included all emergency CS procedures performed due to acute fetal distress, antepartum haemorrhage or umbilical cord prolapse at the Nizwa Hospital, Nizwa, Oman...
February 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28416827/-comparison-of-the-effects-of-total-hip-arthroplasty-via-direct-anterior-approach-and-posterolateral-piriformis-sparing-approach
#16
J Xu, W D Zhuang, X W Li, G Y Yu, Y Lin, F Q Luo, Y H Xiao
OBJECTIVE: To compare the clinical effects of direct anterior approach (DAA) and posterolateral piriformis-sparing approach (Mis-PLA) for minimally invasive surgery of total hip arthroplasty. METHODS: The patients who had total hip arthroplasty from March 2015 to February 2016 were randomly divided into 2 groups: DAA group and Mis-PLA group. In the study, 43 patients (45 hips) were performed with total hip replacement via the direct anterior approach (DAA group)...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28413139/evaluation-of-extensor-mechanism-in-revision-knee-arthroplasty
#17
Vadym Zhamilov, Vasfi Karatosun, Serpil Kalkan, Bayram Unver, Izge Gunal
BACKGROUND: The success of revision total knee arthroplasty depends on adequate exposure that does not produce complications. The purpose of this study was to compare the results of revision total knee arthroplasty between V-Y quadricepsplasty (QP) and quadriceps snip (QS) approaches. METHODS: In the study, 92 knees with follow-up of 12-108 months which were operated by using QP (55) and QS (37) were evaluated retrospectively. Measurements were taken by using universal transparent goniometer, also varus valgus deformities, knee flexion angles, instability, Hospital for Special Surgery and Lower Extremity Functional Scale scores, functional condition of the knee and activity levels of the patients were evaluated cross-sectionally...
March 22, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28412539/laparoscopic-reoperative-anti-reflux-surgery-is-more-cost-effective-than-open-approach
#18
Farzaneh Banki, Matthew Weaver, David Roife, Chandni Kaushik, Anshu Khanna, Kelly Ochoa, Charles C Miller
BACKGROUND: We previously reported the outcomes of laparoscopic and open reoperative antireflux surgery. The aim of this study was to compare costs. METHODS: Retrospective review. Financial and procedure coding data were obtained using a cost accounting system. There were 49 procedures in 46 patients: 36 females/10 males. There were 38 laparoscopic (including 4 conversions); and 11 open procedures (7 transabdominal repairs and 4 gastric preserving Roux-en-Y esophagojejunostomy)...
April 12, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28411354/preventing-the-complications-associated-with-the-use-of-dermal-fillers-in-facial-aesthetic-procedures-an-expert-group-consensus-report
#19
REVIEW
Fernando Urdiales-Gálvez, Nuria Escoda Delgado, Vitor Figueiredo, José V Lajo-Plaza, Mar Mira, Francisco Ortíz-Martí, Rosa Del Rio-Reyes, Nazaret Romero-Álvarez, Sofía Ruiz Del Cueto, María A Segurado, Cristina Villanueva Rebenaque
BACKGROUND: The use of dermal fillers in minimally invasive facial aesthetic procedures has become increasingly popular of late, yet as the indications and the number of procedures performed increase, the number of complications is also likely to increase. Paying special attention to specific patient characteristics and to the technique used can do much to avoid these complications. Indeed, a well-trained physician can also minimize the impact of such problems when they do occur. METHODS: A multidisciplinary group of experts in aesthetic treatments reviewed the main factors associated with the complications that arise when using dermal fillers...
April 14, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28411272/disconnection-of-the-perirhinal-and-postrhinal-cortices-impairs-recognition-of-objects-in-context-but-not-contextual-fear-conditioning
#20
Victoria R Heimer-McGinn, D L Poeta, K Aghi, M Udawatta, R D Burwell
The perirhinal cortex (PER) is known to process object information, whereas the rodent postrhinal cortex (POR), homolog to the parahippocampal cortex (PHC) in primates, is thought to process spatial information. A number of studies, however, provide evidence that both areas are involved in processing contextual information. In this study, we tested the hypothesis that the rat POR relies on object information received from the PER to form complex representations of context. Using three fear conditioning paradigms (signaled, unsignaled, and renewal) and two context-guided object recognition tasks (with 3-dimensional and 2-dimensional objects), we examined the effects of crossed excitotoxic lesions to the POR and the contralateral PER...
April 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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