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Eastern hepatobiliary surgery hospital

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https://www.readbyqxmd.com/read/29224266/-application-of-liver-three-dimensional-visualization-technologies-in-the-treatment-planning-of-hepatic-malignant-tumor
#1
P P Li, Z H Wang, G Huang, Z P Huang, Y Li, J S Ni, H Liu, C H Fang, W P Zhou
Objective: To discuss the application of three dimentional(3D)visualization technologies in treatment plan of hepatic malignant tumor. Methods: The clinical data of 300 patients with liver malignant tumor who received treatment from January 2016 to January 2017 in the Third Department of Hepatic Surgery of Eastern Hepatobiliary Surgery Hospital was retrospectively analyzed in this study, including 221 male and 79 female patients aged from 7 to 76 years with median age of 54 years. The median height was 168 cm (115-183 cm), the median weight was 65 kg (20-105 kg) and the median tumor volume was 142 ml (23-2 493 ml)...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29152084/the-stromal-morphological-changes-for-differential-diagnosis-of-uninodular-high-grade-dysplastic-nodule-and-well-differentiated-small-hepatocellular-carcinoma
#2
Long-Hai Feng, Han Wang, Hui Dong, Yu-Yao Zhu, Wen-Ming Cong
Aim: The stromal invasion has been regarded as the most valuable clue to distinguish high-grade dysplastic nodules (HGDNs) and well-differentiated small hepatocellular carcinomas (WD-SHCCs). The purposes of this study are to explore the stromal morphological changes for the differential diagnosis of these two equivocal lesions. Results: Based on the systemic studies of histological characteristics of HGDNs and WD-SHCCs, the stromal morphological changes, including sinusoid capillarization, ductular reaction and solitary artery, were performed to make a differential diagnosis between them...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133751/shanghai-score-a-prognostic-and-adjuvant-treatment-evaluating-system-constructed-for-chinese-patients-with-hepatocellular-carcinoma-after-curative-resection
#3
Hui-Chuan Sun, Lu Xie, Xin-Rong Yang, Wei Li, Jian Yu, Xiao-Dong Zhu, Yong Xia, Ti Zhang, Yang Xu, Bo Hu, Li-Ping Du, Ling-Yao Zeng, Jian Ouyang, Wei Zhang, Tian-Qiang Song, Qiang Li, Ying-Hong Shi, Jian Zhou, Shuang-Jian Qiu, Qian Liu, Yi-Xue Li, Zhao-You Tang, Yu Shyr, Feng Shen, Jia Fan
BACKGROUND: For Chinese patients with hepatocellular carcinoma (HCC), surgical resection is the most important treatment to achieve long-term survival for patients with an early-stage tumor, and yet the prognosis after surgery is diverse. We aimed to construct a scoring system (Shanghai Score) for individualized prognosis estimation and adjuvant treatment evaluation. METHODS: A multivariate Cox proportional hazards model was constructed based on 4166 HCC patients undergoing resection during 2001-2008 at Zhongshan Hospital...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29033225/nomograms-for-prediction-of-long-term-survival-in-elderly-patients-after-partial-hepatectomy-for-hepatocellular-carcinoma
#4
Zhangjun Cheng, Pinghua Yang, Zhengqing Lei, Baohua Zhang, Anfeng Si, Zhenglin Yan, Yong Xia, Jun Li, Kui Wang, Daniel Hartmann, Norbert Hüser, Wan Yee Lau, Feng Shen
BACKGROUND: Partial hepatectomy is an important treatment for elderly patients with hepatocellular carcinoma. However, prediction of long-term outcomes of an individual elderly patient after partial hepatectomy still is lacking. This study aimed to develop 2 nomograms to pre- or postoperatively predict overall survival for these patients. METHODS: Of the 528 elderly patients (aged ≥65 years) who underwent partial hepatectomy for hepatocellular carcinoma at the Eastern Hepatobiliary Surgery Hospital between 2008 and 2011, 425 patients served as a training cohort to develop pre- and postoperative nomograms, and the remaining 103 patients comprised a validation cohort...
December 2017: Surgery
https://www.readbyqxmd.com/read/28562348/actual-over-10-year-survival-after-liver-resection-for-patients-with-intrahepatic-cholangiocarcinoma
#5
Anfeng Si, Jun Li, Hongjun Xiang, Shichao Zhang, Shilei Bai, Pinghua Yang, Xiaofeng Zhang, Yong Xia, Kui Wang, Zhenlin Yan, Wan Yee Lau, Lehua Shi, Feng Shen
Partial hepatectomy is a potentially curative therapy for intrahepatic cholangiocarcinoma (ICC). Unfortunately, the overall surgical prognosis remains dismal and the actual 10-year survival has not been reported. This study aimed to document 10-year actual survival rates, identify the prognostic factors associated with 10-year survival rate, and analyze the characteristics of patients who survived ≥ 10 years. Among 251 patients who underwent curative liver resection for ICC between 2003 and 2006 at the Eastern Hepatobiliary Surgery Hospital, 21 patients (8...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28103953/microwave-ablation-is-as-effective-as-radiofrequency-ablation-for-very-early-stage-hepatocellular-carcinoma
#6
Yun Xu, Qiang Shen, Neng Wang, Pan-Pan Wu, Bin Huang, Ming Kuang, Guo-Jun Qian
BACKGROUND: Percutaneous radiofrequency ablation (RFA) is a first-line treatment for very-early-stage hepatocellular carcinoma (HCC), whereas the efficacy of percutaneous microwave ablation (MWA) for very-early-stage HCC remains unclear. The purpose of this study was to clarify this issue by comparing the safety and efficacy of percutaneous MWA with percutaneous RFA in treating very-early-stage HCC. METHODS: Clinical data of 460 patients who were diagnosed with very-early-stage HCC and treated with percutaneous MWA or RFA between January 2007 and July 2012 at the Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, in Shanghai, China were retrospectively analyzed...
January 19, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28058554/prognosis-of-intrahepatic-cholangiocarcinomas-with-hbv-infection-is-better-than-those-with-hepatolithiasis-after-r0-liver-resection-a-propensity-score-matching-analysis
#7
Qing Wang, Jun Li, Zhengqing Lei, Dong Wu, Anfeng Si, Kui Wang, Yizhou Wang, Xuying Wan, Wan Yee Lau, Feng Shen
BACKGROUND: The impact of different causative factors of intrahepatic cholangiocarcinoma (ICC) on disease outcome remains largely unknown. This study aimed to evaluate the prognosis of ICC patients with different pathogenic factors after hepatectomy. METHODS: Data of 731 consecutive patients undergoing R0 liver resection for ICC at The Eastern Hepatobiliary Surgery Hospital between 2004 and 2010 were analyzed. These patients were divided into the hepatitis B virus-related (HBV-ICC, n = 519), hepatolithiasis-related (stone-ICC, n = 87), HBV plus hepatolithiasis-related (HBV/stone-ICC, n = 45), and other etiologies-related (other-ICC, n = 80) ICC groups...
June 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27989605/effectiveness-of-repeat-hepatic-resection-for-patients-with-recurrent-intrahepatic-cholangiocarcinoma-factors-associated-with-long-term-outcomes
#8
Anfeng Si, Jun Li, Xianglei Xing, Zhengqing Lei, Yong Xia, Zhenlin Yan, Kui Wang, Lehua Shi, Feng Shen
BACKGROUND: Tumor recurrence after liver resection for intrahepatic cholangiocarcinoma is common. The effective treatment for recurrent intrahepatic cholangiocarcinoma remains to be established. This study evaluated the short- and long-term prognoses of patients after repeat hepatic resection for recurrent intrahepatic cholangiocarcinoma. METHODS: Data for 72 patients who underwent R0 repeat hepatic resection for recurrent intrahepatic cholangiocarcinoma at the Eastern Hepatobiliary Surgery Hospital between 2005 and 2013 were analyzed...
April 2017: Surgery
https://www.readbyqxmd.com/read/27923614/antiviral-therapy-inhibits-viral-reactivation-and-improves-survival-after-repeat-hepatectomy-for-hepatitis-b-virus-related-recurrent-hepatocellular-carcinoma
#9
Shengyu Huang, Yong Xia, Zhengqing Lei, Qifei Zou, Jun Li, Tian Yang, Kui Wang, Zhenlin Yan, Xuying Wan, Feng Shen
BACKGROUND: The aim of this study was to explore the impact of antiviral therapy (AVT) on short- and long-term outcomes after rehepatectomy for patients with recurrent hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). STUDY DESIGN: We analyzed data from 583 consecutive patients who underwent rehepatectomy for intrahepatic recurrence of HBV-related HCC after initial hepatectomy, between 2006 and 2011 at the Eastern Hepatobiliary Surgery Hospital. Tumor re-recurrence, recurrence to death survival (RTDS), and overall survival (OS) were compared using the Kaplan-Meier method and log-rank test...
March 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27587210/-application-of-liver-visualization-technologies-in-hilar-tumor-resection-at-the-second-hepatic-portal-area
#10
P P Li, H Liu, S Y Fu, C Lin, Z Y Pan, J Zhang, J S Ni, S X Yuan, W P Zhou
OBJECTIVE: To discuss the application of liver visualization technology in complex liver tumor resection at the second hepatic portal area. METHODS: Clinical data of 80 cases who received surgery at the second hepatic portal area from August 2014 to September 2015 in the Third Department of Hepatic Surgery of Eastern Hepatobiliary Surgery Hospital were analyzed retrospectively. There were 58 male and 22 female patients aged from 21 to 70 years with median age of 52 years...
September 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27512855/surgical-treatment-of-double-primary-liver-cancer-an-observational-study-for-a-rare-type-of-tumor
#11
Aijun Li, Senlin Ma, Timothy Pawlik, Bin Wu, Xiaoyu Yang, Longjiu Cui, Mengchao Wu
Double primary liver cancer (DPLC) is a special type of clinical situation. As such, a detailed analysis of the surgical management and prognosis of patients with DPLC is lacking. The objective of the current study was to define the management and outcome of patients undergoing surgery for DPLC at a major hepatobiliary center.A total of 87 patients treated by surgical resection at the Eastern Hepatobiliary Surgery Hospital from January 1st, 2007 to October 31st, 2013 who had DPLC demonstrated by final pathological diagnosis were identified...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27232330/nomograms-for-survival-prediction-in-patients-undergoing-liver-resection-for-hepatitis-b-virus-related-early-stage-hepatocellular-carcinoma
#12
Jun Li, Jian Zhou, Ping-Hua Yang, Yong Xia, Ying-Hong Shi, Dong Wu, Gang Lv, Wang Zheng, Kui Wang, Xu-Ying Wan, Wan Yee Lau, Meng-Chao Wu, Jia Fan, Feng Shen
BACKGROUND: The long-term outcomes of patients who underwent liver resection (LR) for early-stage hepatitis B virus (HBV)-related hepatocellular carcinomas (HCCs) are difficult to predict. This study aimed to develop two nomograms to predict postoperative disease-free survival (DFS) and overall survival (OS), respectively. METHODS: Data on a primary cohort of 1328 patients who underwent LR for HBV-related HCCs within Milan criteria at the Eastern Hepatobiliary Surgery Hospital (EHBH) from 2000 to 2006 were used to develop the nomograms by the Cox regression analyses...
July 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27144432/establishment-and-validation-of-a-prognostic-nomogram-for-patients-with-resectable-perihilar-cholangiocarcinoma
#13
Peizhan Chen, Bin Li, Yan Zhu, Wei Chen, Xin Liu, Mian Li, Xiaohua Duan, Bin Yi, Jinghan Wang, Chen Liu, Xiangji Luo, Xiaoguang Li, Jingquan Li, Lijian Liang, Xiaoyu Yin, Hui Wang, Xiaoqing Jiang
As the conventional staging systems have poor prognosis prediction ability for patients with perihilar cholangiocarcinoma (pCCA), we established and validated an effective prognostic nomogram for pCCA patients based on their personal and tumor characteristics. A total of 235 patients who received curative intent resections at the Eastern Hepatobiliary Surgery Hospital from 2000 to 2009 were recruited as the primary training cohort. Age, preoperative CA19-9 levels, portal vein involvement, hepatic artery invasion, lymph node metastases, and surgical treatment outcomes (R0 or R1/2) were independent prognostic factors for pCCA patients in the primary cohort as suggested by the multivariate analyses and these were included in the established nomogram...
June 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27027439/a-novel-scoring-system-predicts-adjuvant-chemolipiodolization-benefit-for-hepatocellular-carcinoma-patients-after-hepatectomy
#14
Li-Feng Huang, Xianglei Xing, Dong Wu, Yong Xia, Jun Li, Kui Wang, Zhen-Lin Yan, Xu-Ying Wan, Le-Hua Shi, Tian Yang, Wan Yee Lau, Meng-Chao Wu, Feng Shen
Our aim in this study was to develop a prognostic scoring system with which to identify patients most likely to benefit from adjuvant chemolipiodolization (ACL) after liver resection for hepatocellular carcinoma (HCC). Data from 1150 HCC patients who underwent liver resection between 2002 and 2008 at the Eastern Hepatobiliary Surgery Hospital were used to develop the scoring system. Patients were stratified into prognostic subgroups using the new scoring system, and the outcomes of patients who received ACL and those who did not were compared in each subgroup...
May 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/26903045/nomograms-for-pre-operative-and-post-operative-prediction-of-long-term-survival-of-patients-who-underwent-repeat-hepatectomy-for-recurrent-hepatocellular-carcinoma
#15
Qifei Zou, Jun Li, Dong Wu, Zhenlin Yan, Xuying Wan, Kui Wang, Lehua Shi, Wan Yee Lau, Mengchao Wu, Feng Shen
BACKGROUND: Repeat hepatectomy (re-hepatectomy) is an effective treatment for patients with intrahepatic recurrence following liver resection for hepatocellular carcinoma (HCC). OBJECTIVE: This study aimed to develop nomograms for predicting prognosis after re-hepatectomy. METHODS: The data of 635 patients who underwent re-hepatectomy for recurrent HCC at the Eastern Hepatobiliary Surgery Hospital between 2004 and 2010 were prospectively collected...
August 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26823044/prognostic-factors-for-survival-after-hepatic-resection-of-early-hepatocellular-carcinoma-in-hbv-related-cirrhotic-patients
#16
Qian Zhu, Bo Yuan, Guo-Liang Qiao, Jian-Jun Yan, Yun Li, Rui Duan, Yi-Qun Yan
OBJECTIVE: The study aimed to identify clinico-pathologic factors that predict survival in early hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV)-related cirrhosis undergoing liver resection. METHODS: A population-based cohort was investigated to identify cirrhotic patients with confirmed early HCC (tumor size≤5cm and absence of nodal involvement, metastases, or major vascular invasion) after hepatic resection at the Eastern Hepatobiliary Surgery Hospital (Shanghai, China) from April 2005 and November 2010 using the Surveillance, Epidemiology, and End Results (SEER) database...
September 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/26579636/nomogram-for-preoperative-estimation-of-microvascular-invasion-risk-in-hepatitis-b-virus-related-hepatocellular-carcinoma-within-the-milan-criteria
#17
Zhengqing Lei, Jun Li, Dong Wu, Yong Xia, Qing Wang, Anfeng Si, Kui Wang, Xuying Wan, Wan Yee Lau, Mengchao Wu, Feng Shen
IMPORTANCE: The presence of microvascular invasion (MVI) decreases surgical outcomes of hepatocellular carcinoma (HCC). An accurate preoperative prediction of MVI can help surgeons to better choose surgical procedures, but accuracy is still difficult to achieve. OBJECTIVE: To develop a nomogram to predict MVI presence before liver resection for hepatitis B virus (HBV)-related HCC within the Milan criteria (solitary nodule ≤5 cm; ≤3 nodules, none >3 cm; and no macrovascular invasion)...
April 2016: JAMA Surgery
https://www.readbyqxmd.com/read/26382973/prognostic-nomograms-for-pre-and-postoperative-predictions-of-long-term-survival-for-patients-who-underwent-liver-resection-for%C3%A2-huge%C3%A2-hepatocellular-carcinoma
#18
Yuntong Li, Yong Xia, Jun Li, Dong Wu, Xuying Wan, Kui Wang, Mengchao Wu, Jingfeng Liu, Wan Yee Lau, Feng Shen
BACKGROUND: Liver resection is an effective treatment in select patients with huge hepatocellular carcinoma (HCC, diameter ≥10 cm). This study aimed to develop nomograms for pre- and postoperative predictions of overall survival (OS) for these patients. STUDY DESIGN: There were 464 consecutive patients who underwent liver resection for huge HCC at the Eastern Hepatobiliary Surgery Hospital (EHBH) between January 2008 and December 2009. They were collected and divided into a training cohort (n = 310) and an internal validation cohort (n = 154)...
November 2015: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/26136881/cidan-inhibits-liver-cancer-cell-growth-by-reducing-cox-2-and-vegf-expression-and-cell-cycle-arrest
#19
Nan Li, Donghai Zheng, Jie Xue, Weixing Guo, Jie Shi, Juxian Sun, Chongde Lu, Weida Zheng, Mengchao Wu, Shuqun Cheng
Cidan is a traditional Chinese medicine formula that has been used for >10 years as an antitumor drug. In the present study, the antitumor effect of cidan on hepatocellular carcinoma (HCC) and the underlying molecular mechanisms were investigated. A total of 372 patients with primary HCC, as confirmed by pathological examination in the Eastern Hepatobiliary Surgery Hospital and Beijing Oncology Hospital of Weida TCM, were prospectively enrolled in the study. In total, 92 patients were treated with cidan capsules for three months postoperatively, while 280 patients served as controls...
May 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26135698/nomograms-for-pre-and-postoperative-prediction-of-long-term-survival-for-patients-who-underwent-hepatectomy-for-multiple-hepatocellular-carcinomas
#20
Pinghua Yang, Jiliang Qiu, Jun Li, Dong Wu, Xuying Wan, Wan Yee Lau, Yunfei Yuan, Feng Shen
OBJECTIVES: To develop prognostic nomograms for patients undergoing hepatectomy for multiple hepatocellular carcinomas (mHCCs). BACKGROUND: The prognostic prediction after hepatectomy for mHCCs has not been well established. METHODS: A training cohort (n = 540) was analyzed to construct 2 nomograms based separately on data obtained before and after hepatectomy for mHCCs at the Eastern Hepatobiliary Surgery Hospital between 2000 and 2006. The internal and external validations were performed in 2 independent cohorts (n = 180 each) collected from the Eastern Hepatobiliary Surgery Hospital between 2007 and 2010 and the Sun Yat-Sen University between 2000 and 2007...
April 2016: Annals of Surgery
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