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Eastern hepatobiliary surgery hospital

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https://www.readbyqxmd.com/read/27923614/antiviral-therapy-inhibits-viral-reactivation-and-improves-survival-after-repeat-hepatectomy-for-hepatitis-b-virus-related-recurrent-hepatocellular-carcinoma
#1
Shengyu Huang, Yong Xia, Zhengqing Lei, Qifei Zou, Jun Li, Tian Yang, Kui Wang, Zhenlin Yan, Xuying Wan, Feng Shen
BACKGROUND: To explore the impact of antiviral therapy (AVT) on short- and long-term outcomes after re-hepatectomy for patients with recurrent HBV-related hepatocellular carcinoma (HCC). STUDY DESIGN: The data of 583 consecutive patients who underwent re-hepatectomy for intrahepatic recurrence of HBV-related HCC after initial hepatectomy between 2006 and 2011 at the Eastern Hepatobiliary Surgery Hospital were analyzed. Tumor re-recurrence, recurrence to death survival (RTDS) and overall survival (OS) were compared using the Kaplan-Meier method and log-rank test...
December 3, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27587210/-application-of-liver-visualization-technologies-in-hilar-tumor-resection-at-the-second-hepatic-portal-area
#2
P P Li, H Liu, S Y Fu, C Lin, Z Y Pan, J Zhang, J S Ni, S X Yuan, W P Zhou
OBJECTIVE: To discuss the application of liver visualization technology in complex liver tumor resection at the second hepatic portal area. METHODS: Clinical data of 80 cases who received surgery at the second hepatic portal area from August 2014 to September 2015 in the Third Department of Hepatic Surgery of Eastern Hepatobiliary Surgery Hospital were analyzed retrospectively. There were 58 male and 22 female patients aged from 21 to 70 years with median age of 52 years...
September 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27512855/surgical-treatment-of-double-primary-liver-cancer-an-observational-study-for-a-rare-type-of-tumor
#3
Aijun Li, Senlin Ma, Timothy Pawlik, Bin Wu, Xiaoyu Yang, Longjiu Cui, Mengchao Wu
Double primary liver cancer (DPLC) is a special type of clinical situation. As such, a detailed analysis of the surgical management and prognosis of patients with DPLC is lacking. The objective of the current study was to define the management and outcome of patients undergoing surgery for DPLC at a major hepatobiliary center.A total of 87 patients treated by surgical resection at the Eastern Hepatobiliary Surgery Hospital from January 1st, 2007 to October 31st, 2013 who had DPLC demonstrated by final pathological diagnosis were identified...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27232330/nomograms-for-survival-prediction-in-patients-undergoing-liver-resection-for-hepatitis-b-virus-related-early-stage-hepatocellular-carcinoma
#4
Jun Li, Jian Zhou, Ping-Hua Yang, Yong Xia, Ying-Hong Shi, Dong Wu, Gang Lv, Wang Zheng, Kui Wang, Xu-Ying Wan, Wan Yee Lau, Meng-Chao Wu, Jia Fan, Feng Shen
BACKGROUND: The long-term outcomes of patients who underwent liver resection (LR) for early-stage hepatitis B virus (HBV)-related hepatocellular carcinomas (HCCs) are difficult to predict. This study aimed to develop two nomograms to predict postoperative disease-free survival (DFS) and overall survival (OS), respectively. METHODS: Data on a primary cohort of 1328 patients who underwent LR for HBV-related HCCs within Milan criteria at the Eastern Hepatobiliary Surgery Hospital (EHBH) from 2000 to 2006 were used to develop the nomograms by the Cox regression analyses...
July 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27144432/establishment-and-validation-of-a-prognostic-nomogram-for-patients-with-resectable-perihilar-cholangiocarcinoma
#5
Peizhan Chen, Bin Li, Yan Zhu, Wei Chen, Xin Liu, Mian Li, Xiaohua Duan, Bin Yi, Jinghan Wang, Chen Liu, Xiangji Luo, Xiaoguang Li, Jingquan Li, Lijian Liang, Xiaoyu Yin, Hui Wang, Xiaoqing Jiang
As the conventional staging systems have poor prognosis prediction ability for patients with perihilar cholangiocarcinoma (pCCA), we established and validated an effective prognostic nomogram for pCCA patients based on their personal and tumor characteristics. A total of 235 patients who received curative intent resections at the Eastern Hepatobiliary Surgery Hospital from 2000 to 2009 were recruited as the primary training cohort. Age, preoperative CA19-9 levels, portal vein involvement, hepatic artery invasion, lymph node metastases, and surgical treatment outcomes (R0 or R1/2) were independent prognostic factors for pCCA patients in the primary cohort as suggested by the multivariate analyses and these were included in the established nomogram...
June 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27027439/a-novel-scoring-system-predicts-adjuvant-chemolipiodolization-benefit-for-hepatocellular-carcinoma-patients-after-hepatectomy
#6
Li-Feng Huang, Xianglei Xing, Dong Wu, Yong Xia, Jun Li, Kui Wang, Zhen-Lin Yan, Xu-Ying Wan, Le-Hua Shi, Tian Yang, Wan Yee Lau, Meng-Chao Wu, Feng Shen
Our aim in this study was to develop a prognostic scoring system with which to identify patients most likely to benefit from adjuvant chemolipiodolization (ACL) after liver resection for hepatocellular carcinoma (HCC). Data from 1150 HCC patients who underwent liver resection between 2002 and 2008 at the Eastern Hepatobiliary Surgery Hospital were used to develop the scoring system. Patients were stratified into prognostic subgroups using the new scoring system, and the outcomes of patients who received ACL and those who did not were compared in each subgroup...
May 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/26903045/nomograms-for-pre-operative-and-post-operative-prediction-of-long-term-survival-of-patients-who-underwent-repeat-hepatectomy-for-recurrent-hepatocellular-carcinoma
#7
Qifei Zou, Jun Li, Dong Wu, Zhenlin Yan, Xuying Wan, Kui Wang, Lehua Shi, Wan Yee Lau, Mengchao Wu, Feng Shen
BACKGROUND: Repeat hepatectomy (re-hepatectomy) is an effective treatment for patients with intrahepatic recurrence following liver resection for hepatocellular carcinoma (HCC). OBJECTIVE: This study aimed to develop nomograms for predicting prognosis after re-hepatectomy. METHODS: The data of 635 patients who underwent re-hepatectomy for recurrent HCC at the Eastern Hepatobiliary Surgery Hospital between 2004 and 2010 were prospectively collected...
August 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26823044/prognostic-factors-for-survival-after-hepatic-resection-of-early-hepatocellular-carcinoma-in-hbv-related-cirrhotic-patients
#8
Qian Zhu, Bo Yuan, Guo-Liang Qiao, Jian-Jun Yan, Yun Li, Rui Duan, Yi-Qun Yan
OBJECTIVE: The study aimed to identify clinico-pathologic factors that predict survival in early hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV)-related cirrhosis undergoing liver resection. METHODS: A population-based cohort was investigated to identify cirrhotic patients with confirmed early HCC (tumor size≤5cm and absence of nodal involvement, metastases, or major vascular invasion) after hepatic resection at the Eastern Hepatobiliary Surgery Hospital (Shanghai, China) from April 2005 and November 2010 using the Surveillance, Epidemiology, and End Results (SEER) database...
September 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/26579636/nomogram-for-preoperative-estimation-of-microvascular-invasion-risk-in-hepatitis-b-virus-related-hepatocellular-carcinoma-within-the-milan-criteria
#9
Zhengqing Lei, Jun Li, Dong Wu, Yong Xia, Qing Wang, Anfeng Si, Kui Wang, Xuying Wan, Wan Yee Lau, Mengchao Wu, Feng Shen
IMPORTANCE: The presence of microvascular invasion (MVI) decreases surgical outcomes of hepatocellular carcinoma (HCC). An accurate preoperative prediction of MVI can help surgeons to better choose surgical procedures, but accuracy is still difficult to achieve. OBJECTIVE: To develop a nomogram to predict MVI presence before liver resection for hepatitis B virus (HBV)-related HCC within the Milan criteria (solitary nodule ≤5 cm; ≤3 nodules, none >3 cm; and no macrovascular invasion)...
April 2016: JAMA Surgery
https://www.readbyqxmd.com/read/26382973/prognostic-nomograms-for-pre-and-postoperative-predictions-of-long-term-survival-for-patients-who-underwent-liver-resection-for%C3%A2-huge%C3%A2-hepatocellular-carcinoma
#10
Yuntong Li, Yong Xia, Jun Li, Dong Wu, Xuying Wan, Kui Wang, Mengchao Wu, Jingfeng Liu, Wan Yee Lau, Feng Shen
BACKGROUND: Liver resection is an effective treatment in select patients with huge hepatocellular carcinoma (HCC, diameter ≥10 cm). This study aimed to develop nomograms for pre- and postoperative predictions of overall survival (OS) for these patients. STUDY DESIGN: There were 464 consecutive patients who underwent liver resection for huge HCC at the Eastern Hepatobiliary Surgery Hospital (EHBH) between January 2008 and December 2009. They were collected and divided into a training cohort (n = 310) and an internal validation cohort (n = 154)...
November 2015: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/26136881/cidan-inhibits-liver-cancer-cell-growth-by-reducing-cox-2-and-vegf-expression-and-cell-cycle-arrest
#11
Nan Li, Donghai Zheng, Jie Xue, Weixing Guo, Jie Shi, Juxian Sun, Chongde Lu, Weida Zheng, Mengchao Wu, Shuqun Cheng
Cidan is a traditional Chinese medicine formula that has been used for >10 years as an antitumor drug. In the present study, the antitumor effect of cidan on hepatocellular carcinoma (HCC) and the underlying molecular mechanisms were investigated. A total of 372 patients with primary HCC, as confirmed by pathological examination in the Eastern Hepatobiliary Surgery Hospital and Beijing Oncology Hospital of Weida TCM, were prospectively enrolled in the study. In total, 92 patients were treated with cidan capsules for three months postoperatively, while 280 patients served as controls...
May 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26135698/nomograms-for-pre-and-postoperative-prediction-of-long-term-survival-for-patients-who-underwent-hepatectomy-for-multiple-hepatocellular-carcinomas
#12
Pinghua Yang, Jiliang Qiu, Jun Li, Dong Wu, Xuying Wan, Wan Yee Lau, Yunfei Yuan, Feng Shen
OBJECTIVES: To develop prognostic nomograms for patients undergoing hepatectomy for multiple hepatocellular carcinomas (mHCCs). BACKGROUND: The prognostic prediction after hepatectomy for mHCCs has not been well established. METHODS: A training cohort (n = 540) was analyzed to construct 2 nomograms based separately on data obtained before and after hepatectomy for mHCCs at the Eastern Hepatobiliary Surgery Hospital between 2000 and 2006. The internal and external validations were performed in 2 independent cohorts (n = 180 each) collected from the Eastern Hepatobiliary Surgery Hospital between 2007 and 2010 and the Sun Yat-Sen University between 2000 and 2007...
April 2016: Annals of Surgery
https://www.readbyqxmd.com/read/25973313/level-of-hepatitis-b-surface-antigen-might-serve-as-a-new-marker-to-predict-hepatocellular-carcinoma-recurrence-following-curative-resection-in-patients-with-low-viral-load
#13
Hua-Bang Zhou, Qiao-Mei Li, Zheng-Rong Zhong, Jing-Yi Hu, Xiao-Lan Jiang, Hao Wang, Hui Wang, Bing Yang, He-Ping Hu
To investigate the association between preoperative HBsAg (hepatitis B surface antigen) level and risk of HCC (hepatocellular carcinoma) recurrence following curative resection, we enrolled 826 HBV-related HCC patients who underwent curative resection and received long-term follow-up at the Eastern Hepatobiliary Surgery Hospital (Shanghai, China). Multivariate analyses showed that serum HBsAg ≥ 2000 S/CO, seropositive hepatitis B e antigen (HBeAg), γ-glutamyl transpeptidase > 61 U/L, prothrombin time > 13 s, multinodularity, lager tumor size, and major portal vein invasion were independently associated with a increased risk of HCC recurrence...
2015: American Journal of Cancer Research
https://www.readbyqxmd.com/read/25956404/adjuvant-transarterial-chemoembolization-following-liver-resection-for-intrahepatic-cholangiocarcinoma-based-on-survival-risk-stratification
#14
Jun Li, Qing Wang, Zhengqing Lei, Dong Wu, Anfeng Si, Kui Wang, Xuying Wan, Yizhou Wang, Zhenlin Yan, Yong Xia, Wan Yee Lau, Mengchao Wu, Feng Shen
BACKGROUND: The effectiveness of adjuvant transarterial chemoembolization (TACE) for intrahepatic cholangiocarcinoma (ICC) after hepatectomy remains unclear. This study was performed to identify ICC patients who would benefit from adjuvant TACE. PATIENTS AND METHODS: The study included 553 patients who underwent hepatectomy for ICC between January 2008 and February 2011 at the Eastern Hepatobiliary Surgery Hospital and who were treated with or without TACE (122 with TACE and 431 without TACE)...
June 2015: Oncologist
https://www.readbyqxmd.com/read/25890009/the-comparison-of-surgical-patients-with-primary-hepatic-squamous-cell-carcinoma-or-adenosquamous-carcinoma-and-surgical-patients-with-hepatocellular-carcinoma
#15
COMPARATIVE STUDY
Long Yan, Feng Xie, Cheng Yang, Lihan Yu, Tao Zheng, Jun Fu, Jiamei Yang
BACKGROUND: There are still several controversies and ambiguities in the aspects of primary hepatic squamous cell carcinoma and primary hepatic adenosquamous carcinoma. To further clarify the specific features of these two infrequent diseases and provide beneficial propose for clinical decision, we did this retrospective study. METHODS: We reviewed the clinical features and outcomes of three primary hepatic squamous cell carcinoma (SCC) patients and six primary hepatic adenosquamous carcinoma (ASC) patients from January 1998 to December 2011 in Eastern Hepatobiliary Surgery Hospital in China...
2015: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25801981/changes-in-serum-alpha-fetoprotein-in-patients-with-recurrent-hepatocellular-carcinoma-following-hepatectomy
#16
Guanghua Liu, Kui Wang, Jun Li, Yong Xia, Lihua Lu, Xuying Wan, Zhenlin Yan, Lehua Shi, Wan Yee Lau, Mengchao Wu, Feng Shen
BACKGROUND AND AIM: To study the change in serum alpha fetoprotein (AFP) of patients with recurrent hepatocellular carcinoma (HCC) after curative resection and to analyze its effect on the survival. METHODS: We prospectively collected 981 consecutive patients with post-resectional recurrent HCC between 2005 and 2010 at the Eastern Hepatobiliary Surgery Hospital. According to the change of AFP from the initial stage to recurrent stage, the patients were divided into stable-L (20 ng/mL to 20 ng/mL, n = 296), stable-M (20-400 ng/mL to 20-400 ng/mL, n = 102), stable-H (400 ng/mL to 400 ng/mL, n = 212), decreasing (n = 287), and increasing (n = 84) groups...
September 2015: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/25778037/the-comparison-of-surgical-patients-with-primary-hepatic-squamous-cell-carcinoma-or-adenosquamous-carcinoma-and-surgical-patients-with-hepatocellular-carcinoma
#17
Long Yan, Feng Xie, Cheng Yang, Lihan Yu, Tao Zheng, Jun Fu, Jiamei Yang
BACKGROUND: There are still several controversies and ambiguities in the aspects of primary hepatic squamous cell carcinoma and primary hepatic adenosquamous carcinoma. To further clarify the specific features of these two infrequent diseases and provide beneficial propose for clinical decision, we did this retrospective study. METHODS: We reviewed the clinical features and outcomes of three primary hepatic squamous cell carcinoma (SCC) patients and six primary hepatic adenosquamous carcinoma (ASC) patients from January 1998 to December 2011 in Eastern Hepatobiliary Surgery Hospital in China...
December 2015: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25216602/a-prognostic-scoring-system-for-patients-with-multiple-hepatocellular-carcinomas-treated-by-hepatectomy
#18
Pinghua Yang, Dong Wu, Yong Xia, Jun Li, Kui Wang, Zhenlin Yan, Lehua Shi, Wan Yee Lau, Mengchao Wu, Feng Shen
BACKGROUND: The selection criteria of hepatectomy for patients with multiple hepatocellular carcinomas (HCCs) remain controversial. METHODS: A scoring system based on preoperative data and independent predictors of overall survival (OS) was developed in a primary cohort of 510 patients who underwent hepatectomy for multiple HCCs from 1998 to 2006, and validated in 177 patients who were operated from 2006 to 2009 at the Eastern Hepatobiliary Surgery Hospital. RESULTS: In the NDR scoring system, tumor number (N) > 3, total tumor diameter (D) > 8 cm, and a ratio of largest/smallest diameter (R) > 6 were independent predictors of OS...
March 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/24901130/effect-evaluation-of-vascular-resection-for-patients-with-hilar-cholangiocarcinoma-original-data-and-meta-analysis
#19
Wenlong Yu, Minhua Shao, Zongting Gu, Song Shi, Ningjia Shen, Yongjie Zhang
BACKGROUND/AIMS: To evaluate the effect of vascular resection (VR) in surgical management of hilar cholangiocarcinoma (HCCA), this report did a clinical analysis and conducted a systematic review, combined other studies, based on meta-analysis. METHODOLOGY: Two hundred and thirty eight HCCA patients underwent hepatectomy in the Eastern Hepatobiliary Surgery Hospital. Binary logistic regression analysis was performed to investigate the potentially complications associated factors...
March 2014: Hepato-gastroenterology
https://www.readbyqxmd.com/read/24599477/a-nomogram-to-predict-long-term-survival-after-resection-for-intrahepatic-cholangiocarcinoma-an-eastern-and-western-experience
#20
MULTICENTER STUDY
Omar Hyder, Hugo Marques, Carlo Pulitano, J Wallis Marsh, Sorin Alexandrescu, Todd W Bauer, T Clark Gamblin, Georgios C Sotiropoulos, Andreas Paul, Eduardo Barroso, Bryan M Clary, Luca Aldrighetti, Cristina R Ferrone, Andrew X Zhu, Irinel Popescu, Jean-Francois Gigot, Gilles Mentha, Shen Feng, Timothy M Pawlik
IMPORTANCE: Intrahepatic cholangiocarcinoma (ICC) is a primary cancer of the liver that is increasing in incidence, and the prognostic factors associated with outcome after surgery remain poorly defined. OBJECTIVE: To combine clinicopathologic variables associated with overall survival after resection of ICC into a prediction nomogram. DESIGN, SETTING, AND PARTICIPANTS: We performed an international multicenter study of 514 patients who underwent resection for ICC at 13 major hepatobiliary centers in the United States, Europe, and Asia from May 1, 1990, through December 31, 2011...
May 2014: JAMA Surgery
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