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Spinal cord injuries

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https://www.readbyqxmd.com/read/27905554/increased-plasma-vegf-levels-following-ischemic-preconditioning-are-associated-with-downregulation-of-mirna-762-and-mir-3072-5p
#1
Koji Ueno, Makoto Samura, Tamami Nakamura, Yuya Tanaka, Yuriko Takeuchi, Daichi Kawamura, Masaya Takahashi, Tohru Hosoyama, Noriyasu Morikage, Kimikazu Hamano
Ischemic preconditioning (IPC) has protective effects against ischemia-perfusion injury of organs. In the present study, we investigated the associated mechanisms after performing remote IPC (rIPC) of lower limbs by clamping abdominal aorta in mice. Subsequent experiments showed decreased damage and paralysis of lower limbs following spinal cord injury (SCI). Concomitantly, plasma vascular endothelial growth factor (VEGF) levels were increased 24 h after rIPC compared with those in sham-operated animals. In subsequent microRNA analyses, thirteen microRNAs were downregulated in exosomes 24 h after rIPC...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905041/new-xymedon-analogues-for-stimulation-of-posttraumatic-regeneration-of-the-spinal-cord-in-rats
#2
T V Povysheva, V E Semenov, I V Galyametdinova, V S Reznik, K S Knni, P E Kolesnikov, Yu A Chelyshev
Effect of systemic administration of synthetic pyrimidine derivatives, xymedon and compounds 29D and 34D, was studied in rats with experimental dosed contusion spinal cord injury. Xymedon promoted recovery of motor function after injury. Compounds 29D and 34D more effectively restored the parameters of open-field and Rotarod tests in comparison with xymedon. Compound 29D more effectively than xymedon maintained the number of Olig2(+) oligodendrocytes in the corticospinal tract and NG2 cells in all investigated areas of the white matter...
December 1, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27904914/testicular-infarction-in-a-patient-with-spinal-cord-injury-with-epididymitis-a-case-report
#3
Po-Cheng Hsu, William J Huang, Shih-Fong Huang
: O-bjective: To describe a case of epididymitis-related testicular infarction in a patient with spinal cord injury. CASE REPORT: A 22-year-old man with a traumatic spinal cord injury (American Spinal Injury Association Impairment Scale A; neurological level, C4) developed epididymitis during hospitalization. He presented with spiking fever, autonomic dysreflexia, and increased spasticity. Physical examination revealed a rapidly progressive, firm swelling of the right hemiscrotum; however, the patient had no subjective complaint of pain owing to a loss of sensation...
November 30, 2016: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27904758/penetrating-thoracic-spinal-cord-injury-with-ice-pick-extending-into-the-aorta-a-technical-note-and-review-of-the-literature
#4
Rani Nasser, Jonathan Nakhla, Saadat Sharif, Merritt Kinon, Reza Yassari
BACKGROUND: Penetrating spinal cord injuries pose a great challenge to both patients and the treating physicians. Although the overall incidence of penetrating spinal cord injury is the highest in the military, the ubiquity of guns in our society continues to make penetrating spinal cord injury prevalent in the civilian population. These types of injuries are particularly complicated because, beyond the trauma to the neural elements and supporting structures, other organs can be affected and a team approach is required for successful treatment...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27904502/combination-of-methylprednisolone-and-rosiglitazone-promotes-recovery-of-neurological-function-after-spinal-cord-injury
#5
Xi-Gong Li, Xiang-Jin Lin, Jun-Hua Du, San-Zhong Xu, Xian-Feng Lou, Zhong Chen
Methylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-γ in the spinal cord. Methylprednisolone and rosiglitazone have been clinically used during the early stages of secondary spinal cord injury. Because of the complexity and diversity of the inflammatory process after spinal cord injury, a single drug cannot completely inhibit inflammation. Therefore, we assumed that a combination of methylprednisolone and rosiglitazone might promote recovery of neurological function after secondary spinal cord injury...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27904501/human-amniotic-epithelial-cells-combined-with-silk-fibroin-scaffold-in-the-repair-of-spinal-cord-injury
#6
Ting-Gang Wang, Jie Xu, Ai-Hua Zhu, Hua Lu, Zong-Ning Miao, Peng Zhao, Guo-Zhen Hui, Wei-Jiang Wu
Treatment and functional reconstruction after central nervous system injury is a major medical and social challenge. An increasing number of researchers are attempting to use neural stem cells combined with artificial scaffold materials, such as fibroin, for nerve repair. However, such approaches are challenged by ethical and practical issues. Amniotic tissue, a clinical waste product, is abundant, and amniotic epithelial cells are pluripotent, have low immunogenicity, and are not the subject of ethical debate...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27903223/releasing-of-herpes-simplex-virus-carrying-ngf-in-subarachnoid-space-promotes-the-functional-repair-in-spinal-cord-injured-rats
#7
Zhi-Wei Chen, Hang-Ping Wang, Feng-Mei Yuan, Xiao Zhang, Xiu-Juan Dong, Rui-Shen Xie, Chao Tian, Bing-Shen Li, Zhen-Wu Sun, Long-Hui Zhou, Jian Liu, Tinghua Wang
BACKGROUND: Spinal cord injury is a serious disease which can lead to bad consequence in patients. Gene therapies as an effective strategy, has been developed for the treatment of disease. OBJECTIVE: Here, we explored the effect of NGF release carried by HSV-1 in the injured spinal cord. METHODS: Transgenic recombinant containing NGF was constructed by using clone technology. NGF was firstly constructed into plasimid, then enveloped by HSV-1 vector...
November 20, 2016: Current Gene Therapy
https://www.readbyqxmd.com/read/27901476/the-change-of-hcn1-hcn2-mrna-expression-in-peripheral-nerve-after-chronic-constriction-injury-induced-neuropathy-followed-by-pulsed-electromagnetic-field-therapy
#8
Hui Liu, Jun Zhou, Lianbing Gu, Yunxia Zuo
Neuropathic pain is usually defined as a chronic pain state caused by peripheral or central nerve injury as a result of acute damage or systemic diseases. It remains a difficult disease to treat. Recent studies showed that the frequency of action potentials in nociceptive afferents is affected by the activity of hyperpolarization-activated cyclic nucleotide-gated cation channels (HCN) family. In the current study, we used a neuropathy rat model induced by chronic constriction injury (CCI) of sciatic nerve to evaluate the change of expression of HCN1/HCN2 mRNA in peripheral nerve and spinal cord...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901413/dose-response-outcomes-associated-with-different-forms-of-locomotor-training-in-persons-with-chronic-motor-incomplete-spinal-cord-injury
#9
Evan Blake Sandler, Kathryn E Roach, Edelle C Field-Fote
Outcomes of training are thought to be related to amount of training (training dose). While various approaches to locomotor training have been used to improve walking function in persons with spinal cord injury, little is known about the relationship between dose of locomotor training and walking outcomes. This secondary analysis aimed to identify the relationship between training dose and improvement in walking distance and speed associated with the largest randomized clinical trial to date of locomotor training in participants with chronic motor-incomplete spinal cord injury (MISCI)...
November 30, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27899230/experimental-zika-virus-infection-induces-spinal-cord-injury-and-encephalitis-in-newborn-swiss-mice
#10
Natália C C A Fernandes, Juliana S Nogueira, Rodrigo A Réssio, Cinthya S Cirqueira, Lidia M Kimura, Karolina R Fernandes, Mariana S Cunha, Renato P Souza, Juliana M Guerra
A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 in South and Central America, with neurological symptons including meningoencephalitis and Guillain-Barré syndrome in adults, besides an apparent increased incidence of microcephaly in infants born to infected mothers. It is becoming a necessity to have a trustworthy animal model to better understand ZIKV infection. In this study we used newborn white Swiss mice as a model to investigate the ZIKV strain recently isolated in Brazil. ZIKV was inoculated via intracerebral and subcutaneous routes and analysed through gross histopathology and immunohistochemistry...
November 26, 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27898492/growth-hormone-regulates-the-sensitization-of-developing-peripheral-nociceptors-during-cutaneous-inflammation
#11
Xiaohua Liu, Kathryn J Green, Zachary K Ford, Luis F Queme, Peilin Lu, Jessica L Ross, Frank B Lee, Aaron T Shank, Renita C Hudgins, Michael P Jankowski
Cutaneous inflammation alters the function of primary afferents and gene expression in the affected dorsal root ganglia (DRGs). However specific mechanisms of injury-induced peripheral afferent sensitization and behavioral hypersensitivity during development are not fully understood. Recent studies in children suggest a potential role for growth hormone (GH) in pain modulation. GH modulates homeostasis and tissue repair after injury, but how GH effects nociception in neonates is not known. To determine if GH played a role in modulating sensory neuron function and hyper-responsiveness during skin inflammation in young mice, we examined behavioral hypersensitivity and the response properties of cutaneous afferents using an ex vivo hairy skin-saphenous nerve-dorsal root ganglion (DRG)-spinal cord preparation...
November 18, 2016: Pain
https://www.readbyqxmd.com/read/27898477/costs-and-length-of-stay-for-the-acute-care-of-patients-with-motor-complete-spinal-cord-injury-following-cervical-trauma-the-impact-of-early-transfer-to-specialized-acute-sci-center
#12
Andréane Richard-Denis, Debbie Ehrmann Feldman, Cynthia Thompson, Étienne Bourassa-Moreau, Jean-Marc Mac-Thiong
OBJECTIVE: Acute spinal cord injury (SCI) centers aim to optimize outcome following SCI. However, there is no timeframe to transfer patients from regional to SCI centers in order to promote cost-efficiency of acute care. Our objective was to compare costs and length of stay (LOS) following early and late transfer to the SCI center. DESIGN: A retrospective cohort study involving 116 individuals was conducted. Group 1 (n = 87) was managed in an SCI center promptly after the trauma, whereas group 2 (n = 29) was transferred to the SCI center only after surgery...
November 24, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27898179/temporal-kinetics-of-cd8-cd28-and-cd8-cd28-t-lymphocytes-in-the-injured-rat-spinal-cord
#13
Yan Wu, Yu-Hong Lin, Ling-Ling Shi, Zong-Feng Yao, Xiu-Mei Xie, Zheng-Song Jiang, Jie Tang, Jian-Guo Hu, He-Zuo Lü
This study aims to explore the temporal changes of cytotoxic CD8(+) CD28(+) and regulatory CD8(+) CD28(-) T-cell subsets in the lesion microenvironment after spinal cord injury (SCI) in rats, by combination of immunohistochemistry (IHC) and flow cytometry (FCM). In the sham-opened spinal cord, few CD8(+) T cells were found. After SCI, the CD8(+) T cells were detected at one day post-injury (dpi), then markedly increased and were significantly higher at 3, 7, and 14 dpi compared with one dpi (p < 0.01), the highest being seven dpi...
November 29, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27897188/community-participation-for-individuals-with-spinal-cord-injury-living-in-queensland-australia
#14
J J Carr, M B Kendall, D I Amsters, K J Pershouse, P Kuipers, P Buettner, R N Barker
STUDY DESIGN: Sequential mixed method design. OBJECTIVES: Determine factors associated with community participation for individuals with spinal cord injury (SCI). SETTING: Queensland, Australia. METHODS: Phase I consisted of a quantitative telephone survey of 270 people who had sustained a SCI within the past 50 years. To verify and interpret survey findings, Phase II involved a qualitative investigation. One focus group, one dyadic and one in-depth interview were conducted with a separate sample of eight people who had sustained a SCI within the past 50 years...
November 29, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27897187/a-latent-structural-equation-model-of-protective-behaviors-and-pressure-ulcer-outcomes-among-people-living-with-spinal-cord-injury
#15
C Li, N D DiPiro, J Krause
STUDY DESIGN: Cross-sectional. OBJECTIVE: To develop a latent structural model to demonstrate the relationship between factor structures of protective health behaviors and pressure ulcer (PrU) outcomes among participants with spinal cord injury (SCI). SETTING: Data were collected at a large specialty hospital and analyzed at a medical university in the Southeastern USA. METHODS: A total of 1871 participants with traumatic SCI of at least 1 year duration were included...
November 29, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27897186/managing-pain-and-fatigue-in-people-with-spinal-cord-injury-a-randomized-controlled-trial-feasibility-study-examining-the-efficacy-of-massage-therapy
#16
J Lovas, Y Tran, J Middleton, R Bartrop, N Moore, A Craig
STUDY DESIGN: A randomized controlled trial (RCT). OBJECTIVES: To determine the efficacy of massage therapy (MT) as a treatment that could be implemented to reduce pain and fatigue in people with chronic spinal cord injury (SCI). SETTING: Laboratory setting in Sydney, Australia. METHODS: Participants included 40 people with SCI living in the community who were randomly assigned into one of two RCT arms: MT (Swedish massage to upper body) or an active concurrent control (guided imagery (GI) relaxation)...
November 29, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27897185/effect-of-imidafenacin-on-the-urodynamic-parameters-of-patients-with-indwelling-bladder-catheters-due-to-spinal-cord-injury
#17
H Sugiyama, O Uemura, T Mori, N Okisio, K Unai, M Liu
STUDY DESIGN: A retrospective study. OBJECTIVES: To investigate the effect of imidafenacin on the urodynamic parameters of patients with indwelling bladder catheters due to spinal cord injury (SCI). SETTING: Spinal center (Tokyo, Japan). METHODS: Imidafenacin was prescribed to 34 patients with SCI who had a low cystometric volume and/or detrusor compliance according to a urodynamic study. A low cystometric volume and detrusor compliance were defined as <200 ml and <20 ml cm(-1) H2O, respectively...
November 29, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27897184/an-evaluation-of-the-international-standards-to-document-remaining-autonomic-function-after-spinal-cord-injury-input-from-the-international-community
#18
A M Round, S E Park, K Walden, V K Noonan, A F Townson, A V Krassioukov
STUDY DESIGN: Interactive workshops with a presurvey-postsurvey. OBJECTIVES: To describe a series of workshops held at international meetings to inform the spinal cord injury (SCI) community about the International Standards to Document Remaining Autonomic Function after Spinal Cord Injury (ISAFSCI) and to obtain feedback on both the workshop and the ISAFSCI assessment. SETTING: Three international conferences of SCI practitioners in Toronto, Las Vegas and Vancouver held between 2012 and 2013...
November 29, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27896922/-epigallocatechin-3-gallate-antihyperalgesic-effect-associates-with-reduced-cx3cl1-chemokine-expression-in-spinal-cord
#19
Marc Bosch-Mola, Judit Homs, Beltrán Álvarez-Pérez, Teresa Puig, Francisco Reina, Enrique Verdú, Pere Boadas-Vaello
(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the neuropathic pain alleviation in animal models. Because chemokine fractalkine (CX3CL1) has been suggested as an important signal during neuropathic pain development, this study aimed to investigate whether CX3CL1 expression may be modulated by EGCG treatment reducing hyperalgesia in chronic constriction injured mice. To this end, Balb/c mice were subjected to a chronic constriction injury of sciatic nerve (CCI) and treated with EGCG or vehicle once a day during the first week following surgery...
November 29, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27896143/new-avenues-for-reducing-intensive-care-needs-in-patients-with-chronic-spinal-cord-injury
#20
EDITORIAL
Pierre A Guertin
Relatively soon after their accident, patients suffering a spinal cord injury (SCI) begin generally experiencing the development of significant, often life-threatening secondary complications. Many of which are associated with chronic physical inactivity-related immune function problems and increasing susceptibility to infection that repeatedly requires intensive care treatment. Therapies capable of repairing the spinal cord or restoring ambulation would normally prevent many of these problems but, as of now, there is no cure for SCI...
November 4, 2016: World Journal of Critical Care Medicine
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