Gui-Qiang Fu, Yang-Yang Wang, Yao-Mei Xu, Ming-Ming Bian, Lin Zhang, Hua-Zheng Yan, Jian-Xiong Gao, Jing-Lu Li, Yu-Qing Chen, Nan Zhang, Shu-Qin Ding, Rui Wang, Jiang-Yan Li, Jian-Guo Hu, He-Zuo Lü
Inflammation is one of the key injury factors for spinal cord injury (SCI). Exosomes (Exos) derived from M2 macrophages have been shown to inhibit inflammation and be beneficial in SCI animal models. However, lacking targetability restricts their application prospects. Considering that chemokine receptors increase dramatically after SCI, viral macrophage inflammatory protein II (vMIP-II) is a broad-spectrum chemokine receptor binding peptide, and lysosomal associated membrane protein 2b (Lamp2b) is the key membrane component of Exos, we speculated that vMIP-II-Lamp2b gene-modified M2 macrophage-derived Exos (vMIP-II-Lamp2b-M2-Exo) not only have anti-inflammatory properties, but also can target the injured area by vMIP-II...
April 18, 2024: Experimental Neurology