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https://www.readbyqxmd.com/read/29029217/high-levels-of-susceptibility-to-new-and-older-antibiotics-in-neisseria-gonorrhoeae-isolates-from-saskatchewan-2003-15-time-to-consider-point-of-care-or-molecular-testing-for-precision-treatment
#1
Sidharath D Thakur, Paul N Levett, Gregory B Horsman, Jo-Anne R Dillon
Objectives: The antimicrobial susceptibility of Neisseria gonorrhoeae isolates from Saskatchewan was determined retrospectively (2003-15) to ascertain temporal trends to both current and older antimicrobials used for treatment. Method: The agar dilution method was used to test the antimicrobial susceptibilities of 685 isolates to seven antibiotics. Results: Over the period, only three (0.4%) gonococcal isolates had reduced susceptibility to cefixime and/or ceftriaxone...
September 27, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29029084/penicillin-binding-protein-encoded-by-pbp4-is-involved-in-mediating-copper-stress-in-listeria-monocytogenes
#2
Cameron Parsons, Ben Costolo, Phillip Brown, Sophia Kathariou
Listeria monocytogenes raises major food safety and public health concerns due its potential for severe foodborne disease and persistent colonization of food processing facilities. Copper is often employed to control pathogens in agriculture and is increasingly used in healthcare facilities, but mechanisms mediating tolerance of L. monocytogenes to copper remain poorly understood. A mariner-based mutant library of L. monocytogenes 2011L-2858, implicated in the 2011 listeriosis outbreak via whole cantaloupe, was screened for growth at sublethal levels of copper yielding mutant G2B4 with decreased copper tolerance...
October 4, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29028329/sponge-spray-reaching-new-dimensions-of-direct-sampling-and-analysis-by-ms
#3
Max Hecht, Hanno Evard, Kalev Takkis, Ruta Veigure, Rudolf Aro, Runno Lohmus, Koit Herodes, Ivo Leito, Karin Kipper
Sample preparation for the analysis of clinical samples with the mass spectrometer (MS) can be extensive and expensive. Simplifying and speeding up the process would be very beneficial. This paper reports sponge spray - a novel sampling and direct MS analysis approach - attempting exactly that. It enables direct analysis without any sample preparation from dried blood, plasma and urine. The tip of a volumetric absorptive microsampling device is used to collect an exact amount of sample and from that same tip an electrospray can be directed into a mass spectrometer...
October 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29028276/enhancing-antibiotic-stewardship-by-tackling-spurious-penicillin-allergy
#4
Mamidipudi Thirumala Krishna, Aarnoud P Huissoon, Mark Li, Alex Richter, Devadas Ganesh Pillay, Dhinakaran Sambanthan, Sumanth C Raman, Shuaib Nasser, Siraj A Misbah
Approximately 90-99% of patients with a label of penicillin allergy (PenA) are not allergic when comprehensively investigated. An inaccurate label of PenA has major public health implications - longer hospital stay, more frequent hospital admissions, greater use of fluoroquinolones, glycopeptides, cephalosporins and other expensive antibiotics resulting in significantly higher costs to the health service and predisposing to Clostridium difficile, meticillin-resistant Staphylococcus aureus infections and vancomycin resistant enterococcus...
October 13, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29027076/assessing-the-stability-in-dry-mycelial-fertilizer-of-penicillium-chrysogenum-as-soil-amendment-via-fluorescence-excitation-emission-matrix-spectra-organic-matter-s-transformation-and-maturity
#5
Bing Wang, Chen Cai, Guomin Li, Huiling Liu
Utilization as dry mycelial fertilizer (DMF) produced from penicillin fermentation fungi mycelium (PFFM) with an acid-heating pretreatment is a potential way. To study the transformation and stability of water-extractable organic matter in DMF-amended soil via fluorescence regional integration (FRI) of fluorescence excitation-emission matrix (EEM), a soil experiment in pot was carried out. The results showed that residual penicillin (about 32 mg/kg) was almost degraded in the first 5 days, indicating that the drug pollution was in control...
October 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29026622/lower-extremity-mycotic-aneurysm-in-a-patient-with-listeria-monocytogenes-associated-prosthetic-valve-endocarditis
#6
Elham Rahmati, P Jan Geiseler, Rosemary C She
Introduction.Listeria monocytogenes is a rare etiology of infectious endocarditis with only 30 cases of prosthetic valve and about twice as many native valve infections described in the literature. We describe an unusual presentation of an endovascular embolic phenomenon with associated lower extremity mycotic aneurysm due to Listeria monocytogenes prosthetic aortic valve and aortic endograft infection. Case presentation. This is a case of an elderly gentleman with prior history of bioprosthetic aortic valve placement and aortic arch repair who was admitted with several weeks of constitutional symptoms and left lower leg pain...
May 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026593/antibiotic-resistance-and-gyra-mutation-affect-the-efficacy-of-10-day-sitafloxacin-metronidazole-esomeprazole-therapy-for-helicobacter-pylori-in-penicillin-allergic-patients
#7
Hideki Mori, Hidekazu Suzuki, Juntaro Matsuzaki, Tatsuhiro Masaoka, Takanori Kanai
BACKGROUND AND AIM: Helicobacter pylori (H. pylori) eradication regimen has not been standardized for patients with penicillin allergy. We investigated the association between the efficacy of a 10-day sitafloxacin, metronidazole, and esomeprazole triple regimen and antibiotic resistance, in patients with penicillin allergy. METHODS: Penicillin-allergic patients infected with H. pylori were enrolled between March 2014 and November 2015. The minimum inhibitory concentrations (MICs) of sitafloxacin and metronidazole, and the gyrA mutation status of the H...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29023263/multimodal-imaging-adds-new-insights-into-acute-syphilitic-posterior-placoid-chorioretinitis
#8
Edmund Tsui, Orly Gal-Or, Quraish Ghadiali, K Bailey Freund
PURPOSE: Acute syphilitic posterior placoid chorioretinitis (ASPPC) is an uncommon manifestation of ocular syphilis with distinct clinical features. We describe new multimodal imaging findings in a patient with ASPPC. METHODS: Observational case report with multimodal imaging. RESULTS: A 44-year-old woman presented with 5 days of decreased vision in her right eye. Visual acuity was counting fingers in her right eye and 20/20 in her left eye...
October 11, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29023054/genetic-characterization-antimicrobial-resistance-patterns-and-virulence-determinants-of-staphylococcus-aureus-isolated-form-bovine-mastitis
#9
Amal Awad, Hazem Ramadan, Sherif Nasr, Ahmed Ateya, Samar Atwa
BACKGROUND AND OBJECTIVE: Staphylococcus aureus is commonly associated with mastitis in dairy herds with potential public health implications. This study was conducted to investigate the existence of S. aureus in mastitic milk and to determine the antimicrobial resistance profiles of the isolated strains as well as the resistance and virulence associated genes. MATERIALS AND METHODS: Two hundred quarter milk samples were collected from 3 dairy farms at Dakahliya (n = 2) and Damietta (n = 1) Governorates, Egypt from September to December 2016...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022569/syphilis
#10
REVIEW
Rosanna W Peeling, David Mabey, Mary L Kamb, Xiang-Sheng Chen, Justin D Radolf, Adele S Benzaken
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. T. pallidum is renowned for its invasiveness and immune-evasiveness; its clinical manifestations result from local inflammatory responses to replicating spirochaetes and often imitate those of other diseases. The spirochaete has a long latent period during which individuals have no signs or symptoms but can remain infectious. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries...
October 12, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29022402/antibiotics-exposure-and-risk-of-inflammatory-bowel-disease-a-systematic-review
#11
Nikoletta A Theochari, Anastasios Stefanopoulos, Konstantinos S Mylonas, Konstantinos P Economopoulos
AIM: The aim of this study was to critically assess all available evidence suggesting an association between antibiotic exposure and new onset of inflammatory bowel disease (IBD). MATERIALS AND METHODS: This systematic review was conducted according to the PRISMA statement and eligible studies were identified through search of PubMed, Embase and the Cochrane Library. Data on patient demographics, antibiotic exposure and confounding factors were analyzed. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of eligible studies...
October 12, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29021974/role-of-low-molecular-mass-penicillin-binding-proteins-nagz-and-ampr-in-ampc-%C3%AE-lactamase-regulation-of-yersinia-enterocolitica
#12
Chang Liu, Chuchu Li, Yuhuang Chen, Huijing Hao, Junrong Liang, Ran Duan, Zhaoke Guo, Jing Zhang, Zhongzhi Zhao, Huaiqi Jing, Xin Wang, Shihe Shao
Yersinia enterocolitica encodes a chromosomal AmpC β-lactamase under the regulation of the classical ampR-ampC system. To obtain a further understanding to the role of low-molecular-mass penicillin-binding proteins (LMM PBPs) including PBP4, PBP5, PBP6, and PBP7, as well as NagZ and AmpR in ampC regulation of Y. enterocolitica, series of single/multiple mutant strains were systematically constructed and the ampC expression levels were determined by luxCDABE reporter system, reverse transcription-PCR (RT-PCR) and β-lactamase activity test...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29021946/predictors-of-pneumococcal-carriage-and-the-effect-of-the-13-valent-pneumococcal-conjugate-vaccination-in-the-western-australian-aboriginal-population
#13
Deirdre A Collins, Anke Hoskins, Thomas Snelling, Kalpani Senasinghe, Jacinta Bowman, Natalie A Stemberger, Amanda J Leach, Deborah Lehmann
BACKGROUND: The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced to prevent invasive pneumococcal disease (IPD) in Western Australian (WA) Aboriginal people in 2001. PCV13 replaced PCV7 in July 2011, covering six additional pneumococcal serotypes; however, IPD rates remained high in Aboriginal people in WA. Upper respiratory tract pneumococcal carriage can precede IPD, and PCVs alter serotype distribution. METHODS: To assess the impact of PCV13 introduction, identify emerging serotypes, and assess risk factors for carriage, nasopharyngeal swabs and information on demographic characteristics, health, medication and living conditions from Aboriginal children and adults across WA from August 2008 to November 2014 were collected...
2017: Pneumonia
https://www.readbyqxmd.com/read/29020920/first-identification-of-gordonia-sputi-in-a-post-traumatic-endophthalmitis-patient-a-case-report-and-literatures-review
#14
Wei Fang, Jiuke Li, Hu-Shan Cui, Xiaohong Jin, Jing Zhai, Yuanmin Dai, Yumin Li
BACKGROUND: We present a case of post-traumatic endophthalmitis with relatively good prognosis caused by Gordonia sputi, which, to our knowledge is the first case in the literature. CASE PRESENTATION: A 24 year old man, who underwent an intraocular foreign body extraction half a month before presentation in the left eye, was referred to us complaining of blurred vision and slight pain for 5 days. His first presentation showed moderate intracameral and intravitreous purulent inflammation with a best corrected vision of counting fingers...
October 11, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29020886/comparison-of-culture-methodology-for-the-detection-of-methicillin-resistant-staphylococcus-pseudintermedius-in-clinical-specimens-collected-from-dogs
#15
Matthew E Saab, C Anne Muckle, Henrik Stryhn, J Trenton McClure
Methicillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as a major pathogen in dogs and has been implicated as a hospital-acquired pathogen in veterinary hospitals. We attempted to determine if selective culture methods will detect more MRSP when compared to the traditional culture methods in clinical samples from dogs in Atlantic Canada with a high risk for MRSP infection. Each sample was tested using 4 culture methods: traditional culture; mannitol salt agar with 2 μg/mL of oxacillin (MSAox); enrichment broth (EB) with MSAox; and EB with traditional culture...
October 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29020531/mechanisms-of-antibiotic-resistance-in-bacteria-mediated-by-silver-nanoparticles
#16
Chitrada Kaweeteerawat, Preeyawis Na Ubol, Sanirat Sangmuang, Sasitorn Aueviriyavit, Rawiwan Maniratanachote
Silver nanoparticles (AgNPs) are widely used in industry, consumer products, and medical appliances due to their efficient antimicrobial properties. However, information on environmental toxicity and bacterial impact of these particles is not completely elucidated. Results showed that AgNPs produced growth inhibition and oxidative stress in bacteria Escherichia coli (gram negative) and Staphylococcus aureus (gram positive), with half-maximal inhibitory concentrations (IC50) of 12 and 7 mg/L, respectively. Surprisingly, bacteria pre-exposed to sublethal dose of AgNPs exhibited increased resistance toward antibiotics (ampicillin and Pen-Strep) with IC50 elevated by 3-13-fold...
October 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29020360/epidemiology-clinical-features-and-outcome-of-infective-endocarditis-due-to-abiotrophia-spp-and-granulicatella-spp-report-of-76-cases-2000-2015
#17
Adrián Téllez, Juan Ambrosioni, Jaume Llopis, Juan M Pericàs, Carles Falces, Manel Almela, Cristina Garcia de la Mària, Marta Hernandez-Meneses, Bàrbara Vidal, Elena Sandoval, Eduard Quintana, David Fuster, José M Tolosana, Francesc Marco, Asunción Moreno, José M Miro
Background: Infective endocarditis (IE) caused by Abiotrophia (ABI) and Granulicatella (GRA) is poorly studied. This work aims to describe and compare the main features of ABI and GRA IE. Methods: We performed a retrospective study of 12 IE institutional cases of GRA or ABI and of 64 cases published in the literature (overall, 38 ABI and 38 GRA IE cases). Results: ABI/GRA IE represented 1.51% of IE cases in our institution between 2000-2015, compared to 0...
August 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020150/a-multicenter-study-evaluating-ceftriaxone-and-benzathine-penicillin-g-as-treatment-agents-for-early-syphilis-in-jiangsu-china
#18
Yuping Cao, Xiaohong Su, Qianqiu Wang, Huazhong Xue, Xiaofeng Zhu, Chuanfu Zhang, Juan Jiang, Shuzhen Qi, Xiangdong Gong, Xiaofang Zhu, Min Pan, Hong Ren, Wenlong Hu, Zhiping Wei, Meihua Tian, Weida Liu
Background: The aim of this study was to assess the efficacy of ceftriaxone and benzathine penicillin G (BPG) in nonpregnant, immunocompetent adults with early syphilis because there is a lack of clinical evidence supporting ceftriaxone as an alternative treatment for early syphilis without an human immunodeficiency virus coinfection. Methods: A randomized, open-label controlled study evaluating the efficacy of ceftriaxone and BPG was conducted in 4 hospitals in Jiangsu Province...
July 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29017833/cross-reactivity-in-%C3%AE-lactam-allergy
#19
Robert J Zagursky, Michael E Pichichero
β-Lactam drugs (penicillins, amoxicillin, and cephalosporins) account for 42.6% of all severe drug-induced anaphylaxis. In this review, we focus on clinically significant immunologic cross-reactivity in patients with confirmed penicillin allergy to cephalosporins, and the structural involvement of the R1 and R2 chemical side chains of the cephalosporins causing IgE-mediated cross-reactivity with penicillin and other cephalosporins. Skin tests predict IgE-mediated reactions and showed cross-reactivity between penicillins and early generation cephalosporins that shared side chains, but confirmatory challenge data are lacking...
October 7, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29017750/trends-and-relationship-between-antimicrobial-resistance-and-antibiotic-use-in-xinjiang-uyghur-autonomous-region-china-based-on-a-3-year-surveillance-data-2014-2016
#20
Haishaerjiang Wushouer, Zhao-Xia Zhang, Jian-Hua Wang, Ping Ji, Qing-Fang Zhu, Renagu Aishan, Lu-Wen Shi
PURPOSES: The objective of the study was to identify the trends and relations between antimicrobial resistance (AMR) and antibiotic use in the Xinjiang Uyghur Autonomous Region in Western China from 2014 to 2016. METHODS: A retrospective, descriptive analysis of AMR prevalence, and trends and relations between AMR and antibiotic use during the 3-year period was performed. RESULTS: Third-generation cephalosporin-resistant Escherichia coli was the most prevalent resistant pathogen in terms of both resistance density and resistance proportion...
October 7, 2017: Journal of Infection and Public Health
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