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https://www.readbyqxmd.com/read/28821610/a-screen-for-kinase-inhibitors-identifies-antimicrobial-imidazopyridine-aminofurazans-as-specific-inhibitors-of-the-listeria-monocytogenes-pasta-kinase-prka
#1
Adam J Schaenzer, Nathan Wlodarchak, David H Drewry, William J Zuercher, Warren E Rose, Rob Striker, John-Demian Sauer
Bacterial signaling systems such as protein kinases and quorum sensing have become increasingly attractive targets for the development of novel antimicrobial agents in a time of rising antibiotic resistance. The family of bacterial Penicillin-binding-protein And Serine/Threonine kinase-Associated (PASTA) kinases is of particular interest due to the role of these kinases in regulating resistance to β-lactam antibiotics. As such, small-molecule kinase inhibitors that target PASTA kinases may prove beneficial as treatments adjunctive to β-lactam therapy...
August 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28821219/early-congenital-syphilis-recognising-symptoms-of-an-increasingly-prevalent-disease
#2
Nupur U Patel, Elias Oussedik, Erin T Landis, Lindsay C Strowd
BACKGROUND: Congenital syphilis (CS) is an infectious disease resulting from transplacental transmission of Treponema pallidum spirochetes from an infected mother to fetus during pregnancy. While uncommon, CS has shown an increased incidence in Canada and the United States since 2001 and 2012, respectively. CASE REPORT: We present the case of a 5-week-old female infant with blistering rash on the palms and soles. The infant displayed decreased movement of the left upper extremity, clinically consistent with Parrot pseudoparalysis...
August 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28820128/molecular-antimicrobial-resistance-surveillance-for-neisseria-gonorrhoeae-northern-territory-australia
#3
David M Whiley, Ella Trembizki, Cameron Buckley, Kevin Freeman, Robert W Baird, Miles Beaman, Marcus Chen, Basil Donovan, Ratan L Kundu, Christopher K Fairley, Rebecca Guy, Tiffany Hogan, John M Kaldor, Mahdad Karimi, Athena Limnios, David G Regan, Nathan Ryder, Jiunn-Yih Su, James Ward, Monica M Lahra
Neisseria gonorrhoeae antimicrobial resistance (AMR) is a globally recognized health threat; new strategies are needed to enhance AMR surveillance. The Northern Territory of Australia is unique in that 2 different first-line therapies, based primarily on geographic location, are used for gonorrhea treatment. We tested 1,629 N. gonorrhoeae nucleic acid amplification test-positive clinical samples, collected from regions where ceftriaxone plus azithromycin or amoxicillin plus azithromycin are recommended first-line treatments, by using 8 N...
September 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28819087/investigation-and-characterization-of-%C3%AE-lactam-resistance-in-escherichia-coli-strains-isolated-from-bamboo-rats-rhizomys-sinensis-in-zhejiang-province-china
#4
Hui Zhang, Kun Li, Yajing Wang, Mujeeb Ur Rehman, Yijiang Liu, Junjie Jin, Junping Peng, Fazul Nabi, Khalid Mehmood, Houqiang Luo, Jiaxiang Wang
This study was undertaken to investigate drug resistance in Escherichia coli (E. coli) strains isolated from bamboo rats in Zhejiang province of China. One hundred and fifty-four E. coli strains were isolated from dead bamboo rats. Polymerase chain reaction (PCR) was used to detect the representative genes encoding resistance to commonly used β-lactam antibiotics. Highest resistance was observed for cefradine (24.03%), followed by penicillin (20.78%) and ceftazidime (20.13%). The isolation rates of β-lactam resistance genes were 53...
August 17, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28818574/antimicrobial-resistance-determinants-and-susceptibility-profiles-of-pneumococcal-isolates-recovered-in-trinidad-and-tobago
#5
Paulina A Hawkins, Patrick E Akpaka, Michele Nurse-Lucas, Rebecca Gladstone, Stephen D Bentley, Robert F Breiman, Lesley McGee, William H Swanston
INTRODUCTION: In Latin America and the Caribbean, pneumococcal infections were estimated to account for 12,000-18,000 deaths, 327,000 cases of pneumonia, 4,000 cases of meningitis and 1,229 cases of sepsis each year in children under five years old. Resistance of pneumococci to antimicrobial agents has evolved into a worldwide health problem in the last few decades. OBJECTIVE: The aim of this study was to determine the antimicrobial susceptibility profiles of 98 pneumococcal isolates collected in Trinidad and Tobago and associated genetic determinants...
August 14, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28818544/trends-in-antimicrobial-resistance-in-bloodstream-infection-isolates-at-a-large-urban-hospital-in-malawi-1998-2016-a-surveillance-study
#6
Patrick Musicha, Jennifer E Cornick, Naor Bar-Zeev, Neil French, Clemens Masesa, Brigitte Denis, Neil Kennedy, Jane Mallewa, Melita A Gordon, Chisomo L Msefula, Robert S Heyderman, Dean B Everett, Nicholas A Feasey
BACKGROUND: Bacterial bloodstream infection is a common cause of morbidity and mortality in sub-Saharan Africa, yet few facilities are able to maintain long-term surveillance. The Malawi-Liverpool-Wellcome Trust Clinical Research Programme has done sentinel surveillance of bacteraemia since 1998. We report long-term trends in bloodstream infection and antimicrobial resistance from this surveillance. METHODS: In this surveillance study, we analysed blood cultures that were routinely taken from adult and paediatric patients with fever or suspicion of sepsis admitted to Queen Elizabeth Central Hospital, Blantyre, Malawi from 1998 to 2016...
August 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28817816/exosomes-derived-from-human-bone-marrow-mesenchymal-stem-cells-promote-tumor-growth-through-hedgehog-signaling-pathway
#7
Jin Qi, Yali Zhou, Zuoyi Jiao, Xu Wang, Yang Zhao, Yangbin Li, Huijuan Chen, Luxi Yang, Hongwen Zhu, Yumin Li
BACKGROUND/AIMS: Mesenchymal stem/stromal cells (MSCs) are known to home to sites of tumor microenvironments where they participate in the formation of the tumor microenvironment and to interplay with tumor cells. However, the potential functional effects of MSCs on tumor cell growth are controversial. Here, we, from the view of bone marrow MSC-derived exosomes, study the molecular mechanism of MSCs on the growth of human osteosarcoma and human gastric cancer cells. METHODS: MSCs derived from human bone marrow (hBMSCs) were isolated and cultured in complete DMEM/F12 supplemented with 10% exosome-depleted fetal bovine serum and 1% penicillin-streptomycin, cell culture supernatants containing exosomes were harvested and exosome purification was performed by ultracentrifugation...
August 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28817704/analysis-of-multidrug-resistant-group-b-streptococci-with-reduced-penicillin-susceptibility-forming-small-less-hemolytic-colonies
#8
Hirotsugu Banno, Kouji Kimura, Yosuke Tanaka, Tsuyoshi Sekizuka, Makoto Kuroda, Wanchun Jin, Jun-Ichi Wachino, Keiko Yamada, Keigo Shibayama, Yoshichika Arakawa
Group B streptococci (GBS; Streptococcus agalactiae) are the leading cause of neonatal invasive diseases and are also important pathogens for elderly adults. Until now, nearly all GBS with reduced penicillin susceptibility (PRGBS) have shown β-hemolytic activity and grow on sheep blood agar. However, we have previously reported three PRGBS clinical isolates harboring a CylK deletion that form small less hemolytic colonies. In this study, we examined the causes of small, less hemolytic colony formation in these clinical isolates...
2017: PloS One
https://www.readbyqxmd.com/read/28817271/poly-2-oxazoline-antibiotic-conjugates-with-penicillins
#9
Martin Schmidt, Livia K Bast, Franziska Lanfer, Lena Richter, Elisabeth Hennes, Rana Seymen, Christian Krumm, Joerg C Tiller
Conjugation of antibiotics with polymers is rarely done, but might be a promising alternative to low molecular weight derivatization. The two penicillins PenG and PenV were attached to the end groups of different water-soluble poly(2-oxazoline)s (POx) via their carboxylic acid function. This ester group was shown to be more stable against hydrolysis than the β-lactam ring of the penicillins. The conjugates are still antimicrobially active and up to 20 times more stable against penicillinase catalyzed hydrolysis...
August 17, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28816862/unilateral-optic-neuritis-and-central-retinal-vasculitis-due-to-ocular-syphilis
#10
Murtaza S Khan, Dulanji K Kuruppu, Tanav A Popli, Ramana S Moorthy, Devin D Mackay
PURPOSE: Report a case of concurrent unilateral optic neuritis and central retinal artery occlusion as the presenting signs of syphilis. METHODS: A case report of a 22-year-old man with progressive unilateral vision loss. RESULTS: With no known previous history of syphilis, genital lesions, or other extraocular manifestations, the patient presented with pain with eye movements and decreased color vision. His vision dramatically worsened after a course of oral steroids...
August 14, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28816431/carbon-nanotubes-arranged-as-smart-interfaces-in-lipid-langmuir-blodgett-films-enhancing-the-enzymatic-properties-of-penicillinase-for-biosensing-applications
#11
Fabio Scholl, Paulo Morais, Rayla Gabriel, Michael J Schöning, Jose Roberto Siqueira, Luciano Caseli
In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir-Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air-water interface was investigated by surface pressure-area isotherms, vibrational spectroscopy and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28814358/frequency-of-selective-immediate-responders-to-aminopenicillins-and-cephalosporins-in-turkish-children
#12
Emine Dibek Misirlioglu, Hakan Guvenir, Muge Toyran, Emine Vezir, Murat Capanoglu, Ersoy Civelek, Betul Buyuktiryaki, Tayfur Ginis, Can Naci Kocabas
BACKGROUND: Beta-lactam antibiotics (BLA) are the most commonly prescribed antibiotics and are responsible for the majority of immediate hypersensitivity reactions to drugs in children. Cross-reactivity is important in hypersensitivity to BLAs because these drugs all share a common beta-lactam structure and some share similar side chains. OBJECTIVE: The aim of this study was to evaluate the clinical characteristics of patients who are diagnosed with immediate-type BLA hypersensitivity and frequency of patients with side chain hypersensitivity, "selective responders...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28813477/colonization-prevalence-and-antibiotic-susceptibility-of-group-b-streptococcus-in-pregnant-women-over-a-6-year-period-in-dongguan-china
#13
Wenjing Ji, Lihua Zhang, Zhusheng Guo, Shujin Xie, Weiqing Yang, Junjian Chen, Jiamin Wang, Zhiqin Cheng, Xin Wang, Xuehai Zhu, Jianwen Wang, Haiqing Wang, Juan Huang, Ning Liang, David J McIver
This study investigated the prevalence of recto-vaginal Group B Streptococcus (GBS) colonization, serotype distribution, and antimicrobial susceptibility patterns among pregnant women in Dongguan, China. Recto-vaginal swabs were collected from pregnant women at gestational age 35-37 weeks between January 1st 2009 and December 31st 2014. Isolates were serotyped by latex-agglutination and were tested against seven antimicrobials by disk diffusion. Of 7,726 pregnant women who completed GBS testing, 636 (8.2%) were GBS carriers...
2017: PloS One
https://www.readbyqxmd.com/read/28810827/validation-of-%C3%AE-lactam-minimum-inhibitory-concentration-predictions-for-pneumococcal-isolates-with-newly-encountered-penicillin-binding-protein-pbp-sequences
#14
Yuan Li, Benjamin J Metcalf, Sopio Chochua, Zhongya Li, Robert E Gertz, Hollis Walker, Paulina A Hawkins, Theresa Tran, Lesley McGee, Bernard W Beall
BACKGROUND: Genomic sequence-based deduction of antibiotic minimum inhibitory concentration (MIC) has great potential to enhance the speed and sensitivity of antimicrobial susceptibility testing. We previously developed a penicillin-binding protein (PBP) typing system and two methods (Random Forest (RF) and Mode MIC (MM)) that accurately predicted β-lactam MICs for pneumococcal isolates carrying a characterized PBP sequence type (phenotypic β-lactam MICs known for at least one isolate of this PBP type)...
August 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28810248/antibiotic-susceptibility-and-molecular-characterization-of-escherichia-coli-o157-isolates-from-urinary-tract-infections
#15
Zonglan Xie, Ziqiang Dong, Ping Zhu, Lusheng Zhang, Xiaobo Chen, Chuanjiang Dong
BACKGROUND: Escherichia coli O157 is an important food-borne pathogen that can cause diarrhoea, hemorrhagic colitis, and hemolytic uraemic syndrome. Enterobacterial repetitive intergenic consensus sequence PCR (ERIC-PCR) and multilocus sequence typing (MLST) are good methods for molecular typing and the extensive use of antibiotics is a contributing factor to the increasing incidence of antimicrobial-resistant for these strains. OBJECTIVES: The aim of this study was to determine the prevalence, antimicrobial resistance, and genetic diversity of E...
August 16, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28809447/pulmonary-delivery-of-tea-tree-oil-%C3%AE-cyclodextrin-inclusion-complexes-for-the-treatment-of-fungal-and-bacterial-pneumonia
#16
Miao Li, Lifei Zhu, Tongtong Zhang, Boming Liu, Lina Du, Yiguang Jin
OBJECTIVES: Bacterial pneumonia is a common cause of death worldwide. Tea tree oil (TTO) is a potent antimicrobial natural product, which is formulated in dry powder inhalers (DPIs) for the treatment of fungal and bacterial pneumonia. METHODS: Tea tree oil-β-cyclodextrin inclusion complexes (TTO-β-CD) were prepared and characterized. Aerodynamic properties of TTO-β-CD powders were measured. The rat models of fungal (Candida albicans) and bacterial (Acinetobacter baumannii) pneumonia were prepared...
August 15, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28808592/a-case-of-fulminant-meningococcemia-it-is-all-in-the-complement
#17
Kellie L Hawkins, Mariah Hoffman, Sonia Okuyama, Sarah E Rowan
Eculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Complement deficiency is a well-known risk factor for meningococcal infection. We describe a case of a young patient with PNH treated with eculizumab who presented with a life-threatening case of nongroupable meningococcemia. As this new biologic agent becomes more widely prescribed, providers should be aware of the increased risk of meningococcemia. In addition to vaccination, providers may consider the use of oral penicillin for antibiotic prophylaxis against Neisseria meningitidis in these cases of functional complement deficiency...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28808302/effects-of-one-week-empirical-antibiotic-therapy-on-the-early-development-of-gut-microbiota-and-metabolites-in-preterm-infants
#18
Danping Zhu, Sa Xiao, Jialin Yu, Qing Ai, Yu He, Chen Cheng, Yunhui Zhang, Yun Pan
The early postnatal period is the most dynamic and vulnerable stage in the assembly of intestinal microbiota. Antibiotics are commonly prescribed to newborn preterm babies and are frequently used for a prolonged duration in China. We hypothesized that the prolonged antibiotic therapy would affect the early development of intestinal microbiota and their metabolites. To test this hypothesis, we analyzed the stool microbiota and metabolites in 36 preterm babies with or without antibiotic treatment. These babies were divided into three groups, including two groups treated with the combination of penicillin and moxalactam or piperacillin-tazobactam for 7 days, and the other group was free of antibiotics...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808076/influence-of-the-duration-of-penicillin-prescriptions-on-outcomes-for-acute-sore-throat-in-adults-the-descarte-prospective-cohort-study-in-uk-general-practice
#19
Michael Moore, Beth Stuart, Fd Richard Hobbs, Chris C Butler, Alastair D Hay, John Campbell, Brendan C Delaney, Sue Broomfield, Paula Barratt, Kerenza Hood, Hazel Everitt, Mark Mullee, Ian Williamson, David Mant, Paul Little
BACKGROUND: Guidelines recommend 10-day treatment courses for acute sore throat, but shorter courses may be used in practice. AIM: To determine whether antibiotic duration predicts adverse outcome of acute sore throat in adults in routine care. DESIGN AND SETTING: A secondary analysis of the DESCARTE (Decision rule for the Symptoms and Complications of Acute Red Throat in Everyday practice) prospective cohort study of 12 829 adults presenting in UK general practice with acute sore throat...
August 14, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28807923/pbp4-mediates-%C3%AE-lactam-resistance-by-altered-function
#20
Som S Chatterjee, Liang Chen, Aubre Gilbert, Thaina M da Costa, Vinod Nair, Sandip K Datta, Barry N Kreiswirth, Henry F Chambers
Penicillin Binding Protein 4 (PBP4) can provide high-level β-lactam resistance in S. aureus A series of missense and promoter mutations associated with pbp4 were detected in strains that displayed high-level resistance. We hereby show that the missense mutations facilitate the β-lactam resistance mediated by PBP4 and the promoter mutations lead to the overexpression of pbp4 Our results also suggest a co-operative interplay between PBPs for β-lactam resistance.
August 14, 2017: Antimicrobial Agents and Chemotherapy
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